BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850023733  15 FSTALRSLINNPQYSDICFVVGQERQEVFAHRCLLACRCNFFQRLLGPGV-----PSPVVLSTVPAEAFLAVLEFLYTNS 89
Cdd:cd18294     1 FAADMKSLINNPEFSDVKFLVGPERQEIFAHKCILAARCEVFRAMFLTGPqkestQSPLVLSDIEPEVFRAVLEFIYTNC 80

                          90
                  ....*....|....*....
gi 1850023733  90 VKLHQHSVLEVLTTAVEYG 108
Cdd:cd18294    81 VTLSNHTVIEVLAAAVEYG 99

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850023733  15 FSTALRSLINNPQYSDICFVVGQERQEVFAHRCLLACRCNFFQRLLGPGV-----PSPVVLSTVPAEAFLAVLEFLYTNS 89
Cdd:cd18294     1 FAADMKSLINNPEFSDVKFLVGPERQEIFAHKCILAARCEVFRAMFLTGPqkestQSPLVLSDIEPEVFRAVLEFIYTNC 80

                          90
                  ....*....|....*....
gi 1850023733  90 VKLHQHSVLEVLTTAVEYG 108
Cdd:cd18294    81 VTLSNHTVIEVLAAAVEYG 99

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850023733   30 DICFVVGQerQEVFAHRCLLACRCNFFQRLL----GPGVPSPVVLSTVPAEAFLAVLEFLYTNSVKLHQHSVLEVLTTAV 105
Cdd:smart00225   1 DVTLVVGG--KKFHAHKAVLAAHSPYFKALFssdfKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELAD 78

                   ..
gi 1850023733  106 EY 107
Cdd:smart00225  79 YL 80

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850023733  133 LQVAVTFGLGSLQERCIAFIEAHSQEALRTRGFLELSATALLPVLRSDKLCVD-ETELVQAARSWARVGaavlEQPVAEV 211
Cdd:smart00875   5 RRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSsEEEVFEAVLRWVKHD----PEKRREH 80

                           90
                   ....*....|....*...
gi 1850023733  212 AAPVVRELRLALLAPAEL 229
Cdd:smart00875  81 LPELLEHVRLPLLSPDYL 98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850023733  15 FSTALRSLINNPQYSDICFVVGQERQEVFAHRCLLACRCNFFQRLLGPGV-----PSPVVLSTVPAEAFLAVLEFLYTNS 89
Cdd:cd18294     1 FAADMKSLINNPEFSDVKFLVGPERQEIFAHKCILAARCEVFRAMFLTGPqkestQSPLVLSDIEPEVFRAVLEFIYTNC 80

                          90
                  ....*....|....*....
gi 1850023733  90 VKLHQHSVLEVLTTAVEYG 108
Cdd:cd18294    81 VTLSNHTVIEVLAAAVEYG 99

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850023733  15 FSTALRSLINNPQYSDICFVVgqERQEVFAHRCLLACRCNFFQRLLGPGV----PSPVVLSTVPAEAFLAVLEFLYTNSV 90
Cdd:cd18287     9 LSEDIGALFLNEEYSDVTFVV--EEKRFPAHRVILAARSEYFRALLYGGMresqQSEIELKDTNAEAFKALLKYIYTGRL 86

                          90       100
                  ....*....|....*....|.
gi 1850023733  91 KLH---QHSVLEVLTTAVEYG 108
Cdd:cd18287    87 TLTdlkEDVLLDVLGLAHQYG 107

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850023733 124 LDVELVCEALQVAVTFGLGSLQERCIAFIEAHSQEALRTRGFLELSATALLPVLRSDKLCVDETELVQAARSWARVgaav 203
Cdd:cd14822     1 LNIRNVCLIYDVASLYSLDDLCQTCCQFMDRNAQEVLSSEGFLTLSKSALKELLSRDSFCAPEVDIFNAVRRWCEH---- 76

                          90       100
                  ....*....|....*....|....*.
gi 1850023733 204 lEQPVAEVAAPVVRELRLALLAPAEL 229
Cdd:cd14822    77 -NPDSKEDAKEILEAVRLPLMSLTEL 101

