NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|62078733|ref|NP_001014024|]
View 

protein MAK16 homolog [Rattus norvegicus]

Protein Classification

MAK16 family protein( domain architecture ID 11476335)

MAK16 family protein, such as SmMak16, the Schistosoma mansoni homolog of MAK16 from yeast, which targets protein transport to the nucleolus and human MAK16 homolog

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PLN00040 PLN00040
Protein MAK16 homolog; Provisional
 1-194 7.06e-90

Protein MAK16 homolog; Provisional


:

Pssm-ID: 215038 [Multi-domain]  Cd Length: 233  Bit Score: 267.02  E-value: 7.06e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078733    1 MQSDDVIWNtLGNKQFCSYKIRTKTQGFCRNEYSLTGLCNRSSCPLANSQYATIKEEKGQCYLYMKVIERAAFPRRLWER 80
Cdd:PLN00040   1 MQHDEVIWQ-VINHNHCSFKAKIDTGNFCRNKYNVTGLCNRSSCPLANSRYATIREEDGRFYLYMKTIERAHMPNKLWEK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078733   81 VRLNKNYEKALEQIDENLIYWPRFIRHKCKQRFTKITQYLIRIRKLTLKRRKKLVPLSKKVERREKRREEKALIAAQLDN 160
Cdd:PLN00040  80 VKLSRNYEKALEQIDKHLAYWPKFLVHKNKQRLTKMTQYLIRMRKLALKTREKIVTTPRKLLKRERRRESKAQKAAQLEK 159

                        170       180       190
                 ....*....|....*....|....*....|....
gi 62078733  161 AIEKELLERLKQDTYGDIYNFPIHAFDKALEKQE 194
Cdd:PLN00040 160 SIEKELLERLKSGTYGDIYNFPSKSYNKVLEMEE 193
 
Name Accession Description Interval E-value
PLN00040 PLN00040
Protein MAK16 homolog; Provisional
 1-194 7.06e-90

Protein MAK16 homolog; Provisional


Pssm-ID: 215038 [Multi-domain]  Cd Length: 233  Bit Score: 267.02  E-value: 7.06e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078733    1 MQSDDVIWNtLGNKQFCSYKIRTKTQGFCRNEYSLTGLCNRSSCPLANSQYATIKEEKGQCYLYMKVIERAAFPRRLWER 80
Cdd:PLN00040   1 MQHDEVIWQ-VINHNHCSFKAKIDTGNFCRNKYNVTGLCNRSSCPLANSRYATIREEDGRFYLYMKTIERAHMPNKLWEK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078733   81 VRLNKNYEKALEQIDENLIYWPRFIRHKCKQRFTKITQYLIRIRKLTLKRRKKLVPLSKKVERREKRREEKALIAAQLDN 160
Cdd:PLN00040  80 VKLSRNYEKALEQIDKHLAYWPKFLVHKNKQRLTKMTQYLIRMRKLALKTREKIVTTPRKLLKRERRRESKAQKAAQLEK 159

                        170       180       190
                 ....*....|....*....|....*....|....
gi 62078733  161 AIEKELLERLKQDTYGDIYNFPIHAFDKALEKQE 194
Cdd:PLN00040 160 SIEKELLERLKSGTYGDIYNFPSKSYNKVLEMEE 193
MAK16 COG5129
Nuclear protein with HMG-like acidic region [General function prediction only];
2-285 2.25e-70

Nuclear protein with HMG-like acidic region [General function prediction only];


Pssm-ID: 227458 [Multi-domain]  Cd Length: 303  Bit Score: 219.92  E-value: 2.25e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078733   2 QSDDVIWNTLGnKQFCSYKIRTKTQGFCRNEYSLTGLCNRSSCPLANSQYATIKEEKGQCYLYMKVIERAAFPRRLWERV 81
Cdd:COG5129   1 MSDESLWQVSG-ENFCSFRIKTEEQNFCRNEYNVTGLCDRQSCPLANSRYATVRADNGKLYLYMKTPERAHVPRKLWERI 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078733  82 RLNKNYEKALEQIDENLIYWPRFIRHKCKQRFTKITQYLIRIRKLTLKRR-KKLVPLSKKVERREKRREEKALIAAQLDN 160
Cdd:COG5129  80 KLSKNYEKALKQIDESLLFWDEKVIHKCKQRLTKLTQYLLKARRLALFKEhGEYMVRKPKMNRREKLRERKALNAAKFEK 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078733 161 AIEKELLERLKQDTYGDI-YNFPIHAFDKALEKQEAESDSEDEEDEEEDEEEDVgKREFVEDDEVEESDLSDFEDMDKLN 239
Cdd:COG5129 160 NIEKELMLRLKSGIYGDTpLNVREHLWNKAATEREKRQDEKERYVEEEEESDTE-LEAVTDDSEKEKTKKKDLEKWLGSD 238

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 62078733 240 TDSEEDDESSREEEAHKAKHKGKAPLKGPLRK---------KRAYVEIEYEQETE 285
Cdd:COG5129 239 QSMETSESEEEESSESESDEDEDEDNKGKIRKrktddakksRKPHIHIEYEQERE 293
Ribosomal_L28e pfam01778
Ribosomal L28e protein family;
6-119 6.82e-45

Ribosomal L28e protein family;


Pssm-ID: 460323  Cd Length: 115  Bit Score: 148.05  E-value: 6.82e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078733     6 VIWNTLGNKQfcSYKIRTKT---QGFCRNEYSLTGLCNRSSCPLANSQYATIKEEKGQCYLYMKVIERAAFPRRLWERVR 82
Cdd:pfam01778   1 LIWEIIRNNN--SFLVKTRTgngQTFSREPYNLTGLCSRKYCGLANSKYATVREDGGGVYLYTKKAERAHKPAKLWEKIT 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 62078733    83 LNKNYEKALEQIDENLIYWPRFIRHKCKQRFTKITQY 119
Cdd:pfam01778  79 LSKNYRKALKQIDNHLKGYRPDLRHAAKQRASAILQS 115
 
Name Accession Description Interval E-value
PLN00040 PLN00040
Protein MAK16 homolog; Provisional
 1-194 7.06e-90

Protein MAK16 homolog; Provisional


Pssm-ID: 215038 [Multi-domain]  Cd Length: 233  Bit Score: 267.02  E-value: 7.06e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078733    1 MQSDDVIWNtLGNKQFCSYKIRTKTQGFCRNEYSLTGLCNRSSCPLANSQYATIKEEKGQCYLYMKVIERAAFPRRLWER 80
Cdd:PLN00040   1 MQHDEVIWQ-VINHNHCSFKAKIDTGNFCRNKYNVTGLCNRSSCPLANSRYATIREEDGRFYLYMKTIERAHMPNKLWEK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078733   81 VRLNKNYEKALEQIDENLIYWPRFIRHKCKQRFTKITQYLIRIRKLTLKRRKKLVPLSKKVERREKRREEKALIAAQLDN 160
Cdd:PLN00040  80 VKLSRNYEKALEQIDKHLAYWPKFLVHKNKQRLTKMTQYLIRMRKLALKTREKIVTTPRKLLKRERRRESKAQKAAQLEK 159

                        170       180       190
                 ....*....|....*....|....*....|....
gi 62078733  161 AIEKELLERLKQDTYGDIYNFPIHAFDKALEKQE 194
Cdd:PLN00040 160 SIEKELLERLKSGTYGDIYNFPSKSYNKVLEMEE 193
MAK16 COG5129
Nuclear protein with HMG-like acidic region [General function prediction only];
2-285 2.25e-70

Nuclear protein with HMG-like acidic region [General function prediction only];


Pssm-ID: 227458 [Multi-domain]  Cd Length: 303  Bit Score: 219.92  E-value: 2.25e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078733   2 QSDDVIWNTLGnKQFCSYKIRTKTQGFCRNEYSLTGLCNRSSCPLANSQYATIKEEKGQCYLYMKVIERAAFPRRLWERV 81
Cdd:COG5129   1 MSDESLWQVSG-ENFCSFRIKTEEQNFCRNEYNVTGLCDRQSCPLANSRYATVRADNGKLYLYMKTPERAHVPRKLWERI 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078733  82 RLNKNYEKALEQIDENLIYWPRFIRHKCKQRFTKITQYLIRIRKLTLKRR-KKLVPLSKKVERREKRREEKALIAAQLDN 160
Cdd:COG5129  80 KLSKNYEKALKQIDESLLFWDEKVIHKCKQRLTKLTQYLLKARRLALFKEhGEYMVRKPKMNRREKLRERKALNAAKFEK 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078733 161 AIEKELLERLKQDTYGDI-YNFPIHAFDKALEKQEAESDSEDEEDEEEDEEEDVgKREFVEDDEVEESDLSDFEDMDKLN 239
Cdd:COG5129 160 NIEKELMLRLKSGIYGDTpLNVREHLWNKAATEREKRQDEKERYVEEEEESDTE-LEAVTDDSEKEKTKKKDLEKWLGSD 238

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 62078733 240 TDSEEDDESSREEEAHKAKHKGKAPLKGPLRK---------KRAYVEIEYEQETE 285
Cdd:COG5129 239 QSMETSESEEEESSESESDEDEDEDNKGKIRKrktddakksRKPHIHIEYEQERE 293
Ribosomal_L28e pfam01778
Ribosomal L28e protein family;
6-119 6.82e-45

Ribosomal L28e protein family;


Pssm-ID: 460323  Cd Length: 115  Bit Score: 148.05  E-value: 6.82e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62078733     6 VIWNTLGNKQfcSYKIRTKT---QGFCRNEYSLTGLCNRSSCPLANSQYATIKEEKGQCYLYMKVIERAAFPRRLWERVR 82
Cdd:pfam01778   1 LIWEIIRNNN--SFLVKTRTgngQTFSREPYNLTGLCSRKYCGLANSKYATVREDGGGVYLYTKKAERAHKPAKLWEKIT 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 62078733    83 LNKNYEKALEQIDENLIYWPRFIRHKCKQRFTKITQY 119
Cdd:pfam01778  79 LSKNYRKALKQIDNHLKGYRPDLRHAAKQRASAILQS 115
Mak16 pfam04874
Mak16 protein C-terminal region; The precise function of this eukaryotic protein family is ...
 152-194 1.07e-20

Mak16 protein C-terminal region; The precise function of this eukaryotic protein family is unknown. The yeast orthologues have been implicated in cell cycle progression and biogenesis of 60S ribosomal subunits. The Schistosoma mansoni Mak16 has been shown to target protein transport to the nucleolus.


Pssm-ID: 461462  Cd Length: 97  Bit Score: 84.55  E-value: 1.07e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 62078733   152 ALIAAQLDNAIEKELLERLKQDTYGDIYNFPIHAFDKALEKQE 194
Cdd:pfam04874  15 ALAAAKLERAIEKELLERLKSGAYGDPYNFPEEAWDKVLEQEE 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH