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Conserved domains on  [gi|4505895|ref|NP_002660|]
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pleiotropic regulator 1 isoform 1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 196-490 8.89e-89

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 274.21  E-value: 8.89e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505895  196 LYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDL 275
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505895  276 EYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIR 355
Cdd:cd00200  81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505895  356 LWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQNLSGHNAIINTLTVNSDG-VLVSGADN 433
Cdd:cd00200 161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGtIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGyLLASGSED 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 4505895  434 GTMHLWDWRTGYNFQRVHAavqpgsldSESGIFACAFDQSESRLLTAEADKTIKVYR 490
Cdd:cd00200 241 GTIRVWDLRTGECVQTLSG--------HTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 196-490 8.89e-89

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 274.21  E-value: 8.89e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505895  196 LYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDL 275
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505895  276 EYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIR 355
Cdd:cd00200  81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505895  356 LWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQNLSGHNAIINTLTVNSDG-VLVSGADN 433
Cdd:cd00200 161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGtIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGyLLASGSED 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 4505895  434 GTMHLWDWRTGYNFQRVHAavqpgsldSESGIFACAFDQSESRLLTAEADKTIKVYR 490
Cdd:cd00200 241 GTIRVWDLRTGECVQTLSG--------HTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
195-490 4.44e-69

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 227.10  E-value: 4.44e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505895  195 KLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWD 274
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505895  275 LEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTI 354
Cdd:COG2319 191 LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV 270

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505895  355 RLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQNLSGHNAIINTLTVNSDG-VLVSGAD 432
Cdd:COG2319 271 RLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGtVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGkTLASGSD 350

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 4505895  433 NGTMHLWDWRTGynfqrvhaaVQPGSLDSESG-IFACAFDQSESRLLTAEADKTIKVYR 490
Cdd:COG2319 351 DGTVRLWDLATG---------ELLRTLTGHTGaVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 pfam00400
WD domain, G-beta repeat;
194-232 1.74e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.12  E-value: 1.74e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 4505895    194 WKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWD 232
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 193-232 2.69e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.70  E-value: 2.69e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 4505895     193 PWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWD 232
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 192-358 4.31e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 49.12  E-value: 4.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505895   192 PPwklyrVISGHLGWVRCIAVEP-GNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGV-----IVS---TRSPYLF 262
Cdd:PTZ00421  68 PP-----ILLGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHtkkvgIVSfhpSAMNVLA 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505895   263 SCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAvATVRCQAAE 342
Cdd:PTZ00421 143 SAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASA-KSQRCLWAK 221

                        170       180
                 ....*....|....*....|..
gi 4505895   343 PQ--IIT----GSHDTTIRLWD 358
Cdd:PTZ00421 222 RKdlIITlgcsKSQQRQIMLWD 243
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 196-490 8.89e-89

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 274.21  E-value: 8.89e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505895  196 LYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDL 275
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505895  276 EYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIR 355
Cdd:cd00200  81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505895  356 LWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQNLSGHNAIINTLTVNSDG-VLVSGADN 433
Cdd:cd00200 161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGtIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGyLLASGSED 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 4505895  434 GTMHLWDWRTGYNFQRVHAavqpgsldSESGIFACAFDQSESRLLTAEADKTIKVYR 490
Cdd:cd00200 241 GTIRVWDLRTGECVQTLSG--------HTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
195-490 4.44e-69

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 227.10  E-value: 4.44e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505895  195 KLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWD 274
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505895  275 LEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTI 354
Cdd:COG2319 191 LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV 270

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505895  355 RLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQNLSGHNAIINTLTVNSDG-VLVSGAD 432
Cdd:COG2319 271 RLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGtVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGkTLASGSD 350

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 4505895  433 NGTMHLWDWRTGynfqrvhaaVQPGSLDSESG-IFACAFDQSESRLLTAEADKTIKVYR 490
Cdd:COG2319 351 DGTVRLWDLATG---------ELLRTLTGHTGaVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
190-443 3.11e-64

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 214.39  E-value: 3.11e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505895  190 WHPP-WKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDK 268
Cdd:COG2319 147 WDLAtGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADG 226

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505895  269 QVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITG 348
Cdd:COG2319 227 TVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASG 306

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505895  349 SHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQNLSGHNAIINTLTVNSDG-V 426
Cdd:COG2319 307 SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGtVRLWDLATGELLRTLTGHTGAVTSVAFSPDGrT 386

                       250
                ....*....|....*..
gi 4505895  427 LVSGADNGTMHLWDWRT 443
Cdd:COG2319 387 LASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
187-498 4.63e-62

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 208.61  E-value: 4.63e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505895  187 KPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGE 266
Cdd:COG2319  61 LLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSA 140

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505895  267 DKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQII 346
Cdd:COG2319 141 DGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLA 220

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505895  347 TGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQNLSGHNAIINTLTVNSDG 425
Cdd:COG2319 221 SGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGtVRLWDLATGELLRTLTGHSGGVNSVAFSPDG 300

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4505895  426 -VLVSGADNGTMHLWDWRTGYNFQRVHAavqpgsldSESGIFACAFDQSESRLLTAEADKTIKVYredDTATEE 498
Cdd:COG2319 301 kLLASGSDDGTVRLWDLATGKLLRTLTG--------HTGAVRSVAFSPDGKTLASGSDDGTVRLW---DLATGE 363
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 195-399 2.58e-54

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 184.46  E-value: 2.58e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505895  195 KLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWD 274
Cdd:cd00200  84 ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD 163

