NCBI Conserved Domain Search

Conserved domains on [gi|240120077|ref|NP_001155294|]

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regulator of G-protein signaling 17 isoform 1 [Mus musculus]

Protein Classification

regulator of G-protein signaling domain-containing protein( domain architecture ID 446)

regulator of G-protein signaling (RGS) domain-containing protein belongs to a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs)

CATH: 1.10.167.10

PubMed: 10203790|10836135|8774882

SCOP: 4001125

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

RGS super family

cl02565

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part ...

61-217

3.33e-84

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.

The actual alignment was detected with superfamily member cd08746:

Pssm-ID: 470619 [Multi-domain] Cd Length: 167 Bit Score: 247.59 E-value: 3.33e-84

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120077  61 LTVRNEERGDSSGRSPHTTKMESIQVLEECQNPTADEVLSWSQNFDKMMKTPAGRNLFREFLRTEYSEENLLFWLACEDL 140
Cdd:cd08746   10 CLTVRNQEDERNRRTSYEFRAEGIPNCEESPKPTLEEVCAWGQSFDKLMLTPAGRNAFREFLRTEFSEENMLFWMACEEL 89

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 240120077 141 KKEQNKKAVEEKARMIYEDYISILSPKEVSLDSRVREVINRSLLDPSPHMYEDAQLQIYTLMHRDSFPRFLNSQIYK 217
Cdd:cd08746   90 KKEANKSVIEEKARIIYEDYISILSPKEVSLDSRVREVINRNMLEPSQHTFDDAQLQIYTLMHRDSYPRFMNSAIYK 166

Name

Accession

Description

Interval

E-value

RGS_RGS20

cd08746

Regulator of G protein signaling (RGS) domain found in the RGS20 protein; The RGS (Regulator ...

61-217

3.33e-84

Regulator of G protein signaling (RGS) domain found in the RGS20 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS20 protein (also known as RGSZ1), a member of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling is controlled by the RGS domain, which accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP resulting in reassociation of the alpha-subunit with the beta-gamma-dimer and inhibition of downstream activity. As a major G-protein regulator, the RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The RZ subfamily of RGS proteins include RGS17, RGS19 (former GAIP), and the splice variant of RGS20, Ret-RGS. RGS20 is expressed exclusively in brain, with the highest concentrations in the temporal lobe and the caudate nucleus and may play a role in signaling regulation in these brain regions. RGS20 acts as a GAP of both G-alpha-z and G-alpha-I and controls signaling in the mu opioid receptor pathway.

Pssm-ID: 188700 [Multi-domain] Cd Length: 167 Bit Score: 247.59 E-value: 3.33e-84

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120077  61 LTVRNEERGDSSGRSPHTTKMESIQVLEECQNPTADEVLSWSQNFDKMMKTPAGRNLFREFLRTEYSEENLLFWLACEDL 140
Cdd:cd08746   10 CLTVRNQEDERNRRTSYEFRAEGIPNCEESPKPTLEEVCAWGQSFDKLMLTPAGRNAFREFLRTEFSEENMLFWMACEEL 89

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 240120077 141 KKEQNKKAVEEKARMIYEDYISILSPKEVSLDSRVREVINRSLLDPSPHMYEDAQLQIYTLMHRDSFPRFLNSQIYK 217
Cdd:cd08746   90 KKEANKSVIEEKARIIYEDYISILSPKEVSLDSRVREVINRNMLEPSQHTFDDAQLQIYTLMHRDSYPRFMNSAIYK 166

RGS

pfam00615

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for ...

104-219

7.38e-43

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.

Pssm-ID: 459870 Cd Length: 117 Bit Score: 140.83 E-value: 7.38e-43

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120077  104 NFDKMMKTPAGRNLFREFLRTEYSEENLLFWLACEDLKKEQNKKAVEEKARMIYEDYISILSPKEVSLDSRVREVINRSL 183
Cdd:pfam00615   1 SFDSLLEDQPGRRLFRQFLESEFSEENLEFWLACEEFKKADPDEERLKKAKEIYNEFLAPGSPKEINLDSDLREEIRENL 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 240120077  184 LD-PSPHMYEDAQLQIYTLMHRDSFPRFLNSQIYKAF 219
Cdd:pfam00615  81 EKePTRDLFDEAQAEVYELMEKDSYPRFLKSPLYLRL 117

RGS

smart00315

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...

104-219

1.57e-42

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.

Pssm-ID: 214613 Cd Length: 118 Bit Score: 140.10 E-value: 1.57e-42

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120077   104 NFDKMMKTPAGRNLFREFLRTEYSEENLLFWLACEDLKKEQNKKAVEEKARMIYEDYISILSPKEVSLDSRVREVINRSL 183
Cdd:smart00315   1 SLESLLSDPIGRLLFREFLESEFSEENLEFWLAVEEFKKAEDDEERIAKAREIYDKFLSPNAPKEVNLDSDLREKIEENL 80

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 240120077   184 LD--PSPHMYEDAQLQIYTLMHRDSFPRFLNSQIYKAF 219
Cdd:smart00315  81 ESeePPPDLFDEAQREVYELLEKDSFPRFLESDYYLRF 118

Name

Accession

Description

Interval

E-value

RGS_RGS20

cd08746

Regulator of G protein signaling (RGS) domain found in the RGS20 protein; The RGS (Regulator ...

61-217

3.33e-84

Pssm-ID: 188700 [Multi-domain] Cd Length: 167 Bit Score: 247.59 E-value: 3.33e-84

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120077  61 LTVRNEERGDSSGRSPHTTKMESIQVLEECQNPTADEVLSWSQNFDKMMKTPAGRNLFREFLRTEYSEENLLFWLACEDL 140
Cdd:cd08746   10 CLTVRNQEDERNRRTSYEFRAEGIPNCEESPKPTLEEVCAWGQSFDKLMLTPAGRNAFREFLRTEFSEENMLFWMACEEL 89

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 240120077 141 KKEQNKKAVEEKARMIYEDYISILSPKEVSLDSRVREVINRSLLDPSPHMYEDAQLQIYTLMHRDSFPRFLNSQIYK 217
Cdd:cd08746   90 KKEANKSVIEEKARIIYEDYISILSPKEVSLDSRVREVINRNMLEPSQHTFDDAQLQIYTLMHRDSYPRFMNSAIYK 166

RGS_RZ-like

cd08718

Regulator of G protein signaling (RGS) domain found in the RZ protein; The RGS (Regulator of ...

101-218

4.02e-82

Regulator of G protein signaling (RGS) domain found in the RZ protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling is controlled by RGS domains, which accelerate GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in reassociation of the alpha-subunit with the beta-gamma-dimer and inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The RZ subfamily of RGS proteins includes RGS17, RGS19 (former GAIP), RGS20, and its splice variant Ret-RGS.

