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Concise Results
Standard Results
Full Results
insulin-degrading enzyme [Mus musculus]
Protein Classification
M16 family metallopeptidase ( domain architecture ID 1000463 )
M16 family metallopeptidase is a zinc-dependent protease, similar to insulin-degrading enzyme (insulinase)
List of domain hits
Name
Accession
Description
Interval
E-value
Ptr super family
cl34066 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, ...
45-1006
0e+00
Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones];
COG1025 :Pssm-ID: 440648 [Multi-domain]
Cd Length: 956
Bit Score: 917.70
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 45 PAI Q RIEDQ I V KSP E D K R E YR GLE L A NG I KVLL I SDP TT DKS S AAL D V HI GS LS DP PNIP GL S HF C EHMLFLGTKKYP KE 124
Cdd:COG1025 26 QGW Q PLAET I I KSP N D P R Q YR AIT L D NG L KVLL V SDP QA DKS A AAL A V PV GS FD DP DDQQ GL A HF L EHMLFLGTKKYP EP 105
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 125 N EY SQ F L S E H A GS S NA F T SG E H TNYYF D V SHEH LE G ALDRFA Q FF LC PLFD ASCK DRE V NAV DS E HEKNVMN D AW R LF Q L 204
Cdd:COG1025 106 G EY QE F I S K H G GS H NA S T AT E R TNYYF E V ENDA LE E ALDRFA D FF AA PLFD PEYV DRE R NAV NA E YTLKRSD D GR R IY Q V 185
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 205 E K A T G NP K HPFS K F GT GN KY TL ETR P NQE gid V R E ELL K F HST YYS S NLM AICVLGRE SLD D L TN L VVKL F SEVE N K N VP 284
Cdd:COG1025 186 H K E T L NP A HPFS R F SV GN LE TL SDK P GSK --- L R D ELL A F YQR YYS A NLM KLVLYSNQ SLD E L EK L ARQT F GAIP N R N LS 262
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 285 L P EFPEHPFQE E H L RQLYK IVP I K DI R N L YVT FPIP DL Q Q YY K S N P GH Y LGH L I G H EG P GSLL SE LK SK G WVNT L VG G QK 364
Cdd:COG1025 263 V P PITVPLYTP E Q L GIIIH IVP L K PR R Q L RLE FPIP NN Q A YY R S K P LT Y ISY L L G N EG E GSLL DW LK KQ G LAES L SA G GG 342
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 365 EGA R G F MF F I I N V D LT EE GL L H VED II LHM F Q YI QKL R AE G P QEW V F Q E CKD L NAV AFRF KD K E RP RG Y T S KIAGKLHY Y 444
Cdd:COG1025 343 ISG R N F GD F S I S V S LT DK GL A H RDE II AAV F A YI ELI R QQ G I QEW Y F D E QAQ L LEL AFRF QE K T RP MD Y V S WLSDNMLR Y 422
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 445 P LNG VL T A E YL LEE F R P DL I DMV L DK L R PEN V R VAIV S K sf EGK TD R T EQ WY G T Q Y KQEA I PEDIIQ KWQ N A DL N GKFK L 524
Cdd:COG1025 423 P VED VL D A D YL MDG F D P AA I RAR L AQ L T PEN A R IWLI S P -- DVP TD K T AY WY D T P Y SVDP I TQEQLA KWQ Q A SQ N PALS L 500
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 525 P TK N EF IP TN F EILS L E K DAT p Y P A L IK D TAMSK LW FKQ D DK F FL PKA CLNFEFFS P F A YVDPLHCNMAY L YLE LL K D S L 604
Cdd:COG1025 501 P EL N PY IP DD F SLIK L D K ESA - K P E L LV D EPGLR LW YMP D QY F AE PKA DIYLSLRN P Q A VDSARNQVLTR L LDY LL N D A L 579
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 605 NE YA Y A A EL AGLSY D L QNTIY G MY LS VK G YND KQP I LL KKITEKM A T FE IDKK RF EII K EAYM R S L N N FRAEQ P HQHAMY 684
Cdd:COG1025 580 NE LS Y Q A SV AGLSY S L YAHQG G LT LS AS G FTQ KQP K LL EALLDQL A S FE PTEE RF AQA K SQLL R Q L D N AEKAK P YSQLFS 659
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 685 Y L RL L MTEVAWTKD EL KE AL DDV TL PR L K AF IP QLL SR LH I E A L LH GN ITKQA A LGVMQMVEDT L IEHAHTKPLLP sqlv 764
Cdd:COG1025 660 P L SR L LQPPYFERE EL LA AL ESI TL QD L R AF RE QLL QQ LH L E M L VV GN LSEEQ A KQLADSLKKQ L APNGTGEEPRR ---- 735
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 765 ry RE V Q L PDR G WFVYQQRNE v H NNCGIE IYYQ TDMQ S TSENMFLE L FC QIIS EPC FN T LRT K EQLGY I V FS G PRRANGIQ 844
Cdd:COG1025 736 -- QV V D L DKS G SLNLEKACD - H TDSALL IYYQ SGYD S LASMALSS L LG QIIS PWF FN Q LRT E EQLGY V V GA G YMPLGRQP 812
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 845 GL R F II QS - EKP P H YL ES R VEA FL ITM E KAIEDMT EE A F QKHI Q A L AIRR L DKPKK LS A E CAKY W GE I ISQQYNY D - R DN 922
Cdd:COG1025 813 GL G F YV QS p VAS P A YL LE R IDD FL KQF E ERLLALS EE E F AQYK Q G L INQL L EPDQN LS E E AQRL W VD I GNGDFEF D t R EK 892
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 923 I e V A YL K T LT KD D I I R F Y Q E ml AV D AP RRHKVSVHVL aremdscpvvgef PSQN dinl S E A PP L PQPEV I HNMTE F KRG L 1002
Cdd:COG1025 893 L - I A AV K K LT RA D L I D F F Q Q -- AV I AP QGLRLLSQSQ ------------- GTKH ---- S K A DE L KGWKT I TDISA F QKT L 952
....
