NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|595763372|ref|NP_001277724|]
View 

WD repeat domain phosphoinositide-interacting protein 4 isoform b [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl43672
WD40 repeat [General function prediction only];
167-239 3.37e-04

WD40 repeat [General function prediction only];


The actual alignment was detected with superfamily member COG2319:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.21  E-value: 3.37e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 595763372 167 GSLQLVDLASTKPgtssaPFTINAHQSDVACVSLNQPGTVVASASQKGTlIRLFDTQSKEKLVELRRGTDPAT 239
Cdd:COG2319  310 GTVRLWDLATGKL-----LRTLTGHTGAVRSVAFSPDGKTLASGSDDGT-VRLWDLATGELLRTLTGHTGAVT 376
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
167-239 3.37e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.21  E-value: 3.37e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 595763372 167 GSLQLVDLASTKPgtssaPFTINAHQSDVACVSLNQPGTVVASASQKGTlIRLFDTQSKEKLVELRRGTDPAT 239
Cdd:COG2319  310 GTVRLWDLATGKL-----LRTLTGHTGAVRSVAFSPDGKTLASGSDDGT-VRLWDLATGELLRTLTGHTGAVT 376
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 186-224 1.88e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 39.63  E-value: 1.88e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 595763372 186 FTINAHQSDVACVSLNQPGTVVASASQKGTlIRLFDTQS 224
Cdd:cd00200  129 TTLRGHTDWVNSVAFSPDGTFVASSSQDGT-IKLWDLRT 166
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
167-239 3.37e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.21  E-value: 3.37e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 595763372 167 GSLQLVDLASTKPgtssaPFTINAHQSDVACVSLNQPGTVVASASQKGTlIRLFDTQSKEKLVELRRGTDPAT 239
Cdd:COG2319  310 GTVRLWDLATGKL-----LRTLTGHTGAVRSVAFSPDGKTLASGSDDGT-VRLWDLATGELLRTLTGHTGAVT 376
WD40 COG2319
WD40 repeat [General function prediction only];
167-239 4.80e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.82  E-value: 4.80e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 595763372 167 GSLQLVDLASTKPGTssapfTINAHQSDVACVSLNQPGTVVASASQKGTlIRLFDTQSKEKLVELRRGTDPAT 239
Cdd:COG2319  226 GTVRLWDLATGKLLR-----TLTGHSGSVRSVAFSPDGRLLASGSADGT-VRLWDLATGELLRTLTGHSGGVN 292
WD40 COG2319
WD40 repeat [General function prediction only];
167-260 9.14e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 40.66  E-value: 9.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763372 167 GSLQLVDLASTKPgtssaPFTINAHQSDVACVSLNQPGTVVASASQKGTlIRLFDTQSKEKLVELRRGTDP--------- 237
Cdd:COG2319  184 GTVRLWDLATGKL-----LRTLTGHTGAVRSVAFSPDGKLLASGSADGT-VRLWDLATGKLLRTLTGHSGSvrsvafspd 257

                         90       100
                 ....*....|....*....|....*..
gi 595763372 238 ----ATLYCDkGTVHIFALKDTRLNRR 260
Cdd:COG2319  258 grllASGSAD-GTVRLWDLATGELLRT 283
WD40 COG2319
WD40 repeat [General function prediction only];
167-239 9.22e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 40.66  E-value: 9.22e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 595763372 167 GSLQLVDLASTKPgtssaPFTINAHQSDVACVSLNQPGTVVASASQKGTlIRLFDTQSKEKLVELRRGTDPAT 239
Cdd:COG2319  100 GTVRLWDLATGLL-----LRTLTGHTGAVRSVAFSPDGKTLASGSADGT-VRLWDLATGKLLRTLTGHSGAVT 166
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 186-224 1.88e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 39.63  E-value: 1.88e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 595763372 186 FTINAHQSDVACVSLNQPGTVVASASQKGTlIRLFDTQS 224
Cdd:cd00200  129 TTLRGHTDWVNSVAFSPDGTFVASSSQDGT-IKLWDLRT 166
WD40 COG2319
WD40 repeat [General function prediction only];
167-237 2.43e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 39.51  E-value: 2.43e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 595763372 167 GSLQLVDLASTKPGTssapfTINAHQSDVACVSLNQPGTVVASASQKGTlIRLFDTQSKEKLVELRRGTDP 237
Cdd:COG2319  142 GTVRLWDLATGKLLR-----TLTGHSGAVTSVAFSPDGKLLASGSDDGT-VRLWDLATGKLLRTLTGHTGA 206
WD40 COG2319
WD40 repeat [General function prediction only];
167-239 4.21e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 38.74  E-value: 4.21e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 595763372 167 GSLQLVDLASTKPGTssapfTINAHQSDVACVSLNQPGTVVASASQKGTlIRLFDTQSKEKLVELRRGTDPAT 239
Cdd:COG2319  268 GTVRLWDLATGELLR-----TLTGHSGGVNSVAFSPDGKLLASGSDDGT-VRLWDLATGKLLRTLTGHTGAVR 334
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH