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Conserved domains on  [gi|2318801119|ref|NP_001399690|]
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acid-sensing ion channel 1 isoform g [Homo sapiens]

Protein Classification

amiloride-sensitive sodium channel family protein( domain architecture ID 235)

amiloride-sensitive sodium channel family protein such as vertebrate acid-sensing ion channels which are cation channels with high affinity for sodium; may be partial

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ENaC super family cl47122
sodium channel transporter; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC ...
1-301 4.48e-147

sodium channel transporter; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC family consists of sodium channels from animals and has no recognizable homologues in other eukaryotes or bacteria. The vertebrate ENaC proteins from epithelial cells cluster tightly together on the phylogenetic tree: voltage-insensitive ENaC homologues are also found in the brain. Eleven sequenced C. elegans proteins, including the degenerins, are distantly related to the vertebrate proteins as well as to each other. At least some ofthese proteins form part of a mechano-transducing complex for touch sensitivity. Other members of the ENaC family, the acid-sensing ion channels, ASIC1-3,are homo- or hetero-oligomeric neuronal H+-gated channels that mediate pain sensation in response to tissue acidosis. The homologous Helix aspersa(FMRF-amide)-activated Na+ channel is the first peptide neurotransmitter-gated ionotropic receptor to be sequenced.Mammalian ENaC is important for the maintenance of Na+ balance and the regulation of blood pressure. Three homologous ENaC subunits, a, b and g, havebeen shown to assemble to form the highly Na+-selective channel.This model is designed from the vertebrate members of the ENaC family. [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR00859:

Pssm-ID: 273304 [Multi-domain]  Cd Length: 595  Bit Score: 426.45  E-value: 4.48e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318801119   1 MKGGTGNGLEIMLDIQQDEYLPVWGEtdetsfEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGT 80
Cdd:TIGR00859 267 SMPGAENGLKLVLDIEQDEYLPLLST------EAGARVMVHSQDEPPFIDDLGFGVRPGTETSISMQEDELQRLGGPYGD 340
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318801119  81 CkavTMD-SDLDFFD----SYSITACRIDCETRYLVENCNCRMVHMP--GDAPYCTPEQYKECADPALDFLVEKDQE--- 150
Cdd:TIGR00859 341 C---TENgSDVPVENlynsSYSIQACLRSCFQRYMVENCGCAYYHYPlpGGAEYCNYEQHPDWAYCYYKLYAEFDQEelg 417
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318801119 151 -YCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSE----QYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGD 225
Cdd:TIGR00859 418 cFSVCREPCNFTEYKLTLSMARWPSAASEDWLLHVLSRQNeyniTLIRNGIAKLNIFFEELNYRTIEESPAYNVVTLLSN 497
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318801119 226 IGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKC-QKEAKR------------SSADKGVALSLDDVKR-------- 284
Cdd:TIGR00859 498 LGGQMGLWMGASVLCVLELLELIIDLIFITLLRLLWRfRKWWQRrrgppyaeppepVSADTPPSLQLDDPPTfpsalplp 577
                         330
                  ....*....|....*..
gi 2318801119 285 HNPCESLRGHPAGMTYA 301
Cdd:TIGR00859 578 HASGLSLPGTPPPNYNT 594
 
Name Accession Description Interval E-value
ENaC TIGR00859
sodium channel transporter; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC ...
1-301 4.48e-147