gi 1818176667 1003 P LFP 1006
Cdd:COG1025 953 P VKE 956
Name
Accession
Description
Interval
E-value
Ptr
COG1025 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, ...
45-1006
0e+00
Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440648 [Multi-domain]
Cd Length: 956
Bit Score: 917.70
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 45 PAI Q RIEDQ I V KSP E D K R E YR GLE L A NG I KVLL I SDP TT DKS S AAL D V HI GS LS DP PNIP GL S HF C EHMLFLGTKKYP KE 124
Cdd:COG1025 26 QGW Q PLAET I I KSP N D P R Q YR AIT L D NG L KVLL V SDP QA DKS A AAL A V PV GS FD DP DDQQ GL A HF L EHMLFLGTKKYP EP 105
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 125 N EY SQ F L S E H A GS S NA F T SG E H TNYYF D V SHEH LE G ALDRFA Q FF LC PLFD ASCK DRE V NAV DS E HEKNVMN D AW R LF Q L 204
Cdd:COG1025 106 G EY QE F I S K H G GS H NA S T AT E R TNYYF E V ENDA LE E ALDRFA D FF AA PLFD PEYV DRE R NAV NA E YTLKRSD D GR R IY Q V 185
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 205 E K A T G NP K HPFS K F GT GN KY TL ETR P NQE gid V R E ELL K F HST YYS S NLM AICVLGRE SLD D L TN L VVKL F SEVE N K N VP 284
Cdd:COG1025 186 H K E T L NP A HPFS R F SV GN LE TL SDK P GSK --- L R D ELL A F YQR YYS A NLM KLVLYSNQ SLD E L EK L ARQT F GAIP N R N LS 262
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 285 L P EFPEHPFQE E H L RQLYK IVP I K DI R N L YVT FPIP DL Q Q YY K S N P GH Y LGH L I G H EG P GSLL SE LK SK G WVNT L VG G QK 364
Cdd:COG1025 263 V P PITVPLYTP E Q L GIIIH IVP L K PR R Q L RLE FPIP NN Q A YY R S K P LT Y ISY L L G N EG E GSLL DW LK KQ G LAES L SA G GG 342
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 365 EGA R G F MF F I I N V D LT EE GL L H VED II LHM F Q YI QKL R AE G P QEW V F Q E CKD L NAV AFRF KD K E RP RG Y T S KIAGKLHY Y 444
Cdd:COG1025 343 ISG R N F GD F S I S V S LT DK GL A H RDE II AAV F A YI ELI R QQ G I QEW Y F D E QAQ L LEL AFRF QE K T RP MD Y V S WLSDNMLR Y 422
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 445 P LNG VL T A E YL LEE F R P DL I DMV L DK L R PEN V R VAIV S K sf EGK TD R T EQ WY G T Q Y KQEA I PEDIIQ KWQ N A DL N GKFK L 524
Cdd:COG1025 423 P VED VL D A D YL MDG F D P AA I RAR L AQ L T PEN A R IWLI S P -- DVP TD K T AY WY D T P Y SVDP I TQEQLA KWQ Q A SQ N PALS L 500
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 525 P TK N EF IP TN F EILS L E K DAT p Y P A L IK D TAMSK LW FKQ D DK F FL PKA CLNFEFFS P F A YVDPLHCNMAY L YLE LL K D S L 604
Cdd:COG1025 501 P EL N PY IP DD F SLIK L D K ESA - K P E L LV D EPGLR LW YMP D QY F AE PKA DIYLSLRN P Q A VDSARNQVLTR L LDY LL N D A L 579
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 605 NE YA Y A A EL AGLSY D L QNTIY G MY LS VK G YND KQP I LL KKITEKM A T FE IDKK RF EII K EAYM R S L N N FRAEQ P HQHAMY 684
Cdd:COG1025 580 NE LS Y Q A SV AGLSY S L YAHQG G LT LS AS G FTQ KQP K LL EALLDQL A S FE PTEE RF AQA K SQLL R Q L D N AEKAK P YSQLFS 659
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 685 Y L RL L MTEVAWTKD EL KE AL DDV TL PR L K AF IP QLL SR LH I E A L LH GN ITKQA A LGVMQMVEDT L IEHAHTKPLLP sqlv 764
Cdd:COG1025 660 P L SR L LQPPYFERE EL LA AL ESI TL QD L R AF RE QLL QQ LH L E M L VV GN LSEEQ A KQLADSLKKQ L APNGTGEEPRR ---- 735
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 765 ry RE V Q L PDR G WFVYQQRNE v H NNCGIE IYYQ TDMQ S TSENMFLE L FC QIIS EPC FN T LRT K EQLGY I V FS G PRRANGIQ 844
