second galactose/rhamnose binding lectin domain found in Caenorhabditis elegans protein EVA-1, human protein EVA-1 homolog C and similar proteins; The family includes Caenorhabditis elegans protein EVA-1 and its homologs, such as human protein EVA-1 homolog C (also known as C21orf63). EVA-1 functions as an UNC-40 coreceptor to enhance attraction to the MADD-4 guidance cue in C. elegans. It also acts as a receptor for slt-1 and is required for the guidance of the AVM pioneer axon to the ventral nerve cord. Human C21orf63 is a type-1 transmembrane heparin-binding protein. Members in this family contain two tandem galactose/rhamnose-binding lectin domains. This model corresponds to the second one. Due to the lack of rhamnose-binding key residues, the second galactose/rhamnose-binding domains of EVA-1 does not form a binding pocket for rhamnose.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941355880  57 KNKTVCENQELKLHCHESKFLNIYSAAYGRRTQQRDICSSGAELLPPFDCLSYTALQVLSRRCYGKQRCKVLVDNYHFGS 136
Cdd:cd22829    2 KSKVVCEGEKLRLSCKPSSRLAIYSASYGRTLEGSVECPSTPKGDPDEECLSDVALETVMKRCHGKRRCSLTADSETFGD 81

                         90
                 ....*....|....*...
gi 941355880 137 PCLPGVKKYLTVAYACVP 154
Cdd:cd22829   82 PCPPGVRKYLKVVYTCVP 99

second galactose/rhamnose binding lectin domain found in Caenorhabditis elegans protein EVA-1, human protein EVA-1 homolog C and similar proteins; The family includes Caenorhabditis elegans protein EVA-1 and its homologs, such as human protein EVA-1 homolog C (also known as C21orf63). EVA-1 functions as an UNC-40 coreceptor to enhance attraction to the MADD-4 guidance cue in C. elegans. It also acts as a receptor for slt-1 and is required for the guidance of the AVM pioneer axon to the ventral nerve cord. Human C21orf63 is a type-1 transmembrane heparin-binding protein. Members in this family contain two tandem galactose/rhamnose-binding lectin domains. This model corresponds to the second one. Due to the lack of rhamnose-binding key residues, the second galactose/rhamnose-binding domains of EVA-1 does not form a binding pocket for rhamnose.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941355880  57 KNKTVCENQELKLHCHESKFLNIYSAAYGRRTQQRDICSSGAELLPPFDCLSYTALQVLSRRCYGKQRCKVLVDNYHFGS 136
Cdd:cd22829    2 KSKVVCEGEKLRLSCKPSSRLAIYSASYGRTLEGSVECPSTPKGDPDEECLSDVALETVMKRCHGKRRCSLTADSETFGD 81

                         90
                 ....*....|....*...
gi 941355880 137 PCLPGVKKYLTVAYACVP 154
Cdd:cd22829   82 PCPPGVRKYLKVVYTCVP 99

second galactose/rhamnose binding lectin domain found in Caenorhabditis elegans protein EVA-1, human protein EVA-1 homolog C and similar proteins; The family includes Caenorhabditis elegans protein EVA-1 and its homologs, such as human protein EVA-1 homolog C (also known as C21orf63). EVA-1 functions as an UNC-40 coreceptor to enhance attraction to the MADD-4 guidance cue in C. elegans. It also acts as a receptor for slt-1 and is required for the guidance of the AVM pioneer axon to the ventral nerve cord. Human C21orf63 is a type-1 transmembrane heparin-binding protein. Members in this family contain two tandem galactose/rhamnose-binding lectin domains. This model corresponds to the second one. Due to the lack of rhamnose-binding key residues, the second galactose/rhamnose-binding domains of EVA-1 does not form a binding pocket for rhamnose.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941355880  57 KNKTVCENQELKLHCHESKFLNIYSAAYGRRTQQRDICSSGAELLPPFDCLSYTALQVLSRRCYGKQRCKVLVDNYHFGS 136
Cdd:cd22829    2 KSKVVCEGEKLRLSCKPSSRLAIYSASYGRTLEGSVECPSTPKGDPDEECLSDVALETVMKRCHGKRRCSLTADSETFGD 81