sodium channel transporter; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC family consists of sodium channels from animals and has no recognizable homologues in other eukaryotes or bacteria. The vertebrate ENaC proteins from epithelial cells cluster tightly together on the phylogenetic tree: voltage-insensitive ENaC homologues are also found in the brain. Eleven sequenced C. elegans proteins, including the degenerins, are distantly related to the vertebrate proteins as well as to each other. At least some ofthese proteins form part of a mechano-transducing complex for touch sensitivity. Other members of the ENaC family, the acid-sensing ion channels, ASIC1-3,are homo- or hetero-oligomeric neuronal H+-gated channels that mediate pain sensation in response to tissue acidosis. The homologous Helix aspersa(FMRF-amide)-activated Na+ channel is the first peptide neurotransmitter-gated ionotropic receptor to be sequenced.Mammalian ENaC is important for the maintenance of Na+ balance and the regulation of blood pressure. Three homologous ENaC subunits, a, b and g, havebeen shown to assemble to form the highly Na+-selective channel.This model is designed from the vertebrate members of the ENaC family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273304 [Multi-domain]  Cd Length: 595  Bit Score: 426.45  E-value: 4.48e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318801119   1 MKGGTGNGLEIMLDIQQDEYLPVWGEtdetsfEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGT 80
Cdd:TIGR00859 267 SMPGAENGLKLVLDIEQDEYLPLLST------EAGARVMVHSQDEPPFIDDLGFGVRPGTETSISMQEDELQRLGGPYGD 340
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318801119  81 CkavTMD-SDLDFFD----SYSITACRIDCETRYLVENCNCRMVHMP--GDAPYCTPEQYKECADPALDFLVEKDQE--- 150
Cdd:TIGR00859 341 C---TENgSDVPVENlynsSYSIQACLRSCFQRYMVENCGCAYYHYPlpGGAEYCNYEQHPDWAYCYYKLYAEFDQEelg 417
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318801119 151 -YCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSE----QYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGD 225
Cdd:TIGR00859 418 cFSVCREPCNFTEYKLTLSMARWPSAASEDWLLHVLSRQNeyniTLIRNGIAKLNIFFEELNYRTIEESPAYNVVTLLSN 497
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318801119 226 IGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKC-QKEAKR------------SSADKGVALSLDDVKR-------- 284
Cdd:TIGR00859 498 LGGQMGLWMGASVLCVLELLELIIDLIFITLLRLLWRfRKWWQRrrgppyaeppepVSADTPPSLQLDDPPTfpsalplp 577
                         330
                  ....*....|....*..
gi 2318801119 285 HNPCESLRGHPAGMTYA 301
Cdd:TIGR00859 578 HASGLSLPGTPPPNYNT 594
ASC pfam00858
Amiloride-sensitive sodium channel;
1-247 1.50e-82

Amiloride-sensitive sodium channel;


Pssm-ID: 459966 [Multi-domain]  Cd Length: 439  Bit Score: 256.33  E-value: 1.50e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318801119   1 MKGGTGNGLEIMLDIQQDEYlpvwgETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGT 80
Cdd:pfam00858 195 KGAGSGRGLSLILNIQQSET-----YSPLDYQAAGFKVSIHSPGEPPDVDKRGFSVPPGTETSVGIQPTEITTLKRPYGN 269
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318801119  81 CkaVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKeCADPALDFLVE-KDQEYCV-CEMPC 158
Cdd:pfam00858 270 C--TFDDEKLLYFKSYSQSNCLLECRQNYILKLCGCVPFFYPLPPGTKTGADIP-CLLNYEDHLLEvNEGLSCQdCLPPC 346
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318801119 159 NLTRYGKELSMVKIPSKASAKYLAKKFNK----SEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFI 234
Cdd:pfam00858 347 NETEYETEISYSTWPSLSSQLFLLYYELStynnSSSTIRENLAKLNIYFKELNYETYRRSPAYTWTDLLSSIGGQLGLFL 426
                         250
                  ....*....|...
gi 2318801119 235 GASILTVLELFDY 247
Cdd:pfam00858 427 GASVLSLVEIVYF 439
 
Name Accession Description Interval E-value
ENaC TIGR00859
sodium channel transporter; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC ...
1-301 4.48e-147

sodium channel transporter; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC family consists of sodium channels from animals and has no recognizable homologues in other eukaryotes or bacteria. The vertebrate ENaC proteins from epithelial cells cluster tightly together on the phylogenetic tree: voltage-insensitive ENaC homologues are also found in the brain. Eleven sequenced C. elegans proteins, including the degenerins, are distantly related to the vertebrate proteins as well as to each other. At least some ofthese proteins form part of a mechano-transducing complex for touch sensitivity. Other members of the ENaC family, the acid-sensing ion channels, ASIC1-3,are homo- or hetero-oligomeric neuronal H+-gated channels that mediate pain sensation in response to tissue acidosis. The homologous Helix aspersa(FMRF-amide)-activated Na+ channel is the first peptide neurotransmitter-gated ionotropic receptor to be sequenced.Mammalian ENaC is important for the maintenance of Na+ balance and the regulation of blood pressure. Three homologous ENaC subunits, a, b and g, havebeen shown to assemble to form the highly Na+-selective channel.This model is designed from the vertebrate members of the ENaC family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273304 [Multi-domain]  Cd Length: 595  Bit Score: 426.45  E-value: 4.48e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318801119   1 MKGGTGNGLEIMLDIQQDEYLPVWGEtdetsfEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGT 80
Cdd:TIGR00859 267 SMPGAENGLKLVLDIEQDEYLPLLST------EAGARVMVHSQDEPPFIDDLGFGVRPGTETSISMQEDELQRLGGPYGD 340
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318801119  81 CkavTMD-SDLDFFD----SYSITACRIDCETRYLVENCNCRMVHMP--GDAPYCTPEQYKECADPALDFLVEKDQE--- 150
Cdd:TIGR00859 341 C---TENgSDVPVENlynsSYSIQACLRSCFQRYMVENCGCAYYHYPlpGGAEYCNYEQHPDWAYCYYKLYAEFDQEelg 417
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318801119 151 -YCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSE----QYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGD 225
Cdd:TIGR00859 418 cFSVCREPCNFTEYKLTLSMARWPSAASEDWLLHVLSRQNeyniTLIRNGIAKLNIFFEELNYRTIEESPAYNVVTLLSN 497
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318801119 226 IGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKC-QKEAKR------------SSADKGVALSLDDVKR-------- 284
Cdd:TIGR00859 498 LGGQMGLWMGASVLCVLELLELIIDLIFITLLRLLWRfRKWWQRrrgppyaeppepVSADTPPSLQLDDPPTfpsalplp 577
                         330
                  ....*....|....*..
gi 2318801119 285 HNPCESLRGHPAGMTYA 301
Cdd:TIGR00859 578 HASGLSLPGTPPPNYNT 594
ASC pfam00858
Amiloride-sensitive sodium channel;
1-247 1.50e-82

