NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|40255133|ref|NP_689963|]
View 

cadherin-related family member 3 isoform 1 precursor [Homo sapiens]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 10182011)

cadherin repeat domain-containing protein similar to Homo sapiens desmoglein-2, which is involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; cadherins are are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  17158740|28268172|27782885|11736639
SCOP:  4007535

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 465-561 3.55e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.61  E-value: 3.55e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255133 465 SYVFDVSERRPARTRVGQVRATDKDLPQSSLL-YSISTGGAslqyPNVFWINPKTGELQLVTKVDCETTPIYILRIQATN 543
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVtYSIVSGNE----DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|.
gi 40255133 544 NED---TSSVTVTVNILEEND 561
Cdd:cd11304  77 GGGpplSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 242-341 5.32e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 5.32e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255133 242 VYTVLEELSPGTIVANITAEDPdDEGFPSHLLYSIT--TVSKYFMINQLTGTIQVAQRIDRDagelrQNPTISLEVLVKD 319
Cdd:cd11304   3 EVSVPENAPPGTVVLTVSATDP-DSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDRE-----EQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|..
gi 40255133 320 RPYGGQENRIQITFIVEDVNDN 341
Cdd:cd11304  77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 141-231 1.17e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 67.34  E-value: 1.17e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255133 141 HLYIVERANPG-FIYQVEAFDPeDTSRNIPLSYFLISPPKS--FRMSAN-GTLFSTTELDFEAgHRSFHLIVEVRDSGG- 215
Cdd:cd11304   3 EVSVPENAPPGtVVLTVSATDP-DSGENGEVTYSIVSGNEDglFSIDPStGEITTAKPLDREE-QSSYTLTVTATDGGGp 80

                        90
                ....*....|....*..
gi 40255133 216 -LKASTELQVNIVNLND 231
Cdd:cd11304  81 pLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 570-679 4.61e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 51.55  E-value: 4.61e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255133 570 SYFLALPVDLKVGTNIqnFKLTCTDLDSSPRS-FRYSIGPGNVNNHFTFSPNAGsnvtRLLLTSRFDYaggfDKIWDYKL 648
Cdd:cd11304   1 SYEVSVPENAPPGTVV--LTVSATDPDSGENGeVTYSIVSGNEDGLFSIDPSTG----EITTAKPLDR----EEQSSYTL 70

                        90       100       110
                ....*....|....*....|....*....|.
gi 40255133 649 LVYVTDDNLMSdrkkaealvETGTVTLSIKV 679
Cdd:cd11304  71 TVTATDGGGPP---------LSSTATVTITV 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 26-128 1.54e-06

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 47.31  E-value: 1.54e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255133  26 PATGNVAENSPPGTSVHKFSVKlSASLSPVIPGFPQIVNSNPLtEAFRVNWLSGtyfEVVTTGmeQLDFETGPNiFDLQI 105
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSAT-DPDSGENGEVTYSIVSGNED-GLFSIDPSTG---EITTAK--PLDREEQSS-YTLTV 72

                        90       100
                ....*....|....*....|....*
gi 40255133 106 YVKDEVG--VTDLQVLTVQVTDVNE 128
Cdd:cd11304  73 TATDGGGppLSSTATVTITVLDVND 97
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 465-561 3.55e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.61  E-value: 3.55e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255133 465 SYVFDVSERRPARTRVGQVRATDKDLPQSSLL-YSISTGGAslqyPNVFWINPKTGELQLVTKVDCETTPIYILRIQATN 543
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVtYSIVSGNE----DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|.
gi 40255133 544 NED---TSSVTVTVNILEEND 561
Cdd:cd11304  77 GGGpplSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 242-341 5.32e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 5.32e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255133 242 VYTVLEELSPGTIVANITAEDPdDEGFPSHLLYSIT--TVSKYFMINQLTGTIQVAQRIDRDagelrQNPTISLEVLVKD 319
Cdd:cd11304   3 EVSVPENAPPGTVVLTVSATDP-DSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDRE-----EQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|..
gi 40255133 320 RPYGGQENRIQITFIVEDVNDN 341
Cdd:cd11304  77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
466-557 1.52e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.41  E-value: 1.52e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255133   466 YVFDVSERRPARTRVGQVRATDKDLPQ-SSLLYSISTGGASlqypNVFWINPKTGELQLVTKVDCETTPIYILRIQATNN 544
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPnGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 40255133   545 E---DTSSVTVTVNIL 557
Cdd:pfam00028  77 GgppLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 484-564 3.60e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.53  E-value: 3.60e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255133    484 RATDKDLPQSSLL-YSISTGGAslqyPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNN---EDTSSVTVTVNILEE 559
Cdd:smart00112   1 SATDADSGENGKVtYSILSGND----DGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGggpPLSSTATVTITVLDV 76


                   ....*
gi 40255133    560 NDEKP 564
Cdd:smart00112  77 NDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 141-231 1.17e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 67.34  E-value: 1.17e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255133 141 HLYIVERANPG-FIYQVEAFDPeDTSRNIPLSYFLISPPKS--FRMSAN-GTLFSTTELDFEAgHRSFHLIVEVRDSGG- 215
Cdd:cd11304   3 EVSVPENAPPGtVVLTVSATDP-DSGENGEVTYSIVSGNEDglFSIDPStGEITTAKPLDREE-QSSYTLTVTATDGGGp 80

                        90
                ....*....|....*..
gi 40255133 216 -LKASTELQVNIVNLND 231
Cdd:cd11304  81 pLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 259-342 1.66e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 60.83  E-value: 1.66e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255133    259 TAEDPDDeGFPSHLLYSIT--TVSKYFMINQLTGTIQVAQRIDRDagelrQNPTISLEVLVKDRPYGGQENRIQITFIVE 336
Cdd:smart00112   1 SATDADS-GENGKVTYSILsgNDDGLFSIDPETGEITTTKPLDRE-----EQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ....*.
gi 40255133    337 DVNDNP 342
Cdd:smart00112  75 DVNDNA 80
Cadherin pfam00028
Cadherin domain;
241-336 6.32e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 56.54  E-value: 6.32e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255133   241 RVYTVLEELSPGTIVANITAEDPdDEGFPSHLLYSITT--VSKYFMINQLTGTIQVAQRIDRDagelrQNPTISLEVLVK 318
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDP-DLGPNGRIFYSILGggPGGNFRIDPDTGDISTTKPLDRE-----SIGEYELTVEAT 74

                          90
                  ....*....|....*...
gi 40255133   319 DRPYGGQENRIQITFIVE 336
Cdd:pfam00028  75 DSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 158-234 2.98e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 51.58  E-value: 2.98e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255133    158 AFDPeDTSRNIPLSYFLIS--PPKSFRMSAN-GTLFSTTELDFEAGHRsFHLIVEVRDSGG--LKASTELQVNIVNLNDE 232
Cdd:smart00112   2 ATDA-DSGENGKVTYSILSgnDDGLFSIDPEtGEITTTKPLDREEQPE-YTLTVEATDGGGppLSSTATVTITVLDVNDN 79


                   ..
gi 40255133    233 VP 234
Cdd:smart00112  80 AP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 570-679 4.61e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 51.55  E-value: 4.61e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255133 570 SYFLALPVDLKVGTNIqnFKLTCTDLDSSPRS-FRYSIGPGNVNNHFTFSPNAGsnvtRLLLTSRFDYaggfDKIWDYKL 648
Cdd:cd11304   1 SYEVSVPENAPPGTVV--LTVSATDPDSGENGeVTYSIVSGNEDGLFSIDPSTG----EITTAKPLDR----EEQSSYTL 70

                        90       100       110
                ....*....|....*....|....*....|.
gi 40255133 649 LVYVTDDNLMSdrkkaealvETGTVTLSIKV 679
Cdd:cd11304  71 TVTATDGGGPP---------LSSTATVTITV 92
Cadherin pfam00028
Cadherin domain;
141-226 1.20e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 50.38  E-value: 1.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255133   141 HLYIVERANPG-FIYQVEAFDPeDTSRNIPLSYFLIS--PPKSFRM-SANGTLFSTTELDFEAGhRSFHLIVEVRDSGGL 216
Cdd:pfam00028   2 SASVPENAPVGtEVLTVTATDP-DLGPNGRIFYSILGggPGGNFRIdPDTGDISTTKPLDRESI-GEYELTVEATDSGGP 79

                          90
                  ....*....|
gi 40255133   217 KASTELQVNI 226
Cdd:pfam00028  80 PLSSTATVTI 89
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 26-128 1.54e-06