Cdd:COG1025 736 -- QV V D L DKS G SLNLEKACD - H TDSALL IYYQ SGYD S LASMALSS L LG QIIS PWF FN Q LRT E EQLGY V V GA G YMPLGRQP 812
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 845 GL R F II QS - EKP P H YL ES R VEA FL ITM E KAIEDMT EE A F QKHI Q A L AIRR L DKPKK LS A E CAKY W GE I ISQQYNY D - R DN 922
Cdd:COG1025 813 GL G F YV QS p VAS P A YL LE R IDD FL KQF E ERLLALS EE E F AQYK Q G L INQL L EPDQN LS E E AQRL W VD I GNGDFEF D t R EK 892
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 923 I e V A YL K T LT KD D I I R F Y Q E ml AV D AP RRHKVSVHVL aremdscpvvgef PSQN dinl S E A PP L PQPEV I HNMTE F KRG L 1002
Cdd:COG1025 893 L - I A AV K K LT RA D L I D F F Q Q -- AV I AP QGLRLLSQSQ ------------- GTKH ---- S K A DE L KGWKT I TDISA F QKT L 952
....
gi 1818176667 1003 P LFP 1006
Cdd:COG1025 953 P VKE 956
PRK15101
PRK15101 protease3; Provisional
41-950
3.82e-145
protease3; Provisional
Pssm-ID: 185056 [Multi-domain]
Cd Length: 961
Bit Score: 457.90
E-value: 3.82e-145
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 41 TMSNPAI Q RIEDQ I V KS PE D K R E Y RGLE L A NG IK VLL I SDP TTD KS S AAL DVHI GSL S DP PNIP GL S H FC EHM LFL G T KK 120
Cdd:PRK15101 21 SQAETGW Q PLQET I R KS EK D P R Q Y QAIR L D NG MT VLL V SDP QAV KS L AAL ALPV GSL E DP DAQQ GL A H YL EHM VLM G S KK 100
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 121 YP KENEYSQ FL SE H A GS S NA F T SGEH T NY Y FD V SHEH L EG A L DR F A QFFLC PL F D ASCK DRE V NAV DS E HEKNVMN D AW R 200
Cdd:PRK15101 101 YP QPDSLAE FL KK H G GS H NA S T ASYR T AF Y LE V ENDA L PP A V DR L A DAIAE PL L D PKNA DRE R NAV NA E LTMARSR D GM R 180
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 201 LF Q LEKA T G NP K HP F S K F GT GN KY TL ETR P NQE gid VREE L LK F HST YYS S NLM AICVLGRES L DD L TN L VVKL F SE V E N 280
Cdd:PRK15101 181 MA Q VSAE T I NP A HP G S R F SG GN LE TL SDK P GSK --- LQDA L VD F YQR YYS A NLM KAVIYSNQP L PE L AK L AADT F GR V P N 257
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 281 KN VPL PE FPEHPFQEEHLRQLYKI VP IKDIRN L Y V T F P I PDLQQYYK S NPGH Y LGH LIG HEG PG S L LSE L KSK G WVNTLV 360
Cdd:PRK15101 258 KN ASV PE ITVPVVTDAQKGIIIHY VP AQPRKV L R V E F R I DNNSAKFR S KTDE Y ISY LIG NRS PG T L SDW L QKQ G LAEGIS 337
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 361 G G QK --- EGAR G fm F F I I N V D LT EE GL LHVEDIILHM F Q Y IQK LR AE G PQEWV F Q E CKDLNAVA FR FKDKE R PRG Y TSKI 437
Cdd:PRK15101 338 A G AD pmv DRNS G -- V F A I S V S LT DK GL AQRDQVVAAI F S Y LNL LR EK G IDKSY F D E LAHVLDLD FR YPSIT R DMD Y IEWL 415
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 438 A GKLHYY P LNGV L T A E Y LLEEFR P DL I DMV L DKLR P E N V R VAIV S K sf EGKTDR T EQWYGTQ Y KQEA I P E DIIQK WQ NAD 517
Cdd:PRK15101 416 A DTMLRV P VEHT L D A P Y IADRYD P KA I KAR L AEMT P Q N A R IWYI S P -- QEPHNK T AYFVDAP Y QVDK I S E QTFAD WQ QKA 493
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 518 L N GKFK LP TK N EF IP TN F EILSLE K d A TPY P A LI K D T ------ A M SKLW F KQD dkffl PKA CLNFEFFS P F A YVDPLHCN 591
Cdd:PRK15101 494 Q N IALS LP EL N PY IP DD F SLIKAD K - A YKH P E LI V D E pglrvv Y M PSQY F ADE ----- PKA DISLVLRN P K A MDSARNQV 567
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 592 MAY L -- YL EL L kd S L NEYAYA A ELA G L S YDL q N TIY G MYLSVK GY NDKQ P I LL KKIT E KMAT F EIDKKRFEII K EA Y MRS 669
