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Conserved domains on  [gi|124486694|ref|NP_001074531|]
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cyclin-O [Mus musculus]

Protein Classification

cyclin-O( domain architecture ID 15334284)

cyclin-O is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_CCNO_rpt1 cd20536
first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required ...
 134-226 8.59e-50

first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410239  Cd Length: 93  Bit Score: 161.73  E-value: 8.59e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486694 134 SRCKLLSWLLQVHRQFGLSFESLCLTVNTLDRFLLTTPVAADCFQLLGVTCLLIACKQVEVHPPRLKQLLALCGGAFSRQ 213
Cdd:cd20536    1 MRAKLISWLIPVHRHFNLSQETLFLAVNILDRFLATTPVARDCFQLLGVTSLLIACKQEEIYPPEVKDLLALCCGAYTRE 80

                         90
                 ....*....|...
gi 124486694 214 QLCNLECIVLHKL 226
Cdd:cd20536   81 QICNLECIILTKL 93
CYCLIN_CCNO_rpt2 cd20722
second cyclin box found in cyclin-O (CCNO); CCNO is specifically required for generation of ...
 233-328 1.04e-35

second cyclin box found in cyclin-O (CCNO); CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410311  Cd Length: 97  Bit Score: 125.15  E-value: 1.04e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486694 233 PTINFFLEHFTQWRMEAGQ-AEVTEALEAQTLARGVAELSLTDYAFTTYTPSLMAICCLALADGLLQHQHEMDLRLGEHP 311
Cdd:cd20722    1 PTLQFFLEHFSSLRLENRElSCAEEARKARALARYLAELSLADYAFNQYPPSLLAICSLELADRMLQHRSPITERLSGYP 80

                         90
                 ....*....|....*..
gi 124486694 312 EATLQDCLGKLQTLVSI 328
Cdd:cd20722   81 QSALEDCVGKLRLLVSL 97
 
Name Accession Description Interval E-value
CYCLIN_CCNO_rpt1 cd20536
first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required ...
 134-226 8.59e-50

first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410239  Cd Length: 93  Bit Score: 161.73  E-value: 8.59e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486694 134 SRCKLLSWLLQVHRQFGLSFESLCLTVNTLDRFLLTTPVAADCFQLLGVTCLLIACKQVEVHPPRLKQLLALCGGAFSRQ 213
Cdd:cd20536    1 MRAKLISWLIPVHRHFNLSQETLFLAVNILDRFLATTPVARDCFQLLGVTSLLIACKQEEIYPPEVKDLLALCCGAYTRE 80

                         90
                 ....*....|...
gi 124486694 214 QLCNLECIVLHKL 226
Cdd:cd20536   81 QICNLECIILTKL 93
CYCLIN_CCNO_rpt2 cd20722
second cyclin box found in cyclin-O (CCNO); CCNO is specifically required for generation of ...
 233-328 1.04e-35

second cyclin box found in cyclin-O (CCNO); CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410311  Cd Length: 97  Bit Score: 125.15  E-value: 1.04e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486694 233 PTINFFLEHFTQWRMEAGQ-AEVTEALEAQTLARGVAELSLTDYAFTTYTPSLMAICCLALADGLLQHQHEMDLRLGEHP 311
Cdd:cd20722    1 PTLQFFLEHFSSLRLENRElSCAEEARKARALARYLAELSLADYAFNQYPPSLLAICSLELADRMLQHRSPITERLSGYP 80

                         90
                 ....*....|....*..
gi 124486694 312 EATLQDCLGKLQTLVSI 328
Cdd:cd20722   81 QSALEDCVGKLRLLVSL 97
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 108-231 6.23e-30

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 111.07  E-value: 6.23e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486694  108 YDFRKAQENLFHPRES-LARQPQVTAESRCKLLSWLLQVHRQFGLSFESLCLTVNTLDRFLLTTPVAADCFQLLGVTCLL 186
Cdd:pfam00134   3 FQYLRELELKYLPKPDyMDQQPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTCLF 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 124486694  187 IACKQVEVHPPRLKQLLALCGGAFSRQQLCNLECIVLHKLHFSLG 231
Cdd:pfam00134  83 IAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
124-338 6.38e-23