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850023733  19 LRSLINNPQYSDICFVVgQERQEVFAHRCLLACRCNFFQRLLGpgVPSPVVL-STVPAEAFLAVLEFLYTNSVKLHQHSV 97
Cdd:cd18299     3 LRNLLHSPSCADVVFIL-QGGVRIFAHRIVLAAASSVFADLFL--MMTVVTLdSDITPEAFRRVLEFLYTGVLDENEDDL 79

                  ....*..
gi 1850023733  98 LEVLTTA 104
Cdd:cd18299    80 KELKDAA 86

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1850023733  20 RSLINNPQYSDICFVVgqERQEVFAHRCLLACRCNFFQRLLGPG----VPSPVVLSTVPAEAFLAVLEFLYTNSVKL 92
Cdd:cd18300     1 KLFLNKGLFSDVTFIV--EDGTIPAHKALLVARCDVMAAMFGGNfresSAKEVELPGVSKETFLALLEYLYTDQAPI 75

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850023733  24 NNPQYSDICFVVGQerQEVFAHRCLLACRCNFFQRLLGPGVP----SPVVLSTVPAEAFLAVLEFLYTNSVKLHQhSVLE 99
Cdd:pfam00651   6 EQGELCDVTLVVGD--KEFRAHKAVLAACSPYFKALFSGQESessvSEITLDDVSPEDFEALLEFMYTGKLISEE-NVDD 82

                  ....*...
gi 1850023733 100 VLTTAVEY 107
Cdd:pfam00651  83 LLAAADKL 90

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850023733  22 LINNPQYSDICFVVgqERQEVFAHRCLLACRCNFFQRLL--GPGVPSP--VVLSTVPAEAFLAVLEFLYTNSVKLHQHSV 97
Cdd:cd18297     6 YVNNPEMSDVTFLV--EGRPFYAHKIVLVTASDRFKSMLssGSTEAQTpvIEIPDIRYDIFQLMMQYLYTGGVESLDVAQ 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1850023733  98 LEVLttaveygleelrelclefvvkvldvelvcEALQVAVTFGLGSLQERCIAFIEAH 155
Cdd:cd18297    84 DDAL-----------------------------ELLRAASFFQLDGLKRHCEILLSQQ 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850023733  22 LINNPQYSDICFVVGQE--RQEVFAHRCLLACRCNFFQRLLGPGVPSP---VVLSTVPAEAFLAVLEFLYTNSVKLHQHS 96
Cdd:cd18281    16 LFNNETLSDVHFIVGKGdnEQRIPAHKFVLSIGSAVFDAMFNGGMATTsaeIELPDVEPAAFLALLRFLYSDEVQIGPET 95

                          90
                  ....*....|.
gi 1850023733  97 VLEVLTTAVEY 107
Cdd:cd18281    96 VMTTLYTAKKY 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850023733  22 LINNPQYSDICFVVGQER--------QEVFAHRCLLACRCNFFQRLLGPGVPSP---VVLSTVPAEAFLAVLEFLYTNSV 90
Cdd:cd18346    16 LFNNELLSDVRFVVGKGRprgpgpgaQRIPAHRFVLAAGSAVFDAMFNGGMATTsaeIELPDVEPAAFLALLRFLYSDEV 95

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1850023733  91 KLHQHSVLEVLTTAVEYGLEELRELCLEFVVKVL 124
Cdd:cd18346    96 QIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHL 129

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1850023733  30 DICFVVGQERqeVFAHRCLLACRCNFFQRLLGPGVPSP--------VVLSTVPAEAFLAVLEFLYTNS 89
Cdd:cd18301    20 DVVFQVGGKT--FPAHKFILASRSDYFRKLFLSSLLTSedavgcdvVHIEKVPPEIFEQLLQFIYTDT 85

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850023733  16 STALRSLINNPQ--YSDICFVVGQERqEVFAHRCLLACRCNFFQRLLG------------PGVPSPVVLSTVPAEAFLAV 81
Cdd:cd18310     4 SSDLENLLDSPDlfYSDAEIIVEGGR-PVPVHRCILAARSPFFRDIFAsakaegantkpkLELRELIPGGIVGYDAFMLV 82

