|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MFSD14 |
cd17387 |
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ... |
117-527 |
0e+00 |
|
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340945 [Multi-domain] Cd Length: 410 Bit Score: 754.26 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 117 VYHAVVVIFLEFFAWGLLTTPMLKVLHETFPQHTFLMNGLIQGVKGFLSFMSAPLIGALSDVWGRKSFLLVTVFFTCVPI 196
Cdd:cd17387 1 VYHAVVVIFLEFFAWGLLTTPMITVLHETFPQHTFLMNGLVQGVKGILSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 197 PLMRISPWWYFAMISVSGVFSVTFSVIFAYVADITQEHERSTAYGLVSATFAASLVTSPAIGAYLSASKGDNLVVLVATV 276
Cdd:cd17387 81 PLMRISPWWYFAMISVSGIFSVTFSVIFAYVADITTEEERSTAYGLVSATFAASLVTSPALGAYLSESYGDNLVVLVATI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 277 VAVLDICFILLAVPESLPEKMRPASWGAPISWEQADPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQIIG 356
Cdd:cd17387 161 VALLDICFILLAVPESLPEKMRPASWGAPISWEQADPFASLRKVGKDKTVLLICITVFLSYLPEAGQYSSFFVYLKQVMG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 357 FGPATIAAFIAVVGILSIIAQTVFLSILMRSIGNKNTVLLGLGFQMLQLTWYGFGSQPWMMWAAGAVAAMSSITFPAISA 436
Cdd:cd17387 241 FEYEEVAAFIAVVGILSITAQTLLLSILMRSIGAKNTILLGLGFQMLQLAWYGFGSQHWMMWAAGAVAAMSSITFPAISA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 437 LVSRNAEPDQQGVVQGIITGIRGLCNGLGPALYGFIFFLFHVELNELAPVQSSDKNtMQDPSDEKAIIPGPPFLFGACAV 516
Cdd:cd17387 321 LVSRYADPDQQGAVQGMITGIRGLCNGLGPALFGFVFYLFHVDLNEIKPVQSSKQR-MQNPSLEGAIIPGPPFLFGAISV 399
|
410
....*....|.
gi 2052141748 517 LLAFLVALFIP 527
Cdd:cd17387 400 LLAILVASFIP 410
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
122-525 |
7.45e-66 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 218.22 E-value: 7.45e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 122 VVIFLEFFAWGLLTTPMLKVLHET-FPQHTFLMNGLIQGVKGFLSFMSAPLIGALSDVWGRKSFLLVTVFFTCVPIPLMR 200
Cdd:cd17330 3 LVVFLDALGFGIVFPVLPFYVREFnKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 201 ISP--WWYFAMISVSGVFSVTFSVIFAYVADITQEHERSTAYGLVSATFAASLVTSPAIGAYLSASKGDNLVVLVATVVA 278
Cdd:cd17330 83 LSRnlWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 279 VLDICFILLAVPeslpekmrpaswgapisweqadpfaslkkvgkdsTVLLICITVFLSYLPEAGQYSSFFLYLRQIIGFG 358
Cdd:cd17330 163 LLNLVLVLFFLP----------------------------------PLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFS 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 359 PATIAAFIAVVGILSIIAQTVFLSILMRSIGNKNTVLLGLGFQMLQLTWYGFGS-QPWMMWAAGAVAAMSSITFPAISAL 437
Cdd:cd17330 209 PSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASsVPLLVLAAAILAFGTGIVFPALSAL 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 438 VSRNAEPDQQGVVQGIITGIRGLCNGLGPALYGFIFFLFhvelnelapvqssdkntmqdpsdekaiIPGPPFLFGACAVL 517
Cdd:cd17330 289 LSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFL---------------------------GPGVPFLLAAGLLL 341
|
....*...
gi 2052141748 518 LAFLVALF 525
Cdd:cd17330 342 IALFLLSL 349
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
154-525 |
2.63e-39 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 147.78 E-value: 2.63e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 154 NGLIQGVKGFLSFMSAPLIGALSDVWGRKSFLLVTVFFTCVPIPLMRISP--WWYFAMISVSGVFSVTFSVIFAYVADIT 231
Cdd:cd17388 40 YGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPtlWWLYLGRIIAGITGATGAVAAAYIADVT 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 232 QEHERSTAYGLVSATFAASLVTSPAIGAYLsASKGDNLVVLVATVVAVLDICFILLAVPESLPEKMRPASwgapiSWEQA 311
Cdd:cd17388 120 PPEQRARNFGLLGAAFGLGFIAGPALGGLL-GEISPRAPFLVAAGLNGLNFLLGLFVLPESLPPERRRAF-----RWRRA 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 312 DPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQIIGFGPATIAAFIAVVGILSIIAQTVFLSILMRSIGNK 391
Cdd:cd17388 194 NPFGSLRWLTGFPGLLGLLAVFFLIQLIGQVPATTWVLFTEDRFDWSPTMVGLSLAVFGLLHALFQAFVTGPIAKRLGEK 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 392 NTVLLGLGFQMLQLTWYGFGSQPWMMWAAGAVAAMSSITFPAISALVSRNAEPDQQGVVQGIITGIRGLCNGLGPALYGF 471
Cdd:cd17388 274 RAILLGLAADALGFLLLAFATQGWMVFPILILLALGGIAGPALQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTG 353
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 2052141748 472 IFFLFhvelnelapvqssdkntmqdpsdeKAIIPGPPFLFGACAVLLAFLVALF 525
Cdd:cd17388 354 IFAAS------------------------PATWPGLAWIIGAALYLICLVLAYR 383
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
152-526 |
1.98e-27 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 113.83 E-value: 1.98e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 152 LMNGLIQGVKGFLSFMSAPLIGALSDVWGRKSFLLVTVFFTCVPIPLMRI--SPWWYFAMISVSGVFS-VTFSVIFAYVA 228
Cdd:cd17325 31 AQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFatSYWQLLLARFLQGLASaAVWPAAMALIA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 229 DITQEHERSTAYGLVSATFAASLVTSPAIGAYLSASKGDNLVVLVATVVAVLDICFILLAVPESLPEKmrpaswgAPISW 308
Cdd:cd17325 111 DIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPP-------NKRAV 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 309 EQADPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQIIGFGPATIAAFIAVVGILSIIAQtVFLSILMRSI 388
Cdd:cd17325 184 SAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQ-PPAGKLSDRI 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 389 GNKNTVLLGLGFQMLQLTWYGFGSQPWMMWAAGAVA-AMSSITFPAISALVSRNAEPDQQGVVQGIITGIRGLCNGLGPA 467
Cdd:cd17325 263 GRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLgLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPL 342
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 2052141748 468 LYGFIFFLFHvelnelapvqssdkntmqdpsdekaiiPGPPFLFGACAVLLAFLVALFI 526
Cdd:cd17325 343 LGGFLYDAFG---------------------------FATPFLAAAALLLLAAVLFLLL 374
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
120-464 |
2.78e-26 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 110.06 E-value: 2.78e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 120 AVVVIFLEFFAWGLLTTPMLKVLHetfpqHTFLMNGLIQGVKGFLSFMSAPLIGALSDVWGRKSFLLVTVFFTCVPIPLM 199
Cdd:COG2814 18 GAFLSGLGIGIVLPALPLIAADLG-----ASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLC 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 200 RISP--WWYFAMISVSGVFS-VTFSVIFAYVADITQEHERSTAYGLVSATFAASLVTSPAIGAYLSASKGDNLVVLVATV 276
Cdd:COG2814 93 ALAPslWLLLAARFLQGLGAgALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAV 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 277 VAVLDICFILLAVPESLPEKMRPASwgapisweqadpfASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQIIG 356
Cdd:COG2814 173 LALLALLLLLRLLPESRPAARARLR-------------GSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 357 FGPATIAAFIAVVGILSIIAQTVFlSILMRSIGNKNTVLLGLGFQMLQLTWYGFGSQPWMMWAAGAVAAMS-SITFPAIS 435
Cdd:COG2814 240 LSASAAGLLLALFGLGGVLGALLA-GRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGfGLLFPLLQ 318
|
330 340
....*....|....*....|....*....
gi 2052141748 436 ALVSRNAEPDQQGVVQGIITGIRGLCNGL 464
Cdd:COG2814 319 ALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
120-473 |
1.18e-24 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 105.97 E-value: 1.18e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 120 AVVVIFLEFFAWGLLTTPMLKVLHETfpQHTFLMNGLIQGVKGFLSFMSAPLIGALSDVWGRKSFLLVTVFFTCVPIPLM 199
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSF--GLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 200 RISPWWYFAMIS---VSGVFSVTFSVIFAYVADITQEHERSTAYGLVSATFAASLVTSPAIGAYLSASKGDNLVVLVATV 276
Cdd:cd06174 79 AFAPSFWLLLLGrflLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 277 VAVLDICFILLA-VPESLPEKMRPaswgAPISWEQADPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQII 355
Cdd:cd06174 159 AALALLAAILLLlVVPDPPESARA----KNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 356 GFGPATIAAFIAVVGILSIIAQTVFLSILMRSIGNKNTVLLGLGFQMLQLTWYGFGSQPWMMWAAGA-VAAMSSITFPAI 434
Cdd:cd06174 235 GLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLlLGFGLGGLLPLS 314
|
330 340 350
....*....|....*....|....*....|....*....
