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Conserved domains on  [gi|32566504|ref|NP_502354|]
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uncharacterized protein CELE_ZC518.2 [Caenorhabditis elegans]

Protein Classification

SEC24 family transport protein( domain architecture ID 1001573)

SEC24 family transport protein is a component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5028 super family cl34873
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking ...
 265-982 5.17e-161

Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5028:

Pssm-ID: 227361 [Multi-domain]  Cd Length: 861  Bit Score: 495.47  E-value: 5.17e-161
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504 265 FEDIEIQIPQQ----VANPNAHVDPNIFRSTLAQVPQTEELLKKSRLPFAITLHPFR----DVKNLNIIQTSNIVRCRYC 336
Cdd:COG5028 126 FLPPPPIVPPLttnfVGSEQSNCSPKYVRSTMYAIPETNDLLKKSKIPFGLVIRPFLelypEEDPVPLVEDGSIVRCRRC 205

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504 337 RTYINPYV-YLPDHRHWKCNLCNRNNDLPDDFCWDPV-TKAFGDPRNRPEIQNATVEFIAPSEYMLRPPQPAVYVFVIDI 414
Cdd:COG5028 206 RSYINPFVqFIEQGRKWRCNICRSKNDVPEGFDNPSGpNDPRSDRYSRPELKSGVVDFLAPKEYSLRQPPPPVYVFLIDV 285

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504 415 SAAAIQSGYLHTFAEQLLINIDQMPG-DDRSQVCFIAVDQCLHFFSFSSNKRyPNEMIVDDIDDAFLP-SVTSLLVPMKK 492
Cdd:COG5028 286 SFEAIKNGLVKAAIRAILENLDQIPNfDPRTKIAIICFDSSLHFFKLSPDLD-EQMLIVSDLDEPFLPfPSGLFVLPLKS 364

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504 493 FKDTIRTFIKQLPEFYSQIGPTSngNCLGSALKLAQSMIQEVGGRISIFQVSLPNLGLGALKSREESTEggQNLGPATDF 572
Cdd:COG5028 365 CKQIIETLLDRVPRIFQDNKSPK--NALGPALKAAKSLIGGTGGKIIVFLSTLPNMGIGKLQLREDKES--SLLSCKDSF 440

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504 573 YKALSLECTGSQICLDLFMFNTQYADLATLSEIAKFSTGCVYHFPNYNyRNDIHQVKRFERTLTRYLTRKLGFEAVLRIR 652
Cdd:COG5028 441 YKEFAIECSKVGISVDLFLTSEDYIDVATLSHLCRYTGGQTYFYPNFS-ATRPNDATKLANDLVSHLSMEIGYEAVMRVR 519

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504 653 TSRGLALTGFYGNFFVRSPDLLALANVNPDSALAAQVTLEEKL-PQYVCFQSALLYTSSKGDRRIRVHTMCLPTTGDLLQ 731
Cdd:COG5028 520 CSTGLRVSSFYGNFFNRSSDLCAFSTMPRDTSLLVEFSIDEKLmTSDVYFQVALLYTLNDGERRIRVVNLSLPTSSSIRE 599

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504 732 LYNNFDLKATVSYLAKIGVERSMTgSSLADSREALVNAVVDSVGAYQK-AVSRGSGMLVPRVGHLRLFPSYVLAMLKHPA 810
Cdd:COG5028 600 VYASADQLAIACILAKKASTKALN-SSLKEARVLINKSMVDILKAYKKeLVKSNTSTQLPLPANLKLLPLLMLALLKSSA 678

                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504 811 FSSSRgIRLDERAGAMLMMRFSPLDQILSDIYPRLYRLNEL---ASMPEDQS---PPALPLSFEHISRGGVYLMITGTIA 884
Cdd:COG5028 679 FRSGS-TPSDIRISALNRLTSLPLKQLMRNIYPTLYALHDMpieAGLPDEGLlvlPSPINATSSLLESGGLYLIDTGQKI 757

                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504 885 FVYVASSADPGFLVNVFGTSTYNDIDEYS--LLERDNELSRRVHAFFKQVTQFRFYLGPIITIKEH---SPLRDVFVRRL 959
Cdd:COG5028 758 FLWFGKDAVPSLLQDLFGVDSLSDIPSGKftLPPTGNEFNERVRNIIGELRSVNDDSTLPLVLVRGggdPSLRLWFFSTL 837

                       730       740
                ....*....|....*....|...
gi 32566504 960 VDDRSESTHSYVEFLQHLKREIS 982
Cdd:COG5028 838 VEDKTLNIPSYLDYLQILHEKIK 860
 
Name Accession Description Interval E-value
COG5028 COG5028
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking ...
 265-982 5.17e-161

Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion];


Pssm-ID: 227361 [Multi-domain]  Cd Length: 861  Bit Score: 495.47  E-value: 5.17e-161
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504 265 FEDIEIQIPQQ----VANPNAHVDPNIFRSTLAQVPQTEELLKKSRLPFAITLHPFR----DVKNLNIIQTSNIVRCRYC 336
Cdd:COG5028 126 FLPPPPIVPPLttnfVGSEQSNCSPKYVRSTMYAIPETNDLLKKSKIPFGLVIRPFLelypEEDPVPLVEDGSIVRCRRC 205

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504 337 RTYINPYV-YLPDHRHWKCNLCNRNNDLPDDFCWDPV-TKAFGDPRNRPEIQNATVEFIAPSEYMLRPPQPAVYVFVIDI 414
Cdd:COG5028 206 RSYINPFVqFIEQGRKWRCNICRSKNDVPEGFDNPSGpNDPRSDRYSRPELKSGVVDFLAPKEYSLRQPPPPVYVFLIDV 285

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504 415 SAAAIQSGYLHTFAEQLLINIDQMPG-DDRSQVCFIAVDQCLHFFSFSSNKRyPNEMIVDDIDDAFLP-SVTSLLVPMKK 492
Cdd:COG5028 286 SFEAIKNGLVKAAIRAILENLDQIPNfDPRTKIAIICFDSSLHFFKLSPDLD-EQMLIVSDLDEPFLPfPSGLFVLPLKS 364

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504 493 FKDTIRTFIKQLPEFYSQIGPTSngNCLGSALKLAQSMIQEVGGRISIFQVSLPNLGLGALKSREESTEggQNLGPATDF 572
Cdd:COG5028 365 CKQIIETLLDRVPRIFQDNKSPK--NALGPALKAAKSLIGGTGGKIIVFLSTLPNMGIGKLQLREDKES--SLLSCKDSF 440

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504 573 YKALSLECTGSQICLDLFMFNTQYADLATLSEIAKFSTGCVYHFPNYNyRNDIHQVKRFERTLTRYLTRKLGFEAVLRIR 652
Cdd:COG5028 441 YKEFAIECSKVGISVDLFLTSEDYIDVATLSHLCRYTGGQTYFYPNFS-ATRPNDATKLANDLVSHLSMEIGYEAVMRVR 519

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504 653 TSRGLALTGFYGNFFVRSPDLLALANVNPDSALAAQVTLEEKL-PQYVCFQSALLYTSSKGDRRIRVHTMCLPTTGDLLQ 731
Cdd:COG5028 520 CSTGLRVSSFYGNFFNRSSDLCAFSTMPRDTSLLVEFSIDEKLmTSDVYFQVALLYTLNDGERRIRVVNLSLPTSSSIRE 599

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504 732 LYNNFDLKATVSYLAKIGVERSMTgSSLADSREALVNAVVDSVGAYQK-AVSRGSGMLVPRVGHLRLFPSYVLAMLKHPA 810
Cdd:COG5028 600 VYASADQLAIACILAKKASTKALN-SSLKEARVLINKSMVDILKAYKKeLVKSNTSTQLPLPANLKLLPLLMLALLKSSA 678

                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504 811 FSSSRgIRLDERAGAMLMMRFSPLDQILSDIYPRLYRLNEL---ASMPEDQS---PPALPLSFEHISRGGVYLMITGTIA 884
Cdd:COG5028 679 FRSGS-TPSDIRISALNRLTSLPLKQLMRNIYPTLYALHDMpieAGLPDEGLlvlPSPINATSSLLESGGLYLIDTGQKI 757

                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504 885 FVYVASSADPGFLVNVFGTSTYNDIDEYS--LLERDNELSRRVHAFFKQVTQFRFYLGPIITIKEH---SPLRDVFVRRL 959
Cdd:COG5028 758 FLWFGKDAVPSLLQDLFGVDSLSDIPSGKftLPPTGNEFNERVRNIIGELRSVNDDSTLPLVLVRGggdPSLRLWFFSTL 837

                       730       740
                ....*....|....*....|...
gi 32566504 960 VDDRSESTHSYVEFLQHLKREIS 982
Cdd:COG5028 838 VEDKTLNIPSYLDYLQILHEKIK 860
Sec24-like cd01479
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the ...
 403-643 2.43e-110

Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes of vesicular carriers within the endocytic and the biosynthetic pathways are COP- and clathrin-coated vesicles. Formation of COPII vesicles requires the ordered assembly of the coat built from several cytosolic components GTPase Sar1, complexes of Sec23-Sec24 and Sec13-Sec31. The process is initiated by the conversion of GDP to GTP by the GTPase Sar1 which then recruits the heterodimeric complex of Sec23 and Sec24. This heterodimeric complex generates the pre-budding complex. The final step leading to membrane deformation and budding of COPII-coated vesicles is carried by the heterodimeric complex Sec13-Sec31. The members of this CD belong to the Sec23-like family. Sec 24 is very similar to Sec23. The Sec23 and Sec24 polypeptides fold into five distinct domains: a beta-barrel, a zinc finger, a vWA or trunk, an all helical region and a carboxy Gelsolin domain. The members of this subgroup carry a partial MIDAS motif and have the overall Para-Rossmann type fold that is characteristic of this superfamily.


