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Conserved domains on  [gi|62000636|ref|NP_001013781|]
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GAS2-like protein 2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CH_GAS2L1_2 cd21268
calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar ...
 23-163 6.10e-80

calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar proteins; This subfamily includes GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2). They may be involved in the cross-linking of microtubules and microfilaments. Members of this subfamily contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


:

Pssm-ID: 409117  Cd Length: 142  Bit Score: 254.16  E-value: 6.10e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62000636  23 PFKSSEQYLEAMKEDLAEWLRDLYGLDIDADNFLRVLETGLVLCRHANTVTEAALAFLAEAPERAQKIPMPQAGV-FCNG 101
Cdd:cd21268   1 PFKSSEEYLYAMKEDLAEWLNTLYNLDITADNFFEKLETGVLLCKHANNVTRAAREFQAQHPERASPLKLPPREViFYRP 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 62000636 102 AAQPGTFQARDNISNFIQWCRKEMGIQEVLMFETEDLVLRKNVKSVVLCLLELGRRAWRFGV 163
Cdd:cd21268  81 SAKPGSFQARDNVSNFINWCRQLLGIPEVLLFETDDLVLRKNEKNFVLCLLEVARRGAKFGM 142
GAS2 pfam02187
Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members ...
 206-274 7.09e-41

Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members and Gas2 family members. The GAR domain comprises around 57 amino acids and has been shown to bind to microtubules.


:

Pssm-ID: 460480  Cd Length: 69  Bit Score: 143.89  E-value: 7.09e-41
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 62000636   206 LDQMVQSLVSHCTCPVQFSMVKISEGKYRVGDSNTLIFIRILRSHVMVRVGGGWDTLGHYLDKHDPCRC 274
Cdd:pfam02187   1 LDDEVRRIVAQCTCPTKFPVEKVGEGKYRFGDSQKLVFVRILRSHVMVRVGGGWDTLEEYLLKHDPCRA 69
PTZ00449 super family cl33186
104 kDa microneme/rhoptry antigen; Provisional
 278-386 2.04e-05

104 kDa microneme/rhoptry antigen; Provisional


The actual alignment was detected with superfamily member PTZ00449:

Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 48.53  E-value: 2.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62000636  278 SHKPGSFLKPPGPPVQHEVK----VQDGPSQPQPTMTISRSQSPLPPvdwKTYTSSSRKLRPPTPSSPGLRSEPpvraRT 353
Cdd:PTZ00449 551 ETKEGEVGKKPGPAKEHKPSkiptLSKKPEFPKDPKHPKDPEEPKKP---KRPRSAQRPTRPKSPKLPELLDIP----KS 623

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 62000636  354 LREDPLPRSQEKPTPSQRMSSP----GPQFSSTCRGP 386
Cdd:PTZ00449 624 PKRPESPKSPKRPPPPQRPSSPerpeGPKIIKSPKPP 660
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 278-508 1.22e-03

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.85  E-value: 1.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62000636   278 SHKPGSFLKPPGPPVQHEVKVQDGPSQPQPTMTISRSQSPLPPVDWKTYTSSSRKLRPPTPSSPGLRSePPVRARTLRED 357
Cdd:PHA03307  143 SPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRS-SPISASASSPA 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62000636   358 PLP-RSQEKPTPSQRMSSPGPQFSSTCRGPDLQSTLSGKRANRCPGEPPRGRTPtlwvhKEAGSRGTHTKAPTPQRLQIP 436
Cdd:PHA03307  222 PAPgRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGW-----NGPSSRPGPASSSSSPRERSP 296

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 62000636   437 EATSKRTSARGPSPPPRSsslasphmiwVLHQGASPQLSEPMTVhSSSPGKGLTKIPIRLSPARPPTPGRSS 508
Cdd:PHA03307  297 SPSPSSPGSGPAPSSPRA----------SSSSSSSRESSSSSTS-SSSESSRGAAVSPGPSPSRSPSPSRPP 357
 
Name Accession Description Interval E-value
CH_GAS2L1_2 cd21268
calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar ...
 23-163 6.10e-80

calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar proteins; This subfamily includes GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2). They may be involved in the cross-linking of microtubules and microfilaments. Members of this subfamily contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409117  Cd Length: 142  Bit Score: 254.16  E-value: 6.10e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62000636  23 PFKSSEQYLEAMKEDLAEWLRDLYGLDIDADNFLRVLETGLVLCRHANTVTEAALAFLAEAPERAQKIPMPQAGV-FCNG 101
Cdd:cd21268   1 PFKSSEEYLYAMKEDLAEWLNTLYNLDITADNFFEKLETGVLLCKHANNVTRAAREFQAQHPERASPLKLPPREViFYRP 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 62000636 102 AAQPGTFQARDNISNFIQWCRKEMGIQEVLMFETEDLVLRKNVKSVVLCLLELGRRAWRFGV 163
Cdd:cd21268  81 SAKPGSFQARDNVSNFINWCRQLLGIPEVLLFETDDLVLRKNEKNFVLCLLEVARRGAKFGM 142
GAS2 pfam02187
Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members ...
 206-274 7.09e-41

Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members and Gas2 family members. The GAR domain comprises around 57 amino acids and has been shown to bind to microtubules.


