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Conserved domains on  [gi|409168306|ref|NP_001258494|]
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armadillo repeat-containing protein 3 isoform 4 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HEAT COG1413
HEAT repeat [General function prediction only];
62-216 3.85e-07

HEAT repeat [General function prediction only];


:

Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 50.01  E-value: 3.85e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409168306  62 TLLELG---AVEPLTKLLTHEDKTVRRNAMMIFGILASNSDVKKLLRELEvmnsviaqlSPEEEVVIHefASLCLANMSV 138
Cdd:COG1413    8 ALGRLGdpaAVPALIAALADEDPDVRAAAARALGRLGDPRAVPALLEALK---------DPDPEVRAA--AAEALGRIGD 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 409168306 139 EytgkvqifehGGLEPLIRLLSSSDPDVKKNSIECIYNlvqdfqcrttLQELNAIPPILELLRSEYPIIQLLALKTLG 216
Cdd:COG1413   77 P----------EAVPALIAALKDEDPEVRRAAAEALGR----------LGDPAAVPALLEALKDPDWEVRRAAARALG 134
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 469-504 9.11e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 37.41  E-value: 9.11e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 409168306   469 DVEARTQLRNCGGLVPLVGLLHSKNDEVRRHASWAV 504
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWAL 36
SRP1 super family cl34886
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
358-504 2.40e-03

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5064:

Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 41.03  E-value: 2.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409168306 358 IPQIVQLLRSDNEEVREAAALALANLTTSSPANANAAAEADAIDPLINIL-SSKRDGAIANAAT-VLTNM---------- 425
Cdd:COG5064  159 VPLFIQLLSSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLLlSSAIHISMLRNATwTLSNLcrgknpppdw 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409168306 426 ----------------------------------ATQEPLRAIIqNHEIMHALLGPLHSTNTLVQSTAALTVAATACDVE 471
Cdd:COG5064  239 snisqalpilakliysrdpevlvdacwaisylsdGPNEKIQAVL-DVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSD 317

                        170       180       190
                 ....*....|....*....|....*....|....
gi 409168306 472 ARTQ-LRNCGGLVPLVGLLHSKNDEVRRHASWAV 504
Cdd:COG5064  318 DQTQvIINCGALKAFRSLLSSPKENIRKEACWTI 351
 
Name Accession Description Interval E-value
HEAT COG1413
HEAT repeat [General function prediction only];
62-216 3.85e-07

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 50.01  E-value: 3.85e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409168306  62 TLLELG---AVEPLTKLLTHEDKTVRRNAMMIFGILASNSDVKKLLRELEvmnsviaqlSPEEEVVIHefASLCLANMSV 138
Cdd:COG1413    8 ALGRLGdpaAVPALIAALADEDPDVRAAAARALGRLGDPRAVPALLEALK---------DPDPEVRAA--AAEALGRIGD 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 409168306 139 EytgkvqifehGGLEPLIRLLSSSDPDVKKNSIECIYNlvqdfqcrttLQELNAIPPILELLRSEYPIIQLLALKTLG 216
Cdd:COG1413   77 P----------EAVPALIAALKDEDPEVRRAAAEALGR----------LGDPAAVPALLEALKDPDWEVRRAAARALG 134
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 143-178 6.67e-05

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 40.52  E-value: 6.67e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 409168306  143 KVQIFEHGGLEPLIRLLSSSDPDVKKNSIECIYNLV 178
Cdd:pfam00514   5 KQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 32-182 3.20e-04

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 44.32  E-value: 3.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409168306   32 LMLKSPEEDILAKACEAiykfalkgeeNKAtllelgaVEPLTKLLTH-EDKTVRRNAMMIFGILASNSDVKKLLRELEVM 110
Cdd:PLN03200  591 VLSVASLEDLVREGSAA----------NDA-------LRTLIQLLSSsKEETQEKAASVLADIFSSRQDLCESLATDEII 653

