NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|17738302|ref|NP_001841|]
View 

collagen alpha-1(VIII) chain precursor [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
C1Q smart00110
Complement component C1q domain; Globular domain found in many collagens and eponymously in ...
 609-744 1.39e-66

Complement component C1q domain; Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tumour necrosis factor.


:

Pssm-ID: 128420  Cd Length: 135  Bit Score: 216.01  E-value: 1.39e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17738302    609 GGPAYEMPAFTAELTAPFPPVGAPVKFNKLLYNGRQNYNPQTGIFTCEVPGVYYFAYHVHCKGGNVWVALFKNNEPVMYT 688
Cdd:smart00110   1 NYKAQPRSAFSVIRSNRPPPPGQPIRFDKVLYNQQGHYDPRTGKFTCPVPGVYYFSYHVESKGRNVKVSLMKNGIQVMST 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 17738302    689 YDEYKKGFLDQASGSAVLLLRPGDRVFLQMPSEQaAGLYAGQYVHSSFSGYLLYPM 744
Cdd:smart00110  81 YDEYQKGLYDVASGGALLQLRQGDQVWLELPDEK-NGLYAGEYVDSTFSGFLLFPD 135
gly_rich_SclB super family cl45768
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 225-492 2.11e-16

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


The actual alignment was detected with superfamily member NF038329:

Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 82.26  E-value: 2.11e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17738302  225 RGPKGLPGPQGLRGPKGDKGFGMPGAPgvkgppgmhgppgpvgLPGVGKPGVTGFPGPQGPLGKPGAPGEPGPQGPIGVP 304
Cdd:NF038329 128 AGPAGEQGPRGDRGETGPAGPAGPPGP----------------QGERGEKGPAGPQGEAGPQGPAGKDGEAGAKGPAGEK 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17738302  305 GVQGPPGIPG-IGKPGQDGIPGQPGFPGGKGEQGLPGLPGPPGLPGIGKPGFPGPKGDRGMGGVPGALGPRGEKGPIGAp 383
Cdd:NF038329 192 GPQGPRGETGpAGEQGPAGPAGPDGEAGPAGEDGPAGPAGDGQQGPDGDPGPTGEDGPQGPDGPAGKDGPRGDRGEAGP- 270

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17738302  384 giggppgepglpgipgpmgppgaigfPGPKGEggivgpqgppgpkgepglQGFPGKPGFLGEVGPPGMRGLPGPIGPKGE 463
Cdd:NF038329 271 --------------------------DGPDGK------------------DGERGPVGPAGKDGQNGKDGLPGKDGKDGQ 306

                        250       260
                 ....*....|....*....|....*....
gi 17738302  464 AGQKGVPGLPGVPGLLGPKGEPGIPGDQG 492
Cdd:NF038329 307 NGKDGLPGKDGKDGQPGKDGLPGKDGKDG 335
 
Name Accession Description Interval E-value
C1Q smart00110
Complement component C1q domain; Globular domain found in many collagens and eponymously in ...
 609-744 1.39e-66

Complement component C1q domain; Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tumour necrosis factor.


Pssm-ID: 128420  Cd Length: 135  Bit Score: 216.01  E-value: 1.39e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17738302    609 GGPAYEMPAFTAELTAPFPPVGAPVKFNKLLYNGRQNYNPQTGIFTCEVPGVYYFAYHVHCKGGNVWVALFKNNEPVMYT 688
Cdd:smart00110   1 NYKAQPRSAFSVIRSNRPPPPGQPIRFDKVLYNQQGHYDPRTGKFTCPVPGVYYFSYHVESKGRNVKVSLMKNGIQVMST 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 17738302    689 YDEYKKGFLDQASGSAVLLLRPGDRVFLQMPSEQaAGLYAGQYVHSSFSGYLLYPM 744
Cdd:smart00110  81 YDEYQKGLYDVASGGALLQLRQGDQVWLELPDEK-NGLYAGEYVDSTFSGFLLFPD 135
C1q pfam00386
C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement ...
 617-741 1.01e-51

C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement system.