Amiloride-sensitive sodium channel;


Pssm-ID: 459966 [Multi-domain]  Cd Length: 439  Bit Score: 256.33  E-value: 1.50e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318801119   1 MKGGTGNGLEIMLDIQQDEYlpvwgETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGT 80
Cdd:pfam00858 195 KGAGSGRGLSLILNIQQSET-----YSPLDYQAAGFKVSIHSPGEPPDVDKRGFSVPPGTETSVGIQPTEITTLKRPYGN 269
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318801119  81 CkaVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKeCADPALDFLVE-KDQEYCV-CEMPC 158
Cdd:pfam00858 270 C--TFDDEKLLYFKSYSQSNCLLECRQNYILKLCGCVPFFYPLPPGTKTGADIP-CLLNYEDHLLEvNEGLSCQdCLPPC 346
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318801119 159 NLTRYGKELSMVKIPSKASAKYLAKKFNK----SEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFI 234
Cdd:pfam00858 347 NETEYETEISYSTWPSLSSQLFLLYYELStynnSSSTIRENLAKLNIYFKELNYETYRRSPAYTWTDLLSSIGGQLGLFL 426
                         250
                  ....*....|...
gi 2318801119 235 GASILTVLELFDY 247
Cdd:pfam00858 427 GASVLSLVEIVYF 439
deg-1 TIGR00867
degenerin; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC family consists of ...
8-243 1.75e-33

degenerin; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC family consists of sodium channels from animals and has no recognizable homologues in other eukaryotes or bacteria. The vertebrate ENaC proteins from epithelial cells cluster tightly together on the phylogenetic tree: voltage-insensitive ENaC homologues are also found in the brain. Eleven sequenced C. elegans proteins, including the degenerins, are distantly related to the vertebrate proteins as well as to each other. At least some ofthese proteins form part of a mechano-transducing complex for touch sensitivity. Other members of the ENaC family, the acid-sensing ion channels, ASIC1-3,are homo- or hetero-oligomeric neuronal H+-gated channels that mediate pain sensation in response to tissue acidosis. The homologous Helix aspersa(FMRF-amide)-activated Na+ channel is the first peptide neurotransmitter-gated ionotropic receptor to be sequenced.Mammalian ENaC is important for the maintenance of Na+ balance and the regulation of blood pressure. Three homologous ENaC subunits, a, b and g, havebeen shown to assemble to form the highly Na+-selective channel.This model is designed from the invertebrate members of the ENaC family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273309 [Multi-domain]  Cd Length: 600  Bit Score: 129.58  E-value: 1.75e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318801119   8 GLEIMLDIQQDEYLPvwgetdeTSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMD 87
Cdd:TIGR00867 357 GLRLLLFVNQSDYLP-------TTEAAGVRLTIHDKDEFPFPDTFGYSAPTGYISSFGVRLKQMSRLPAPYGNCVDTGKD 429
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318801119  88 SDLDFFD-SYSITACRIDCETRYLVENCNCrmvhmpGDAPYCTPEQYKECADP---ALDFL---------VEKDQEYCVC 154
Cdd:TIGR00867 430 SSYIYKGyIYSPEGCHRSCFQRLIIAKCGC------ADPRFPVPEGTRHCQAFnktDRECLetltgdlgeLHHSIFKCRC 503
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2318801119 155 EMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSE----QYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQM 230
Cdd:TIGR00867 504 QQPCQESIYTTTYSAAKWPSGSLKITLGSCDSNTAsecnEYYRENAAMIEVFYEQLNYELLTESEAYTLVNLIADFGGQL 583
                         250
                  ....*....|...
gi 2318801119 231 GLFIGASILTVLE 243
Cdd:TIGR00867 584 GLWLGASVITVCE 596
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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