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Conserved domains on  [gi|12746430|ref|NP_075541|]
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something about silencing protein 10 [Mus musculus]

Protein Classification

something about silencing 10 family protein( domain architecture ID 10512677)

something about silencing 10 (SAS10) family protein similar to human SAS10 that is essential for gene silencing and has a role in the structure of silenced chromatin

Gene Ontology:  GO:0003723|GO:1990904
PubMed:  9611201

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sas10 pfam09368
Sas10 C-terminal domain; Sas10 is an Essential subunit of U3-containing Small Subunit (SSU) ...
 398-468 5.49e-30

Sas10 C-terminal domain; Sas10 is an Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in the production of the 18S rRNA and assembly of the small ribosomal subunit.


:

Pssm-ID: 462775 [Multi-domain]  Cd Length: 74  Bit Score: 111.48  E-value: 5.49e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 12746430   398 KRAITYQIAKNRGLTPRRKKIDRNPRVKHREKFRKAKIRRRGQVREVRREEQRYSGELSGIRAGVKKSIKL 468
Cdd:pfam09368   4 KRKITYQIEKNKGLTPHRKKENRNPRVKKRYKYEKAKKKRKSQVRVVREEGGGYGGETTGIKTNVVRSVKL 74
Sas10_Utp3 pfam04000
Sas10/Utp3/C1D family; This family contains Utp3 and LCP5 which are components of the U3 ...
 226-306 2.16e-18

Sas10/Utp3/C1D family; This family contains Utp3 and LCP5 which are components of the U3 ribonucleoprotein complex. It also includes the human C1D protein and Saccharomyces cerevisiae YHR081W (rrp47), an exosome-associated protein required for the 3' processing of stable RNAs, and Sas10 which has been identified as a regulator of chromatin silencing. This family also includes the human protein Neuroguidin an initiation factor 4E (eIF4E) binding protein.


:

Pssm-ID: 461123  Cd Length: 83  Bit Score: 79.61  E-value: 2.16e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12746430   226 IEDLQAKLTEVKDELEPLLQLVEKGVIPT--GRGSEYLKTKYNLYLNYCANISFYLILKARRVPAHGHPVIERLVTYRNL 303
Cdd:pfam04000   1 LEELKKSLDELEESLEPLLKKVKNPTSKGlsEELPSLLRAKNHLLLAYLINLLFYLLLKLSGVSPKDHPVVKELVRLRVY 80


                  ...
gi 12746430   304 INK 306
Cdd:pfam04000  81 LEK 83
 
Name Accession Description Interval E-value
Sas10 pfam09368
Sas10 C-terminal domain; Sas10 is an Essential subunit of U3-containing Small Subunit (SSU) ...
 398-468 5.49e-30

Sas10 C-terminal domain; Sas10 is an Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in the production of the 18S rRNA and assembly of the small ribosomal subunit.


Pssm-ID: 462775 [Multi-domain]  Cd Length: 74  Bit Score: 111.48  E-value: 5.49e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 12746430   398 KRAITYQIAKNRGLTPRRKKIDRNPRVKHREKFRKAKIRRRGQVREVRREEQRYSGELSGIRAGVKKSIKL 468
Cdd:pfam09368   4 KRKITYQIEKNKGLTPHRKKENRNPRVKKRYKYEKAKKKRKSQVRVVREEGGGYGGETTGIKTNVVRSVKL 74
Sas10_Utp3 pfam04000
Sas10/Utp3/C1D family; This family contains Utp3 and LCP5 which are components of the U3 ...
 226-306 2.16e-18

Sas10/Utp3/C1D family; This family contains Utp3 and LCP5 which are components of the U3 ribonucleoprotein complex. It also includes the human C1D protein and Saccharomyces cerevisiae YHR081W (rrp47), an exosome-associated protein required for the 3' processing of stable RNAs, and Sas10 which has been identified as a regulator of chromatin silencing. This family also includes the human protein Neuroguidin an initiation factor 4E (eIF4E) binding protein.


Pssm-ID: 461123  Cd Length: 83  Bit Score: 79.61  E-value: 2.16e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12746430   226 IEDLQAKLTEVKDELEPLLQLVEKGVIPT--GRGSEYLKTKYNLYLNYCANISFYLILKARRVPAHGHPVIERLVTYRNL 303
Cdd:pfam04000   1 LEELKKSLDELEESLEPLLKKVKNPTSKGlsEELPSLLRAKNHLLLAYLINLLFYLLLKLSGVSPKDHPVVKELVRLRVY 80


                  ...
gi 12746430   304 INK 306
Cdd:pfam04000  81 LEK 83
 
Name Accession Description Interval E-value
Sas10 pfam09368
Sas10 C-terminal domain; Sas10 is an Essential subunit of U3-containing Small Subunit (SSU) ...
 398-468 5.49e-30

Sas10 C-terminal domain; Sas10 is an Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in the production of the 18S rRNA and assembly of the small ribosomal subunit.


Pssm-ID: 462775 [Multi-domain]  Cd Length: 74  Bit Score: 111.48  E-value: 5.49e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 12746430   398 KRAITYQIAKNRGLTPRRKKIDRNPRVKHREKFRKAKIRRRGQVREVRREEQRYSGELSGIRAGVKKSIKL 468
Cdd:pfam09368   4 KRKITYQIEKNKGLTPHRKKENRNPRVKKRYKYEKAKKKRKSQVRVVREEGGGYGGETTGIKTNVVRSVKL 74
Sas10_Utp3 pfam04000
Sas10/Utp3/C1D family; This family contains Utp3 and LCP5 which are components of the U3 ...
 226-306 2.16e-18

Sas10/Utp3/C1D family; This family contains Utp3 and LCP5 which are components of the U3 ribonucleoprotein complex. It also includes the human C1D protein and Saccharomyces cerevisiae YHR081W (rrp47), an exosome-associated protein required for the 3' processing of stable RNAs, and Sas10 which has been identified as a regulator of chromatin silencing. This family also includes the human protein Neuroguidin an initiation factor 4E (eIF4E) binding protein.


Pssm-ID: 461123  Cd Length: 83  Bit Score: 79.61  E-value: 2.16e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12746430   226 IEDLQAKLTEVKDELEPLLQLVEKGVIPT--GRGSEYLKTKYNLYLNYCANISFYLILKARRVPAHGHPVIERLVTYRNL 303
Cdd:pfam04000   1 LEELKKSLDELEESLEPLLKKVKNPTSKGlsEELPSLLRAKNHLLLAYLINLLFYLLLKLSGVSPKDHPVVKELVRLRVY 80


                  ...
gi 12746430   304 INK 306
Cdd:pfam04000  81 LEK 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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