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Conserved domains on  [gi|354542551|ref|NP_001238913|]
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calcipressin-3 isoform 5 [Homo sapiens]

Protein Classification

RNA-binding protein( domain architecture ID 106745)

RNA-binding protein containing an RNA recognition motif (RRM)

CATH:  3.30.70.330
Gene Ontology:  GO:0003723
PubMed:  15853797
SCOP:  3000110

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RRM_SF super family cl17169
RNA recognition motif (RRM) superfamily; RRM, also known as RBD (RNA binding domain) or RNP ...
 2-99 1.01e-36

RNA recognition motif (RRM) superfamily; RRM, also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA processing, RNA export, and RNA stability. This domain is 90 amino acids in length and consists of a four-stranded beta-sheet packed against two alpha-helices. RRM usually interacts with ssRNA, but is also known to interact with ssDNA as well as proteins. RRM binds a variable number of nucleotides, ranging from two to eight. The active site includes three aromatic side-chains located within the conserved RNP1 and RNP2 motifs of the domain. The RRM domain is found in a variety heterogeneous nuclear ribonucleoproteins (hnRNPs), proteins implicated in regulation of alternative splicing, and protein components of small nuclear ribonucleoproteins (snRNPs).


The actual alignment was detected with superfamily member pfam04847:

Pssm-ID: 473069  Cd Length: 183  Bit Score: 123.07  E-value: 1.01e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354542551    2 SGEVRDKSYLLPPQPVKQFLISPPASPPVGWKQSEDAMP---VINYDLLCAVSKLGPGEKYELHAGTESTPSVVV----- 73
Cdd:pfam04847  72 IQRDLAKSHLAPPQPEKQFLISPPASPPVGWEQKEEDAPnrhVLNEDLQYALAKLGPGEKYQLHAGTDTTPSVVVtllks 151

                          90       100       110
                  ....*....|....*....|....*....|.
gi 354542551   74 HVCES-----ETEEEEETKNPKQKIAQTRRP 99
Cdd:pfam04847 152 HVGESeideeETNGDGDTPRPKPKIIQTARP 182
 
Name Accession Description Interval E-value
Calcipressin pfam04847
Calcipressin; Calcipressin is also known as calcineurin-binding protein, since it inhibits ...
 2-99 1.01e-36

Calcipressin; Calcipressin is also known as calcineurin-binding protein, since it inhibits calcineurin-mediated transcriptional modulation by binding to calcineurin's catalytic domain.


Pssm-ID: 282674  Cd Length: 183  Bit Score: 123.07  E-value: 1.01e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354542551    2 SGEVRDKSYLLPPQPVKQFLISPPASPPVGWKQSEDAMP---VINYDLLCAVSKLGPGEKYELHAGTESTPSVVV----- 73
Cdd:pfam04847  72 IQRDLAKSHLAPPQPEKQFLISPPASPPVGWEQKEEDAPnrhVLNEDLQYALAKLGPGEKYQLHAGTDTTPSVVVtllks 151

                          90       100       110
                  ....*....|....*....|....*....|.
gi 354542551   74 HVCES-----ETEEEEETKNPKQKIAQTRRP 99
Cdd:pfam04847 152 HVGESeideeETNGDGDTPRPKPKIIQTARP 182
 
Name Accession Description Interval E-value
Calcipressin pfam04847
Calcipressin; Calcipressin is also known as calcineurin-binding protein, since it inhibits ...
 2-99 1.01e-36

Calcipressin; Calcipressin is also known as calcineurin-binding protein, since it inhibits calcineurin-mediated transcriptional modulation by binding to calcineurin's catalytic domain.


Pssm-ID: 282674  Cd Length: 183  Bit Score: 123.07  E-value: 1.01e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354542551    2 SGEVRDKSYLLPPQPVKQFLISPPASPPVGWKQSEDAMP---VINYDLLCAVSKLGPGEKYELHAGTESTPSVVV----- 73
Cdd:pfam04847  72 IQRDLAKSHLAPPQPEKQFLISPPASPPVGWEQKEEDAPnrhVLNEDLQYALAKLGPGEKYQLHAGTDTTPSVVVtllks 151

                          90       100       110
                  ....*....|....*....|....*....|.
gi 354542551   74 HVCES-----ETEEEEETKNPKQKIAQTRRP 99
Cdd:pfam04847 152 HVGESeideeETNGDGDTPRPKPKIIQTARP 182
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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