Pssm-ID: 460480  Cd Length: 69  Bit Score: 143.89  E-value: 7.09e-41
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 62000636   206 LDQMVQSLVSHCTCPVQFSMVKISEGKYRVGDSNTLIFIRILRSHVMVRVGGGWDTLGHYLDKHDPCRC 274
Cdd:pfam02187   1 LDDEVRRIVAQCTCPTKFPVEKVGEGKYRFGDSQKLVFVRILRSHVMVRVGGGWDTLEEYLLKHDPCRA 69
GAS2 smart00243
Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain
 205-276 7.88e-33

Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain


Pssm-ID: 128539  Cd Length: 73  Bit Score: 121.40  E-value: 7.88e-33
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 62000636    205 NLDQMVQSLVSHCTCPVQFSMVKISEGKYRVGDSNTLIFIRILRSHVMVRVGGGWDTLGHYLDKHDPCRCTS 276
Cdd:smart00243   2 KIDDEVKRIVEDCKCPTKFQVEKISEGKYRFGDSQILRLVRILRSTVMVRVGGGWETLDEYLLKHDPCRAKG 73
CH pfam00307
Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal ...
 32-158 1.44e-12

Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.


Pssm-ID: 425596 [Multi-domain]  Cd Length: 109  Bit Score: 64.62  E-value: 1.44e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62000636    32 EAMKEDLAEWLRDLYGLDIDA---DNFLRVLETGLVLCRHANTVteaalaflaeapeRAQKIPMPQAgvfcngaaQPGTF 108
Cdd:pfam00307   1 LELEKELLRWINSHLAEYGPGvrvTNFTTDLRDGLALCALLNKL-------------APGLVDKKKL--------NKSEF 59

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 62000636   109 QARDNISNFIQWCRKEMGIQEVLMfETEDLVLRKNvKSVVLCLLELGRRA 158
Cdd:pfam00307  60 DKLENINLALDVAEKKLGVPKVLI-EPEDLVEGDN-KSVLTYLASLFRRF 107
CH smart00033
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ...
 36-154 2.70e-09

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.


Pssm-ID: 214479 [Multi-domain]  Cd Length: 101  Bit Score: 55.01  E-value: 2.70e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62000636     36 EDLAEWLRDLYGLDI--DADNFLRVLETGLVLCRHANTVteaalaflaeapeRAQKIPMPQAgvfcngAAQPGTFQARDN 113
Cdd:smart00033   1 KTLLRWVNSLLAEYDkpPVTNFSSDLKDGVALCALLNSL-------------SPGLVDKKKV------AASLSRFKKIEN 61

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 62000636    114 ISNFIQWCRKEMGIqeVLMFETEDLVL-RKNVKSVVLCLLEL 154
Cdd:smart00033  62 INLALSFAEKLGGK--VVLFEPEDLVEgPKLILGVIWTLISL 101
SCP1 COG5199
Calponin [Cytoskeleton];
32-158 7.17e-06

Calponin [Cytoskeleton];


Pssm-ID: 227526 [Multi-domain]  Cd Length: 178  Bit Score: 47.22  E-value: 7.17e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62000636  32 EAMKEdLAEWLRDLYGLDIDAD-NFLRVLETGLVLCRHANTVTEAALaflaeapeRAQKIPMPqagvfcngaaqpgtFQA 110
Cdd:COG5199  13 KQQKE-VTLWIETVLGEKFEPPgDLLSLLKDGVRLCRILNEASPLDI--------KYKESKMP--------------FVQ 69

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 62000636 111 RDNISNFIQWCRKeMGIQEVLMFETEDLVLRKNVKSVVLCLLELGRRA 158
Cdd:COG5199  70 MENISSFINGLKK-LRVPEYELFQTNDLFEAKDLRQVVICLYSLSRYA 116
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 278-386 2.04e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 48.53  E-value: 2.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62000636  278 SHKPGSFLKPPGPPVQHEVK----VQDGPSQPQPTMTISRSQSPLPPvdwKTYTSSSRKLRPPTPSSPGLRSEPpvraRT 353
Cdd:PTZ00449 551 ETKEGEVGKKPGPAKEHKPSkiptLSKKPEFPKDPKHPKDPEEPKKP---KRPRSAQRPTRPKSPKLPELLDIP----KS 623

