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Conserved domains on  [gi|17561948|ref|NP_503352|]
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Flavin-containing monooxygenase [Caenorhabditis elegans]

Protein Classification

flavin-binding monooxygenase-like family protein( domain architecture ID 1000557)

flavin-binding monooxygenase-like family protein; such as flavin-containing monooxygenases (FMOs) that catalyze the monooxygenation of a variety of substrates

EC:  1.14.13.-
Gene Ontology:  GO:0004497

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FMO-like super family cl30939
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ...
 4-511 0e+00

Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.


The actual alignment was detected with superfamily member pfam00743:

Pssm-ID: 395602 [Multi-domain]  Cd Length: 531  Bit Score: 564.02  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948     4 KKQLLVVGAGASGLPSIRhALLHPNVEVTCFEKSGDIGGLWNFKPDQTD-LSTVMKSTVINTSKEMTAYSDFPPEDTMAN 82
Cdd:pfam00743   1 AKKVAVIGAGVSGLASIK-CCLEEGLEPTCFERSDDIGGLWRFTENVEEgRASIYKSVITNTSKEMSCFSDFPFPEDYPN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948    83 FMHNREMCRYLKSYAEHYGLLKHIKLNHSVVSIERNHDYSTTGKWKVrYTDESGKFHEKIFDGVMICSGHHAIPHIP-EP 161
Cdd:pfam00743  80 FMHNSKFLEYFRMFAKEFDLLKYIQFKTTVCSVKKRPDFSTSGQWEV-VTEHEGKQESAVFDAVMVCTGHHTNPHLPlES 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948   162 WPGQEKFKGRIIHSHDYKDHKGYEDKVIVVVGIGNSGGDCAVELSRIGKQVYLVTRRGSWIFSRLSDRGEPVDLVFNTKF 241
Cdd:pfam00743 159 FPGIEKFKGQYFHSRDYKHPEGFTGKRVLVIGIGNSGGDIAVELSHTAAQVFLSTRRGSWVLSRVSDHGYPWDMLFSTRF 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948   242 QMQLVDMIPSSIMNWNFERILNNKVDHEKYGLKPKHAAMAAHLTLNDELPNRIACGTVRVKPGIKSFTETGVQFDDGSFV 321
Cdd:pfam00743 239 TSFLRNILPTSISNWLMEKQMNRRFNHENYGLKPKNRALSKEPVVNDDLPNRILCGAVKVKPNVKEFTETSAIFEDGTVE 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948   322 EGVDEVILATGFSYHFDMIEgGKLIEVDENKSDIYKYVFPlATADHNTLAVIGLIQPLGSIMPISEMQARVYMESFANGM 401
Cdd:pfam00743 319 EDIDVVIFATGYTFAFPFLE-ESLVKVENNKVSLYKYVFP-PNLEKPTLAIIGLIQPLGSIIPTVELQARWATRVFKGLC 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948   402 KLPSKDQMLTDIAEKREIMSARYVASRRHTIQVDYASYMHELGEIIGCNPDMRSLWMWKPLTAWKVYFGPCVPYVFRLNG 481
Cdd:pfam00743 397 TLPSQSEMMAEINKRQEKKIKRFGDSQSHTIQTDYIDYMDELALFIGAKPNLLSLLLTDPKLALKLFFGPCTPYQYRLVG 476

                         490       500       510
                  ....*....|....*....|....*....|...
gi 17561948   482 PNKWEGAEAAI---WDvdyRSERATNSKIARKS 511
Cdd:pfam00743 477 PGKWEGARNAIltqWD---RILKPLKTRVVEKS 506
 
Name Accession Description Interval E-value
FMO-like pfam00743
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ...
 4-511 0e+00

Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.


