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Conserved domains on  [gi|21553123|ref|NP_660139|]
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beta-defensin 19 precursor [Mus musculus]

Protein Classification

Defensin_big domain-containing protein( domain architecture ID 10632787)

Defensin_big domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Defensin_big pfam14862
Big defensin; Big defensins are antimicrobial peptides. They consist of a hydrophobic ...
 14-51 2.28e-14

Big defensin; Big defensins are antimicrobial peptides. They consist of a hydrophobic N-terminal half, which is active against Gram-positive bacteria, and a cationic C-terminal half, which is active against Gram-negative bacteria. The C-terminal half adopts a beta-defensin-like structure.


:

Pssm-ID: 373348  Cd Length: 55  Bit Score: 61.10  E-value: 2.28e-14
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 21553123   14 TELVVSGKNPILQCMGNRGFCRSSCKKSEQAYFYCRTF 51
Cdd:pfam14862 18 AAVVRSGKNDTLQCGKNRGFCRPKCKKEEQAYFYCRTP 55
 
Name Accession Description Interval E-value
Defensin_big pfam14862
Big defensin; Big defensins are antimicrobial peptides. They consist of a hydrophobic ...
 14-51 2.28e-14

Big defensin; Big defensins are antimicrobial peptides. They consist of a hydrophobic N-terminal half, which is active against Gram-positive bacteria, and a cationic C-terminal half, which is active against Gram-negative bacteria. The C-terminal half adopts a beta-defensin-like structure.


Pssm-ID: 373348  Cd Length: 55  Bit Score: 61.10  E-value: 2.28e-14
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 21553123   14 TELVVSGKNPILQCMGNRGFCRSSCKKSEQAYFYCRTF 51
Cdd:pfam14862 18 AAVVRSGKNDTLQCGKNRGFCRPKCKKEEQAYFYCRTP 55
 
Name Accession Description Interval E-value
Defensin_big pfam14862
Big defensin; Big defensins are antimicrobial peptides. They consist of a hydrophobic ...
 14-51 2.28e-14

Big defensin; Big defensins are antimicrobial peptides. They consist of a hydrophobic N-terminal half, which is active against Gram-positive bacteria, and a cationic C-terminal half, which is active against Gram-negative bacteria. The C-terminal half adopts a beta-defensin-like structure.


Pssm-ID: 373348  Cd Length: 55  Bit Score: 61.10  E-value: 2.28e-14
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 21553123   14 TELVVSGKNPILQCMGNRGFCRSSCKKSEQAYFYCRTF 51
Cdd:pfam14862 18 AAVVRSGKNDTLQCGKNRGFCRPKCKKEEQAYFYCRTP 55
Defensin_beta_2 pfam13841
Beta defensin; The beta defensins are antimicrobial peptides implicated in the resistance of ...
 27-55 4.57e-05

Beta defensin; The beta defensins are antimicrobial peptides implicated in the resistance of epithelial surfaces to microbial colonization.


Pssm-ID: 463997  Cd Length: 30  Bit Score: 36.57  E-value: 4.57e-05
                         10        20
                 ....*....|....*....|....*....
gi 21553123   27 CMGNRGFCRSSCKKSEQAYFYCRTFQMCC 55
Cdd:pfam13841  2 CWKGRGHCRKKCLKNEYYIGYCRNGTLCC 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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