Cdd:PRK15101 568 LFA L nd YL AG L -- A L DQLSNQ A SVG G I S FST - N ANN G LMVNAN GY TQRL P Q LL QALL E GYFS F TPTEEQLAQA K SW Y REQ 644
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 670 L NNFRAEQPHQH A MYYLRL L MTEVAWTK DE LKEA L DDV TL PRLK A FIPQ LLS RLHI E A L LH GN I T KQAA lgvmqmve D TL 749
Cdd:PRK15101 645 L DSAEKGKAYEQ A IMPAQM L SQVPYFER DE RRKL L PSI TL KDVL A YRDA LLS GATP E F L VV GN L T EEQV -------- T TL 716
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 750 IEHAHTK - PLLPSQLV R YRE V QLPDRGWFVYQQRNEVHNNCGIEI Y YQ T DMQSTSENMFLE L FC QII SEPCF N T LRT K EQ 828
Cdd:PRK15101 717 ARDVQKQ l GADGTEWW R GKD V VVDKKQSVNFEKAGSSTDSALAAV Y VP T GYDEYQSSAYSS L LG QII QPWFY N Q LRT E EQ 796
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 829 LGY I VF SG P RRANGIQ G LR F II QS - E K P P H YL ES R VE AF LITM E KAIED M TE E A F QKHI QAL AIRR L DK P KK L SA E CAKY 907
Cdd:PRK15101 797 LGY A VF AF P MSVGRQW G MG F LL QS n D K Q P A YL WQ R YQ AF FPQA E AKLRA M KP E E F AQYQ QAL INQL L QA P QT L GE E ASRL 876
890 900 910 920
....*....|....*....|....*....|....*....|....
gi 1818176667 908 WGEIISQQYNY D - RD N I e V A YL K T LT KDDIIR F YQE ml AV DA P R 950
Cdd:PRK15101 877 SKDFDRGNMRF D s RD K I - I A QI K L LT PQKLAD F FHQ -- AV IE P Q 917
Peptidase_M16_M
pfam16187 Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 ...
422-703
6.08e-131
Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 in eukaryotes of the insulin-degrading-enzyme type. Insulin-degrading enzymes - insulysin - are zinc metallopeptidases that metabolize several bioactive peptides, including insulin and the amyloid-beta-peptide. The tertiary structure of insulin-degrading enzymes resembles a clamshell composed of four structurally similar domains arranged to enclose a large central chamber. Substrates must enter the chamber, and it is likely that a hinge-like conformational change allows substrate binding and product release. Triphosphates are found to dock between the inner surfaces of the non-catalytic domains three and four.
Pssm-ID: 465051 [Multi-domain]
Cd Length: 284
Bit Score: 397.32
E-value: 6.08e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 422 FRF KD K ER P RG Y T S KI A GKLHY YP LNGV L TAE YLL E E FR P D LI DMV LD K L R PEN V R VAI VSK S FEG K TD RT E Q WYGT Q Y K 501
Cdd:pfam16187 1 FRF QE K SP P SD Y V S SL A SNMQP YP PEDI L SGD YLL R E YD P E LI QEL LD Y L T PEN A R ITL VSK E FEG E TD QK E P WYGT E Y S 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 502 Q E A IPE DIIQ KW Q NA - DL N GKFK LP TK N E FIPT N F EILSL E - K DATP YP A LI K DT AM S K LW F K Q DD K F FL PKA CLNFEFF 579
Cdd:pfam16187 81 V E P IPE ELLK KW K NA p EP N PELH LP EP N P FIPT D F DLKKK E v K EPAK YP V LI R DT PL S R LW Y K K DD T F WV PKA NIYLSLR 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 580 SP F AY VD P LHCNMAY LY L ELLKDSLNEYAY A AELAGLSY D L QN T IY G MY LSV K GYNDK Q P I LL K KI T EK MAT FEID KK RF 659
Cdd:pfam16187 161 SP L AY SS P RNAVLTR LY V ELLKDSLNEYAY D AELAGLSY S L SA T ER G LT LSV S GYNDK L P V LL E KI L EK LRD FEID PD RF 240
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 1818176667 660 EIIKE AYM RS LN NF RA EQP H Q H A MY YL RL L MT E VA WT KD E LK EA 703
Cdd:pfam16187 241 EIIKE QLL RS YK NF AL EQP Y Q Q A FD YL LY L LE E RS WT PE E KL EA 284
Name
Accession
Description
Interval
E-value
Ptr
COG1025 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, ...
