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Conserved domains on  [gi|197304729|ref|NP_001127874|]
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probable transmembrane reductase CYB561D1 isoform 3 [Homo sapiens]

Protein Classification

cytochrome b561 domain-containing protein( domain architecture ID 10171790)

cytochrome b561 domain-containing protein (CYB561D) similar to mammalian CYB561D2, also called transmembrane ascorbate ferrireductase, a two-heme-containing cytochrome that catalyzes ascorbate-dependent trans-membrane ferric-chelate reduction

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cyt_b561_CYB561D2_like cd08761
Eukaryotic cytochrome b(561), including the CYB561D2 gene product; Cytochrome b(561), as found ...
 4-155 6.95e-39

Eukaryotic cytochrome b(561), including the CYB561D2 gene product; Cytochrome b(561), as found in eukaryotes, similar to and including the human CYB561D2 gene product. CYB561D2 is a candidate tumor suppressor. The protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


:

Pssm-ID: 176491  Cd Length: 183  Bit Score: 130.49  E-value: 6.95e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197304729   4 LEFCLCMAEAILLFSPEHSLFFfCSRKARIRLHWAGQTLAILCAALGLGFIISSRTRSELPHLVSWHSWVGALTLLATAV 83
Cdd:cd08761   30 LGFLLLMTEALLLLQPTSSLTK-LARKTKVRLHWILQLLALLCILAGLVAIYYNKERNGKPHFTSWHGILGLVTVILIVL 108

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 197304729  84 QALCGLCLLCPRAAR--VSRVARLKLYHLTCGLVVYLMATVTVLLGMYSVWF-QAQIKGAAWYLCLALPVYPALV 155
Cdd:cd08761  109 QALGGLALLYPPGLRrgESKAKKLKKYHRLSGYVAYLLGLATLVLGLETRWFsKNVTHVALWYLALAVALALAGV 183
 
Name Accession Description Interval E-value
Cyt_b561_CYB561D2_like cd08761
Eukaryotic cytochrome b(561), including the CYB561D2 gene product; Cytochrome b(561), as found ...
 4-155 6.95e-39

Eukaryotic cytochrome b(561), including the CYB561D2 gene product; Cytochrome b(561), as found in eukaryotes, similar to and including the human CYB561D2 gene product. CYB561D2 is a candidate tumor suppressor. The protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176491  Cd Length: 183  Bit Score: 130.49  E-value: 6.95e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197304729   4 LEFCLCMAEAILLFSPEHSLFFfCSRKARIRLHWAGQTLAILCAALGLGFIISSRTRSELPHLVSWHSWVGALTLLATAV 83
Cdd:cd08761   30 LGFLLLMTEALLLLQPTSSLTK-LARKTKVRLHWILQLLALLCILAGLVAIYYNKERNGKPHFTSWHGILGLVTVILIVL 108

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 197304729  84 QALCGLCLLCPRAAR--VSRVARLKLYHLTCGLVVYLMATVTVLLGMYSVWF-QAQIKGAAWYLCLALPVYPALV 155
Cdd:cd08761  109 QALGGLALLYPPGLRrgESKAKKLKKYHRLSGYVAYLLGLATLVLGLETRWFsKNVTHVALWYLALAVALALAGV 183
Cytochrom_B561 pfam03188
Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport ...
 6-134 2.22e-35

Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport protein. It is an integral membrane protein, that binds two heme groups non-covalently. This is a eukaryotic family. Members of the 'prokaryotic cytochrome b561' family can be found in Pfam: PF01292.


Pssm-ID: 427188  Cd Length: 137  Bit Score: 120.40  E-value: 2.22e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197304729    6 FCLCMAEAILLFSpeHSLFFFCSRKARIRLHWAGQTLAILCAALGLGFIISSRTRSELPHLVSWHSWVGALTLLATAVQA 85
Cdd:pfam03188  10 FIFLMGEAILVYR--VNSTRRLSKKTKKLLHWILQALALILAVIGLVAVFKFHNLSGIPHFYSLHSWLGLLTVILYALQW 87

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 197304729   86 LCGLCLLCPRAARVSRVARLKLYHLTCGLVVYLMATVTVLLGM-YSVWFQ 134
Cdd:pfam03188  88 VGGFVTFLFPGLSKRIRPLLLPLHVFFGLVIFVLAIVTALLGLlEKLIFQ 137
B561 smart00665
Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate ...
 6-128 4.96e-27

Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the two heme groups being bound to conserved histidine residues. A cytochrome b-561 homologue, termed Dcytb, is an iron-regulated ferric reductase in the duodenal mucosa. Other homologues of these are also likely to be ferric reductases. SDR2 is proposed to be important in regulating the metabolism of iron in the onset of neurodegenerative disorders.