Pssm-ID: 395310 [Multi-domain]  Cd Length: 126  Bit Score: 175.55  E-value: 1.01e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17738302   617 AFTAELTAPFP-PVGAPVKFNKLLYNGRQNYNPQTGIFTCEVPGVYYFAYHVH-CKGGNVWVALFKNNEPVMYTYDEYKK 694
Cdd:pfam00386   1 AFSAGRTTGLTaPNEQPVRFDKVLTNIGGHYDPATGKFTCPVPGVYYFSYHITtVDGKSLYVSLVKNGQEVVSFYDQPQK 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 17738302   695 GFLDQASGSAVLLLRPGDRVFLQMPSEQaaGLYAGQY-VHSSFSGYLL 741
Cdd:pfam00386  81 GSLDVASGSVVLELQRGDEVWLQLTGYN--GLYYDGSdTDSTFSGFLL 126
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 225-492 2.11e-16

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 82.26  E-value: 2.11e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17738302  225 RGPKGLPGPQGLRGPKGDKGFGMPGAPgvkgppgmhgppgpvgLPGVGKPGVTGFPGPQGPLGKPGAPGEPGPQGPIGVP 304
Cdd:NF038329 128 AGPAGEQGPRGDRGETGPAGPAGPPGP----------------QGERGEKGPAGPQGEAGPQGPAGKDGEAGAKGPAGEK 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17738302  305 GVQGPPGIPG-IGKPGQDGIPGQPGFPGGKGEQGLPGLPGPPGLPGIGKPGFPGPKGDRGMGGVPGALGPRGEKGPIGAp 383
Cdd:NF038329 192 GPQGPRGETGpAGEQGPAGPAGPDGEAGPAGEDGPAGPAGDGQQGPDGDPGPTGEDGPQGPDGPAGKDGPRGDRGEAGP- 270

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17738302  384 giggppgepglpgipgpmgppgaigfPGPKGEggivgpqgppgpkgepglQGFPGKPGFLGEVGPPGMRGLPGPIGPKGE 463
Cdd:NF038329 271 --------------------------DGPDGK------------------DGERGPVGPAGKDGQNGKDGLPGKDGKDGQ 306

                        250       260
                 ....*....|....*....|....*....
gi 17738302  464 AGQKGVPGLPGVPGLLGPKGEPGIPGDQG 492
Cdd:NF038329 307 NGKDGLPGKDGKDGQPGKDGLPGKDGKDG 335
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 224-476 3.48e-16

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 81.88  E-value: 3.48e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17738302  224 DRGPKGLPGPQGLRGPKGDKGFGMPGAPgvkgppgmhgPPGPVGLPGVGKPGVTGFPGPQGPLGKPGAPGEPGPQGPIGV 303
Cdd:NF038329 121 EPGPAGPAGPAGEQGPRGDRGETGPAGP----------AGPPGPQGERGEKGPAGPQGEAGPQGPAGKDGEAGAKGPAGE 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17738302  304 PGVQGPPGIPG-IGKPGQDGIPGQPGFPGGKGEQGLPGLPGPPGLPGIGKPGFPGPKGDRGMGGVPGALGPRGEKGPIGA 382
Cdd:NF038329 191 KGPQGPRGETGpAGEQGPAGPAGPDGEAGPAGEDGPAGPAGDGQQGPDGDPGPTGEDGPQGPDGPAGKDGPRGDRGEAGP 270

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17738302  383 PGIGGPPGEPGLPGIPGPMGPPGAIGFPGPKGEGGIvgpqgppgpkgepglQGFPGKPGFLGEVGPPGMRGLPGPIGPKG 462
Cdd:NF038329 271 DGPDGKDGERGPVGPAGKDGQNGKDGLPGKDGKDGQ---------------NGKDGLPGKDGKDGQPGKDGLPGKDGKDG 335

                        250
                 ....*....|....
gi 17738302  463 EAGqKGVPGLPGVP 476
Cdd:NF038329 336 QPG-KPAPKTPEVP 348
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 146-375 1.45e-12

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 70.32  E-value: 1.45e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17738302  146 KGKPGPQGYPG----VGKPGMPGMPGKPGAMGMPGAKGEIGQKGEIGPMGIPGPQGPpgphglpgIGKPGGPGLPGQPGP 221
Cdd:NF038329 119 KGEPGPAGPAGpageQGPRGDRGETGPAGPAGPPGPQGERGEKGPAGPQGEAGPQGP--------AGKDGEAGAKGPAGE 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17738302  222 KGDRGPKGLPGPQGLRGPKGDKgfGMPGAPGVKGPPGMHGPPGPVGLPGVGKPGVTGFPGPQGPLGKPGA------PGEP 295
Cdd:NF038329 191 KGPQGPRGETGPAGEQGPAGPA--GPDGEAGPAGEDGPAGPAGDGQQGPDGDPGPTGEDGPQGPDGPAGKdgprgdRGEA 268

