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Conserved domains on  [gi|1011615769|gb|KYO49198|]
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hypothetical protein Y1Q_0013282 [Alligator mississippiensis]

Protein Classification

ZIP family transporter( domain architecture ID 579)

ZIP family transporter may function as a zinc transporter, mediating the uptake of zinc in bacteria or the transport of zinc from one cellular compartment to another in eukaryotes

Gene Ontology:  GO:0046873|GO:0030001
PubMed:  23046653|10748254
TCDB:  2.A.5

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Zip super family cl00437
ZIP Zinc transporter; The ZIP family consists of zinc transport proteins and many putative ...
 1-71 1.96e-10

ZIP Zinc transporter; The ZIP family consists of zinc transport proteins and many putative metal transporters. The main contribution to this family is from the Arabidopsis thaliana ZIP protein family these proteins are responsible for zinc uptake in the plant. Also found within this family are C. elegans proteins of unknown function which are annotated as being similar to human growth arrest inducible gene product, although this protein in not found within this family.


The actual alignment was detected with superfamily member pfam02535:

Pssm-ID: 444905 [Multi-domain]  Cd Length: 325  Bit Score: 54.30  E-value: 1.96e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1011615769   1 MSPLGIVLGMGL-SQSRGPSAALAQCLLQGLAAGTFLYVTFLEILPHEL----SAARGRLPQVLALLLGFSAMVTL 71
Cdd:pfam02535 249 TTPLGILIGIGVsSIGNSPGADITSGILLAFSAGTFLYVALVELLPHELlrnkSSEKLSLLQLLALLLGFALMALL 324
 
Name Accession Description Interval E-value
Zip pfam02535
ZIP Zinc transporter; The ZIP family consists of zinc transport proteins and many putative ...
 1-71 1.96e-10

ZIP Zinc transporter; The ZIP family consists of zinc transport proteins and many putative metal transporters. The main contribution to this family is from the Arabidopsis thaliana ZIP protein family these proteins are responsible for zinc uptake in the plant. Also found within this family are C. elegans proteins of unknown function which are annotated as being similar to human growth arrest inducible gene product, although this protein in not found within this family.


Pssm-ID: 396884 [Multi-domain]  Cd Length: 325  Bit Score: 54.30  E-value: 1.96e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1011615769   1 MSPLGIVLGMGL-SQSRGPSAALAQCLLQGLAAGTFLYVTFLEILPHEL----SAARGRLPQVLALLLGFSAMVTL 71
Cdd:pfam02535 249 TTPLGILIGIGVsSIGNSPGADITSGILLAFSAGTFLYVALVELLPHELlrnkSSEKLSLLQLLALLLGFALMALL 324
zip TIGR00820
ZIP zinc/iron transport family; The Zinc (Zn2+)-Iron (Fe2+) Permease (ZIP) Family (TC 2.A.5) ...
 2-68 2.50e-03

ZIP zinc/iron transport family; The Zinc (Zn2+)-Iron (Fe2+) Permease (ZIP) Family (TC 2.A.5)Members of the ZIP family consist of proteins with eight putative transmembrane spanners. They are derived from animals, plants and yeast. Theycomprise a diverse family, with several paralogues in any one organism (e.g., at least five in Caenorabditis elegans, at least five in Arabidopsis thaliana and two inSaccharomyces cervisiae. The two S. cerevisiae proteins, Zrt1 and Zrt2, both probably transport Zn2+ with high specificity, but Zrt1 transports Zn2+ with ten-fold higher affinitythan Zrt2. Some members of the ZIP family have been shown to transport Zn2+ while others transport Fe2+, and at least one transports a range of metal ions. The energy source fortransport has not been characterized, but these systems probably function as secondary carriers. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273287  Cd Length: 324  Bit Score: 34.29  E-value: 2.50e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1011615769   2 SPLGIVLGMGLS---QSRGPSAALAQCLLQGLAAGTFLYVTFLEIL------PHELSAARGRLPQVLALLLGFSAM 68
Cdd:TIGR00820 242 TPLGIAIGMGISssyDDSSPTALIVEGVLNAASAGILIYMALVDLLaadfmhPKMQSNLRLQIMAYIALLLGAGLM 317
 
Name Accession Description Interval E-value
Zip pfam02535
ZIP Zinc transporter; The ZIP family consists of zinc transport proteins and many putative ...
 1-71 1.96e-10

ZIP Zinc transporter; The ZIP family consists of zinc transport proteins and many putative metal transporters. The main contribution to this family is from the Arabidopsis thaliana ZIP protein family these proteins are responsible for zinc uptake in the plant. Also found within this family are C. elegans proteins of unknown function which are annotated as being similar to human growth arrest inducible gene product, although this protein in not found within this family.


Pssm-ID: 396884 [Multi-domain]  Cd Length: 325  Bit Score: 54.30  E-value: 1.96e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1011615769   1 MSPLGIVLGMGL-SQSRGPSAALAQCLLQGLAAGTFLYVTFLEILPHEL----SAARGRLPQVLALLLGFSAMVTL 71
Cdd:pfam02535 249 TTPLGILIGIGVsSIGNSPGADITSGILLAFSAGTFLYVALVELLPHELlrnkSSEKLSLLQLLALLLGFALMALL 324
zip TIGR00820
ZIP zinc/iron transport family; The Zinc (Zn2+)-Iron (Fe2+) Permease (ZIP) Family (TC 2.A.5) ...
 2-68 2.50e-03

ZIP zinc/iron transport family; The Zinc (Zn2+)-Iron (Fe2+) Permease (ZIP) Family (TC 2.A.5)Members of the ZIP family consist of proteins with eight putative transmembrane spanners. They are derived from animals, plants and yeast. Theycomprise a diverse family, with several paralogues in any one organism (e.g., at least five in Caenorabditis elegans, at least five in Arabidopsis thaliana and two inSaccharomyces cervisiae. The two S. cerevisiae proteins, Zrt1 and Zrt2, both probably transport Zn2+ with high specificity, but Zrt1 transports Zn2+ with ten-fold higher affinitythan Zrt2. Some members of the ZIP family have been shown to transport Zn2+ while others transport Fe2+, and at least one transports a range of metal ions. The energy source fortransport has not been characterized, but these systems probably function as secondary carriers. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273287  Cd Length: 324  Bit Score: 34.29  E-value: 2.50e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1011615769   2 SPLGIVLGMGLS---QSRGPSAALAQCLLQGLAAGTFLYVTFLEIL------PHELSAARGRLPQVLALLLGFSAM 68
Cdd:TIGR00820 242 TPLGIAIGMGISssyDDSSPTALIVEGVLNAASAGILIYMALVDLLaadfmhPKMQSNLRLQIMAYIALLLGAGLM 317
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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