gi 2052141748 435 SALVSRNAEPDQQGVVQGIITGIRGLCNGLGPALYGFIF 473
Cdd:cd06174 315 FALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLL 353
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
155-476 |
6.90e-23 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 100.76 E-value: 6.90e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 155 GLIQGVKGFLSFMSAPLIGALSDVWGRKSFLLVTVFFTCVPIPLMRI--SPWWYFAMISVSGVF-SVTFSVIFAYVADIT 231
Cdd:cd17329 38 GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFahSPWLFAIALVLTGFGgGLFEPASEAMIADVT 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 232 QEHERSTAYGLVSATFAASLVTSPAIGAYLSaskGDNLVVLVATVVAVLDICFILLA--VPESLPEKMRPaswgapiswE 309
Cdd:cd17329 118 TPENRTRAFSLLYWAINLGVAIGPLLGGLLL---LYSFRLLFLAAAVLFLLAALVLLflLPETRPKRRAA---------E 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 310 QADPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQIIGFGPATIAAFIAVVGILSIIAQtVFLSILMRSIG 389
Cdd:cd17329 186 KTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQ-FPVARLVERFR 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 390 NKNTVLLGLGFQMLQLTWYGFGSQPWMMWAAGAVAAM-SSITFPAISALVSRNAEPDQQGVVQGIITGIRGLCNGLGPAL 468
Cdd:cd17329 265 LRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLgEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLV 344
|
....*...
gi 2052141748 469 YGFIFFLF 476
Cdd:cd17329 345 GGLLLDLL 352
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
122-466 |
1.78e-22 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 99.03 E-value: 1.78e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 122 VVIFLEFFAWGLLTTPMLKVLHETFpQHTFLMNGLIQGVKGFLSFMSAPLIGALSDVWGRKSFLLVTVFFTCVP--IPLM 199
Cdd:pfam07690 3 LAAFLAALGRSLLGPALPLLLAEDL-GISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGllLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 200 RISPWWYFAMISVSGVF-SVTFSVIFAYVADITQEHERSTAYGLVSATFAASLVTSPAIGAYLSASKGDNLVVLVATVVA 278
Cdd:pfam07690 82 ASSLWLLLVLRVLQGLGaGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 279 VldICFILLAVPESLPEKMRPASWGApiswEQADPFASLKKVGKDstVLLICITVFLSYLPEAGQYSSFFLYLRQIIGFG 358
Cdd:pfam07690 162 L--LAAVLLLLPRPPPESKRPKPAEE----ARLSLIVAWKALLRD--PVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 359 PATIAAFIAVVGILSIIAQtVFLSILMRSIGNKNTVLLGLGFQML---QLTWYGFGSQPWMMWAAGAVAAMS-SITFPAI 434
Cdd:pfam07690 234 ALLAGLLLGLGGLLGAIGR-LLLGRLSDRLGRRRRLLLALLLLILaalGLLLLSLTLSSLWLLLALLLLGFGfGLVFPAL 312
|
330 340 350
....*....|....*....|....*....|..
gi 2052141748 435 SALVSRNAEPDQQGVVQGIITGIRGLCNGLGP 466
Cdd:pfam07690 313 NALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
155-532 |
8.11e-20 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 92.27 E-value: 8.11e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 155 GLIQGVKGFLSFMSAPLIGALSD----VWG-RKSFLLVTVFFTCVPIPLMRISP--------WWYFAMISVSGVFSVTFS 221
Cdd:COG2211 49 GLILLVARLWDAITDPLIGALSDrtrtRWGrRRPWILIGAIPLALSFVLLFTAPdlsptgklIYALVTYLLLGLAYTLVN 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 222 VIF-AYVADITQE-HERSTAYGLVSATFAASLVTSPAIGAYLSASKGDNLVVLVATVVAVLDICFILLA------VPESL 293
Cdd:COG2211 129 IPYsALGAELTPDyEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFlltffgTKERP 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 294 PEKMRPASWgapisweqadpFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQIIGFGPATIAAFIAVVGILS 373
Cdd:COG2211 209 VPEEEKVSL-----------KESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAA 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 374 IIAqTVFLSILMRSIGNKNTVLLGLGFQMLQLTWYGF--GSQPWMMWAAGAVAAM-SSITFPAISALVSRNAEPDQQ--- 447
Cdd:COG2211 278 LLG-APLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFlgPGNLWLLLVLAALAGIgLGAILVLPWAMLADVVDYDEWktg 356
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 448 ----GVVQGIITGIRGLCNGLGPALYGFIFFLFHVelnelapvqssDKNTMQDPSDEKAIIPGpPFLFGACAVLLAFLVA 523
Cdd:COG2211 357 rrreGLYFGIFTFAIKLGQALAGALAGLLLALFGY-----------VAGAAQSPSALTGIRLL-FFLLPAVLLLLAALLL 424
|
....*....
gi 2052141748 524 LFIPEHSKT 532
Cdd:COG2211 425 LFYPLTRER 433
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
114-472 |
1.62e-18 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 87.60 E-value: 1.62e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 114 RPSVYHAVVVIFLEFFAWGLLTT---PMLKVLHETFpQHTFLMNGLIQGVKGFLSFMSAPLIGALSDVWGRKSFLLVTVF 190
Cdd:COG0738 3 KKNYRRALIAIYLLFFLWGFATAlwgPLIPALKDAF-GLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 191 FTCVPIPLMRISPWWYFAMIS--VSGV-FSVTFSVIFAYVADITQEHeRSTAYGLVSATFAASLVTSPAIGAYLSASKGD 267
Cdd:COG0738 82 LMALGLLLFALAPSYPLLLLAlfLLGLgLGLLDVAANPYVAALGPET-AASRLNLLHAFFSLGALLGPLLGGLLILLGLS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 268 NLVVLVATVVAVLDICFILLAVPESLPEKMRPASwgapiswEQADPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSF 347
Cdd:COG0738 161 LSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEE-------EAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 348 FLYLRQIIGFGPATIAAFIAVVGILSIIAQTVFlSILMRSIGNKNTVLLGLGFQMLQLTWYGFGSQPWM-MWAAGAVAAM 426
Cdd:COG0738 234 PLYLKDVLGLSEATAALGLSLFWGGMTIGRFLG-GFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLaLIGLALVGLG 312
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 2052141748 427 SSITFPAISALVSRNAEPDQQGVVqGIITGIRGLCNGLGPALYGFI 472
Cdd:COG0738 313 LSLMFPTIFSLALDGLGKRTAAAV-SAVLIMGIVGGAIGPPLIGFL 357
|
|
| MFS_SLC46 |
cd17386 |
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ... |
123-522 |
1.86e-16 |
|
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340944 [Multi-domain] Cd Length: 360 Bit Score: 81.17 E-value: 1.86e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 123 VIFLEFFAWGLLTTPMLkvlHETFPQHTFLMNGLIQGVKGFLSfmsAPLIGALSDVWGRKSFLLVTVF--------FTCV 194
Cdd:cd17386 7 IVFLYMFASVLSGPVTQ---NFVYAANFYLYMNLMGSIPPLFS---SLFLGSWSDRYGRKPPLLMSLVglllssliLVLI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 195 PIPLMRISPWWYF---AMISVSGVFSVTFSVIFAYVADITQEHERSTAYGLVSATFAASLVTSPAIGAYLSASKGDNLVV 271
Cdd:cd17386 81 VYFTTVPSVWWFYlsaIPLALFGGFTAFLSASFAYISDISSEKKRTYRMAILEVALGLGGFLGSLLSGHLFKALGYAWSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 272 LVATVVAVLDICFILLAVpeslpekmrpaswgapisweqadpfaslkkvgkdSTVLLICITVFLSYLPEAGQYSSFFLYL 351
Cdd:cd17386 161 SISAALLLIALLYILFFL----------------------------------TLLILLLLAAFLTIFVLSGESDVLYLFV 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 352 RQIIGFGPATIAAFIAvVGILSIIAQTVFLSILMRSIGNKNTV---LLGLGFQMLQLTWYGFGSQPWMMWAAGAVAAMSS 428
Cdd:cd17386 207 LEKFAWNVKDFSYFST-LGSLIYLTGMLGGVLLLRCLLKMSDStlaMLGLASHILSSLLFAFATNTWMMYLAAVVGMFNG 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 429 ITFPAISALVSRNAEPDQQGVVQGIItgirGLCNGLGPALYGFIFflfhvelNELApvqssdKNTMqdpsdekAIIPGPP 508
Cdd:cd17386 286 IVGPMIRSILSKLVPKSEQGKIFSLL----SVLESLSPLVASPIY-------NNIY------KATL-------TTFPGFF 341
|
410
....*....|....
gi 2052141748 509 FLFGACAVLLAFLV 522
Cdd:cd17386 342 FLLSAGLLLIPVIL 355
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
155-478 |
3.17e-16 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 80.74 E-value: 3.17e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 155 GLIQGVKGFLSFMSAPLIGALSDVWGRKSFLLVT-------VFFTCVPIPLMRISPWWYFAMISVSGVFSVTFSVIF-AY 226
Cdd:cd06173 37 GLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILAdllrallAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARqAL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 227 VADITQEHERSTAYGLVSATFAASLVTSPAIGAYLSASKGDNLVVLVATvvavldICFILLAVPESLPEKMRPASWGAPI 306
Cdd:cd06173 117 LPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINA------LSFLLSALLLLFIRRPPPAAPGESS 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 307 SWEQADPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQIIGFGPATIAAFIAVVGILSIIAqTVFLSILMR 386
Cdd:cd06173 191 SLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLG-ALLLGRLSK 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 387 SIGNKNTVLLGLGFQMLQLTWYGFGSQPWMMWAAGAVAAMSSITF-PAISALVSRNAEPDQQGVVQGIITGIRGLCNGLG 465
Cdd:cd06173 270 RRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFnVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLG 349
|
330
....*....|...