Pssm-ID: 238756 [Multi-domain]  Cd Length: 244  Bit Score: 340.79  E-value: 2.43e-110
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504 403 PQPAVYVFVIDISAAAIQSGYLHTFAEQLLINIDQMPGDD-RSQVCFIAVDQCLHFFSFSSNKRYPNEMIVDDIDDAFLP 481
Cdd:cd01479   1 PQPAVYVFLIDVSYNAIKSGLLATACEALLSNLDNLPGDDpRTRVGFITFDSTLHFFNLKSSLEQPQMMVVSDLDDPFLP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504 482 SVTSLLVPMKKFKDTIRTFIKQLPEFYSQIGPTsnGNCLGSALKLAQSMIQEVGGRISIFQVSLPNLGLGALKSREE--- 558
Cdd:cd01479  81 LPDGLLVNLKESRQVIEDLLDQIPEMFQDTKET--ESALGPALQAAFLLLKETGGKIIVFQSSLPTLGAGKLKSREDpkl 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504 559 -STEGGQN-LGPATDFYKALSLECTGSQICLDLFMFNTQYADLATLSEIAKFSTGCVYHFPNYnYRNDIHQVKRFERTLT 636
Cdd:cd01479 159 lSTDKEKQlLQPQTDFYKKLALECVKSQISVDLFLFSNQYVDVATLGCLSRLTGGQVYYYPSF-NFSAPNDVEKLVNELA 237


                ....*..
gi 32566504 637 RYLTRKL 643
Cdd:cd01479 238 RYLTRKI 244
Sec23_trunk pfam04811
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum ...
 403-639 4.88e-91

Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface.


Pssm-ID: 398467 [Multi-domain]  Cd Length: 241  Bit Score: 289.54  E-value: 4.88e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504   403 PQPAVYVFVIDISAAAIQSGYLHTFAEQLLINIDQMPGDDRSQVCFIAVDQCLHFFSFSSNKRYPNEMIVDDIDDAFLPS 482
Cdd:pfam04811   1 PQPPVFLFVIDVSYNAIKSGLLAALKESLLQSLDLLPGDPRARVGFITFDSTVHFFNLGSSLRQPQMLVVSDLQDMFLPL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504   483 VTSLLVPMKKFKDTIRTFIKQLPEFYSQigPTSNGNCLGSALKLAQSMIQ--EVGGRISIFQVSLPNLGL-GALKSREES 559
Cdd:pfam04811  81 PDRFLVPLSECRFVLEDLLEQLPPMFPV--TKRPERCLGPALQAAFLLLKaaFTGGKIMVFQGGLPTVGPgGKLKSRLDE 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504   560 TEGG-----QNLGPATD-FYKALSLECTGSQICLDLFMFNTQYADLATLSEIAKFSTGCVYHFPNYNYRNDihqVKRFER 633
Cdd:pfam04811 159 SHHGtdkekAKLVKKADkFYKSLAKECVKQGHSVDLFAFSLDYVDVATLGQLSRLTGGQVYLYPSFQADVD---GSKFKQ 235


                  ....*.
gi 32566504   634 TLTRYL 639
Cdd:pfam04811 236 DLQRYF 241
PTZ00395 PTZ00395
Sec24-related protein; Provisional
 396-974 8.41e-35

Sec24-related protein; Provisional


Pssm-ID: 185594 [Multi-domain]  Cd Length: 1560  Bit Score: 144.45  E-value: 8.41e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504   396 SEYMLRPPQ-----PAVYVFVIDISAAAIQSGYLHTFAEQLLINIDQMPGDdRSQVCFIAVDQCLHFFSFSSNKRYPNE- 469
Cdd:PTZ00395  938 NSFLAKYPQvknmlPPYFVFVVECSYNAIYNNITYTILEGIRYAVQNVKCP-QTKIAIITFNSSIYFYHCKGGKGVSGEe 1016

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504   470 ------------MIVDDIDDAFLP-SVTSLLVPMKKFKDTIRTFIKQLPEFYSQIgpTSNGNCLGSALKLAQSMIQEVGG 536
Cdd:PTZ00395 1017 gdggggsgnhqvIVMSDVDDPFLPlPLEDLFFGCVEEIDKINTLIDTIKSVSTTM--QSYGSCGNSALKIAMDMLKERNG 1094

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504   537 --RISIFQVSLPNLGLGALKS-----REESTEGGQNLgpatdFYKALSLECTGSQICLDLFMFNTQYADLA--TLSEIAK 607
Cdd:PTZ00395 1095 lgSICMFYTTTPNCGIGAIKElkkdlQENFLEVKQKI-----FYDSLLLDLYAFNISVDIFIISSNNVRVCvpSLQYVAQ 1169