Pssm-ID: 395602 [Multi-domain]  Cd Length: 531  Bit Score: 564.02  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948     4 KKQLLVVGAGASGLPSIRhALLHPNVEVTCFEKSGDIGGLWNFKPDQTD-LSTVMKSTVINTSKEMTAYSDFPPEDTMAN 82
Cdd:pfam00743   1 AKKVAVIGAGVSGLASIK-CCLEEGLEPTCFERSDDIGGLWRFTENVEEgRASIYKSVITNTSKEMSCFSDFPFPEDYPN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948    83 FMHNREMCRYLKSYAEHYGLLKHIKLNHSVVSIERNHDYSTTGKWKVrYTDESGKFHEKIFDGVMICSGHHAIPHIP-EP 161
Cdd:pfam00743  80 FMHNSKFLEYFRMFAKEFDLLKYIQFKTTVCSVKKRPDFSTSGQWEV-VTEHEGKQESAVFDAVMVCTGHHTNPHLPlES 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948   162 WPGQEKFKGRIIHSHDYKDHKGYEDKVIVVVGIGNSGGDCAVELSRIGKQVYLVTRRGSWIFSRLSDRGEPVDLVFNTKF 241
Cdd:pfam00743 159 FPGIEKFKGQYFHSRDYKHPEGFTGKRVLVIGIGNSGGDIAVELSHTAAQVFLSTRRGSWVLSRVSDHGYPWDMLFSTRF 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948   242 QMQLVDMIPSSIMNWNFERILNNKVDHEKYGLKPKHAAMAAHLTLNDELPNRIACGTVRVKPGIKSFTETGVQFDDGSFV 321
Cdd:pfam00743 239 TSFLRNILPTSISNWLMEKQMNRRFNHENYGLKPKNRALSKEPVVNDDLPNRILCGAVKVKPNVKEFTETSAIFEDGTVE 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948   322 EGVDEVILATGFSYHFDMIEgGKLIEVDENKSDIYKYVFPlATADHNTLAVIGLIQPLGSIMPISEMQARVYMESFANGM 401
Cdd:pfam00743 319 EDIDVVIFATGYTFAFPFLE-ESLVKVENNKVSLYKYVFP-PNLEKPTLAIIGLIQPLGSIIPTVELQARWATRVFKGLC 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948   402 KLPSKDQMLTDIAEKREIMSARYVASRRHTIQVDYASYMHELGEIIGCNPDMRSLWMWKPLTAWKVYFGPCVPYVFRLNG 481
Cdd:pfam00743 397 TLPSQSEMMAEINKRQEKKIKRFGDSQSHTIQTDYIDYMDELALFIGAKPNLLSLLLTDPKLALKLFFGPCTPYQYRLVG 476

                         490       500       510
                  ....*....|....*....|....*....|...
gi 17561948   482 PNKWEGAEAAI---WDvdyRSERATNSKIARKS 511
Cdd:pfam00743 477 PGKWEGARNAIltqWD---RILKPLKTRVVEKS 506
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 8-391 1.43e-74

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 241.69  E-value: 1.43e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948   8 LVVGAGASGLpSIRHALLHPNVEVTCFEKSGDIGGLW-NFKPDqtdlstvmkSTVINTSKEMTAYSDFPPEDTMANFMHN 86
Cdd:COG2072  10 VVIGAGQAGL-AAAYHLRRAGIDFVVLEKADDVGGTWrDNRYP---------GLRLDTPSHLYSLPFFPNWSDDPDFPTG 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948  87 REMCRYLKSYAEHYGLLKHIKLNHSVVSIERNHDystTGKWKVRYTDEsgkfHEKIFDGVMICSGHHAIPHIPEpWPGQE 166
Cdd:COG2072  80 DEILAYLEAYADKFGLRRPIRFGTEVTSARWDEA---DGRWTVTTDDG----ETLTARFVVVATGPLSRPKIPD-IPGLE 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948 167 KFKGRIIHSHDYKDHKGYEDKVIVVVGIGNSGGDCAVELSRIGKQVYLVTRRGSWIFSR---LSDRGEPVDLVFNTkFQM 243
Cdd:COG2072 152 DFAGEQLHSADWRNPVDLAGKRVLVVGTGASAVQIAPELARVAAHVTVFQRTPPWVLPRpnyDPERGRPANYLGLE-APP 230