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 62000636  354 LREDPLPRSQEKPTPSQRMSSP----GPQFSSTCRGP 386
Cdd:PTZ00449 624 PKRPESPKSPKRPPPPQRPSSPerpeGPKIIKSPKPP 660
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 271-378 1.71e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 45.53  E-value: 1.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62000636   271 PCRCTSLSHKPGSFLKPPGPPVQHevKVQDGPSQ------PQP---TMTISRSQSPLPPVDWKTYTSSSRKLRPPTPSSP 341
Cdd:pfam03154 257 PPSQVSPQPLPQPSLHGQMPPMPH--SLQTGPSHmqhpvpPQPfplTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQL 334

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 62000636   342 glRSEPPVRARTLREDPLPRSQEKPTPSQRMSS-PGPQ 378
Cdd:pfam03154 335 --QSQQPPREQPLPPAPLSMPHIKPPPTTPIPQlPNPQ 370
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 278-508 1.22e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.85  E-value: 1.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62000636   278 SHKPGSFLKPPGPPVQHEVKVQDGPSQPQPTMTISRSQSPLPPVDWKTYTSSSRKLRPPTPSSPGLRSePPVRARTLRED 357
Cdd:PHA03307  143 SPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRS-SPISASASSPA 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62000636   358 PLP-RSQEKPTPSQRMSSPGPQFSSTCRGPDLQSTLSGKRANRCPGEPPRGRTPtlwvhKEAGSRGTHTKAPTPQRLQIP 436
Cdd:PHA03307  222 PAPgRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGW-----NGPSSRPGPASSSSSPRERSP 296

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 62000636   437 EATSKRTSARGPSPPPRSsslasphmiwVLHQGASPQLSEPMTVhSSSPGKGLTKIPIRLSPARPPTPGRSS 508
Cdd:PHA03307  297 SPSPSSPGSGPAPSSPRA----------SSSSSSSRESSSSSTS-SSSESSRGAAVSPGPSPSRSPSPSRPP 357
 
Name Accession Description Interval E-value
CH_GAS2L1_2 cd21268
calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar ...
 23-163 6.10e-80

calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar proteins; This subfamily includes GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2). They may be involved in the cross-linking of microtubules and microfilaments. Members of this subfamily contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409117  Cd Length: 142  Bit Score: 254.16  E-value: 6.10e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62000636  23 PFKSSEQYLEAMKEDLAEWLRDLYGLDIDADNFLRVLETGLVLCRHANTVTEAALAFLAEAPERAQKIPMPQAGV-FCNG 101
Cdd:cd21268   1 PFKSSEEYLYAMKEDLAEWLNTLYNLDITADNFFEKLETGVLLCKHANNVTRAAREFQAQHPERASPLKLPPREViFYRP 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 62000636 102 AAQPGTFQARDNISNFIQWCRKEMGIQEVLMFETEDLVLRKNVKSVVLCLLELGRRAWRFGV 163
Cdd:cd21268  81 SAKPGSFQARDNVSNFINWCRQLLGIPEVLLFETDDLVLRKNEKNFVLCLLEVARRGAKFGM 142
CH_GAS2-like cd21204
calponin homology (CH) domain found in the growth arrest-specific protein 2 family; The growth ...
 28-162 2.07e-51

calponin homology (CH) domain found in the growth arrest-specific protein 2 family; The growth arrest-specific protein 2 (GAS-2) family includes GAS-2, and GAS-2 like proteins, GAS2L1-3. GAS-2 may play a role in apoptosis by acting as a cell death substrate for caspases. GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2) may be involved in the cross-linking of microtubules and microfilaments. GAS2L3, also called GAS2-like protein 3, is a cytoskeletal linker protein that may promote and stabilize the formation of the actin and microtubule network. Members of this family contain a single copy of the CH domain at the N-terminal region. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409053  Cd Length: 131  Bit Score: 175.92  E-value: 2.07e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62000636  28 EQYLEAMKEDLAEWLRDLYGLDIDADNFLRVLETGLVLCRHANTVTeaaLAFLAEAPERAQKIPMPQAGVFCNGAAQPGT 107
Cdd:cd21204   1 EEALLPMKEDLAEWLNDLLGDDLTPDNFLDELRNGVVLCQLAQKIQ---EAAEKAREAGKKNGPPPSYKLKCNENAKPGS 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 62000636 108 FQARDNISNFIQWCRKEmGIQEVLMFETEDLVLRKNVKSVVLCLLELGRRAWRFG 162
Cdd:cd21204  78 FFARDNVANFLRWCRKL-GVDEVLLFESEDLVLHKNPRQVLLCLLELARIAARYG 131
GAS2 pfam02187
Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members ...
 206-274 7.09e-41

Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members and Gas2 family members. The GAR domain comprises around 57 amino acids and has been shown to bind to microtubules.