                         90
                 ....*....|....*...
gi 941355880 137 PCLPGVKKYLTVAYACVP 154
Cdd:cd22829   82 PCPPGVRKYLKVVYTCVP 99

galactose/rhamnose binding lectin domain found in Toxopneustes pileolus rhamnose-binding lectin SUL-I and similar proteins; SUL-I is a galactose/rhamnose-binding lectin with mitogenic, chemotactic, and cytotoxic activity. These activities can be triggered by binding of the lectin to specific carbohydrate chains on target cells. SUL-I may be involved in self-defense against invading microorganisms. SUL-I is composed of three distinctive domains with a folding structure similar to galactose/rhamnose-binding lectin domain found in proteins such as mammalian latrophilins, Oncorhynchus keta L-rhamnose-binding lectins (CSLs), and Silurus asotus rhamnose-binding lectin (SAL). The family also includes Heliocidaris crassispina D-galactoside-specific lectin, also known as sea urchin egg lectin or SUEL, and Echinometra lucunter L-rhamnose-binding lectin ELEL-1, both of which contain only one galactose/rhamnose-binding lectin domain. SUEL binds D-galactoside. It may play an important role in the activation of eggs triggered by fertilization, or in their subsequent differentiation. The dimeric form is essential for hemagglutination activity of SUEL. ELEL-1 is a rhamnose-binding lectin that also binds alpha-D-melibiose, alpha-D-lactose, beta-D-lactose, methyl-alpha-D-galactopyranoside, methyl-beta-D--galactopyranoside and D-galactose, but not D-arabinose, L-fucose, D-glucose, D-mannose, D-maltose, D-sucrose, N-acetyl-D-galactosamine, N-acetyl-D-glucosamine, N-acetyl-D-mannosamine-D-xylose, or by glycoproteins orosomucoid, thyroglobulin, ovomucoid and porcine stomach mucin. It shows cation-independent hemagglutinating activity against rabbit and human erythrocytes. ELEL-1 agglutinates cells of Gram-positive bacterial species S. aureus but not those of Gram-negative E. coli.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941355880  59 KTVCENQELKLHCHESKFLNIYSAAYGRRTqqRDICSSGAelLPPFDCLSYTALQVLSRRCYGKQRCKVLVDNYHFGSPC 138
Cdd:cd22827    1 KRVCEGQTLTISCPAGKVIDIVSANYGRTD--SSTCPSGG--IKNTNCRASNSLSIVRNRCNGKRSCSVKASNSVFGDPC 76

                         90
                 ....*....|....
gi 941355880 139 lPGVKKYLTVAYAC 152
Cdd:cd22827   77 -VGTYKYLEVRYRC 89

first galactose/rhamnose binding lectin domain found in Caenorhabditis elegans protein EVA-1, human protein EVA-1 homolog C and similar proteins; The family includes Caenorhabditis elegans protein EVA-1 and its homologs, such as human protein EVA-1 homolog C (also known as C21orf63). EVA-1 functions as an UNC-40 coreceptor to enhance attraction to the MADD-4 guidance cue in C. elegans. It also acts as a receptor for slt-1 and is required for the guidance of the AVM pioneer axon to the ventral nerve cord. Human C21orf63 is a type-1 transmembrane heparin-binding protein. Both human C21orf63 is a type-1 transmembrane heparin-binding protein. Members in this family contain two tandem galactose/rhamnose-binding lectin domains. This model corresponds to the first one.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941355880  59 KTVCENQELKLHCHESKFLNIYSAAYGRRTQQRDICSSGAELLPPF-----DCLSYTALQVLSRRCYGKQRCKVLVDNYH 133
Cdd:cd22828    5 RHACDGEELTLRCPPNTTISIQSAFYGRSVPSAQLCPSQSGPASSTsledtNCLAPTALQKVVEECQKKRSCRLLVSSRT 84