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504   608 FSTGCVYHFPNYNYRNDIHQVkrFERTLTRYLTRKLGFEAVLRIRTSRGLALTGFY---GNF-FVRSPDLLALANVNPDS 683
Cdd:PTZ00395 1170 NTGGKILFVENFLWQKDYKEI--YMNIMDTLTSEDIAYCCELKLRYSHHMSVKKLFccnNNFnSIISVDTIKIPKIRHDQ 1247

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504   684 ALAAQVTLEE--KLPQYVCFQSALLYTSSKGDRRIRVHTMCLPTTGDLLQLYNNFDLKATVSYLAKigverSMTGSSLAD 761
Cdd:PTZ00395 1248 TFAFLLNYSDisESKKQIYFQCACIYTNLWGDRFVRLHTTHMNLTSSLSTVFRYTDAEALMNILIK-----QLCTNILHN 1322

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504   762 SREALVnaVVDSVGA------YQKAVSRGSGMLV-PRVghLRLFPSYVLAMLKHPAfsSSRGIRLDERAGAMLMMRFSPL 834
Cdd:PTZ00395 1323 DNYSKI--IIDNLAAilfsyrINCASSAHSGQLIlPDT--LKLLPLFTSSLLKHNV--TKKEILHDLKVYSLIKLLSMPI 1396

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504   835 DQILSDIYPRLY------RLNELASMPEDQS---PPALPLSFEHISRGGVYLMITGTIAFVYVASSADPGFLVNVFG-TS 904
Cdd:PTZ00395 1397 ISSLLYVYPVMYvihikgKTNEIDSMDVDDDlfiPKTIPSSAEKIYSNGIYLLDACTHFYLYFGFHSDANFAKEIVGdIP 1476

                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 32566504   905 TYNDIDEYSLLERDNelSRRVHAFFKQVTQ---FRFYLgPIITIKEHSPLRDVFVRRLVDDRSESTHSYVEFL 974
Cdd:PTZ00395 1477 TEKNAHELNLTDTPN--AQKVQRIIKNLSRihhFNKYV-PLVMVAPKSNEEEHLISLCVEDKADKEYSYVNFL 1546
 
Name Accession Description Interval E-value
COG5028 COG5028
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking ...
 265-982 5.17e-161

Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion];


Pssm-ID: 227361 [Multi-domain]  Cd Length: 861  Bit Score: 495.47  E-value: 5.17e-161
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504 265 FEDIEIQIPQQ----VANPNAHVDPNIFRSTLAQVPQTEELLKKSRLPFAITLHPFR----DVKNLNIIQTSNIVRCRYC 336
Cdd:COG5028 126 FLPPPPIVPPLttnfVGSEQSNCSPKYVRSTMYAIPETNDLLKKSKIPFGLVIRPFLelypEEDPVPLVEDGSIVRCRRC 205

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504 337 RTYINPYV-YLPDHRHWKCNLCNRNNDLPDDFCWDPV-TKAFGDPRNRPEIQNATVEFIAPSEYMLRPPQPAVYVFVIDI 414
Cdd:COG5028 206 RSYINPFVqFIEQGRKWRCNICRSKNDVPEGFDNPSGpNDPRSDRYSRPELKSGVVDFLAPKEYSLRQPPPPVYVFLIDV 285

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504 415 SAAAIQSGYLHTFAEQLLINIDQMPG-DDRSQVCFIAVDQCLHFFSFSSNKRyPNEMIVDDIDDAFLP-SVTSLLVPMKK 492
Cdd:COG5028 286 SFEAIKNGLVKAAIRAILENLDQIPNfDPRTKIAIICFDSSLHFFKLSPDLD-EQMLIVSDLDEPFLPfPSGLFVLPLKS 364

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504 493 FKDTIRTFIKQLPEFYSQIGPTSngNCLGSALKLAQSMIQEVGGRISIFQVSLPNLGLGALKSREESTEggQNLGPATDF 572
Cdd:COG5028 365 CKQIIETLLDRVPRIFQDNKSPK--NALGPALKAAKSLIGGTGGKIIVFLSTLPNMGIGKLQLREDKES--SLLSCKDSF 440

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504 573 YKALSLECTGSQICLDLFMFNTQYADLATLSEIAKFSTGCVYHFPNYNyRNDIHQVKRFERTLTRYLTRKLGFEAVLRIR 652
Cdd:COG5028 441 YKEFAIECSKVGISVDLFLTSEDYIDVATLSHLCRYTGGQTYFYPNFS-ATRPNDATKLANDLVSHLSMEIGYEAVMRVR 519

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504 653 TSRGLALTGFYGNFFVRSPDLLALANVNPDSALAAQVTLEEKL-PQYVCFQSALLYTSSKGDRRIRVHTMCLPTTGDLLQ 731
Cdd:COG5028 520 CSTGLRVSSFYGNFFNRSSDLCAFSTMPRDTSLLVEFSIDEKLmTSDVYFQVALLYTLNDGERRIRVVNLSLPTSSSIRE 599

