methyl-CpG-binding domain protein 4 isoform 3 [Mus musculus]
List of domain hits
Name | Accession | Description | Interval | E-value | ||
MBD | smart00391 | Methyl-CpG binding domain; Methyl-CpG binding domain, also known as the TAM (TTF-IIP5, ARBP, ... |
66-132 | 2.37e-26 | ||
Methyl-CpG binding domain; Methyl-CpG binding domain, also known as the TAM (TTF-IIP5, ARBP, MeCP1) domain : Pssm-ID: 128673 Cd Length: 77 Bit Score: 102.06 E-value: 2.37e-26
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Nth super family | cl43050 | Endonuclease III [Replication, recombination and repair]; |
399-469 | 3.58e-08 | ||
Endonuclease III [Replication, recombination and repair]; The actual alignment was detected with superfamily member COG0177: Pssm-ID: 439947 [Multi-domain] Cd Length: 198 Bit Score: 53.56 E-value: 3.58e-08
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Name | Accession | Description | Interval | E-value | |||
MBD | smart00391 | Methyl-CpG binding domain; Methyl-CpG binding domain, also known as the TAM (TTF-IIP5, ARBP, ... |
66-132 | 2.37e-26 | |||
Methyl-CpG binding domain; Methyl-CpG binding domain, also known as the TAM (TTF-IIP5, ARBP, MeCP1) domain Pssm-ID: 128673 Cd Length: 77 Bit Score: 102.06 E-value: 2.37e-26
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MeCP2_MBD | cd01396 | MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the ... |
72-144 | 8.81e-25 | |||
MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding protein which binds specifically to methylated DNA. The MBD can recognize a single symmetrically methylated CpG either as naked DNA or within chromatin. MeCP2, MBD1 and MBD2 (and likely MBD3) form complexes with histone deacetylase and are involved in histone deacetylase-dependent repression of transcription. MBD4 is an endonuclease that forms a complex with the DNA mismatch-repair protein MLH1. Pssm-ID: 238690 Cd Length: 77 Bit Score: 97.44 E-value: 8.81e-25
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MBD | pfam01429 | Methyl-CpG binding domain; The Methyl-CpG binding domain (MBD) binds to DNA that contains one ... |
64-135 | 4.29e-23 | |||
Methyl-CpG binding domain; The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase. Pssm-ID: 396147 [Multi-domain] Cd Length: 76 Bit Score: 92.81 E-value: 4.29e-23
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Nth | COG0177 | Endonuclease III [Replication, recombination and repair]; |
399-469 | 3.58e-08 | |||
Endonuclease III [Replication, recombination and repair]; Pssm-ID: 439947 [Multi-domain] Cd Length: 198 Bit Score: 53.56 E-value: 3.58e-08
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ENDO3c | cd00056 | endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ... |
406-489 | 3.95e-04 | |||
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases Pssm-ID: 238013 [Multi-domain] Cd Length: 158 Bit Score: 41.07 E-value: 3.95e-04
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HhH-GPD | pfam00730 | HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of ... |
410-523 | 4.15e-04 | |||
HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of structurally related DNA repair proteins. The superfamily is called the HhH-GPD family after its hallmark Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate. This includes endonuclease III, EC:4.2.99.18 and MutY an A/G-specific adenine glycosylase, both have a C terminal 4Fe-4S cluster. The family also includes 8-oxoguanine DNA glycosylases. The methyl-CPG binding protein MBD4 also contains a related domain that is a thymine DNA glycosylase. The family also includes DNA-3-methyladenine glycosylase II EC:3.2.2.21 and other members of the AlkA family. Pssm-ID: 425841 [Multi-domain] Cd Length: 141 Bit Score: 40.73 E-value: 4.15e-04
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Name | Accession | Description | Interval | E-value | |||
MBD | smart00391 | Methyl-CpG binding domain; Methyl-CpG binding domain, also known as the TAM (TTF-IIP5, ARBP, ... |
66-132 | 2.37e-26 | |||
Methyl-CpG binding domain; Methyl-CpG binding domain, also known as the TAM (TTF-IIP5, ARBP, MeCP1) domain Pssm-ID: 128673 Cd Length: 77 Bit Score: 102.06 E-value: 2.37e-26
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MeCP2_MBD | cd01396 | MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the ... |
72-144 | 8.81e-25 | |||
MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding protein which binds specifically to methylated DNA. The MBD can recognize a single symmetrically methylated CpG either as naked DNA or within chromatin. MeCP2, MBD1 and MBD2 (and likely MBD3) form complexes with histone deacetylase and are involved in histone deacetylase-dependent repression of transcription. MBD4 is an endonuclease that forms a complex with the DNA mismatch-repair protein MLH1. Pssm-ID: 238690 Cd Length: 77 Bit Score: 97.44 E-value: 8.81e-25
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MBD | pfam01429 | Methyl-CpG binding domain; The Methyl-CpG binding domain (MBD) binds to DNA that contains one ... |
64-135 | 4.29e-23 | |||
Methyl-CpG binding domain; The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase. Pssm-ID: 396147 [Multi-domain] Cd Length: 76 Bit Score: 92.81 E-value: 4.29e-23
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MBD | cd00122 | MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of ... |
68-130 | 4.60e-23 | |||
MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding protein which binds specifically to methylated DNA. The MBD can recognize a single symmetrically methylated CpG either as naked DNA or within chromatin. MeCP2, MBD1 and MBD2 (and likely MBD3) form complexes with histone deacetylase and are involved in histone deacetylase-dependent repression of transcription. MBD4 is an endonuclease that forms a complex with the DNA mismatch-repair protein MLH1. The MBDs present in putative chromatin remodelling subunit, BAZ2A, and putative histone methyltransferase, CLLD8, represent two phylogenetically distinct groups within the MBD protein family. Pssm-ID: 238069 Cd Length: 62 Bit Score: 92.39 E-value: 4.60e-23
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Nth | COG0177 | Endonuclease III [Replication, recombination and repair]; |
399-469 | 3.58e-08 | |||
Endonuclease III [Replication, recombination and repair]; Pssm-ID: 439947 [Multi-domain] Cd Length: 198 Bit Score: 53.56 E-value: 3.58e-08
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ENDO3c | cd00056 | endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ... |
406-489 | 3.95e-04 | |||
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases Pssm-ID: 238013 [Multi-domain] Cd Length: 158 Bit Score: 41.07 E-value: 3.95e-04
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HhH-GPD | pfam00730 | HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of ... |
410-523 | 4.15e-04 | |||
HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of structurally related DNA repair proteins. The superfamily is called the HhH-GPD family after its hallmark Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate. This includes endonuclease III, EC:4.2.99.18 and MutY an A/G-specific adenine glycosylase, both have a C terminal 4Fe-4S cluster. The family also includes 8-oxoguanine DNA glycosylases. The methyl-CPG binding protein MBD4 also contains a related domain that is a thymine DNA glycosylase. The family also includes DNA-3-methyladenine glycosylase II EC:3.2.2.21 and other members of the AlkA family. Pssm-ID: 425841 [Multi-domain] Cd Length: 141 Bit Score: 40.73 E-value: 4.15e-04
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HAT_MBD | cd01397 | Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as ... |
72-130 | 4.92e-04 | |||
Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The Drosophila melanogaster toutatis protein, a putative subunit of the chromatin-remodeling complex, and other such proteins in this group share a similar domain architecture with BAZ2A, as does the Caenorhabditis elegans flectin homolog. Pssm-ID: 238691 [Multi-domain] Cd Length: 73 Bit Score: 38.92 E-value: 4.92e-04
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HMT_MBD | cd01395 | Methyl-CpG binding domains (MBD) present in putative histone methyltransferases (HMT) such as ... |
70-130 | 3.05e-03 | |||
Methyl-CpG binding domains (MBD) present in putative histone methyltransferases (HMT) such as CLLD8 and SETDB1 proteins; CLLD8 contains a MBD, a PreSET and a bifurcated SET domain, suggesting that CLLD8 might be associated with methylation-mediated transcriptional repression. SETDB1 and other proteins in this group have a similar domain architecture. SETDB1 is a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins. Pssm-ID: 238689 Cd Length: 60 Bit Score: 36.20 E-value: 3.05e-03
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Blast search parameters | ||||
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