Pssm-ID: 460480  Cd Length: 69  Bit Score: 143.89  E-value: 7.09e-41
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 62000636   206 LDQMVQSLVSHCTCPVQFSMVKISEGKYRVGDSNTLIFIRILRSHVMVRVGGGWDTLGHYLDKHDPCRC 274
Cdd:pfam02187   1 LDDEVRRIVAQCTCPTKFPVEKVGEGKYRFGDSQKLVFVRILRSHVMVRVGGGWDTLEEYLLKHDPCRA 69
GAS2 smart00243
Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain
 205-276 7.88e-33

Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain


Pssm-ID: 128539  Cd Length: 73  Bit Score: 121.40  E-value: 7.88e-33
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 62000636    205 NLDQMVQSLVSHCTCPVQFSMVKISEGKYRVGDSNTLIFIRILRSHVMVRVGGGWDTLGHYLDKHDPCRCTS 276
Cdd:smart00243   2 KIDDEVKRIVEDCKCPTKFQVEKISEGKYRFGDSQILRLVRILRSTVMVRVGGGWETLDEYLLKHDPCRAKG 73
CH_GAS2 cd21267
calponin homology (CH) domain found in growth arrest-specific protein 2; Growth ...
 28-163 9.41e-31

calponin homology (CH) domain found in growth arrest-specific protein 2; Growth arrest-specific protein 2 (GAS-2) may play a role in apoptosis by acting as a cell death substrate for caspases. It contains a single copy of the CH domain at the N-terminal region. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409116  Cd Length: 136  Bit Score: 117.73  E-value: 9.41e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62000636  28 EQYLEAMKEDLAEWLRDLYGLDIDADNFLRVLETGLVLCRHANTVTEAALAFLAEAPERAQKIPMPQagVFCNGAAQPGT 107
Cdd:cd21267   2 EASLLPMKEDLALWLTNLLGKEITAESFMEKLDNGALLCQLAETLQEKFKENSADANKPGKSLPVRK--IPCRANAPSGS 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 62000636 108 FQARDNISNFIQWCRkEMGIQEVLMFETEDLVLRKNVKSVVLCLLELGRRAWRFGV 163
Cdd:cd21267  80 FFARDNTANFLSWCR-DVGVGDTCLFESEGLVLHKQPREVCLCLLELGRIAARFGV 134
CH_GAS2L3 cd21269
calponin homology (CH) domain found in growth arrest-specific protein 2-like 3; Growth ...
 28-162 4.25e-27

calponin homology (CH) domain found in growth arrest-specific protein 2-like 3; Growth arrest-specific protein 2-like 3 (GAS2L3), also called GAS2-like protein 3, is a cytoskeletal linker protein that may promote and stabilize the formation of the actin and microtubule network. It contains a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409118  Cd Length: 130  Bit Score: 106.85  E-value: 4.25e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62000636  28 EQYLEAMKEDLAEWLRDLYGLDIDADNFLRVLETGLVLCRHANTVTEAALAFLAEAPERaqkiPMPQAGVFCNGAAQPGT 107
Cdd:cd21269   1 EATLVPMQEDLSIWLSGMLGKEVKAERFMEELDNGVLLCQLIGVLQSKIKECCSTEELK----HFPMRKVPCKKDAPSGS 76

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 62000636 108 FQARDNISNFIQWCRkEMGIQEVLMFETEDLVLRKNVKSVVLCLLELGRRAWRFG 162
Cdd:cd21269  77 FFARDNTANFLSWCR-AIGVDETYLFESEGLVLHKDPRQVCLCLLEIGRIVSRYG 130
CH_SF cd00014
calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding ...
 35-156 3.86e-14

calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding motifs, which may be present as a single copy or in tandem repeats (which increase binding affinity). They either function as autonomous actin binding motifs or serve a regulatory function. CH domains are found in cytoskeletal and signal transduction proteins, including actin-binding proteins like spectrin, alpha-actinin, dystrophin, utrophin, and fimbrin, as well as proteins essential for regulation of cell shape (cortexillins), and signaling proteins (Vav).


Pssm-ID: 409031 [Multi-domain]  Cd Length: 103  Bit Score: 68.90  E-value: 3.86e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62000636  35 KEDLAEWLRDLYG--LDIDADNFLRVLETGLVLCRHANTVTEAALaflaeaPERAQKIPMPqagvfcngaaqpgtFQARD 112
Cdd:cd00014   1 EEELLKWINEVLGeeLPVSITDLFESLRDGVLLCKLINKLSPGSI------PKINKKPKSP--------------FKKRE 60

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 62000636 113 NISNFIQWCRKeMGIQEVLMFETEDLVLRKNVKSVVLCLLELGR 156
Cdd:cd00014  61 NINLFLNACKK-LGLPELDLFEPEDLYEKGNLKKVLGTLWALAL 103
CH pfam00307
Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal ...
 32-158 1.44e-12

Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.