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504 732 LYNNFDLKATVSYLAKIGVERSMTgSSLADSREALVNAVVDSVGAYQK-AVSRGSGMLVPRVGHLRLFPSYVLAMLKHPA 810
Cdd:COG5028 600 VYASADQLAIACILAKKASTKALN-SSLKEARVLINKSMVDILKAYKKeLVKSNTSTQLPLPANLKLLPLLMLALLKSSA 678

                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504 811 FSSSRgIRLDERAGAMLMMRFSPLDQILSDIYPRLYRLNEL---ASMPEDQS---PPALPLSFEHISRGGVYLMITGTIA 884
Cdd:COG5028 679 FRSGS-TPSDIRISALNRLTSLPLKQLMRNIYPTLYALHDMpieAGLPDEGLlvlPSPINATSSLLESGGLYLIDTGQKI 757

                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504 885 FVYVASSADPGFLVNVFGTSTYNDIDEYS--LLERDNELSRRVHAFFKQVTQFRFYLGPIITIKEH---SPLRDVFVRRL 959
Cdd:COG5028 758 FLWFGKDAVPSLLQDLFGVDSLSDIPSGKftLPPTGNEFNERVRNIIGELRSVNDDSTLPLVLVRGggdPSLRLWFFSTL 837

                       730       740
                ....*....|....*....|...
gi 32566504 960 VDDRSESTHSYVEFLQHLKREIS 982
Cdd:COG5028 838 VEDKTLNIPSYLDYLQILHEKIK 860
Sec24-like cd01479
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the ...
 403-643 2.43e-110

Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes of vesicular carriers within the endocytic and the biosynthetic pathways are COP- and clathrin-coated vesicles. Formation of COPII vesicles requires the ordered assembly of the coat built from several cytosolic components GTPase Sar1, complexes of Sec23-Sec24 and Sec13-Sec31. The process is initiated by the conversion of GDP to GTP by the GTPase Sar1 which then recruits the heterodimeric complex of Sec23 and Sec24. This heterodimeric complex generates the pre-budding complex. The final step leading to membrane deformation and budding of COPII-coated vesicles is carried by the heterodimeric complex Sec13-Sec31. The members of this CD belong to the Sec23-like family. Sec 24 is very similar to Sec23. The Sec23 and Sec24 polypeptides fold into five distinct domains: a beta-barrel, a zinc finger, a vWA or trunk, an all helical region and a carboxy Gelsolin domain. The members of this subgroup carry a partial MIDAS motif and have the overall Para-Rossmann type fold that is characteristic of this superfamily.


Pssm-ID: 238756 [Multi-domain]  Cd Length: 244  Bit Score: 340.79  E-value: 2.43e-110
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504 403 PQPAVYVFVIDISAAAIQSGYLHTFAEQLLINIDQMPGDD-RSQVCFIAVDQCLHFFSFSSNKRYPNEMIVDDIDDAFLP 481
Cdd:cd01479   1 PQPAVYVFLIDVSYNAIKSGLLATACEALLSNLDNLPGDDpRTRVGFITFDSTLHFFNLKSSLEQPQMMVVSDLDDPFLP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504 482 SVTSLLVPMKKFKDTIRTFIKQLPEFYSQIGPTsnGNCLGSALKLAQSMIQEVGGRISIFQVSLPNLGLGALKSREE--- 558
Cdd:cd01479  81 LPDGLLVNLKESRQVIEDLLDQIPEMFQDTKET--ESALGPALQAAFLLLKETGGKIIVFQSSLPTLGAGKLKSREDpkl 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504 559 -STEGGQN-LGPATDFYKALSLECTGSQICLDLFMFNTQYADLATLSEIAKFSTGCVYHFPNYnYRNDIHQVKRFERTLT 636
Cdd:cd01479 159 lSTDKEKQlLQPQTDFYKKLALECVKSQISVDLFLFSNQYVDVATLGCLSRLTGGQVYYYPSF-NFSAPNDVEKLVNELA 237


                ....*..
gi 32566504 637 RYLTRKL 643
Cdd:cd01479 238 RYLTRKI 244
Sec23_trunk pfam04811
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum ...
 403-639 4.88e-91

Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface.