gi 2052141748 466 PALYGFIFFLFHV 478
Cdd:cd06173 350 ALLAGLLADALGL 362
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
122-472 |
4.25e-16 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 79.96 E-value: 4.25e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 122 VVIFLEFFAWGLLTtPMLkvlhetfPQH------TFLMNGLIQGVKGFLSFMSAPLIGALSDVWGRKSFLLVTVFFTCVP 195
Cdd:cd17390 3 LVGFLDLFGVSMIL-PLL-------STHirslgaSPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 196 IPLMRISPWWYFAMIS--VSGVFSVTFSVIFAYVADITQEHERSTAYGLVSATFAASLVTSPAIGAYLSASKGdnlvvLV 273
Cdd:cd17390 75 YVLLGFSTSLALLFLSriPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDG-----GF 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 274 ATVVAVLDICFILLAVPESLpekMRPASWGapisweqadpFASLKkvgkdstvLLICITVFLSylpeagqYSSFFLYLRQ 353
Cdd:cd17390 150 YYVALLCSAIFILNAGLVWF---LLSKLWD----------LLLVR--------FLMGFSVLLF-------RSNFSLYLEE 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 354 IIGFGPATIAAFIAVVGILSIIAQTVFLSILMRSIGNKNTVLLGLGFQM-LQLTWYGFGSQPWMMWAAGA-VAAMSSITF 431
Cdd:cd17390 202 RFDLSPKTIGYLISYSGVLGALSGFLVGRILKLYKNNEYLLLLHSFILLaLSLLGLALAPSIWLLVLCLTpLSISSAVLR 281
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 2052141748 432 PAISALVSRNAEPDQQGVVQGIITGIRGLCNGLGPALYGFI 472
Cdd:cd17390 282 TCSTSLLLSRGKSKERGTLLGVGQSVTSLARILAPLLSGLL 322
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
153-473 |
4.39e-16 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 80.34 E-value: 4.39e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 153 MNGLIQGVKGFLSFMSAPLIGALSDVWG-RKSFLLVTVFFTCVPIPLMRI-SPWWYFamIS-VSGVFSVTFSVIFAYVAD 229
Cdd:cd17331 36 VFGYLQTTFSVLQLVGGPLFGRFGDLFGpRAALVLSFLSSALSYLLLAFAsSVPMLF--LSrLPSVFMHAMQAAQMVVTD 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 230 ITQEHERSTAYGLVSATFAASLVTSPAIGAYLSASKGDNLVVLVATVVAVLDICfILLAVPESLPEKMRPASWGAPISWE 309
Cdd:cd17331 114 LTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIV-LVILLIPSNTKSKREKEAKESASPP 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 310 QADPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQIIGFGPATIAAFIAVVGILSIIAQTVFLSILMRSIG 389
Cdd:cd17331 193 SVFNLKEILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMSYAGVLGMVVQGLLVGPLTKRFG 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 390 NKNTVLLGLGFQMLQLTWYGF-GSQPWMMWAAGAVAAMSSITFPAISALVSRNAEPDQQGVVQGIITGIRGLCNGLGPAL 468
Cdd:cd17331 273 ERSLLKLSVALLAIGYLLLAFvTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTI 352
|
....*
gi 2052141748 469 YGFIF 473
Cdd:cd17331 353 GGALL 357
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
168-473 |
2.16e-15 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 77.97 E-value: 2.16e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 168 SAPLIGALSDVWGRKSFLLVTVFFTCVPIPLMRISPWWYFAMIS--VSGVF-SVTFSVIFAYVADITQEHERSTAYGLVS 244
Cdd:cd17324 50 GALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLAraLAGLAhGGFWAIAAAYAADLVPPEKRGRAIGLVF 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 245 ATFAASLVTSPAIGAYLSASKGDNLVVLVATVVAVLDICFILLAVPESLPEKMRPASwgapisweqadPFASLKKVGKDS 324
Cdd:cd17324 130 SGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLG-----------LLSSLLLLLRNP 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 325 TVLLICITVFLSYLPEAGQYSSFFLYLRQIIGFGPATIAAFIAVVGILSIIAqTVFLSILMRSIGNKNTVLLGLGFQMLQ 404
Cdd:cd17324 199 RLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVG-SPLAGRLADRGGRRALLIALLLLAAAL 277
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 405 LTWYGFGSQPWMMWAAGAV-AAMSSITFPAISALVSRNAePDQQGVVQGIITGIRGLCNGLGPALYGFIF 473
Cdd:cd17324 278 LLLTLLGPSPLLLLVGLVLwGLGFFAAHSALQTRVLRLA-PEARGLASSLYLAAYNLGGALGAALGGLVL 346
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
152-476 |
4.04e-15 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 77.31 E-value: 4.04e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 152 LMNGLIQGVKGFLSFMSAPLIGALSDVWGRKSFLLVTVFFTCVPiplmrispwwyFAMISVSGVFSVTF----------- 220
Cdd:cd17389 64 LFGGLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAIS-----------YALWAVSRSFTIFLlsrivggiskg 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 221 --SVIFAYVADITQEHERSTAYGLVSATFAASLVTSPAIGAYLSASKGDNLVVLVAT------VVAVLDICFILLAVPES 292
Cdd:cd17389 133 nvSLSTAIVADVTSPKKRSKGMALIGVAFSLGFIIGPMIGAYFASFTRSLGEVFFSMpalfalVLALADLLFIFFFLPET 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 293 LPEKMRPASWGapisweqadpfaslkkvgkdstvllicitVFLSYLPEAG-QYSSFFLyLRQIIGFGPATIAAFIAVVGI 371
Cdd:cd17389 213 LPSNLRRLGLV-----------------------------YFLYLFLFSGlEFTLTFL-THQRFQYTSMQQGKMFFFIGI 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 372 LSIIAQTVFLSILmRSIGNKNTVLLGLGFQMLQLTWYGFGSQPWMMWAAGAVAAM-SSITFPAISALVSRNAEPDQQGVV 450
Cdd:cd17389 263 IMALVQGGYVRRI-KPGKEKKAVLQGLILLIPAFLLIGWASSVTVLYAGLFLYSFaAATVVPCLTTLVSGYGSDDQKGTV 341
|
330 340
....*....|....*....|....*.
gi 2052141748 451 QGIITGIRGLCNGLGPALYGFIFFLF 476
Cdd:cd17389 342 MGIFRSLGALARALGPIVACTVYWLA 367
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
155-472 |
4.96e-12 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 67.61 E-value: 4.96e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 155 GLIQGVKGFLSFMSAPLIGALSDVWG-RKSFLLVTVFFTCV---PIPLMRISPWWYFAMISVSGVF-SVTFSVIFAYVAD 229
Cdd:cd17335 35 GILIGIRPFVRFLSAPLWGALADRFGkRKALLLLSLLAAVLfflSLFFVAQIFWLLLLLVILGAFFsAPVVPLVDSITLQ 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 230 ITQEHERStaYGLV----SATFAAslvTSPAIGAYLSASKGDNLVVLVATVVAVLDICFILLAVPESLPEKMRpaswgap 305
Cdd:cd17335 115 YLGEERER--YGKQrlwgSIGFGI---AALLVGILIDRSSTYKNYTIAFYVFAVLMLLALLLALKFPFRPKHP------- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 306 iswEQADPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQiIGfGPATIAAFIAVVGILSIIAQTVFLSILM 385
Cdd:cd17335 183 ---EPNENTGGLLALLRNPRVLAFLLVAFLMGFGHGLIYSFLFWHLQD-LG-GSKTLIGLLWTVGVVSEIPFFFFSSRLI 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 386 RSIGNKNTVLLGLGFQMLQLTWYGFGSQPWMMwaaGAVAAMSSITF----PAISALVSRNAEPDQQGVVQGIITgirGLC 461
Cdd:cd17335 258 QRFGHVGLLYLGLLAYVVRWLLYSFLENPWLV---LPIELLHGLTFalvwAAAVSYASAAAPPGLRATAQGLLQ---GLY 331
|
330
....*....|.
gi 2052141748 462 NGLGPALYGFI 472
Cdd:cd17335 332 FGLGGGLGSLI 342
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
120-473 |
5.77e-12 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 67.60 E-value: 5.77e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 120 AVVVIFLEFFAWGLLTTPMLKVLHETFPQhtflmNGLIQGVKGFLSFMSAPLIGALSDVWGRKSFLLVTVFFTCVPIPLM 199
Cdd:COG2223 13 AFFLAFGVWYLWSVLAPPLAEEFGLSAAQ-----LGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 200 --RISPWWYFAMISVSGVFS-VTFSVIFAYVADITQEHERSTAYGLVSATFAASLVTSPAIGAYLSASKGDNLVVLVATv 276
Cdd:COG2223 88 alAVSYWLLLLLGLLLGIGGgGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILG- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 277 vavldICFILLAVPESLPEKMRPASWGAPisweQADPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQIIG 356
Cdd:COG2223 167 -----ILLLVVAVLAWLFLRDPPAGAAAA----AKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 357 FGPATIAAFIAVVGILSIIAqTVFLSILMRSIGNKNTVLLGLGFQMLQLTW--YGFGSQPWMMWAAGAVAAMSSITFPAI 434
Cdd:COG2223 238 LSAATAGLLAALFALLGALG-RPLGGWLSDRIGGRRVLLIVFALMALGLLLlaLALGSLWLFLVLFLLLGLALGGGNGAV 316
|
330 340 350
....*....|....*....|....*....|....*....