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17738302  296 GPQGPIGVPGVQGPPGIPgiGKPGQDGIPGQPGFPGGKGEQGLpglpgppglpgigkpgfPGPKGDRGMGGVPGALGPRG 375
Cdd:NF038329 269 GPDGPDGKDGERGPVGPA--GKDGQNGKDGLPGKDGKDGQNGK-----------------DGLPGKDGKDGQPGKDGLPG 329
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 409-548 2.02e-06

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 51.06  E-value: 2.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17738302  409 FPGPKGEGGIVGPQGPPGPKGEPGLQGFPGKPGFLGEVGPPGMRGLPGPIGPKGEAGQKGVPGLPGVPGLLGPKGEPGIP 488
Cdd:NF038329 115 GDGEKGEPGPAGPAGPAGEQGPRGDRGETGPAGPAGPPGPQGERGEKGPAGPQGEAGPQGPAGKDGEAGAKGPAGEKGPQ 194

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17738302  489 GDQGLQGPPGIPGIGGPSGPIGPPGIPGPKGEPGLPGPPGFPGIGKPGVAGLHGPPGKPG 548
Cdd:NF038329 195 GPRGETGPAGEQGPAGPAGPDGEAGPAGEDGPAGPAGDGQQGPDGDPGPTGEDGPQGPDG 254
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 356-548 8.98e-06

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 48.75  E-value: 8.98e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17738302  356 PGPKGDRGMGGVPGALGPRGEKGPIGAPGIGGPPgepglpgipgpmgppgaigfpGPKGEGGIVGPQGPPGPkgepglQG 435
Cdd:NF038329 122 PGPAGPAGPAGEQGPRGDRGETGPAGPAGPPGPQ---------------------GERGEKGPAGPQGEAGP------QG 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17738302  436 FPGKPGFLGEVGPPGMRGLPGPIGPKGEAGQKGVPGLPGVPGLLGPKGEPGIPGDQGLQGPPGIPGIGGPSGPIGPPGIP 515
Cdd:NF038329 175 PAGKDGEAGAKGPAGEKGPQGPRGETGPAGEQGPAGPAGPDGEAGPAGEDGPAGPAGDGQQGPDGDPGPTGEDGPQGPDG 254

                        170       180       190
                 ....*....|....*....|....*....|...
gi 17738302  516 GPKGEPGLPGPPGFPGIGKPGVAGLHGPPGKPG 548
Cdd:NF038329 255 PAGKDGPRGDRGEAGPDGPDGKDGERGPVGPAG 287
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 146-317 4.50e-04

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 43.36  E-value: 4.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17738302  146 KGKPGPQGYPG----VGKPGMPGMPGKPGAMGMPGAKGEIGQKGEIGPMGIPGPQGPPGPHGLPGIGKPGGPGLPGQPGP 221
Cdd:NF038329 167 QGEAGPQGPAGkdgeAGAKGPAGEKGPQGPRGETGPAGEQGPAGPAGPDGEAGPAGEDGPAGPAGDGQQGPDGDPGPTGE 246

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17738302  222 KGDRGPKGLPGPQGLRGPKGDKGF----------GMPGAPGVKGPPGMHGPPGPVGL----------------PGVGKPG 275
Cdd:NF038329 247 DGPQGPDGPAGKDGPRGDRGEAGPdgpdgkdgerGPVGPAGKDGQNGKDGLPGKDGKdgqngkdglpgkdgkdGQPGKDG 326

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 17738302  276 VTGFPGPQGPLGKPGAPGEPGPQGPIGVPGVQGPPGIPGIGK 317
Cdd:NF038329 327 LPGKDGKDGQPGKPAPKTPEVPQKPDTAPHTPKTPQIPGQSK 368
Collagen pfam01391
Collagen triple helix repeat (20 copies); Members of this family belong to the collagen ...
 287-335 6.06e-04

Collagen triple helix repeat (20 copies); Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxy-proline. Collagens are post translationally modified by proline hydroxylase to form the hydroxy-proline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure. The family includes bacterial collagen-like triple-helix repeat proteins.