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 99.08  E-value: 6.38e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486694 124 LARQPQVTAESRCKLLSWLLQVHRQFGLSFESLCLTVNTLDRFLLTTPVAADCFQLLGVTCLLIACKQVEVHPPRLKQLL 203
Cdd:COG5024  202 LIKQSLYEWSMRSILVDWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVSLEKYQLVGISALFIASKYEEVNCPSIKDLV 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486694 204 ALCGGAFSRQQLCNLECIVLHKLHFSLGAPTINFFLEHFTqwrmeagQAEVTEAlEAQTLARGVAELSLTDYAFTTYTPS 283
Cdd:COG5024  282 YATDGAFTRDDIIRAERYMLEVLDFNISWPSPMSFLRRIS-------KASDYDI-FSRTPAKFSSEISPVDYKFIQISPS 353

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 124486694 284 LMAICCLALADGLL-QHQHEMDLR--LGEHPEATLQDCLGKLQTLVSINSSSLPRILP 338
Cdd:COG5024  354 WCAAAAMYLSRKILsQNQWDRTLIhySGNYTNPDLKPLNESNKENLQNPSVHHDAIFP 411
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 141-223 9.48e-16

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 71.47  E-value: 9.48e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486694   141 WLLQVHRQFGLSFESLCLTVNTLDRFLLTTPVAADCFQLLGVTCLLIACKQVEVHPPrLKQLLALCGGaFSRQQLCNLEC 220
Cdd:smart00385   2 FLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPW-TKELVHYTGY-FTEEEILRMER 79


                   ...
gi 124486694   221 IVL 223
Cdd:smart00385  80 LLL 82
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 233-301 1.76e-06

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 46.46  E-value: 1.76e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 124486694  233 PTINFFLEHFTQwrmeagQAEVTEALEAQTLARGVAELSLTDYAFTTYTPSLMAICCLALADGLLQHQH 301
Cdd:pfam02984   1 PTPLSFLRRFSK------AADYLHDLELRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTLNSPE 63
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 259-293 7.31e-03

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 35.26  E-value: 7.31e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 124486694   259 EAQTLARGVAELSLTDYAFTTYTPSLMAICCLALA 293
Cdd:smart00385  15 ETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLA 49
 
Name Accession Description Interval E-value
CYCLIN_CCNO_rpt1 cd20536
first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required ...
 134-226 8.59e-50

first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410239  Cd Length: 93  Bit Score: 161.73  E-value: 8.59e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486694 134 SRCKLLSWLLQVHRQFGLSFESLCLTVNTLDRFLLTTPVAADCFQLLGVTCLLIACKQVEVHPPRLKQLLALCGGAFSRQ 213
Cdd:cd20536    1 MRAKLISWLIPVHRHFNLSQETLFLAVNILDRFLATTPVARDCFQLLGVTSLLIACKQEEIYPPEVKDLLALCCGAYTRE 80

                         90
                 ....*....|...
gi 124486694 214 QLCNLECIVLHKL 226
Cdd:cd20536   81 QICNLECIILTKL 93
CYCLIN_CCNO_rpt2 cd20722
second cyclin box found in cyclin-O (CCNO); CCNO is specifically required for generation of ...
 233-328 1.04e-35

second cyclin box found in cyclin-O (CCNO); CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410311  Cd Length: 97  Bit Score: 125.15  E-value: 1.04e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486694 233 PTINFFLEHFTQWRMEAGQ-AEVTEALEAQTLARGVAELSLTDYAFTTYTPSLMAICCLALADGLLQHQHEMDLRLGEHP 311
Cdd:cd20722    1 PTLQFFLEHFSSLRLENRElSCAEEARKARALARYLAELSLADYAFNQYPPSLLAICSLELADRMLQHRSPITERLSGYP 80

                         90
                 ....*....|....*..
gi 124486694 312 EATLQDCLGKLQTLVSI 328
Cdd:cd20722   81 QSALEDCVGKLRLLVSL 97
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 102-228 3.83e-33

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 119.56  E-value: 3.83e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486694 102 EYGQSCYDFRKAQENLFHPRES-LARQPQVTAESRCKLLSWLLQVHRQFGLSFESLCLTVNTLDRFLLTTPVAADCFQLL 180
Cdd:cd20507    3 EYVKDIYKYLRQLEKKYAIDPDyLSGQPEITERMRAILVDWLVEVHLKFKLLPETLYLTVNIIDRYLSKKQVPRKKLQLV 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 124486694 181 GVTCLLIACKQVEVHPPRLKQLLALCGGAFSRQQLCNLECIVLHKLHF 228
Cdd:cd20507   83 GVTALLIASKYEEIYPPEIKDFVYITDNAYTREEILQMERDILKTLDF 130
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 108-231 6.23e-30

