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Conserved domains on  [gi|149773449|ref|NP_001092690|]
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zinc finger protein 862 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
333-393 1.32e-28

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 109.22  E-value: 1.32e-28
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 149773449    333 VVFEDVAVYFTREEWGMLDKRQKELYRDVMRMNYELLASLGPAAAKPDLISKLERRAAPWI 393
Cdd:smart00349    1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
ZnF_TTF smart00597
zinc finger in transposases and transcription factors;
135-218 1.47e-26

zinc finger in transposases and transcription factors;


:

Pssm-ID: 214739  Cd Length: 91  Bit Score: 104.49  E-value: 1.47e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149773449    135 KPRSIQKSWFVQFP-WLIMNEEQTALFCSACREYPSIRDKRSRLI--EGYTgPFKVET--LKYHAKSKAHMF---CVNAL 206
Cdd:smart00597    1 KPRRFQKSWFHQFPdWLEYSVEKDAAFCKYCYLFRPGRDGGSDLFvtEGFC-SWKKERirLKQHEVSKRHRNarlCVNLM 79

                            90
                    ....*....|..
gi 149773449    207 AARDPIWAARFR 218
Cdd:smart00597   80 EQRQSILRAHLK 91
ZnF_TTF super family cl02692
zinc finger in transposases and transcription factors;
461-544 1.00e-22

zinc finger in transposases and transcription factors;


The actual alignment was detected with superfamily member smart00597:

Pssm-ID: 214739  Cd Length: 91  Bit Score: 93.32  E-value: 1.00e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149773449    461 RPRSIQRSWFGQFP-WLVIDPKETKLFCSACIE-RPNLHDKSSRLV-RGYTgPFKVET--LKYHEVSKAHR---LCVNTV 532
Cdd:smart00597    1 KPRRFQKSWFHQFPdWLEYSVEKDAAFCKYCYLfRPGRDGGSDLFVtEGFC-SWKKERirLKQHEVSKRHRnarLCVNLM 79

                            90
                    ....*....|..
gi 149773449    533 EIKEDTPHTALV 544
Cdd:smart00597   80 EQRQSILRAHLK 91
KRAB super family cl42959
krueppel associated box;
11-65 6.24e-10

krueppel associated box;


The actual alignment was detected with superfamily member smart00349:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 56.06  E-value: 6.24e-10
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 149773449     11 VTFDDITVYLLQEEWVLLSQQQKELCGSNKL-----VAPLGPTVANPELFRKFGRGPEPW 65
Cdd:smart00349    1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLenysnLVSLGFQVPKPDLISQLEQGEEPW 60
DUF4371 super family cl46273
Domain of unknown function (DUF4371);
503-707 9.11e-09

Domain of unknown function (DUF4371);


The actual alignment was detected with superfamily member pfam14291:

Pssm-ID: 480613  Cd Length: 236  Bit Score: 57.24  E-value: 9.11e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149773449   503 LVRGYTGPFKVETL---KYHEVSKAHRLCVNTVE---IKEDTPHTALVPEISSDLMAN---MEHFFNAAYSIAYHSRPL- 572
Cdd:pfam14291    4 LSTGFCSWNKADRLdqfVGHQVNSFHNIAKRKCEdlmRQGQSIKHILHKETDLEKNDYriwLKASIDIIIHLLHQGLPLr 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149773449   573 NDFEK-----------ILQLLQSTGTVI-----LGKyRNRTACTQFIK-----YISETLKREILEDVRNSPcVSVLLDSS 631
Cdd:pfam14291   84 GHDESeestnkglfveLLKYTAGQDEVVkkvlkNAP-KNNTYTSPPIQndivnCFSNEVTRSIIEEMDNDV-FGILVDET 161

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 149773449   632 TDASEQACVGIYIRYFKQM-EVKESYITLAPLYSETADGYFETIVSALDELDIPFRKpgwVVGLGTDG-SAMLSCRGG 707
Cdd:pfam14291  162 ADASDKEQMAIVFRYVDKYgVPIERFIGVIHVQETSSLSLKSAIDSLLKSLGISLKK---LRSQCYDGaSNMSGEFNG 236
Dimer_Tnp_hAT super family cl05324
hAT family C-terminal dimerization region; This dimerization region is found at the C terminus ...
 990-1066 1.79e-05

hAT family C-terminal dimerization region; This dimerization region is found at the C terminus of the transposases of elements belonging to the Activator superfamily (hAT element superfamily). The isolated dimerization region forms extremely stable dimers in vitro.


The actual alignment was detected with superfamily member pfam05699:

Pssm-ID: 399013  Cd Length: 83  Bit Score: 44.17  E-value: 1.79e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149773449   990 LEEWLGLKTIAQHLPFSMLC---KNalaqHCRFPLLSKLMAVVVCVPISTSCCERGFKAMNRIRTDERTKLSNEVLNMLM 1066
Cdd:pfam05699    2 LDQYLSEPVLPRNEDFDPLEwwkEN----SSRYPNLSKLARDILSIPVSSAASERSFSTLGKVILESRNRLEPLNVEALL 77
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
333-393 1.32e-28

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 109.22  E-value: 1.32e-28
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 149773449    333 VVFEDVAVYFTREEWGMLDKRQKELYRDVMRMNYELLASLGPAAAKPDLISKLERRAAPWI 393
Cdd:smart00349    1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
ZnF_TTF smart00597
zinc finger in transposases and transcription factors;
135-218 1.47e-26

zinc finger in transposases and transcription factors;


Pssm-ID: 214739  Cd Length: 91  Bit Score: 104.49  E-value: 1.47e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149773449    135 KPRSIQKSWFVQFP-WLIMNEEQTALFCSACREYPSIRDKRSRLI--EGYTgPFKVET--LKYHAKSKAHMF---CVNAL 206
Cdd:smart00597    1 KPRRFQKSWFHQFPdWLEYSVEKDAAFCKYCYLFRPGRDGGSDLFvtEGFC-SWKKERirLKQHEVSKRHRNarlCVNLM 79

                            90
                    ....*....|..
gi 149773449    207 AARDPIWAARFR 218
Cdd:smart00597   80 EQRQSILRAHLK 91
ZnF_TTF smart00597
zinc finger in transposases and transcription factors;
461-544 1.00e-22

zinc finger in transposases and transcription factors;


Pssm-ID: 214739  Cd Length: 91  Bit Score: 93.32  E-value: 1.00e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149773449    461 RPRSIQRSWFGQFP-WLVIDPKETKLFCSACIE-RPNLHDKSSRLV-RGYTgPFKVET--LKYHEVSKAHR---LCVNTV 532
Cdd:smart00597    1 KPRRFQKSWFHQFPdWLEYSVEKDAAFCKYCYLfRPGRDGGSDLFVtEGFC-SWKKERirLKQHEVSKRHRnarLCVNLM 79

                            90
                    ....*....|..
gi 149773449    533 EIKEDTPHTALV 544
Cdd:smart00597   80 EQRQSILRAHLK 91
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 332-373 1.42e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 82.90  E-value: 1.42e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 149773449   332 PVVFEDVAVYFTREEWGMLDKRQKELYRDVMRMNYELLASLG 373
Cdd:pfam01352    1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 335-372 1.87e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 76.82  E-value: 1.87e-17
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 149773449  335 FEDVAVYFTREEWGMLDKRQKELYRDVMRMNYELLASL 372
Cdd:cd07765     3 FEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
KRAB smart00349
krueppel associated box;
11-65 6.24e-10

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 56.06  E-value: 6.24e-10
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 149773449     11 VTFDDITVYLLQEEWVLLSQQQKELCGSNKL-----VAPLGPTVANPELFRKFGRGPEPW 65
Cdd:smart00349    1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLenysnLVSLGFQVPKPDLISQLEQGEEPW 60
DUF4371 pfam14291
Domain of unknown function (DUF4371);
503-707 9.11e-09

Domain of unknown function (DUF4371);


