|
Name |
Accession |
Description |
Interval |
E-value |
| MCM6 |
cd17757 |
DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in ... |
40-346 |
0e+00 |
|
DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.
Pssm-ID: 350663 [Multi-domain] Cd Length: 307 Bit Score: 654.44 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 40 NLCTSLFPTIHGNDEVKRGVLLMLFGGVPKTTSEGTSLRGDINVCVVGDPSTAKSQFLKHVDEFSPRAVYTSGKASSAAG 119
Cdd:cd17757 1 NLVRSIAPSIYGHEEVKKGILLMLLGGVHKITREGISLRGDINVCIVGDPSTAKSQFLKYVEEFSPRAVYTSGKASSAAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 120 LTAAVVKDEESHEFVIEAGALMLADNGVCCIDEFDKMDVRDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPVGG 199
Cdd:cd17757 81 LTAAVVRDEETGDFVIEAGALMLADNGICCIDEFDKMDIKDQVAIHEAMEQQTISITKAGIQATLNARTSILAAANPVGG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 200 RYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHSRVEESVDRVYSLDDIRRYLLFARQFKPKISK 279
Cdd:cd17757 161 RYDRSKSLKQNINISAPIMSRFDLFFVLLDECNEVTDYAIASHIVDLHSKREEAIEPPFTAEQLKRYIAYARTFKPKLTK 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 676702896 280 ESEDFIVEQYKRLRQRDGSGVTKSSWRITVRQLESMIRLSEAMARMHCCDEVHPKHVKEAFRLLNKS 346
Cdd:cd17757 241 EAKDELVEQYKELRQDDASGSTRSSYRITVRQLESLIRLSEAIARLHCSDEVTPEHVEEAARLLKKS 307
|
|
| MCM |
smart00350 |
minichromosome maintenance proteins; |
14-348 |
0e+00 |
|
minichromosome maintenance proteins;
Pssm-ID: 214631 [Multi-domain] Cd Length: 509 Bit Score: 528.37 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 14 ESIKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGVLLMLFGGVPKTTSEGTSLRGDINVCVVGDPSTAK 93
Cdd:smart00350 170 SFSVQSLSDEEEEEIRKLSKDPDIYERLARSLAPSIYGHEDIKKAILLLLFGGVHKNLPDGMKIRGDINILLCGDPGTAK 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 94 SQFLKHVDEFSPRAVYTSGKASSAAGLTAAVVKDEESHEFVIEAGALMLADNGVCCIDEFDKMDVRDQVAIHEAMEQQTI 173
Cdd:smart00350 250 SQLLKYVEKTAPRAVYTTGKGSSAVGLTAAVTRDPETREFTLEAGALVLADNGVCCIDEFDKMDDSDRTAIHEAMEQQTI 329
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 174 SITKAGVKATLNARTSILAAANPVGGRYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLH----SR 249
Cdd:smart00350 330 SIAKAGITTTLNARCSVLAAANPIGGRYDPKLTPEENIDLPAPILSRFDLLFVVLDEVDEERDRELAKHVVDLHryshPE 409
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 250 VEESVDRVYSLDDIRRYLLFAR-QFKPKISKESEDFIVEQYKRLRQRDGSGVTKSSWRITVRQLESMIRLSEAMARMHCC 328
Cdd:smart00350 410 EDEAFEPPLSQEKLRKYIAYAReKIKPKLSEEAADKLVKAYVDLRKEDSQTESRSSIPITVRQLESIIRLSEAHAKMRLS 489
|
330 340
....*....|....*....|
gi 676702896 329 DEVHPKHVKEAFRLLNKSII 348
Cdd:smart00350 490 DVVEEADVEEAIRLLRESII 509
|
|
| MCM |
pfam00493 |
MCM P-loop domain; |
24-247 |
3.16e-144 |
|
MCM P-loop domain;
Pssm-ID: 459830 [Multi-domain] Cd Length: 224 Bit Score: 413.08 E-value: 3.16e-144
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 24 EWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGVLLMLFGGVPKTTSEGTSLRGDINVCVVGDPSTAKSQFLKHVDEF 103
Cdd:pfam00493 1 DEEEIKELAKRPDIYDKLADSIAPSIYGHEDVKKAILLQLFGGVKKILPDGTRLRGDINVLLVGDPGTAKSQLLKYVEKI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 104 SPRAVYTSGKASSAAGLTAAVVKDEESHEFVIEAGALMLADNGVCCIDEFDKMDVRDQVAIHEAMEQQTISITKAGVKAT 183
Cdd:pfam00493 81 APRAVYTSGKGSSAAGLTAAVVRDPVTGEFVLEAGALVLADGGVCCIDEFDKMNDEDRVALHEAMEQQTISIAKAGIVAT 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 676702896 184 LNARTSILAAANPVGGRYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLH 247
Cdd:pfam00493 161 LNARCSILAAANPIFGRYDPKKSIAENINLPPPLLSRFDLIFVLLDKPDEEKDERLAKHIVDLH 224
|
|
| minchrom_main_MCM |
NF040949 |
minichromosome maintenance protein MCM; |
26-358 |
5.72e-131 |
|
minichromosome maintenance protein MCM;
Pssm-ID: 468880 [Multi-domain] Cd Length: 681 Bit Score: 395.83 E-value: 5.72e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 26 EKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGVLLMLFGGVPKTTSEGTSLRGDINVCVVGDPSTAKSQFLKHVDEFSP 105
Cdd:NF040949 270 EKILELAKDPWIREKIIASIAPSIYGHWEIKEAIALLLFGGVPKVLPDGTRIRGDIHVLIVGDPGTAKSQLLQYVARLAP 349
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 106 RAVYTSGKASSAAGLTAAVVKDEESHEFVIEAGALMLADNGVCCIDEFDKMDVRDQVAIHEAMEQQTISITKAGVKATLN 185
Cdd:NF040949 350 RAVYTSGKGSTAAGLTAAVVRDKLTGEYYLEAGALVLADGGVAVIDEIDKMREEDRSAIHEAMEQQTVSIAKAGIVATLN 429
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 186 ARTSILAAANPVGGRYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHSRVEESVDRVySLDDIRR 265
Cdd:NF040949 430 ARASVLAAGNPKFGRYDPNRSVAENIDLPPTILSRFDLIFVIRDKPNEERDRRLARHILDVHSGKEKVKPEI-DPDLLKK 508
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 266 YLLFARQF-KPKISKESEDFIVEQYKRLRQRDGSGVTKSS-WRITVRQLESMIRLSEAMARMHCCDEVHPKHVKEAFRL- 342
Cdd:NF040949 509 YIAYARKYvRPKLTEEAKKLIEDFYVEMRKSSKSSEDPDSpIPITARQLEALIRLSEAHAKMRLKDEVTAEDAERAIRLm 588
|
330
....*....|....*....