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948 244 QLVDMipsSIMNWnFERILNNKVDHEKYG-LKPKHAAMAAHLTLNDELPNRIACGTVR-VKPGIKSFTETGVQFDDGSFV 321
Cdd:COG2072 231 ALNRR---DARAW-LRRLLRAQVKDPELGlLTPDYPPGCKRPLLSTDYYEALRRGNVElVTGGIERITEDGVVFADGTEH 306

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17561948 322 EgVDEVILATGFSYHFDMIEGGKLIEVDeNKSDI--YKYVfplATADHNTLAVIGLIQPLG--SIMPISEMQAR 391
Cdd:COG2072 307 E-VDVIVWATGFRADLPWLAPLDVRGRD-GRSGPraYLGV---VVPGFPNLFFLGPNSPSGhsSLTLGAERQAR 375
PLN02172 PLN02172
flavin-containing monooxygenase FMO GS-OX
 2-451 2.21e-39

flavin-containing monooxygenase FMO GS-OX


Pssm-ID: 215116 [Multi-domain]  Cd Length: 461  Bit Score: 148.86  E-value: 2.21e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948    2 VAKKQLLVVGAGASGLPSIRHaLLHPNVEVTCFEKSGDIGGLWNFKP----DQTDL--------STVMKSTVINTSKEMT 69
Cdd:PLN02172   8 INSQHVAVIGAGAAGLVAARE-LRREGHTVVVFEREKQVGGLWVYTPksesDPLSLdptrsivhSSVYESLRTNLPRECM 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948   70 AYSDFP----PEDTMAN---FMHNREMCRYLKSYAEHYGLLKHIKLNHSVVSIErnhdySTTGKWKVRYTDESGKFHEKI 142
Cdd:PLN02172  87 GYRDFPfvprFDDESRDsrrYPSHREVLAYLQDFAREFKIEEMVRFETEVVRVE-----PVDGKWRVQSKNSGGFSKDEI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948  143 FDGVMICSGHHAIP---HIP--EPWPGQEkfkgriIHSHDYKDHKGYEDKVIVVVGIGNSGGDCAVELSRIGKQVYLVTR 217
Cdd:PLN02172 162 FDAVVVCNGHYTEPnvaHIPgiKSWPGKQ------IHSHNYRVPDPFKNEVVVVIGNFASGADISRDIAKVAKEVHIASR 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948  218 -RGSWIFSRLSdrgepvdlvfntkfqmqlvdmIPSsimnwnferilNNKVDHEKyglkpkhaamaahltlndelpnriac 296
Cdd:PLN02172 236 aSESDTYEKLP---------------------VPQ-----------NNLWMHSE-------------------------- 257

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948  297 gtvrvkpgIKSFTETG-VQFDDGSFVEGvDEVILATGFSYHFDMIEGGKLIEVDENKSD-IYKYVFPLATADhnTLAVIG 374
Cdd:PLN02172 258 --------IDTAHEDGsIVFKNGKVVYA-DTIVHCTGYKYHFPFLETNGYMRIDENRVEpLYKHVFPPALAP--GLSFIG 326

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17561948  375 LiQPLGSIMPISEMQARVYMESFANGMKLPSKDQMLTDIAEKREIMSARYVASRR-HTIQVDYASYMHELGEIIGCNP 451
Cdd:PLN02172 327 L-PAMGIQFVMFEIQSKWVAAVLSGRVTLPSEDKMMEDINAWYASLEALGIPKRYtHKLGKIQSEYLNWIAEECGCPL 403
 
Name Accession Description Interval E-value
FMO-like pfam00743
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ...
 4-511 0e+00

Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.