Pssm-ID: 398467 [Multi-domain]  Cd Length: 241  Bit Score: 289.54  E-value: 4.88e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504   403 PQPAVYVFVIDISAAAIQSGYLHTFAEQLLINIDQMPGDDRSQVCFIAVDQCLHFFSFSSNKRYPNEMIVDDIDDAFLPS 482
Cdd:pfam04811   1 PQPPVFLFVIDVSYNAIKSGLLAALKESLLQSLDLLPGDPRARVGFITFDSTVHFFNLGSSLRQPQMLVVSDLQDMFLPL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504   483 VTSLLVPMKKFKDTIRTFIKQLPEFYSQigPTSNGNCLGSALKLAQSMIQ--EVGGRISIFQVSLPNLGL-GALKSREES 559
Cdd:pfam04811  81 PDRFLVPLSECRFVLEDLLEQLPPMFPV--TKRPERCLGPALQAAFLLLKaaFTGGKIMVFQGGLPTVGPgGKLKSRLDE 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504   560 TEGG-----QNLGPATD-FYKALSLECTGSQICLDLFMFNTQYADLATLSEIAKFSTGCVYHFPNYNYRNDihqVKRFER 633
Cdd:pfam04811 159 SHHGtdkekAKLVKKADkFYKSLAKECVKQGHSVDLFAFSLDYVDVATLGQLSRLTGGQVYLYPSFQADVD---GSKFKQ 235


                  ....*.
gi 32566504   634 TLTRYL 639
Cdd:pfam04811 236 DLQRYF 241
trunk_domain cd01468
trunk domain. COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi ...
 403-637 1.12e-90

trunk domain. COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface. Some members of this family possess a partial MIDAS motif that is a characteristic feature of most vWA domain proteins.


Pssm-ID: 238745 [Multi-domain]  Cd Length: 239  Bit Score: 288.76  E-value: 1.12e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504 403 PQPAVYVFVIDISAAAIQSGYLHTFAEQLLINIDQMPGDDRSQVCFIAVDQCLHFFSFSSNKRYPNEMIVDDIDDAFLPS 482
Cdd:cd01468   1 PQPPVFVFVIDVSYEAIKEGLLQALKESLLASLDLLPGDPRARVGLITYDSTVHFYNLSSDLAQPKMYVVSDLKDVFLPL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504 483 VTSLLVPMKKFKDTIRTFIKQLPEFYSQIGPTSNGNCLGSALKLAQSMIQEV--GGRISIFQVSLPNLGLGALKSREE-- 558
Cdd:cd01468  81 PDRFLVPLSECKKVIHDLLEQLPPMFWPVPTHRPERCLGPALQAAFLLLKGTfaGGRIIVFQGGLPTVGPGKLKSREDke 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504 559 ---STEGGQNLGPATDFYKALSLECTGSQICLDLFMFNTQYADLATLSEIAKFSTGCVYHFPNYNYRNDihqVKRFERTL 635
Cdd:cd01468 161 pirSHDEAQLLKPATKFYKSLAKECVKSGICVDLFAFSLDYVDVATLKQLAKSTGGQVYLYDSFQAPND---GSKFKQDL 237


                ..
gi 32566504 636 TR 637
Cdd:cd01468 238 QR 239
PTZ00395 PTZ00395
Sec24-related protein; Provisional
 396-974 8.41e-35

Sec24-related protein; Provisional


Pssm-ID: 185594 [Multi-domain]  Cd Length: 1560  Bit Score: 144.45  E-value: 8.41e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504   396 SEYMLRPPQ-----PAVYVFVIDISAAAIQSGYLHTFAEQLLINIDQMPGDdRSQVCFIAVDQCLHFFSFSSNKRYPNE- 469
Cdd:PTZ00395  938 NSFLAKYPQvknmlPPYFVFVVECSYNAIYNNITYTILEGIRYAVQNVKCP-QTKIAIITFNSSIYFYHCKGGKGVSGEe 1016

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504   470 ------------MIVDDIDDAFLP-SVTSLLVPMKKFKDTIRTFIKQLPEFYSQIgpTSNGNCLGSALKLAQSMIQEVGG 536
Cdd:PTZ00395 1017 gdggggsgnhqvIVMSDVDDPFLPlPLEDLFFGCVEEIDKINTLIDTIKSVSTTM--QSYGSCGNSALKIAMDMLKERNG 1094

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504   537 --RISIFQVSLPNLGLGALKS-----REESTEGGQNLgpatdFYKALSLECTGSQICLDLFMFNTQYADLA--TLSEIAK 607
Cdd:PTZ00395 1095 lgSICMFYTTTPNCGIGAIKElkkdlQENFLEVKQKI-----FYDSLLLDLYAFNISVDIFIISSNNVRVCvpSLQYVAQ 1169

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504   608 FSTGCVYHFPNYNYRNDIHQVkrFERTLTRYLTRKLGFEAVLRIRTSRGLALTGFY---GNF-FVRSPDLLALANVNPDS 683
Cdd:PTZ00395 1170 NTGGKILFVENFLWQKDYKEI--YMNIMDTLTSEDIAYCCELKLRYSHHMSVKKLFccnNNFnSIISVDTIKIPKIRHDQ 1247