                         90       100
                 ....*....|....*....|..
gi 941355880 134 FGS-PClPGVKKYLTVAYACVP 154
Cdd:cd22828   85 FGLdPC-PGTSKYLEVAYKCRP 105

second galactose/rhamnose binding lectin domain found in Scomberomorus niphonius L-rhamnose-binding lectin (SML) and similar proteins; SML is a rhamnose-binding lectin that also binds melibiose, raffinose, D-galactose, L-arabinose, D-fucose, maltose and D-glucose with decreasing affinity. It does not bind D-arabinose, L-fucose, lactose, xylose or 2-deoxy-D-galactose. SML shows strong hemagglutinating activity against rabbit erythrocytes. SML contains two tandem galactose/rhamnose-binding lectin domains. This model corresponds to the second one.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941355880  61 VCENQELKLHCHESKFLNIYSAAYGRRTQQrdICSSGAellPPF-----DCLSYTALqvLSRRCYGKQRCKVLVDNYHFG 135
Cdd:cd22835    4 ACEGSLAHLKCDEGQVISVYGADYGRRDKT--TCSFGR---PPSqiqnvECSNPTDK--VAERCNGKNSCSIKASNSVFG 76

                         90
                 ....*....|....*..
gi 941355880 136 SPClPGVKKYLTVAYAC 152
Cdd:cd22835   77 DPC-VGTYKYLEVAYTC 92

galactose/rhamnose binding lectin domain found in Caenorhabditis elegans latrophilin-like protein 2 (LAT2) and similar proteins; LAT2 may have a role in pharyngeal pumping during feeding. It contains a galactose/rhamnose binding lectin domain at the N-terminal region. Due to the lack of rhamnose-binding key residues, the galactose/rhamnose-binding domains of LAT2 does not form a binding pocket for rhamnose. Therefore, LAT2 is unlikely to act as a rhamnose-binding lectin.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941355880  58 NKTVCENQELKLHCHESKFLNIYSAAYGRrTQQRDICSSGAELLPPFdCLSYTALQVLSRRCYGKQRCKVLVDNYHF-GS 136
Cdd:cd22840    3 SSVACEGDPFEISCPSGQRIKVDYASYGA-IGTRSTCGDSVSPAGET-CSAPNSLQTMRQRCQGRQSCEIRVLNSLFpND 80

                         90
                 ....*....|....*.
gi 941355880 137 PCLPGVKKYLTVAYAC 152
Cdd:cd22840   81 PCPGTSKKYLEYRYRC 96

first and second galactose/rhamnose binding lectin domain found in Oncorhynchus keta L-rhamnose-binding lectin CSL3 and similar proteins; The family includes a group of L-rhamnose-binding lectins, such as Oncorhynchus keta CSL1-3. CSL1 has hemagglutinating activity towards rabbit erythrocytes, but not human type B erythrocytes. CSL2 has hemagglutinating activity towards rabbit erythrocytes and human type B erythrocytes. CSL3 has hemagglutinating activity towards rabbit erythrocytes, human type A erythrocytes, human type B erythrocytes, human type O erythrocytes, and sheep erythrocytes. Their hemagglutinating activities are inhibited by smooth-type lipopolysaccharide (LPS) from different bacterial species. Members in this family contain two tandem galactose-binding lectin domains. This model corresponds to the first and second galactose/rhamnose-binding lectin domains found in Oncorhynchus keta CSL3, as well as the second galactose/rhamnose-binding lectin domain found in Oncorhynchus keta CSL2.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941355880  62 CENQELKLHCHESKfLNIYSAAYGRRtqQRDICSSG--AELLPPFDCLSYTALQVLSRRCYGKQRCKVLVDNYHFGSPCL 139
Cdd:cd22832    6 CEGSDAQLDCDGGK-IRIQRANYGRR--DHDVCSIGrpANQLTNTNCLSQSTTSKMAERCDGKSQCIVPASNSVFGDPCV 82