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 47.31  E-value: 1.54e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255133  26 PATGNVAENSPPGTSVHKFSVKlSASLSPVIPGFPQIVNSNPLtEAFRVNWLSGtyfEVVTTGmeQLDFETGPNiFDLQI 105
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSAT-DPDSGENGEVTYSIVSGNED-GLFSIDPSTG---EITTAK--PLDREEQSS-YTLTV 72

                        90       100
                ....*....|....*....|....*
gi 40255133 106 YVKDEVG--VTDLQVLTVQVTDVNE 128
Cdd:cd11304  73 TATDGGGppLSSTATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
571-679 5.27e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 39.98  E-value: 5.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255133   571 YFLALPVDLKVGTNIQNfkLTCTDLDSSPRS-FRYSIGPGNVNNHFTFSPNAGSnvtrLLLTSRFDYaggfDKIWDYKLL 649
Cdd:pfam00028   1 YSASVPENAPVGTEVLT--VTATDPDLGPNGrIFYSILGGGPGGNFRIDPDTGD----ISTTKPLDR----ESIGEYELT 70

                          90       100       110
                  ....*....|....*....|....*....|
gi 40255133   650 VYVTDDNLMSDrkkaealveTGTVTLSIKV 679
Cdd:pfam00028  71 VEATDSGGPPL---------SSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 62-130 4.72e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 36.94  E-value: 4.72e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 40255133     62 IVNSNPlTEAFRVNWLSGtyfEVVTTGmeQLDFETGPNiFDLQIYVKDEVGV--TDLQVLTVQVTDVNEPP 130
Cdd:smart00112  17 ILSGND-DGLFSIDPETG---EITTTK--PLDREEQPE-YTLTVEATDGGGPplSSTATVTITVLDVNDNA 80
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 465-561 3.55e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.61  E-value: 3.55e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255133 465 SYVFDVSERRPARTRVGQVRATDKDLPQSSLL-YSISTGGAslqyPNVFWINPKTGELQLVTKVDCETTPIYILRIQATN 543
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVtYSIVSGNE----DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|.
gi 40255133 544 NED---TSSVTVTVNILEEND 561
Cdd:cd11304  77 GGGpplSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 242-341 5.32e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 5.32e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255133 242 VYTVLEELSPGTIVANITAEDPdDEGFPSHLLYSIT--TVSKYFMINQLTGTIQVAQRIDRDagelrQNPTISLEVLVKD 319
Cdd:cd11304   3 EVSVPENAPPGTVVLTVSATDP-DSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDRE-----EQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|..
gi 40255133 320 RPYGGQENRIQITFIVEDVNDN 341
Cdd:cd11304  77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
466-557 1.52e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.41  E-value: 1.52e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255133   466 YVFDVSERRPARTRVGQVRATDKDLPQ-SSLLYSISTGGASlqypNVFWINPKTGELQLVTKVDCETTPIYILRIQATNN 544
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPnGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 40255133   545 E---DTSSVTVTVNIL 557
Cdd:pfam00028  77 GgppLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 484-564 3.60e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.53  E-value: 3.60e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255133    484 RATDKDLPQSSLL-YSISTGGAslqyPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNN---EDTSSVTVTVNILEE 559
Cdd:smart00112   1 SATDADSGENGKVtYSILSGND----DGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGggpPLSSTATVTITVLDV 76


                   ....*
gi 40255133    560 NDEKP 564
Cdd:smart00112  77 NDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 141-231 1.17e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 67.34  E-value: 1.17e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255133 141 HLYIVERANPG-FIYQVEAFDPeDTSRNIPLSYFLISPPKS--FRMSAN-GTLFSTTELDFEAgHRSFHLIVEVRDSGG- 215
Cdd:cd11304   3 EVSVPENAPPGtVVLTVSATDP-DSGENGEVTYSIVSGNEDglFSIDPStGEITTAKPLDREE-QSSYTLTVTATDGGGp 80