Pssm-ID: 188673 Cd Length: 118 Bit Score: 240.44 E-value: 4.02e-82

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120077 101 WSQNFDKMMKTPAGRNLFREFLRTEYSEENLLFWLACEDLKKEQNKKAVEEKARMIYEDYISILSPKEVSLDSRVREVIN 180
Cdd:cd08718    1 WAQSFDKLMKSPAGRNVFREFLRTEYSEENMLFWLACEELKKEANKHVIEEKARLIYEDYISILSPKEVSLDSRVREVIN 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 240120077 181 RSLLDPSPHMYEDAQLQIYTLMHRDSFPRFLNSQIYKA 218
Cdd:cd08718   81 RNMLEPSPHTFDDAQLQIYTLMHRDSYPRFLNSAIYKS 118

RGS_RGS19

cd08745

Regulator of G protein signaling (RGS) domain found in the RGS19 protein; The RGS (Regulator ...

101-218

2.92e-77

Regulator of G protein signaling (RGS) domain found in the RGS19 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS19 protein (also known as GAIP), a member of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling is controlled by RGS domains, which accelerate GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, resulting in a reassociation of the alpha-subunit with the beta-gamma-dimer and an inhibition of downstream activity. As a major G-protein regulator, the RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The RZ subfamily of RGS proteins includes RGS17, RGS20, and its splice variant Ret-RGS. RGS19 participates in regulation of dopamine receptor D2R and D3R, as well as beta-adrenergic receptors .

Pssm-ID: 188699 Cd Length: 118 Bit Score: 228.40 E-value: 2.92e-77

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120077 101 WSQNFDKMMKTPAGRNLFREFLRTEYSEENLLFWLACEDLKKEQNKKAVEEKARMIYEDYISILSPKEVSLDSRVREVIN 180
Cdd:cd08745    1 WAQSFDKLMKSPAGRNVFREFLRTEYSEENMLFWLACEELKAEANKHVIDEKARLIYEDYISILSPKEVSLDSRVREGIN 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 240120077 181 RSLLDPSPHMYEDAQLQIYTLMHRDSFPRFLNSQIYKA 218
Cdd:cd08745   81 RKMQEPSSHTFDDAQLQIYTLMHRDSYPRFLNSPIYKA 118

RGS_RGS17

cd08744

Regulator of G protein signaling (RGS) domain found in the RGS17 protein; The RGS (Regulator ...

101-218

1.16e-75

Regulator of G protein signaling (RGS) domain found in the RGS17 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS17 protein, a member of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, the RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of the G-protein signaling controlled by the RGS domain, which accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, results in reassociation of the alpha-subunit with the beta-gamma-dimer and inhibition of downstream activity. The RZ subfamily of RGS proteins includes RGS19 (former GAIP), RGS20, and its splice variant Ret-RGS. RGS17 is a relatively non-selective GAP for G-alpha-z and other G-alpha-i/o proteins. RGS17 blocks dopamine receptor-mediated inhibition of cAMP accumulation; it also blocks thyrotropin releasing hormone-stimulated Ca++ mobilization. RGS17, like other members of RZ subfamily, can act either as a GAP or as G-protein effector antogonist.

Pssm-ID: 188698 Cd Length: 118 Bit Score: 224.22 E-value: 1.16e-75

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120077 101 WSQNFDKMMKTPAGRNLFREFLRTEYSEENLLFWLACEDLKKEQNKKAVEEKARMIYEDYISILSPKEVSLDSRVREVIN 180
Cdd:cd08744    1 WSQNFDKMMKTPAGRNLFREFLRTEYSEENLLFWLACEDLKKEQNKKVIEEKARLIYEDYISILSPKEVSLDSRVREVIN 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 240120077 181 RSLLDPSPHMYEDAQLQIYTLMHRDSFPRFLNSQIYKA 218
Cdd:cd08744   81 RNLLDPNPHMYEDAQLQIYTLMHRDSFPRFLNSQIYKS 118

RGS

pfam00615

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for ...

104-219

7.38e-43

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.

Pssm-ID: 459870 Cd Length: 117 Bit Score: 140.83 E-value: 7.38e-43

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120077  104 NFDKMMKTPAGRNLFREFLRTEYSEENLLFWLACEDLKKEQNKKAVEEKARMIYEDYISILSPKEVSLDSRVREVINRSL 183
Cdd:pfam00615   1 SFDSLLEDQPGRRLFRQFLESEFSEENLEFWLACEEFKKADPDEERLKKAKEIYNEFLAPGSPKEINLDSDLREEIRENL 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 240120077  184 LD-PSPHMYEDAQLQIYTLMHRDSFPRFLNSQIYKAF 219
Cdd:pfam00615  81 EKePTRDLFDEAQAEVYELMEKDSYPRFLKSPLYLRL 117

RGS

smart00315

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...

104-219

1.57e-42

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.

Pssm-ID: 214613 Cd Length: 118 Bit Score: 140.10 E-value: 1.57e-42

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120077   104 NFDKMMKTPAGRNLFREFLRTEYSEENLLFWLACEDLKKEQNKKAVEEKARMIYEDYISILSPKEVSLDSRVREVINRSL 183
Cdd:smart00315   1 SLESLLSDPIGRLLFREFLESEFSEENLEFWLAVEEFKKAEDDEERIAKAREIYDKFLSPNAPKEVNLDSDLREKIEENL 80

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 240120077   184 LD--PSPHMYEDAQLQIYTLMHRDSFPRFLNSQIYKAF 219
Cdd:smart00315  81 ESeePPPDLFDEAQREVYELLEKDSFPRFLESDYYLRF 118

RGS_R7-like

cd08705

Regulator of G protein signaling (RGS) domain found in the R7 subfamily of proteins; The RGS ...

101-218

4.64e-38

Regulator of G protein signaling (RGS) domain found in the R7 subfamily of proteins; The RGS (Regulator of G-protein Signaling) domain is an essential part of the R7 (Neuronal RGS) protein subfamily of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The R7 subfamily includes RGS6, RGS7, RGS9, and RGS11, all of which, in humans, are expressed predominantly in the nervous system, form an obligatory complex with G-beta-5, and play important roles in the regulation of crucial neuronal processes. In addition, R7 proteins were found to bind many other proteins outside of the G protein signaling pathways including: m-opioid receptor, beta-arrestin, alpha-actinin-2, NMDAR, polycystin, spinophilin, guanylyl cyclase, among others.

Pssm-ID: 188660 Cd Length: 121 Bit Score: 128.51 E-value: 4.64e-38

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120077 101 WSQNFDKMMKTPAGRNLFREFLRTEYSEENLLFWLACEDLKKEQNKKaVEEKARMIYEDYISILSPKEVSLDSRVREVIN 180
Cdd:cd08705    5 WGFSFSELLKDPVGREQFLKFLEKEFSGENLRFWEACQDLKYGPQSQ-VPEKVQEIYQEFLAPGAPSWINIDSKTMEITL 83

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 240120077 181 RSLLDPSPHMYEDAQLQIYTLMHRDSFPRFLNSQIYKA 218
Cdd:cd08705   84 KNLKDPHRYTFDAAQEHIYMLMKKDSYPRFLRSDIYKE 121

RGS_RGS3

cd08713

Regulator of G protein signaling (RGS) domain found in the RGS3 protein; The RGS (Regulator of ...