45-1006
0e+00
Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440648 [Multi-domain]
Cd Length: 956
Bit Score: 917.70
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 45 PAI Q RIEDQ I V KSP E D K R E YR GLE L A NG I KVLL I SDP TT DKS S AAL D V HI GS LS DP PNIP GL S HF C EHMLFLGTKKYP KE 124
Cdd:COG1025 26 QGW Q PLAET I I KSP N D P R Q YR AIT L D NG L KVLL V SDP QA DKS A AAL A V PV GS FD DP DDQQ GL A HF L EHMLFLGTKKYP EP 105
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 125 N EY SQ F L S E H A GS S NA F T SG E H TNYYF D V SHEH LE G ALDRFA Q FF LC PLFD ASCK DRE V NAV DS E HEKNVMN D AW R LF Q L 204
Cdd:COG1025 106 G EY QE F I S K H G GS H NA S T AT E R TNYYF E V ENDA LE E ALDRFA D FF AA PLFD PEYV DRE R NAV NA E YTLKRSD D GR R IY Q V 185
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 205 E K A T G NP K HPFS K F GT GN KY TL ETR P NQE gid V R E ELL K F HST YYS S NLM AICVLGRE SLD D L TN L VVKL F SEVE N K N VP 284
Cdd:COG1025 186 H K E T L NP A HPFS R F SV GN LE TL SDK P GSK --- L R D ELL A F YQR YYS A NLM KLVLYSNQ SLD E L EK L ARQT F GAIP N R N LS 262
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 285 L P EFPEHPFQE E H L RQLYK IVP I K DI R N L YVT FPIP DL Q Q YY K S N P GH Y LGH L I G H EG P GSLL SE LK SK G WVNT L VG G QK 364
Cdd:COG1025 263 V P PITVPLYTP E Q L GIIIH IVP L K PR R Q L RLE FPIP NN Q A YY R S K P LT Y ISY L L G N EG E GSLL DW LK KQ G LAES L SA G GG 342
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 365 EGA R G F MF F I I N V D LT EE GL L H VED II LHM F Q YI QKL R AE G P QEW V F Q E CKD L NAV AFRF KD K E RP RG Y T S KIAGKLHY Y 444
Cdd:COG1025 343 ISG R N F GD F S I S V S LT DK GL A H RDE II AAV F A YI ELI R QQ G I QEW Y F D E QAQ L LEL AFRF QE K T RP MD Y V S WLSDNMLR Y 422
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 445 P LNG VL T A E YL LEE F R P DL I DMV L DK L R PEN V R VAIV S K sf EGK TD R T EQ WY G T Q Y KQEA I PEDIIQ KWQ N A DL N GKFK L 524
Cdd:COG1025 423 P VED VL D A D YL MDG F D P AA I RAR L AQ L T PEN A R IWLI S P -- DVP TD K T AY WY D T P Y SVDP I TQEQLA KWQ Q A SQ N PALS L 500
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 525 P TK N EF IP TN F EILS L E K DAT p Y P A L IK D TAMSK LW FKQ D DK F FL PKA CLNFEFFS P F A YVDPLHCNMAY L YLE LL K D S L 604
Cdd:COG1025 501 P EL N PY IP DD F SLIK L D K ESA - K P E L LV D EPGLR LW YMP D QY F AE PKA DIYLSLRN P Q A VDSARNQVLTR L LDY LL N D A L 579
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 605 NE YA Y A A EL AGLSY D L QNTIY G MY LS VK G YND KQP I LL KKITEKM A T FE IDKK RF EII K EAYM R S L N N FRAEQ P HQHAMY 684
Cdd:COG1025 580 NE LS Y Q A SV AGLSY S L YAHQG G LT LS AS G FTQ KQP K LL EALLDQL A S FE PTEE RF AQA K SQLL R Q L D N AEKAK P YSQLFS 659
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 685 Y L RL L MTEVAWTKD EL KE AL DDV TL PR L K AF IP QLL SR LH I E A L LH GN ITKQA A LGVMQMVEDT L IEHAHTKPLLP sqlv 764
Cdd:COG1025 660 P L SR L LQPPYFERE EL LA AL ESI TL QD L R AF RE QLL QQ LH L E M L VV GN LSEEQ A KQLADSLKKQ L APNGTGEEPRR ---- 735
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 765 ry RE V Q L PDR G WFVYQQRNE v H NNCGIE IYYQ TDMQ S TSENMFLE L FC QIIS EPC FN T LRT K EQLGY I V FS G PRRANGIQ 844
Cdd:COG1025 736 -- QV V D L DKS G SLNLEKACD - H TDSALL IYYQ SGYD S LASMALSS L LG QIIS PWF FN Q LRT E EQLGY V V GA G YMPLGRQP 812
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 845 GL R F II QS - EKP P H YL ES R VEA FL ITM E KAIEDMT EE A F QKHI Q A L AIRR L DKPKK LS A E CAKY W GE I ISQQYNY D - R DN 922
Cdd:COG1025 813 GL G F YV QS p VAS P A YL LE R IDD FL KQF E ERLLALS EE E F AQYK Q G L INQL L EPDQN LS E E AQRL W VD I GNGDFEF D t R EK 892
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 923 I e V A YL K T LT KD D I I R F Y Q E ml AV D AP RRHKVSVHVL aremdscpvvgef PSQN dinl S E A PP L PQPEV I HNMTE F KRG L 1002
Cdd:COG1025 893 L - I A AV K K LT RA D L I D F F Q Q -- AV I AP QGLRLLSQSQ ------------- GTKH ---- S K A DE L KGWKT I TDISA F QKT L 952
....