gi 2052141748 435 SALVSRNAEPDQQGVVQGIITGIRGLCNGLGPALYGFIF 473
Cdd:COG2223 317 FALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALL 355
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
120-527 |
8.95e-12 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 66.82 E-value: 8.95e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 120 AVVVIFLEFFAWGLLTTPMLKVLHETFPQHtflmnGLIQGVKGFLSFMSAPLIGALSDVWGRKSFLLVTVFFTCVPIPLM 199
Cdd:COG2271 18 AYFLNYLDRSNLSVAAPPLQADLGLSAAQL-----GLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 200 RI--SPWWYFAMISVSGVF-SVTFSVIFAYVADITQEHERSTAYGLVSATFAASLVTSPAIGAYLSASKGdnlvvlvatv 276
Cdd:COG2271 93 GFatSFWQLLLLRFLLGLGeAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFG---------- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 277 vavLDICFILLAVPeslpekmrPASWGAPisweqadpfaslkkvgkdsTVLLICITVFLSYLPEAGQYSSFFLYLRQIIG 356
Cdd:COG2271 163 ---WRAAFLILGLP--------GLLLALL-------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRG 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 357 FGPATIAAFIAVVGILSIIAqTVFLSILMRSIG--NKNTVLLGLGFQMLQLTWYGFGSQPWMMWAAGAVAAMSSI-TFPA 433
Cdd:COG2271 213 LSLAQAGLLLSLPFLAGIVG-SLLGGWLSDRLGrrRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGgAFGL 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 434 ISALVSRNAEPDQQGVVQGIITGIRGLCNGLGPALYGFIFFLFHvelnelapvqssdkntmqdpsdekaiiPGPPFLFGA 513
Cdd:COG2271 292 LWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG---------------------------YQAAFLLLA 344
|
410
....*....|....
gi 2052141748 514 CAVLLAFLVALFIP 527
Cdd:COG2271 345 ALALLAALLALLLL 358
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
121-525 |
2.30e-11 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 65.69 E-value: 2.30e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 121 VVVIFLEFFAWGLLTtPMLKVLHETFPQHTFLMnGLIQGVKGFLSFMSAPLIGALSDVWGRKSFLLVTVFFTCVPIPLMR 200
Cdd:cd17489 2 LLANFFFFLSFYLLL-PVLPLYAHDLGGSEAVA-GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 201 I--SPWWYFAMISVSGV-FSVTFSVIFAYVADITQEHERSTAYGLVSATFAASLVTSPAIGAYLSASKGDNLVVLVATVv 277
Cdd:cd17489 80 LatSVALLLVLRLIHGIgWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAV- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 278 avldICFILLAVPESLPEKMRPASwgapiswEQADPFASLKKVGKDSTVLLICITVFLSYLPEAGqYSSFF-LYLRQIig 356
Cdd:cd17489 159 ----LALLALLLVFLVKDPPPVAA-------EEAEAGTRAFRRLVEKKVLPPALILFLASIAYGA-ISTFLpLYAAER-- 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 357 fGPATIAAFIAVVGILSIIAQTVFLSILMRsIGNKNTVLLGLGFQMLQLTWYGFGSQPWMMWAAGAVAAMS-SITFPAIS 435
Cdd:cd17489 225 -GISNAGLFFTVYAIALLLSRPFSGKLSDR-KGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGfGLLFPALQ 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 436 ALVSRNAEPDQQGVVQGIITGIRGLCNGLGPALYGFIFFLFHvelnelapvqssdkntmqdpsdekaiiPGPPFLFGACA 515
Cdd:cd17489 303 ALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFG---------------------------YRAMFLLAAVV 355
|
410
....*....|
gi 2052141748 516 VLLAFLVALF 525
Cdd:cd17489 356 VLLALVLYIF 365
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
160-477 |
4.08e-11 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 64.98 E-value: 4.08e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 160 VKGFLSFMSAPLIGALSDVWGRKSFLLVTVFFTCVPIPLMRISPW---WYFAMISVSGVFSVTFS-VIFAYVADITQEHE 235
Cdd:cd17355 46 VGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSlwqLYLLWGLLGGGGAGTLAaVAFATVAAWWFERR 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 236 RSTAYGLVSATFA-ASLVTSPAIGAYLSASKGDNLVVLVATVVAVLDICFILLAVPESLPEKMRPASWGAPisweqADPF 314
Cdd:cd17355 126 RGLALGILTAGGGlGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDASP-----ASPG 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 315 ASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQIiGFGPATIAAFIAVVGILSIIAqTVFLSILMRSIGNKNTV 394
Cdd:cd17355 201 STLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADR-GISPAAAAVALALIGLFNIVG-RLLSGWLGDRYSPRRLL 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 395 LLGLGFQMLQLTWYGFG-SQPWMMWAAGAVAAMSSI-TFPAISALVSRNAEPDQQGVVQGIITGIRGLCNGLGPALYGFI 472
Cdd:cd17355 279 AASYALRALGLALLLLLpFPPLALLLFAALFGLGWGaTVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLL 358
|
....*
gi 2052141748 473 FFLFH 477
Cdd:cd17355 359 YDRTG 363
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
168-527 |
1.41e-10 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 62.98 E-value: 1.41e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 168 SAPLIGALSDVWGRKSFLLVTVFFTCVPIPLMRISPWWYFAMIS--VSGVFSVTFSVIFAYVADITQEHERSTAYGLVSA 245
Cdd:cd17504 47 STPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGraLQGIGGAVFPLAFALVREEFPPERVPVAQGILSA 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 246 TFAASLVTSPAIGAYLSASKGDNLVVLVATVvavldICFILLAVPESLPEKM--RPASWGAPIsweqadpfaslkkvgkd 323
Cdd:cd17504 127 TFGIGAGIGLPLGGWIVQHLGWRWIFWTAAP-----VAVLLAALVPLIDLRLlrRRNVLLANI----------------- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 324 sTVLLICITVFLSYlpeagQYSSFFLYLRQIIGFG-PATIAAFIAVVGILSIIAQTVFLSILMRSIGNKNTVLLGLGFQM 402
Cdd:cd17504 185 -TALLAGFGMFMVF-----QLLPQLLQLPTPTGFGlGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISA 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 403 LQLTWYGF-GSQPWMMWAAGAVAAM-SSITFPAISALVSRNAEPDQQGVVQGIITGIRGLCNGLGPALYGFIFflfhvel 480
Cdd:cd17504 259 VGLLLLALlHSSLWALVVALLLIGIgLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAIL------- 331
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 2052141748 481 nelapvqssdknTMQDPSDEKAIIPGPP-----FLFGACAVLLAFLVALFIP 527
Cdd:cd17504 332 ------------TTYTVSITSGGVPTEGayvlaFLIGAALALAALLLSLLIP 371
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
132-455 |
2.82e-10 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 62.21 E-value: 2.82e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 132 GLLTTPMLKVLHETFPQHTFLMNGLIQGVKGFLSFMSAPLIGALSDVWGRKSFLLVTVFFTCV--PIPLMRISPWWYFAM 209
Cdd:cd17473 15 GAAIAPALPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIggVAGLFLDSLYALLAS 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 210 -----ISVSGVFSVTFSVIfayvADITQEHERSTAYGLVSATFAASLVTSPAIGAYLsASKGDNLVVLVATVVAvldicF 284
Cdd:cd17473 95 rallgIGVAGIMTLATALI----GDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGAL-AEIGWRAPFLVYLLAL-----P 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 285 ILLAVPESLPEKMRPASwgapiswEQADPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQIIGFGPATIAA 364
Cdd:cd17473 165 VLILVLLFLPEPARKSK-------SAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 365 FIAVVGILSIIAQTVFlSILMRSIGNKNTVLLGLGFQMLQLTWYGFGSQPWMMWAAGAVAAM-SSITFPAISALVSRNAE 443
Cdd:cd17473 238 ALAIASLAGAIGALLF-GRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLgFGLLLPTLNSWAMSLVP 316
|
330
....*....|..
