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Conserved domains on  [gi|927669122|ref|NP_001300888|]
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AF4/FMR2 family member 1 isoform 3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AF-4 pfam05110
AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
 8-520 0e+00

AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


:

Pssm-ID: 461550 [Multi-domain]  Cd Length: 514  Bit Score: 545.10  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122     8 YNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDELSSRIQNMLGNYEEVKEFLSTKSHTHRLDASENR- 86
Cdd:pfam05110    1 YNEDRNLLRIREWERRNQEVQQEKDLFPENFPLFGEPYKTNKGDELSSRIQNMLGNYEEMKELITNKSNQHLVGIPKNSv 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122    87 ----LGKPKYPLIPDKGSSIPSSsFHTSVHHQSIHTPASGPLSVGnISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQD 162
Cdd:pfam05110   81 pqtpQEKPDQPFFPDKTSGLPPS-FHTSSHSQPMGPPSSSSPSVS-SSQSQKKSQARTEPAHGGHSSSGSQSSQRSQGQS 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122   163 RL--GQEGFGSSHHKKGDRRADGDHCASvtDSAPERELSPLISLPSPVPPL-SPIHSNQQTLPRTQGSSKVHGssnnsKG 239
Cdd:pfam05110  159 RSkgGQESHSSSHHKRQERREDLFSCAS--LSHSLEELSPLLSSLSSPVKPlSPSHSRQHTGSKAQNSSDHHG-----KE 231

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122   240 YCPAKSPKDLAVKVHDKETPQDSLVA-PAQPPSQTFPPPsLPSKSVAMQQKPTAYVRPMDGQDQAPSESPELKPLPEDYR 318
Cdd:pfam05110  232 YSHSKSPRDSEAGSHGPESPSTSLLAsSSQLSSQTFPPS-LPSKTSAMQQKPTAYVRPMDGQDQAPSESPELKPSPEDYH 310

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122   319 QQTFEK-TDLKVPAKAKLTKLKMPSQSVEQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSS 397
Cdd:pfam05110  311 GQSYGKlSDLKANAKAKLSKLKIPSQPLEQSLSNDVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKESQHVTS 390

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122   398 VTQNQKQYDTSSKTHSNSQQGTsSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDS 477
Cdd:pfam05110  391 GYQNQKQYDAPSKTLPTSQQGT-SMLEDDLKLSSSEDSDDDQAPEKPPPSSAPPSAPQSQPNSVASAHSSSGESGSSSDS 469

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*
gi 927669122   478 DSSSD--SESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLT 520
Cdd:pfam05110  470 ESSSEsdSESESSSSDSEANEPPRSATPEPEPPSSNKWQLDNWLN 514
AF-4_C pfam18876
AF-4 proto-oncoprotein C-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
 950-1211 1.22e-136

AF-4 proto-oncoprotein C-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


:

Pssm-ID: 465894  Cd Length: 262  Bit Score: 415.61  E-value: 1.22e-136
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122   950 SKPGKPQVKFDKQQ--ADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSKSAYSVYSETVDLIK 1027
Cdd:pfam18876    1 SKPRRPQLKFEDRQhsADYYMQEAKKLKHKADALSDKFGKAFKYLDAALSFIECGIAMESDPQEAKSPYTMYSETVELIK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122  1028 FIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFRCKKDIAIKYSRTLNKHFESSSKVAQAPSPCIARSTGTPSPLSP 1107
Cdd:pfam18876   81 YVMKLKNFTDPSATTAEKIFAVLCLRCQSLLYMAMFRLKKDTAIKYSRTLNEHFKNSSKVAQAPSPCVAKSTGTPSPLSP 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122  1108 MPSPASSVgsQSSAGSVGSSGVAATISTPVTIQNMTSSYVTITSHVLTAFDLWEQAEALTRKNKEFFARLSTNVCTLALN 1187
Cdd:pfam18876  161 MPSPASSV--SSQSGSSGSSGSSSSVSIPQRIHQMASSYVNITSNFLYAYEIWEQAEALARENKEFFAELDTVMGPLALN 238

                          250       260
                   ....*....|....*....|....
gi 927669122  1188 SSLVDLVHYTRQGFQQLQELTKTP 1211
Cdd:pfam18876  239 SSMTELVRYTRQGLHWLRLDAKLP 262
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 526-793 8.74e-07