                          90
                  ....*....|.
gi 1850023733  82 LEFLYTNSVKL 92
Cdd:cd18310    83 LSYLYSGRLRL 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2 is also called chromosome condensation 1-like (CHC1-L), RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2. It is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850023733  18 ALRSLINNPQYSDICFVVgqERQEVFAHRCLLACRCNFFQRLLGPGVPSPVVLSTVPAEAFLAVLEFLYTNSVKLHQHSV 97
Cdd:cd18354    10 SLKREFDNPDTADLKFLV--DGKYIYVHKVLLKIRCEHFRSLLNENEEEIIEMSQFSYPVYRAFLEYLYTDSISLSPEDA 87

                          90
                  ....*....|
gi 1850023733  98 LEVLTTAVEY 107
Cdd:cd18354    88 IGLLDLATFY 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850023733  22 LINNPQYSDICFVVGQ--ERQEVFAHRCLLACRCNFFQRLLGPGVPSP---VVLSTVPAEAFLAVLEFLYTNSVKLHQHS 96
Cdd:cd18347    16 LFNNEVLSDVHFLVGKglGSQRIPAHRFVLAVGSAVFDAMFNGGMATTsteIELPDVEPAAFLALLKFLYSDEVQIGPET 95

                          90       100
                  ....*....|....*....|....*...
gi 1850023733  97 VLEVLTTAVEYGLEELRELCLEFVVKVL 124
Cdd:cd18347    96 VMTTLYTAKKYAVPALEAHCVEFLKKNL 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850023733  18 ALRSLINNPQYSDICFVVGQErqEVFAHRCLLACRCNFFQRLL------GPGVPSPVVLSTVPAEAFLAVLEFLYTNSVK 91
Cdd:cd18245     4 ALNSFREEPHLCDATLVVGGE--EIPVQKNVLAAASPYFRAKLnynppkDDGSTYKIELEGISVEVMEEILDYIYTGQIK 81

                          90
                  ....*....|...
gi 1850023733  92 LHQHSVLEVLTTA 104
Cdd:cd18245    82 LSEDNIQDIVQAA 94

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in mammalian neocortex.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850023733 130 CEALQVAVTFGLGSLQERCIAFIEAHSQEALRTRGFLELSATALLPVLRSDKLCVDETELVQAARSWARV 199
Cdd:cd18524     7 CVLLSQSCLFEEPDLTQRCWEVIDAQAELALKSEGFCDIDFQTLESILRRETLNAKEIVVFEAALNWAEV 76

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Structure-specific endonuclease subunit SLX4; SLX4, also called BTB/POZ domain-containing protein 12 (BTBD12), is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases and is required for DNA repair. Mutations of the SLX4 gene are found in Fanconi anemia. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850023733  19 LRSLINNPQYSDICFVVgQERQEVFAHRCLLACRC----------NFFQRLLGPGVPSPVVLSTVPAEAFLAVLEFLYTN 88
Cdd:cd18288     9 FSAMVNNPHLSDVQFQT-DSGEVLYAHSFVLYARCplliqmvhseGFSVEEEGGVTTRRVLLGDVSGEAARCFLQYLYTA 87

                          90       100
                  ....*....|....*....|
gi 1850023733  89 SVKLHQHSVLEVLTTAVEYG 108
Cdd:cd18288    88 DTGLPPGLSPHVSELADRFG 107

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This subfamily includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionarily-conserved role during neuronal development.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1850023733 144 LQERCIAFIEAHSQEALRTRGFLELSATALLPVLRSDKLCVDETELVQAARSWA 197
Cdd:cd18488    21 LMQRCWEVIDAQAELALKSEGFTEIDYKTLESILRRETLNAKESVVFEAALRWA 74

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850023733  20 RSLINNPQYSDICFVVGQerQEVFAHRCLLACRCNFFQRLLGPGVpSPVVLSTVPAEAFLAVLEFLYTNSVKLHQHSV-- 97
Cdd:cd18303    10 ASLFDKELYSDITIKLAD--KSIPAHKFVLAARSEKWSNENLAST-NELDLSDISYEVVLALLRWLYTDELDLTLDDEfl 86

                          90
                  ....*....|....
gi 1850023733  98 LEVLTTAVEYGLEE 111
Cdd:cd18303    87 LELMKAAKRFQLTD 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1850023733  44 AHRCLLACRCNFFQRLL-----GPGVPSPVVLSTVPAEAFLAVLEFLYTNSVKLHQHSVLEVLTTA 104
Cdd:cd18330    32 AHRNILFANSGYFRALLihyiqDSGRHSTASLDIVTSEAFSIILDFLYSGKLDLCSENVIEVMSAA 97