                         90
                 ....*....|...
gi 941355880 140 pGVKKYLTVAYAC 152
Cdd:cd22832   83 -GTYKYLDVAYTC 94

galactose/rhamnose binding lectin domain found in Caenorhabditis elegans latrophilin-like protein 1 (LAT1) and similar proteins; LAT1 plays a role in the establishment of anterior-posterior polarity in tissues during embryogenesis. It is required for the alignment of the mitotic spindles and division planes. It may have a role in cell death events and play an essential role in normal defection and oocyte fertilization. LAT1 is involved in sperm function. it operates in pharyngeal pumping during feeding. LAT1 contains a galactose/rhamnose binding lectin domain at the N-terminus.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941355880  57 KNKTVCENQELKLHCHESKFLNIYSAAYGRRTQQrdICSSGAELLPPFDCLSYTALQVLSRRCYGKQRCKVLVDN-YHFG 135
Cdd:cd22839    2 SSVIICEGDVANLSCPEGKYISIRLANYGRFSLG--VCNPSNNIDLSTTCQNDKTLPILQKSCDGKSECSFVVSNkFFFE 79

                         90
                 ....*....|....*..
gi 941355880 136 SPClPGVKKYLTVAYAC 152
Cdd:cd22839   80 DPC-PGTPKYLEATYSC 95

galactose/rhamnose binding lectin domain found in latrophilin-1 and similar proteins; Latrophilin-1 (LPHN1), also called adhesion G protein-coupled receptor L1 (ADGRL1), or calcium-independent alpha-latrotoxin receptor 1 (CIRL-1), or lectomedin-2, is a brain-specific calcium-independent receptor that mediates the effect of alpha-latrotoxin, a potent presynaptic neurotoxin from the venom of the black widow spider that induces massive neurotransmitter release from sensory and motor neurons as well as endocrine cells, leading to nerve-terminal degeneration. This model corresponds to a galactose/rhamnose-binding lectin domain found at the N-terminus of LPHN1.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941355880  56 LKNKTVCENQELKLHCHESKFLNIYSAAYGRRTQQrdICSSGAELLPPFDCLSYTALQVLSRRCYGKQRCKVLVDNYHFG 135
Cdd:cd22844    1 MRRELACEGYPIELRCPGSDVIMVENANYGRTDDK--ICDADPFQMENVQCYLPDAFKIMSQRCNNRTQCVVVAGSDAFP 78

                         90
                 ....*....|....*....
gi 941355880 136 SPClPGVKKYLTVAYACVP 154
Cdd:cd22844   79 DPC-PGTYKYLEVQYDCVP 96

first galactose/rhamnose binding lectin domain found in Oncorhynchus keta CSL1-2, Silurus asotus RBL, Scomberomorus niphonius SML and similar proteins; The family includes a group of L-rhamnose-binding lectins, such as Oncorhynchus keta CSL1 and CSL2. CSL1 has hemagglutinating activity towards rabbit erythrocytes, but not human type B erythrocytes. CSL2 has hemagglutinating activity towards rabbit erythrocytes and human type B erythrocytes. Their hemagglutinating activities are inhibited by smooth-type lipopolysaccharide (LPS) from different bacterial species. The family also includes Silurus asotus rhamnose-binding lectin (RBL) and Scomberomorus niphonius L-rhamnose-binding lectin (SML). RBL, also known as Silurus asotus (catfish) roe lectin (SAL), is a lectin that binds L-rhamnose. It also binds monosaccharides possessing steric similarity to the hydroxyl group orientation at C2 and C4 of the pyranose ring structure of L-rhamnose, such as L-mannose and L-lyxose. RBL does not require a Ca2+ ion or free thiol group for its agglutination activity. SML is a rhamnose-binding lectin that also binds melibiose, raffinose, D-galactose, L-arabinose, D-fucose, maltose, and D-glucose with decreasing affinity. It does not bind D-arabinose, L-fucose, lactose, xylose or 2-deoxy-D-galactose. SML shows strong hemagglutinating activity against rabbit erythrocytes. CSL1-2 and SML contain two tandem galactose/rhamnose-binding lectin domains. RBL contains three galactose/rhamnose-binding lectin domains. This model corresponds to the first one.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941355880  60 TVCENQEL-KLHChESKFLNIYSAAYGRRtqQRDICSSG--AELLPPFDCLSYTALQVLSRRCYGKQRCKVLVDNYHFGS 136
Cdd:cd22833    4 TTCDGNNVhRLSC-DTGVINVQSALYGRT--DSETCSEGrpPEQLTNTQCSQSGTLDLLKNRCDGKKVCELNTNDFRTSD 80