106-216

1.91e-37

Regulator of G protein signaling (RGS) domain found in the RGS3 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS3 protein. RGS3 is a member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes. RGS3 induces apoptosis when overexpressed and is involved in cell migration through interaction with the Ephrin receptor. RGS3 exits as several splice isoforms and interacts with neuroligin, estrogen receptor-alpha, and 14-3-3 outside of the GPCR pathways.

Pssm-ID: 188668 Cd Length: 114 Bit Score: 126.91 E-value: 1.91e-37

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120077 106 DKMMKTPAGRNLFREFLRTEYSEENLLFWLACEDLKKEQNKKAVEEKARMIYEDYISILSPKEVSLDSRVREVINRSLLD 185
Cdd:cd08713    2 EKLLLHKYGLAVFRAFLQTEFSEENLEFWLACEEYKKIKSQSKMASRAKKIFAEYIAIQSCKEVNLDSYTREHTKENLQN 81

                         90       100       110
                 ....*....|....*....|....*....|.
gi 240120077 186 PSPHMYEDAQLQIYTLMHRDSFPRFLNSQIY 216
Cdd:cd08713   82 PTRGCFDLAQKRIYGLMEKDSYPRFLRSDLY 112

RGS_R12-like

cd08706

Regulator of G protein signaling (RGS) domain found in the R12 subfamily of proteins; The RGS ...

105-217

2.61e-36

Regulator of G protein signaling (RGS) domain found in the R12 subfamily of proteins; The RGS (Regulator of G-protein Signaling) domain is an essential part of the R12 (Neuronal RGS) protein subfamily of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play a critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling, controlled by RGS domain, accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP that results in reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The R12 RGS subfamily includes RGS10, RGS12 and RGS14 all of which are highly selective for G-alpha-i1 over G-alpha-q.

Pssm-ID: 188661 Cd Length: 113 Bit Score: 123.97 E-value: 2.61e-36

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120077 105 FDKMMKTPAGRNLFREFLRTEYSEENLLFWLACEDLKKEQNKKAVEEKARMIYEDYISILSPKEVSLDSRVReVINRSLL 184
Cdd:cd08706    1 FERLLQDPVGVKYFTEFLKKEFSEENILFWQACEKFKKIPDKKQLVQEAREIYDTFLSSKASSPVNIDSQAQ-LAEEMLE 79

                         90       100       110
                 ....*....|....*....|....*....|...
gi 240120077 185 DPSPHMYEDAQLQIYTLMHRDSFPRFLNSQIYK 217
Cdd:cd08706   80 EPHPDMFQKQQLQIFNLMKFDSYSRFLKSPLYQ 112

RGS

cd07440

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part ...

109-217

1.99e-35

Pssm-ID: 188659 [Multi-domain] Cd Length: 113 Bit Score: 121.73 E-value: 1.99e-35

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120077 109 MKTPAGRNLFREFLRTEYSEENLLFWLACEDLKKEQNKK-AVEEKARMIYEDYISILSPKEVSLDSRVREVINRSLL--D 185
Cdd:cd07440    1 LRDPYGLEYFRQFLKSEHCEENLEFWLAVEKFKKTTSSDeELKSKAKEIYDKYISKDAPKEINIPESIREEIEENLEepY 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 240120077 186 PSPHMYEDAQLQIYTLMHRDSFPRFLNSQIYK 217
Cdd:cd07440   81 PDPDCFDEAQEHILNLLEKDSYPRFLKSDLYL 112

RGS_RGS21

cd08723

Regulator of G protein signaling (RGS) domain found in the RGS21 protein; The RGS (Regulator ...

108-217

4.45e-35

Regulator of G protein signaling (RGS) domain found in the RGS21 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part RGS21 protein, a member of RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, apoptosis, and cell proliferation, as well as modulation of cardiac development. RGS21 is a member of the R4/RGS subfamily and its mRNA was detected only in sensory taste cells that express sweet taste receptors and the taste G-alpha subunit, gustducin, suggesting a potential role in regulating taste transduction.

Pssm-ID: 188678 Cd Length: 111 Bit Score: 120.93 E-value: 4.45e-35

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120077 108 MMKTPAGRNLFREFLRTEYSEENLLFWLACEDLKKEQNKKAVEEKARMIYEDYISILSPKEVSLDSRVREVINRSLLDPS 187
Cdd:cd08723    1 LLANQAGLDAFRTFLKSEFSEENVEFWLACEDFKKTKSSTEIALKAQMIYSEFIQADAPKEINIDFHTRDLISQNISEPT 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 240120077 188 PHMYEDAQLQIYTLMHRDSFPRFLNSQIYK 217
Cdd:cd08723   81 LKCFDEAQSLIYCLMAKDSFPRFLKSEVYK 110

RGS_RGS5

cd08717

Regulator of G protein signaling (RGS) domain found in the RGS5 protein; The RGS (Regulator of ...

105-217

5.67e-35

Regulator of G protein signaling (RGS) domain found in the RGS5 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS5 protein. RGS5 is member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. Two splice isoforms of RGS5 has been found: RGS5L (long) which is expressed in smooth muscle cells (pericytes) and heart and RGS5S (short) which is highly expressed in the ciliary body of the eye, kidney, brain, spleen, skeletal muscle, and small intestine. Outside of the GPCR pathway, RGS5 interacts with the 14-3-3 protein.

Pssm-ID: 188672 Cd Length: 114 Bit Score: 120.48 E-value: 5.67e-35

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120077 105 FDKMMKTPAGRNLFREFLRTEYSEENLLFWLACEDLKKEQNKKAVEEKARMIYEDYISILSPKEVSLDSRVREVINRSLL 184
Cdd:cd08717    1 LDKLLQNSYGLASFKSFLKSEFSEENIEFWEACEDYKKTKSPLKMATKAKKIYEEFIQTEAPKEVNIDHFTKDVTMKNLV 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 240120077 185 DPSPHMYEDAQLQIYTLMHRDSFPRFLNSQIYK 217
Cdd:cd08717   81 EPSSSSFDLAQKRIFALMEKDSLPRFVRSEFYQ 113

RGS_RGS18

cd08712

Regulator of G protein signaling (RGS) domain found in the RGS18 protein; The RGS (Regulator ...

