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Conserved domains on  [gi|32566849|ref|NP_505927|]
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C3H1-type domain-containing protein [Caenorhabditis elegans]

Protein Classification

CTH1 family zinc finger protein( domain architecture ID 1004917)

CTH1 family zinc finger protein similar to Homo sapiens mRNA decay activator protein ZFP36 that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis

CATH:  4.10.1000.10
Gene Ontology:  GO:0046872|GO:0003676
PubMed:  12665246|11179890
SCOP:  4003893

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
CTH1 super family cl34885
CCCH-type Zn-finger protein [General function prediction only];
151-222 2.89e-11

CCCH-type Zn-finger protein [General function prediction only];


The actual alignment was detected with superfamily member COG5063:

Pssm-ID: 227395 [Multi-domain]  Cd Length: 351  Bit Score: 64.30  E-value: 2.89e-11
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 32566849 151 PPKNPKLYKTELCRSWMDHGRCNYGERCQYAHGELEKRPVPRHP--KYKTEACQSFHQSGYCPYGPRCHFIHNE 222
Cdd:COG5063 265 SKKKKQNFRTEPCINWEKSGYCPYGLRCCFKHGDDSDIEMYEEAslGYLDGPCRTRAKGGAFPSGGAVCKSFDK 338
 
Name Accession Description Interval E-value
CTH1 COG5063
CCCH-type Zn-finger protein [General function prediction only];
151-222 2.89e-11

CCCH-type Zn-finger protein [General function prediction only];


Pssm-ID: 227395 [Multi-domain]  Cd Length: 351  Bit Score: 64.30  E-value: 2.89e-11
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 32566849 151 PPKNPKLYKTELCRSWMDHGRCNYGERCQYAHGELEKRPVPRHP--KYKTEACQSFHQSGYCPYGPRCHFIHNE 222
Cdd:COG5063 265 SKKKKQNFRTEPCINWEKSGYCPYGLRCCFKHGDDSDIEMYEEAslGYLDGPCRTRAKGGAFPSGGAVCKSFDK 338
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
196-222 1.34e-09

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 52.97  E-value: 1.34e-09
                          10        20
                  ....*....|....*....|....*..
gi 32566849   196 YKTEACQSFHQSGYCPYGPRCHFIHNE 222
Cdd:pfam00642   1 YKTELCRFFLRTGYCKYGDRCKFAHGQ 27
ZnF_C3H1 smart00356
zinc finger;
195-222 1.39e-07

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 47.24  E-value: 1.39e-07
                           10        20
                   ....*....|....*....|....*...
gi 32566849    195 KYKTEACQSFhQSGYCPYGPRCHFIHNE 222
Cdd:smart00356   1 KYKTELCKFF-KRGYCPRGDRCKFAHPL 27
 
Name Accession Description Interval E-value
CTH1 COG5063
CCCH-type Zn-finger protein [General function prediction only];
151-222 2.89e-11

CCCH-type Zn-finger protein [General function prediction only];


Pssm-ID: 227395 [Multi-domain]  Cd Length: 351  Bit Score: 64.30  E-value: 2.89e-11
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 32566849 151 PPKNPKLYKTELCRSWMDHGRCNYGERCQYAHGELEKRPVPRHP--KYKTEACQSFHQSGYCPYGPRCHFIHNE 222
Cdd:COG5063 265 SKKKKQNFRTEPCINWEKSGYCPYGLRCCFKHGDDSDIEMYEEAslGYLDGPCRTRAKGGAFPSGGAVCKSFDK 338
CTH1 COG5063
CCCH-type Zn-finger protein [General function prediction only];
129-246 2.62e-10

CCCH-type Zn-finger protein [General function prediction only];