Pssm-ID: 214769  Cd Length: 129  Bit Score: 98.46  E-value: 4.96e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197304729     6 FCLCMAEAILLFspeHSLFFFCSRKARIRLHWAGQTLAILCAALGLGFIISSRTRSELPHLVSWHSWVGALTLLATAVQA 85
Cdd:smart00665  10 FGFLMGEAILVA---RPLTRFLSKPTWFLLHVVLQILALVLGVIGLLAIFISHNESGIANFYSLHSWLGLAAFVLAGLQW 86

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 197304729    86 LCGLCLLCPRAARVSRVARLKLYHLTCGLVVYLMATVTVLLGM 128
Cdd:smart00665  87 LSGFLRPLPPGLPSKYRSYLNPYHRFVGLAAFILAIVTIFLGL 129
 
Name Accession Description Interval E-value
Cyt_b561_CYB561D2_like cd08761
Eukaryotic cytochrome b(561), including the CYB561D2 gene product; Cytochrome b(561), as found ...
 4-155 6.95e-39

Eukaryotic cytochrome b(561), including the CYB561D2 gene product; Cytochrome b(561), as found in eukaryotes, similar to and including the human CYB561D2 gene product. CYB561D2 is a candidate tumor suppressor. The protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176491  Cd Length: 183  Bit Score: 130.49  E-value: 6.95e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197304729   4 LEFCLCMAEAILLFSPEHSLFFfCSRKARIRLHWAGQTLAILCAALGLGFIISSRTRSELPHLVSWHSWVGALTLLATAV 83
Cdd:cd08761   30 LGFLLLMTEALLLLQPTSSLTK-LARKTKVRLHWILQLLALLCILAGLVAIYYNKERNGKPHFTSWHGILGLVTVILIVL 108

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 197304729  84 QALCGLCLLCPRAAR--VSRVARLKLYHLTCGLVVYLMATVTVLLGMYSVWF-QAQIKGAAWYLCLALPVYPALV 155
Cdd:cd08761  109 QALGGLALLYPPGLRrgESKAKKLKKYHRLSGYVAYLLGLATLVLGLETRWFsKNVTHVALWYLALAVALALAGV 183
Cytochrom_B561 pfam03188
Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport ...
 6-134 2.22e-35

Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport protein. It is an integral membrane protein, that binds two heme groups non-covalently. This is a eukaryotic family. Members of the 'prokaryotic cytochrome b561' family can be found in Pfam: PF01292.


Pssm-ID: 427188  Cd Length: 137  Bit Score: 120.40  E-value: 2.22e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197304729    6 FCLCMAEAILLFSpeHSLFFFCSRKARIRLHWAGQTLAILCAALGLGFIISSRTRSELPHLVSWHSWVGALTLLATAVQA 85
Cdd:pfam03188  10 FIFLMGEAILVYR--VNSTRRLSKKTKKLLHWILQALALILAVIGLVAVFKFHNLSGIPHFYSLHSWLGLLTVILYALQW 87

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 197304729   86 LCGLCLLCPRAARVSRVARLKLYHLTCGLVVYLMATVTVLLGM-YSVWFQ 134
Cdd:pfam03188  88 VGGFVTFLFPGLSKRIRPLLLPLHVFFGLVIFVLAIVTALLGLlEKLIFQ 137
B561 smart00665
Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate ...
 6-128 4.96e-27

Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the two heme groups being bound to conserved histidine residues. A cytochrome b-561 homologue, termed Dcytb, is an iron-regulated ferric reductase in the duodenal mucosa. Other homologues of these are also likely to be ferric reductases. SDR2 is proposed to be important in regulating the metabolism of iron in the onset of neurodegenerative disorders.