gi 676702896 343 ---LNKSIIRVETPDINLD 358
Cdd:NF040949 589 lafLESVGIDVETGKIDID 607
|
|
| Mcm2 |
COG1241 |
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ... |
4-358 |
1.90e-130 |
|
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];
Pssm-ID: 440854 [Multi-domain] Cd Length: 682 Bit Score: 394.55 E-value: 1.90e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 4 KELRDEEQTAEsiknqmtvkEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGVLLMLFGGVPKTTSEGTSLRGDINV 83
Cdd:COG1241 248 KEFEEIEITEE---------DEEKIKELSKDPDIYEKIIASIAPSIYGYEEIKEAIALQLFGGVPKVLPDGSRIRGDIHI 318
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 84 CVVGDPSTAKSQFLKHVDEFSPRAVYTSGKASSAAGLTAAVVKDEESH-EFVIEAGALMLADNGVCCIDEFDKMDVRDQV 162
Cdd:COG1241 319 LLVGDPGTAKSQLLRYAARLAPRGVYTSGKGSTAAGLTAAAVRDDFGTgRWTLEAGALVLADGGLACIDELDKMREEDRS 398
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 163 AIHEAMEQQTISITKAGVKATLNARTSILAAANPVGGRYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARR 242
Cdd:COG1241 399 ALHEAMEQQTISIAKAGIVATLNARCSVLAAANPKYGRFDPYEPIAEQIDLPPTLLSRFDLIFVLRDKPDEERDRELARH 478
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 243 IVDLHSRVE----------ESVDRVYSLDDIRRYLLFARQF-KPKISKESEDFIVEQYKRLRQR---DGSGVTksswrIT 308
Cdd:COG1241 479 ILKVHRAGElleqeieeetEEVKPEIDPDLLRKYIAYARRNvFPVLTEEAKDLIEDFYVDMRKKgedEDSPVP-----IT 553
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 676702896 309 VRQLESMIRLSEAMARMHCCDEVHPKHVKEAFRL----LNKSIIRVETPDINLD 358
Cdd:COG1241 554 ARQLEALIRLAEASARMRLSDTVTEEDAERAIRLvdscLKDVGVDPETGKFDID 607
|
|
| PTZ00111 |
PTZ00111 |
DNA replication licensing factor MCM4; Provisional |
17-371 |
2.91e-80 |
|
DNA replication licensing factor MCM4; Provisional
Pssm-ID: 173403 [Multi-domain] Cd Length: 915 Bit Score: 268.40 E-value: 2.91e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 17 KNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGVLLMLFGGVPKTTSEGTS---------LRGDINVCVVG 87
Cdd:PTZ00111 420 ENDFSDLQVYKILELSRNPMIYRILLDSFAPSIKARNNVKIGLLCQLFSGNKNSSDFNKSpdacykvdnFRGIINVLLCG 499
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 88 DPSTAKSQFLKHVDEFSPRAVYTSGKASSAAGLTAAV-VKDEESHEFVIEAGALMLADNGVCCIDEFDKMDVRDQVAIHE 166
Cdd:PTZ00111 500 DPGTAKSQLLHYTHLLSPRSIYTSGKSSSSVGLTASIkFNESDNGRAMIQPGAVVLANGGVCCIDELDKCHNESRLSLYE 579
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 167 AMEQQTISITKAGVKATLNARTSILAAANPVGGRYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARRIV-- 244
Cdd:PTZ00111 580 VMEQQTVTIAKAGIVATLKAETAILASCNPINSRYNKNKAVIENINISPSLFTRFDLIYLVLDHIDQDTDQLISLSIAkd 659
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 245 -------------DLHSR-----VEESV---DRVYSLDD---IRRYLLFAR-QFKPKISKESEDFIVEQYKRLRQ----- 294
Cdd:PTZ00111 660 fllphmtgsgndeDTYDRsntmhVEDESlrsEKDYNKNDldmLRMYIKFSKlHCFPKLSDEAKKVITREYVKMRQgnfqt 739
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 295 -------------RDGSGVTKSSWR---ITVRQLESMIRLSEAMARMHCCDEVHPKHVKEAFRLLN----KSIIRVETPD 354
Cdd:PTZ00111 740 snldelehaqeddDDDLYYQSSGTRmiyVSSRMISSIIRISVSLARMRLSTVVTPADALQAVQIVKsstfQSLVDPTTGK 819
|
410
....*....|....*..
gi 676702896 355 INLDQDDEQQMEDQEDQ 371
Cdd:PTZ00111 820 IDFDQLHQGITTNKMQQ 836
|
|
| MCM6_C |
pfam18263 |
MCM6 C-terminal winged-helix domain; The minichromosome maintenance (Mcm) complex is the ... |
408-511 |
7.26e-26 |
|
MCM6 C-terminal winged-helix domain; The minichromosome maintenance (Mcm) complex is the replicative helicase in eukaryotic species, that plays essential roles in the initiation and elongation phases of DNA replication. During late M and early G(1), the Mcm complex is loaded onto chromatin to form prereplicative complex in a Cdt1-dependent manner. This entry represents the C-terminal domain of human Mcm6 which is the Cdt1 binding domain (CBD). The structure of CBD exhibits a typical winged helix fold that is generally involved in protein-nucleic acid interaction. The CBD failed to interact with DNA in experiments. The CBD-Cdt1 interaction involves the helix-turn-helix motif of CBD.