gi 2052141748 444 PDQQGVVQGIIT 455
Cdd:cd17473 317 PELRGRAMGIVT 328
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
114-264 |
1.58e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 59.90 E-value: 1.58e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 114 RPSVYHAVVVIFLEFFAWGLLTtPMLKVLHETFPQHTFLMNGLIQGVKGFLSFMSAPLIGALSDVWGRKSFLLVTVFFTC 193
Cdd:cd17325 198 DRRLLALFLAIFVLAFAFGALE-PFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSA 276
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2052141748 194 VPIPLMRISP--WWYFAMISVSGV-FSVTFSVIFAYVADITQEHERSTAYGLVSATFAASLVTSPAIGAYLSAS 264
Cdd:cd17325 277 VALLLLPLATsfWLLLLLLALLGLgLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDA 350
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
170-527 |
1.05e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 57.18 E-value: 1.05e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 170 PLIGALSDVWGRKSFLLVTVFFTCVPIPLMRISP--WWYFAMISVSGVF-SVTFSVIFAYVADITQEHERSTAYGLVSAT 246
Cdd:cd17321 49 LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPslAFLIAARALQGIGaAAIMPASLALIAATFPGERRGRALGLWGAV 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 247 FAASLVTSPAIGAylsaskgdnlvvlvatvvavldicfILLAVpeslpekmrpASWGApISWEQAdPFASLKKVGKdSTV 326
Cdd:cd17321 129 VGIGAALGPLLGG-------------------------LLLEL----------FGWRW-IFLINV-PIGLVALLLA-RTF 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 327 LLICITVFLSYLPEAGQYSSFFLYLRQIIGFGPATIAAFIAVVGILSIIAqTVFLSILMRSIGNKNTVLLGLGFQMLQLT 406
Cdd:cd17321 171 SGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVA-APLAGRLADRFGPRLVLVAGLLLTAVGLL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 407 WYGFGSQPWMMWAAGAVAAMSSI----TFPAISALVSRNAEPDQQGVVQGIITGIRGLCNGLGPALYGFIFFLFHVELNE 482
Cdd:cd17321 250 LLALLGADSSVWLLLPGLVLLGLglglFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAGLSANLG 329
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 2052141748 483 LAPVQSSDKNTMQDPSDekaiIPGPPFLFGACAVLLAFLVALFIP 527
Cdd:cd17321 330 DSGVAALLSAAAAAFAA----GFHLAFLVAAALALLAALLALLLP 370
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
155-476 |
1.09e-08 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 57.25 E-value: 1.09e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 155 GLIQGVKGFLSFMSAPLIGALSDVWGRKSFLLV------TVFFTCVPIPLMRISPWWYFAMISVSGVFSVTFSVIFAyVA 228
Cdd:pfam12832 37 GLITAILPLTRILAPPIWGWLADRTGKRKAVVRlasilaAVLFLSVLFIPISLTFWWLALLVVLFSFFWNAILPQFE-VA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 229 DITQEHERSTAYGLV----SATFAaslVTSPAIGAYLsaskgdNLVVLVATVVAVLDICFILLAVPESLPEKMRPASWGA 304
Cdd:pfam12832 116 TLQHLGEKRKDYGRQrlwgSVGFA---LSVFGLGALF------DHYSVGLLPSVLFYLFAALMLLSLLLPLAPPEMEYES 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 305 PISweqadPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQiIGFGPATIAAFIAvVGILSIIAQTVFLSIL 384
Cdd:pfam12832 187 KGG-----SKAVFWNLLKQPEVIIFFLAAFLLGFSHGPFYTFLFLYLEN-LGASNTLLGALWA-LGVVAEIPLFFYAHRL 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 385 MRSIGNKNTVLLGLGFQMLQLTWYGFG-SQPWMMWAAGAVAAMS-SITFPAISALVSRNAEPDQQGVVQGIITGIR-GLC 461
Cdd:pfam12832 260 LRRFGHRNLLIIALLLTALRWLLYAFFvENPWLVLPIQFLHAISfGLTHAAAIEYVRRIFPGSLQGTGQALYSGLYfGLG 339
|
330
....*....|....*
gi 2052141748 462 NGLGPALYGFIFFLF 476
Cdd:pfam12832 340 GALGSLIGGQLWDLF 354
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
169-476 |
1.63e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 56.81 E-value: 1.63e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 169 APLIGALSDVWGRKSFLLVTVFFTCVP--IPLMRISPWWYFAMISVSGVFSVTFSVI-FAYVADITQEHERSTAYGLVSA 245
Cdd:cd17474 51 MPVAGVLADRFGRKKVLLPGLLLFGIGglLCGLSDSFALLLAGRALQGIGAAGLGPLaLTLIGDLFEGGERAKAMGLYEA 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 246 TFAASLVTSPAIGAYLSASKGDNLVVLVATVVAVLDICFILLAVPESLPEKMRPASwgapiswEQADPFASLKKVGKDST 325
Cdd:cd17474 131 ALGLGIAVGPLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEPKEKAKSSSAT-------KLRDLKKALRGRGLLTF 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 326 VLLICIT-----VFLSYLPeagqyssffLYLRQIIGFGPATIAAFIAVVGILSIIAQTVFLSILMRSIGNKNTVLLGLGF 400
Cdd:cd17474 204 LVSAFLYfflyfAFLTYLP---------FLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLL 274
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2052141748 401 QMLQLTWYGFGSQPWMMWAAGAVAAMSS-ITFPAISALVSRNAEPDQQGVVQGIITGIRGLCNGLGPALYGFIFFLF 476
Cdd:cd17474 275 YALSLLLLGFVPSLALLLIAIVLFGLGLgLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIF 351
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
163-474 |
5.21e-08 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 55.27 E-value: 5.21e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 163 FLSFMSAPLI-GALSDVWGRKSFLLVTVFFTCVP--IPLMRISPWWYFAMISVSGVFSVTFSVI-FAYVADITQEHERST 238
Cdd:cd17320 44 LLGFALGQLLyGPLSDRFGRRPVLLAGLLLFILAslLCALASSIEQLLIARFLQGLGAAAGSVVaRAIVRDLYSGAELAK 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 239 AYGLVSATFAASLVTSPAIGAYLSASKGDNLVVLVATVVAVLDICFILLAVPESLPEKMRPASWGApisweqadPFASLK 318
Cdd:cd17320 124 IFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETLPEEKRKPLLSS--------LLRAYK 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 319 KVGKDSTVLL------ICITVFLSYLPEAGqyssfFLYLrQIIGFGPATIAAFIAVVGILSIIAqTVFLSILMRSIGNKN 392
Cdd:cd17320 196 RVLKNRRFLGyalalgLSFAGLFAYLAAAP-----FIYI-EQLGLSPAQFGLLFALNAIALILG-SLLNGRLVRRFGPRR 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 393 TVLLGLGFQ------MLQLTWYGFGSQPWMMWAAGAVAAMSSITFPAISALVSRnAEPDQQGVVQGIITGIRGLCNGLGP 466
Cdd:cd17320 269 LLRLGLLLLlaaalvLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALE-PFPHVAGTASALLGFLQFLIGALAG 347
|
....*...
gi 2052141748 467 ALYGFIFF 474
Cdd:cd17320 348 ALVGLLPN 355
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
329-476 |
5.80e-08 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 54.73 E-value: 5.80e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 329 ICITVFLSYLPEAGQYSSFFLYLRQIIGFGPATIAAFIAVVGILSIIAQtVFLSILMRSIGNKNTVLLGLGFQMLQLTWY 408
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQ-PLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2052141748 409 GFGSQPWMMWAAGAVAAM-SSITFPAISALVSRNAEPDQQGVVQGIITGIRGLCNGLGPALYGFIFFLF 476
Cdd:pfam07690 80 LFASSLWLLLVLRVLQGLgAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF 148
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
134-473 |
1.75e-07 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 53.37 E-value: 1.75e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 134 LTTPMLKVLHETFPQHTFLMNGLIQGVKGFL-SFMSAPLiGALSDVWGRKSFLLV--TVFFTCVPIPLMRISPWWYFAMI 210
Cdd:cd17472 14 LVLPVLSVYAKSLPGATPTLIGLALGIYGLTqAIFQIPF-GLLSDRIGRKPVILFglLLFIAGSLLAAYATSIYGLILGR 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 211 SVSGVFSVTfSVIFAYVADITQEHERSTAYGLVSA----TFAASLVTSPAIGAYLSASKgdnlVVLVATVVAVLDICFIL 286
Cdd:cd17472 93 ALQGSGAIS-SVVMALLADLTREENRTKAMALIGAsigiAFAISMVLGPLLAAHLGVSG----LFLITAILSLVSLLILL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 287 LAVPESLPEKMRPASWGapisweqadpfASLKKVGKDSTVLLICITVFLSYLpeagQYSSFF----LYLRQIIG------ 356
Cdd:cd17472 168 FFVPDPPKIVQISEKEK-----------KKLKKLLKNKRLLRLDFSIFILHF----VLMAFFyilpLLLTQLGGgkgqlw 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 357 --FGPATIAAFIAVVgILSIIA-------QTVFLSILMRSIGnkntvLLGLGFQMLQLTWYGFGSQPWMMwaagAVAAMS 427
Cdd:cd17472 233 kvYLPAILIGFILMV-PFVIYAekkgkmkQVFVSSILLIAVG-----FLLLLFAATSLWLLIIGLIIFFI----GFNLLE 302
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 2052141748 428 SItfpaISALVSRNAEPDQQGVVQGIITGIRGLCNGLGPALYGFIF 473
Cdd:cd17472 303 AL----LPSLVSKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLW 344
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
155-477 |
2.22e-07 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 53.23 E-value: 2.22e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 155 GLIQGVKGFLSFMSAPLIGALSDVWG-RKSFLLVTVFFTCVPIPLM---RISPWWYFAMISVSGVFSVTFSVIF--AYVA 228
Cdd:COG2270 55 GYALAIAGLLVALLAPVLGAIADRSGrKKPFLAFFTLLGVLATAALffvAPGGLWLGLLLFVLANIGFEGSLVFynAFLP 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 229 DITQEHER----STAY------GLVSATFAASLVTSPAIGAYLSASKGDNlvvlvatvvavldICFILLA---------- 288
Cdd:COG2270 135 DIATPEEIgrvsGLGWalgylgGVLLLLINLALFLKPEAFGLPDAGEAVR-------------ISFLLTAlwwllfalpl 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 289 ---VPESLPEKMRPASWGAPISWEQAdpFASLKKVGKDSTVL--LICITVFLSYLpeAGQYSSFFLYLRQIIGFGPATIA 363
