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Conserved domains on  [gi|1908918806|ref|NP_001374094|]
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NEDD4-binding protein 2-like 2 isoform 18 [Homo sapiens]

Protein Classification

ATP-binding protein( domain architecture ID 1004283)

ATP-binding protein with an AAA (ATPases Associated with various cellular Activities) domain

CATH:  3.40.50.300
Gene Ontology:  GO:0005524|GO:0016887
PubMed:  15037234|18466635|18208389|17897320|16072036|11916378|15037233
SCOP:  2000039

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AAA_33 super family cl38431
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 32-107 4.50e-08

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


The actual alignment was detected with superfamily member pfam13671:

Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 49.23  E-value: 4.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918806  32 TAKQAIDQGRsPVIIDNTNIQAWEMKPYVEVAIGKGYRVEFHEPETwwkfDPEELEKRNK---------HGVSRKKIAQM 102
Cdd:pfam13671  62 LARIALRAGR-PVILDATNLRRDERARLLALAREYGVPVRIVVFEA----PEEVLRERLAararaggdpSDVPEEVLDRQ 136


                  ....*
gi 1908918806 103 LDRYE 107
Cdd:pfam13671 137 KARFE 141
 
Name Accession Description Interval E-value
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 32-107 4.50e-08

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 49.23  E-value: 4.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918806  32 TAKQAIDQGRsPVIIDNTNIQAWEMKPYVEVAIGKGYRVEFHEPETwwkfDPEELEKRNK---------HGVSRKKIAQM 102
Cdd:pfam13671  62 LARIALRAGR-PVILDATNLRRDERARLLALAREYGVPVRIVVFEA----PEEVLRERLAararaggdpSDVPEEVLDRQ 136


                  ....*
gi 1908918806 103 LDRYE 107
Cdd:pfam13671 137 KARFE 141
COG4639 COG4639
Predicted kinase [General function prediction only];
33-107 1.02e-07

Predicted kinase [General function prediction only];


Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 48.29  E-value: 1.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918806  33 AKQAIDQGRsPVIIDNTNIQAWEMKPYVEVAIGKGYRVE---FHEPEtwwkfdpEELEKRNK---HGVSRKKIAQMLDRY 106
Cdd:COG4639    59 ARARLRAGR-LTVVDATNLQREARRRLLALARAYGALVVavvLDVPL-------EVCLARNAardRQVPEEVIRRMLRRL 130


                  .
gi 1908918806 107 E 107
Cdd:COG4639   131 R 131
 
Name Accession Description Interval E-value
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 32-107 4.50e-08

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 49.23  E-value: 4.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918806  32 TAKQAIDQGRsPVIIDNTNIQAWEMKPYVEVAIGKGYRVEFHEPETwwkfDPEELEKRNK---------HGVSRKKIAQM 102
Cdd:pfam13671  62 LARIALRAGR-PVILDATNLRRDERARLLALAREYGVPVRIVVFEA----PEEVLRERLAararaggdpSDVPEEVLDRQ 136


                  ....*
gi 1908918806 103 LDRYE 107
Cdd:pfam13671 137 KARFE 141
COG4639 COG4639
Predicted kinase [General function prediction only];
33-107 1.02e-07

Predicted kinase [General function prediction only];


Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 48.29  E-value: 1.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918806  33 AKQAIDQGRsPVIIDNTNIQAWEMKPYVEVAIGKGYRVE---FHEPEtwwkfdpEELEKRNK---HGVSRKKIAQMLDRY 106
Cdd:COG4639    59 ARARLRAGR-LTVVDATNLQREARRRLLALARAYGALVVavvLDVPL-------EVCLARNAardRQVPEEVIRRMLRRL 130


                  .
gi 1908918806 107 E 107
Cdd:COG4639   131 R 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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