Pssm-ID: 465688 Cd Length: 107 Bit Score: 101.51 E-value: 7.26e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 408 LRLGFSEYRRISNLLVLHLRKAEEEEDDSsLKRSELINWYLKEIESEIESEEQLINKKKIIERVIHRLTHyDHILIELSQ 487
Cdd:pfam18263 3 LRITYDKYVKIMNLLVLHLREVEEEEGEG-VDRSELIQWYLEQIEDEIESEEELEEEKELVEKVIKRLIK-DNILLEIRG 80
|
90 100
....*....|....*....|....*
gi 676702896 488 SGLRGSREE-ETFDEDPYLVVNPNY 511
Cdd:pfam18263 81 EGLEDEGEEdAEEEEDPVLVVHPNY 105
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MCM6 |
cd17757 |
DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in ... |
40-346 |
0e+00 |
|
DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.
Pssm-ID: 350663 [Multi-domain] Cd Length: 307 Bit Score: 654.44 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 40 NLCTSLFPTIHGNDEVKRGVLLMLFGGVPKTTSEGTSLRGDINVCVVGDPSTAKSQFLKHVDEFSPRAVYTSGKASSAAG 119
Cdd:cd17757 1 NLVRSIAPSIYGHEEVKKGILLMLLGGVHKITREGISLRGDINVCIVGDPSTAKSQFLKYVEEFSPRAVYTSGKASSAAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 120 LTAAVVKDEESHEFVIEAGALMLADNGVCCIDEFDKMDVRDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPVGG 199
Cdd:cd17757 81 LTAAVVRDEETGDFVIEAGALMLADNGICCIDEFDKMDIKDQVAIHEAMEQQTISITKAGIQATLNARTSILAAANPVGG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 200 RYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHSRVEESVDRVYSLDDIRRYLLFARQFKPKISK 279
Cdd:cd17757 161 RYDRSKSLKQNINISAPIMSRFDLFFVLLDECNEVTDYAIASHIVDLHSKREEAIEPPFTAEQLKRYIAYARTFKPKLTK 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 676702896 280 ESEDFIVEQYKRLRQRDGSGVTKSSWRITVRQLESMIRLSEAMARMHCCDEVHPKHVKEAFRLLNKS 346
Cdd:cd17757 241 EAKDELVEQYKELRQDDASGSTRSSYRITVRQLESLIRLSEAIARLHCSDEVTPEHVEEAARLLKKS 307
|
|
| MCM |
smart00350 |
minichromosome maintenance proteins; |
14-348 |
0e+00 |
|
minichromosome maintenance proteins;
Pssm-ID: 214631 [Multi-domain] Cd Length: 509 Bit Score: 528.37 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 14 ESIKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGVLLMLFGGVPKTTSEGTSLRGDINVCVVGDPSTAK 93
Cdd:smart00350 170 SFSVQSLSDEEEEEIRKLSKDPDIYERLARSLAPSIYGHEDIKKAILLLLFGGVHKNLPDGMKIRGDINILLCGDPGTAK 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 94 SQFLKHVDEFSPRAVYTSGKASSAAGLTAAVVKDEESHEFVIEAGALMLADNGVCCIDEFDKMDVRDQVAIHEAMEQQTI 173
Cdd:smart00350 250 SQLLKYVEKTAPRAVYTTGKGSSAVGLTAAVTRDPETREFTLEAGALVLADNGVCCIDEFDKMDDSDRTAIHEAMEQQTI 329
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 174 SITKAGVKATLNARTSILAAANPVGGRYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLH----SR 249
Cdd:smart00350 330 SIAKAGITTTLNARCSVLAAANPIGGRYDPKLTPEENIDLPAPILSRFDLLFVVLDEVDEERDRELAKHVVDLHryshPE 409
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 250 VEESVDRVYSLDDIRRYLLFAR-QFKPKISKESEDFIVEQYKRLRQRDGSGVTKSSWRITVRQLESMIRLSEAMARMHCC 328
Cdd:smart00350 410 EDEAFEPPLSQEKLRKYIAYAReKIKPKLSEEAADKLVKAYVDLRKEDSQTESRSSIPITVRQLESIIRLSEAHAKMRLS 489
|
330 340
....*....|....*....|
gi 676702896 329 DEVHPKHVKEAFRLLNKSII 348
Cdd:smart00350 490 DVVEEADVEEAIRLLRESII 509
|
|
| MCM |
pfam00493 |
MCM P-loop domain; |
24-247 |
3.16e-144 |
|
MCM P-loop domain;
Pssm-ID: 459830 [Multi-domain] Cd Length: 224 Bit Score: 413.08 E-value: 3.16e-144
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 24 EWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGVLLMLFGGVPKTTSEGTSLRGDINVCVVGDPSTAKSQFLKHVDEF 103
Cdd:pfam00493 1 DEEEIKELAKRPDIYDKLADSIAPSIYGHEDVKKAILLQLFGGVKKILPDGTRLRGDINVLLVGDPGTAKSQLLKYVEKI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 104 SPRAVYTSGKASSAAGLTAAVVKDEESHEFVIEAGALMLADNGVCCIDEFDKMDVRDQVAIHEAMEQQTISITKAGVKAT 183
Cdd:pfam00493 81 APRAVYTSGKGSSAAGLTAAVVRDPVTGEFVLEAGALVLADGGVCCIDEFDKMNDEDRVALHEAMEQQTISIAKAGIVAT 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 676702896 184 LNARTSILAAANPVGGRYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLH 247
Cdd:pfam00493 161 LNARCSILAAANPIFGRYDPKKSIAENINLPPPLLSRFDLIFVLLDKPDEEKDERLAKHIVDLH 224
|
|
| MCM |
cd17706 |
MCM helicase family; MCM helicases are a family of helicases that play an important role in ... |
44-343 |
7.97e-143 |
|
MCM helicase family; MCM helicases are a family of helicases that play an important role in replication and homologous recombination repair. The heterohexameric ring-shaped Mcm2-7 complex is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases. Mcm8 and Mcm9, form a complex required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).