Cdd:COG2270 202 flfLPERPRPGPAPPRGAVRAGFREL--RRTLRELRRYRDLLrfLLAYFFYRDGV--QTVIAFAGIYAAGVLGFSTTELI 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 364 AFIAVVGILSIIAqTVFLSILMRSIGNKNTVLLGLGFQMLQLTWYGFGSQPWMMWAAGAVAAMSSITFPAIS-ALVSRNA 442
Cdd:COG2270 278 VFGLLVQIVAALG-ALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVMGGIQALSrSLLARLI 356
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 2052141748 443 EPDQQGVVQGI------ITGIrglcngLGPALYGFIFFLFH 477
Cdd:COG2270 357 PPGREAEFFGLyalsgkAASF------LGPLLFGLVTQLTG 391
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
105-247 |
4.87e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 51.90 E-value: 4.87e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 105 GGSAQQGIGRPSVYHAVVVIFLEFFAWGLLTTPMLKVLHETFpQHTFLMNGLIQGVKGFLSFMSAPLIGALSDVWGRKSF 184
Cdd:COG2814 197 RGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVL-GLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRL 275
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2052141748 185 LLVTVFFTCVPIPLMRI--SPWWYFAMISVSGV-FSVTFSVIFAYVADITQEHERSTAYGLVSATF 247
Cdd:COG2814 276 LLIGLLLLALGLLLLALagSLWLLLLALFLLGFgFGLLFPLLQALVAELAPPEARGRASGLYNSAF 341
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
325-472 |
1.45e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 50.36 E-value: 1.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 325 TVLLICITVFLSYLpEAGQYSSFFLYLRQIIGFGPATIAAFIAVVGILSIIAQtVFLSILMRSIGNKNTVLLGLGFQMLQ 404
Cdd:COG2814 11 ALLALALGAFLSGL-GIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGA-PLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2052141748 405 LTWYGFGSQPWMMWAAGAVAAM-SSITFPAISALVSRNAEPDQQGVVQGIITGIRGLCNGLGPALYGFI 472
Cdd:COG2814 89 SLLCALAPSLWLLLAARFLQGLgAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLL 157
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
122-266 |
1.58e-06 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 50.65 E-value: 1.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 122 VVIFLEFFAWGLLTTPMLKVLHETFPQHTFLMNGLIqgvkGFLSFMSAPLIGALSDVWGRKSFLLVT---VFFTCVPIPL 198
Cdd:COG2223 215 FGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALF----ALLGALGRPLGGWLSDRIGGRRVLLIVfalMALGLLLLAL 290
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2052141748 199 MRISPWWYFAMISVSGVF-SVTFSVIFAYVADITQEHERSTAYGLVSATFAASLVTSPAIGAYLSASKG 266
Cdd:COG2223 291 ALGSLWLFLVLFLLLGLAlGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATG 359
|
|
| MFS_MFSD6L |
cd17479 |
Major facilitator superfamily domain-containing protein 6-like and similar transporters of the ... |
316-473 |
3.47e-06 |
|
Major facilitator superfamily domain-containing protein 6-like and similar transporters of the Major Facilitator Superfamily; Major facilitator superfamily domain-containing protein 6-like (MFSD6L) protein family includes a group uncharacterized proteins similar to human major facilitator superfamily domain-containing protein 6 (MFSD6). MFSD6 is also called Macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. The MFSD6L family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341032 [Multi-domain] Cd Length: 376 Bit Score: 49.23 E-value: 3.47e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 316 SLKKVGKDSTVLLICITVFLSYLPeAGQYSSFFLYLRQIIGFGPATIAAFIAVvGILSIIAQTVFLSILMRSIGNKNTVL 395
Cdd:cd17479 195 GLRLLGGDGRAILYALTVFLVGFV-GSTVQNFLFWLMQDKGGSELHMGLSIAL-ALLSEILMSFFGNWLLRKLGHAGCVV 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 396 LGLGFQMLQLTWYGFGSQPWMMWAAGAVAAMSSITF-PAISALVSRNAEPDQQGVVQGIITGI-RGLCNGLGPALYGFIF 473
Cdd:cd17479 273 LGLLGLGAQLLYYSFLWTPWAVLPIELLHAFSNGALwWAVNSQVEFLASPGMERSLQLVLRALyYGIGFALGSFVSGFIY 352
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
136-472 |
4.12e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 49.09 E-value: 4.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 136 TPMLKVLHETFpQHTFLMNGLIQGVKGFLSFMSAPLIGALSDVWGRKSFLLVTVFFTCVPIPLMRISP--WWYFAMISVS 213
Cdd:cd17478 16 PALLPLLIAKL-GLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPnyWLLLLLVALA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 214 GVFSVTFSVIFAYVADITQEHERSTAYGLVSA--TFAASLvtSPAIGAYLSASKGDNLVVLVATVVAvldICFILLAVPE 291
Cdd:cd17478 95 GIGSAAFHPEGARLASQAAGGRRGLAMSIFSVggNLGFAL--GPLIAAALVALFGGLGLLILLIIPG---LAVALLLLRL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 292 SLPEKMRPASWGAPISWeqadpfaSLKKVGKDSTVLLICITVFLSYLPEAGqYSSFF-LYLRQiIGFGPATIAAFIAVVG 370
Cdd:cd17478 170 RPLKKPEAKKAAAKSSA-------RSTLKGVWRALLLLLIIVFLRSWVLSS-LTTFLpFYLVQ-RGYSLVFAGLLLSLFL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 371 ILSIIAqTVFLSILMRSIGNKNTVLLGLGFQMLQLTWYGFGSQPWMMWAAGAVAAMSSITFPAISALVSRNAePDQQGVV 450
Cdd:cd17478 241 FAGAIG-TLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELL-PGNVGLA 318
|
330 340
....*....|....*....|..
gi 2052141748 451 QGIITGIRGLCNGLGPALYGFI 472
Cdd:cd17478 319 SGLMMGLSFGLGGIGAPVLGAL 340
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
152-475 |
4.39e-06 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 49.23 E-value: 4.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 152 LMNGLIQGVKGFLSFMSAPLIGALSDVWGRKSFLLVTVFFTCVPIPlmrispwwYFAMISVSGVFSVTFSVIFAYVadit 231
Cdd:pfam13347 72 LLSAIILAVSFILLFTPPELGRAPLFIWLLATYILLRIAYTFFEIP--------YWSLGPELTRDYDERTSLTSYR---- 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 232 qehERSTAYGLVSATFAASLVTSPaIGAYLSASKGDNLVVLVATVVAVLDICFILLAVPESLPEKMRPASWGApiswEQA 311
Cdd:pfam13347 140 ---SFFSVGGGLLAAALAFPLVLI-LGGTGLERKGYRIFALIGAVLMLLGVIITAAGTKERVSMRSKEDTGQK----EAG 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 312 DPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQIIGFGPAtIAAFIAVVGILSIIAqTVFLSILMRSIGNK 391
Cdd:pfam13347 212 SLLDMLKEVFRNRAFLILLASFLLAALAMGVLNGLLLYYFRYVLGNGFA-ASAFPLVFTIGALLG-IPLWPPLAKRIGKK 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 392 NTVLLGLGFQM--LQLTWYGFGSQPWMMWAAGAVA----AMSSITFPAISALVSRNAEPDQQGVVQGIITGIRGLCNGLG 465
Cdd:pfam13347 290 NTYILGALITIagFALALLLGPNNTLLFLVLYIIIgfgyGSSFFLPWSMLADVVDYGELRTGKRREGTFFAMWSFISKLA 369
|
330
....*....|
gi 2052141748 466 PALYGFIFFL 475
Cdd:pfam13347 370 TGVGLGVSGL 379
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
116-266 |
1.60e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 47.17 E-value: 1.60e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 116 SVYHAVVVIFLEFFAWGLLTTPMLKVLHETFpQHTFLMNGLIQGVKGFLSFMSAPLIGALSDVWGRKSFLLVTVFFTCVP 195
Cdd:COG2271 181 RFWLLALAYFLVYFALYGFLTWLPTYLVEVR-GLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAA 259
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2052141748 196 IPLMRI----SPWWYFAMISVSGVFS-VTFSVIFAYVADITQEHERSTAYGLVSATFAASLVTSPAIGAYLSASKG 266
Cdd:COG2271 260 LALLLLallpSPALAIALLFLAGFGLgGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG 335
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
168-261 |
1.84e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 47.15 E-value: 1.84e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 168 SAPLIGALSDVWGRKS-FLLVTVFFTCVPIPLM-RISPWWYFAMISVSGVF-SVTFSVIFAYVADITQEHERSTAYGLVS 244
Cdd:cd17370 250 AAYPAGRLSDRIGRKKlLILGYLSLALAYLGFAlGSSLWLLLLGFILWGLYmGAQESIERAAVADLVPAELRGTAYGLFN 329
|
90
....*....|....*..
gi 2052141748 245 ATFAASLVTSPAIGAYL 261
Cdd:cd17370 330 TVVGIGWLLASLIAGYL 346
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
155-479 |
2.15e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 46.77 E-value: 2.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 155 GLIQGVKGFLSFMSAPLIGALSDVWG-RKSFLLVTVFFTCVPIPLMRISPWWYFAMISVS------GVFSvtfSVIFAYV 227
Cdd:cd17370 37 GLIEGLAEALGSLLRLFSGYLSDRTGkRKPLVILGYGLSALAKPLLALAGSWQLVLLLRIlerlgkGIRT---PPRDALL 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 228 ADITQEHERSTAYGLVSA--TFAAslVTSPAIGAYLSASKGDNLVVLVATVVAVLDI-CFILLAVPESLPEKMRPaswga 304
Cdd:cd17370 114 ADATPPSGRGKAFGLHRAldTLGA--VLGPLLAALLLYLLGGNYRTIFLLAAIPALLaLLILLFVVKEYPRPPKL----- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 305 piswEQADPFASLKKVGKDstVLLICITVFLSylpEAGQYS-SFFLYLRQIIGFGPATIAAFIAVVGILSIIAQTVFlSI 383
Cdd:cd17370 187 ----RKKSKKTSLKKLPKA--FWLYLLAVALF---ALGNFSfAFLILRAQELGLSAALIPLLYALFNLVYALAAYPA-GR 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 384 LMRSIGNKNTVLLGLGFQMLQLTWYGFGSQPWMMWAAGAVAAMS-SITFPAISALVSRNAEPDQQGVVQGIITGIRGLCN 462
Cdd:cd17370 257 LSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYmGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGW 336
|
330
....*....|....*..