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.79  E-value: 8.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122  526 AAPPEGPRSTePPRRHPESKGSSDSATSQEHSESKDP--------------PPKSSSKAPRAPPEAPHPGKRSCQKSPAQ 591
Cdd:PHA03247 2769 PAPPAAPAAG-PPRRLTRPAVASLSESRESLPSPWDPadppaavlapaaalPPAASPAGPLPPPTSAQPTAPPPPPGPPP 2847

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122  592 ----------------QEPPQRQTVGTkqPKKPVKASARAGSRTSLQGEREPGLLPYGS--RDQTSKDKPKVKTKGRPRA 653
Cdd:PHA03247 2848 pslplggsvapggdvrRRPPSRSPAAK--PAAPARPPVRRLARPAVSRSTESFALPPDQpeRPPQPQAPPPPQPQPQPPP 2925

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122  654 AASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDN----------VEDRTPEHFALVPLTESQGPP-HSGSGSRTS 722
Cdd:PHA03247 2926 PPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLgalvpgrvavPRFRVPQPAPSREAPASSTPPlTGHSLSRVS 3005

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 927669122  723 GCRQAVVVQEDSrkDRLPLPLRDTKLLSPLRDTPPPQSLMVKIT--LDLLSRIPQPPGKGSRQRKAEDKQPPA 793
Cdd:PHA03247 3006 SWASSLALHEET--DPPPVSLKQTLWPPDDTEDSDADSLFDSDSerSDLEALDPLPPEPHDPFAHEPDPATPE 3076
 
Name Accession Description Interval E-value
AF-4 pfam05110
AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
 8-520 0e+00

AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


Pssm-ID: 461550 [Multi-domain]  Cd Length: 514  Bit Score: 545.10  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122     8 YNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDELSSRIQNMLGNYEEVKEFLSTKSHTHRLDASENR- 86
Cdd:pfam05110    1 YNEDRNLLRIREWERRNQEVQQEKDLFPENFPLFGEPYKTNKGDELSSRIQNMLGNYEEMKELITNKSNQHLVGIPKNSv 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122    87 ----LGKPKYPLIPDKGSSIPSSsFHTSVHHQSIHTPASGPLSVGnISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQD 162
Cdd:pfam05110   81 pqtpQEKPDQPFFPDKTSGLPPS-FHTSSHSQPMGPPSSSSPSVS-SSQSQKKSQARTEPAHGGHSSSGSQSSQRSQGQS 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122   163 RL--GQEGFGSSHHKKGDRRADGDHCASvtDSAPERELSPLISLPSPVPPL-SPIHSNQQTLPRTQGSSKVHGssnnsKG 239
Cdd:pfam05110  159 RSkgGQESHSSSHHKRQERREDLFSCAS--LSHSLEELSPLLSSLSSPVKPlSPSHSRQHTGSKAQNSSDHHG-----KE 231

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122   240 YCPAKSPKDLAVKVHDKETPQDSLVA-PAQPPSQTFPPPsLPSKSVAMQQKPTAYVRPMDGQDQAPSESPELKPLPEDYR 318
Cdd:pfam05110  232 YSHSKSPRDSEAGSHGPESPSTSLLAsSSQLSSQTFPPS-LPSKTSAMQQKPTAYVRPMDGQDQAPSESPELKPSPEDYH 310

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122   319 QQTFEK-TDLKVPAKAKLTKLKMPSQSVEQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSS 397
Cdd:pfam05110  311 GQSYGKlSDLKANAKAKLSKLKIPSQPLEQSLSNDVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKESQHVTS 390

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122   398 VTQNQKQYDTSSKTHSNSQQGTsSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDS 477
Cdd:pfam05110  391 GYQNQKQYDAPSKTLPTSQQGT-SMLEDDLKLSSSEDSDDDQAPEKPPPSSAPPSAPQSQPNSVASAHSSSGESGSSSDS 469

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*
gi 927669122   478 DSSSD--SESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLT 520
Cdd:pfam05110  470 ESSSEsdSESESSSSDSEANEPPRSATPEPEPPSSNKWQLDNWLN 514
AF-4_C pfam18876
AF-4 proto-oncoprotein C-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
 950-1211 1.22e-136