gi 1818176667 1003 P LFP 1006
Cdd:COG1025 953 P VKE 956
PRK15101
PRK15101 protease3; Provisional
41-950
3.82e-145
protease3; Provisional
Pssm-ID: 185056 [Multi-domain]
Cd Length: 961
Bit Score: 457.90
E-value: 3.82e-145
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 41 TMSNPAI Q RIEDQ I V KS PE D K R E Y RGLE L A NG IK VLL I SDP TTD KS S AAL DVHI GSL S DP PNIP GL S H FC EHM LFL G T KK 120
Cdd:PRK15101 21 SQAETGW Q PLQET I R KS EK D P R Q Y QAIR L D NG MT VLL V SDP QAV KS L AAL ALPV GSL E DP DAQQ GL A H YL EHM VLM G S KK 100
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 121 YP KENEYSQ FL SE H A GS S NA F T SGEH T NY Y FD V SHEH L EG A L DR F A QFFLC PL F D ASCK DRE V NAV DS E HEKNVMN D AW R 200
Cdd:PRK15101 101 YP QPDSLAE FL KK H G GS H NA S T ASYR T AF Y LE V ENDA L PP A V DR L A DAIAE PL L D PKNA DRE R NAV NA E LTMARSR D GM R 180
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 201 LF Q LEKA T G NP K HP F S K F GT GN KY TL ETR P NQE gid VREE L LK F HST YYS S NLM AICVLGRES L DD L TN L VVKL F SE V E N 280
Cdd:PRK15101 181 MA Q VSAE T I NP A HP G S R F SG GN LE TL SDK P GSK --- LQDA L VD F YQR YYS A NLM KAVIYSNQP L PE L AK L AADT F GR V P N 257
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 281 KN VPL PE FPEHPFQEEHLRQLYKI VP IKDIRN L Y V T F P I PDLQQYYK S NPGH Y LGH LIG HEG PG S L LSE L KSK G WVNTLV 360
Cdd:PRK15101 258 KN ASV PE ITVPVVTDAQKGIIIHY VP AQPRKV L R V E F R I DNNSAKFR S KTDE Y ISY LIG NRS PG T L SDW L QKQ G LAEGIS 337
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 361 G G QK --- EGAR G fm F F I I N V D LT EE GL LHVEDIILHM F Q Y IQK LR AE G PQEWV F Q E CKDLNAVA FR FKDKE R PRG Y TSKI 437
Cdd:PRK15101 338 A G AD pmv DRNS G -- V F A I S V S LT DK GL AQRDQVVAAI F S Y LNL LR EK G IDKSY F D E LAHVLDLD FR YPSIT R DMD Y IEWL 415
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 438 A GKLHYY P LNGV L T A E Y LLEEFR P DL I DMV L DKLR P E N V R VAIV S K sf EGKTDR T EQWYGTQ Y KQEA I P E DIIQK WQ NAD 517
Cdd:PRK15101 416 A DTMLRV P VEHT L D A P Y IADRYD P KA I KAR L AEMT P Q N A R IWYI S P -- QEPHNK T AYFVDAP Y QVDK I S E QTFAD WQ QKA 493
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 518 L N GKFK LP TK N EF IP TN F EILSLE K d A TPY P A LI K D T ------ A M SKLW F KQD dkffl PKA CLNFEFFS P F A YVDPLHCN 591
Cdd:PRK15101 494 Q N IALS LP EL N PY IP DD F SLIKAD K - A YKH P E LI V D E pglrvv Y M PSQY F ADE ----- PKA DISLVLRN P K A MDSARNQV 567
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 592 MAY L -- YL EL L kd S L NEYAYA A ELA G L S YDL q N TIY G MYLSVK GY NDKQ P I LL KKIT E KMAT F EIDKKRFEII K EA Y MRS 669
Cdd:PRK15101 568 LFA L nd YL AG L -- A L DQLSNQ A SVG G I S FST - N ANN G LMVNAN GY TQRL P Q LL QALL E GYFS F TPTEEQLAQA K SW Y REQ 644
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 670 L NNFRAEQPHQH A MYYLRL L MTEVAWTK DE LKEA L DDV TL PRLK A FIPQ LLS RLHI E A L LH GN I T KQAA lgvmqmve D TL 749
Cdd:PRK15101 645 L DSAEKGKAYEQ A IMPAQM L SQVPYFER DE RRKL L PSI TL KDVL A YRDA LLS GATP E F L VV GN L T EEQV -------- T TL 716
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 750 IEHAHTK - PLLPSQLV R YRE V QLPDRGWFVYQQRNEVHNNCGIEI Y YQ T DMQSTSENMFLE L FC QII SEPCF N T LRT K EQ 828
Cdd:PRK15101 717 ARDVQKQ l GADGTEWW R GKD V VVDKKQSVNFEKAGSSTDSALAAV Y VP T GYDEYQSSAYSS L LG QII QPWFY N Q LRT E EQ 796
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 829 LGY I VF SG P RRANGIQ G LR F II QS - E K P P H YL ES R VE AF LITM E KAIED M TE E A F QKHI QAL AIRR L DK P KK L SA E CAKY 907
Cdd:PRK15101 797 LGY A VF AF P MSVGRQW G MG F LL QS n D K Q P A YL WQ R YQ AF FPQA E AKLRA M KP E E F AQYQ QAL INQL L QA P QT L GE E ASRL 876
890 900 910 920
....*....|....*....|....*....|....*....|....
