NCBI Conserved Domain Search

NCBI

3D Macromolecular Structures

Conserved Domains

Conserved domains on [gi|21313638|ref|NP_060646|]

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leucine-rich repeat LGI family member 2 precursor [Homo sapiens]

Protein Classification

LRR_8 and EPTP domain-containing protein( domain architecture ID 12158096)

LRR_8 and EPTP domain-containing protein

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

LRR_8

Leucine rich repeat;

110-169

1.58e-13

Leucine rich repeat;

:

Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 65.24 E-value: 1.58e-13

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313638   110 HLEYLFIEGNKIETISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKF 169
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61

PCC super family

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...

140-215

7.50e-09

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.

The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 58.94 E-value: 7.50e-09

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21313638    140 LANNHIKALPRDVFSDLDSLIELDLRGNKFECDCKAKWLYLWLKMTNSTV---SDVLCIGPPEYQEKKLNDVTSFDYEC 215
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpEAALCAGPGALAGQPLLGIPLLDSGC 80

EPTP

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...

266-305

8.90e-09

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.

:

Pssm-ID: 461033 Cd Length: 41 Bit Score: 51.32 E-value: 8.90e-09

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 21313638   266 FRSYDNITGQSIVGCKAILIDDQVFVVVAQLFGGSHIYKY 305
Cdd:pfam03736   2 FVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41

EPTP

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...

452-492

1.06e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.

:

Pssm-ID: 461033 Cd Length: 41 Bit Score: 48.23 E-value: 1.06e-07

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 21313638   452 QFVEIQALPSRGAMTLQPFSFKDNHYLALGSDYTFSQIYQW 492
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41

EPTP

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...

311-356

1.14e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.

:

Pssm-ID: 461033 Cd Length: 41 Bit Score: 48.23 E-value: 1.14e-07

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 21313638   311 KFVKFQDIEVSRiskPNDIELFQIDDETFFVIADSSkaGLSTVYKW 356
Cdd:pfam03736   1 KFVPYQTIPTRG---ARDVEPFSIGGDLFLAVANFS--GDSVIYRW 41

EPTP

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...

407-448

1.25e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.

:

Pssm-ID: 461033 Cd Length: 41 Bit Score: 47.85 E-value: 1.25e-07

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 21313638   407 KFVPHGDIPNMeDVLAVKSFRMQNTLYLSLTRFIGDSRVMRW 448
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41

EPTP

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...

219-259

3.55e-06

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.

:

Pssm-ID: 461033 Cd Length: 41 Bit Score: 44.00 E-value: 3.55e-06

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 21313638   219 DFVVHQTLP-YQSVSVDTFNSKNDVYVAIAqPSMENCMVLEW 259
Cdd:pfam03736   1 KFVPYQTIPtRGARDVEPFSIGGDLFLAVA-NFSGDSVIYRW 41

EPTP

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...

360-401

4.64e-05

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.

:

Pssm-ID: 461033 Cd Length: 41 Bit Score: 40.53 E-value: 4.64e-05

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 21313638   360 GFYSYQSLHEWfRDTDAEFVDIDGKSHLILSSRSQVPIILQW 401
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41

EPTP

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...

499-538

1.70e-04

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.

:

Pssm-ID: 461033 Cd Length: 41 Bit Score: 38.99 E-value: 1.70e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 21313638   499 FKKFKEIYVQAPRSFTAVSTDRRDFFFASSFKGKTKIFEH 538
Cdd:pfam03736   2 FVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41

Name

Accession

Description

Interval

E-value

LRR_8

Leucine rich repeat;

110-169

1.58e-13

Leucine rich repeat;

Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 65.24 E-value: 1.58e-13

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313638   110 HLEYLFIEGNKIETISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKF 169
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61

LRR

Leucine-rich repeat (LRR) protein [Transcription];

102-170

4.43e-11

Leucine-rich repeat (LRR) protein [Transcription];

Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 64.95 E-value: 4.43e-11

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21313638 102 DDAFAGLFHLEYLFIEGNKIETISrNAFRGLRDLTHLSLANNHIKALPRDvFSDLDSLIELDLRGNKFE 170
Cdd:COG4886 175 PEELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLT 241

PCC

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...

140-215

7.50e-09

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.

Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 58.94 E-value: 7.50e-09

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21313638    140 LANNHIKALPRDVFSDLDSLIELDLRGNKFECDCKAKWLYLWLKMTNSTV---SDVLCIGPPEYQEKKLNDVTSFDYEC 215
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpEAALCAGPGALAGQPLLGIPLLDSGC 80

EPTP

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...

266-305

8.90e-09

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.

Pssm-ID: 461033 Cd Length: 41 Bit Score: 51.32 E-value: 8.90e-09

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 21313638   266 FRSYDNITGQSIVGCKAILIDDQVFVVVAQLFGGSHIYKY 305
Cdd:pfam03736   2 FVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41

EPTP

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...

452-492

1.06e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.

Pssm-ID: 461033 Cd Length: 41 Bit Score: 48.23 E-value: 1.06e-07

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 21313638   452 QFVEIQALPSRGAMTLQPFSFKDNHYLALGSDYTFSQIYQW 492
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41

EPTP

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...

311-356

1.14e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.

Pssm-ID: 461033 Cd Length: 41 Bit Score: 48.23 E-value: 1.14e-07

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 21313638   311 KFVKFQDIEVSRiskPNDIELFQIDDETFFVIADSSkaGLSTVYKW 356
Cdd:pfam03736   1 KFVPYQTIPTRG---ARDVEPFSIGGDLFLAVANFS--GDSVIYRW 41

EPTP

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...

407-448

1.25e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.

Pssm-ID: 461033 Cd Length: 41 Bit Score: 47.85 E-value: 1.25e-07

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 21313638   407 KFVPHGDIPNMeDVLAVKSFRMQNTLYLSLTRFIGDSRVMRW 448
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41

EPTP

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...

219-259

3.55e-06

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.

Pssm-ID: 461033 Cd Length: 41 Bit Score: 44.00 E-value: 3.55e-06

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 21313638   219 DFVVHQTLP-YQSVSVDTFNSKNDVYVAIAqPSMENCMVLEW 259
Cdd:pfam03736   1 KFVPYQTIPtRGARDVEPFSIGGDLFLAVA-NFSGDSVIYRW 41

PPP1R42

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...

111-167

3.25e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.

Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 45.16 E-value: 3.25e-05

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 21313638 111 LEYLFIEGNKIETISrnAFRGLRDLTHLSLANNHIKALPR--DVFSDLDSLIELDLRGN 167
Cdd:cd21340 122 LRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178

EPTP

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...

360-401

4.64e-05

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.

Pssm-ID: 461033 Cd Length: 41 Bit Score: 40.53 E-value: 4.64e-05

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 21313638   360 GFYSYQSLHEWfRDTDAEFVDIDGKSHLILSSRSQVPIILQW 401
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41

EPTP

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...

499-538

1.70e-04

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.

Pssm-ID: 461033 Cd Length: 41 Bit Score: 38.99 E-value: 1.70e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 21313638   499 FKKFKEIYVQAPRSFTAVSTDRRDFFFASSFKGKTKIFEH 538
Cdd:pfam03736   2 FVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41

LRRCT

Leucine rich repeat C-terminal domain;

167-216

2.10e-04

Leucine rich repeat C-terminal domain;

Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 39.34 E-value: 2.10e-04

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 21313638    167 NKFECDCKAKWLYLWLKMTNSTVS--DVLCIGPPEYQEKKLNDVTSFDYeCT 216
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDpvDLRCASPSSLRGPLLELLHSEFK-CP 51

LRR

Leucine-rich repeats, outliers;

132-155

1.49e-03

Leucine-rich repeats, outliers;

Pssm-ID: 197688 [Multi-domain] Cd Length: 24 Bit Score: 36.18 E-value: 1.49e-03

                           10        20
                   ....*....|....*....|....
gi 21313638    132 LRDLTHLSLANNHIKALPRDVFSD 155
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24

Name

Accession

Description

Interval

E-value

LRR_8

Leucine rich repeat;

110-169

1.58e-13

Leucine rich repeat;

Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 65.24 E-value: 1.58e-13

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313638   110 HLEYLFIEGNKIETISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKF 169
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61

LRR_8

Leucine rich repeat;

100-145

1.47e-11

Leucine rich repeat;

Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 59.85 E-value: 1.47e-11

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 21313638   100 IRDDAFAGLFHLEYLFIEGNKIETISRNAFRGLRDLTHLSLANNHI 145
Cdd:pfam13855  16 LDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61

LRR

Leucine-rich repeat (LRR) protein [Transcription];

102-170

4.43e-11

Leucine-rich repeat (LRR) protein [Transcription];

Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 64.95 E-value: 4.43e-11

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21313638 102 DDAFAGLFHLEYLFIEGNKIETISrNAFRGLRDLTHLSLANNHIKALPRDvFSDLDSLIELDLRGNKFE 170
Cdd:COG4886 175 PEELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLT 241

LRR

Leucine-rich repeat (LRR) protein [Transcription];

103-170

6.12e-10

Leucine-rich repeat (LRR) protein [Transcription];

Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 61.49 E-value: 6.12e-10

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21313638 103 DAFAGLFHLEYLFIEGNKIETISrNAFRGLRDLTHLSLANNHIKALPrdVFSDLDSLIELDLRGNKFE 170
Cdd:COG4886 199 EPLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLT 263

PCC

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...

140-215

7.50e-09

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.

Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 58.94 E-value: 7.50e-09

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21313638    140 LANNHIKALPRDVFSDLDSLIELDLRGNKFECDCKAKWLYLWLKMTNSTV---SDVLCIGPPEYQEKKLNDVTSFDYEC 215
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpEAALCAGPGALAGQPLLGIPLLDSGC 80

EPTP

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...

266-305

8.90e-09

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.

Pssm-ID: 461033 Cd Length: 41 Bit Score: 51.32 E-value: 8.90e-09

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 21313638   266 FRSYDNITGQSIVGCKAILIDDQVFVVVAQLFGGSHIYKY 305
Cdd:pfam03736   2 FVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41

LRR

Leucine-rich repeat (LRR) protein [Transcription];

103-180

8.93e-09

Leucine-rich repeat (LRR) protein [Transcription];

Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 57.64 E-value: 8.93e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313638 103 DAFAGLFHLEYLFIEGNKIETISrNAFRGLRDLTHLSLANNHIKALPrDVFSDLDSLIELDLRGNKFE------CDCKA- 175
Cdd:COG4886 107 EELSNLTNLESLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTdlpeelGNLTNl 184


                ....*
gi 21313638 176 KWLYL 180
Cdd:COG4886 185 KELDL 189

LRR

Leucine-rich repeat (LRR) protein [Transcription];

103-212

1.12e-08

Leucine-rich repeat (LRR) protein [Transcription];

Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 57.25 E-value: 1.12e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313638 103 DAFAGLFHLEYLFIEGNKIETISrnAFRGLRDLTHLSLANNHIKALPrdVFSDLDSLIELDLRGNKFEcDCKAKWLYLWL 182
Cdd:COG4886 222 EPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLT-DLKLKELELLL 296

                        90       100       110
                ....*....|....*....|....*....|
gi 21313638 183 KMTNSTVSDVLCIGPPEYQEKKLNDVTSFD 212
Cdd:COG4886 297 GLNSLLLLLLLLNLLELLILLLLLTTLLLL 326

EPTP

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...

452-492

1.06e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.

Pssm-ID: 461033 Cd Length: 41 Bit Score: 48.23 E-value: 1.06e-07

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 21313638   452 QFVEIQALPSRGAMTLQPFSFKDNHYLALGSDYTFSQIYQW 492
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41

EPTP

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...

311-356

1.14e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.

Pssm-ID: 461033 Cd Length: 41 Bit Score: 48.23 E-value: 1.14e-07

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 21313638   311 KFVKFQDIEVSRiskPNDIELFQIDDETFFVIADSSkaGLSTVYKW 356
Cdd:pfam03736   1 KFVPYQTIPTRG---ARDVEPFSIGGDLFLAVANFS--GDSVIYRW 41

EPTP

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...

407-448

1.25e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.

Pssm-ID: 461033 Cd Length: 41 Bit Score: 47.85 E-value: 1.25e-07

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 21313638   407 KFVPHGDIPNMeDVLAVKSFRMQNTLYLSLTRFIGDSRVMRW 448
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41

EPTP

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...

219-259

3.55e-06

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.

Pssm-ID: 461033 Cd Length: 41 Bit Score: 44.00 E-value: 3.55e-06

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 21313638   219 DFVVHQTLP-YQSVSVDTFNSKNDVYVAIAqPSMENCMVLEW 259
Cdd:pfam03736   1 KFVPYQTIPtRGARDVEPFSIGGDLFLAVA-NFSGDSVIYRW 41

PPP1R42

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...

111-167

3.25e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.

Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 45.16 E-value: 3.25e-05

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 21313638 111 LEYLFIEGNKIETISrnAFRGLRDLTHLSLANNHIKALPR--DVFSDLDSLIELDLRGN 167
Cdd:cd21340 122 LRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178

EPTP

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...

360-401

4.64e-05

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.

Pssm-ID: 461033 Cd Length: 41 Bit Score: 40.53 E-value: 4.64e-05

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 21313638   360 GFYSYQSLHEWfRDTDAEFVDIDGKSHLILSSRSQVPIILQW 401
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41

EPTP

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...

499-538

1.70e-04

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.

Pssm-ID: 461033 Cd Length: 41 Bit Score: 38.99 E-value: 1.70e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 21313638   499 FKKFKEIYVQAPRSFTAVSTDRRDFFFASSFKGKTKIFEH 538
Cdd:pfam03736   2 FVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41

LRRCT

Leucine rich repeat C-terminal domain;

167-216

2.10e-04

Leucine rich repeat C-terminal domain;

Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 39.34 E-value: 2.10e-04

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 21313638    167 NKFECDCKAKWLYLWLKMTNSTVS--DVLCIGPPEYQEKKLNDVTSFDYeCT 216
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDpvDLRCASPSSLRGPLLELLHSEFK-CP 51

LRR_4

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...

135-167

2.99e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.

Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 38.38 E-value: 2.99e-04

                          10        20        30
                  ....*....|....*....|....*....|...
gi 21313638   135 LTHLSLANNHIKALPrdVFSDLDSLIELDLRGN 167
Cdd:pfam12799   3 LEVLDLSNNQITDIP--PLAKLPNLETLDLSGN 33

LRR

Leucine-rich repeats, outliers;

132-155

1.49e-03

Leucine-rich repeats, outliers;

Pssm-ID: 197688 [Multi-domain] Cd Length: 24 Bit Score: 36.18 E-value: 1.49e-03

                           10        20
                   ....*....|....*....|....
gi 21313638    132 LRDLTHLSLANNHIKALPRDVFSD 155
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24

LRR_TYP

Leucine-rich repeats, typical (most populated) subfamily;

132-155

1.49e-03

Leucine-rich repeats, typical (most populated) subfamily;

Pssm-ID: 197687 [Multi-domain] Cd Length: 24 Bit Score: 36.18 E-value: 1.49e-03

                           10        20
                   ....*....|....*....|....
gi 21313638    132 LRDLTHLSLANNHIKALPRDVFSD 155
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24

PPP1R42

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...

113-168

4.51e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.

Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 38.61 E-value: 4.51e-03

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 21313638 113 YLFieGNKIETISrnAFRGLRDLTHLSLANNHIKALprDVFSDLDSLIELDLRGNK 168
Cdd:cd21340  30 YLY--DNKITKIE--NLEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNR 79

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01

References:

Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.

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of the residues that compose this conserved feature have been mapped to the query sequence.

Click on the triangle to view details about the feature, including a multiple sequence alignment of your query sequence and the protein sequences used to curate the domain model, where hash marks (#) above the aligned sequences show the location of the conserved feature residues.

The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions. Click on the triangle for interactive 3D structure viewing options.

Functional characterization of the conserved domain architecture found on the query. Click here to see more details.

This image shows a graphical summary of conserved domains identified on the query sequence. The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits (labeled illustration) or all hits (labeled illustration).
Domains are color coded according to superfamilies to which they have been assigned. Hits with scores that pass a domain-specific threshold (specific hits) are drawn in bright colors. Others (non-specific hits) and superfamily placeholders are drawn in pastel colors.
if a domain or superfamily has been annotated with functional sites (conserved features), they are mapped to the query sequence and indicated through sets of triangles with the same color and shade of the domain or superfamily that provides the annotation.
Mouse over the colored bars or triangles to see descriptions of the domains and features. click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.

The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores. Click on the domain model's accession number to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.

To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page, or click on the triangles, if present, that represent functional sites (conserved features) mapped to the query sequence.

Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence. (labeled illustration)
Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence. (labeled illustration)
Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance. (labeled illustration)
Four types of hits can be shown, as available, for each region on the query sequence:

specific hits meet or exceed a domain-specific e-value threshold (illustrated example) and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains

The CD-Search help document provides more detail about the tool and its features.

Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool (CDART).

Modify your query to search against a different database and/or use advanced search options