105-216

9.09e-35

Regulator of G protein signaling (RGS) domain found in the RGS18 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS18 protein. RGS18 is a member of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS18 is a member of the R4/RGS subfamily and is expressed predominantly in osteoclasts where it acts as a negative regulator of the acidosis-induced osteoclastogenic OGR1/NFAT signaling pathway. RANKL (receptor activator of nuclear factor B ligand) stimulates osteoclastogenesis by inhibiting expression of RGS18.

Pssm-ID: 188667 Cd Length: 114 Bit Score: 120.04 E-value: 9.09e-35

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120077 105 FDKMMKTPAGRNLFREFLRTEYSEENLLFWLACEDLKKEQNKKAVEEKARMIYEDYISILSPKEVSLDSRVREVINRSLL 184
Cdd:cd08712    1 FDKLLSHKDGLEAFTRFLKTEFSEENIEFWIACEDYKKSKTPQQIHLKAKAIYEKFIQTDAPKEVNLDFHTKEVTTNSIE 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 240120077 185 DPSPHMYEDAQLQIYTLMHRDSFPRFLNSQIY 216
Cdd:cd08712   81 QPTLTSFDAAQSRVYQLMEQDSYPRFLKSDIY 112

RGS_RGS1

cd08715

Regulator of G protein signaling (RGS) domain found in the RGS1 protein; The RGS (Regulator of ...

105-216

3.60e-32

Regulator of G protein signaling (RGS) domain found in the RGS1 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS1 protein. RGS1 is a member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS 1 is expressed predominantly in hematopoietic compartments, including T and B lymphocytes, and may play a major role in chemokine-mediated homing of lymphocytes to secondary lymphoid organs. In addition, RGS1 interacts with calmodulin and 14-3-3 protein outside of the GPCR pathway.

Pssm-ID: 188670 Cd Length: 114 Bit Score: 113.51 E-value: 3.60e-32

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120077 105 FDKMMKTPAGRNLFREFLRTEYSEENLLFWLACEDLKKeQNKKAVEEKARMIYEDYISILSPKEVSLDSRVREVINRSLL 184
Cdd:cd08715    1 LEKLLASQTGQNVFRSFLKSEFSEENIEFWLACEDYKK-TESDLLPCKAEEIYKEFVQSDAAKQINIDFRTRESTAKKIK 79

                         90       100       110
                 ....*....|....*....|....*....|..
gi 240120077 185 DPSPHMYEDAQLQIYTLMHRDSFPRFLNSQIY 216
Cdd:cd08715   80 APTPTCFDEAQKVIYILMERDSYPRFLKSDIY 111

RGS_RGS8

cd08711

Regulator of G protein signaling (RGS) domain found in the RGS8 protein; The RGS (Regulator of ...

94-216

3.67e-32

Regulator of G protein signaling (RGS) domain found in the RGS8 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS8 protein. RGS8 is a member of R4/RGS subfamily of RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS8 is involved in G-protein-gated potassium channels regulation and predominantly expressed in the brain. RGS8 also is selectively expressed in the hematopoietic system (NK cells).

Pssm-ID: 188666 Cd Length: 125 Bit Score: 113.68 E-value: 3.67e-32

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120077  94 TADEVLSWSQNFDKMMKTPAGRNLFREFLRTEYSEENLLFWLACEDLKKEQNKKAVEEKARMIYEDYISILSPKEVSLDS 173
Cdd:cd08711    1 STEEATRWADSFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLVSKAHRIFEEFVDVQAPREVNIDF 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 240120077 174 RVREVINRSLLDPSPHMYEDAQLQIYTLMHRDSFPRFLNSQIY 216
Cdd:cd08711   81 QTREATRKNLQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMY 123

RGS_RGS2

cd08709

Regulator of G protein signaling (RGS) domain found in the RGS2 protein; The RGS (Regulator of ...

105-217

1.17e-31

Regulator of G protein signaling (RGS) domain found in the RGS2 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS2 protein. RGS2 is a member of R4/RGS subfamily of RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G- alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS2 plays important roles in the regulation of blood pressure and the pathogenesis of human hypertension, as well as in bone formation in osteoblasts. Outside of the GPCR pathway RGS2 interacts with calmodulin, beta- COP, tubulin, PKG1-alpha, and TRPV6.

Pssm-ID: 188664 Cd Length: 114 Bit Score: 112.07 E-value: 1.17e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120077 105 FDKMMKTPAGRNLFREFLRTEYSEENLLFWLACEDLKKEQNKKAVEEKARMIYEDYISILSPKEVSLDSRVREVINRSLL 184
Cdd:cd08709    1 FDELLASKYGVAAFRAFLKSEFSEENIEFWLACEDFKKTKSPQKLTSKAKKIYTDFIEKEAPKEINIDFQTKTLIAQNIQ 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 240120077 185 DPSPHMYEDAQLQIYTLMHRDSFPRFLNSQIYK 217
Cdd:cd08709   81 EATSGCFTAAQKRVYSLMENNSYPRFLESEFYQ 113

RGS_RGS4

cd08714

Regulator of G protein signaling (RGS) domain found in the RGS4 protein; The RGS (Regulator of ...

105-216

2.52e-31

Regulator of G protein signaling (RGS) domain found in the RGS4 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS4 protein. RGS4 is a member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. RGS4 is expressed widely in brain including prefrontal cortex, striatum, locus coeruleus (LC), and hippocampus and has been implicated in regulation of opioid, cholinergic, and serotonergic signaling. Dysfunctions in RGS4 proteins are involved in etiology of Parkinson's disease, addiction, and schizophrenia. RGS4 also is up-regulated in the failing human heart. RGS4 interacts with many binding partners outside of GPCR pathways, including calmodulin, COP, Kir3, PIP, calcium/CaM, PA, ErbB3, and 14-3-3.

Pssm-ID: 188669 Cd Length: 114 Bit Score: 111.13 E-value: 2.52e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120077 105 FDKMMKTPAGRNLFREFLRTEYSEENLLFWLACEDLKKEQNKKAVEEKARMIYEDYISILSPKEVSLDSRVREVINRSLL 184
Cdd:cd08714    1 LENLINHECGLAAFKAFLKSEYSEENIDFWVSCEDYKKTKSPSKLSPKARKIYEEFISVQATKEVNLDSCTREETSRNML 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 240120077 185 DPSPHMYEDAQLQIYTLMHRDSFPRFLNSQIY 216
Cdd:cd08714   81 EPTISCFDEAQKKIFTLMEKDSYRRFLKSRFY 112

RGS_RGS16

cd08710

Regulator of G protein signaling (RGS) domain found in the RGS16 protein; The RGS (Regulator ...

105-217

5.43e-30

Regulator of G protein signaling (RGS) domain found in the RGS16 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS16 protein. RGS16 is a member of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS16 is a member of the R4/RGS subfamily and interacts with neuronal G-alpha0. RGS16 expression is upregulated by IL-17 of the NF-kappaB signaling pathway in autoimmune B cells.

Pssm-ID: 188665 Cd Length: 114 Bit Score: 107.85 E-value: 5.43e-30

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120077 105 FDKMMKTPAGRNLFREFLRTEYSEENLLFWLACEDLKKEQNKKAVEEKARMIYEDYISILSPKEVSLDSRVREVINRSLL 184
Cdd:cd08710    1 FDLLLNSKNGVAAFHAFLKTEFSEENLEFWLACEEFKKIRSATKLASRAHHIFEEFIRSEAPKEVNIDHETRELTRTNLQ 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 240120077 185 DPSPHMYEDAQLQIYTLMHRDSFPRFLNSQIYK 217
Cdd:cd08710   81 AATTSCFDVAQGKTRTLMEKDSYPRFLKSPAYR 113

RGS_RGS13

cd08716

Regulator of G protein signaling (RGS) domain found in the RGS13 protein; The RGS (Regulator ...

105-217

1.94e-29

Regulator of G protein signaling (RGS) domain found in the RGS13 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS13 protein. RGS13 is member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS13 is predominantly expressed in T and B lymphocytes and in mast cells, and plays a role in adaptive immune responses. RGS13 also found in Rgs13, which is also expressed in dendritic cells and in neuroendocrine cells of the thymus, gastrointestinal, and respiratory tracts. Outside of the GPCR pathway, RGS5 interacts with the PIP3 protein.

Pssm-ID: 188671 Cd Length: 114 Bit Score: 106.16 E-value: 1.94e-29

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120077 105 FDKMMKTPAGRNLFREFLRTEYSEENLLFWLACEDLKKEQNKKAVEEKARMIYEDYISILSPKEVSLDSRVREVINRSLL 184
Cdd:cd08716    1 FENLMATKYGPIIYATYLKTEHSDENIEFWLACETYKKIASQRKRISMARKLFASYIQPQAPREINIDSPTRKAIIRNIQ 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 240120077 185 DPSPHMYEDAQLQIYTLMHRDSFPRFLNSQIYK 217
Cdd:cd08716   81 EPTQSCFDEAQRIVYMHMERDSYPRFLESKFYQ 113

RGS_RGS6

cd08737

Regulator of G protein signaling (RGS) domain found in the RGS6 protein; The RGS (Regulator of ...

98-217

3.12e-29

Regulator of G protein signaling (RGS) domain found in the RGS6 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS6 protein, a member of R7 subfamily of the RGS protein family. RGS is a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). Other members of the R7 subfamily (Neuronal RGS) include: RGS7, RGS9, and RGS11, all of which are expressed predominantly in the nervous system, form an obligatory complex with G-beta-5, and play important roles in the regulation of crucial neuronal processes such as vision and motor control. Additionally they have been implicated in many neurological conditions such as anxiety, schizophrenia, and drug dependence. RGS6 exists in multiple splice isoforms with identical RGS domains, but possess complete or incomplete GGL domains and distinct N- and C-terminal domains. RGS6 interacts with SCG10, a neuronal growth-associated protein and therefore regulates neuronal differentiation. Another RGS6-binding protein is DMAP1, a component of the Dnmt1 complex involved in repression of newly replicated genes. Mutations of a critical residue required for interaction of RGS6 protein with G proteins did not affect the ability of RGS6 to interact with both SCG10 and DMAP1. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis.

Pssm-ID: 188691 Cd Length: 125 Bit Score: 106.25 E-value: 3.12e-29

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120077  98 VLSWSQNFDKMMKTPAGRNLFREFLRTEYSEENLLFWLACEDLKKeQNKKAVEEKARMIYEDYISILSPKEVSLDSRVRE 177
Cdd:cd08737    3 VKRWGFSLDEVLKDPVGRDQFLRFLESEFSSENLRFWLAVQDLKK-QPLQDVAKRVEEIWQEFLAPGAPSAINLDSHSYE 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 240120077 178 VINRSLLDPSPHMYEDAQLQIYTLMHRDSFPRFLNSQIYK 217
Cdd:cd08737   82 KTSQNVKDPGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQ 121

RGS_RGS10

cd08741

Regulator of G protein signaling (RGS) domain found in the RGS10 protein; RGS (Regulator of ...

105-216

3.89e-29

Regulator of G protein signaling (RGS) domain found in the RGS10 protein; RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS10 protein. RGS10 is a member of the RA/RGS subfamily of RGS proteins family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS10 belong to the R12 RGS subfamily, which includes RGS12 and RGS14, all of which are highly selective for G-alpha-i1 over G-alpha-q. RGS10 exists in 2 splice isoforms. RGS10A is specifically expressed in osteoclasts and is a key component in the RANKL signaling mechanism for osteoclast differentiation, whereas RGS10B expressed in brain and in immune tissues and has been implicated in diverse processes including: promoting of dopaminergic neuron survival via regulation of the microglial inflammatory response, modulation of presynaptic and postsynaptic G-protein signalling, as well as a possible role in regulation of gene expression.

Pssm-ID: 188695 Cd Length: 113 Bit Score: 105.51 E-value: 3.89e-29

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120077 105 FDKMMKTPAGRNLFREFLRTEYSEENLLFWLACEDLKKEQNKKAVEEKARMIYEDYISILSPKEVSLD--SRVREVInrs 182
Cdd:cd08741    1 LENLLEDPEGVKRFREFLKKEFSEENVLFWLACEDFKKMQDKTQMQEKAKEIYMTFLSSKASSQVNVEgqSRLNEKI--- 77

                         90       100       110
                 ....*....|....*....|....*....|....
gi 240120077 183 LLDPSPHMYEDAQLQIYTLMHRDSFPRFLNSQIY 216
Cdd:cd08741   78 LEEPHPLMFQKLQDQIFNLMKYDSYSRFLKSDLF 111

RGS_RGS9

cd08739

Regulator of G protein signaling (RGS) domain found in the RGS9 protein; The RGS (Regulator of ...

98-217

4.73e-29

Regulator of G protein signaling (RGS) domain found in the RGS9 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS9 protein, a member of R7 subfamily of the RGS protein family. RGS is a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. Other members of the R7 subfamily (Neuronal RGS) include: RGS6, RGS7, and RGS11, all of which are expressed predominantly in the nervous system, form an obligatory complex with G-beta-5, and play important roles in the regulation of crucial neuronal processes such as vision and motor control. Additionally they have been implicated in many neurological conditions such as anxiety, schizophrenia, and drug dependence. RGS9 forms constitutive complexes with G-beta-5 subunit and controls such fundamental functions as vision and behavior. RGS9 exists in two splice isoforms: RGS9-1 which regulates phototransduction in rods and cones and RGS9-2 which regulates dopamine and opioid signaling in the basal ganglia. In addition, RGS9 was found to bind many other proteins outside of G protein signaling pathways including: mu-opioid receptor, beta-arrestin, alpha-actinin-2, NMDAR, polycystin, spinophilin, and guanylyl cyclase, among others.

