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Conserved domains on  [gi|2069852705|ref|NP_001382489|]
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low-density lipoprotein receptor-related protein 10 precursor [Rattus norvegicus]

Protein Classification

CUB domain-containing protein( domain architecture ID 10207599)

CUB (complement C1r/C1s, Uegf, Bmp1) domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 142-176 2.83e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.45  E-value: 2.83e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2069852705 142 CLQEEFQCLNHRCIPAAQRCDGIDACGDGSDEAGC 176
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 399-433 5.13e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 60.68  E-value: 5.13e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2069852705 399 CQPGNFRCRDEKCVYETWVCDGQPDCTDGSDEWDC 433
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 192-302 7.44e-12

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 62.43  E-value: 7.44e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2069852705 192 CNLTL-EDFYGVFSSPGYSHlaSVSHPQSCLWLLDPHDGRRLAVRFTALDLSYG-----DAVHVYDGagPPETPRLLRSL 265
Cdd:cd00041     1 CGGTLtASTSGTISSPNYPN--NYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSpncsyDYLEIYDG--PSTSSPLLGRF 76

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2069852705 266 THFSNGKavTVETLSGQAVVSYHTVAWSNGRGFNATY 302
Cdd:cd00041    77 CGSTLPP--PIISSGNSLTVRFRSDSSVTGRGFKATY 111
CUB super family cl00049
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 36-136 3.40e-06

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


The actual alignment was detected with superfamily member cd00041:

Pssm-ID: 412131 [Multi-domain]  Cd Length: 113  Bit Score: 46.25  E-value: 3.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2069852705  36 VLLEVQGTLQRPLGRDSRSSPANCTWVILGSKEQTVTVRFQKLHL----ACGSEHLILHSPLQPPVSL-----CEAPAGP 106
Cdd:cd00041     5 LTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLesspNCSYDYLEIYDGPSTSSPLlgrfcGSTLPPP 84

                          90       100       110
                  ....*....|....*....|....*....|
gi 2069852705 107 LQLPGGNVTITYSYAGARApmGQGFLLTYS 136
Cdd:cd00041    85 IISSGNSLTVRFRSDSSVT--GRGFKATYS 112
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 330-353 1.01e-04

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 39.88  E-value: 1.01e-04
                          10        20
                  ....*....|....*....|....
gi 2069852705 330 RCYSEAQRCDGSWDCADGTDEEGC 353
Cdd:cd00112    12 RCIPSSWVCDGEDDCGDGSDEENC 35
 
Name Accession Description Interval E-value
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 142-176 2.83e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.45  E-value: 2.83e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2069852705 142 CLQEEFQCLNHRCIPAAQRCDGIDACGDGSDEAGC 176
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 399-433 5.13e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 60.68  E-value: 5.13e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2069852705 399 CQPGNFRCRDEKCVYETWVCDGQPDCTDGSDEWDC 433
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 192-302 7.44e-12

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 62.43  E-value: 7.44e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2069852705 192 CNLTL-EDFYGVFSSPGYSHlaSVSHPQSCLWLLDPHDGRRLAVRFTALDLSYG-----DAVHVYDGagPPETPRLLRSL 265
Cdd:cd00041     1 CGGTLtASTSGTISSPNYPN--NYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSpncsyDYLEIYDG--PSTSSPLLGRF 76

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2069852705 266 THFSNGKavTVETLSGQAVVSYHTVAWSNGRGFNATY 302
Cdd:cd00041    77 CGSTLPP--PIISSGNSLTVRFRSDSSVTGRGFKATY 111
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 142-173 1.61e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.10  E-value: 1.61e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2069852705  142 CLQEEFQCLNHRCIPAAQRCDGIDACGDGSDE 173
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 399-430 2.83e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.72  E-value: 2.83e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2069852705  399 CQPGNFRCRDEKCVYETWVCDGQPDCTDGSDE 430
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
399-433 7.49e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 54.56  E-value: 7.49e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2069852705 399 CQPGNFRCRDEKCVYETWVCDGQPDCTDGSDEWDC 433
Cdd:pfam00057   3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
142-176 2.59e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 49.94  E-value: 2.59e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2069852705 142 CLQEEFQCLNHRCIPAAQRCDGIDACGDGSDEAGC 176
Cdd:pfam00057   3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 201-302 2.15e-07