Pssm-ID: 395602 [Multi-domain]  Cd Length: 531  Bit Score: 564.02  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948     4 KKQLLVVGAGASGLPSIRhALLHPNVEVTCFEKSGDIGGLWNFKPDQTD-LSTVMKSTVINTSKEMTAYSDFPPEDTMAN 82
Cdd:pfam00743   1 AKKVAVIGAGVSGLASIK-CCLEEGLEPTCFERSDDIGGLWRFTENVEEgRASIYKSVITNTSKEMSCFSDFPFPEDYPN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948    83 FMHNREMCRYLKSYAEHYGLLKHIKLNHSVVSIERNHDYSTTGKWKVrYTDESGKFHEKIFDGVMICSGHHAIPHIP-EP 161
Cdd:pfam00743  80 FMHNSKFLEYFRMFAKEFDLLKYIQFKTTVCSVKKRPDFSTSGQWEV-VTEHEGKQESAVFDAVMVCTGHHTNPHLPlES 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948   162 WPGQEKFKGRIIHSHDYKDHKGYEDKVIVVVGIGNSGGDCAVELSRIGKQVYLVTRRGSWIFSRLSDRGEPVDLVFNTKF 241
Cdd:pfam00743 159 FPGIEKFKGQYFHSRDYKHPEGFTGKRVLVIGIGNSGGDIAVELSHTAAQVFLSTRRGSWVLSRVSDHGYPWDMLFSTRF 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948   242 QMQLVDMIPSSIMNWNFERILNNKVDHEKYGLKPKHAAMAAHLTLNDELPNRIACGTVRVKPGIKSFTETGVQFDDGSFV 321
Cdd:pfam00743 239 TSFLRNILPTSISNWLMEKQMNRRFNHENYGLKPKNRALSKEPVVNDDLPNRILCGAVKVKPNVKEFTETSAIFEDGTVE 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948   322 EGVDEVILATGFSYHFDMIEgGKLIEVDENKSDIYKYVFPlATADHNTLAVIGLIQPLGSIMPISEMQARVYMESFANGM 401
Cdd:pfam00743 319 EDIDVVIFATGYTFAFPFLE-ESLVKVENNKVSLYKYVFP-PNLEKPTLAIIGLIQPLGSIIPTVELQARWATRVFKGLC 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948   402 KLPSKDQMLTDIAEKREIMSARYVASRRHTIQVDYASYMHELGEIIGCNPDMRSLWMWKPLTAWKVYFGPCVPYVFRLNG 481
Cdd:pfam00743 397 TLPSQSEMMAEINKRQEKKIKRFGDSQSHTIQTDYIDYMDELALFIGAKPNLLSLLLTDPKLALKLFFGPCTPYQYRLVG 476

                         490       500       510
                  ....*....|....*....|....*....|...
gi 17561948   482 PNKWEGAEAAI---WDvdyRSERATNSKIARKS 511
Cdd:pfam00743 477 PGKWEGARNAIltqWD---RILKPLKTRVVEKS 506
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 8-391 1.43e-74

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 241.69  E-value: 1.43e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948   8 LVVGAGASGLpSIRHALLHPNVEVTCFEKSGDIGGLW-NFKPDqtdlstvmkSTVINTSKEMTAYSDFPPEDTMANFMHN 86
Cdd:COG2072  10 VVIGAGQAGL-AAAYHLRRAGIDFVVLEKADDVGGTWrDNRYP---------GLRLDTPSHLYSLPFFPNWSDDPDFPTG 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948  87 REMCRYLKSYAEHYGLLKHIKLNHSVVSIERNHDystTGKWKVRYTDEsgkfHEKIFDGVMICSGHHAIPHIPEpWPGQE 166
Cdd:COG2072  80 DEILAYLEAYADKFGLRRPIRFGTEVTSARWDEA---DGRWTVTTDDG----ETLTARFVVVATGPLSRPKIPD-IPGLE 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948 167 KFKGRIIHSHDYKDHKGYEDKVIVVVGIGNSGGDCAVELSRIGKQVYLVTRRGSWIFSR---LSDRGEPVDLVFNTkFQM 243
Cdd:COG2072 152 DFAGEQLHSADWRNPVDLAGKRVLVVGTGASAVQIAPELARVAAHVTVFQRTPPWVLPRpnyDPERGRPANYLGLE-APP 230