Pssm-ID: 188693 Cd Length: 121 Bit Score: 105.49 E-value: 4.73e-29

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120077  98 VLSWSQNFDKMMKTPAGRNLFREFLRTEYSEENLLFWLACEDLKKEQNKKaVEEKARMIYEDYISILSPKEVSLDSRVRE 177
Cdd:cd08739    2 VERWAFNFSELIRDPKGRQSFQLFLKKEFSGENLGFWEACEDLKYGDQSK-VKEKAEEIYKLFLAPGARRWINIDGKTMD 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 240120077 178 VINRSLLDPSPHMYEDAQLQIYTLMHRDSFPRFLNSQIYK 217
Cdd:cd08739   81 ITVKGLKHPHRYVLDAAQTHIYMLMKKDSYARYLKSPIYK 120

RGS_RGS11

cd08740

Regulator of G protein signaling (RGS) domain found in the RGS11 protein; The RGS (Regulator ...

98-220

3.10e-26

Regulator of G protein signaling (RGS) domain found in the RGS11 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS11 protein, a member of R7 subfamily of the RGS protein family. RGS is a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. Other members of the R7 subfamily (Neuronal RGS) include: RGS6, RGS7, and RGS9, all of which are expressed predominantly in the nervous system, form an obligatory complex with G-beta-5, and play important roles in the regulation of crucial neuronal processes such as vision and motor control. Additionally they have been implicated in many neurological conditions such as anxiety, schizophrenia, and drug dependence. RGS11 is expressed exclusively in retinal ON-bipolar neurons in which it forms complexes with G-beta-5 and R7AP (RGS7 anchor protein ) and plays crucial roles in processing the light responses of retinal neurons.

Pssm-ID: 188694 Cd Length: 126 Bit Score: 98.45 E-value: 3.10e-26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120077  98 VLSWSQNFDKMMKTPAGRNLFREFLRTEYSEENLLFWLACEDLKKEQNKKaVEEKARMIYEDYISILSPKEVSLDSRVRE 177
Cdd:cd08740    3 VERWGFSFRELLNDPVGRKEFLDFLEKEFSAENLSFWEACEELRYGEQSK-IPELVDSVYQQFLAPGATRWVNIDSKTME 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 240120077 178 VINRSLLDPSPHMYEDAQLQIYTLMHRDSFPRFLNSQIYKAFV 220
Cdd:cd08740   82 RTLEGLKQPHRYVLDDAQMHIYMLMKKDSYPRFLKSDLYKNLL 124

RGS_RGS7

cd08738

Regulator of G protein signaling (RGS) domain found in the RGS7 protein; The RGS (Regulator of ...

98-217

1.68e-25

Regulator of G protein signaling (RGS) domain found in the RGS7 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS7 protein, a member of R7 subfamily of the RGS protein family. RGS is a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. Other members of the R7 subfamily (Neuronal RGS) include: RGS6, RGS9, and RGS11, all of which are expressed predominantly in the nervous system, form an obligatory complex with G-beta-5, and play important roles in the regulation of crucial neuronal processes such as vision and motor control. Additionally they have been implicated in many neurological conditions such as anxiety, schizophrenia, and drug dependence. R7 RGS proteins are key modulators of the pharmacological effects of drugs involved in the development of tolerance and addiction. In addition, RGS7 was found to bind a component of the synaptic fusion complex, snapin, and some other proteins outside of G protein signaling pathways.

Pssm-ID: 188692 Cd Length: 121 Bit Score: 96.32 E-value: 1.68e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120077  98 VLSWSQNFDKMMKTPAGRNLFREFLRTEYSEENLLFWLACEDLKKEQNKKaVEEKARMIYEDYISILSPKEVSLDSRVRE 177
Cdd:cd08738    2 VKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIRE-VPSRVQEIWQEFLAPGAPSAINLDSKSYD 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 240120077 178 VINRSLLDPSPHMYEDAQLQIYTLMHRDSFPRFLNSQIYK 217
Cdd:cd08738   81 KTTQNVKDPGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQ 120

RGS_RGS14

cd08743

Regulator of G protein signaling (RGS) domain found in the RGS14 protein; RGS (Regulator of ...

98-218

6.49e-24

Regulator of G protein signaling (RGS) domain found in the RGS14 protein; RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS14 protein. RGS14 is a member of the RA/RGS subfamily of RGS proteins family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS14 belong to the R12 RGS subfamily, which includes RGS10 and RGS12, all of which are highly selective for G-alpha-i1 over G-alpha-q. RGS14 binds and regulates the subcellular localization and activities of H-Ras and Raf kinases in cells and thereby integrates G protein and Ras/Raf signaling pathways.

Pssm-ID: 188697 Cd Length: 129 Bit Score: 92.40 E-value: 6.49e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120077  98 VLSWSQNFDKMMKTPAGRNLFREFLRTEYSEENLLFWLACEDLKKEQNKKAVE--EKARMIYEDYISILSPKEVSLDSRV 175
Cdd:cd08743    4 VASWAVSFERLLQDPLGVEYFTEFLKKEFSAENVNFWKACERFQQIPASDTQQlaQEARKIYNEFLSSSSQSPVNIDQQA 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 240120077 176 ReVINRSLLDPSPHMYEDAQLQIYTLMHRDSFPRFLNSQIYKA 218
Cdd:cd08743   84 W-IGEDMLATPSPDMFRAQQLQIFNLMKFDSYARFVKSPLYQD 125

RGS_RGS12

cd08742

Regulator of G protein signaling (RGS) domain found in the RGS12 protein; RGS (Regulator of ...

105-217

1.35e-22

Regulator of G protein signaling (RGS) domain found in the RGS12 protein; RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS12 protein. RGS12 is a member of the RA/RGS subfamily of RGS proteins family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS12 belong to the R12 RGS subfamily, which includes RGS10 and RGS14, all of which are highly selective for G-alpha-i1 over G-alpha-q. RGS12 exist in multiple splice variants: RGS12s (short) contains the core RGS/RBD/GoLoco domains, while RGS12L (long) has additional N-terminal PDZ and PTB domains. RGS12 splice variants show distinct expression patterns, suggesting that they have discrete functions during mouse embryogenesis. RGS12 also may play a critical role in coordinating Ras-dependent signals that are required for promoting and maintaining neuronal differentiation.

Pssm-ID: 188696 Cd Length: 115 Bit Score: 88.58 E-value: 1.35e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120077 105 FDKMMKTPAGRNLFREFLRTEYSEENLLFWLACEDLKK--EQNKKAVEEKARMIYEDYISILSPKEVSLDSRVrEVINRS 182
Cdd:cd08742    1 FERLLQDPVGVRYFSEFLRKEFSEENILFWQACEYFNHvpAHDKKELSYRAREIFSKFLCSKATTPVNIDSQA-QLADDI 79

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 240120077 183 LLDPSPHMYEDAQLQIYTLMHRDSFPRFLNSQIYK 217
Cdd:cd08742   80 LNAPHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQ 114

RGS_Axin

cd08707

Regulator of G protein signaling (RGS) domain found in the Axin protein; The RGS (Regulator of ...