gi 1818176667 908 WGEIISQQYNY D - RD N I e V A YL K T LT KDDIIR F YQE ml AV DA P R 950
Cdd:PRK15101 877 SKDFDRGNMRF D s RD K I - I A QI K L LT PQKLAD F FHQ -- AV IE P Q 917
Peptidase_M16_M
pfam16187 Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 ...
422-703
6.08e-131
Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 in eukaryotes of the insulin-degrading-enzyme type. Insulin-degrading enzymes - insulysin - are zinc metallopeptidases that metabolize several bioactive peptides, including insulin and the amyloid-beta-peptide. The tertiary structure of insulin-degrading enzymes resembles a clamshell composed of four structurally similar domains arranged to enclose a large central chamber. Substrates must enter the chamber, and it is likely that a hinge-like conformational change allows substrate binding and product release. Triphosphates are found to dock between the inner surfaces of the non-catalytic domains three and four.
Pssm-ID: 465051 [Multi-domain]
Cd Length: 284
Bit Score: 397.32
E-value: 6.08e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 422 FRF KD K ER P RG Y T S KI A GKLHY YP LNGV L TAE YLL E E FR P D LI DMV LD K L R PEN V R VAI VSK S FEG K TD RT E Q WYGT Q Y K 501
Cdd:pfam16187 1 FRF QE K SP P SD Y V S SL A SNMQP YP PEDI L SGD YLL R E YD P E LI QEL LD Y L T PEN A R ITL VSK E FEG E TD QK E P WYGT E Y S 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 502 Q E A IPE DIIQ KW Q NA - DL N GKFK LP TK N E FIPT N F EILSL E - K DATP YP A LI K DT AM S K LW F K Q DD K F FL PKA CLNFEFF 579
Cdd:pfam16187 81 V E P IPE ELLK KW K NA p EP N PELH LP EP N P FIPT D F DLKKK E v K EPAK YP V LI R DT PL S R LW Y K K DD T F WV PKA NIYLSLR 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 580 SP F AY VD P LHCNMAY LY L ELLKDSLNEYAY A AELAGLSY D L QN T IY G MY LSV K GYNDK Q P I LL K KI T EK MAT FEID KK RF 659
Cdd:pfam16187 161 SP L AY SS P RNAVLTR LY V ELLKDSLNEYAY D AELAGLSY S L SA T ER G LT LSV S GYNDK L P V LL E KI L EK LRD FEID PD RF 240
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 1818176667 660 EIIKE AYM RS LN NF RA EQP H Q H A MY YL RL L MT E VA WT KD E LK EA 703
Cdd:pfam16187 241 EIIKE QLL RS YK NF AL EQP Y Q Q A FD YL LY L LE E RS WT PE E KL EA 284
Peptidase_M16
pfam00675 Insulinase (Peptidase family M16);
74-212
1.39e-49
Insulinase (Peptidase family M16);
Pssm-ID: 425812 [Multi-domain]
Cd Length: 149
Bit Score: 172.10
E-value: 1.39e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 74 K V LLI SDP TT D K S SAA L DVHI GS LSD P P N IP GL S HF C EHM L F L GTKKYP k E NE YSQF L SEHA GS S NAFTS G E H T N YY FD V 153
Cdd:pfam00675 1 R V ASE SDP PA D T S TVG L WIDA GS RYE P D N NN GL A HF L EHM A F K GTKKYP - S NE LEEE L EKLG GS L NAFTS R E N T V YY AE V 79
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 154 SHEH L EG A L DR F A Q FF LC PLF DA S CKD R ------- EV N AVDSE HEK ---- N VMND A W R LFQ L EKATGN P K 212
Cdd:pfam00675 80 LNDD L PK A V DR L A D FF RN PLF TE S EIE R erlvvly EV E AVDSE PQL vvle N LHAA A Y R NTP L GRSLLG P G 149
PqqL
COG0612 Predicted Zn-dependent peptidase, M16 family [General function prediction only];
68-477
3.22e-45
Predicted Zn-dependent peptidase, M16 family [General function prediction only];
Pssm-ID: 440377 [Multi-domain]
Cd Length: 427
Bit Score: 168.95
E-value: 3.22e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 68 E L A NG IK V L L IS DP TTDKS S AA L D V HI GS LSD PP NIP GL S HF C EHMLF L GTKK YPK e N E YSQF L SEHA GS S NAFTS GEH T 147
Cdd:COG0612 19 T L P NG LR V I L VP DP EAPVV S VR L W V RV GS RDE PP GKT GL A HF L EHMLF K GTKK RSA - G E IAEE L EALG GS L NAFTS FDY T 97
