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Conserved domains on  [gi|1008842571|gb|KYK25796|]
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hypothetical protein AYK26_07640 [Euryarchaeota archaeon SM23-78]

Protein Classification

glycosyltransferase( domain architecture ID 13409205)

glycosyltransferase catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4641 super family cl34798
Spore maturation protein CgeB [Cell cycle control, cell division, chromosome partitioning];
113-303 1.53e-25

Spore maturation protein CgeB [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG4641:

Pssm-ID: 443679 [Multi-domain]  Cd Length: 303  Bit Score: 103.47  E-value: 1.53e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842571 113 DPHVLKRdYRKVMDRYDYRFCMQTPYIEDDE-------YYLPYAYDPELHYPM--DLEKEYDVCLIGLQYPKRIRVLNRL 183
Cdd:COG4641    79 DPVTLDR-FRELLPLYDLVFTFDGDCVEEYRalgarrvFYLPFAADPELHRPVppEARFRYDVAFVGNYYPDRRARLEEL 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842571 184 KSKYVVRDG------------------IGTI-YDEYREEYNKSRVS---FSWSSKRDLPA-RVWESFAMGIPLVTNYVDD 240
Cdd:COG4641   158 LLAPAGLRLkiygpgwpklalpanvrrGGHLpGEEHPAAYASSKITlnvNRMAASPDSPTrRTFEAAACGAFLLSDPWEG 237

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1008842571 241 LSTnlFFHP-THYLHYKTEDEAVEKIEWLLANEDEALEMAHHALKQV-EPHTWDARVEKILKTCE 303
Cdd:COG4641   238 LEE--LFEPgEEVLVFRDGEELAEKLRYLLADPEERRAIAEAGRRRVlAEHTYAHRARELLAILE 300
 
Name Accession Description Interval E-value
COG4641 COG4641
Spore maturation protein CgeB [Cell cycle control, cell division, chromosome partitioning];
113-303 1.53e-25

Spore maturation protein CgeB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443679 [Multi-domain]  Cd Length: 303  Bit Score: 103.47  E-value: 1.53e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842571 113 DPHVLKRdYRKVMDRYDYRFCMQTPYIEDDE-------YYLPYAYDPELHYPM--DLEKEYDVCLIGLQYPKRIRVLNRL 183
Cdd:COG4641    79 DPVTLDR-FRELLPLYDLVFTFDGDCVEEYRalgarrvFYLPFAADPELHRPVppEARFRYDVAFVGNYYPDRRARLEEL 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842571 184 KSKYVVRDG------------------IGTI-YDEYREEYNKSRVS---FSWSSKRDLPA-RVWESFAMGIPLVTNYVDD 240
Cdd:COG4641   158 LLAPAGLRLkiygpgwpklalpanvrrGGHLpGEEHPAAYASSKITlnvNRMAASPDSPTrRTFEAAACGAFLLSDPWEG 237

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1008842571 241 LSTnlFFHP-THYLHYKTEDEAVEKIEWLLANEDEALEMAHHALKQV-EPHTWDARVEKILKTCE 303
Cdd:COG4641   238 LEE--LFEPgEEVLVFRDGEELAEKLRYLLADPEERRAIAEAGRRRVlAEHTYAHRARELLAILE 300
Glyco_trans_1_2 pfam13524
Glycosyl transferases group 1;
218-299 2.10e-15

Glycosyl transferases group 1;


Pssm-ID: 433281 [Multi-domain]  Cd Length: 93  Bit Score: 70.33  E-value: 2.10e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842571 218 DLPARVWESFAMGIPLVTNYVDDLSTnLFFHPTHYLHYKTEDEAVEKIEWLLANEDEALEMAHHALKQV-EPHTWDARVE 296
Cdd:pfam13524  11 SPNMRVFEAAACGAPLLTDRTPGLEE-LFEPGEEILLYRDPEELAEKIRYLLEHPEERRAIAAAGRERVlAEHTYAHRAE 89


                  ...
gi 1008842571 297 KIL 299
Cdd:pfam13524  90 QLL 92
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 225-303 6.83e-05