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948 244 QLVDMipsSIMNWnFERILNNKVDHEKYG-LKPKHAAMAAHLTLNDELPNRIACGTVR-VKPGIKSFTETGVQFDDGSFV 321
Cdd:COG2072 231 ALNRR---DARAW-LRRLLRAQVKDPELGlLTPDYPPGCKRPLLSTDYYEALRRGNVElVTGGIERITEDGVVFADGTEH 306

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17561948 322 EgVDEVILATGFSYHFDMIEGGKLIEVDeNKSDI--YKYVfplATADHNTLAVIGLIQPLG--SIMPISEMQAR 391
Cdd:COG2072 307 E-VDVIVWATGFRADLPWLAPLDVRGRD-GRSGPraYLGV---VVPGFPNLFFLGPNSPSGhsSLTLGAERQAR 375
PLN02172 PLN02172
flavin-containing monooxygenase FMO GS-OX
 2-451 2.21e-39

flavin-containing monooxygenase FMO GS-OX


Pssm-ID: 215116 [Multi-domain]  Cd Length: 461  Bit Score: 148.86  E-value: 2.21e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948    2 VAKKQLLVVGAGASGLPSIRHaLLHPNVEVTCFEKSGDIGGLWNFKP----DQTDL--------STVMKSTVINTSKEMT 69
Cdd:PLN02172   8 INSQHVAVIGAGAAGLVAARE-LRREGHTVVVFEREKQVGGLWVYTPksesDPLSLdptrsivhSSVYESLRTNLPRECM 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948   70 AYSDFP----PEDTMAN---FMHNREMCRYLKSYAEHYGLLKHIKLNHSVVSIErnhdySTTGKWKVRYTDESGKFHEKI 142
Cdd:PLN02172  87 GYRDFPfvprFDDESRDsrrYPSHREVLAYLQDFAREFKIEEMVRFETEVVRVE-----PVDGKWRVQSKNSGGFSKDEI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948  143 FDGVMICSGHHAIP---HIP--EPWPGQEkfkgriIHSHDYKDHKGYEDKVIVVVGIGNSGGDCAVELSRIGKQVYLVTR 217
Cdd:PLN02172 162 FDAVVVCNGHYTEPnvaHIPgiKSWPGKQ------IHSHNYRVPDPFKNEVVVVIGNFASGADISRDIAKVAKEVHIASR 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948  218 -RGSWIFSRLSdrgepvdlvfntkfqmqlvdmIPSsimnwnferilNNKVDHEKyglkpkhaamaahltlndelpnriac 296
Cdd:PLN02172 236 aSESDTYEKLP---------------------VPQ-----------NNLWMHSE-------------------------- 257

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948  297 gtvrvkpgIKSFTETG-VQFDDGSFVEGvDEVILATGFSYHFDMIEGGKLIEVDENKSD-IYKYVFPLATADhnTLAVIG 374
Cdd:PLN02172 258 --------IDTAHEDGsIVFKNGKVVYA-DTIVHCTGYKYHFPFLETNGYMRIDENRVEpLYKHVFPPALAP--GLSFIG 326

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17561948  375 LiQPLGSIMPISEMQARVYMESFANGMKLPSKDQMLTDIAEKREIMSARYVASRR-HTIQVDYASYMHELGEIIGCNP 451
Cdd:PLN02172 327 L-PAMGIQFVMFEIQSKWVAAVLSGRVTLPSEDKMMEDINAWYASLEALGIPKRYtHKLGKIQSEYLNWIAEECGCPL 403
Pyr_redox_3 pfam13738
Pyridine nucleotide-disulphide oxidoreductase;
87-352 2.78e-19

Pyridine nucleotide-disulphide oxidoreductase;