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 49.70  E-value: 2.15e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2069852705  201 GVFSSPGYShlASVSHPQSCLWLLDPHDGRRLAVRFTALDLSYG-----DAVHVYDGAGppetpRLLRSLTHF--SNGKA 273
Cdd:smart00042   1 GTITSPNYP--QSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSdnceyDYVEIYDGPS-----ASSPLLGRFcgSEAPP 73

                           90       100
                   ....*....|....*....|....*....
gi 2069852705  274 VTVETLSGQAVVSYHTVAWSNGRGFNATY 302
Cdd:smart00042  74 PVISSSSNSLTLTFVSDSSVQKRGFSARY 102
CUB pfam00431
CUB domain;
192-302 1.24e-06

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 47.67  E-value: 1.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2069852705 192 CNLTLEDFYGVFSSPGYSHlasvSHPQS--CLWLLDPHDGRRLAVRFTALDLS-----YGDAVHVYDGagPPETPRLLRS 264
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPN----PYPPNkdCVWLIRAPPGFRVKLTFQDFELEdhdecGYDYVEIRDG--PSASSPLLGR 74

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2069852705 265 LTHFsnGKAVTVETLSGQAVVSYHTVAWSNGRGFNATY 302
Cdd:pfam00431  75 FCGS--GIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 36-136 3.40e-06

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 46.25  E-value: 3.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2069852705  36 VLLEVQGTLQRPLGRDSRSSPANCTWVILGSKEQTVTVRFQKLHL----ACGSEHLILHSPLQPPVSL-----CEAPAGP 106
Cdd:cd00041     5 LTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLesspNCSYDYLEIYDGPSTSSPLlgrfcGSTLPPP 84

                          90       100       110
                  ....*....|....*....|....*....|
gi 2069852705 107 LQLPGGNVTITYSYAGARApmGQGFLLTYS 136
Cdd:cd00041    85 IISSGNSLTVRFRSDSSVT--GRGFKATYS 112
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 330-353 1.01e-04

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 39.88  E-value: 1.01e-04
                          10        20
                  ....*....|....*....|....
gi 2069852705 330 RCYSEAQRCDGSWDCADGTDEEGC 353
Cdd:cd00112    12 RCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 330-350 1.74e-03

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 36.46  E-value: 1.74e-03
                           10        20
                   ....*....|....*....|.
gi 2069852705  330 RCYSEAQRCDGSWDCADGTDE 350
Cdd:smart00192  13 RCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
330-353 9.78e-03

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 34.53  E-value: 9.78e-03
                          10        20
                  ....*....|....*....|....
gi 2069852705 330 RCYSEAQRCDGSWDCADGTDEEGC 353
Cdd:pfam00057  14 ECIPRSWVCDGDPDCGDGSDEENC 37
 
Name Accession Description Interval E-value
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 142-176 2.83e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.45  E-value: 2.83e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2069852705 142 CLQEEFQCLNHRCIPAAQRCDGIDACGDGSDEAGC 176
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 399-433 5.13e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 60.68  E-value: 5.13e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2069852705 399 CQPGNFRCRDEKCVYETWVCDGQPDCTDGSDEWDC 433
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 192-302 7.44e-12

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 62.43  E-value: 7.44e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2069852705 192 CNLTL-EDFYGVFSSPGYSHlaSVSHPQSCLWLLDPHDGRRLAVRFTALDLSYG-----DAVHVYDGagPPETPRLLRSL 265
Cdd:cd00041     1 CGGTLtASTSGTISSPNYPN--NYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSpncsyDYLEIYDG--PSTSSPLLGRF 76