Pssm-ID: 425596 [Multi-domain]  Cd Length: 109  Bit Score: 64.62  E-value: 1.44e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62000636    32 EAMKEDLAEWLRDLYGLDIDA---DNFLRVLETGLVLCRHANTVteaalaflaeapeRAQKIPMPQAgvfcngaaQPGTF 108
Cdd:pfam00307   1 LELEKELLRWINSHLAEYGPGvrvTNFTTDLRDGLALCALLNKL-------------APGLVDKKKL--------NKSEF 59

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 62000636   109 QARDNISNFIQWCRKEMGIQEVLMfETEDLVLRKNvKSVVLCLLELGRRA 158
Cdd:pfam00307  60 DKLENINLALDVAEKKLGVPKVLI-EPEDLVEGDN-KSVLTYLASLFRRF 107
CH_SCP1-like cd21210
calponin homology (CH) domain found in Saccharomyces cerevisiae transgelin (SCP1) and similar ...
 34-156 1.80e-11

calponin homology (CH) domain found in Saccharomyces cerevisiae transgelin (SCP1) and similar proteins; The family includes transgelins from Saccharomyces cerevisiae and Schizosaccharomyces pombe, which are also called SCP1 and STG1, respectively. Transgelin, also called calponin homolog 1, has actin-binding and actin-bundling activity. It stabilizes actin filaments against disassembly. Transgelin contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409059 [Multi-domain]  Cd Length: 101  Bit Score: 61.23  E-value: 1.80e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62000636  34 MKEDLAEWLRDLYGLDIDADNFLRVLETGLVLCRHANTVTEAALAflaeapeRAQKIPMPqagvfcngaaqpgtFQARDN 113
Cdd:cd21210   1 AEQEAREWIEEVLGEKLAQGDLLDALKDGVVLCKLANRILPADIR-------KYKESKMP--------------FVQMEN 59

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 62000636 114 ISNFIQWCRKeMGIQEVLMFETEDLVLRKNVKSVVLCLLELGR 156
Cdd:cd21210  60 ISAFLNAARK-LGVPENDLFQTVDLFERKNPAQVLQCLHALSR 101
CH_dMP20-like cd21207
calponin homology (CH) domain found in Drosophila melanogaster muscle-specific protein 20 ...
 40-156 4.60e-10

calponin homology (CH) domain found in Drosophila melanogaster muscle-specific protein 20 (dMP20) and similar domains; This subfamily contains Drosophila melanogaster muscle-specific protein 20 (dMP20), Echinococcus granulosus myophilin, Dictyostelium discoideum Rac guanine nucleotide exchange factor B (also called Trix), and similar proteins. dMP20 is present only in the synchronous muscles of D. melanogaster. It may be involved in the system linking the nerve impulse with the contraction or the relaxation process. Trix is involved in the regulation of the late steps of the endocytic pathway. dMP20 contains a single copy of the CH domain, while Trix (triple CH-domain array exchange factor) contains three, two type 3 CH domains which are included in this model, and one type 1 CH domain that is not included in this subfamily, but is part of the superfamily. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409056 [Multi-domain]  Cd Length: 107  Bit Score: 57.71  E-value: 4.60e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62000636  40 EWLRDLYGLDIDAD-NFLRVLETGLVLCRHANTVteaalaflaeAPERAQKIpmpqagvfcNGAAQPgtFQARDNISNFI 118
Cdd:cd21207  12 DWIEAVTGEKLDDGkDYEDVLKDGVILCKLINIL----------KPGSVKKI---------NTSKMA--FKLMENIENFL 70

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 62000636 119 QWCrKEMGIQEVLMFETEDLVLRKNVKSVVLCLLELGR 156
Cdd:cd21207  71 TAC-KGYGVPKTDLFQTVDLYEKKNIPQVTNCLFALGR 107
CH smart00033
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ...
 36-154 2.70e-09

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.


Pssm-ID: 214479 [Multi-domain]  Cd Length: 101  Bit Score: 55.01  E-value: 2.70e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62000636     36 EDLAEWLRDLYGLDI--DADNFLRVLETGLVLCRHANTVteaalaflaeapeRAQKIPMPQAgvfcngAAQPGTFQARDN 113
Cdd:smart00033   1 KTLLRWVNSLLAEYDkpPVTNFSSDLKDGVALCALLNSL-------------SPGLVDKKKV------AASLSRFKKIEN 61

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 62000636    114 ISNFIQWCRKEMGIqeVLMFETEDLVL-RKNVKSVVLCLLEL 154
Cdd:smart00033  62 INLALSFAEKLGGK--VVLFEPEDLVEgPKLILGVIWTLISL 101
SCP1 COG5199
Calponin [Cytoskeleton];
32-158 7.17e-06