Pssm-ID: 404603 [Multi-domain]  Cd Length: 296  Bit Score: 88.43  E-value: 2.78e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948    87 REMCRYLKSYAEHYGLlkHIKLNHSVVSIERNHDY----STTGKWKVRYtdesgkfhekifdgVMICSGHHAIPHIPEpw 162
Cdd:pfam13738  75 NEYAEYLRRVADHFEL--PINLFEEVTSVKKEDDGfvvtTSKGTYQARY--------------VIIATGEFDFPNKLG-- 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948   163 pgqekFKGRIIHSHDYKDHKGYEDKVIVVVGIGNSGGDCAVELSRIGKQVYLVTRRGSWifsrlsdrgepvdlvfntkfq 242
Cdd:pfam13738 137 -----VPELPKHYSYVKDFHPYAGQKVVVIGGYNSAVDAALELVRKGARVTVLYRGSEW--------------------- 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948   243 mqlvdmipssimnwnferilNNKVDHEKYGLKPkhaamaahLTLNdELPNRIACGTVRVKPG--IKSFTETG----VQFD 316
Cdd:pfam13738 191 --------------------EDRDSDPSYSLSP--------DTLN-RLEELVKNGKIKAHFNaeVKEITEVDvsykVHTE 241

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 17561948   317 DGSFVEGVDEVILATGFSYHFDMIEGGkLIEVDENK 352
Cdd:pfam13738 242 DGRKVTSNDDPILATGYHPDLSFLKKG-LFELDEDG 276
TrxB COG0492
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];
87-218 2.78e-09

Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440258 [Multi-domain]  Cd Length: 305  Bit Score: 58.59  E-value: 2.78e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948  87 REMCRYLKSYAEHYGLlkHIKLNHsVVSIERNHDYsttgkWKVRyTDESGKFHekiFDGVMICSGHHAIPHipePWPGQE 166
Cdd:COG0492  57 PELAERLREQAERFGA--EILLEE-VTSVDKDDGP-----FRVT-TDDGTEYE---AKAVIIATGAGPRKL---GLPGEE 121

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 17561948 167 KFKGRIIHSHDYKDHKGYEDKVIVVVGIGNSGGDCAVELSRIGKQVYLVTRR 218
Cdd:COG0492 122 EFEGRGVSYCATCDGFFFRGKDVVVVGGGDSALEEALYLTKFASKVTLIHRR 173
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 5-326 2.57e-08

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 55.40  E-value: 2.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948     5 KQLLVVGAGASGLPSIRHALLHpNVEVTCFEksgdIGGLW-NFKPdqtdlstVMkstvintSKEMTAYSDFPPEDTM-AN 82
Cdd:pfam07992   1 YDVVVIGGGPAGLAAALTLAQL-GGKVTLIE----DEGTCpYGGC-------VL-------SKALLGAAEAPEIASLwAD 61

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948    83 FMHNREmcRYLKSYAEHYGLLkhikLNHSVVSIERnhdysttGKWKVRYTDESGKFHEKI-FDGVMICSGhhAIPHIPeP 161
Cdd:pfam07992  62 LYKRKE--EVVKKLNNGIEVL----LGTEVVSIDP-------GAKKVVLEELVDGDGETItYDRLVIATG--ARPRLP-P 125

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948   162 WPGQEKFKGRIIHSHD----YKDHKGyeDKVIVVVGIGNSGGDCAVELSRIGKQVYLVTRRgSWIFSRLsdrGEPVDLVF 237
Cdd:pfam07992 126 IPGVELNVGFLVRTLDsaeaLRLKLL--PKRVVVVGGGYIGVELAAALAKLGKEVTLIEAL-DRLLRAF---DEEISAAL 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948   238 NTKFQMQLVDMipssIMNWNFERILNNKVDHEkyglkpkhaamaahLTLNDElpNRIACGTVRV----KPGIKSFTETGV 313
Cdd:pfam07992 200 EKALEKNGVEV----RLGTSVKEIIGDGDGVE--------------VILKDG--TEIDADLVVVaigrRPNTELLEAAGL 259