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 409168306  111 NSVIAQLSPEEEVVIHEfASLCLANM--SVEYTGKVQIFEHGGLEPLIRLLSSSDPDVKKNSIECIYNLVQDFQ 182
Cdd:PLN03200  654 NPCIKLLTNNTEAVATQ-SARALAALsrSIKENRKVSYAAEDAIKPLIKLAKSSSIEVAEQAVCALANLLSDPE 726
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 469-504 9.11e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 37.41  E-value: 9.11e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 409168306   469 DVEARTQLRNCGGLVPLVGLLHSKNDEVRRHASWAV 504
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWAL 36
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 145-179 1.18e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 37.02  E-value: 1.18e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 409168306   145 QIFEHGGLEPLIRLLSSSDPDVKKNSIECIYNLVQ 179
Cdd:smart00185   7 AVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
358-504 2.40e-03

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 41.03  E-value: 2.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409168306 358 IPQIVQLLRSDNEEVREAAALALANLTTSSPANANAAAEADAIDPLINIL-SSKRDGAIANAAT-VLTNM---------- 425
Cdd:COG5064  159 VPLFIQLLSSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLLlSSAIHISMLRNATwTLSNLcrgknpppdw 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409168306 426 ----------------------------------ATQEPLRAIIqNHEIMHALLGPLHSTNTLVQSTAALTVAATACDVE 471
Cdd:COG5064  239 snisqalpilakliysrdpevlvdacwaisylsdGPNEKIQAVL-DVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSD 317

                        170       180       190
                 ....*....|....*....|....*....|....
gi 409168306 472 ARTQ-LRNCGGLVPLVGLLHSKNDEVRRHASWAV 504
Cdd:COG5064  318 DQTQvIINCGALKAFRSLLSSPKENIRKEACWTI 351
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 469-504 2.57e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 36.28  E-value: 2.57e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 409168306  469 DVEARTQLRNCGGLVPLVGLLHSKNDEVRRHASWAV 504
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWAL 36
 
Name Accession Description Interval E-value
HEAT COG1413
HEAT repeat [General function prediction only];
62-216 3.85e-07

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 50.01  E-value: 3.85e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409168306  62 TLLELG---AVEPLTKLLTHEDKTVRRNAMMIFGILASNSDVKKLLRELEvmnsviaqlSPEEEVVIHefASLCLANMSV 138
Cdd:COG1413    8 ALGRLGdpaAVPALIAALADEDPDVRAAAARALGRLGDPRAVPALLEALK---------DPDPEVRAA--AAEALGRIGD 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 409168306 139 EytgkvqifehGGLEPLIRLLSSSDPDVKKNSIECIYNlvqdfqcrttLQELNAIPPILELLRSEYPIIQLLALKTLG 216
Cdd:COG1413   77 P----------EAVPALIAALKDEDPEVRRAAAEALGR----------LGDPAAVPALLEALKDPDWEVRRAAARALG 134
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 143-178 6.67e-05

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 40.52  E-value: 6.67e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 409168306  143 KVQIFEHGGLEPLIRLLSSSDPDVKKNSIECIYNLV 178
Cdd:pfam00514   5 KQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
HEAT COG1413
HEAT repeat [General function prediction only];
83-230 6.85e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 43.46  E-value: 6.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409168306  83 VRRNAMMIFGILASNSDVKKLLRELEvmnsviaqlspEEEVVIHEFASLCLAnmsveytgkvQIFEHGGLEPLIRLLSSS 162
Cdd:COG1413    1 VRRAAARALGRLGDPAAVPALIAALA-----------DEDPDVRAAAARALG----------RLGDPRAVPALLEALKDP 59

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 409168306 163 DPDVKKNSIECIYNlvqdfqcrttLQELNAIPPILELLRSEYPIIQLLALKTLGVITcDKEARTMLKE 230
Cdd:COG1413   60 DPEVRAAAAEALGR----------IGDPEAVPALIAALKDEDPEVRRAAAEALGRLG-DPAAVPALLE 116
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 32-182 3.20e-04