AF-4 proto-oncoprotein C-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


Pssm-ID: 465894  Cd Length: 262  Bit Score: 415.61  E-value: 1.22e-136
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122   950 SKPGKPQVKFDKQQ--ADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSKSAYSVYSETVDLIK 1027
Cdd:pfam18876    1 SKPRRPQLKFEDRQhsADYYMQEAKKLKHKADALSDKFGKAFKYLDAALSFIECGIAMESDPQEAKSPYTMYSETVELIK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122  1028 FIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFRCKKDIAIKYSRTLNKHFESSSKVAQAPSPCIARSTGTPSPLSP 1107
Cdd:pfam18876   81 YVMKLKNFTDPSATTAEKIFAVLCLRCQSLLYMAMFRLKKDTAIKYSRTLNEHFKNSSKVAQAPSPCVAKSTGTPSPLSP 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122  1108 MPSPASSVgsQSSAGSVGSSGVAATISTPVTIQNMTSSYVTITSHVLTAFDLWEQAEALTRKNKEFFARLSTNVCTLALN 1187
Cdd:pfam18876  161 MPSPASSV--SSQSGSSGSSGSSSSVSIPQRIHQMASSYVNITSNFLYAYEIWEQAEALARENKEFFAELDTVMGPLALN 238

                          250       260
                   ....*....|....*....|....
gi 927669122  1188 SSLVDLVHYTRQGFQQLQELTKTP 1211
Cdd:pfam18876  239 SSMTELVRYTRQGLHWLRLDAKLP 262
PHA03247 PHA03247
large tegument protein UL36; Provisional
 526-793 8.74e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.79  E-value: 8.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122  526 AAPPEGPRSTePPRRHPESKGSSDSATSQEHSESKDP--------------PPKSSSKAPRAPPEAPHPGKRSCQKSPAQ 591
Cdd:PHA03247 2769 PAPPAAPAAG-PPRRLTRPAVASLSESRESLPSPWDPadppaavlapaaalPPAASPAGPLPPPTSAQPTAPPPPPGPPP 2847

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122  592 ----------------QEPPQRQTVGTkqPKKPVKASARAGSRTSLQGEREPGLLPYGS--RDQTSKDKPKVKTKGRPRA 653
Cdd:PHA03247 2848 pslplggsvapggdvrRRPPSRSPAAK--PAAPARPPVRRLARPAVSRSTESFALPPDQpeRPPQPQAPPPPQPQPQPPP 2925

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122  654 AASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDN----------VEDRTPEHFALVPLTESQGPP-HSGSGSRTS 722
Cdd:PHA03247 2926 PPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLgalvpgrvavPRFRVPQPAPSREAPASSTPPlTGHSLSRVS 3005

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 927669122  723 GCRQAVVVQEDSrkDRLPLPLRDTKLLSPLRDTPPPQSLMVKIT--LDLLSRIPQPPGKGSRQRKAEDKQPPA 793
Cdd:PHA03247 3006 SWASSLALHEET--DPPPVSLKQTLWPPDDTEDSDADSLFDSDSerSDLEALDPLPPEPHDPFAHEPDPATPE 3076
AF4_int pfam18875
AF4 interaction motif; This short motif found in the AF4 protein interacts with AF9.
 761-775 1.31e-03

AF4 interaction motif; This short motif found in the AF4 protein interacts with AF9.


Pssm-ID: 436798  Cd Length: 15  Bit Score: 37.02  E-value: 1.31e-03
                           10
                   ....*....|....*
gi 927669122   761 LMVKITLDLLSRIPQ 775
Cdd:pfam18875    1 LVVKIDLSLLSRVPQ 15
 
Name Accession Description Interval E-value
AF-4 pfam05110
AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
 8-520 0e+00

AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


Pssm-ID: 461550 [Multi-domain]  Cd Length: 514  Bit Score: 545.10  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122     8 YNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDELSSRIQNMLGNYEEVKEFLSTKSHTHRLDASENR- 86
Cdd:pfam05110    1 YNEDRNLLRIREWERRNQEVQQEKDLFPENFPLFGEPYKTNKGDELSSRIQNMLGNYEEMKELITNKSNQHLVGIPKNSv 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122    87 ----LGKPKYPLIPDKGSSIPSSsFHTSVHHQSIHTPASGPLSVGnISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQD 162
Cdd:pfam05110   81 pqtpQEKPDQPFFPDKTSGLPPS-FHTSSHSQPMGPPSSSSPSVS-SSQSQKKSQARTEPAHGGHSSSGSQSSQRSQGQS 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122   163 RL--GQEGFGSSHHKKGDRRADGDHCASvtDSAPERELSPLISLPSPVPPL-SPIHSNQQTLPRTQGSSKVHGssnnsKG 239
Cdd:pfam05110  159 RSkgGQESHSSSHHKRQERREDLFSCAS--LSHSLEELSPLLSSLSSPVKPlSPSHSRQHTGSKAQNSSDHHG-----KE 231

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122   240 YCPAKSPKDLAVKVHDKETPQDSLVA-PAQPPSQTFPPPsLPSKSVAMQQKPTAYVRPMDGQDQAPSESPELKPLPEDYR 318
Cdd:pfam05110  232 YSHSKSPRDSEAGSHGPESPSTSLLAsSSQLSSQTFPPS-LPSKTSAMQQKPTAYVRPMDGQDQAPSESPELKPSPEDYH 310

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122   319 QQTFEK-TDLKVPAKAKLTKLKMPSQSVEQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSS 397
Cdd:pfam05110  311 GQSYGKlSDLKANAKAKLSKLKIPSQPLEQSLSNDVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKESQHVTS 390

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122   398 VTQNQKQYDTSSKTHSNSQQGTsSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDS 477
Cdd:pfam05110  391 GYQNQKQYDAPSKTLPTSQQGT-SMLEDDLKLSSSEDSDDDQAPEKPPPSSAPPSAPQSQPNSVASAHSSSGESGSSSDS 469

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*
gi 927669122   478 DSSSD--SESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLT 520
Cdd:pfam05110  470 ESSSEsdSESESSSSDSEANEPPRSATPEPEPPSSNKWQLDNWLN 514
AF-4_C pfam18876
AF-4 proto-oncoprotein C-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
 950-1211 1.22e-136

AF-4 proto-oncoprotein C-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


Pssm-ID: 465894  Cd Length: 262  Bit Score: 415.61  E-value: 1.22e-136
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122   950 SKPGKPQVKFDKQQ--ADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSKSAYSVYSETVDLIK 1027
Cdd:pfam18876    1 SKPRRPQLKFEDRQhsADYYMQEAKKLKHKADALSDKFGKAFKYLDAALSFIECGIAMESDPQEAKSPYTMYSETVELIK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122  1028 FIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFRCKKDIAIKYSRTLNKHFESSSKVAQAPSPCIARSTGTPSPLSP 1107
Cdd:pfam18876   81 YVMKLKNFTDPSATTAEKIFAVLCLRCQSLLYMAMFRLKKDTAIKYSRTLNEHFKNSSKVAQAPSPCVAKSTGTPSPLSP 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122  1108 MPSPASSVgsQSSAGSVGSSGVAATISTPVTIQNMTSSYVTITSHVLTAFDLWEQAEALTRKNKEFFARLSTNVCTLALN 1187
Cdd:pfam18876  161 MPSPASSV--SSQSGSSGSSGSSSSVSIPQRIHQMASSYVNITSNFLYAYEIWEQAEALARENKEFFAELDTVMGPLALN 238

                          250       260
                   ....*....|....*....|....
gi 927669122  1188 SSLVDLVHYTRQGFQQLQELTKTP 1211
Cdd:pfam18876  239 SSMTELVRYTRQGLHWLRLDAKLP 262
PHA03247 PHA03247
large tegument protein UL36; Provisional
 526-793 8.74e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.79  E-value: 8.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122  526 AAPPEGPRSTePPRRHPESKGSSDSATSQEHSESKDP--------------PPKSSSKAPRAPPEAPHPGKRSCQKSPAQ 591
Cdd:PHA03247 2769 PAPPAAPAAG-PPRRLTRPAVASLSESRESLPSPWDPadppaavlapaaalPPAASPAGPLPPPTSAQPTAPPPPPGPPP 2847