                         330
                  ....*....|...
gi 17561948   314 QFDDGSFVEgVDE 326
Cdd:pfam07992 260 ELDERGGIV-VDE 271
YdhS COG4529
Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];
1-219 1.28e-05

Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];


Pssm-ID: 443597 [Multi-domain]  Cd Length: 466  Bit Score: 47.64  E-value: 1.28e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948   1 MVAKKQLLVVGAGASGLpSIRHALL---HPNVEVTCFEKSGDIG-GLwnfkPDQTDLSTVmkstVINT-SKEMTAYSDFP 75
Cdd:COG4529   2 TGARKRIAIIGGGASGT-ALAIHLLrraPEPLRITLFEPRPELGrGV----AYSTDSPEH----LLNVpAGRMSAFPDDP 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948  76 peDTMANFMHNREMC-----------------RYLKSYAEHY--GLLKHIKLNH---SVVSIERnhdysTTGKWKVRytD 133
Cdd:COG4529  73 --DHFLRWLRENGARaapaidpdafvprrlfgEYLRERLAEAlaRAPAGVRLRHiraEVVDLER-----DDGGYRVT--L 143

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948 134 ESGkfHEKIFDGVMICSGHhaiphiPEPWPgqekfkgriiHSHDYKDHKGY--------------EDKVIVVVGIGNSGG 199
Cdd:COG4529 144 ADG--ETLRADAVVLATGH------PPPAP----------PPGLAAGSPRYiadpwppgalaripPDARVLIIGTGLTAI 205

                       250       260
                ....*....|....*....|..
gi 17561948 200 DCAVELSRIGK--QVYLVTRRG 219
Cdd:COG4529 206 DVVLSLAARGHrgPITALSRRG 227
Pyr_redox pfam00070
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 189-240 1.07e-04

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 425450 [Multi-domain]  Cd Length: 80  Bit Score: 40.65  E-value: 1.07e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17561948   189 IVVVGIGNSGGDCAVELSRIGKQVYLVTRR-----------GSWIFSRLSDRGepVDLVFNTK 240
Cdd:pfam00070   2 VVVVGGGYIGLELAGALARLGSKVTVVERRdrllpgfdpeiAKILQEKLEKNG--IEFLLNTT 62
Lys_Orn_oxgnase pfam13434
L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase; This is a family of Rossmann fold ...
 87-335 2.16e-04

L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase; This is a family of Rossmann fold oxidoreductases that catalyze NADPH-dependent hydroxylation and are involved in siderophore biosynthesis. This family includes L-ornithine 5-monooxygenase, which catalyzes the hydroxylation of L-ornithine at the N5 position, and L-lysine 6-monooxygenase, which catalyzes the hydroxylation of lysine at the N6 position (EC:1.14.13.59).


Pssm-ID: 433204 [Multi-domain]  Cd Length: 338  Bit Score: 43.34  E-value: 2.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948    87 REMCRYLKSYAEHygLLKHIKLNHSVVSIErNHDYSTTGKWKVRYTDESGKFHEkiFDGVMICSGHHAIPHIPEPWPGqe 166
Cdd:pfam13434  95 REFNDYLQWAASH--LPNRLRFGQEVESVE-PDAERGEPLLRVRVRDADGEETT--FLARNLVLGTGGEPYIPECARG-- 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948   167 kfKGRIIHSHDYKDHKGY--EDKVIVVVGIGNSGG----DCaveLSRIGK-QVYLVTRRGSWifsrlsdrgEPVDlvfNT 239
Cdd:pfam13434 168 --GERVFHSSEYLERIDRlaAKKRIAVVGSGQSAAeifrDL---LRRGPAyELTWVTRSPNF---------FPLD---DS 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948   240 KFQMQLVDmiPSSImNWNFERILNNKVDHEKYGLKPKHAAMAAHL--TLNDELPNRIACGTVRVK-------PGIKSFTE 310
Cdd:pfam13434 231 PFVNEIFS--PEYV-DYFYSLPEDTRRALLREQKGTNYDGIDPSLieEIYRLLYEQRVDGDPRHRllpnrevQSAERVGD 307