Calponin [Cytoskeleton];


Pssm-ID: 227526 [Multi-domain]  Cd Length: 178  Bit Score: 47.22  E-value: 7.17e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62000636  32 EAMKEdLAEWLRDLYGLDIDAD-NFLRVLETGLVLCRHANTVTEAALaflaeapeRAQKIPMPqagvfcngaaqpgtFQA 110
Cdd:COG5199  13 KQQKE-VTLWIETVLGEKFEPPgDLLSLLKDGVRLCRILNEASPLDI--------KYKESKMP--------------FVQ 69

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 62000636 111 RDNISNFIQWCRKeMGIQEVLMFETEDLVLRKNVKSVVLCLLELGRRA 158
Cdd:COG5199  70 MENISSFINGLKK-LRVPEYELFQTNDLFEAKDLRQVVICLYSLSRYA 116
CH_AtKIN14-like cd21203
calponin homology (CH) domain found in Arabidopsis thaliana Kinesin-like KIN-14 protein family; ...
 35-154 9.93e-06

calponin homology (CH) domain found in Arabidopsis thaliana Kinesin-like KIN-14 protein family; Kinesins are microtubule-dependent molecular motors that play important roles in intracellular transport and in cell division. This family includes a group of kinesin-like proteins belonging to KIN-14 protein family. They all contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409052 [Multi-domain]  Cd Length: 112  Bit Score: 45.48  E-value: 9.93e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62000636  35 KEDLAEWLRDLYGLDIDAD----NFLRVLETGLVLCRHANTVteaalaflaeAPERAQKIpmPQAGVFCNGAAQpGTFQA 110
Cdd:cd21203   2 RYEAAEWIQNVLGVLVLPDpseeEFRLCLRDGVVLCKLLNKL----------QPGAVPKV--VESPDDPDGAAG-SAFQY 68

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 62000636 111 RDNISNFIQWCrKEMGIQevlMFETEDL--VLRKNVKSVVLCLLEL 154
Cdd:cd21203  69 FENVRNFLVAI-EEMGLP---TFEASDLeqGGGGSRPRVVDCILAL 110
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 278-386 2.04e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 48.53  E-value: 2.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62000636  278 SHKPGSFLKPPGPPVQHEVK----VQDGPSQPQPTMTISRSQSPLPPvdwKTYTSSSRKLRPPTPSSPGLRSEPpvraRT 353
Cdd:PTZ00449 551 ETKEGEVGKKPGPAKEHKPSkiptLSKKPEFPKDPKHPKDPEEPKKP---KRPRSAQRPTRPKSPKLPELLDIP----KS 623

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 62000636  354 LREDPLPRSQEKPTPSQRMSSP----GPQFSSTCRGP 386
Cdd:PTZ00449 624 PKRPESPKSPKRPPPPQRPSSPerpeGPKIIKSPKPP 660
CH_IQGAP cd21206
calponin homology (CH) domain found in the IQ motif containing GTPase activating protein ...
 112-151 6.15e-05

calponin homology (CH) domain found in the IQ motif containing GTPase activating protein family; Members of the IQ motif containing GTPase activating protein (IQGAP) family are associated with the Ras GTP-binding protein and act as essential regulators of cytoskeletal function. There are three known IQGAP family members: IQGAP1, IQGAP2, and IQGAP3. They are multi-domain molecules having a calponin-homology (CH) domain which binds F-actin, IQGAP-specific repeats, a single WW domain, four IQ motifs that mediate interactions with calmodulin, and a RasGAP related domain that binds active Rho family GTPases. IQGAP1 negatively regulates Ras family GTPases by stimulating their intrinsic GTPase activity. It lacks GAP activity. Both IQGAP1 and IQGAP2 specifically bind to Cdc42 and Rac1, but not to RhoA. Despite similarities to part of the sequence of RasGAP, neither IQGAP1 nor IQGAP2 interacts with Ras. IQGAP3 regulates the organization of the cytoskeleton under the regulation of Rac1 and Cdc42 in neuronal cells. The depletion of IQGAP3 is shown to impair neurite or axon outgrowth in neuronal cells with disorganized cytoskeleton.


