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Conserved domains on  [gi|7706186|ref|NP_057723|]
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tumor necrosis factor receptor superfamily member 12A precursor [Homo sapiens]

Protein Classification

tumor necrosis factor receptor family protein( domain architecture ID 11192579)

tumor necrosis factor receptor (TNFR) family protein may interact with TNF superfamily (TNFSF) ligands (TNFL) to control key cellular processes such as differentiation, proliferation, apoptosis, and cell growth; similar to Rattus norvegicus tumor necrosis factor receptor superfamily member 8

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
stn_TNFRSF12A pfam12191
Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain; This family of proteins is found in ...
 23-129 2.78e-67

Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain; This family of proteins is found in eukaryotes. Proteins in this family are typically between 129 and 184 amino acids in length. This is the stn_TNFRSF12A_TNFR domain from the tumour necrosis factor receptor. The function of this domain is unknown.


:

Pssm-ID: 403424  Cd Length: 129  Bit Score: 199.06  E-value: 2.78e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706186     23 RSVAGEQAPGTAPCSRGSSWSADLDKCMDCASCRARPHSDFCLGCAAAPPAPFRLLWPILGGALSLTFVLGLLSGFLVWR 102
Cdd:pfam12191  23 HAAAGEQAPGNAPCSRGSSWSADLDKCMDCASCPARPHSDFCLGCAAAPPAHFRLLWPILGGALSLALVLGLLSGFLVWR 102

                          90       100
                  ....*....|....*....|....*..
gi 7706186    103 RCRRREKFTTPIEETGGEGCPAVALIQ 129
Cdd:pfam12191 103 RCRRREKFTTPIEETGGEGCPGVALIQ 129
 
Name Accession Description Interval E-value
stn_TNFRSF12A pfam12191
Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain; This family of proteins is found in ...
 23-129 2.78e-67

Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain; This family of proteins is found in eukaryotes. Proteins in this family are typically between 129 and 184 amino acids in length. This is the stn_TNFRSF12A_TNFR domain from the tumour necrosis factor receptor. The function of this domain is unknown.


Pssm-ID: 403424  Cd Length: 129  Bit Score: 199.06  E-value: 2.78e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706186     23 RSVAGEQAPGTAPCSRGSSWSADLDKCMDCASCRARPHSDFCLGCAAAPPAPFRLLWPILGGALSLTFVLGLLSGFLVWR 102
Cdd:pfam12191  23 HAAAGEQAPGNAPCSRGSSWSADLDKCMDCASCPARPHSDFCLGCAAAPPAHFRLLWPILGGALSLALVLGLLSGFLVWR 102

                          90       100
                  ....*....|....*....|....*..
gi 7706186    103 RCRRREKFTTPIEETGGEGCPAVALIQ 129
Cdd:pfam12191 103 RCRRREKFTTPIEETGGEGCPGVALIQ 129
TNFRSF12A cd13413
Tumor necrosis factor receptor superfamily member 12A (TNFRSFA), also known as receptor ...
 25-126 1.77e-54

Tumor necrosis factor receptor superfamily member 12A (TNFRSFA), also known as receptor fibroblast growth factor inducible 14 (FN14); TNFRSF12A (also known as receptor fibroblast growth factor inducible 14, FN14, CD266, TWEAKR) is induced by a large variety of growth factors including Fibroblast Growth Factor 1 (FGF1), FGF2, Platelet-Derived Growth Factor (PDGF), Epidermal Growth Factor (EGF) and Vascular Endothelial Growth Factor (VEGF), as well as cytokines such as tumor necrosis factor alpha (TNFalpha), Interleukin-1beta (IL-1beta), Interferon gamma (IFNgamma), and transforming growth factor-beta (TGF-beta). FN14 is expressed on a wide variety of different cell types and binds the ligand TWEAK (tumor necrosis factor-like weak inducer of apoptosis) to activate several signaling cascades through activation of NF-kappaB signaling mediated by adaptor TRAF proteins. The FN14/TWEAK pathway controls a range of cellular activities such as proliferation, differentiation, and apoptosis, and has diverse biological functions in pathological mechanisms like inflammation and fibrosis that are associated with cardiovascular diseases (CVDs). The complex is a positive regulator of cardiac hypertrophy and it has been shown that deletion of FN14 receptor protects from right heart fibrosis and dysfunction; the TWEAK/Fn14 axis could be a potential new therapeutic target for achieving cardiac protection in patients with CVDs. FN14 expression is also stimulated under specific atrophic conditions, such as denervation, immobilization, and starvation, leading to activation of TWEAK/Fn14 signaling and eventually skeletal muscle atrophy. FN14 is also a factor that promotes prostate cancer bone metastasis.


