G1/S-specific cyclin-D2 [Mus musculus]
List of domain hits
Name | Accession | Description | Interval | E-value | |||
CYCLIN_SF super family | cl40454 | Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ... |
1-149 | 6.45e-110 | |||
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box. The actual alignment was detected with superfamily member cd20574: Pssm-ID: 477360 Cd Length: 150 Bit Score: 314.62 E-value: 6.45e-110
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CYCLIN_CCND2_rpt2 | cd20577 | second cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ... |
154-258 | 1.30e-67 | |||
second cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain. : Pssm-ID: 410280 Cd Length: 105 Bit Score: 205.46 E-value: 1.30e-67
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Name | Accession | Description | Interval | E-value | ||||
CYCLIN_CCND2_rpt1 | cd20574 | first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ... |
1-149 | 6.45e-110 | ||||
first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410277 Cd Length: 150 Bit Score: 314.62 E-value: 6.45e-110
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CYCLIN_CCND2_rpt2 | cd20577 | second cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ... |
154-258 | 1.30e-67 | ||||
second cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain. Pssm-ID: 410280 Cd Length: 105 Bit Score: 205.46 E-value: 1.30e-67
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Cyclin_N | pfam00134 | Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ... |
24-151 | 6.70e-47 | ||||
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain. Pssm-ID: 459686 [Multi-domain] Cd Length: 127 Bit Score: 153.44 E-value: 6.70e-47
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Cyclin_C | pfam02984 | Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ... |
153-262 | 2.78e-20 | ||||
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain. Pssm-ID: 397230 Cd Length: 119 Bit Score: 83.83 E-value: 2.78e-20
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CYCLIN | smart00385 | domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ... |
60-143 | 1.35e-15 | ||||
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control. Pssm-ID: 214641 [Multi-domain] Cd Length: 83 Bit Score: 70.31 E-value: 1.35e-15
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COG5024 | COG5024 | Cyclin [Cell division and chromosome partitioning]; |
29-237 | 4.40e-15 | ||||
Cyclin [Cell division and chromosome partitioning]; Pssm-ID: 227357 [Multi-domain] Cd Length: 440 Bit Score: 74.81 E-value: 4.40e-15
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ccl1 | TIGR00569 | cyclin ccl1; All proteins in this family for which functions are known are cyclins that are ... |
74-206 | 5.09e-05 | ||||
cyclin ccl1; All proteins in this family for which functions are known are cyclins that are components of TFIIH, a complex that is involved in nucleotide excision repair and transcription initiation. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, StanfordUniversity). [DNA metabolism, DNA replication, recombination, and repair] Pssm-ID: 129660 [Multi-domain] Cd Length: 305 Bit Score: 44.05 E-value: 5.09e-05
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Name | Accession | Description | Interval | E-value | ||||
CYCLIN_CCND2_rpt1 | cd20574 | first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ... |
1-149 | 6.45e-110 | ||||
first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410277 Cd Length: 150 Bit Score: 314.62 E-value: 6.45e-110
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CYCLIN_CCND_rpt1 | cd20515 | first cyclin box found in cyclin-D (CCND) family; The CCND family includes three ... |
3-149 | 2.47e-98 | ||||
first cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410219 Cd Length: 150 Bit Score: 284.96 E-value: 2.47e-98
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CYCLIN_CCND3_rpt1 | cd20575 | first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a ... |
2-149 | 4.50e-87 | ||||
first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410278 Cd Length: 150 Bit Score: 256.84 E-value: 4.50e-87
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CYCLIN_CCND1_rpt1 | cd20573 | first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ... |
1-149 | 8.43e-87 | ||||
first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410276 Cd Length: 149 Bit Score: 256.06 E-value: 8.43e-87
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CYCLIN_CCND2_rpt2 | cd20577 | second cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ... |
154-258 | 1.30e-67 | ||||
second cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain. Pssm-ID: 410280 Cd Length: 105 Bit Score: 205.46 E-value: 1.30e-67
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Cyclin_N | pfam00134 | Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ... |
24-151 | 6.70e-47 | ||||
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain. Pssm-ID: 459686 [Multi-domain] Cd Length: 127 Bit Score: 153.44 E-value: 6.70e-47
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CYCLIN_CCND3_rpt2 | cd20578 | second cyclin box found in G1/S-specific cyclin-D3 (CCND3); CCND3 is a regulatory component of ... |
156-262 | 3.05e-46 | ||||
second cyclin box found in G1/S-specific cyclin-D3 (CCND3); CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain. Pssm-ID: 410281 Cd Length: 105 Bit Score: 150.98 E-value: 3.05e-46
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CYCLIN_CCND_rpt2 | cd20516 | second cyclin box found in cyclin-D (CCND) family; The CCND family includes three ... |
154-253 | 2.59e-44 | ||||
second cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain. Pssm-ID: 410220 Cd Length: 98 Bit Score: 145.83 E-value: 2.59e-44
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CYCLIN_CCND1_rpt2 | cd20576 | second cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ... |
154-266 | 3.98e-41 | ||||
second cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain. Pssm-ID: 410279 Cd Length: 110 Bit Score: 138.16 E-value: 3.98e-41
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CYCLIN_CCNA_rpt1 | cd20504 | first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ... |
23-147 | 9.86e-28 | ||||
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410208 [Multi-domain] Cd Length: 128 Bit Score: 103.87 E-value: 9.86e-28
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CYCLIN_AtCycA_like_rpt1 | cd20562 | first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ... |
27-148 | 7.29e-25 | ||||
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410265 Cd Length: 136 Bit Score: 96.71 E-value: 7.29e-25
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CYCLIN_CCNE_rpt1 | cd20519 | first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ... |
25-148 | 5.46e-24 | ||||
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410223 Cd Length: 131 Bit Score: 94.30 E-value: 5.46e-24
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CYCLIN_CCNE1_rpt1 | cd20579 | first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ... |
22-148 | 7.38e-21 | ||||
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410282 [Multi-domain] Cd Length: 137 Bit Score: 86.09 E-value: 7.38e-21
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Cyclin_C | pfam02984 | Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ... |
153-262 | 2.78e-20 | ||||
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain. Pssm-ID: 397230 Cd Length: 119 Bit Score: 83.83 E-value: 2.78e-20
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CYCLIN_CCNA2_rpt1 | cd20561 | first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S ... |
15-149 | 1.44e-19 | ||||
first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410264 [Multi-domain] Cd Length: 131 Bit Score: 82.41 E-value: 1.44e-19
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CYCLIN_CCNE2_rpt1 | cd20580 | first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ... |
23-148 | 3.23e-19 | ||||
first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410283 [Multi-domain] Cd Length: 137 Bit Score: 81.82 E-value: 3.23e-19
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CYCLIN_vCyC_rpt1 | cd20517 | first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle ... |
54-148 | 9.72e-19 | ||||
first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle progression and apoptotic signaling pathways. It forms an active kinase complex with cellular CDK6, a cellular cyclin-dependent kinase known to interact with cellular type D cyclins. v-Cyclin belongs to Cyclin D subfamily. It contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410221 Cd Length: 99 Bit Score: 79.14 E-value: 9.72e-19
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CYCLIN_CCNB1-like_rpt1 | cd20507 | first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ... |
27-147 | 7.05e-18 | ||||
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410211 [Multi-domain] Cd Length: 130 Bit Score: 77.95 E-value: 7.05e-18
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CYCLIN_CCNA1_rpt1 | cd20560 | first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ... |
23-143 | 2.71e-17 | ||||
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410263 Cd Length: 163 Bit Score: 77.19 E-value: 2.71e-17
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CYCLIN_CNTD2 | cd20542 | cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ... |
55-150 | 5.85e-17 | ||||
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain. Pssm-ID: 410245 [Multi-domain] Cd Length: 96 Bit Score: 74.28 E-value: 5.85e-17
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CYCLIN | smart00385 | domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ... |
60-143 | 1.35e-15 | ||||
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control. Pssm-ID: 214641 [Multi-domain] Cd Length: 83 Bit Score: 70.31 E-value: 1.35e-15
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COG5024 | COG5024 | Cyclin [Cell division and chromosome partitioning]; |
29-237 | 4.40e-15 | ||||
Cyclin [Cell division and chromosome partitioning]; Pssm-ID: 227357 [Multi-domain] Cd Length: 440 Bit Score: 74.81 E-value: 4.40e-15
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CYCLIN_AtCycB-like_rpt1 | cd20567 | first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ... |
42-148 | 4.68e-14 | ||||
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410270 Cd Length: 147 Bit Score: 68.14 E-value: 4.68e-14
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CYCLIN_CLBs_yeast_rpt1 | cd20568 | first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ... |
33-148 | 2.33e-13 | ||||
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410271 Cd Length: 134 Bit Score: 65.78 E-value: 2.33e-13
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CYCLIN_CCNB3_rpt1 | cd20508 | first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is ... |
47-147 | 4.57e-13 | ||||
first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410212 [Multi-domain] Cd Length: 142 Bit Score: 64.97 E-value: 4.57e-13
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CYCLIN_SF | cd00043 | Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ... |
58-140 | 1.82e-11 | ||||
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box. Pssm-ID: 410207 [Multi-domain] Cd Length: 82 Bit Score: 58.96 E-value: 1.82e-11
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CYCLIN_CCNI-like | cd20526 | cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ... |
55-150 | 7.94e-11 | ||||
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain. Pssm-ID: 410230 Cd Length: 99 Bit Score: 57.71 E-value: 7.94e-11
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CYCLIN_CCNO_rpt1 | cd20536 | first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required ... |
54-146 | 1.03e-10 | ||||
first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410239 Cd Length: 93 Bit Score: 57.34 E-value: 1.03e-10
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CYCLIN_AtCycD-like_rpt1 | cd20543 | first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ... |
61-148 | 2.40e-10 | ||||
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410246 Cd Length: 99 Bit Score: 56.56 E-value: 2.40e-10
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CYCLIN_CCNJ-like_rpt1 | cd20528 | first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ... |
51-148 | 2.63e-10 | ||||
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410231 [Multi-domain] Cd Length: 103 Bit Score: 56.46 E-value: 2.63e-10
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CYCLIN_CCNB1_rpt1 | cd20565 | first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the ... |
48-148 | 2.65e-10 | ||||
first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410268 [Multi-domain] Cd Length: 129 Bit Score: 57.20 E-value: 2.65e-10
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CYCLIN_CCNB2_rpt1 | cd20566 | first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is ... |
36-148 | 1.08e-09 | ||||
first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410269 [Multi-domain] Cd Length: 133 Bit Score: 55.64 E-value: 1.08e-09
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CYCLIN_CCNF_rpt1 | cd20521 | first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also ... |
54-135 | 9.23e-09 | ||||
first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410225 Cd Length: 95 Bit Score: 51.93 E-value: 9.23e-09
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CYCLIN_AtCycD-like_rpt2 | cd20544 | second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant ... |
153-249 | 1.23e-08 | ||||
second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain. Pssm-ID: 410247 Cd Length: 90 Bit Score: 51.54 E-value: 1.23e-08
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CYCLIN_ScCLN_like | cd20559 | cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ... |
75-149 | 1.71e-06 | ||||