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1850023733 133 LQVAVTFGLGSLQERCIAFIEAHSQEALRTRGFLELSATALLPVLRSDKLCV-DETELVQAARSW 196
Cdd:cd18493     9 LQYAKMCGHKELAEACLEFIAWNFEKVLKSPDWLNLDLDLLVSLLQSSDLVVeDEYTLFQAVEKW 73

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1850023733  30 DICFVVgqERQEVFAHRCLLACRCNFFQRLLGPGV----PSPVVLSTVPAEAFLAVLEFLYTNSVKLHQHSVLEVLTTA 104
Cdd:cd18251    25 DVVLVV--EGKPIEAHRILLAASCDYFRGMFAGGLremqQTEVLIHGVSYNAMCKILDFIYTSELELSLDNVQETLTAA 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850023733  28 YSDICFVVGQERQEVfaHRCLLACRCNFFQRLLGPGVP----SPVVLSTVPAEAFLAVLEFLYTNSVKLHQHSVLEVLTT 103
Cdd:cd18256    20 FCDVQLQVGMELFSV--HRLVLAASSPYFAALFAGGMSesskDVVQIHGVEPDIFHILLDFIYTGVVEVTVSNVQELLVA 97

                  .
gi 1850023733 104 A 104
Cdd:cd18256    98 A 98

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This subfamily includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme in cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1850023733 143 SLQERCIAFIEAHSQEALRTRGFLELSATALLPVLRSDKLCVDETELVQAARSWA 197
Cdd:cd18487    20 QLASLCLETIDKNTAEALAAEGFTDIDLDTLCVVLERDTLGIRECKLFQAVLRWA 74

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1850023733  44 AHRCLLACRCNFFQRLLGPGVPSPVVLSTVPAEAFLAVLEFLYTNSVKLHQHSVLEVLTTA 104
Cdd:cd18208    39 AHRCVLAAGSPFFQDKLLLGYSDIEIPSVVSVQSVQKLIDFMYSGVLRVSQSEALQILTAA 99

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also called lens BTB domain protein, is a BTB-domain-containing Kelch-like protein that is required for proper embryogenesis and plays an essential evolutionarily-conserved role during neuronal development.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1850023733 124 LDVELVCEALQVAVTFGLGSLQERCIAFIEAHSQEALRTRGFLELSATALLPVLRSDKLCVDETELVQAARSWA 197
Cdd:cd18525     1 LEAKNACVLLSQSRLFEEPELTQRCWEVIDAQAELALKSEGFCEIDQQTLEIILTRETLNTKEVVVFEAVLNWA 74

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850023733  38 ERQEVFAHRCLLACRCNFFQRLLGPGVPSP---VVLSTVPAEAFLAVLEFLYTNSVKLHQHSVLEVLTTA 104
Cdd:cd18315     9 EGGSLKAHKLVLAAASPYFAALLKETPPDEhpvIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLA 78

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1850023733  30 DICFVVGQerQEVFAHRCLLACRCNFFQRLL---GPGVPSPVVLSTVPAEAFLAVLEFLYT 87
Cdd:cd18224    28 DVTIVVGN--RSFAAHKAVLACAAGYFQKLFlstELDVARTYVVDFITPANFEKVLSFIYT 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1850023733  30 DICFVVgqERQEVFAHRCLLA-CRCNFFQRLLGPgVPSPVVLS---TVPAEAFLAVLEFLYTNSVKLHQHSVLEVLTTA 104
Cdd:cd18955     3 DVTIVV--EDQRFRAHRAVLAaCSDYFLSRVVGQ-TDGDLVITlpeEVTVKGFEPLLQFAYTAKLLLSKENVLEVCRCA 78

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1850023733  26 PQYSDICFVVGQERqeVFAHRCLLACRCNFFQRLLGPGVPSPVVLS-----TVPA-EAFLAVLEFLYTNSVKL 92
Cdd:cd18309    18 GDFCDITLLLDGHP--IPAHKAILAARCSYFEAMFRSFMPEDNTVNisigeMVPSrQAFDSLLRYIYYGDVTM 88

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.