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2069852705 266 THFSNGKavTVETLSGQAVVSYHTVAWSNGRGFNATY 302
Cdd:cd00041    77 CGSTLPP--PIISSGNSLTVRFRSDSSVTGRGFKATY 111
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 142-173 1.61e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.10  E-value: 1.61e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2069852705  142 CLQEEFQCLNHRCIPAAQRCDGIDACGDGSDE 173
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 399-430 2.83e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.72  E-value: 2.83e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2069852705  399 CQPGNFRCRDEKCVYETWVCDGQPDCTDGSDE 430
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
399-433 7.49e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 54.56  E-value: 7.49e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2069852705 399 CQPGNFRCRDEKCVYETWVCDGQPDCTDGSDEWDC 433
Cdd:pfam00057   3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
142-176 2.59e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 49.94  E-value: 2.59e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2069852705 142 CLQEEFQCLNHRCIPAAQRCDGIDACGDGSDEAGC 176
Cdd:pfam00057   3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 201-302 2.15e-07

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 49.70  E-value: 2.15e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2069852705  201 GVFSSPGYShlASVSHPQSCLWLLDPHDGRRLAVRFTALDLSYG-----DAVHVYDGAGppetpRLLRSLTHF--SNGKA 273
Cdd:smart00042   1 GTITSPNYP--QSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSdnceyDYVEIYDGPS-----ASSPLLGRFcgSEAPP 73

                           90       100
                   ....*....|....*....|....*....
gi 2069852705  274 VTVETLSGQAVVSYHTVAWSNGRGFNATY 302
Cdd:smart00042  74 PVISSSSNSLTLTFVSDSSVQKRGFSARY 102
CUB pfam00431
CUB domain;
192-302 1.24e-06

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 47.67  E-value: 1.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2069852705 192 CNLTLEDFYGVFSSPGYSHlasvSHPQS--CLWLLDPHDGRRLAVRFTALDLS-----YGDAVHVYDGagPPETPRLLRS 264
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPN----PYPPNkdCVWLIRAPPGFRVKLTFQDFELEdhdecGYDYVEIRDG--PSASSPLLGR 74

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2069852705 265 LTHFsnGKAVTVETLSGQAVVSYHTVAWSNGRGFNATY 302
Cdd:pfam00431  75 FCGS--GIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 36-136 3.40e-06

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 46.25  E-value: 3.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2069852705  36 VLLEVQGTLQRPLGRDSRSSPANCTWVILGSKEQTVTVRFQKLHL----ACGSEHLILHSPLQPPVSL-----CEAPAGP 106
Cdd:cd00041     5 LTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLesspNCSYDYLEIYDGPSTSSPLlgrfcGSTLPPP 84

                          90       100       110
                  ....*....|....*....|....*....|
gi 2069852705 107 LQLPGGNVTITYSYAGARApmGQGFLLTYS 136
Cdd:cd00041    85 IISSGNSLTVRFRSDSSVT--GRGFKATYS 112
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 330-353 1.01e-04

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 39.88  E-value: 1.01e-04
                          10        20
                  ....*....|....*....|....
gi 2069852705 330 RCYSEAQRCDGSWDCADGTDEEGC 353
Cdd:cd00112    12 RCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 330-350 1.74e-03

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 36.46  E-value: 1.74e-03
                           10        20
                   ....*....|....*....|.
gi 2069852705  330 RCYSEAQRCDGSWDCADGTDE 350
Cdd:smart00192  13 RCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
330-353 9.78e-03

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 34.53  E-value: 9.78e-03
                          10        20
                  ....*....|....*....|....
gi 2069852705 330 RCYSEAQRCDGSWDCADGTDEEGC 353
Cdd:pfam00057  14 ECIPRSWVCDGDPDCGDGSDEENC 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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