Pssm-ID: 276918  Cd Length: 117  Bit Score: 166.49  E-value: 1.77e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706186   25 VAGEQAPGTAPCSRGSSWSADLDKCMDCASCRARPHSDFCLGCAAAPPAPFRLLWPILGGALSLTFVLGLLSGFLVWRRC 104
Cdd:cd13413  16 SAAGQAAATSPCPGGSSWSPDLDKCMDCSSCPARPKSDFCLGCGAAPPPPFPLLWPILGGALGLVLLLALLSGTLVWRRC 95

                        90       100
                ....*....|....*....|..
gi 7706186  105 RRREKFTTPIEETGGEGCPAVA 126
Cdd:cd13413  96 RRREKFTTPIEETGGEGCPGVA 117
 
Name Accession Description Interval E-value
stn_TNFRSF12A pfam12191
Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain; This family of proteins is found in ...
 23-129 2.78e-67

Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain; This family of proteins is found in eukaryotes. Proteins in this family are typically between 129 and 184 amino acids in length. This is the stn_TNFRSF12A_TNFR domain from the tumour necrosis factor receptor. The function of this domain is unknown.


Pssm-ID: 403424  Cd Length: 129  Bit Score: 199.06  E-value: 2.78e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706186     23 RSVAGEQAPGTAPCSRGSSWSADLDKCMDCASCRARPHSDFCLGCAAAPPAPFRLLWPILGGALSLTFVLGLLSGFLVWR 102
Cdd:pfam12191  23 HAAAGEQAPGNAPCSRGSSWSADLDKCMDCASCPARPHSDFCLGCAAAPPAHFRLLWPILGGALSLALVLGLLSGFLVWR 102

                          90       100
                  ....*....|....*....|....*..
gi 7706186    103 RCRRREKFTTPIEETGGEGCPAVALIQ 129
Cdd:pfam12191 103 RCRRREKFTTPIEETGGEGCPGVALIQ 129
TNFRSF12A cd13413
Tumor necrosis factor receptor superfamily member 12A (TNFRSFA), also known as receptor ...
 25-126 1.77e-54

Tumor necrosis factor receptor superfamily member 12A (TNFRSFA), also known as receptor fibroblast growth factor inducible 14 (FN14); TNFRSF12A (also known as receptor fibroblast growth factor inducible 14, FN14, CD266, TWEAKR) is induced by a large variety of growth factors including Fibroblast Growth Factor 1 (FGF1), FGF2, Platelet-Derived Growth Factor (PDGF), Epidermal Growth Factor (EGF) and Vascular Endothelial Growth Factor (VEGF), as well as cytokines such as tumor necrosis factor alpha (TNFalpha), Interleukin-1beta (IL-1beta), Interferon gamma (IFNgamma), and transforming growth factor-beta (TGF-beta). FN14 is expressed on a wide variety of different cell types and binds the ligand TWEAK (tumor necrosis factor-like weak inducer of apoptosis) to activate several signaling cascades through activation of NF-kappaB signaling mediated by adaptor TRAF proteins. The FN14/TWEAK pathway controls a range of cellular activities such as proliferation, differentiation, and apoptosis, and has diverse biological functions in pathological mechanisms like inflammation and fibrosis that are associated with cardiovascular diseases (CVDs). The complex is a positive regulator of cardiac hypertrophy and it has been shown that deletion of FN14 receptor protects from right heart fibrosis and dysfunction; the TWEAK/Fn14 axis could be a potential new therapeutic target for achieving cardiac protection in patients with CVDs. FN14 expression is also stimulated under specific atrophic conditions, such as denervation, immobilization, and starvation, leading to activation of TWEAK/Fn14 signaling and eventually skeletal muscle atrophy. FN14 is also a factor that promotes prostate cancer bone metastasis.


Pssm-ID: 276918  Cd Length: 117  Bit Score: 166.49  E-value: 1.77e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706186   25 VAGEQAPGTAPCSRGSSWSADLDKCMDCASCRARPHSDFCLGCAAAPPAPFRLLWPILGGALSLTFVLGLLSGFLVWRRC 104
Cdd:cd13413  16 SAAGQAAATSPCPGGSSWSPDLDKCMDCSSCPARPKSDFCLGCGAAPPPPFPLLWPILGGALGLVLLLALLSGTLVWRRC 95

                        90       100
                ....*....|....*....|..
gi 7706186  105 RRREKFTTPIEETGGEGCPAVA 126
Cdd:cd13413  96 RRREKFTTPIEETGGEGCPGVA 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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