Pssm-ID: 350658 [Multi-domain] Cd Length: 311 Bit Score: 412.89 E-value: 7.97e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 44 SLFPTIHGNDEVKRGVLLMLFGGVPKTTSEGTSLRGDINVCVVGDPSTAKSQFLKHVDEFSPRAVYTSGKASSAAGLTAA 123
Cdd:cd17706 5 SIAPSIYGHEDVKKAVLLQLFGGVQKILEDGTRIRGDIHILLVGDPGTAKSQILKYVLKIAPRGVYTSGKGSSGAGLTAA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 124 VVKDEESHEFVIEAGALMLADNGVCCIDEFDKMDVRDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPVGGRYDR 203
Cdd:cd17706 85 VVRDSETGEWYLEAGALVLADGGVCCIDEFDKMKELDRTALHEAMEQQTISIAKAGIVTTLNARCSILAAANPKGGRYNP 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 204 SKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHSRVEESVDRVYSLDDI-------RRYLLFARQFKPK 276
Cdd:cd17706 165 KLSPIENINLPSPLLSRFDLIFVIRDDPDEERDEELAEHIIDLHRGSDPEEQVKPEEDGIpidiellRKYILYARQIHPK 244
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 676702896 277 ISKESEDFIVEQYKRLRQRDgsgVTKSSWRITVRQLESMIRLSEAMARMHCCDEVHPKHVKEAFRLL 343
Cdd:cd17706 245 ISEEAREKLVRWYVELRKES---ERRSTIPITARQLESVIRLAEAHAKMRLSEVVTEEDVEEAIRLV 308
|
|
| minchrom_main_MCM |
NF040949 |
minichromosome maintenance protein MCM; |
26-358 |
5.72e-131 |
|
minichromosome maintenance protein MCM;
Pssm-ID: 468880 [Multi-domain] Cd Length: 681 Bit Score: 395.83 E-value: 5.72e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 26 EKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGVLLMLFGGVPKTTSEGTSLRGDINVCVVGDPSTAKSQFLKHVDEFSP 105
Cdd:NF040949 270 EKILELAKDPWIREKIIASIAPSIYGHWEIKEAIALLLFGGVPKVLPDGTRIRGDIHVLIVGDPGTAKSQLLQYVARLAP 349
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 106 RAVYTSGKASSAAGLTAAVVKDEESHEFVIEAGALMLADNGVCCIDEFDKMDVRDQVAIHEAMEQQTISITKAGVKATLN 185
Cdd:NF040949 350 RAVYTSGKGSTAAGLTAAVVRDKLTGEYYLEAGALVLADGGVAVIDEIDKMREEDRSAIHEAMEQQTVSIAKAGIVATLN 429
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 186 ARTSILAAANPVGGRYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHSRVEESVDRVySLDDIRR 265
Cdd:NF040949 430 ARASVLAAGNPKFGRYDPNRSVAENIDLPPTILSRFDLIFVIRDKPNEERDRRLARHILDVHSGKEKVKPEI-DPDLLKK 508
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 266 YLLFARQF-KPKISKESEDFIVEQYKRLRQRDGSGVTKSS-WRITVRQLESMIRLSEAMARMHCCDEVHPKHVKEAFRL- 342
Cdd:NF040949 509 YIAYARKYvRPKLTEEAKKLIEDFYVEMRKSSKSSEDPDSpIPITARQLEALIRLSEAHAKMRLKDEVTAEDAERAIRLm 588
|
330
....*....|....*....
gi 676702896 343 ---LNKSIIRVETPDINLD 358
Cdd:NF040949 589 lafLESVGIDVETGKIDID 607
|
|
| Mcm2 |
COG1241 |
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ... |
4-358 |
1.90e-130 |
|
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];
Pssm-ID: 440854 [Multi-domain] Cd Length: 682 Bit Score: 394.55 E-value: 1.90e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 4 KELRDEEQTAEsiknqmtvkEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGVLLMLFGGVPKTTSEGTSLRGDINV 83
Cdd:COG1241 248 KEFEEIEITEE---------DEEKIKELSKDPDIYEKIIASIAPSIYGYEEIKEAIALQLFGGVPKVLPDGSRIRGDIHI 318
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 84 CVVGDPSTAKSQFLKHVDEFSPRAVYTSGKASSAAGLTAAVVKDEESH-EFVIEAGALMLADNGVCCIDEFDKMDVRDQV 162
Cdd:COG1241 319 LLVGDPGTAKSQLLRYAARLAPRGVYTSGKGSTAAGLTAAAVRDDFGTgRWTLEAGALVLADGGLACIDELDKMREEDRS 398
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 163 AIHEAMEQQTISITKAGVKATLNARTSILAAANPVGGRYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARR 242
Cdd:COG1241 399 ALHEAMEQQTISIAKAGIVATLNARCSVLAAANPKYGRFDPYEPIAEQIDLPPTLLSRFDLIFVLRDKPDEERDRELARH 478
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 243 IVDLHSRVE----------ESVDRVYSLDDIRRYLLFARQF-KPKISKESEDFIVEQYKRLRQR---DGSGVTksswrIT 308
Cdd:COG1241 479 ILKVHRAGElleqeieeetEEVKPEIDPDLLRKYIAYARRNvFPVLTEEAKDLIEDFYVDMRKKgedEDSPVP-----IT 553
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 676702896 309 VRQLESMIRLSEAMARMHCCDEVHPKHVKEAFRL----LNKSIIRVETPDINLD 358
Cdd:COG1241 554 ARQLEALIRLAEASARMRLSDTVTEEDAERAIRLvdscLKDVGVDPETGKFDID 607
|
|
| MCM5 |
cd17756 |
DNA replication licensing factor Mcm5; Mcm5 is a helicase that play an important role in ... |
40-346 |
6.06e-128 |
|
DNA replication licensing factor Mcm5; Mcm5 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.