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122  592 ----------------QEPPQRQTVGTkqPKKPVKASARAGSRTSLQGEREPGLLPYGS--RDQTSKDKPKVKTKGRPRA 653
Cdd:PHA03247 2848 pslplggsvapggdvrRRPPSRSPAAK--PAAPARPPVRRLARPAVSRSTESFALPPDQpeRPPQPQAPPPPQPQPQPPP 2925

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122  654 AASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDN----------VEDRTPEHFALVPLTESQGPP-HSGSGSRTS 722
Cdd:PHA03247 2926 PPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLgalvpgrvavPRFRVPQPAPSREAPASSTPPlTGHSLSRVS 3005

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 927669122  723 GCRQAVVVQEDSrkDRLPLPLRDTKLLSPLRDTPPPQSLMVKIT--LDLLSRIPQPPGKGSRQRKAEDKQPPA 793
Cdd:PHA03247 3006 SWASSLALHEET--DPPPVSLKQTLWPPDDTEDSDADSLFDSDSerSDLEALDPLPPEPHDPFAHEPDPATPE 3076
PHA03247 PHA03247
large tegument protein UL36; Provisional
 523-760 5.53e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.09  E-value: 5.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122  523 SQPAAPPEGPRSTEPPRRhPESkgSSDSATSQEHSESKDPPPKSSSKAPrAPPEAPHPGKRSCQKSPAQQEPPQRQTVGT 602
Cdd:PHA03247 2571 PRPAPRPSEPAVTSRARR-PDA--PPQSARPRAPVDDRGDPRGPAPPSP-LPPDTHAPDPPPPSPSPAANEPDPHPPPTV 2646

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122  603 KQPKKPVKASarAGSRTSL-QGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSK 681
Cdd:PHA03247 2647 PPPERPRDDP--APGRVSRpRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPG 2724

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 927669122  682 ALSGPEpakdnvedrtpehfALVPLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQS 760
Cdd:PHA03247 2725 PAAARQ--------------ASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVA 2789
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
527-691 3.41e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 44.84  E-value: 3.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122  527 APPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRScQKSPAQQEPPQRQTVGTKQPK 606
Cdd:PRK07003  366 GAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRA-EAPPAAPAPPATADRGDDAAD 444

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122  607 KPVKASARAGSRTSL-----------QGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSS 675
Cdd:PRK07003  445 GDAPVPAKANARASAdsrcderdaqpPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAA 524

                         170
                  ....*....|....*.
gi 927669122  676 LPAPSKALSGPEPAKD 691
Cdd:PRK07003  525 AAPPAPEARPPTPAAA 540
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
522-702 9.15e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 43.33  E-value: 9.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122  522 VSQPAAPPEGPRSTEPPRRHPE-----SKGSSDSATSQEHSESKDPPPKSSSKAPR-----------APPEAPHPGKRSC 585
Cdd:PRK12323  382 VAQPAPAAAAPAAAAPAPAAPPaapaaAPAAAAAARAVAAAPARRSPAPEALAAARqasargpggapAPAPAPAAAPAAA 461

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122  586 QKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPP 665
Cdd:PRK12323  462 ARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFETL 541

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 927669122  666 SSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFA 702
Cdd:PRK12323  542 APAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFD 578
AF4_int pfam18875
AF4 interaction motif; This short motif found in the AF4 protein interacts with AF9.
 761-775 1.31e-03

AF4 interaction motif; This short motif found in the AF4 protein interacts with AF9.


Pssm-ID: 436798  Cd Length: 15  Bit Score: 37.02  E-value: 1.31e-03
                           10
                   ....*....|....*
gi 927669122   761 LMVKITLDLLSRIPQ 775
Cdd:pfam18875    1 LVVKIDLSLLSRVPQ 15
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 523-703 1.74e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.67  E-value: 1.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122  523 SQPAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGT 602
Cdd:PRK07764  634 AAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQ 713

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122  603 KQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVktKGRPRAAASNEPKPAVPPSSEKKkhksslPAPSKA 682
Cdd:PRK07764  714 ADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPA--QPPPPPAPAPAAAPAAAPPPSPP------SEEEEM 785