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 111.07  E-value: 6.23e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486694  108 YDFRKAQENLFHPRES-LARQPQVTAESRCKLLSWLLQVHRQFGLSFESLCLTVNTLDRFLLTTPVAADCFQLLGVTCLL 186
Cdd:pfam00134   3 FQYLRELELKYLPKPDyMDQQPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTCLF 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 124486694  187 IACKQVEVHPPRLKQLLALCGGAFSRQQLCNLECIVLHKLHFSLG 231
Cdd:pfam00134  83 IAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 102-228 3.88e-26

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 101.65  E-value: 3.88e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486694 102 EYGQSCYDFRKAQENLFHPRES-LARQPQVTAESRCKLLSWLLQVHRQFGLSFESLCLTVNTLDRFLLTTPVAADCFQLL 180
Cdd:cd20567   20 EYVEDIYSFYRKVEPESCVPPYyMSQQPDINEKMRAILIDWLIEVHLKFELMPETLYLTVNLIDRFLSVKQVPRKELQLV 99

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 124486694 181 GVTCLLIACKQVEVHPPRLKQLLALCGGAFSRQQLCNLECIVLHKLHF 228
Cdd:cd20567  100 GVTAMLIASKYEEIWAPEVNDFVYISDNAYTRKQILVMEKTMLNTLEF 147
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
 102-228 1.31e-24

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 96.98  E-value: 1.31e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486694 102 EYGQSCYDFRKAQENLFHPR-ESLARQPQVTAESRCKLLSWLLQVHRQFGLSFESLCLTVNTLDRFLLTTPVAADCFQLL 180
Cdd:cd20568    7 EYVPEIFEYLRELELKTLPNpNYMDDQKELRWKMRGILVDWLVEVHEKFRLLPETLFLAVNIIDRFLSKRVVSLNKLQLV 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 124486694 181 GVTCLLIACKQVEVHPPRLKQLLALCGGAFSRQQLCNLECIVLHKLHF 228
Cdd:cd20568   87 GISALFIASKYEEVNSPSIKNFAYMTDGAYTVEDILRAERYMLNTLEF 134
CYCLIN_CCNB3_rpt1 cd20508
first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is ...
 102-228 5.67e-24

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410212 [Multi-domain]  Cd Length: 142  Bit Score: 95.78  E-value: 5.67e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486694 102 EYGQSCYDFRKAQENLFHPRESLARQPQVTAESRCKLLSWLLQVHRQFGLSFESLCLTVNTLDRFLLTTPVAADCFQLLG 181
Cdd:cd20508   15 EYAKDIFDYMKEREEKFVVPDYLEKQTELTPSMRAILVDWLVEVQENFELNHETLYLAVKLVDLYLSKKVVKKEKLQLLG 94

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 124486694 182 VTCLLIACKQVEVHPPRLKQLLALCGGAFSRQQLCNLECIVLHKLHF 228
Cdd:cd20508   95 ATAILIASKFDERCPPCVDDFLYICDDAYTREELLKMEREILKTLDF 141
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 135-230 5.54e-23

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 91.61  E-value: 5.54e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486694 135 RCKLLSWLLQVHRQFGLSFESLCLTVNTLDRFLLTTPVAADCFQLLGVTCLLIACKQVEVHPPRLKQLLALCGGAFSRQQ 214
Cdd:cd20542    1 RAILVDWLVQVQEHLELSTQTLHLAVALLDRYLSRQKISLSLLQLLGITCLFIACKFEERFPPEVATLCYLTDDSYSKKQ 80

                         90
                 ....*....|....*.
gi 124486694 215 LCNLECIVLHKLHFSL 230
Cdd:cd20542   81 VLRMERRVLRRLRFDL 96
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
124-338 6.38e-23

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 99.08  E-value: 6.38e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486694 124 LARQPQVTAESRCKLLSWLLQVHRQFGLSFESLCLTVNTLDRFLLTTPVAADCFQLLGVTCLLIACKQVEVHPPRLKQLL 203
Cdd:COG5024  202 LIKQSLYEWSMRSILVDWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVSLEKYQLVGISALFIASKYEEVNCPSIKDLV 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486694 204 ALCGGAFSRQQLCNLECIVLHKLHFSLGAPTINFFLEHFTqwrmeagQAEVTEAlEAQTLARGVAELSLTDYAFTTYTPS 283
Cdd:COG5024  282 YATDGAFTRDDIIRAERYMLEVLDFNISWPSPMSFLRRIS-------KASDYDI-FSRTPAKFSSEISPVDYKFIQISPS 353