gi 2052141748 463 GLGPALYGFIFFLFHVE 479
Cdd:cd17370 337 LLASLIAGYLWDLISPS 353
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
120-266 |
2.89e-05 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 46.34 E-value: 2.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 120 AVVVIFLEFFAWGLLTTPMLKVLHETFPQHTFLMNGliqgvkGFLSFMS-APLIGALSDVWGRKSFLLVTVFFTCVPIPL 198
Cdd:COG0477 22 GTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSA------YLLGRAIgLLLFGRLGDRYGRKRVLLIGLLLFGLASLL 95
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2052141748 199 MRISP--WWYFAMISVSGVF-SVTFSVIFAYVADITQEHERSTAYGLVSATFAASLVTSPAIGAYLSASKG 266
Cdd:COG0477 96 CGLAPspELLIAARALQGIGaGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALG 166
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
170-527 |
6.82e-05 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 45.29 E-value: 6.82e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 170 PLIGALSDV----WGRKS---------FLLVTVFFTCVPIPLMRISPWWYFAMISVSGVFSVTFSVIF-AYVADITQE-H 234
Cdd:cd17332 53 PLMGYLIDRtrsrWGRFRpwllwgaipLALLFVLLFTTPDGSGTGKLIYALITYILLDLLYTLVNIPYtALIPELTDDpE 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 235 ERS--TAYGLVSATFAASLVTSPAIGAYLSASKGDNLVVLVATVVAVLDICFILLAvpeslpekmrpasWGAPISWEQAD 312
Cdd:cd17332 133 ERTslTSWRMFFATIGGLLVTVLPPPLVAYFGGGNASRGYFLTALIIGIIGIILLL-------------ICFFGTRERVV 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 313 PFASLKKVGKDSTV----------LLICITVFLSYLPEAGQYSSFFLYLRQIIGFGPATIAAFIAVVGILSIIaqTVFLS 382
Cdd:cd17332 200 PPEEEKSKLPLLKSlkallknrpfLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLA--LLPWP 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 383 ILMRSIGNKNTVLLGLGFQMLQLTWYGFGSQP--WMMWAAGAVAAM-SSITFPAISALVSRNAEPDQ--QGV-VQGIITG 456
Cdd:cd17332 278 PLKKRFGKKKAFFIGLLLAILGLLLLFFLPPGnlVLILVLAVLAGIgYGGANLLPWAMLADVIDYGElkTGKrREGIFYS 357
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2052141748 457 IRGLCNGLGPALYGFIFFLFHVELNELAPVQSsdkntmQDPSDEKAIIpgppFLFG---ACAVLLAFLVALFIP 527
Cdd:cd17332 358 VMTFFRKLGLALAGALVGLILSLAGYVANAAA------QSASALNGIR----LLIAvlpAVLLLLALILMSFYP 421
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
326-473 |
7.90e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 45.25 E-value: 7.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 326 VLLICITVFLSYLPEAGqYSSFFLYLRQIIGFGPATIAAFIAVVGILSIIAQtVFLSILMRSIGNKNTVLLGLGFQMLQL 405
Cdd:COG2271 12 LALLFLAYFLNYLDRSN-LSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQ-IPAGLLADRFGRRRVLAIGLLLWGLAT 89
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2052141748 406 TWYGFGSQPWMMWAA-GAVAAMSSITFPAISALVSRNAEPDQQGVVQGIITGIRGLCNGLGPALYGFIF 473
Cdd:COG2271 90 LLFGFATSFWQLLLLrFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLL 158
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
125-425 |
2.10e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 43.74 E-value: 2.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 125 FLEFFAWGLLTTPMLKVLHETFPQHTFLMNGLIQGVkGFLS-FMSAPLIGALSDVWGRKSFLLVTVFFTCVPIPLMRISP 203
Cdd:cd17316 9 FFDAYDFFLIGFVAPVLAAEFSLGLSLLQTGLLFAA-GFLGrPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLP 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 204 --WWYFAMISVSGVF-SVTFSVIFAYVADITQEHERSTAYGLVSATFAASLVTSPAIGAYLSASKGDNLVVLvatvvavl 280
Cdd:cd17316 88 tpILLLVLRFLQGIGiGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWGWR-------- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 281 dICFILLAVPESLPEKMRPASWGAPISWeqadpfaslkkvgkdsTVLLICITVFLSYLPEagqyssfflYLRQIIGFGPA 360
Cdd:cd17316 160 -ILFLIGALPALLALLLRRRTLLLILLW----------------FFISFGYYGLTTFLPT---------YLQTVLGLSPA 213
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2052141748 361 TIAAFIAVVGILSIIAQTVFLsILMRSIGNKNTVLLG--LGFQMLQLTWYGFGSQPWMMWAAGAVAA 425
Cdd:cd17316 214 TSSLYLLLISLGALVGALIAG-LLSDRIGRKKTLVIGliLSGILALPLFYLLSGSPTLLLLLLFILS 279
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
155-472 |
2.47e-04 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 43.41 E-value: 2.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 155 GLIQGVKGFLSFMSAPLIGALSDVWGRKSFLLVTVFFTCVPIPLMRISP--WWYFAMISVSGVFSVTFSVIFAYVADITQ 232
Cdd:cd17391 39 GLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTnvWQLLILRLLQGVFSGYVPNATALIASQTP 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 233 EHERSTAYGLVSATFAASLVTSPAIGAYLSASKGDNLVVLVATVVAVldICFILLAVpeSLPEKMRPASWGAPISWEQAd 312
Cdd:cd17391 119 KEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLF--LAFLLTLF--FVKEDFKPVEKKKMVSTKEV- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 313 pfasLKKVGKDSTVLLICITVFLSylpeagQYSSFF------LYLRQIIGFGP--ATIAAFI-AVVGILSIIAqTVFLSI 383
Cdd:cd17391 194 ----WNSVPNPSLLISLFVTTFII------QLANQSiepiltLYIRQLMGDASnlAFISGLVfSATGVSSLLS-APRLGK 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 384 LMRSIGNKNTVLLGLGFQMLQLTWYGFGSQPW-MMWAAGAVAAMSSITFPAISALVSRNAEPDQQGVVQGIITGIRGLCN 462
Cdd:cd17391 263 LGDRIGHHRILLGALLASALLYIPQAFVQTPWqLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGN 342
|
330
....*....|
gi 2052141748 463 GLGPALYGFI 472
Cdd:cd17391 343 VAGPLLGSAI 352
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
347-545 |
2.97e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 43.37 E-value: 2.97e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 347 FFLYLRQIIGFgPATIAAFIAVVGILSIIAQTVFLSILMRSIGNKNTVLLGLGFQMLQLTWYGFGSQPWMMWAAGA-VAA 425
Cdd:cd17329 22 MAIYLHQQLGL-SASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVlTGF 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 426 MSSITFPAISALVSRNAEPDQQGVVQGIITGIRGLCNGLGPALYGFIFflfhvelnelapvqssdkntmqdpsdekAIIP 505
Cdd:cd17329 101 GGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLL----------------------------LYSF 152
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 2052141748 506 GPPFLFGACAVLLAFLVALFIPEHSKTSCTRKHSISSAQS 545
Cdd:cd17329 153 RLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRG 192
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
123-266 |
5.24e-04 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 42.60 E-value: 5.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 123 VIFLEFF---AWGLLTTPMLKVLHETFPQHTFLMNGLIQGVKGFLSFMSAPLIGALSDVWGRK---SFLLVTVFFTCVPI 196
Cdd:cd17353 217 LLWLMFFlnaTAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKntlSIAFLIQGVAMFLL 296
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2052141748 197 PLMRISPWWYFAMISVSGV-FSVTFSVIFAYVADITQEHERSTAYGLVSATFAASLVTSPAIGAYLSASKG 266
Cdd:cd17353 297 PFIGSVAVLFVLGVALIGFcYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGG 367
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
325-528 |
5.26e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 42.56 E-value: 5.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 325 TVLLICITVFLSYLPEAGqYSSFFLYLRQIIGFGPATIAAFIAVVGILSIIAQtVFLSILMRSIGNKNTVLLGLGFQMLQ 404
Cdd:COG2223 6 VLLLATLAFFLAFGVWYL-WSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLR-IPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 405 LTWYGFGSQPWMMWAAGAVAAMSS-ITFPAISALVSRNAEPDQQGVVQGIITGIRGLCNGLGPALYGFIFFLFHVElnel 483
Cdd:COG2223 84 LLLLALAVSYWLLLLLGLLLGIGGgGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWR---- 159
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 2052141748 484 apvqssdkntmqdpsdekaiipGPPFLFGACAVLLAFLVALFIPE 528
Cdd:COG2223 160 ----------------------NAFLILGILLLVVAVLAWLFLRD 182
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
121-268 |
8.09e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 42.03 E-value: 8.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 121 VVVIFLEFFAWGLLTTPMLKVLHETFPQHTFLMnGLIQGVKGFLSFMSAPLIGALSD-VWGRKSFLLVTVF---FTCVPI 196
Cdd:cd06174 209 LLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVA-GLLLSLFGLAGALGSLLLGLLSDrLIGRKPLLLIGLLlmaLGLALL 287
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2052141748 197 PLMRISPWWYFAMISVSGVFSVTFSVIFAYVADITQEHERSTAYGLVSATFAASLVTSPAIGAYLSASKGDN 268
Cdd:cd06174 288 LLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGL 359
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
153-472 |
1.09e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 41.44 E-value: 1.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 153 MNGLIQGVKGFLSFMSAPLIGALSDVWG-RKSFLLVTVFFTCVPIPLMRI--SPWWYFAMISVSGVFSVTFSVIFAYVAD 229
Cdd:cd17490 32 MIGIILGAYGISQMLLRIPLGILSDRIGkRKLFIIIGLLFTVLASLIMILfpSPWGLLIARFLSGIAAATWVSFTVLYAS 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 230 ITQEHERSTAYGLVSATFAASLVTSPAIGAYLSASKGDNLVVLVATVVAVldICFIL-LAVPESLPEKMRpaswgapisw 308
Cdd:cd17490 112 YFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGV--LGFILsLFIKEERREKKP---------- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 309 eQADPFASLKKVGKDSTVLLICITVFLS-YLPEAGQYSSFFLYLRQiIGFGPATIAAFIAVVGILSIIAQTVFLSILMRS 387
Cdd:cd17490 180 -VLTELKELLSVLKDKKLLFFSLLAILQqMITFSTTFGFTPLIAKQ-LGASSFQLGLLSIIYLLPNALASLLSGTLFYKK 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 388 IGNKNTVLLGLGFQMLQLTWYGFGSQPWMMWAAGAVAAMSS-ITFPAISALVSRNAEPDQQGVVQGIITGIRGLCNGLGP 466
Cdd:cd17490 258 LGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTgILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGP 337
|
....*.