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 44.32  E-value: 3.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409168306   32 LMLKSPEEDILAKACEAiykfalkgeeNKAtllelgaVEPLTKLLTH-EDKTVRRNAMMIFGILASNSDVKKLLRELEVM 110
Cdd:PLN03200  591 VLSVASLEDLVREGSAA----------NDA-------LRTLIQLLSSsKEETQEKAASVLADIFSSRQDLCESLATDEII 653

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 409168306  111 NSVIAQLSPEEEVVIHEfASLCLANM--SVEYTGKVQIFEHGGLEPLIRLLSSSDPDVKKNSIECIYNLVQDFQ 182
Cdd:PLN03200  654 NPCIKLLTNNTEAVATQ-SARALAALsrSIKENRKVSYAAEDAIKPLIKLAKSSSIEVAEQAVCALANLLSDPE 726
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 469-504 9.11e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 37.41  E-value: 9.11e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 409168306   469 DVEARTQLRNCGGLVPLVGLLHSKNDEVRRHASWAV 504
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWAL 36
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 145-179 1.18e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 37.02  E-value: 1.18e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 409168306   145 QIFEHGGLEPLIRLLSSSDPDVKKNSIECIYNLVQ 179
Cdd:smart00185   7 AVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
11-177 1.29e-03

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 42.18  E-value: 1.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409168306  11 PPPkdvfDPITIeSKKAATVVLMLKSPEEDILAKACEAIYKFALKGEENKATLLELGAVEPLTKLLTHEDKTVRRNAMMI 90
Cdd:COG5064  234 PPP----DWSNI-SQALPILAKLIYSRDPEVLVDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRS 308

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409168306  91 FGILASNSDVK-KLLRELEVMNSVIAQLSPEEEVVIHEfASLCLANMSVEYTGKVQ-IFEHGGLEPLIRLLSSSDPDVKK 168
Cdd:COG5064  309 VGNIVTGSDDQtQVIINCGALKAFRSLLSSPKENIRKE-ACWTISNITAGNTEQIQaVIDANLIPPLIHLLSSAEYKIKK 387


                 ....*....
gi 409168306 169 NSIECIYNL 177
Cdd:COG5064  388 EACWAISNA 396
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 57-87 2.09e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 36.28  E-value: 2.09e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 409168306   57 EENKATLLELGAVEPLTKLLTHEDKTVRRNA 87
Cdd:pfam00514   2 PENKQAVIEAGAVPPLVRLLSSPDEEVQEEA 32
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
358-504 2.40e-03

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 41.03  E-value: 2.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409168306 358 IPQIVQLLRSDNEEVREAAALALANLTTSSPANANAAAEADAIDPLINIL-SSKRDGAIANAAT-VLTNM---------- 425
Cdd:COG5064  159 VPLFIQLLSSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLLlSSAIHISMLRNATwTLSNLcrgknpppdw 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 409168306 426 ----------------------------------ATQEPLRAIIqNHEIMHALLGPLHSTNTLVQSTAALTVAATACDVE 471
Cdd:COG5064  239 snisqalpilakliysrdpevlvdacwaisylsdGPNEKIQAVL-DVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSD 317

                        170       180       190
                 ....*....|....*....|....*....|....
gi 409168306 472 ARTQ-LRNCGGLVPLVGLLHSKNDEVRRHASWAV 504
Cdd:COG5064  318 DQTQvIINCGALKAFRSLLSSPKENIRKEACWTI 351
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 469-504 2.57e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 36.28  E-value: 2.57e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 409168306  469 DVEARTQLRNCGGLVPLVGLLHSKNDEVRRHASWAV 504
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWAL 36
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 57-96 5.11e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 35.48  E-value: 5.11e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 409168306    57 EENKATLLELGAVEPLTKLLTHEDKTVRRNAMMIFGILAS 96
Cdd:smart00185   2 DENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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