Pssm-ID: 460189 [Multi-domain]  Cd Length: 57  Bit Score: 38.24  E-value: 6.06e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 17738302   287 GKPGAPGEPGPQGPIGVPGVQGPPGIPGI-GKPGQDGIPGQPGFPGGKGE 335
Cdd:pfam01391   1 GPPGPPGPPGPPGPPGPPGPPGPPGPPGPpGEPGPPGPPGPPGPPGPPGA 50
 
Name Accession Description Interval E-value
C1Q smart00110
Complement component C1q domain; Globular domain found in many collagens and eponymously in ...
 609-744 1.39e-66

Complement component C1q domain; Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tumour necrosis factor.


Pssm-ID: 128420  Cd Length: 135  Bit Score: 216.01  E-value: 1.39e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17738302    609 GGPAYEMPAFTAELTAPFPPVGAPVKFNKLLYNGRQNYNPQTGIFTCEVPGVYYFAYHVHCKGGNVWVALFKNNEPVMYT 688
Cdd:smart00110   1 NYKAQPRSAFSVIRSNRPPPPGQPIRFDKVLYNQQGHYDPRTGKFTCPVPGVYYFSYHVESKGRNVKVSLMKNGIQVMST 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 17738302    689 YDEYKKGFLDQASGSAVLLLRPGDRVFLQMPSEQaAGLYAGQYVHSSFSGYLLYPM 744
Cdd:smart00110  81 YDEYQKGLYDVASGGALLQLRQGDQVWLELPDEK-NGLYAGEYVDSTFSGFLLFPD 135
C1q pfam00386
C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement ...
 617-741 1.01e-51

C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement system.


Pssm-ID: 395310 [Multi-domain]  Cd Length: 126  Bit Score: 175.55  E-value: 1.01e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17738302   617 AFTAELTAPFP-PVGAPVKFNKLLYNGRQNYNPQTGIFTCEVPGVYYFAYHVH-CKGGNVWVALFKNNEPVMYTYDEYKK 694
Cdd:pfam00386   1 AFSAGRTTGLTaPNEQPVRFDKVLTNIGGHYDPATGKFTCPVPGVYYFSYHITtVDGKSLYVSLVKNGQEVVSFYDQPQK 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 17738302   695 GFLDQASGSAVLLLRPGDRVFLQMPSEQaaGLYAGQY-VHSSFSGYLL 741
Cdd:pfam00386  81 GSLDVASGSVVLELQRGDEVWLQLTGYN--GLYYDGSdTDSTFSGFLL 126
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 225-492 2.11e-16

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 82.26  E-value: 2.11e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17738302  225 RGPKGLPGPQGLRGPKGDKGFGMPGAPgvkgppgmhgppgpvgLPGVGKPGVTGFPGPQGPLGKPGAPGEPGPQGPIGVP 304
Cdd:NF038329 128 AGPAGEQGPRGDRGETGPAGPAGPPGP----------------QGERGEKGPAGPQGEAGPQGPAGKDGEAGAKGPAGEK 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17738302  305 GVQGPPGIPG-IGKPGQDGIPGQPGFPGGKGEQGLPGLPGPPGLPGIGKPGFPGPKGDRGMGGVPGALGPRGEKGPIGAp 383
Cdd:NF038329 192 GPQGPRGETGpAGEQGPAGPAGPDGEAGPAGEDGPAGPAGDGQQGPDGDPGPTGEDGPQGPDGPAGKDGPRGDRGEAGP- 270

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17738302  384 giggppgepglpgipgpmgppgaigfPGPKGEggivgpqgppgpkgepglQGFPGKPGFLGEVGPPGMRGLPGPIGPKGE 463
Cdd:NF038329 271 --------------------------DGPDGK------------------DGERGPVGPAGKDGQNGKDGLPGKDGKDGQ 306

                        250       260
                 ....*....|....*....|....*....
gi 17738302  464 AGQKGVPGLPGVPGLLGPKGEPGIPGDQG 492
Cdd:NF038329 307 NGKDGLPGKDGKDGQPGKDGLPGKDGKDG 335
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 224-476 3.48e-16

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 81.88  E-value: 3.48e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17738302  224 DRGPKGLPGPQGLRGPKGDKGFGMPGAPgvkgppgmhgPPGPVGLPGVGKPGVTGFPGPQGPLGKPGAPGEPGPQGPIGV 303
Cdd:NF038329 121 EPGPAGPAGPAGEQGPRGDRGETGPAGP----------AGPPGPQGERGEKGPAGPQGEAGPQGPAGKDGEAGAKGPAGE 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17738302  304 PGVQGPPGIPG-IGKPGQDGIPGQPGFPGGKGEQGLPGLPGPPGLPGIGKPGFPGPKGDRGMGGVPGALGPRGEKGPIGA 382
Cdd:NF038329 191 KGPQGPRGETGpAGEQGPAGPAGPDGEAGPAGEDGPAGPAGDGQQGPDGDPGPTGEDGPQGPDGPAGKDGPRGDRGEAGP 270