Pssm-ID: 350662 [Multi-domain] Cd Length: 317 Bit Score: 375.18 E-value: 6.06e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 40 NLCTSLFPTIHGNDEVKRGVLLMLFGGVPKTTSEGTSLRGDINVCVVGDPSTAKSQFLKHVDEFSPRAVYTSGKASSAAG 119
Cdd:cd17756 1 IISKSIAPSIYGNEDIKKAIACLLFGGSRKRLPDGMRLRGDINVLLLGDPGTAKSQLLKFVEKVAPIGVYTSGKGSSAAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 120 LTAAVVKDEESHEFVIEAGALMLADNGVCCIDEFDKMDVRDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPVGG 199
Cdd:cd17756 81 LTASVMRDPSTREFYLEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRTSVLAAANPVFG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 200 RYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLH-----SRVEESVDRVYSLDDIRRYLLFAR-QF 273
Cdd:cd17756 161 RYDDLKTPGDNIDFQTTILSRFDMIFIVKDKHDEERDITIAKHVINIHasarkASQSQENEGEIPISKLKRYIAYCRaKC 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 676702896 274 KPKISKESEDFIVEQY----KRLRQRDGSGVTKSSWRITVRQLESMIRLSEAMARMHCCDEVHPKHVKEAFRLLNKS 346
Cdd:cd17756 241 APRLSEEAAEKLSNHYvtirKDVRQNELESDNRSSIPITVRQLEAIIRISESLAKMELSPIATEKHVEEAIRLFQVS 317
|
|
| MCM4 |
cd17755 |
DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in ... |
41-343 |
3.82e-119 |
|
DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.
Pssm-ID: 350661 [Multi-domain] Cd Length: 309 Bit Score: 352.51 E-value: 3.82e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 41 LCTSLFPTIHGNDEVKRGVLLMLFGGVPKT-TSEGTSLRGDINVCVVGDPSTAKSQFLKHVDEFSPRAVYTSGKASSAAG 119
Cdd:cd17755 2 LARSIAPSIYELEDVKKGILLQLFGGTRKDfTKTGGKYRGDINILLCGDPGTSKSQLLQYVHKISPRGVYTSGKGSSAVG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 120 LTAAVVKDEESHEFVIEAGALMLADNGVCCIDEFDKMDVRDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPVGG 199
Cdd:cd17755 82 LTAYVTRDPDTKQLVLESGALVLSDGGICCIDEFDKMSDSTRSVLHEVMEQQTLSIAKAGIITTLNARTSILASANPIGS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 200 RYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLH--SRVEESVDRVYSLDDIRRYLLFARQ-FKPK 276
Cdd:cd17755 162 RYNPKLTVVENIDLPPTLLSRFDLIYLVLDKVDEKYDRRLAKHLVSLYleDTPEHIQDEVLDVEVLTDYISYAREhIHPK 241
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 676702896 277 ISKESEDFIVEQYKRLRQRdGSGVTKsswRITV--RQLESMIRLSEAMARMHCCDEVHPKHVKEAFRLL 343
Cdd:cd17755 242 LSEEAAQELVQAYVDMRKM-GSDARK---RITAtpRQLESLIRLAEAHAKMRLSNVVEAEDVEEAVRLI 306
|
|
| MCM_arch |
cd17761 |
archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the ... |
44-343 |
7.73e-119 |
|
archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the eukaryotic Mcm2-7 helicase and also function as the replicative helicase at the replication fork
Pssm-ID: 350667 [Multi-domain] Cd Length: 308 Bit Score: 351.75 E-value: 7.73e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 44 SLFPTIHGNDEVKRGVLLMLFGGVPKTTSEGTSLRGDINVCVVGDPSTAKSQFLKHVDEFSPRAVYTSGKASSAAGLTAA 123
Cdd:cd17761 6 SIAPSIYGHEDVKEAIALQLFGGVPKVLPDGTRIRGDIHILLVGDPGTAKSQLLKYVSKVAPRAVYTTGKGSTAAGLTAA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 124 VVKDEESHEFVIEAGALMLADNGVCCIDEFDKMDVRDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPVGGRYDR 203
Cdd:cd17761 86 VVRDEGTGEWYLEAGALVLADKGIAVVDEIDKMRKEDRSALHEAMEQQTISIAKAGIVATLNARAAVLAAANPKFGRFDS 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 204 SKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHSRVEESVDR-VYSLDDIRRYLLFARQF-KPKISKES 281
Cdd:cd17761 166 YRPVAEQIDLPPTLLSRFDLIFVLKDTPNEEKDRRLANHILDTHSGGEMREIKpEIDPDLLRKYIAYARKNvRPVLTEEA 245
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 676702896 282 EDFIVEQYKRLRQRdGSGvTKSSWRITVRQLESMIRLSEAMARMHCCDEVHPKHVKEAFRLL 343
Cdd:cd17761 246 KQLIKDFYVEMRKS-GQE-TPSPVPITARQLEALVRLSEASARMRLSQEVTLEDAERAIRIM 305
|
|
| MCM2 |
cd17753 |
DNA replication licensing factor Mcm2; Mcm2 is a helicase that play an important role in ... |
44-346 |
1.83e-117 |
|
DNA replication licensing factor Mcm2; Mcm2 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.