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain. Pssm-ID: 410262 [Multi-domain] Cd Length: 95 Bit Score: 45.45 E-value: 1.71e-06
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CCL1 | COG5333 | Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ... |
78-216 | 1.68e-05 | ||||
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]; Pssm-ID: 227640 [Multi-domain] Cd Length: 297 Bit Score: 45.49 E-value: 1.68e-05
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CYCLIN_CABLES | cd20556 | cyclin box found in CDK5 and ABL1 enzyme substrate (CABLES) family; The CABLES family includes ... |
62-164 | 3.25e-05 | ||||
cyclin box found in CDK5 and ABL1 enzyme substrate (CABLES) family; The CABLES family includes CABLES1 and CABLES2. CABLES1, also called interactor with CDK3 1 (Ik3-1), is a cyclin-dependent kinase binding protein that enhances cyclin-dependent kinase tyrosine phosphorylation by non-receptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. CABLES2, also called interactor with CDK3 2 (Ik3-2), acts as a proapoptotic factor involved in both p53-mediated and p53-independent apoptotic pathways. Both, CABLES1 and CABLES2, contain one cyclin box. The cyclin box is a protein binding domain. Pssm-ID: 410259 Cd Length: 119 Bit Score: 42.55 E-value: 3.25e-05
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CYCLIN_CCNG1 | cd20583 | cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has ... |
74-148 | 3.78e-05 | ||||
cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG1 contains one cyclin box. The cyclin box is a protein binding domain. Pssm-ID: 410286 Cd Length: 98 Bit Score: 41.73 E-value: 3.78e-05
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ccl1 | TIGR00569 | cyclin ccl1; All proteins in this family for which functions are known are cyclins that are ... |
74-206 | 5.09e-05 | ||||
cyclin ccl1; All proteins in this family for which functions are known are cyclins that are components of TFIIH, a complex that is involved in nucleotide excision repair and transcription initiation. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, StanfordUniversity). [DNA metabolism, DNA replication, recombination, and repair] Pssm-ID: 129660 [Multi-domain] Cd Length: 305 Bit Score: 44.05 E-value: 5.09e-05
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CYCLIN_CCNO-like_rpt2 | cd20537 | second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of ... |
153-249 | 1.28e-04 | ||||
second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of CCNO and similar proteins including Schizosaccharomyces pombe meiosis-specific cyclin rem1, Drosophila melanogaster G2/mitotic-specific cyclin-A (CCNA), and Candida albicans G1/S-specific cyclin CCN1, among others. Rem1 is required for pre-meiotic DNA synthesis and S phase progression. CCNA is essential for the control of the cell cycle at the G2/M (mitosis) transition. CCN1 is essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It is involved in the activation of cyclin-dependent kinase 2. Members of this subfamily contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain. Pssm-ID: 410240 [Multi-domain] Cd Length: 91 Bit Score: 39.98 E-value: 1.28e-04
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CYCLIN_CCNG | cd20523 | cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 ... |
74-146 | 2.88e-04 | ||||
cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 and CCNG2. CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. Members of this family contain one cyclin box. The cyclin box is a protein binding domain. Pssm-ID: 410227 Cd Length: 94 Bit Score: 39.26 E-value: 2.88e-04
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CYCLIN_ScCTK2-like_rpt1 | cd20547 | first cyclin box found in Saccharomyces cerevisiae CTD kinase subunit 2 (ScCTK2) and similar ... |
54-127 | 1.43e-03 | ||||
first cyclin box found in Saccharomyces cerevisiae CTD kinase subunit 2 (ScCTK2) and similar proteins; CTK2, also called CTD kinase subunit beta, CTDK-I subunit beta, or CTD kinase 38 kDa subunit, is the cyclin subunit of the CTDK-I complex, which hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit. CTK2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410250 [Multi-domain] Cd Length: 110 Bit Score: 37.71 E-value: 1.43e-03
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CYCLIN_CCNG2 | cd20584 | cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth ... |
71-113 | 2.92e-03 | ||||
cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. CCNG2 contains one cyclin box. The cyclin box is a protein binding domain. Pssm-ID: 410287 Cd Length: 96 Bit Score: 36.36 E-value: 2.92e-03
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