gi 2052141748 467 ALYGFI 472
Cdd:cd17490 338 VLVGII 343
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
120-267 |
1.20e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 41.36 E-value: 1.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 120 AVVVIFLEFFAWGLLTTPML----KVLHetFPQHTFLMNGLIQGVKGFLSFmsaPLIGALSDVWGRKSFLLVTVFFTCV- 194
Cdd:cd17369 233 AIGLRLAENVLFYLFTTFALsyatQTLG--VDRSTVLLAVLIASVVAAITI---PLFGWLSDRVGRRPVYLAGALLAALf 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 195 --PIPLM---RISPWWYFAMISVSGVF-SVTFSVIFAYVADITQEHERSTAYGL---VSATFAASLVtsPAIGAYLSASK 265
Cdd:cd17369 308 afPFFWLldtGSTWLIVLAAVVVLGVLhGMMYGPQAAFLAELFPTRVRYTGASLgyqLGAILGGGFA--PLIATALVAAT 385
|
..
gi 2052141748 266 GD 267
Cdd:cd17369 386 GS 387
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
322-527 |
1.42e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 41.02 E-value: 1.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 322 KDSTVLLICITVFLSYLpeaGQYSSFF---LYLRQIIGFGPATIAAFIAVVGILSIIAQtVFLSILMRSIGNKNTVLLGL 398
Cdd:cd17503 176 KDRNFTLGLLLSFLLGL---GLFGAMFllpLYLQNVLGYSAFESGLVLAPGGLASAILS-PLVGRLLDKFGPRLLLLAGL 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 399 ---GFQMLQLTWYGFGSQPWMMWAAGAVAAMS-SITFPAISALVSRNAEPDQQGVVQGIITGIRGLCNGLGPALYGFIF- 473
Cdd:cd17503 252 lllALGTLLLAFLTPDTSLWLIILPLFIRGLGmGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLt 331
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 2052141748 474 ---FLFHVELNELAPVQSSDKNTMQDPSDEkaiipgppFLFGACAVLLAFLVALFIP 527
Cdd:cd17503 332 nrtQFHHSRLSELLAQQVQKQALIIAFNDA--------FLVSAILLLVGLLLALFLR 380
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
120-266 |
1.47e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 41.05 E-value: 1.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 120 AVVVIFLEFFAWGLLTTPMLKVLHETF---PQHTFLMNGLIqgvkGFLSFMSAPLIGALSDVWGRKSFLLVTVFFTCVPI 196
Cdd:cd17316 182 LILLWFFISFGYYGLTTFLPTYLQTVLglsPATSSLYLLLI----SLGALVGALIAGLLSDRIGRKKTLVIGLILSGILA 257
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2052141748 197 PLM----RISPWWYFAMISVSGVFSVTFSVIF-AYVADITQEHERSTAYGLVSAT-FAASLVTSPAIGAYLSASKG 266
Cdd:cd17316 258 LPLfyllSGSPTLLLLLLFILSFFVGGVWGALyAYLAELFPTEVRATGVGLSYNLgRLGGGGAPPLIALLLASTGG 333
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
170-261 |
2.62e-03 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 40.36 E-value: 2.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 170 PLIGALSDVWGRKSFLLVT-VFFTCVPIPLMRI-----SPWWYFAMISVSGVFSVTFSVIFAYV-ADITQEHERST---- 238
Cdd:cd17367 277 PLGGRLSDRIGRRPLLLFFgIGGTLATVPLLSAldhtdSPYTAFALVLVGLVFLSGYTSINAVVkAELFPTHVRALgvgl 356
|
90 100
....*....|....*....|...
gi 2052141748 239 AYGLVSATFAAslvTSPAIGAYL 261
Cdd:cd17367 357 PYALAVAIFGG---TAPYVALWL 376
|
|
| MFS_MFSD8 |
cd17326 |
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ... |
155-262 |
3.04e-03 |
|
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340884 [Multi-domain] Cd Length: 374 Bit Score: 40.27 E-value: 3.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 155 GLIQGVKGFLSFMSAPLIGALSDVWGRKSFLLVTVFFTCVPIPLM-----RISPWWYFAMIS---VSGVFSVTFSVIFAY 226
Cdd:cd17326 39 GWVVAAYSLGQLVFSPVFGYWSNKTSSVKEPLIVSILIAIVGNILyalaeYFPSNRKYVMLVarfLIGVGAGNVAVLRAY 118
|
90 100 110
....*....|....*....|....*....|....*.
gi 2052141748 227 VADITQEHERSTAYGLVSATFAASLVTSPAIGAYLS 262
Cdd:cd17326 119 VAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFT 154
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
152-476 |
3.17e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 39.85 E-value: 3.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 152 LMNGLIQGVKGFLSFMSAPLIGALSDVWG-RKSFLLVTVFFTCVPIPLM-RISPWWYFAMISVSGV-FSVTFSVIFAYVA 228
Cdd:cd17477 31 ALIGLVASAYYLGILLGSPLVPRLIRRVGhIRAFAAGAAITAVSVLLLAlTDSPWVWFLLRFVMGIgLAGLFVVSESWLN 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 229 DITQEHERSTAYGLVSATFAASLVTSPAIGAYLSaskgdnlvVLVATVVAVLDICFILLAVPESLpekmrpaSWGAPISW 308
Cdd:cd17477 111 ALATNENRGRVLGLYSTVLGLGFALGPLLLALVG--------TAGALPFLIAAVLLLLALVPLLL-------TRRAAPEI 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 309 EQADPFASLKKVgkdSTVLLICITVFLSYLPEAGQYSSFFLYLRQiIGFGPATIAAFIAVVGILSIIAQtVFLSILMRSI 388
Cdd:cd17477 176 EEAESISLRRLL---RIAPLALLGAFVAGFLEGAFYSLLPLYGLR-LGLSVAQAALLLAAFVLGGLLLQ-WPLGWLADRF 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 389 GnKNTVLLGLGF--QMLQLTWYGFGSQPWMMWAAGAVAAMSSIT-FPAISALVSRNAEPDQQGVVQGIITGIRGLCNGLG 465
Cdd:cd17477 251 D-RRRVLLGCALlgALAALLLPLVPGLPLALLVLLFLWGGAAGPlYTLALALAGDRLPGDELVAANAALLLLYGLGSVIG 329
|
330
....*....|.
gi 2052141748 466 PALYGFIFFLF 476
Cdd:cd17477 330 PLLAGALMDAF 340
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
163-266 |
4.65e-03 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 39.48 E-value: 4.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 163 FLSFMSAPLIGA-LSDVWGRKSFLLVTVF-FTCVPIPL-MRISPWWYFAMISVSGVFSVTFSVIFA-YVADITQEHERST 238
Cdd:cd17323 44 VLGFGLGPLIWApLSELYGRRPVYLVSLFiFVIFQIGCaLAPNIAMLIILRFLQGFFGSSPLAIGAgTIADLFTPEERGK 123
|
90 100
....*....|....*....|....*....
gi 2052141748 239 AYGLVS-ATFAASLVtSPAIGAYLSASKG 266
Cdd:cd17323 124 AMGVYSlGPLLGPAL-GPIIGGFITQSLG 151
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
170-525 |
6.54e-03 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 39.15 E-value: 6.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 170 PLIGALSDV----WG-RKSFLLVTVFFTCVPIPLMRISPWWYFAMISVSGVFSVTFSVIF----------------AYVA 228
Cdd:cd17313 52 PLVGSLSDRcnsrIGrRRPFILVGAPLAALGLILIPNAADIGLALGDGPRTWALVLFVLGivlldfamnvcqgpvrALLP 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 229 DITQEHERSTAYGLVSATFAASLVTSPAIGAYLSASK------GDNLVVLVATVVAVLDICFI--LLAVPEslpEKMRPA 300
Cdd:cd17313 132 DLVPPEQRSKANGIINFMGGLGGVLGYLLGAILWDHNwfgfalGGNLKVPFYIGAIILLVCVLvtLFFVKE---PPLSPE 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 301 SWGAPISWEQADPFASLKKV--GKDSTVLLICITVFLSYLpeAGQYSSFF--LYLRQIIGFGPATIAAFIAV---VGILS 373
Cdd:cd17313 209 AGEHSENPSLGEVLKSLLKLlkIMPRSLLRLLLVIFFWWI--AFFPFELFftDYMGEEVYHGTSAASSHYGAgvrMGAWG 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 374 IIAQTVFLSI-------LMRSIGNKNTVLLGLGFQMLQLTWYGFGSQPW----MMWAAGAV-AAMSSITFPAISALVSRN 441
Cdd:cd17313 287 LLIFSLAFLIfslpigkLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTvalvLFALGGIGwATININPYPLVSDYHSES 366
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052141748 442 AEpdQQGVVQGIITGIRGLCNGLGPALYGFIFFLFHVelnelapvqssdkntmqdpsdekaiipGPPFLFGACAVLLAFL 521
Cdd:cd17313 367 GR--GQGTDTGLLNLAISLAQILVSLLAGPIIDVKGY---------------------------GTVFPVAAVASFLSLV 417
|
....
gi 2052141748 522 VALF 525
Cdd:cd17313 418 GALF 421
|
|
| |