Pssm-ID: 214769  Cd Length: 129  Bit Score: 98.46  E-value: 4.96e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197304729     6 FCLCMAEAILLFspeHSLFFFCSRKARIRLHWAGQTLAILCAALGLGFIISSRTRSELPHLVSWHSWVGALTLLATAVQA 85
Cdd:smart00665  10 FGFLMGEAILVA---RPLTRFLSKPTWFLLHVVLQILALVLGVIGLLAIFISHNESGIANFYSLHSWLGLAAFVLAGLQW 86

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 197304729    86 LCGLCLLCPRAARVSRVARLKLYHLTCGLVVYLMATVTVLLGM 128
Cdd:smart00665  87 LSGFLRPLPPGLPSKYRSYLNPYHRFVGLAAFILAIVTIFLGL 129
Cyt_b561 cd08554
Eukaryotic cytochrome b(561); Cytochrome b(561) is a family of endosomal or secretory ...
 6-128 2.10e-17

Eukaryotic cytochrome b(561); Cytochrome b(561) is a family of endosomal or secretory vesicle-specific electron transport proteins. They are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments. This is an exclusively eukaryotic family. Members of the prokaryotic cytochrome b561 family are not deemed homologous.


Pssm-ID: 176489  Cd Length: 131  Bit Score: 73.86  E-value: 2.10e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197304729   6 FCLCMAEAILlfspEHSLFFFCSRKARIRLHWAGQTLAILCAALGLGFIISSRTRSELPHLVSWHSWVGALTLLATAVQA 85
Cdd:cd08554   13 FVFLMGEALL----VYRVFRLLTKRALKLLHAILHLLAFVLGLVGLLAVFLFHNAGGIANLYSLHSWLGLATVLLFLLQF 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 197304729  86 LCGLCLLCPRAARVSRVARLKLYHLTCGLVVYLMATVTVLLGM 128
Cdd:cd08554   89 LSGFVLFLLPLLRLSYRSSLLPFHRFFGLAIFVLAIATILLGI 131
Cyt_b561_CG1275_like cd08764
Non-vertebrate eumetazoan cytochrome b(561); Cytochrome b(561), as found in non-vertebrate ...
 28-128 2.78e-07

Non-vertebrate eumetazoan cytochrome b(561); Cytochrome b(561), as found in non-vertebrate eumetazoans, similar to the Drosophila melanogaster CG1275 gene product. This protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176494  Cd Length: 214  Bit Score: 48.48  E-value: 2.78e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197304729  28 SRKARIR-LHWAGQTLAILCAALGLGFIISSRT--RSELPHLVSWHSWVGALTLLATAVQALCGLC-LLCPRAARVSRVA 103
Cdd:cd08764   52 TRKKRLKlLHAVLHLLAFILAVIGLKAVFDSHNlaKPPIPNMYSLHSWLGLTAVILFSLQWVGGFVsFLFPGLPETLRAA 131

                         90       100
                 ....*....|....*....|....*
gi 197304729 104 RLKLyHLTCGLVVYLMATVTVLLGM 128
Cdd:cd08764  132 YLPL-HVFFGLFIFVLAVATALLGI 155
Cyt_b561_FRRS1_like cd08760
Eukaryotic cytochrome b(561), including the FRRS1 gene product; Cytochrome b(561), as found in ...
 24-129 7.37e-07

Eukaryotic cytochrome b(561), including the FRRS1 gene product; Cytochrome b(561), as found in eukaryotes, similar to and including the human FRRS1 gene product (ferric-chelate reductase 1), also called SDR-2 (stromal cell-derived receptor 2). This family comprises a variety of domain architectures, many of which contain dopamine beta-monooxygenase (DOMON) domains. The protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176490  Cd Length: 191  Bit Score: 46.95  E-value: 7.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197304729  24 FFFCSRKARIRLHWAGQTLAILCAALGLGFIISSRTRSELpHLVSWHSWVGALTLLATAVQALCGLcLLCPRAARVSRVa 103
Cdd:cd08760   60 YFLLGDPVWFYLHAGLQLLAVLLAIAGFVLGIVLVQGGGG-SLNNAHAILGIIVLALAILQPLLGL-LRPHPGSKKRSI- 136