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505895  275 LEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVrcqAAEPQ---IITGSHD 351
Cdd:cd00200 164 LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSV---AFSPDgylLASGSED 240

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 4505895  352 TTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDN-IKQWK 399
Cdd:cd00200 241 GTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGtIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
198-499 3.99e-54

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 187.43  E-value: 3.99e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505895  198 RVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEY 277
Cdd:COG2319  30 LLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505895  278 NKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLW 357
Cdd:COG2319 110 GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505895  358 DLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQNLSGHNAIINTLTVNSDG-VLVSGADNGT 435
Cdd:COG2319 190 DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGtVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGrLLASGSADGT 269

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4505895  436 MHLWDWRTGynfQRVHAAVQPGsldseSGIFACAFDQSESRLLTAEADKTIKVYredDTATEET 499
Cdd:COG2319 270 VRLWDLATG---ELLRTLTGHS-----GGVNSVAFSPDGKLLASGSDDGTVRLW---DLATGKL 322
WD40 COG2319
WD40 repeat [General function prediction only];
211-498 7.27e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 162.77  E-value: 7.27e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505895  211 AVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSA 290
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505895  291 VYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTN 370
Cdd:COG2319  81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505895  371 HKKSVRAVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQNLSGHNAIINTLTVNSDG-VLVSGADNGTMHLWDWRTGYNFQ 448
Cdd:COG2319 161 HSGAVTSVAFSPDGKLLASGSDDGtVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGkLLASGSADGTVRLWDLATGKLLR 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 4505895  449 RVHAavqpgsldSESGIFACAFDQSESRLLTAEADKTIKVYredDTATEE 498
Cdd:COG2319 241 TLTG--------HSGSVRSVAFSPDGRLLASGSADGTVRLW---DLATGE 279
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 194-316 9.08e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 120.90  E-value: 9.08e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505895  194 WKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCW 273
Cdd:cd00200 167 GKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVW 246

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 4505895  274 DLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWD 316
Cdd:cd00200 247 DLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 pfam00400
WD domain, G-beta repeat;
194-232 1.74e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.12  E-value: 1.74e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 4505895    194 WKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWD 232
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 193-232 2.69e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.70  E-value: 2.69e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 4505895     193 PWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWD 232
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 279-316 4.51e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 4.51e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 4505895     279 KVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWD 316
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
278-316 1.37e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 1.37e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 4505895    278 NKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWD 316
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 192-358 4.31e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 49.12  E-value: 4.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505895   192 PPwklyrVISGHLGWVRCIAVEP-GNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGV-----IVS---TRSPYLF 262
Cdd:PTZ00421  68 PP-----ILLGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHtkkvgIVSfhpSAMNVLA 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505895   263 SCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAvATVRCQAAE 342
Cdd:PTZ00421 143 SAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASA-KSQRCLWAK 221

                        170       180
                 ....*....|....*....|..
gi 4505895   343 PQ--IIT----GSHDTTIRLWD 358
Cdd:PTZ00421 222 RKdlIITlgcsKSQQRQIMLWD 243
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 235-274 6.01e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 6.01e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 4505895     235 SGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWD 274
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
323-358 8.18e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 8.18e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 4505895    323 VHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWD 358
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 319-358 9.81e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 9.81e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 4505895     319 TKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWD 358
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
236-274 2.18e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 2.18e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 4505895    236 GKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWD 274
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 309-440 2.47e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.00  E-value: 2.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505895   309 DSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQII-TGSHDTTIRLWDLVAGKTRVTLTNhkKSVRAVVLHPRHY-- 385
Cdd:PLN00181 554 EGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLaSGSDDGSVKLWSINQGVSIGTIKT--KANICCVQFPSESgr 631

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4505895   386 TFASGSPD------NIKQWKFPDGSFIqnlsGHNAIINTLTVNSDGVLVSGADNGTMHLWD 440
Cdd:PLN00181 632 SLAFGSADhkvyyyDLRNPKLPLCTMI----GHSKTVSYVRFVDSSTLVSSSTDNTLKLWD 688
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 402-440 1.51e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 1.51e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 4505895     402 DGSFIQNLSGHNAIINTLTVNSDG-VLVSGADNGTMHLWD 440
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGkYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 225-359 1.63e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 44.31  E-value: 1.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505895   225 DRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCG-EDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVL 303
Cdd:PLN00181 554 EGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGsDDGSVKLWSINQGVSIGTIKTKANICCVQFPSESGRSL 633

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 4505895   304 VTCSRDSTARIWDVRT-KASVHTLSGHTNAVATVRCqAAEPQIITGSHDTTIRLWDL 359
Cdd:PLN00181 634 AFGSADHKVYYYDLRNpKLPLCTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLWDL 689
WD40 pfam00400
WD domain, G-beta repeat;
403-440 3.13e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 3.13e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 4505895    403 GSFIQNLSGHNAIINTLTVNSDG-VLVSGADNGTMHLWD 440
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGkLLASGSDDGTVKVWD 39
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 323-435 5.18e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 39.28  E-value: 5.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505895    323 VHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKtrvtlTNHKKSVRAVVLHPRHYTFASGSPDNIkqwkfpd 402
Cdd:pfam20426 117 VQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGR-----SSEKRSRNTQTEFPRKDHVIAETPFHI------- 184

                          90       100       110
                  ....*....|....*....|....*....|....
gi 4505895    403 gsfiqnLSGHNAIINTLTVNSD-GVLVSGADNGT 435
Cdd:pfam20426 185 ------LCGHDDIITCLYVSVElDIVISGSKDGT 212
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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