Pssm-ID: 227395 [Multi-domain]  Cd Length: 351  Bit Score: 61.61  E-value: 2.62e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566849 129 SASSPYStPQLTPMATPNGQAPPPKNpkLYKTELCRSWMDHGRCNYGERCQYAHGELEKRPVPRHPKYKTEACQSFHQSG 208
Cdd:COG5063  87 SSASSNS-PQNYPWSPRGSNANKPYG--LYKTEMLRSSTEIPYCRYPDKNPFAHSKAISSLAQTHPKYKTESLEVFINPG 163

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 32566849 209 YCPYGPRCHFIH-------NEPPSAQSQYSTPISTPVPHQTTPSL 246
Cdd:COG5063 164 YVPYSKRCCFISlpltdinLQPLSQRKPKSGKNCTSYTLGKESDA 208
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
196-222 1.34e-09

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 52.97  E-value: 1.34e-09
                          10        20
                  ....*....|....*....|....*..
gi 32566849   196 YKTEACQSFHQSGYCPYGPRCHFIHNE 222
Cdd:pfam00642   1 YKTELCRFFLRTGYCKYGDRCKFAHGQ 27
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
158-184 3.56e-09

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 51.81  E-value: 3.56e-09
                          10        20
                  ....*....|....*....|....*..
gi 32566849   158 YKTELCRSWMDHGRCNYGERCQYAHGE 184
Cdd:pfam00642   1 YKTELCRFFLRTGYCKYGDRCKFAHGQ 27
ZnF_C3H1 smart00356
zinc finger;
195-222 1.39e-07

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 47.24  E-value: 1.39e-07
                           10        20
                   ....*....|....*....|....*...
gi 32566849    195 KYKTEACQSFhQSGYCPYGPRCHFIHNE 222
Cdd:smart00356   1 KYKTELCKFF-KRGYCPRGDRCKFAHPL 27
ZnF_C3H1 smart00356
zinc finger;
158-184 4.90e-07

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 45.70  E-value: 4.90e-07
                           10        20
                   ....*....|....*....|....*..
gi 32566849    158 YKTELCRSWMdHGRCNYGERCQYAHGE 184
Cdd:smart00356   2 YKTELCKFFK-RGYCPRGDRCKFAHPL 27
CTH1 COG5063
CCCH-type Zn-finger protein [General function prediction only];
154-220 3.27e-05

CCCH-type Zn-finger protein [General function prediction only];


Pssm-ID: 227395 [Multi-domain]  Cd Length: 351  Bit Score: 45.81  E-value: 3.27e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 32566849 154 NPKLYKT--ELCRSWMDHGRCNY---GERCQYA---HGELEKRPVPRHPKYKTEACQSFHQSGYCPYGPRCHFIH 220
Cdd:COG5063 222 NKPLYKTnpELCESFTRKGTCPYwisGVKCQFAcrgHGLNELKSKKKKQNFRTEPCINWEKSGYCPYGLRCCFKH 296
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 163-182 2.77e-04

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 37.78  E-value: 2.77e-04
                          10        20
                  ....*....|....*....|
gi 32566849   163 CRSWMdHGRCNYGERCQYAH 182
Cdd:pfam18345   1 CKFFL-KGRCRYGDKCRFAH 19
YTH1 COG5084
Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin ...
 152-226 3.41e-03

Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins [General function prediction only];


Pssm-ID: 227416 [Multi-domain]  Cd Length: 285  Bit Score: 39.08  E-value: 3.41e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 32566849 152 PKNPKLYKTELCRSWmDHGRCNYGERCQYAHGelekrpvPRHPKYKTEACQSFHQSGYCPYGPRCHFIHNEPPSA 226
Cdd:COG5084  96 HVNPVLSSSVVCKFF-LRGLCKSGFSCEFLHE-------YDLRSSQGPPCRSFSLKGSCSSGPSCGYSHIDPDSF 162
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 201-220 4.30e-03

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 34.31  E-value: 4.30e-03
                          10        20
                  ....*....|....*....|
gi 32566849   201 CQSFHQsGYCPYGPRCHFIH 220
Cdd:pfam18345   1 CKFFLK-GRCRYGDKCRFAH 19
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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