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504   684 ALAAQVTLEE--KLPQYVCFQSALLYTSSKGDRRIRVHTMCLPTTGDLLQLYNNFDLKATVSYLAKigverSMTGSSLAD 761
Cdd:PTZ00395 1248 TFAFLLNYSDisESKKQIYFQCACIYTNLWGDRFVRLHTTHMNLTSSLSTVFRYTDAEALMNILIK-----QLCTNILHN 1322

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504   762 SREALVnaVVDSVGA------YQKAVSRGSGMLV-PRVghLRLFPSYVLAMLKHPAfsSSRGIRLDERAGAMLMMRFSPL 834
Cdd:PTZ00395 1323 DNYSKI--IIDNLAAilfsyrINCASSAHSGQLIlPDT--LKLLPLFTSSLLKHNV--TKKEILHDLKVYSLIKLLSMPI 1396

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504   835 DQILSDIYPRLY------RLNELASMPEDQS---PPALPLSFEHISRGGVYLMITGTIAFVYVASSADPGFLVNVFG-TS 904
Cdd:PTZ00395 1397 ISSLLYVYPVMYvihikgKTNEIDSMDVDDDlfiPKTIPSSAEKIYSNGIYLLDACTHFYLYFGFHSDANFAKEIVGdIP 1476

                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 32566504   905 TYNDIDEYSLLERDNelSRRVHAFFKQVTQ---FRFYLgPIITIKEHSPLRDVFVRRLVDDRSESTHSYVEFL 974
Cdd:PTZ00395 1477 TEKNAHELNLTDTPN--AQKVQRIIKNLSRihhFNKYV-PLVMVAPKSNEEEHLISLCVEDKADKEYSYVNFL 1546
Sec23_BS pfam08033
Sec23/Sec24 beta-sandwich domain;
644-726 1.64e-29

Sec23/Sec24 beta-sandwich domain;


Pssm-ID: 429794 [Multi-domain]  Cd Length: 86  Bit Score: 112.25  E-value: 1.64e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504   644 GFEAVLRIRTSRGLALTGFYGNFFVRS-PDLLALANVNPDSALAAQVTLEEKLP--QYVCFQSALLYTSSKGDRRIRVHT 720
Cdd:pfam08033   1 GFNAVLRVRTSKGLKVSGFIGNFVSRSsGDTWKLPSLDPDTSYAFEFDIDEPLPngSNAYIQFALLYTHSSGERRIRVTT 80


                  ....*.
gi 32566504   721 MCLPTT 726
Cdd:pfam08033  81 VALPVT 86
Sec23_helical pfam04815
Sec23/Sec24 helical domain; COPII-coated vesicles carry proteins from the endoplasmic ...
 737-838 7.39e-21

Sec23/Sec24 helical domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is composed of five alpha helices.


Pssm-ID: 461441 [Multi-domain]  Cd Length: 103  Bit Score: 88.33  E-value: 7.39e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504   737 DLKATVSYLAKIGVERSMTgSSLADSREALVNAVVDSVGAYQKAVSRGSG---MLVPRvgHLRLFPSYVLAMLKHPAFSS 813
Cdd:pfam04815   1 DQEAIAVLLAKKAVEKALS-SSLSDAREALDNKLVDILAAYRKYCASSSSpgqLILPE--SLKLLPLYMLALLKSPALRG 77

                          90       100
                  ....*....|....*....|....*
gi 32566504   814 SRGIRLDERAGAMLMMRFSPLDQIL 838
Cdd:pfam04815  78 GNSSPSDERAYARHLLLSLPVEELL 102
SEC23 COG5047
Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion];
265-755 3.49e-16

Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion];


Pssm-ID: 227380 [Multi-domain]  Cd Length: 755  Bit Score: 83.39  E-value: 3.49e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504 265 FEDIEiqipqqvanpnahvDPNIFRSTLAQVPQTEELLKKSRLPFAITLHPFRDVKNLNIIQTSNIVRCRYCRTYINPYV 344
Cdd:COG5047   3 FEIIE--------------ENDGIRLTWNVFPATRGDATRTVIPIACLYTPLHEDDALTVNYYEPVKCTAPCKAVLNPYC 68

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504 345 YL-PDHRHWKCNLCNRNNDLPddfcwdPVTKAFGDPRNRPEI--QNATVEFIAPseymlRPPQ-PAVYVFVIDIsaaaIQ 420
Cdd:COG5047  69 HIdERNQSWICPFCNQRNTLP------PQYRDISNANLPLELlpQSSTIEYTLS-----KPVIlPPVFFFVVDA----CC 133

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504 421 SGYLHTF-AEQLLINIDQMPGDDRS---------QVCFIAVDQCLHFFSFSSNKRYPNEMIVD---------------DI 475
Cdd:COG5047 134 DEEELTAlKDSLIVSLSLLPPEALVglitygtsiQVHELNAENHRRSYVFSGNKEYTKENLQEllalskptksggfesKI 213