                         90
                 ....*....|....*...
gi 941355880 137 PClPGVKKYLTVAYACVP 154
Cdd:cd22833   81 PC-PGTYKYLQTNYTCLP 97

second galactose/rhamnose binding lectin domain found in Oncorhynchus keta CSL1 and similar proteins; The family includes a group of L-rhamnose-binding lectins, such as Oncorhynchus keta CSL1. CSL1 has hemagglutinating activity towards rabbit erythrocytes, but not human type B erythrocytes. Its hemagglutinating activity is inhibited by smooth-type lipopolysaccharide (LPS) from Klebsiella pneumoniae, Escherichia coli K-235, Shigella flexneri 1A, Aeromonas salmonicida and Salmonella minnesota and rough-type LPS from S. flexneri, but not by rough-type LPS from E. coli K12 and E. coli EH100. CSL1 agglutinates E. coli K12 and Bacillus subtilis. CSL1 contains two tandem galactose-binding lectin domains. This model corresponds to the second one.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941355880  62 CENQELKLHCHESkFLNIYSAAYGRRTqqRDICSSG--AELLPPFDCLSYTALQVLSRRCYGKQRCKVLVDNYhFGSPCL 139
Cdd:cd22834    8 CEGSPVSLDCGPD-VIKIYDANYGRRD--STTCSHGrpESQLTNTNCYLPETTKVMSERCNGKSLCDLLASNV-VTDPCY 83

                         90
                 ....*....|...
gi 941355880 140 pGVKKYLTVAYAC 152
Cdd:cd22834   84 -GTYKYLEVSYSC 95

galactose binding lectin domain found in polycystic kidney disease protein 1-like 2 (polycystin-1L2) and similar proteins; Polycystin-1L2 is a novel G-protein-coupled receptor that may function as an ion-channel regulator. This model corresponds to a galactose/rhamnose-binding lectin domain found at the N-terminal region of polycystin-1L2. Due to the lack of rhamnose-binding key residues, the galactose/rhamnose-binding domains of Polycystin-1L2 does not form a binding pocket for rhamnose. Therefore, Polycystin-1L2 is unlikely to act as a rhamnose-binding lectin.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941355880  61 VCENQELKLHCHESKFLNIYSAAYGRRTqqRDICSSGAELLPPF---DCLSYTALQVLSRRCYGKQRCKVLVDNYHFGSP 137
Cdd:cd22831    5 ACEDYNATLQCGSGQVIEIDDSFYGRNT--PHYCRSENPSPPTDsqeRCSWVDVRDLVAAQCHGLQVCQIPADPSSFGEP 82

                         90
                 ....*....|....*
gi 941355880 138 ClPGVKKYLTVAYAC 152
Cdd:cd22831   83 C-PELGSYLSVEYHC 96

galactose/rhamnose binding lectin-like domain found in Plasmodium falciparum P113 and similar proteins; P113 is an abundant glycosylphosphatidylinositol (GPI)-anchored merozoite surface protein that tethers the RH5:CyRPA:RIPR complex to the merozoite surface. The N-terminal region of P113 contains two closely interacting domains, which resemble the galactose/rhamnose-binding lectin domains found in proteins such as sea urchin egg lectin (SUEL), plant beta-galactosidases, mammalian latrophilins, and catfish rhamnose-binding lectin (SAL) eggs. Due to the lack of rhamnose-binding key residues, the galactose/rhamnose binding lectin-like domains of P113 do not form a binding pocket for rhamnose. Therefore, P113 is unlikely to act as a rhamnose-binding lectin. This model corresponds to galactose/rhamnose binding lectin-like domain of P113.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941355880  56 LKNKTVCENQELKLHCHESKFLNIYSAAYGRrtQQRDICSSGAELLPPFDCLSYtalqvLSRRCYGKQRCKVLVDNYHFG 135
Cdd:cd22843    1 PHTAFVCFGQEVTIHCPGDGNISIKSATYGY--NNSNVCIYCNSFNCDKDITSP-----VNKKCCGKNTCVLTVSDILEG 73

                         90
                 ....*....|....*..
gi 941355880 136 SPClPGVKKYLTVAYAC 152
Cdd:cd22843   74 NPC-GIGNSYIRVVYTC 89