Pssm-ID: 405048  Cd Length: 236  Bit Score: 57.24  E-value: 9.11e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149773449   503 LVRGYTGPFKVETL---KYHEVSKAHRLCVNTVE---IKEDTPHTALVPEISSDLMAN---MEHFFNAAYSIAYHSRPL- 572
Cdd:pfam14291    4 LSTGFCSWNKADRLdqfVGHQVNSFHNIAKRKCEdlmRQGQSIKHILHKETDLEKNDYriwLKASIDIIIHLLHQGLPLr 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149773449   573 NDFEK-----------ILQLLQSTGTVI-----LGKyRNRTACTQFIK-----YISETLKREILEDVRNSPcVSVLLDSS 631
Cdd:pfam14291   84 GHDESeestnkglfveLLKYTAGQDEVVkkvlkNAP-KNNTYTSPPIQndivnCFSNEVTRSIIEEMDNDV-FGILVDET 161

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 149773449   632 TDASEQACVGIYIRYFKQM-EVKESYITLAPLYSETADGYFETIVSALDELDIPFRKpgwVVGLGTDG-SAMLSCRGG 707
Cdd:pfam14291  162 ADASDKEQMAIVFRYVDKYgVPIERFIGVIHVQETSSLSLKSAIDSLLKSLGISLKK---LRSQCYDGaSNMSGEFNG 236
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 11-41 1.45e-07

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 48.70  E-value: 1.45e-07
                          10        20        30
                  ....*....|....*....|....*....|.
gi 149773449   11 VTFDDITVYLLQEEWVLLSQQQKELCGSNKL 41
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVML 31
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 10-36 6.05e-07

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 47.08  E-value: 6.05e-07
                           10        20
                   ....*....|....*....|....*..
gi 149773449    10 PVTFDDITVYLLQEEWVLLSQQQKELC 36
Cdd:pfam01352    1 SVTFEDVAVDFTQEEWALLDPAQRNLY 27
Dimer_Tnp_hAT pfam05699
hAT family C-terminal dimerization region; This dimerization region is found at the C terminus ...
 990-1066 1.79e-05

hAT family C-terminal dimerization region; This dimerization region is found at the C terminus of the transposases of elements belonging to the Activator superfamily (hAT element superfamily). The isolated dimerization region forms extremely stable dimers in vitro.


Pssm-ID: 399013  Cd Length: 83  Bit Score: 44.17  E-value: 1.79e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149773449   990 LEEWLGLKTIAQHLPFSMLC---KNalaqHCRFPLLSKLMAVVVCVPISTSCCERGFKAMNRIRTDERTKLSNEVLNMLM 1066
Cdd:pfam05699    2 LDQYLSEPVLPRNEDFDPLEwwkEN----SSRYPNLSKLARDILSIPVSSAASERSFSTLGKVILESRNRLEPLNVEALL 77
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
333-393 1.32e-28

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 109.22  E-value: 1.32e-28
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 149773449    333 VVFEDVAVYFTREEWGMLDKRQKELYRDVMRMNYELLASLGPAAAKPDLISKLERRAAPWI 393
Cdd:smart00349    1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
ZnF_TTF smart00597
zinc finger in transposases and transcription factors;
135-218 1.47e-26

zinc finger in transposases and transcription factors;


Pssm-ID: 214739  Cd Length: 91  Bit Score: 104.49  E-value: 1.47e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149773449    135 KPRSIQKSWFVQFP-WLIMNEEQTALFCSACREYPSIRDKRSRLI--EGYTgPFKVET--LKYHAKSKAHMF---CVNAL 206
Cdd:smart00597    1 KPRRFQKSWFHQFPdWLEYSVEKDAAFCKYCYLFRPGRDGGSDLFvtEGFC-SWKKERirLKQHEVSKRHRNarlCVNLM 79

                            90
                    ....*....|..
gi 149773449    207 AARDPIWAARFR 218
Cdd:smart00597   80 EQRQSILRAHLK 91
ZnF_TTF smart00597
zinc finger in transposases and transcription factors;
461-544 1.00e-22

zinc finger in transposases and transcription factors;


Pssm-ID: 214739  Cd Length: 91  Bit Score: 93.32  E-value: 1.00e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149773449    461 RPRSIQRSWFGQFP-WLVIDPKETKLFCSACIE-RPNLHDKSSRLV-RGYTgPFKVET--LKYHEVSKAHR---LCVNTV 532
Cdd:smart00597    1 KPRRFQKSWFHQFPdWLEYSVEKDAAFCKYCYLfRPGRDGGSDLFVtEGFC-SWKKERirLKQHEVSKRHRnarLCVNLM 79