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 44.07  E-value: 6.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842571 225 ESFAMGIPLVTNYVD------DLSTNLFFHPThylhyKTEDEAVEKIEWLLANEDEALEMAHHALKQVEPH-TWDARVEK 297
Cdd:cd03801   286 EAMAAGLPVVATDVGglpevvEDGEGGLVVPP-----DDVEALADALLRLLADPELRARLGRAARERVAERfSWERVAER 360


                  ....*.
gi 1008842571 298 ILKTCE 303
Cdd:cd03801   361 LLDLYR 366
 
Name Accession Description Interval E-value
COG4641 COG4641
Spore maturation protein CgeB [Cell cycle control, cell division, chromosome partitioning];
113-303 1.53e-25

Spore maturation protein CgeB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443679 [Multi-domain]  Cd Length: 303  Bit Score: 103.47  E-value: 1.53e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842571 113 DPHVLKRdYRKVMDRYDYRFCMQTPYIEDDE-------YYLPYAYDPELHYPM--DLEKEYDVCLIGLQYPKRIRVLNRL 183
Cdd:COG4641    79 DPVTLDR-FRELLPLYDLVFTFDGDCVEEYRalgarrvFYLPFAADPELHRPVppEARFRYDVAFVGNYYPDRRARLEEL 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842571 184 KSKYVVRDG------------------IGTI-YDEYREEYNKSRVS---FSWSSKRDLPA-RVWESFAMGIPLVTNYVDD 240
Cdd:COG4641   158 LLAPAGLRLkiygpgwpklalpanvrrGGHLpGEEHPAAYASSKITlnvNRMAASPDSPTrRTFEAAACGAFLLSDPWEG 237

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1008842571 241 LSTnlFFHP-THYLHYKTEDEAVEKIEWLLANEDEALEMAHHALKQV-EPHTWDARVEKILKTCE 303
Cdd:COG4641   238 LEE--LFEPgEEVLVFRDGEELAEKLRYLLADPEERRAIAEAGRRRVlAEHTYAHRARELLAILE 300
Glyco_trans_1_2 pfam13524
Glycosyl transferases group 1;
218-299 2.10e-15

Glycosyl transferases group 1;


Pssm-ID: 433281 [Multi-domain]  Cd Length: 93  Bit Score: 70.33  E-value: 2.10e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842571 218 DLPARVWESFAMGIPLVTNYVDDLSTnLFFHPTHYLHYKTEDEAVEKIEWLLANEDEALEMAHHALKQV-EPHTWDARVE 296
Cdd:pfam13524  11 SPNMRVFEAAACGAPLLTDRTPGLEE-LFEPGEEILLYRDPEELAEKIRYLLEHPEERRAIAAAGRERVlAEHTYAHRAE 89


                  ...
gi 1008842571 297 KIL 299
Cdd:pfam13524  90 QLL 92
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 204-300 2.91e-06

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 45.75  E-value: 2.91e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842571 204 YNKSRVSFSWSSKRDLPARVWESFAMGIPLVT-------NYVDDLSTNLFFHPthylhyKTEDEAVEKIEWLLANEDEAL 276
Cdd:COG0438    18 LAAADVFVLPSRSEGFGLVLLEAMAAGLPVIAtdvgglpEVIEDGETGLLVPP------GDPEALAEAILRLLEDPELRR 91

                          90       100
                  ....*....|....*....|....*
gi 1008842571 277 EMAHHALKQVEPH-TWDARVEKILK 300
Cdd:COG0438    92 RLGEAARERAEERfSWEAIAERLLA 116
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 225-303 6.83e-05

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 44.07  E-value: 6.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842571 225 ESFAMGIPLVTNYVD------DLSTNLFFHPThylhyKTEDEAVEKIEWLLANEDEALEMAHHALKQVEPH-TWDARVEK 297
Cdd:cd03801   286 EAMAAGLPVVATDVGglpevvEDGEGGLVVPP-----DDVEALADALLRLLADPELRARLGRAARERVAERfSWERVAER 360


                  ....*.
gi 1008842571 298 ILKTCE 303
Cdd:cd03801   361 LLDLYR 366
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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