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17738302  383 PGIGGPPGEPGLPGIPGPMGPPGAIGFPGPKGEGGIvgpqgppgpkgepglQGFPGKPGFLGEVGPPGMRGLPGPIGPKG 462
Cdd:NF038329 271 DGPDGKDGERGPVGPAGKDGQNGKDGLPGKDGKDGQ---------------NGKDGLPGKDGKDGQPGKDGLPGKDGKDG 335

                        250
                 ....*....|....
gi 17738302  463 EAGqKGVPGLPGVP 476
Cdd:NF038329 336 QPG-KPAPKTPEVP 348
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 146-375 1.45e-12

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 70.32  E-value: 1.45e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17738302  146 KGKPGPQGYPG----VGKPGMPGMPGKPGAMGMPGAKGEIGQKGEIGPMGIPGPQGPpgphglpgIGKPGGPGLPGQPGP 221
Cdd:NF038329 119 KGEPGPAGPAGpageQGPRGDRGETGPAGPAGPPGPQGERGEKGPAGPQGEAGPQGP--------AGKDGEAGAKGPAGE 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17738302  222 KGDRGPKGLPGPQGLRGPKGDKgfGMPGAPGVKGPPGMHGPPGPVGLPGVGKPGVTGFPGPQGPLGKPGA------PGEP 295
Cdd:NF038329 191 KGPQGPRGETGPAGEQGPAGPA--GPDGEAGPAGEDGPAGPAGDGQQGPDGDPGPTGEDGPQGPDGPAGKdgprgdRGEA 268

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17738302  296 GPQGPIGVPGVQGPPGIPgiGKPGQDGIPGQPGFPGGKGEQGLpglpgppglpgigkpgfPGPKGDRGMGGVPGALGPRG 375
Cdd:NF038329 269 GPDGPDGKDGERGPVGPA--GKDGQNGKDGLPGKDGKDGQNGK-----------------DGLPGKDGKDGQPGKDGLPG 329
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 409-548 2.02e-06

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 51.06  E-value: 2.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17738302  409 FPGPKGEGGIVGPQGPPGPKGEPGLQGFPGKPGFLGEVGPPGMRGLPGPIGPKGEAGQKGVPGLPGVPGLLGPKGEPGIP 488
Cdd:NF038329 115 GDGEKGEPGPAGPAGPAGEQGPRGDRGETGPAGPAGPPGPQGERGEKGPAGPQGEAGPQGPAGKDGEAGAKGPAGEKGPQ 194

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17738302  489 GDQGLQGPPGIPGIGGPSGPIGPPGIPGPKGEPGLPGPPGFPGIGKPGVAGLHGPPGKPG 548
Cdd:NF038329 195 GPRGETGPAGEQGPAGPAGPDGEAGPAGEDGPAGPAGDGQQGPDGDPGPTGEDGPQGPDG 254
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 356-548 8.98e-06

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 48.75  E-value: 8.98e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17738302  356 PGPKGDRGMGGVPGALGPRGEKGPIGAPGIGGPPgepglpgipgpmgppgaigfpGPKGEGGIVGPQGPPGPkgepglQG 435
Cdd:NF038329 122 PGPAGPAGPAGEQGPRGDRGETGPAGPAGPPGPQ---------------------GERGEKGPAGPQGEAGP------QG 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17738302  436 FPGKPGFLGEVGPPGMRGLPGPIGPKGEAGQKGVPGLPGVPGLLGPKGEPGIPGDQGLQGPPGIPGIGGPSGPIGPPGIP 515
Cdd:NF038329 175 PAGKDGEAGAKGPAGEKGPQGPRGETGPAGEQGPAGPAGPDGEAGPAGEDGPAGPAGDGQQGPDGDPGPTGEDGPQGPDG 254

                        170       180       190
                 ....*....|....*....|....*....|...
gi 17738302  516 GPKGEPGLPGPPGFPGIGKPGVAGLHGPPGKPG 548
Cdd:NF038329 255 PAGKDGPRGDRGEAGPDGPDGKDGERGPVGPAG 287
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 146-317 4.50e-04