Pssm-ID: 350659 [Multi-domain] Cd Length: 325 Bit Score: 348.67 E-value: 1.83e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 44 SLFPTIHGNDEVKRGVLLMLFGGVPKTTSEGTSLRGDINVCVVGDPSTAKSQFLKHVDEFSPRAVYTSGKASSAAGLTAA 123
Cdd:cd17753 5 SIAPSIYGHDDIKTAIALALFGGVAKNPGGKHRIRGDINVLLLGDPGTAKSQFLKYVEKTAHRAVFTTGQGASAVGLTAS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 124 VVKDEESHEFVIEAGALMLADNGVCCIDEFDKMDVRDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPVGGRYDR 203
Cdd:cd17753 85 VRKDPVTKEWTLEGGALVLADKGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCSVIAAANPIGGRYNP 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 204 SKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHSRVEESVDRVYSLDD--------------------I 263
Cdd:cd17753 165 TLTFAQNVNLTEPILSRFDILCVVRDTVDPEEDERLAKFVVGSHVRSHPENDEDREGEEeknqrqrpketkvepipqelL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 264 RRYLLFARQ-FKPKISKESEDFIVEQYKRLRQRDGSGvtkSSWRITVRQLESMIRLSEAMARMHCCDEVHPKHVKEAFRL 342
Cdd:cd17753 245 RKYIHYAREkVRPKLNQMDMDKVSRVYADLRKESMAT---GSLPITVRHLESIIRISEAHAKMHLREYVSEEDVDMAIRV 321
|
....
gi 676702896 343 LNKS 346
Cdd:cd17753 322 MLDS 325
|
|
| MCM7 |
cd17758 |
DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in ... |
41-346 |
6.49e-113 |
|
DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.
Pssm-ID: 350664 [Multi-domain] Cd Length: 306 Bit Score: 336.30 E-value: 6.49e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 41 LCTSLFPTIHGNDEVKRGVLLMLFGGVPKTtSEGTSLRGDINVCVVGDPSTAKSQFLKHVDEFSPRAVYTSGKASSAAGL 120
Cdd:cd17758 2 LAASIAPEIYGHEDVKKALLLLLVGGVDKR-GDGMKIRGDINICLMGDPGVAKSQLLKYICRIAPRSVYTTGRGSSGVGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 121 TAAVVKDEESHEFVIEAGALMLADNGVCCIDEFDKMDVRDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPVGGR 200
Cdd:cd17758 81 TAAVMKDPVTGEMTLEGGALVLADQGICCIDEFDKMDESDRTAIHEVMEQQTISIAKAGITTTLNARTSILAAANPAYGR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 201 YDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHSRVEESVDRVYSLDD--IRRYLLFARQFKPKIS 278
Cdd:cd17758 161 YNPRRSPEQNINLPAALLSRFDLLFLILDKPDRDNDLRLAEHVTYVHQHNKQPDSDFEPLDPklLRAYIALAKRKRPTVP 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 676702896 279 KESEDFIVEQYKRLRQRdgSGVTKSSWRITVRQLESMIRLSEAMARMHCCDEVHPKHVKEAFRLLNKS 346
Cdd:cd17758 241 PALADYIVQAYVEMRQE--AKRSKDFTFTTPRTLLAILRLSQALARLRLSDSVEIDDVEEALRLMEMS 306
|
|
| MCM3 |
cd17754 |
DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in ... |
41-344 |
2.91e-106 |
|
DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.
Pssm-ID: 350660 [Multi-domain] Cd Length: 299 Bit Score: 319.03 E-value: 2.91e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 41 LCTSLFPTIHGNDEVKRGVLLMLFGGVPKTTSEGTSLRGDINVCVVGDPSTAKSQFLKHVDEFSPRAVYTSGKASSAAGL 120
Cdd:cd17754 2 LSKSLAPSIYGHEYIKKAILLMLLGGVEKNLENGSHLRGDINILLVGDPSVAKSQLLRYVLNTAPLAIATTGRGSSGVGL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 121 TAAVVKDEESHEFVIEAGALMLADNGVCCIDEFDKMDVRDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPVGGR 200
Cdd:cd17754 82 TAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRVAIHEVMEQQTVTIAKAGIHASLNARCSVLAAANPVYGR 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 201 YDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHSRVEEsvdrvyslddIRRYLLFARQ-FKPKISK 279
Cdd:cd17754 162 YDVYKTPMENIGLPDSLLSRFDLLFIVLDDIDEERDRSISEHVLRMHRYIKF----------LRKYIHYAKErIKPKLTQ 231
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 676702896 280 ESEDFIVEQYKRLRQRDGSGVTKS-SWRITVRQLESMIRLSEAMARMHCCDEVHPKHVKEAFRLLN 344
Cdd:cd17754 232 EAAEYIAEEYADLRNDDNTKTDKArTSPITARTLETLIRLATAHAKARLSKTVDKVDAEVALNLLR 297
|
|
| MCM8 |
cd17759 |
DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a ... |
41-346 |
2.97e-89 |
|
DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a complex with Mcm9 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).
Pssm-ID: 350665 [Multi-domain] Cd Length: 289 Bit Score: 275.18 E-value: 2.97e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 41 LCTSLFPTIHGNDEVKRGVLLMLFGGVPKTTSEGT--SLRGDINVCVVGDPSTAKSQFLKHVDEFSPRAVYTSGKASSAA 118
Cdd:cd17759 2 IVNSLCPAIYGHELVKAGLLLSLFGGKQKYADDKNriPIRGDPHVLIVGDPGLGKSQMLQAACNIAPRGVYVCGNTTTTS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 119 GLTAAVVKDEESHEFVIEAGALMLADNGVCCIDEFDKMDVRDQvAIHEAMEQQTISITKAGVKATLNARTSILAAANPVG 198
Cdd:cd17759 82 GLTVTLTKDGRSGDFALEAGALVLGDQGICGIDEFDKMGSQHQ-ALLEAMEQQSVSLAKAGVVCSLPARTSVIAAANPVG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 199 GRYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYaiarrIVDLHSRVeesvdrvyslddIRRYLLFARQF-KPKI 277
Cdd:cd17759 161 GHYNKGKTVSENLKMGPALLSRFDLVFILLDTPSEEHDH-----LLSEHHQL------------LRKYISYARQYvNPVL 223
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 676702896 278 SKESEDFIVEQYKRLRqrdGSGVTKSSWRITVRQLESMIRLSEAMARMHCCDEVHPKHVKEAFRLLNKS 346
Cdd:cd17759 224 SKDASEALQEFYLELR---KQNQLADSSPITTRQLESLIRLTEARARLELREEATKEDAEDVIEIMKES 289
|
|
| MCM9 |
cd17760 |
DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a ... |
41-331 |
3.47e-89 |
|
DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a complex with Mcm8 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).
Pssm-ID: 350666 [Multi-domain] Cd Length: 299 Bit Score: 275.58 E-value: 3.47e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 41 LCTSLFPTIHGNDEVKRGVLLMLFGGVPKTTSEGTSLRGDINVCVVGDPSTAKSQFLKHVDEFSPRAVYTSGKASSAAGL 120
Cdd:cd17760 2 ILASLCPQVFGLYNVKLAVAMVLAGGVQRIDASGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTAGIGSTSAGL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 121 TAAVVKDeeSHEFVIEAGALMLADNGVCCIDEFDKMDVRDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPvGGR 200
Cdd:cd17760 82 TVTAVKD--GGEWNLEAGALVLADGGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNP-KGQ 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 201 YDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHSRVEESvDRVYSLDDIRRYLLFARQFKPKISKE 280
Cdd:cd17760 159 YDPNESISVNIALASPLLSRFDLVLVLLDTKNEDWDRIISSFILENKGEPSKS-SKLWSMEKMRTYFCLIKNLRPVLSDE 237
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 676702896 281 SEDFIVEQYKRLRQRDGsgvtKSSWRITVRQLESMIRLSEAMARMHCCDEV 331
Cdd:cd17760 238 ANAILLRYYQLQRQSDC----RNAARTTIRMLESLIRLAEAHARLMFRETV 284
|
|
| PTZ00111 |
PTZ00111 |
DNA replication licensing factor MCM4; Provisional |
17-371 |
2.91e-80 |
|
DNA replication licensing factor MCM4; Provisional
Pssm-ID: 173403 [Multi-domain] Cd Length: 915 Bit Score: 268.40 E-value: 2.91e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 17 KNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGVLLMLFGGVPKTTSEGTS---------LRGDINVCVVG 87
Cdd:PTZ00111 420 ENDFSDLQVYKILELSRNPMIYRILLDSFAPSIKARNNVKIGLLCQLFSGNKNSSDFNKSpdacykvdnFRGIINVLLCG 499
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 88 DPSTAKSQFLKHVDEFSPRAVYTSGKASSAAGLTAAV-VKDEESHEFVIEAGALMLADNGVCCIDEFDKMDVRDQVAIHE 166
Cdd:PTZ00111 500 DPGTAKSQLLHYTHLLSPRSIYTSGKSSSSVGLTASIkFNESDNGRAMIQPGAVVLANGGVCCIDELDKCHNESRLSLYE 579
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 167 AMEQQTISITKAGVKATLNARTSILAAANPVGGRYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARRIV-- 244
Cdd:PTZ00111 580 VMEQQTVTIAKAGIVATLKAETAILASCNPINSRYNKNKAVIENINISPSLFTRFDLIYLVLDHIDQDTDQLISLSIAkd 659
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 245 -------------DLHSR-----VEESV---DRVYSLDD---IRRYLLFAR-QFKPKISKESEDFIVEQYKRLRQ----- 294
Cdd:PTZ00111 660 fllphmtgsgndeDTYDRsntmhVEDESlrsEKDYNKNDldmLRMYIKFSKlHCFPKLSDEAKKVITREYVKMRQgnfqt 739
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 295 -------------RDGSGVTKSSWR---ITVRQLESMIRLSEAMARMHCCDEVHPKHVKEAFRLLN----KSIIRVETPD 354
Cdd:PTZ00111 740 snldelehaqeddDDDLYYQSSGTRmiyVSSRMISSIIRISVSLARMRLSTVVTPADALQAVQIVKsstfQSLVDPTTGK 819
|
410
....*....|....*..
gi 676702896 355 INLDQDDEQQMEDQEDQ 371
Cdd:PTZ00111 820 IDFDQLHQGITTNKMQQ 836
|
|
| MCM_lid |
pfam17855 |
MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins. |
261-347 |
4.90e-32 |
|
MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins.
Pssm-ID: 465534 [Multi-domain] Cd Length: 86 Bit Score: 118.03 E-value: 4.90e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 261 DDIRRYLLFAR-QFKPKISKESEDFIVEQYKRLRQRDGSGvtKSSWRITVRQLESMIRLSEAMARMHCCDEVHPKHVKEA 339
Cdd:pfam17855 1 ELLRKYIAYAReKIKPKLSEEAREKLVDAYVELRKESTGS--GSSIPITVRQLESLIRLSEAHAKMRLSEIVTEEDVEEA 78
|
....*...
gi 676702896 340 FRLLNKSI 347
Cdd:pfam17855 79 IRLLKESL 86
|
|
| MCM6_C |
pfam18263 |
MCM6 C-terminal winged-helix domain; The minichromosome maintenance (Mcm) complex is the ... |
408-511 |
7.26e-26 |
|
MCM6 C-terminal winged-helix domain; The minichromosome maintenance (Mcm) complex is the replicative helicase in eukaryotic species, that plays essential roles in the initiation and elongation phases of DNA replication. During late M and early G(1), the Mcm complex is loaded onto chromatin to form prereplicative complex in a Cdt1-dependent manner. This entry represents the C-terminal domain of human Mcm6 which is the Cdt1 binding domain (CBD). The structure of CBD exhibits a typical winged helix fold that is generally involved in protein-nucleic acid interaction. The CBD failed to interact with DNA in experiments. The CBD-Cdt1 interaction involves the helix-turn-helix motif of CBD.
Pssm-ID: 465688 Cd Length: 107 Bit Score: 101.51 E-value: 7.26e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 408 LRLGFSEYRRISNLLVLHLRKAEEEEDDSsLKRSELINWYLKEIESEIESEEQLINKKKIIERVIHRLTHyDHILIELSQ 487
Cdd:pfam18263 3 LRITYDKYVKIMNLLVLHLREVEEEEGEG-VDRSELIQWYLEQIEDEIESEEELEEEKELVEKVIKRLIK-DNILLEIRG 80
|
90 100
....*....|....*....|....*
gi 676702896 488 SGLRGSREE-ETFDEDPYLVVNPNY 511
Cdd:pfam18263 81 EGLEDEGEEdAEEEEDPVLVVHPNY 105
|
|
| PRK09862 |
PRK09862 |
ATP-dependent protease; |
136-351 |
1.36e-09 |
|
ATP-dependent protease;
Pssm-ID: 182120 [Multi-domain] Cd Length: 506 Bit Score: 60.38 E-value: 1.36e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 136 EAGALMLADNGVCCIDEFDKMDVRDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANP-----VGGRYDRS---KSL 207
Cdd:PRK09862 286 GPGEISLAHNGVLFLDELPEFERRTLDALREPIESGQIHLSRTRAKITYPARFQLVAAMNPsptghYQGNHNRCtpeQTL 365
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 208 KQNINLSAPIMSRFDLFF-ILVDECNEVTDYAI-ARRIVDLHSRVEESVDRVYSlddiRRYLLFARQFKPKIskesedfi 285
Cdd:PRK09862 366 RYLNRLSGPFLDRFDLSLeIPLPPPGILSKTVVpGESSATVKQRVMAARERQFK----RQNKLNAWLDSPEI-------- 433
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 286 vEQYKRLRQRDGSGVTKSSWR--ITVRQLESMIRLSEAMARMHCCDEVHPKHVKEA--FRLLNKSIIRVE 351
Cdd:PRK09862 434 -RQFCKLESEDARWLEETLIHlgLSIRAWQRLLKVARTIADIDQSDIITRQHLQEAvsYRAIDRLLIHLQ 502
|
|
| Mg_chelatase |
pfam01078 |
Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that ... |
138-225 |
1.05e-04 |
|
Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that catalyzes the insertion of Mg2+ into protoporphyrin IX. This is the first unique step in the synthesis of (bacterio)chlorophyll. Due to this, it is thought that Mg-chelatase has an important role in channelling inter- mediates into the (bacterio)chlorophyll branch in response to conditions suitable for photosynthetic growth. ChlI and BchD have molecular weight between 38-42 kDa.
Pssm-ID: 426032 [Multi-domain] Cd Length: 207 Bit Score: 43.29 E-value: 1.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 138 GALMLADNGVCCIDEFDKMDVRDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANP-------------VGGRYDRS 204
Cdd:pfam01078 100 GEISLAHNGVLFLDELPEFKRRVLESLRQPLEDGEITISRARAKVTFPARFQLVAAMNPcpcgylgdpnkrcRCSPRQIR 179
|
90 100
....*....|....*....|.
gi 676702896 205 KSLKqniNLSAPIMSRFDLFF 225
Cdd:pfam01078 180 RYLS---RLSGPLLDRIDLQV 197
|
|
| MoxR |
COG0714 |
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ... |
127-343 |
2.62e-04 |
|
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis
Pssm-ID: 440478 [Multi-domain] Cd Length: 292 Bit Score: 42.85 E-value: 2.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 127 DEESHEFVIEAGALMladNGVCCIDEFDKMDVRDQVAIHEAMEQQTISItkAGVKATLNARTSILAAANPVG--GRYDrs 204
Cdd:COG0714 80 DQQTGEFEFRPGPLF---ANVLLADEINRAPPKTQSALLEAMEERQVTI--PGGTYKLPEPFLVIATQNPIEqeGTYP-- 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 205 kslkqninLSAPIMSRFdLFFILVD------EcnevtdyaiaRRIVDLH-SRVEESVDRVYSLDDIRRYLLFARQFkpKI 277
Cdd:COG0714 153 --------LPEAQLDRF-LLKLYIGypdaeeE----------REILRRHtGRHLAEVEPVLSPEELLALQELVRQV--HV 211
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 676702896 278 SKESEDFIVEQYKRLRQRDGsgvtkSSWRITVRQLESMIRLSEAMARMHCCDEVHPKHVKEAFRLL 343
Cdd:COG0714 212 SEAVLDYIVDLVRATREHPD-----LRKGPSPRASIALLRAARALALLDGRDYVTPDDVKAVAGPV 272
|
|
| AAA_5 |
pfam07728 |
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ... |
82-221 |
3.47e-03 |
|
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.
Pssm-ID: 400191 [Multi-domain] Cd Length: 135 Bit Score: 37.66 E-value: 3.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676702896 82 NVCVVGDPSTAKSQFLKHVDEF---SPRAVYTSGKASSAAGLTAAVVKDEESHEFVieAGALMLADN--GVCCIDEFDKM 156
Cdd:pfam07728 1 GVLLVGPPGTGKTELAERLAAAlsnRPVFYVQLTRDTTEEDLFGRRNIDPGGASWV--DGPLVRAARegEIAVLDEINRA 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 676702896 157 DVRDQVAIHEAMEQQTISITKAG--VKATLNARtSILAAANPVggryDRSKSlkqniNLSAPIMSRF 221
Cdd:pfam07728 79 NPDVLNSLLSLLDERRLLLPDGGelVKAAPDGF-RLIATMNPL----DRGLN-----ELSPALRSRF 135
|
|
| |