                         170       180
                  ....*....|....*....|.
gi 927669122  683 LSGPEPAKDNVEDRTPEHFAL 703
Cdd:PRK07764  786 AEDDAPSMDDEDRRDAEEVAM 806
dnaA PRK14086
chromosomal replication initiator protein DnaA;
524-689 2.68e-03

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 41.73  E-value: 2.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122  524 QPAAPPEGPRSTEPPRRHPESKGSSDSATSQEhSESKDPPPKSSSKAPRAPPEAP---HPGKRSCQKSPAQQEPPQRQTV 600
Cdd:PRK14086   94 EPAPPPPHARRTSEPELPRPGRRPYEGYGGPR-ADDRPPGLPRQDQLPTARPAYPayqQRPEPGAWPRAADDYGWQQQRL 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122  601 GTKQPKKPvkASARAGSRTSLQGEREPGL----LPYGSRDQT----SKDKPKVKTKGRPRAAASNE------PKPAVPPS 666
Cdd:PRK14086  173 GFPPRAPY--ASPASYAPEQERDREPYDAgrpeYDQRRRDYDhprpDWDRPRRDRTDRPEPPPGAGhvhrggPGPPERDD 250

                         170       180
                  ....*....|....*....|...
gi 927669122  667 SEKKKHKSSLPAPSKALSGPEPA 689
Cdd:PRK14086  251 APVVPIRPSAPGPLAAQPAPAPG 273
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 525-616 3.38e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 41.62  E-value: 3.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122  525 PAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSeskdPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQ 604
Cdd:PRK14951  389 PAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAA----PPAPVAAPAAAAPAAAPAAAPAAVALAPAPPAQAAPETVAIPV 464

                          90
                  ....*....|..
gi 927669122  605 PKKPVKASARAG 616
Cdd:PRK14951  465 RVAPEPAVASAA 476
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 513-758 4.83e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 41.31  E-value: 4.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122  513 WQLDNWLTKVSQPAA-------------PPEGPRSTEPPRRHPESKGSSD---------------SATSQEHSESKDP-- 562
Cdd:PHA03307  170 RQAALPLSSPEETARapssppaepppstPPAAASPRPPRRSSPISASASSpapapgrsaaddagaSSSDSSSSESSGCgw 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122  563 --------PPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPYGS 634
Cdd:PHA03307  250 gpenecplPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSST 329

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122  635 RDQTSKDKPKVKTKGRP--RAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDnvedrtpehfALVPLTESQGP 712
Cdd:PHA03307  330 SSSSESSRGAAVSPGPSpsRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRR----------RARAAVAGRAR 399

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 927669122  713 PHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRD-TKLLSPLRDTPPP 758
Cdd:PHA03307  400 RRDATGRFPAGRPRPSPLDAGAASGAFYARYPLlTPSGEPWPGSPPP 446
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
523-713 6.00e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.01  E-value: 6.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122  523 SQPAAPPEGPRSTEPPRRHPESkgssdsatsqehseSKDPPPKSSSKAPRAPPEAPHPGkrscqkspaqqePPQRQTVGT 602
Cdd:PRK12323  372 AGPATAAAAPVAQPAPAAAAPA--------------AAAPAPAAPPAAPAAAPAAAAAA------------RAVAAAPAR 425

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122  603 KQPKKPVKASARAGSRTSLQGEREPGLLPygsrdqtskdkPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPskA 682
Cdd:PRK12323  426 RSPAPEALAAARQASARGPGGAPAPAPAP-----------AAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAP--A 492

                         170       180       190
                  ....*....|....*....|....*....|.
gi 927669122  683 LSGPEPAKDnvedrTPEHFALVPLTESQGPP 713
Cdd:PRK12323  493 DDDPPPWEE-----LPPEFASPAPAQPDAAP 518
PHA03325 PHA03325
nuclear-egress-membrane-like protein; Provisional
 525-665 7.21e-03

nuclear-egress-membrane-like protein; Provisional


Pssm-ID: 223044  Cd Length: 418  Bit Score: 40.25  E-value: 7.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122  525 PAAPPEGPRSTEPPRRHPESKGSSDSATSQE-------HSESKDPPPKSSSKAPrAPPEAPHPGKRSCQKSP------AQ 591
Cdd:PHA03325  260 SAFMLNSSLPTSAPKRRSRRAGAMRAAAGETadladddGSEHSDPEPLPASLPP-PPVRRPRVKHPEAGKEEpdgarnAE 338