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 43.36  E-value: 4.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17738302  146 KGKPGPQGYPG----VGKPGMPGMPGKPGAMGMPGAKGEIGQKGEIGPMGIPGPQGPPGPHGLPGIGKPGGPGLPGQPGP 221
Cdd:NF038329 167 QGEAGPQGPAGkdgeAGAKGPAGEKGPQGPRGETGPAGEQGPAGPAGPDGEAGPAGEDGPAGPAGDGQQGPDGDPGPTGE 246

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17738302  222 KGDRGPKGLPGPQGLRGPKGDKGF----------GMPGAPGVKGPPGMHGPPGPVGL----------------PGVGKPG 275
Cdd:NF038329 247 DGPQGPDGPAGKDGPRGDRGEAGPdgpdgkdgerGPVGPAGKDGQNGKDGLPGKDGKdgqngkdglpgkdgkdGQPGKDG 326

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 17738302  276 VTGFPGPQGPLGKPGAPGEPGPQGPIGVPGVQGPPGIPGIGK 317
Cdd:NF038329 327 LPGKDGKDGQPGKPAPKTPEVPQKPDTAPHTPKTPQIPGQSK 368
Collagen pfam01391
Collagen triple helix repeat (20 copies); Members of this family belong to the collagen ...
 287-335 6.06e-04

Collagen triple helix repeat (20 copies); Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxy-proline. Collagens are post translationally modified by proline hydroxylase to form the hydroxy-proline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure. The family includes bacterial collagen-like triple-helix repeat proteins.


Pssm-ID: 460189 [Multi-domain]  Cd Length: 57  Bit Score: 38.24  E-value: 6.06e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 17738302   287 GKPGAPGEPGPQGPIGVPGVQGPPGIPGI-GKPGQDGIPGQPGFPGGKGE 335
Cdd:pfam01391   1 GPPGPPGPPGPPGPPGPPGPPGPPGPPGPpGEPGPPGPPGPPGPPGPPGA 50
Collagen pfam01391
Collagen triple helix repeat (20 copies); Members of this family belong to the collagen ...
 433-481 8.81e-04

Collagen triple helix repeat (20 copies); Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxy-proline. Collagens are post translationally modified by proline hydroxylase to form the hydroxy-proline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure. The family includes bacterial collagen-like triple-helix repeat proteins.


Pssm-ID: 460189 [Multi-domain]  Cd Length: 57  Bit Score: 37.86  E-value: 8.81e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 17738302   433 LQGFPGKPGFLGEVGPPGMRGLPGPIGPKGEAGQKGVPGLPGVPGLLGP 481
Cdd:pfam01391   8 PPGPPGPPGPPGPPGPPGPPGPPGEPGPPGPPGPPGPPGPPGAPGAPGP 56
Collagen pfam01391
Collagen triple helix repeat (20 copies); Members of this family belong to the collagen ...
 447-494 1.29e-03

Collagen triple helix repeat (20 copies); Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxy-proline. Collagens are post translationally modified by proline hydroxylase to form the hydroxy-proline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure. The family includes bacterial collagen-like triple-helix repeat proteins.


Pssm-ID: 460189 [Multi-domain]  Cd Length: 57  Bit Score: 37.47  E-value: 1.29e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 17738302   447 GPPGMRGLPGPIGPKGEAGQKGVPGLPGVPGLLGPKGEPGIPGDQGLQ 494
Cdd:pfam01391   1 GPPGPPGPPGPPGPPGPPGPPGPPGPPGPPGEPGPPGPPGPPGPPGPP 48
Collagen pfam01391
Collagen triple helix repeat (20 copies); Members of this family belong to the collagen ...
 274-315 2.22e-03

Collagen triple helix repeat (20 copies); Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxy-proline. Collagens are post translationally modified by proline hydroxylase to form the hydroxy-proline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure. The family includes bacterial collagen-like triple-helix repeat proteins.


Pssm-ID: 460189 [Multi-domain]  Cd Length: 57  Bit Score: 36.70  E-value: 2.22e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 17738302   274 PGVTGFPGPQGPLGKPGAPGEPGPQGPIGVPGVQGPPGIPGI 315
Cdd:pfam01391  12 PGPPGPPGPPGPPGPPGPPGEPGPPGPPGPPGPPGPPGAPGA 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH