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Conserved domains on  [gi|58037425|ref|NP_083648|]
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coiled-coil domain-containing protein 172 isoform 1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
17-203 1.89e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 45.82  E-value: 1.89e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037425     17 AEESRRVMREVRSEITRCRGKIKKATEDLSEEKIKLESKVQQLSEKSFLLELLKTHENALERQlseiISERDTLLQACEA 96
Cdd:TIGR02168  665 SAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQ----ISALRKDLARLEA 740
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037425     97 IKNKTTEEEERFIKEITDFNDnyEITKKRDTLMKEN-----IEMEMADLDSQADVLRREMKSVERNRGQLW-ELQKLKNE 170
Cdd:TIGR02168  741 EVEQLEERIAQLSKELTELEA--EIEELEERLEEAEeelaeAEAEIEELEAQIEQLKEELKALREALDELRaELTLLNEE 818
                          170       180       190
                   ....*....|....*....|....*....|...
gi 58037425    171 LLQELFTLQKKLKVLKDEETEAICITKQLEAEK 203
Cdd:TIGR02168  819 AANLRERLESLERRIAATERRLEDLEEQIEELS 851
 
Name Accession Description Interval E-value
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
17-203 1.89e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 45.82  E-value: 1.89e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037425     17 AEESRRVMREVRSEITRCRGKIKKATEDLSEEKIKLESKVQQLSEKSFLLELLKTHENALERQlseiISERDTLLQACEA 96
Cdd:TIGR02168  665 SAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQ----ISALRKDLARLEA 740
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037425     97 IKNKTTEEEERFIKEITDFNDnyEITKKRDTLMKEN-----IEMEMADLDSQADVLRREMKSVERNRGQLW-ELQKLKNE 170
Cdd:TIGR02168  741 EVEQLEERIAQLSKELTELEA--EIEELEERLEEAEeelaeAEAEIEELEAQIEQLKEELKALREALDELRaELTLLNEE 818
                          170       180       190
                   ....*....|....*....|....*....|...
gi 58037425    171 LLQELFTLQKKLKVLKDEETEAICITKQLEAEK 203
Cdd:TIGR02168  819 AANLRERLESLERRIAATERRLEDLEEQIEELS 851
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
16-209 4.24e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 41.29  E-value: 4.24e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037425  16 QAEESRRVMREVRSEITRCRGKIKKATEDLSEEKIKLESKVQQLSEKSFLLELLKTHENALERQLSEIISERDTLLQACE 95
Cdd:COG4942  21 AAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELE 100
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037425  96 AIKNKTTE-----------EEERFIKEITDFNDNYeitkKRDTLMKENIEmemaDLDSQADVLRREMKSVERNRGQLWEL 164
Cdd:COG4942 101 AQKEELAEllralyrlgrqPPLALLLSPEDFLDAV----RRLQYLKYLAP----ARREQAEELRADLAELAALRAELEAE 172
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 58037425 165 QKLKNELLQELFTLQKKLKVLKDEETEAIcitKQLEAEKTKVRDK 209
Cdd:COG4942 173 RAELEALLAELEEERAALEALKAERQKLL---ARLEKELAELAAE 214
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
14-187 3.15e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 38.89  E-value: 3.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037425   14 EHQAEESRRVMREVRSEITRCRGKIkkatEDLSEEKIKLESKVQQLSEKSFLLELLKTHENALERQLSEIISERDTLLQa 93
Cdd:PRK03918 199 EKELEEVLREINEISSELPELREEL----EKLEKEVKELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKK- 273
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037425   94 ceaiKNKTTEEEERFIKEITDFNDNYEITKK-RDTLMKE--NIEMEMADLDSQADVLRREMKSVERNRGQLWELQKLKNE 170
Cdd:PRK03918 274 ----EIEELEEKVKELKELKEKAEEYIKLSEfYEEYLDElrEIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKE 349
                        170
                 ....*....|....*..
gi 58037425  171 LLQELFTLQKKLKVLKD 187
Cdd:PRK03918 350 LEKRLEELEERHELYEE 366
 
Name Accession Description Interval E-value
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
17-203 1.89e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 45.82  E-value: 1.89e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037425     17 AEESRRVMREVRSEITRCRGKIKKATEDLSEEKIKLESKVQQLSEKSFLLELLKTHENALERQlseiISERDTLLQACEA 96
Cdd:TIGR02168  665 SAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQ----ISALRKDLARLEA 740
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037425     97 IKNKTTEEEERFIKEITDFNDnyEITKKRDTLMKEN-----IEMEMADLDSQADVLRREMKSVERNRGQLW-ELQKLKNE 170
Cdd:TIGR02168  741 EVEQLEERIAQLSKELTELEA--EIEELEERLEEAEeelaeAEAEIEELEAQIEQLKEELKALREALDELRaELTLLNEE 818
                          170       180       190
                   ....*....|....*....|....*....|...
gi 58037425    171 LLQELFTLQKKLKVLKDEETEAICITKQLEAEK 203
Cdd:TIGR02168  819 AANLRERLESLERRIAATERRLEDLEEQIEELS 851
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
16-209 4.24e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 41.29  E-value: 4.24e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037425  16 QAEESRRVMREVRSEITRCRGKIKKATEDLSEEKIKLESKVQQLSEKSFLLELLKTHENALERQLSEIISERDTLLQACE 95
Cdd:COG4942  21 AAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELE 100
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037425  96 AIKNKTTE-----------EEERFIKEITDFNDNYeitkKRDTLMKENIEmemaDLDSQADVLRREMKSVERNRGQLWEL 164
Cdd:COG4942 101 AQKEELAEllralyrlgrqPPLALLLSPEDFLDAV----RRLQYLKYLAP----ARREQAEELRADLAELAALRAELEAE 172
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 58037425 165 QKLKNELLQELFTLQKKLKVLKDEETEAIcitKQLEAEKTKVRDK 209
Cdd:COG4942 173 RAELEALLAELEEERAALEALKAERQKLL---ARLEKELAELAAE 214
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
14-250 9.35e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 40.39  E-value: 9.35e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037425  14 EHQAEESRRVMREVRSEITRCRGKIKKATEDLseEKIKLESKVQQLSEK-SFLLELLktheNALERQLSEIISERDTLLQ 92
Cdd:COG3206 167 ELRREEARKALEFLEEQLPELRKELEEAEAAL--EEFRQKNGLVDLSEEaKLLLQQL----SELESQLAEARAELAEAEA 240
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037425  93 ACEAIKNKTTEEEErfikEITDFNDNYEITKKRDTLmkENIEMEMADLDSQADVLRREMKSVERNRGQLweLQKLKNELL 172
Cdd:COG3206 241 RLAALRAQLGSGPD----ALPELLQSPVIQQLRAQL--AELEAELAELSARYTPNHPDVIALRAQIAAL--RAQLQQEAQ 312
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 58037425 173 QELFTLQKKLKVLKDEETEaicITKQLEAEKTKVRDKPQHDPECVRLKRELDLYkaedmESVYRALQAEVDLLELALA 250
Cdd:COG3206 313 RILASLEAELEALQAREAS---LQAQLAQLEARLAELPELEAELRRLEREVEVA-----RELYESLLQRLEEARLAEA 382
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
14-187 3.15e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 38.89  E-value: 3.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037425   14 EHQAEESRRVMREVRSEITRCRGKIkkatEDLSEEKIKLESKVQQLSEKSFLLELLKTHENALERQLSEIISERDTLLQa 93
Cdd:PRK03918 199 EKELEEVLREINEISSELPELREEL----EKLEKEVKELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKK- 273
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037425   94 ceaiKNKTTEEEERFIKEITDFNDNYEITKK-RDTLMKE--NIEMEMADLDSQADVLRREMKSVERNRGQLWELQKLKNE 170
Cdd:PRK03918 274 ----EIEELEEKVKELKELKEKAEEYIKLSEfYEEYLDElrEIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKE 349
                        170
                 ....*....|....*..
gi 58037425  171 LLQELFTLQKKLKVLKD 187
Cdd:PRK03918 350 LEKRLEELEERHELYEE 366
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
12-175 3.24e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 38.74  E-value: 3.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037425   12 FSEHQAEESRRVMREVRSEITRCRGKIKKATEDLSEEKIKLESKVQQLSEKSF-LLELLKTHENALERQLSEIISERDTL 90
Cdd:COG4913  285 FAQRRLELLEAELEELRAELARLEAELERLEARLDALREELDELEAQIRGNGGdRLEQLEREIERLERELEERERRRARL 364
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037425   91 LQACEAIKNKTTEEEERF---IKEITDFNDNYEITKKRDTLMKENIEMEMADLDSQADVLRREMKSVERNRGQL-WELQK 166
Cdd:COG4913  365 EALLAALGLPLPASAEEFaalRAEAAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNIpARLLA 444

                 ....*....
gi 58037425  167 LKNELLQEL 175
Cdd:COG4913  445 LRDALAEAL 453
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
41-259 3.66e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 38.21  E-value: 3.66e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037425  41 ATEDLSEEKIKLESKVQQLSEKSFLLELLKTHENALERQLSEI---ISERDTLLQACEAIKNKTTEEEERFIKEITDFND 117
Cdd:COG4942  18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALerrIAALARRIRALEQELAALEAELAELEKEIAELRA 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037425 118 NYEITKKR-----DTLMKENIEMEMADLDSQADVLRREMKS------VERNRGQLWELQKLKNELLQELFTLQKKLKVLK 186
Cdd:COG4942  98 ELEAQKEElaellRALYRLGRQPPLALLLSPEDFLDAVRRLqylkylAPARREQAEELRADLAELAALRAELEAERAELE 177
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 58037425 187 DEETEAICITKQLEAEKTKVRDKPQhdpecvRLKRELDLYKAE--DMESVYRALQAEVDLLELALAPKDPQDSNS 259
Cdd:COG4942 178 ALLAELEEERAALEALKAERQKLLA------RLEKELAELAAElaELQQEAEELEALIARLEAEAAAAAERTPAA 246
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
15-208 8.41e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 37.61  E-value: 8.41e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037425  15 HQAEESRRVMREVRSEITRCRGKIKKATEDLSEEKIKLESKVQQLSEKSFLLELLKTHENALERQLSEIISERDTLLQAC 94
Cdd:COG1196 232 LKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERR 311
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037425  95 EAIKNKTTEEEERfIKEITDFNDNYEITKKRDTLMKENIEMEMADLDSQADVLRREMKSVERNRGqlwELQKLKNELLQE 174
Cdd:COG1196 312 RELEERLEELEEE-LAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELA---EAEEELEELAEE 387
                       170       180       190
                ....*....|....*....|....*....|....
gi 58037425 175 LFTLQKKLKVLKDEETEAICITKQLEAEKTKVRD 208
Cdd:COG1196 388 LLEALRAAAELAAQLEELEEAEEALLERLERLEE 421
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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