                         250       260       270
                  ....*....|....*....|....*....|.
gi 17561948   311 TGVQ------FDDGSFVEGVDEVILATGFSY 335
Cdd:pfam13434 308 GGVEltlrdgEQGREETLETDVVVLATGYRR 338
NAD_binding_9 pfam13454
FAD-NAD(P)-binding;
9-152 3.80e-04

FAD-NAD(P)-binding;


Pssm-ID: 433222 [Multi-domain]  Cd Length: 155  Bit Score: 41.11  E-value: 3.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948     9 VVGAGASGLPSIRHAL---LHPNVEVTCFEKSGD-IGGLWNfkpdqTDLSTVMKstvINT-SKEMTAYSDFPPedTMANF 83
Cdd:pfam13454   2 IVGGGPSGLALLERLLaraPKRPLEITLFDPSPPgAGGVYR-----TDQSPEHL---LNVpASRMSLFPDDPP--HFLEW 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948    84 MHNREMC------------------RYLKSYAEHY--GLLKHIKLNH---SVVSIERNHDysttgKWKVRYTDesGKFHE 140
Cdd:pfam13454  72 LRARGALdeapgldpddfppralygRYLRDRFEEAlaRAPAGVTVRVhraRVTDLRPRGD-----GYRVLLAD--GRTLA 144

                         170
                  ....*....|..
gi 17561948   141 kiFDGVMICSGH 152
Cdd:pfam13454 145 --ADAVVLATGH 154
PRK10262 PRK10262
thioredoxin reductase; Provisional
 130-246 5.00e-04

thioredoxin reductase; Provisional


Pssm-ID: 182343 [Multi-domain]  Cd Length: 321  Bit Score: 42.36  E-value: 5.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561948  130 RYTDESGKFhekIFDGVMICSGHHAIPHipePWPGQEKFKGRIIHSHDYKDHKGYEDKVIVVVGIGNSGGDCAVELSRIG 209
Cdd:PRK10262  96 RLTGDSGEY---TCDALIIATGASARYL---GLPSEEAFKGRGVSACATCDGFFYRNQKVAVIGGGNTAVEEALYLSNIA 169

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 17561948  210 KQVYLVTRRGSW-----IFSRLSDRGEPVDLVFNTKFQMQLV 246
Cdd:PRK10262 170 SEVHLIHRRDGFraekiLIKRLMDKVENGNIILHTNRTLEEV 211
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
9-44 2.07e-03

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 36.74  E-value: 2.07e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 17561948     9 VVGAGASGLpSIRHALLHPNVEVTCFEKSGDIGGLW 44
Cdd:pfam13450   1 IVGAGLAGL-VAAALLAKRGFRVLVLEKRDRLGGNA 35
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 4-43 2.46e-03

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 40.20  E-value: 2.46e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 17561948   4 KKQLLVVGAGASGLpSIRHALLHPNVEVTCFEKSGDIGGL 43
Cdd:COG1232   1 MKRVAVIGGGIAGL-TAAYRLAKAGHEVTVLEASDRVGGL 39
PRK05257 PRK05257
malate:quinone oxidoreductase; Validated
 105-160 5.87e-03

malate:quinone oxidoreductase; Validated


Pssm-ID: 179979  Cd Length: 494  Bit Score: 39.35  E-value: 5.87e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17561948  105 HIKLNHSVVSIERNHDysttGKWKVRYTD-ESGKFHEKIFDGVMICSGHHAIP-----HIPE 160
Cdd:PRK05257 200 ELQLGHEVRDIKRNDD----GSWTVTVKDlKTGEKRTVRAKFVFIGAGGGALPllqksGIPE 257
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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