                         90       100
                 ....*....|....*....|....*.
gi 197304729 104 rLKLYHLTCGLVVYLMATVTVLLGMY 129
Cdd:cd08760  137 -WNWAHRWLGRAALILAIVNIFLGLD 161
Cyt_b561_ACYB-1_like cd08766
Plant cytochrome b(561), including the carbon monoxide oxygenase ACYB-1; Cytochrome b(561), as ...
 6-128 1.80e-06

Plant cytochrome b(561), including the carbon monoxide oxygenase ACYB-1; Cytochrome b(561), as found in plants, similar to the Arabidopsis thaliana ACYB-1 gene product, a cytochrome b561 isoform localized to the tonoplast. This protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), and might be capable of trans-membrane electron transport from intracellular ascorbate to extracellular ferric chelates. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176496  Cd Length: 144  Bit Score: 45.38  E-value: 1.80e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197304729   6 FCLCMAEAILLFSpehslFFFCSRKARIRLHWAGQTLAILCAALGLGFIISSRTRSELPHLVSWHSWVGALTLLATAVQA 85
Cdd:cd08766   19 FIFLAGEAILAYK-----TVPGSREVQKAVHLTLHLVALVLGIVGIYAAFKFHNEVGIPNLYSLHSWLGIGTISLFGLQW 93

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 197304729  86 LCG-LCLLCPRAARVSRvARLKLYHLTCGLVVYLMATVTVLLGM 128
Cdd:cd08766   94 LFGfVTFWFPGASRNTR-AALLPWHVFLGLAIYYLAIATAETGL 136
Cyt_b561_CYB561 cd08763
Vertebrate cytochrome b(561), CYB561 gene product; Cytochrome b(561), as found in vertebrates, ...
 8-128 4.06e-04

Vertebrate cytochrome b(561), CYB561 gene product; Cytochrome b(561), as found in vertebrates, which might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176493  Cd Length: 143  Bit Score: 38.64  E-value: 4.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197304729   8 LCMAEAILLFSPEHSLFFFCSRKARIR----LHWAGQTLAILCAALGLGFIISSRTRSELPHLVSWHSWVGALTLLATAV 83
Cdd:cd08763   12 LCMVLGLVFLCGEALLVYRVFRNETKRstkiLHGLLHIMALVISLVGLVAVFDYHQANGYPDMYSLHSWCGILTFVLYFL 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 197304729  84 QALCGLCLLCPRAARVSRVARLKLYHLTCGLVVYLMATVTVLLGM 128
Cdd:cd08763   92 QWLIGFSFFLFPGASFTLRSQYKPLHEFFGRALFLSSVGTSLLGL 136
Cyt_b561_CYBRD1 cd08765
Vertebrate cytochrome b(561), CYBRD1 gene product; Duodenal cytochrome b or ferric-chelate ...
 27-128 5.45e-03

Vertebrate cytochrome b(561), CYBRD1 gene product; Duodenal cytochrome b or ferric-chelate reductase 3, a cytochrome b(561), as found in vertebrates, which might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. This protein is expressed at the brush border of duodenal enterocytes and may play a role in the uptake of dietary Fe(3+), facilitating its transport into the mucosal cells. It may also be involved in the recycling of extracellular ascorbate in erythrocyte membranes, and act as a ferrireductase in epithelial cells of the respiratory system. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176495  Cd Length: 153  Bit Score: 35.64  E-value: 5.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197304729  27 CSRKARIRLHWAGQTLAILCAALGLGFIISSRTRSELPHLVSWHSWVGALTLLATAVQALCGLCLLCPRAARVSRVARLK 106
Cdd:cd08765   42 CSKLLMKLIHAGLHILAFILAIISVVAVFVFHNAKNIPNMYSLHSWVGLAAVILYPLQLVLGISVYLLPVAPVRLRAALM 121

                         90       100
                 ....*....|....*....|..
gi 197304729 107 LYHLTCGLVVYLMATVTVLLGM 128
Cdd:cd08765  122 PLHVYSGLFIFGTVIATALMGI 143
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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