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 927669122  592 QEPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPP 665
Cdd:PHA03325  339 AKEPAQPATSTSSKGSSSAQNKDSGSTGPGSSLAAASSFLEDDDFGSPPLDLTTSLRHMPSPSVTSAPEPPSIP 412
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 532-705 7.96e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.35  E-value: 7.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122  532 PRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKA 611
Cdd:PRK07764  376 ARLERLERRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPS 455

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122  612 SARAGSrtslqgerepgllpyGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSekkkhksslPAPSKALSGPEPAkD 691
Cdd:PRK07764  456 PPPAAA---------------PSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAA---------PAAPAAPAGADDA-A 510

                         170
                  ....*....|....
gi 927669122  692 NVEDRTPEHFALVP 705
Cdd:PRK07764  511 TLRERWPEILAAVP 524
DUF4045 pfam13254
Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. ...
 526-665 8.40e-03

Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. This domain family is found in bacteria and eukaryotes, and is typically between 384 and 430 amino acids in length.


Pssm-ID: 433066 [Multi-domain]  Cd Length: 415  Bit Score: 40.15  E-value: 8.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122   526 AAPPEGPRSTEPPRRHpeSKGSSDSATSQEHSESKDPPPKSSSkaPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQP 605
Cdd:pfam13254  202 EVTPVGLMRSPAPGGH--SKSPSVSGISADSSPTKEEPSEEAD--TLSTDKEQSPAPTSASEPPPKTKELPKDSEEPAAP 277

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 927669122   606 KKPVKASARA------GSRTSLQGEREPGLLPYGSRdqTSKDKPKVKTkgrPRAAASNEPKPAVPP 665
Cdd:pfam13254  278 SKSAEASTEKkepdteSSPETSSEKSAPSLLSPVSK--ASIDKPLSSP---DRDPLSPKPKPQSPP 338
PHA03247 PHA03247
large tegument protein UL36; Provisional
 525-899 8.76e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 8.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122  525 PAAPPEGPRSTEPPRRhPESKGSSDSATSQEHSES--------------KDPPPKSSSKAPrAPPEAPHPGKRSCQKSPA 590
Cdd:PHA03247 2557 PAAPPAAPDRSVPPPR-PAPRPSEPAVTSRARRPDappqsarprapvddRGDPRGPAPPSP-LPPDTHAPDPPPPSPSPA 2634

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122  591 QQEPPQRQTVGTKQPKKPVKASAraGSRTSL-QGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEK 669
Cdd:PHA03247 2635 ANEPDPHPPPTVPPPERPRDDPA--PGRVSRpRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAP 2712

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122  670 KKHKSSLPAPSKALSGPEpakdnvedrtpehfALVPLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDtkll 749
Cdd:PHA03247 2713 HALVSATPLPPGPAAARQ--------------ASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAA---- 2774

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122  750 splRDTPPPQslmvkitldllsRIPQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAKKRKGeaerdcdnkkirl 829
Cdd:PHA03247 2775 ---PAAGPPR------------RLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAG------------- 2826

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 927669122  830 ekeiKSQSSSSSSSHKESSKTKPSRPS-----SQSSKKEMLPPPPVSSSSQKPAKPALKRSRREADTCGQDPPKS 899
Cdd:PHA03247 2827 ----PLPPPTSAQPTAPPPPPGPPPPSlplggSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTES 2897
PHA03247 PHA03247
large tegument protein UL36; Provisional
 568-777 9.30e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 9.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122  568 SKAPRAPPEAPHPGKrSCQKSPAQQEPPQRQTvGTKQPKKPVKASARAGSRTSLQGERE----------PGLLPYGSRDQ 637
Cdd:PHA03247 2486 ARFPFAAGAAPDPGG-GGPPDPDAPPAPSRLA-PAILPDEPVGEPVHPRMLTWIRGLEElasddagdppPPLPPAAPPAA 2563

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927669122  638 TSKDKPKVKTKGRPR--AAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQGPPHS 715
Cdd:PHA03247 2564 PDRSVPPPRPAPRPSepAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPP 2643

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 927669122  716 GSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPP 777
Cdd:PHA03247 2644 PTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPP 2705
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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