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 124486694 284 LMAICCLALADGLL-QHQHEMDLR--LGEHPEATLQDCLGKLQTLVSINSSSLPRILP 338
Cdd:COG5024  354 WCAAAAMYLSRKILsQNQWDRTLIhySGNYTNPDLKPLNESNKENLQNPSVHHDAIFP 411
CYCLIN_CCNA_rpt1 cd20504
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 102-228 5.03e-20

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410208 [Multi-domain]  Cd Length: 128  Bit Score: 84.61  E-value: 5.03e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486694 102 EYGQSCYDFRKAQENLFHPRES-LARQPQVTAESRCKLLSWLLQVHRQFGLSFESLCLTVNTLDRFLLTTPVAADCFQLL 180
Cdd:cd20504    1 EYADDIYEYLRESELKHRPKPDyMRKQPDINPSMRSILVDWLVEVAEEYKLVPETLYLAVNYIDRFLSQMSVLRSKLQLV 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 124486694 181 GVTCLLIACKQVEVHPPRLKQLLALCGGAFSRQQLCNLECIVLHKLHF 228
Cdd:cd20504   81 GTACMFIAAKYEEIYPPEVEEFVYITDDTYTKKQVLRMEHLVLKVLSF 128
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 127-228 4.53e-19

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 82.07  E-value: 4.53e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486694 127 QPQVTAESRCKLLSWLLQVHRQFGLSFESLCLTVNTLDRFLLTTPVAADCFQLLGVTCLLIACKQVEVHPPRLKQLLALC 206
Cdd:cd20562   34 QRDITPSMRGILVDWLVEVAEEYKLVPDTLYLTVSYIDRFLSGNYVNRQRLQLLGVSCMLIASKYEEICAPQVEEFCYIT 113

                         90       100
                 ....*....|....*....|..
gi 124486694 207 GGAFSRQQLCNLECIVLHKLHF 228
Cdd:cd20562  114 DNTYTKQEVLEMEIDVLNALQF 135
CYCLIN_CCNA2_rpt1 cd20561
first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S ...
 102-228 2.20e-17

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410264 [Multi-domain]  Cd Length: 131  Bit Score: 77.41  E-value: 2.20e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486694 102 EYGQSCYDFRKAQENLFHPRES-LARQPQVTAESRCKLLSWLLQVHRQFGLSFESLCLTVNTLDRFLLTTPVAADCFQLL 180
Cdd:cd20561    3 DYHEDIHTYLREMEVKCKPKVGyMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLV 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 124486694 181 GVTCLLIACKQVEVHPPRLKQLLALCGGAFSRQQLCNLECIVLHKLHF 228
Cdd:cd20561   83 GTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTF 130
CYCLIN_CCNA1_rpt1 cd20560
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ...
 83-228 6.01e-17

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410263  Cd Length: 163  Bit Score: 77.19  E-value: 6.01e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486694  83 SSLLNPAQPLTALDLQTF--REYGQSCYDFRKAQENLFHPRESLAR-QPQVTAESRCKLLSWLLQVHRQFGLSFESLCLT 159
Cdd:cd20560   14 TSLQSQSEDDSAADVDVLavPEYAEDIHQYLREAELKHRPKPGYMRkQPDITTGMRTILVDWLVEVGEEYKLQTETLYLA 93

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 124486694 160 VNTLDRFLLTTPVAADCFQLLGVTCLLIACKQVEVHPPRLKQLLALCGGAFSRQQLCNLECIVLHKLHF 228
Cdd:cd20560   94 VNYLDRFLSCMSVLRGKLQLVGTAAILLASKYEEIYPPEVDEFVYITDDTYTKKQLLRMEHLLLKVLAF 162
CYCLIN_CCNB2_rpt1 cd20566
first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is ...
 135-228 9.88e-17

first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410269 [Multi-domain]  Cd Length: 133  Bit Score: 75.67  E-value: 9.88e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486694 135 RCKLLSWLLQVHRQFGLSFESLCLTVNTLDRFLLTTPVAADCFQLLGVTCLLIACKQVEVHPPRLKQLLALCGGAFSRQQ 214
Cdd:cd20566   40 RAILVDWLVQVHSRFQLLQETLYMCVAIMDRFLQVQPVSRKKLQLVGVTALLLASKYEEMYSPEIGDFVYITDNAYTKAQ 119

                         90
                 ....*....|....
gi 124486694 215 LCNLECIVLHKLHF 228
Cdd:cd20566  120 IREMEMLILKELNF 133
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 111-228 6.74e-16

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 73.50  E-value: 6.74e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486694 111 RKAQENLFHPRESLARQPQVTAESRCKLLSWLLQVHRQFGLSFESLCLTVNTLDRFLLT-TPVAADCFQLLGVTCLLIAC 189
Cdd:cd20519   13 LKKEELYKRDRDFLNRHPSLQPRMRAILLDWLMEVCEVYRLHRETFYLAVDFVDRYLSTqTNVPKTQLQLIGITCLFIAA 92

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 124486694 190 KQVEVHPPRLKQLLALCGGAFSRQQLCNLECIVLHKLHF 228
Cdd:cd20519   93 KLEEIYPPKLSEFAYVTDGACTEDEILTMELIILKALNW 131
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 141-223 9.48e-16

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 71.47  E-value: 9.48e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486694   141 WLLQVHRQFGLSFESLCLTVNTLDRFLLTTPVAADCFQLLGVTCLLIACKQVEVHPPrLKQLLALCGGaFSRQQLCNLEC 220
Cdd:smart00385   2 FLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPW-TKELVHYTGY-FTEEEILRMER 79


                   ...
gi 124486694   221 IVL 223
Cdd:smart00385  80 LLL 82
CYCLIN_CCNB1_rpt1 cd20565
first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the ...
 102-228 1.06e-15

first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410268 [Multi-domain]  Cd Length: 129  Bit Score: 72.60  E-value: 1.06e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486694 102 EYGQSCYDFRKAQENLFHPRESLARQPQVTAESRCKLLSWLLQVHRQFGLSFESLCLTVNTLDRFLLTTPVAADCFQLLG 181
Cdd:cd20565    3 EYVKDIYAYLRQLEEEQAVRPKYLEGQEVTGNMRAILIDWLVQVQMKFRLLQETMYMTVAIIDRFLQNNPVPKKMLQLVG 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 124486694 182 VTCLLIACKQVEVHPPRLKQLLALCGGAFSRQQLCNLECIVLHKLHF 228
Cdd:cd20565   83 VTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALDF 129
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 124-226 9.80e-14

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 67.60  E-value: 9.80e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486694 124 LARQPQVTAESRCKLLSWLLQVHRQFGLSFESLCLTVNTLDRFLLTTP-VAADCFQLLGVTCLLIACKQVEVHPPRLKQL 202
Cdd:cd20579   32 LQKHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATQEnVVKTRLQLIGISSLFIAAKLEEIYPPKLHQF 111

                         90       100
                 ....*....|....*....|....
gi 124486694 203 LALCGGAFSRQQLCNLECIVLHKL 226
Cdd:cd20579  112 AYVTDGACTEDEILSMELIIMKAL 135
CYCLIN_CCNE2_rpt1 cd20580
first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 119-226 6.20e-13

first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410283 [Multi-domain]  Cd Length: 137  Bit Score: 65.25  E-value: 6.20e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486694 119 HPRESLARQPQVTAESRCKLLSWLLQVHRQFGLSFESLCLTVNTLDRFLLT-TPVAADCFQLLGVTCLLIACKQVEVHPP 197
Cdd:cd20580   27 HDKHFLQLHPALQPKMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTqKNINKSMLQLIGITSLFIASKLEEIYPP 106

                         90       100
                 ....*....|....*....|....*....
gi 124486694 198 RLKQLLALCGGAFSRQQLCNLECIVLHKL 226
Cdd:cd20580  107 KLHEFAYVTDGACSEDDILDMELIILKAL 135
CYCLIN_vCyC_rpt1 cd20517
first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle ...
 130-226 7.94e-13

first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle progression and apoptotic signaling pathways. It forms an active kinase complex with cellular CDK6, a cellular cyclin-dependent kinase known to interact with cellular type D cyclins. v-Cyclin belongs to Cyclin D subfamily. It contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410221  Cd Length: 99  Bit Score: 63.73  E-value: 7.94e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486694 130 VTAESRCKLLSWLLQVHRQFGLSFESLCLTVNTLDRFLLTTPVAADCFQLLGVTCLLIACKQVEVHPPRLKQLLALCGGA 209
Cdd:cd20517    1 VTSDNRKILLTWMFLVCESFELDKNVFPLAVSLLDRLLLKKQGTKETLQKTGAACLLIASKIRTVKPITVSKLTYLSCDC 80

                         90
                 ....*....|....*..
gi 124486694 210 FSRQQLCNLECIVLHKL 226
Cdd:cd20517   81 FTNLELINQEKDILEAL 97
CYCLIN_ScCLN_like cd20559
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ...
 138-226 8.44e-13