114-217

3.26e-15

Regulator of G protein signaling (RGS) domain found in the Axin protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the Axin protein. Axin is a member of the RA/RGS subfamily of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, and skeletal and muscle development. The RGS domain of Axin is specifically interacts with the heterotrimeric G-alpha12 protein, but not with closely related G-alpha13, and provides a unique tool to regulate G-alpha12-mediated signaling processes. The RGS domain of Axin also interacts with the tumor suppressor protein APC (Adenomatous Polyposis Coli) in order to control the cytoplasmic level of the proto-oncogene, beta-catenin.

Pssm-ID: 188662 Cd Length: 117 Bit Score: 69.41 E-value: 3.26e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120077 114 GRNLFREFLRTEYSEENLLFWLACEDLKKEQNKKAVEEK-ARMIYEDYI----SILSPKEVSLDSRVREVINRSLLDPsp 188
Cdd:cd08707   10 GIELFRTYLEQEGCADLLDFWFACNGFRKMSDSEEKRSKlAKAIYRRYIkdngIVSRQLKPATKSFIKECIKKQQLDP-- 87

                         90       100
                 ....*....|....*....|....*....
gi 240120077 189 HMYEDAQLQIYTLMHRDSFPRFLNSQIYK 217
Cdd:cd08707   88 AMFDQAQTEIQTTMEENTYPSFLKSDIYL 116

RGS_AKAP2_2

cd08721

Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, ...

118-216

2.46e-10

Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, D-AKAP2; The RGS (Regulator of G-protein Signaling) domain is an essential part of the D-AKAP2 (A-kinase anchoring protein), a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. D-AKAP2 contains two RGS domains which play an important role in spatiotemporal localization of cAMP-dependent PKA (cyclic AMP-dependent protein kinase) that regulates many different signaling pathways by phosphorylation of target proteins. This cd contains the second RGS domain.

Pssm-ID: 188676 Cd Length: 121 Bit Score: 56.20 E-value: 2.46e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120077 118 FREFLRTEYSEENLLFWLACEDLKK-------EQNKKAVEEKARMIYEDYISILSPKEVSLDSRVREVINRSLL---DPS 187
Cdd:cd08721   11 FMEYMEQEGARNLLQFWLAADNFQSqlaakegQYDGQQAQNDAMIIYDKYFSLQATEPLGFDDKTRLEVESNICregGPL 90

                         90       100
                 ....*....|....*....|....*....
gi 240120077 188 PHMYEDAQLQIYTLMHRDSFPRFLNSQIY 216
Cdd:cd08721   91 PSCFEAPLLQALTTLEQHYLPGFLSSQLY 119

RGS_FLBA

cd08708

Regulator of G protein signaling (RGS) domain found in the FLBA (Fluffy Low BrlA) protein; The ...

104-218

9.33e-10

Regulator of G protein signaling (RGS) domain found in the FLBA (Fluffy Low BrlA) protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the FLBA (Fluffy Low BrlA) protein. FLBA is a member of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins play a critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of the G-protein signaling controlled by the RGS domain accelerates the GTPase activity of the alpha subunit by hydrolysis of GTP to GDP which results in reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes. The RGS domain of the FLBA protein antagonizes G protein signaling to block proliferation and allow development. It is required for control of mycelial proliferation and activation of asexual sporulation in yeast.

Pssm-ID: 188663 Cd Length: 148 Bit Score: 55.46 E-value: 9.33e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120077 104 NFDKMMKTPAGRNLFREFLRTEYSEENLLFWL-------ACEDLKKEQNKKAVEEK-----------ARMIYEDYISILS 165
Cdd:cd08708    1 RLDKILKDPGLRYLFREHLEKEFCEENLSFYLevkeflkKMTILSKLLDFKSSQAAdedldreslaqAYHIYNTYLAPGS 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 240120077 166 PKEVSLDSRVREVINRSLLDPSPHM--------------YEDAQLQIY-TLMHRDSFPRFLNSQIYKA 218
Cdd:cd08708   81 PCELNIDHNLRNRITTIMTEKIVGEddsmaeslqgvealFEEAQNAVFkPLMAGDSVPKFLKQPEYLG 148

RGS_SNX25

cd08720

Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 25 (SNX25) protein; ...

108-217

1.81e-08

Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 25 (SNX25) protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the SNX25 (Sorting Nexin 25) protein, a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. SNX25 is a member of the Dopamine receptors (DAR) signalplex and regulates the trafficking of D1 and D2 DARs.

Pssm-ID: 188675 Cd Length: 110 Bit Score: 50.88 E-value: 1.81e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120077 108 MMKTPAGRNLFREFLRTEYSEENLLFWLACEDLkKEQNKKAVEEKARMIYEDYISIlSPKEVSLDSRVREVINRSLL-DP 186
Cdd:cd08720    1 ILANVFGRKYLSQFLERMDSQALIGFWEAVEEL-RSANKSEWHQLGAEIFYTFIVE-PTAEIKVDKSLRKRIEQFLLgDK 78

                         90       100       110
                 ....*....|....*....|....*....|.
gi 240120077 187 SPHMYEDAQLQIYTLMHRDSFPRFLNSQIYK 217
Cdd:cd08720   79 GPEVFYEVQENVVETLEEKYYPSFVVSDQYK 109

RGS_SNX13

cd08719

Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein; ...

118-216

1.55e-06

Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the SNX13 (Sorting Nexin 13) protein, a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. The RGS-domain of SNX13 plays a major role through attenuation of Galphas-mediated signaling and regulates endocytic trafficking and degradation of the epidermal growth factor receptor. Snx13-null mice were embryonic lethal around midgestation which supports an essential role for SNX13 in mouse development and regulation of endocytosis dynamics.

Pssm-ID: 188674 Cd Length: 135 Bit Score: 46.25 E-value: 1.55e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120077 118 FREFLRTEYSEENLLFWLACE-----------DLKKEQ---------NKKAVEEKARMIYEDYISILSPKEVSLDS---- 173
Cdd:cd08719   11 FIDFMQSVGGQAYLFFWLTVEgyrvsaeqqlsELHLRQrggehqrsdVYEMLRAAALNIYDQYLSEKASPRVPLDDslvk 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 240120077 174 RVREVINRSllDPSPHMYEDAQLQIYTLMHRDS--FPRFLNSQIY 216
Cdd:cd08719   91 KLLNRLRND--TPSDLWFDDIQQKVFDIMQEDErfYPAFKKSPAY 133

RGS-like_2

cd08728

Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 2; These ...

116-171

7.74e-06

Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 2; These uncharacterized RGS-like domains consists largely of hypothetical proteins. The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play an important role in neuronal signal modulation. Some RGS proteins are the principal elements needed for proper vision.

Pssm-ID: 188683 Cd Length: 179 Bit Score: 44.83 E-value: 7.74e-06

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 240120077 116 NLFREFLRTEYSEENLLFWLACEDLKKEQNKKAVEEKARMIYEDYISILSPKEVSL 171
Cdd:cd08728    8 EYFKRFLKSRGSDGPLLFWIAVEKMRVEENEKEQKAKIELIVKRYFHGQDPPGVLL 63

RGS_GRK-like

cd08724

Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase (GRK); ...

110-213

4.75e-04

Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase (GRK); The RGS domain is found in G protein-coupled receptor kinases (GRKs). These proteins play a key role in phosphorylation-dependent desensitization/resensitization of GPCRs (G protein-coupled receptors), intracellular trafficking, endocytosis, as well as in the modulation of important intracellular signaling cascades by GPCR. GRKs also modulate cellular response in phosphorylation-independent manner using their ability to interact with multiple signaling proteins involved in many essential cellular pathways. The RGS domain of the GRKs has very little sequence similarity with the canonical RGS domain of the RGS proteins and therefore is often refered to as the RH (RGS Homology) domain. Based on sequence homology the GRK family consists of three major subfamilies: the GRK4 subfamily (GRK4, GRK5 and GRK6), the rhodopsin kinase or visual GRK subfamily (GRK1 and GRK7), and the beta-adrenergic receptor kinases subfamily (GRK2/GRK3). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development.

Pssm-ID: 188679 Cd Length: 114 Bit Score: 38.71 E-value: 4.75e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120077 110 KTPAGRNLFREFLRTeySEEN---LLFWLACEDLKK-EQNKKAveEKARMIYEDYISILSPKEVS--LDSRVREVINRSL 183
Cdd:cd08724    4 QQPIGRLLFRQFCET--RPELvpqIEFLDEIKEYEVaEDEERA--KKAREIYDKYIMKESLAHSHefSKDAVEHVQENLE 79

                         90       100       110
                 ....*....|....*....|....*....|
gi 240120077 184 LDPSPHMYEDAQLQIYTLMHRDSFPRFLNS 213
Cdd:cd08724   80 KEVPKDLFQPYIEEIHDYLRGAPFQKFLES 109

RGS_RGS22_1

cd08731

Regulator of G protein signaling domain RGS_RGS22_1; The RGS (Regulator of G-protein Signaling) ...

114-224

8.98e-04

Regulator of G protein signaling domain RGS_RGS22_1; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family, which is a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.

Pssm-ID: 188686 Cd Length: 125 Bit Score: 38.09 E-value: 8.98e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120077 114 GRNLFREFLRTEYSEENLLFWLACEDLKKEQNKKAVEEKARMIYEDYIS----ILSPKEVSLDSRVREVINRSLLDPSPH 189
Cdd:cd08731    7 GLEVFKAFLLNTRGEKLFVFWLDVEPYKAKDKVEAYLQSKRIFAKYQVAstkrELLPPSAEPLRTRVLNAAAKKLEPKIN 86

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 240120077 190 -MYEDAQLQIYTLMH---RDSFPRFLNSQIYKAFVESTT 224
Cdd:cd08731   87 kNFARIQLDIFRGLEslvLDHMTRTAFPQFLSSYPDYLA 125

RGS_PX

cd08729

Regulator of G protein signaling domain; These uncharacterized RGS-like domains are found in ...

109-216

2.53e-03

Regulator of G protein signaling domain; These uncharacterized RGS-like domains are found in proteins that also contain one or more PX domains. The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. As a major G-protein regulator, the RGS domain containing proteins that are involves in many crucial cellular processes. RGS proteins regulate intracellular trafficking and provide vital support for signal transduction. RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. Several RGS proteins can fine-tune immune responses, others RGS proteins play important role in neuronal signals modulation. Some RGS proteins are the principal elements needed for proper vision.

Pssm-ID: 188684 Cd Length: 136 Bit Score: 37.06 E-value: 2.53e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120077 109 MKTPAGRNLFREFLRTEYSEENLLFWLACEDLKKEQNK----------------KAVEEKARMIYEDYISILSPKE-VSL 171
Cdd:cd08729    1 LRDPSSLSYFMEFMDRRNRSQLVQFWLVVEGFKNPLEDtendysldssqsrswiDSDKEDIAMIYETYFSDPSPSLnVPK 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 240120077 172 DSR--VREVINRSL-LDPSPHMYED------AQLQIYTLMHRDSFPRFLNSQIY 216
Cdd:cd08729   81 ASRdpIRLFLNAGVnASPNEQYRKArravlmAQRAVYEEMEEEDFPEFKKSELF 134

RGS-like_1

cd08734

Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 1; These ...

117-176

4.34e-03

Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 1; These uncharacterized RGS-like domains consists largely of hypothetical proteins. The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. As a major G-protein regulator, the RGS domain containing proteins that are involved in many crucial cellular processes. RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play an important role in neuronal signal modulation. Some RGS proteins are the principal elements needed for proper vision.

Pssm-ID: 188688 Cd Length: 109 Bit Score: 35.90 E-value: 4.34e-03

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120077 117 LFREFLRTEYSEENLLFWLACEDLKKEQNKKAVEEKARMIYEDYISILSPKEVSLDSRVR 176
Cdd:cd08734    7 LFGFSAESDFSGENLSFLTLVKEYKRLSNPAEKFTLASKIYKEFISSESPFQINISSAML 66

RGS_AKAP2_1

cd08735

Regulator of G protein signaling (RGS) domain 1 found in the A-kinase anchoring protein, ...

138-216

5.28e-03

Regulator of G protein signaling (RGS) domain 1 found in the A-kinase anchoring protein, D-AKAP2; The RGS (Regulator of G-protein Signaling) domain is an essential part of the D-AKAP2 (A-kinase anchoring protein), a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. D-AKAP2 contains two RGS domains which play an important role in spatiotemporal localization of cAMP-dependent PKA (cyclic AMP-dependent protein kinase) that regulates many different signaling pathways by phosphorylation of target proteins. This cd contains the first RGS domain.

Pssm-ID: 188689 [Multi-domain] Cd Length: 171 Bit Score: 36.66 E-value: 5.28e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120077 138 EDLKKEQNKKAVEEKARMIYEDYISILSPKEVSLDSRVREVINRSLLDP----SPHMYEDAQLQIYTLMHRDSFPRFLNS 213
Cdd:cd08735   87 TDDDDEKSMKSIERDAVSIYTKYISPDAAKPIPITEEIRNDIVAKICGEdgqvDPNCFVEAQSFVFSAMEQDHFTEFLRS 166


                 ...
gi 240120077 214 QIY 216
Cdd:cd08735  167 HFF 169

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01