                            90
                    ....*....|..
gi 149773449    533 EIKEDTPHTALV 544
Cdd:smart00597   80 EQRQSILRAHLK 91
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 332-373 1.42e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 82.90  E-value: 1.42e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 149773449   332 PVVFEDVAVYFTREEWGMLDKRQKELYRDVMRMNYELLASLG 373
Cdd:pfam01352    1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 335-372 1.87e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 76.82  E-value: 1.87e-17
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 149773449  335 FEDVAVYFTREEWGMLDKRQKELYRDVMRMNYELLASL 372
Cdd:cd07765     3 FEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
KRAB smart00349
krueppel associated box;
11-65 6.24e-10

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 56.06  E-value: 6.24e-10
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 149773449     11 VTFDDITVYLLQEEWVLLSQQQKELCGSNKL-----VAPLGPTVANPELFRKFGRGPEPW 65
Cdd:smart00349    1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLenysnLVSLGFQVPKPDLISQLEQGEEPW 60
DUF4371 pfam14291
Domain of unknown function (DUF4371);
503-707 9.11e-09

Domain of unknown function (DUF4371);


Pssm-ID: 405048  Cd Length: 236  Bit Score: 57.24  E-value: 9.11e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149773449   503 LVRGYTGPFKVETL---KYHEVSKAHRLCVNTVE---IKEDTPHTALVPEISSDLMAN---MEHFFNAAYSIAYHSRPL- 572
Cdd:pfam14291    4 LSTGFCSWNKADRLdqfVGHQVNSFHNIAKRKCEdlmRQGQSIKHILHKETDLEKNDYriwLKASIDIIIHLLHQGLPLr 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149773449   573 NDFEK-----------ILQLLQSTGTVI-----LGKyRNRTACTQFIK-----YISETLKREILEDVRNSPcVSVLLDSS 631
Cdd:pfam14291   84 GHDESeestnkglfveLLKYTAGQDEVVkkvlkNAP-KNNTYTSPPIQndivnCFSNEVTRSIIEEMDNDV-FGILVDET 161

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 149773449   632 TDASEQACVGIYIRYFKQM-EVKESYITLAPLYSETADGYFETIVSALDELDIPFRKpgwVVGLGTDG-SAMLSCRGG 707
Cdd:pfam14291  162 ADASDKEQMAIVFRYVDKYgVPIERFIGVIHVQETSSLSLKSAIDSLLKSLGISLKK---LRSQCYDGaSNMSGEFNG 236
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 11-41 1.45e-07

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 48.70  E-value: 1.45e-07
                          10        20        30
                  ....*....|....*....|....*....|.
gi 149773449   11 VTFDDITVYLLQEEWVLLSQQQKELCGSNKL 41
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVML 31
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 10-36 6.05e-07

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 47.08  E-value: 6.05e-07
                           10        20
                   ....*....|....*....|....*..
gi 149773449    10 PVTFDDITVYLLQEEWVLLSQQQKELC 36
Cdd:pfam01352    1 SVTFEDVAVDFTQEEWALLDPAQRNLY 27
Dimer_Tnp_hAT pfam05699
hAT family C-terminal dimerization region; This dimerization region is found at the C terminus ...
 990-1066 1.79e-05

hAT family C-terminal dimerization region; This dimerization region is found at the C terminus of the transposases of elements belonging to the Activator superfamily (hAT element superfamily). The isolated dimerization region forms extremely stable dimers in vitro.


Pssm-ID: 399013  Cd Length: 83  Bit Score: 44.17  E-value: 1.79e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149773449   990 LEEWLGLKTIAQHLPFSMLC---KNalaqHCRFPLLSKLMAVVVCVPISTSCCERGFKAMNRIRTDERTKLSNEVLNMLM 1066
Cdd:pfam05699    2 LDQYLSEPVLPRNEDFDPLEwwkEN----SSRYPNLSKLARDILSIPVSSAASERSFSTLGKVILESRNRLEPLNVEALL 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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