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410262 [Multi-domain]  Cd Length: 95  Bit Score: 63.56  E-value: 8.44e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486694 138 LLSWLLQVHRQFGLSFESLCLTVNTLDRFLLTTPVAADCFQLLGVTCLLIACKQVEVHP--PRLKQLLALCGGAFSRQQL 215
Cdd:cd20559    2 LLDFLFELHVELRLSPQTFFLSVNLIDRYCSKRIVLKKHYQLVGCTCLWIASKFWESKArvPLLSELSKMCCNSYGEELF 81

                         90
                 ....*....|.
gi 124486694 216 CNLECIVLHKL 226
Cdd:cd20559   82 IQMEMHILNTL 92
CYCLIN_CCND3_rpt1 cd20575
first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a ...
 114-226 5.60e-11

first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410278  Cd Length: 150  Bit Score: 60.00  E-value: 5.60e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486694 114 QENLFHPRESLAR--QPQVTAESRCKLLSWLLQVHRQFGLSFESLCLTVNTLDRFLLTTPVAADCFQLLGVTCLLIACKQ 191
Cdd:cd20575   33 LEERYVPRVSYFQcvQREIKPYMRKMLAYWMLEVCEEQKCEEEVFPLAMNYVDRYLSCVPTRKAQLQLLGAVCMLLASKL 112

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 124486694 192 VEVHPPRLKQLLALCGGAFSRQQLCNLECIVLHKL 226
Cdd:cd20575  113 RETTPLTIEKLCIYTDNSISPRQLLDWEILVLGKL 147
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 137-221 2.87e-10

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 56.26  E-value: 2.87e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486694 137 KLLSWLLQVHRQFGLSFESLCLTVNTLDRFLLTTPVAADCFQLLGVTCLLIACKQVEvHPPRLKQLLALCGgaFSRQQLC 216
Cdd:cd00043    1 KAVDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEE-LPRTLKEIAKVSG--VSEKELR 77


                 ....*
gi 124486694 217 NLECI 221
Cdd:cd00043   78 KAEKE 82
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 133-228 1.67e-09

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 54.53  E-value: 1.67e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486694 133 ESRCKLLSWLLQVHRQFGLSFESLCLTVNTLDRFLLTTPVAADCFQLLGVTCLLIACKQVEV--HPPRLKQLL-ALCGGA 209
Cdd:cd20528    5 HLRRYLVDWLAVVSERLKLSDTTLHLAVYLLDRFMDRYDISEDQLHLVALTCLLLAAKFEELddNIPKISDLNrYLCNSV 84

                         90
                 ....*....|....*....
gi 124486694 210 FSRQQLCNLECIVLHKLHF 228
Cdd:cd20528   85 YSKQEYLQMELLILEFFQW 103
CYCLIN_CCND_rpt1 cd20515
first cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 127-226 2.17e-09

first cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410219  Cd Length: 150  Bit Score: 55.38  E-value: 2.17e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486694 127 QPQVTAESRCKLLSWLLQVHRQFGLSFESLCLTVNTLDRFLLTTPVAADCFQLLGVTCLLIACKQVEVHPPRLKQLLALC 206
Cdd:cd20515   48 QTEIQPFMRKMVTTWMLEVCEEQNCEEEVFPLAVNYLDRFLSLVPIRKSQLQLLGAVCLFLASKLKETIPLTAEKLCIYT 127

                         90       100
                 ....*....|....*....|
gi 124486694 207 GGAFSRQQLCNLECIVLHKL 226
Cdd:cd20515  128 DNSITLQELLDWELLVLTKL 147
CYCLIN_CCNO-like_rpt2 cd20537
second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of ...
 233-327 3.79e-09

second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of CCNO and similar proteins including Schizosaccharomyces pombe meiosis-specific cyclin rem1, Drosophila melanogaster G2/mitotic-specific cyclin-A (CCNA), and Candida albicans G1/S-specific cyclin CCN1, among others. Rem1 is required for pre-meiotic DNA synthesis and S phase progression. CCNA is essential for the control of the cell cycle at the G2/M (mitosis) transition. CCN1 is essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It is involved in the activation of cyclin-dependent kinase 2. Members of this subfamily contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410240 [Multi-domain]  Cd Length: 91  Bit Score: 53.08  E-value: 3.79e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486694 233 PTINFFLEHFtqwrMEAGQAEvteaLEAQTLARGVAELSLTDYAFTTYTPSLMAICCLALADGLLQHQHEMDLRL---GE 309
Cdd:cd20537    1 PTPLSFLRRY----LSLLGLD----EKVRHLARYLLELSLLDYEFLKYRPSLIAAAALYLARKILGEPPPSPQLLqlvTG 72

                         90
                 ....*....|....*...
gi 124486694 310 HPEATLQDCLGKLQTLVS 327
Cdd:cd20537   73 YSENDLQECAKELLELLA 90
CYCLIN_CCNI-like cd20526
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ...
 141-230 4.50e-09

cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.


Pssm-ID: 410230  Cd Length: 99  Bit Score: 53.08  E-value: 4.50e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486694 141 WLLQVHRQFGLSFESLCLTVNTLDRFLLTTPVAADCFQLLGVTCLLIACKQVEVHP--PRLKQLLALCGGAFSRQQLCNL 218
Cdd:cd20526    8 WLAELNSQFKFYPETFALAVSILDRFLASVKARPKYLRCIAISCLFLAAKTNEEDEviPSTKDLVRVSKCGCSVAEVLRM 87

                         90
                 ....*....|..
gi 124486694 219 ECIVLHKLHFSL 230
Cdd:cd20526   88 ERIILDKLHWDL 99
CYCLIN_CCND1_rpt1 cd20573
first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ...
 127-226 4.71e-08

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410276  Cd Length: 149  Bit Score: 51.52  E-value: 4.71e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486694 127 QPQVTAESRCKLLSWLLQVHRQFGLSFESLCLTVNTLDRFLLTTPVAADCFQLLGVTCLLIACKQVEVHPPRLKQLLALC 206
Cdd:cd20573   47 QKEILPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSVEPTKKSRLQLLGATCMFLASKMKETIPLTAEKLCIYT 126

                         90       100
                 ....*....|....*....|
gi 124486694 207 GGAFSRQQLCNLECIVLHKL 226
Cdd:cd20573  127 DNSIRPEELLQMELLVLNKL 146
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 135-202 7.99e-08

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 49.62  E-value: 7.99e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124486694 135 RCKLLSWLLQVHRQFGLSFESLCLTVNTLDRFLLTTPVAAD---CFQLLGVTCLLIACKQVEVHPPRLKQL 202
Cdd:cd20543    2 RNEAIDWILKVRSRYGFGPLTAYLAVNYLDRFLSSYDLPKDkpwMLQLLAVACLSLAAKMEETDVPLLVDL 72
CYCLIN_CCND2_rpt1 cd20574
first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ...
 140-229 2.19e-07

first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410277  Cd Length: 150  Bit Score: 49.61  E-value: 2.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486694 140 SWLLQVHRQFGLSFESLCLTVNTLDRFLLTTPVAADCFQLLGVTCLLIACKQVEVHPPRLKQLLALCGGAFSRQQLCNLE 219
Cdd:cd20574   61 TWMLEVCEEQKCEEEVFPLAMNYLDRFLAVVPTRKCHLQLLGAVCMFLASKLKETIPLTAEKLCIYTDNSIKPQELLEWE 140

                         90
                 ....*....|
gi 124486694 220 CIVLHKLHFS 229
Cdd:cd20574  141 LVVLGKLKWN 150
CYCLIN_AtCycA-like_rpt2 cd20506
second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 233-336 3.15e-07

second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410210  Cd Length: 111  Bit Score: 48.40  E-value: 3.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486694 233 PTINFFLEHFTQwrmeAGQAEVTEaLEAQTLARGVAELSLTDYAFTTYTPSLMAICCLALADGLLqHQHEMDLRLgEH-- 310
Cdd:cd20506    1 PTIKTFLRRFLR----AAQASVPD-LKLEFLANYLAELSLLDYEFLKYLPSLIAASAVFLARHTL-NPHPWNPTL-EHyt 73

                         90       100
                 ....*....|....*....|....*....
gi 124486694 311 --PEATLQDCLGKLQTL-VSINSSSLPRI 336
Cdd:cd20506   74 gyKAADLKPCVQALHDLqLNASGSSLQAV 102
CYCLIN_CCNF_rpt1 cd20521
first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also ...
 133-188 1.13e-06

first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410225  Cd Length: 95  Bit Score: 46.16  E-value: 1.13e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 124486694 133 ESRCKLLSWLLQVHRQFGLSFESLCLTVNTLDRFLLTTPVAADCFQLLGVTCLLIA 188
Cdd:cd20521    2 TMRYILVDWLVEVATMKDFSSLTLHVAVSCVDRYLMVRKVPRSKLQLLGIACMVIA 57
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 233-301 1.76e-06