Pssm-ID: 409055 [Multi-domain]  Cd Length: 118  Bit Score: 43.37  E-value: 6.15e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 62000636 112 DNISNFIQWCrKEMGIQEVLMFETEDLVLRKNVKSVVLCL 151
Cdd:cd21206  69 DNINHFLRAL-KKIGLPKIFHFETTDLYEKKNIPKVIYCL 107
CH_LMO7-like cd21208
calponin homology (CH) domain found in LIM domain only protein 7 and similar proteins; This ...
 41-159 8.62e-05

calponin homology (CH) domain found in LIM domain only protein 7 and similar proteins; This family includes LIM domain only protein 7 (LMO-7) and LIM and calponin homology domains-containing protein 1 (LIMCH1), and similar proteins. LMO-7, also called F-box only protein 20, or LOMP, is a transcription regulator for expression of many Emery-Dreifuss muscular dystrophy (EDMD)-relevant genes. It binds to alpha-actinin and AF6/afadin at adherens junctions for epithelial cell-cell adhesion. LIMCH1 acts as an actin stress fiber-associated protein that activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. It positively regulates actin stress fiber assembly and stabilizes focal adhesions, and therefore negatively regulates cell spreading and cell migration. Members of this family contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409057 [Multi-domain]  Cd Length: 119  Bit Score: 42.71  E-value: 8.62e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62000636  41 WLRDLYGLDIDADNFLRVLETGLVLCRHANTVteaalaflaeAPERAQKIPMPqagvfcngaaqPGTFQARDNISNFIQW 120
Cdd:cd21208   8 WIEAVTGKKFPSDDFRESLEDGILLCELINAI----------KPGSIKKINRL-----------PTPIAGLDNLNLFLKA 66

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 62000636 121 CRkEMGIQEVLMFETEDLV---------------LRKNVKSVVLCLLELGRRAW 159
Cdd:cd21208  67 CE-DLGLKDSQLFDPTDLQdlsnrriathvrkkeDERRLKNVAITLYWLGRAAR 119
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 271-378 1.71e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 45.53  E-value: 1.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62000636   271 PCRCTSLSHKPGSFLKPPGPPVQHevKVQDGPSQ------PQP---TMTISRSQSPLPPVDWKTYTSSSRKLRPPTPSSP 341
Cdd:pfam03154 257 PPSQVSPQPLPQPSLHGQMPPMPH--SLQTGPSHmqhpvpPQPfplTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQL 334

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 62000636   342 glRSEPPVRARTLREDPLPRSQEKPTPSQRMSS-PGPQ 378
Cdd:pfam03154 335 --QSQQPPREQPLPPAPLSMPHIKPPPTTPIPQlPNPQ 370
CH_VAV cd21201
calponin homology (CH) domain found in VAV proteins; VAV proteins function both as cytoplasmic ...
 39-154 5.00e-04

calponin homology (CH) domain found in VAV proteins; VAV proteins function both as cytoplasmic guanine nucleotide exchange factors (GEFs) for Rho GTPases and as scaffold proteins, and they play important roles in cell signaling by coupling cell surface receptors to various effector functions. They play key roles in processes that require cytoskeletal reorganization including immune synapse formation, phagocytosis, cell spreading, and platelet aggregation, among others. Vertebrates have three VAV proteins (VAV1, VAV2, and VAV3). VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. This model corresponds to the CH domain, an actin-binding domain which is present as a single copy in VAV proteins.


Pssm-ID: 409050  Cd Length: 117  Bit Score: 40.70  E-value: 5.00e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62000636  39 AEWLRDLYGL--DIDADN-------FLRVLETGLVLCRHANTVteaalaflaeapeRAQKIPMPQagvFCNgAAQPGTFQ 109
Cdd:cd21201   7 ADWLIRCGVLppDHRATQpnatvfdLAQALRDGVLLCQLLNRL-------------SPGSVDDRE---INL-RPQMSQFL 69

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 62000636 110 ARDNISNFIQWCRKEMGIQEVLMFETEDLVLRKNVKSVVLCLLEL 154
Cdd:cd21201  70 CLKNIRTFLQACRTVFGLRSADLFEPEDLYDVTNFGKVIRTLSKL 114
CH_CNN1 cd21282
calponin homology (CH) domain found in calponin-1 and similar proteins; Calponin-1 (CNN1), ...
 35-158 1.19e-03

calponin homology (CH) domain found in calponin-1 and similar proteins; Calponin-1 (CNN1), also called basic calponin, or smooth muscle calponin H1, is a thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C, and tropomyosin. Calponin-1 contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409131 [Multi-domain]  Cd Length: 108  Bit Score: 39.47  E-value: 1.19e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62000636  35 KEDLAEWLRDLYGLDIdADNFLRVLETGLVLCRHANTVteaalaflaeAPERAQKIpmpqagvfcNGAAQpgTFQARDNI 114
Cdd:cd21282   5 EEELRVWIEGVTGRRI-GDNFMDGLKDGVILCELINKL----------QPGSVRKI---------NESTQ--NWHKLENI 62

