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Conserved domains on  [gi|30348958|ref|NP_077231|]
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ADP-ribosylation factor-like protein 2-binding protein isoform 2 [Mus musculus]

Protein Classification

ARL2BP/CFAP36 family protein( domain architecture ID 10568900)

ARL2BP/CFAP36 family protein similar to ADP-ribosylation factor-like protein 2-binding protein (ARL2BP, also called BART) and cilia- and flagella-associated protein 36 (CFAP36, also called BARTL1 or CCDC104)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ARL2_Bind_BART pfam11527
The ARF-like 2 binding protein BART; BART binds specifically to ARL2.GTP with a high affinity ...
 9-123 1.28e-47

The ARF-like 2 binding protein BART; BART binds specifically to ARL2.GTP with a high affinity however it does not bind to ARL2.GDP. It is thought that this specific interaction is due to BART being the first identified ARL2-specific effector. The function is not completely characterized. BART is predominantly cytosolic but can also be found to be associated with mitochondria. BART is also involved in binding to the adenine nucleotide transporter ANT1.


:

Pssm-ID: 463288  Cd Length: 115  Bit Score: 149.66  E-value: 1.28e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30348958     9 EFDAVVGCLEDIIMDDEFQLLQRNFMDKYYQEFEDTEENKLTYTPIFNEYISLVEKYIeEQLLERIpGFNMAAFTTTLQH 88
Cdd:pfam11527   1 EFDWIIGSIEDFLMSPEWQSPINDFMDENCLVFEDEEENKLEYTEIFKEYKELVEKLL-ESLLEEI-GFSMEEFLEALEK 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 30348958    89 --HKDEVAGDIFDMLLTFTDFLAFKEMFLDYRAEKEG 123
Cdd:pfam11527  79 lkNKKELAGDIFEQLLAFTDFLAFKEMMLDYNAELEG 115
 
Name Accession Description Interval E-value
ARL2_Bind_BART pfam11527
The ARF-like 2 binding protein BART; BART binds specifically to ARL2.GTP with a high affinity ...
 9-123 1.28e-47

The ARF-like 2 binding protein BART; BART binds specifically to ARL2.GTP with a high affinity however it does not bind to ARL2.GDP. It is thought that this specific interaction is due to BART being the first identified ARL2-specific effector. The function is not completely characterized. BART is predominantly cytosolic but can also be found to be associated with mitochondria. BART is also involved in binding to the adenine nucleotide transporter ANT1.


Pssm-ID: 463288  Cd Length: 115  Bit Score: 149.66  E-value: 1.28e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30348958     9 EFDAVVGCLEDIIMDDEFQLLQRNFMDKYYQEFEDTEENKLTYTPIFNEYISLVEKYIeEQLLERIpGFNMAAFTTTLQH 88
Cdd:pfam11527   1 EFDWIIGSIEDFLMSPEWQSPINDFMDENCLVFEDEEENKLEYTEIFKEYKELVEKLL-ESLLEEI-GFSMEEFLEALEK 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 30348958    89 --HKDEVAGDIFDMLLTFTDFLAFKEMFLDYRAEKEG 123
Cdd:pfam11527  79 lkNKKELAGDIFEQLLAFTDFLAFKEMMLDYNAELEG 115
 
Name Accession Description Interval E-value
ARL2_Bind_BART pfam11527
The ARF-like 2 binding protein BART; BART binds specifically to ARL2.GTP with a high affinity ...
 9-123 1.28e-47

The ARF-like 2 binding protein BART; BART binds specifically to ARL2.GTP with a high affinity however it does not bind to ARL2.GDP. It is thought that this specific interaction is due to BART being the first identified ARL2-specific effector. The function is not completely characterized. BART is predominantly cytosolic but can also be found to be associated with mitochondria. BART is also involved in binding to the adenine nucleotide transporter ANT1.


Pssm-ID: 463288  Cd Length: 115  Bit Score: 149.66  E-value: 1.28e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30348958     9 EFDAVVGCLEDIIMDDEFQLLQRNFMDKYYQEFEDTEENKLTYTPIFNEYISLVEKYIeEQLLERIpGFNMAAFTTTLQH 88
Cdd:pfam11527   1 EFDWIIGSIEDFLMSPEWQSPINDFMDENCLVFEDEEENKLEYTEIFKEYKELVEKLL-ESLLEEI-GFSMEEFLEALEK 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 30348958    89 --HKDEVAGDIFDMLLTFTDFLAFKEMFLDYRAEKEG 123
Cdd:pfam11527  79 lkNKKELAGDIFEQLLAFTDFLAFKEMMLDYNAELEG 115
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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