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 46.46  E-value: 1.76e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 124486694  233 PTINFFLEHFTQwrmeagQAEVTEALEAQTLARGVAELSLTDYAFTTYTPSLMAICCLALADGLLQHQH 301
Cdd:pfam02984   1 PTPLSFLRRFSK------AADYLHDLELRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTLNSPE 63
CYCLIN_CCNG cd20523
cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 ...
 142-226 3.06e-06

cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 and CCNG2. CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410227  Cd Length: 94  Bit Score: 45.04  E-value: 3.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486694 142 LLQVHRQFGLSFESLCLTVNTLDRFLLTTPVAADCFQLLGVTCLLIACKQVEVH--PPRLKQLLALCGGAFSRQQLCNLE 219
Cdd:cd20523    8 LRCLHRFYGFSPETFALAVNLLDRFLSKVKVKPKHLACITVSCFHIAIKSVEEDqnIPSAEDLIRISQCGCTAADLMRME 87


                 ....*..
gi 124486694 220 CIVLHKL 226
Cdd:cd20523   88 GIILEKL 94
CYCLIN_CCNG1 cd20583
cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has ...
 142-226 4.98e-06

cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG1 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410286  Cd Length: 98  Bit Score: 44.43  E-value: 4.98e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486694 142 LLQVHRQFGLSFESLCLTVNTLDRFLLTTPVAADCFQLLGVTCLLIACKQVEVHP--PRLKQLLALCGGAFSRQQLCNLE 219
Cdd:cd20583    9 LLSLTQFFGFSTETFSLAVNLLDRFLAKMKVQPKHLGCVGLSCFYLAVKAIEEERnvPLATDLIRISQYRFTVSDMMRME 88


                 ....*..
gi 124486694 220 CIVLHKL 226
Cdd:cd20583   89 KIILEKL 95
CYCLIN_CCNB3_rpt2 cd20510
second cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 ...
 258-293 2.26e-05

second cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410214  Cd Length: 115  Bit Score: 43.04  E-value: 2.26e-05
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 124486694 258 LEAQTLARGVAELSLTDYAFTTYTPSLMAICCLALA 293
Cdd:cd20510   18 METLTLARYILELSLMEYQFVQERASKLAAAALLLA 53
CYCLIN_CCNG2 cd20584
cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth ...
 149-227 6.98e-05

cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. CCNG2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410287  Cd Length: 96  Bit Score: 41.37  E-value: 6.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486694 149 FGLSFESLCLTVNTLDRFLLTTPVAADCFQLLGVTCLLIACKQVE--VHPPRLKQLLALCGGAFSRQQLCNLECIVLHKL 226
Cdd:cd20584   16 FGFSTETFVLAVNILDRFLALMKVKPKHLSCIGICCFHLAARVVEeeCNIPSSHDLIRISQCKCTVSDLKRMEKIISEKL 95


                 .
gi 124486694 227 H 227
Cdd:cd20584   96 H 96
CYCLIN_CCNB2_rpt2 cd20570
second cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 ...
 241-300 2.30e-03

second cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410273  Cd Length: 119  Bit Score: 37.55  E-value: 2.30e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486694 241 HFTQWRMEAGQAEVtealEAQTLARGVAELSLTDYAFTTYTPSLMAICCLALADGLLQHQ 300
Cdd:cd20570    5 HFLRRASKAGSADV----EKHTLAKYLMELTLIDYDMVHYHPSEIAAAALCLSQKVLDGG 60
CYCLIN_CCNH_rpt1 cd20524
first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 182-230 7.21e-03

first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410228  Cd Length: 150  Bit Score: 36.42  E-value: 7.21e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 124486694 182 VTCLLIACKqVEVHPPRLKQLLALCGGAFSR-QQLCNLECIVLHKLHFSL 230
Cdd:cd20524  102 LTCLYLACK-VEEFNISIDQFVGNIKESEKTaEIILEYELLLLQGLNFHL 150
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 259-293 7.31e-03

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 35.26  E-value: 7.31e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 124486694   259 EAQTLARGVAELSLTDYAFTTYTPSLMAICCLALA 293
Cdd:smart00385  15 ETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLA 49
CYCLIN_CCNA_rpt2 cd20505
second cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 233-293 8.22e-03

second cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410209 [Multi-domain]  Cd Length: 110  Bit Score: 35.73  E-value: 8.22e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 124486694 233 PTINFFLEHFTQWrmeagqAEVTEALeaQTLARGVAELSLTDY-AFTTYTPSLMAICCLALA 293
Cdd:cd20505    1 PTSNWFLERFLKH------SNADEKT--KSLAMYLCELSLIDAdPYLKYLPSVIAAAAVCLA 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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