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 148 N YY FD V SH E H LE G AL DRF A QFF L C P L FD ASCKD RE VNA V DS E HEKNVMNDAWRL F Q -- L EKAT G N pk HP FSKFGT G NKYT 225
Cdd:COG0612 98 V YY LS V LS E D LE L AL ELL A DRL L N P T FD EEELE RE RGV V LE E IRRYEDDPDGLA F E al L AALY G D -- HP YGRPII G TEES 175
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 226 L E T rpnqeg I D v RE E L LK F HST YY SS N LMAIC V L G RESLDDLTN LV V K L F SEVENKNV P LPEF P EH P F Q EEHL R qly KI V 305
Cdd:COG0612 176 I E A ------ I T - RE D L RA F YKR YY RP N NAVLV V V G DVDPEEVLA LV E K Y F GDLPAGPA P PRPD P AE P P Q TGPR R --- VV V 245
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 306 PIK D IR -- NLYVTF P I P DL -- QQ YY KSN pgh Y L GHLI G H e G PG S L L SEL -- KS KG WVNT l VG GQKEGA R GFMF F I I NVDL 379
Cdd:COG0612 246 DDP D AE qa HILLGY P G P AR dd PD YY ALD --- V L NEIL G G - G FS S R L FQE lr EK KG LAYS - VG SSFSPY R DAGL F T I YAGT 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 380 TEEG L LHVEDI IL hmf QYIQK L RA EG PQ E WVFQEC K D -- L NAV A FRFKD kerprgy T S KI A GK L hyyplngvlt AE Y L L E 457
Cdd:COG0612 321 APDK L EEALAA IL --- EELER L AK EG VT E EELERA K N ql L GSL A LSLES ------- N S GL A SQ L ---------- GR Y E L Y 380
410 420
....*....|....*....|...
gi 1818176667 458 EFRP D LIDMV L DKLR --- P E N V R 477
Cdd:COG0612 381 GGDL D YLEEY L ERIE avt A E D V Q 403
Peptidase_M16_C
pfam05193 Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One ...
238-416
4.60e-29
Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One is the active peptidase, whereas the other is inactive. The two domains hold the substrate like a clamp.
Pssm-ID: 428362 [Multi-domain]
Cd Length: 181
Bit Score: 114.80
E-value: 4.60e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 238 RE E L LK F HSTY YS SNL M AICVL G RESLDD L TN L VV K L F SEVENK nv P LPEFPEH P FQEEH L RQLYKI VP I KD IRN -- L YV 315
Cdd:pfam05193 4 RE D L RD F YKKH YS PDN M VLVIV G DVDHEE L LD L AE K Y F GDLPAS -- P KGKPRPP P LEPAK L KGREVV VP K KD EPQ ah L AL 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 316 T FP I P D L QQYYK S NPGHY L GH L I G HEGPGS L LS EL KS K - G WVNTLVGGQKEG a RGFMF F I I NVDLTE E gll H V EDI I LHM 394
Cdd:pfam05193 82 A FP G P P L NNDED S LALDV L NE L L G GGMSSR L FQ EL RE K e G LAYSVSSFNDSY - SDSGL F G I YATVDP E --- N V DEV I ELI 157
170 180
....*....|....*....|..
gi 1818176667 395 FQYIQ KL RA EG PQ E WVFQEC K D 416
Cdd:pfam05193 158 LEELE KL AQ EG VT E EELERA K N 179
Peptidase_M16_C
pfam05193 Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One ...
706-889
7.83e-15
Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One is the active peptidase, whereas the other is inactive. The two domains hold the substrate like a clamp.
Pssm-ID: 428362 [Multi-domain]
Cd Length: 181
Bit Score: 73.58
E-value: 7.83e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 706 DV T LPR L KA F IPQLL S RLHIEALLH G NITKQAA L gvm QMV E DTL ieh AHTKPLLPSQLVRYREVQLPDR G WF V YQQRNEV 785
Cdd:pfam05193 1 SL T RED L RD F YKKHY S PDNMVLVIV G DVDHEEL L --- DLA E KYF --- GDLPASPKGKPRPPPLEPAKLK G RE V VVPKKDE 74
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818176667 786 HNNC g IEIYYQT - DMQSTSENMF L ELFCQIISE ---- PC F NT LR T KE Q L G Y I V F S GPRRAN -- G IQ G LRFIIQS E K pphy 858
Cdd:pfam05193 75 PQAH - LALAFPG p PLNNDEDSLA L DVLNELLGG gmss RL F QE LR E KE G L A Y S V S S FNDSYS ds G LF G IYATVDP E N ---- 149
170 180 190
....*....|....*....|....*....|..
gi 1818176667 859 LESRV E AF L ITM EK - A I E DM TEE AFQKHIQA L 889
Cdd:pfam05193 150 VDEVI E LI L EEL EK l A Q E GV TEE ELERAKNQ L 181
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