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 62000636 115 SNFIQwCRKEMGIQEVLMFETEDLVLRKNVKSVVLCLLELGRRA 158
Cdd:cd21282  63 GNFIK-AIMHYGVKPHDIFEANDLFENTNHTQVQSTLIALASMA 105
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 278-508 1.22e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.85  E-value: 1.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62000636   278 SHKPGSFLKPPGPPVQHEVKVQDGPSQPQPTMTISRSQSPLPPVDWKTYTSSSRKLRPPTPSSPGLRSePPVRARTLRED 357
Cdd:PHA03307  143 SPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRS-SPISASASSPA 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62000636   358 PLP-RSQEKPTPSQRMSSPGPQFSSTCRGPDLQSTLSGKRANRCPGEPPRGRTPtlwvhKEAGSRGTHTKAPTPQRLQIP 436
Cdd:PHA03307  222 PAPgRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGW-----NGPSSRPGPASSSSSPRERSP 296

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 62000636   437 EATSKRTSARGPSPPPRSsslasphmiwVLHQGASPQLSEPMTVhSSSPGKGLTKIPIRLSPARPPTPGRSS 508
Cdd:PHA03307  297 SPSPSSPGSGPAPSSPRA----------SSSSSSSRESSSSSTS-SSSESSRGAAVSPGPSPSRSPSPSRPP 357
CH_LMO7 cd21277
calponin homology (CH) domain found in LIM domain only protein 7; LIM domain only protein 7 ...
 41-158 2.22e-03

calponin homology (CH) domain found in LIM domain only protein 7; LIM domain only protein 7 (LMO-7), also called F-box only protein 20, or LOMP, is a transcription regulator for expression of many Emery-Dreifuss muscular dystrophy (EDMD)-relevant genes. It binds to alpha-actinin and AF6/afadin at adherens junctions for epithelial cell-cell adhesion. It contains a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409126 [Multi-domain]  Cd Length: 116  Bit Score: 38.66  E-value: 2.22e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62000636  41 WLRDLYGLDIDADNFLRVLETGLVLCRHANTVTEAALaflaeapERAQKIPMPQAGVfcngaaqpgtfqarDNISNFIQW 120
Cdd:cd21277   8 WIEAVTGKNFGNKDFRSALENGVLLCDLINKIKPGII-------KKINRLSTPIAGL--------------DNINVFLKA 66

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 62000636 121 CrKEMGIQEVLMF---ETEDLVLR---------KNVKSVVLCLLELGRRA 158
Cdd:cd21277  67 C-EKLGLKEAQLFhpgDLQDLSTRvtvkqeetdRRLKNVLITLYWLGRKA 115
CH_CNN2 cd21283
calponin homology (CH) domain found in calponin-2; Calponin-2 (CNN2), also called neutral ...
 35-158 2.39e-03

calponin homology (CH) domain found in calponin-2; Calponin-2 (CNN2), also called neutral calponin, or smooth muscle calponin H2, is an actin cytoskeleton-associated regulatory protein that inhibits the activity of myosin-ATPase and cytoskeleton dynamics. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409132 [Multi-domain]  Cd Length: 109  Bit Score: 38.37  E-value: 2.39e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62000636  35 KEDLAEWLRDLYGLDIdADNFLRVLETGLVLCRHANTVteaalaflaeAPERAQKIpmpqagvfcNGAAQpgTFQARDNI 114
Cdd:cd21283   5 EAELRTWIEGLTGRSI-GPDFQKGLKDGVILCELMNKL----------QPGSVPKI---------NRSMQ--NWHQLENL 62

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 62000636 115 SNFIqwcrKEM---GIQEVLMFETEDLVLRKNVKSVVLCLLELGRRA 158
Cdd:cd21283  63 SNFI----KAMvsyGMKPVDLFEANDLFESGNMTQVQVSLLALAGMA 105
CH_CNN3 cd21284
calponin homology (CH) domain found in calponin-3; Calponin-3 (CNN3), also called acidic ...
 29-158 6.01e-03

calponin homology (CH) domain found in calponin-3; Calponin-3 (CNN3), also called acidic isoform calponin, is an F-actin-binding protein that is expressed in the brain and has been shown to control dendritic spine morphology, density, and plasticity by regulating actin cytoskeletal reorganization and dynamics. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409133 [Multi-domain]  Cd Length: 111  Bit Score: 37.19  E-value: 6.01e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62000636  29 QYLEAMKEDLAEWLRDLYGLDIdADNFLRVLETGLVLCRHANTVteaalaflaeAPERAQKIpmpqagvfcNGAAQpgTF 108
Cdd:cd21284   1 KYDPQKEEELRNWIEEVTGMSI-GENFQKGLKDGVILCELINKL----------QPGSIRKI---------NESKL--NW 58

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 62000636 109 QARDNISNFIQwCRKEMGIQEVLMFETEDLVLRKNVKSVVLCLLELGRRA 158
Cdd:cd21284  59 HQLENIGNFIK-AIQAYGMKPHDIFEANDLFENGNMTQVQTTLLALAGLA 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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