TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 18497288    929 CDSVLATNVTQQECCC-SLGAGWGDHCEiyPCPVYSSAEFHSLC 971
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCE--LCPPPGTDEFRELC 44

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 18497288     744 DVNECAEGSPCSPG-WCENLPGSFRCTCAQGYApapDGRSC 783
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNC 38

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30
                 ....*....|....*....|....*....|....*
gi 18497288  660 DLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLK 694
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGR 35

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 18497288   1099 GMCAGPLAGpALTFDDCCCR-QGRGWGAQCRPCPPRG 1134
Cdd:pfam00683    1 GRCSNPLPG-NVTKSECCCTsVGRAWGSPCELCPPPG 36

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 18497288     826 DIDECDFPAACI-GGDCINTNGSYRCLCPQGHRlvGGRKCQ 865
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT--DGRNCE 39

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....*
gi 18497288     703 DIDECRDPSSC-PDGKCENKPGSFKCIaCQPGYRS 736
Cdd:smart00179    1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGYTD 34

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30
                   ....*....|....*....|....*....|..
gi 18497288    291 SNPLPG-LTKQEDCCGSIGTAWGqSKCHKCPQ 321
Cdd:pfam00683    4 SNPLPGnVTKSECCCTSVGRAWG-SPCELCPP 34

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 18497288    929 CDSVLATNVTQQECCC-SLGAGWGDHCEiyPCPVYSSAEFHSLC 971
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCE--LCPPPGTDEFRELC 44

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 18497288     744 DVNECAEGSPCSPG-WCENLPGSFRCTCAQGYApapDGRSC 783
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNC 38

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30
                 ....*....|....*....|....*....|....*
gi 18497288  660 DLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLK 694
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGR 35

large tegument protein UL36; Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18497288   487 PPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSeERSVQQSHPTATTTPARPYPELISRP--SPPTMRWFLPDLPPSRSA 564
Cdd:PHA03247 2831 PTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVR-RRPPSRSPAAKPAAPARPPVRRLARPavSRSTESFALPPDQPERPP 2909

                          90
                  ....*....|...
gi 18497288   565 VEIAPTQVTETDE 577
Cdd:PHA03247 2910 QPQAPPPPQPQPQ 2922

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 18497288  785 DVDECEAGDVCDN-GICSNTPGSFQCQCLSGYHLSR 819
Cdd:cd00054    1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTGRN 36

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30
                 ....*....|....*....|....*....|..
gi 18497288  744 DVNECAEGSPCSP-GWCENLPGSFRCTCAQGY 774
Cdd:cd00054    1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGY 32

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 18497288     826 DIDECDFPAACI-GGDCINTNGSYRCLCPQGHRlvGGRKCQ 865
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT--DGRNCE 39

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 18497288  826 DIDECDFPAAC-IGGDCINTNGSYRCLCPQGHRlvgGRKCQ 865
Cdd:cd00054    1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYT---GRNCE 38

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 18497288    826 DIDECDFPAA-C-IGGDCINTNGSYRCLCPQG 855
Cdd:pfam07645    1 DVDECATGTHnCpANTVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30
                 ....*....|....*....|....*....|
gi 18497288 1036 DVDECLDESNCRN-GVCENTRGGYRCACTP 1064
Cdd:cd00054    1 DIDECASGNPCQNgGTCVNTVGSYRCSCPP 30

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....*
gi 18497288     703 DIDECRDPSSC-PDGKCENKPGSFKCIaCQPGYRS 736
Cdd:smart00179    1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGYTD 34

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 18497288  616 DVNECE-AEPCGPGrGICMNTGGSYNCHCNRGYRLH 650
Cdd:cd00054    1 DIDECAsGNPCQNG-GTCVNTVGSYRCSCPPGYTGR 35

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.

                           10        20
                   ....*....|....*....|..
gi 18497288    767 RCTCAQGYAPAPDGRSCLDVDE 788
Cdd:pfam12662    1 TCSCPPGYQLDPDGRTCVDIDE 22

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 18497288    1207 DIDECRELNqrglLCKS-ERCVNTSGSFRCVCKAGF 1241
Cdd:smart00179    1 DIDECASGN----PCQNgGTCVNTVGSYRCECPPGY 32

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 18497288    929 CDSVLATNVTQQECCC-SLGAGWGDHCEiyPCPVYSSAEFHSLC 971
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCE--LCPPPGTDEFRELC 44

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 18497288     744 DVNECAEGSPCSPG-WCENLPGSFRCTCAQGYApapDGRSC 783
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNC 38

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30
                 ....*....|....*....|....*....|....*
gi 18497288  660 DLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLK 694
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGR 35

large tegument protein UL36; Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18497288   487 PPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSeERSVQQSHPTATTTPARPYPELISRP--SPPTMRWFLPDLPPSRSA 564
Cdd:PHA03247 2831 PTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVR-RRPPSRSPAAKPAAPARPPVRRLARPavSRSTESFALPPDQPERPP 2909

                          90
                  ....*....|...
gi 18497288   565 VEIAPTQVTETDE 577
Cdd:PHA03247 2910 QPQAPPPPQPQPQ 2922

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 18497288  785 DVDECEAGDVCDN-GICSNTPGSFQCQCLSGYHLSR 819
Cdd:cd00054    1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTGRN 36

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30
                 ....*....|....*....|....*....|..
gi 18497288  744 DVNECAEGSPCSP-GWCENLPGSFRCTCAQGY 774
Cdd:cd00054    1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGY 32

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 18497288     826 DIDECDFPAACI-GGDCINTNGSYRCLCPQGHRlvGGRKCQ 865
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT--DGRNCE 39

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 18497288  826 DIDECDFPAAC-IGGDCINTNGSYRCLCPQGHRlvgGRKCQ 865
Cdd:cd00054    1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYT---GRNCE 38

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 18497288    826 DIDECDFPAA-C-IGGDCINTNGSYRCLCPQG 855
Cdd:pfam07645    1 DVDECATGTHnCpANTVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30
                 ....*....|....*....|....*....|
gi 18497288 1036 DVDECLDESNCRN-GVCENTRGGYRCACTP 1064
Cdd:cd00054    1 DIDECASGNPCQNgGTCVNTVGSYRCSCPP 30

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....*
gi 18497288     703 DIDECRDPSSC-PDGKCENKPGSFKCIaCQPGYRS 736
Cdd:smart00179    1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGYTD 34

Epidermal growth factor-like domain;

                            10        20        30
                    ....*....|....*....|....*....|...
gi 18497288     788 ECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRD 820
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYTGDKR 33

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 18497288  739 GGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRS 782
Cdd:cd01475  181 GKICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30
                 ....*....|....*....|....*....|....
gi 18497288  703 DIDECRDPSSC-PDGKCENKPGSFKCIaCQPGYR 735
Cdd:cd00054    1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGYT 33

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30
                   ....*....|....*....|....*....|..
gi 18497288    291 SNPLPG-LTKQEDCCGSIGTAWGqSKCHKCPQ 321
Cdd:pfam00683    4 SNPLPGnVTKSECCCTSVGRAWG-SPCELCPP 34

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 18497288    1207 DIDECRELNqrglLCKS-ERCVNTSGSFRCVCKAGF 1241
Cdd:smart00179    1 DIDECASGN----PCQNgGTCVNTVGSYRCECPPGY 32