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504 476 DDAFLPSVTSLLVPMKKFKDTIRTFIKQL-PEFYSQIGPTSNGNCLGSALKLAQSMIQEV----GGRISIFQVSLPNLGL 550
Cdd:COG5047 214 SGIGQFASSRFLLPTQQCEFKLLNILEQLqPDPWPVPAGKRPLRCTGSALNIASSLLEQCfpnaGCHIVLFAGGPCTVGP 293

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504 551 GALKSRE----------ESTEGGQNLGPATDFYKALSLECTGSQICLDLFMFNTQYADLATLSEIAKFSTGCVYHFPNYN 620
Cdd:COG5047 294 GTVVSTElkepmrshhdIESDSAQHSKKATKFYKGLAERVANQGHALDIFAGCLDQIGIMEMEPLTTSTGGALVLSDSFT 373

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504 621 yrndihqVKRFERTLTRYLTR------KLGFEAVLRIRTSRGLALTGFYGN---------------FFVRSPDLLALANV 679
Cdd:COG5047 374 -------TSIFKQSFQRIFNRdsegylKMGFNANMEVKTSKNLKIKGLIGHavsvkkkannisdseIGIGATNSWKMASL 446

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504 680 NPDS--ALAAQVTLEEKLPQ-------YVCFQSalLYTSSKGDRRIRVHTMC-LPTTGDLLQLYNNFDLKATVSYLAKIG 749
Cdd:COG5047 447 SPKSnyALYFEIALGAASGSaqrpaeaYIQFIT--TYQHSSGTYRIRVTTVArMFTDGGLPKINRSFDQEAAAVFMARIA 524


                ....*.
gi 32566504 750 VERSMT 755
Cdd:COG5047 525 AFKAET 530
zf-Sec23_Sec24 pfam04810
Sec23/Sec24 zinc finger; COPII-coated vesicles carry proteins from the endoplasmic reticulum ...
 330-366 6.60e-13

Sec23/Sec24 zinc finger; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is found to be zinc binding domain.


Pssm-ID: 461437 [Multi-domain]  Cd Length: 38  Bit Score: 63.62  E-value: 6.60e-13
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 32566504   330 IVRCRYCRTYINPYV-YLPDHRHWKCNLCNRNNDLPDD 366
Cdd:pfam04810   1 PVRCRRCRAYLNPFCqFDFGGKKWTCNFCGTRNPVPPE 38
PLN00162 PLN00162
transport protein sec23; Provisional
 304-590 2.45e-08

transport protein sec23; Provisional


Pssm-ID: 215083 [Multi-domain]  Cd Length: 761  Bit Score: 58.03  E-value: 2.45e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504  304 KSRLPFAITLHPFRDVKNLNIIQTSNIvRCRYCRTYINPYVYLpDH--RHWKCNLCNRNNDLPddfcwdPVTKAFGDpRN 381
Cdd:PLN00162  28 KCVIPLAALYTPLKPLPELPVLPYDPL-RCRTCRAVLNPYCRV-DFqaKIWICPFCFQRNHFP------PHYSSISE-TN 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504  382 RP-EI--QNATVEFIAPSEYMLRPPQPaVYVFVIDISAAAIQSGYLHTFAEQLlinIDQMPGDDR-------SQV----- 446
Cdd:PLN00162  99 LPaELfpQYTTVEYTLPPGSGGAPSPP-VFVFVVDTCMIEEELGALKSALLQA---IALLPENALvglitfgTHVhvhel 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504  447 CF--------------IAVDQCLHFFSFSSNKRYPNEMIVDDIDDAFLPS-VTSLLVPMKKFKDTIRTFIKQLpefYSQI 511
Cdd:PLN00162 175 GFsecsksyvfrgnkeVSKDQILEQLGLGGKKRRPAGGGIAGARDGLSSSgVNRFLLPASECEFTLNSALEEL---QKDP 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566504  512 GPTSNGN----CLGSALKLAQSMIQE----VGGRISIFqVSLP-NLGLGALKSRE--ESTEGGQNLG--------PATDF 572
Cdd:PLN00162 252 WPVPPGHrparCTGAALSVAAGLLGAcvpgTGARIMAF-VGGPcTEGPGAIVSKDlsEPIRSHKDLDkdaapyykKAVKF 330

                        330
                 ....*....|....*...
gi 32566504  573 YKALSLECTGSQICLDLF 590
Cdd:PLN00162 331 YEGLAKQLVAQGHVLDVF 348
Gelsolin pfam00626
Gelsolin repeat;
860-911 3.69e-03

Gelsolin repeat;


Pssm-ID: 395501 [Multi-domain]  Cd Length: 76  Bit Score: 37.29  E-value: 3.69e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 32566504   860 PPALPLSFEHISRGGVYLMITGTIAFVYVASSADPgfLVNVFGTSTYNDIDE 911
Cdd:pfam00626   5 PPPVPLSQESLNSGDCYLLDNGFTIFLWVGKGSSL--LEKLFAALLAAQLDD 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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