                        90
                ....*....|....*..
gi 40255133 216 -LKASTELQVNIVNLND 231
Cdd:cd11304  81 pLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 259-342 1.66e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 60.83  E-value: 1.66e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255133    259 TAEDPDDeGFPSHLLYSIT--TVSKYFMINQLTGTIQVAQRIDRDagelrQNPTISLEVLVKDRPYGGQENRIQITFIVE 336
Cdd:smart00112   1 SATDADS-GENGKVTYSILsgNDDGLFSIDPETGEITTTKPLDRE-----EQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ....*.
gi 40255133    337 DVNDNP 342
Cdd:smart00112  75 DVNDNA 80
Cadherin pfam00028
Cadherin domain;
241-336 6.32e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 56.54  E-value: 6.32e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255133   241 RVYTVLEELSPGTIVANITAEDPdDEGFPSHLLYSITT--VSKYFMINQLTGTIQVAQRIDRDagelrQNPTISLEVLVK 318
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDP-DLGPNGRIFYSILGggPGGNFRIDPDTGDISTTKPLDRE-----SIGEYELTVEAT 74

                          90
                  ....*....|....*...
gi 40255133   319 DRPYGGQENRIQITFIVE 336
Cdd:pfam00028  75 DSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 158-234 2.98e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 51.58  E-value: 2.98e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255133    158 AFDPeDTSRNIPLSYFLIS--PPKSFRMSAN-GTLFSTTELDFEAGHRsFHLIVEVRDSGG--LKASTELQVNIVNLNDE 232
Cdd:smart00112   2 ATDA-DSGENGKVTYSILSgnDDGLFSIDPEtGEITTTKPLDREEQPE-YTLTVEATDGGGppLSSTATVTITVLDVNDN 79


                   ..
gi 40255133    233 VP 234
Cdd:smart00112  80 AP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 570-679 4.61e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 51.55  E-value: 4.61e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255133 570 SYFLALPVDLKVGTNIqnFKLTCTDLDSSPRS-FRYSIGPGNVNNHFTFSPNAGsnvtRLLLTSRFDYaggfDKIWDYKL 648
Cdd:cd11304   1 SYEVSVPENAPPGTVV--LTVSATDPDSGENGeVTYSIVSGNEDGLFSIDPSTG----EITTAKPLDR----EEQSSYTL 70

                        90       100       110
                ....*....|....*....|....*....|.
gi 40255133 649 LVYVTDDNLMSdrkkaealvETGTVTLSIKV 679
Cdd:cd11304  71 TVTATDGGGPP---------LSSTATVTITV 92
Cadherin pfam00028
Cadherin domain;
141-226 1.20e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 50.38  E-value: 1.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255133   141 HLYIVERANPG-FIYQVEAFDPeDTSRNIPLSYFLIS--PPKSFRM-SANGTLFSTTELDFEAGhRSFHLIVEVRDSGGL 216
Cdd:pfam00028   2 SASVPENAPVGtEVLTVTATDP-DLGPNGRIFYSILGggPGGNFRIdPDTGDISTTKPLDRESI-GEYELTVEATDSGGP 79

                          90
                  ....*....|
gi 40255133   217 KASTELQVNI 226
Cdd:pfam00028  80 PLSSTATVTI 89
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 26-128 1.54e-06

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 47.31  E-value: 1.54e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255133  26 PATGNVAENSPPGTSVHKFSVKlSASLSPVIPGFPQIVNSNPLtEAFRVNWLSGtyfEVVTTGmeQLDFETGPNiFDLQI 105
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSAT-DPDSGENGEVTYSIVSGNED-GLFSIDPSTG---EITTAK--PLDREEQSS-YTLTV 72

                        90       100
                ....*....|....*....|....*
gi 40255133 106 YVKDEVG--VTDLQVLTVQVTDVNE 128
Cdd:cd11304  73 TATDGGGppLSSTATVTITVLDVND 97
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 240-319 1.07e-05

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 44.44  E-value: 1.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255133   240 TRVYTVLEELSPGTIVANITAedpdDEGFPSHLLYS--ITTVSK----YFMINQLTGTIQVAQRIDRDagEL-RQNP--T 310
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAK----DLGLEVGELAArgARVVSKgnkqYFQLNPETGDLLLNEKLDRE--ELcGSTEpcV 74


                  ....*....
gi 40255133   311 ISLEVLVKD 319
Cdd:pfam08266  75 LHFQVLLEN 83
Cadherin pfam00028
Cadherin domain;
571-679 5.27e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 39.98  E-value: 5.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255133   571 YFLALPVDLKVGTNIQNfkLTCTDLDSSPRS-FRYSIGPGNVNNHFTFSPNAGSnvtrLLLTSRFDYaggfDKIWDYKLL 649
Cdd:pfam00028   1 YSASVPENAPVGTEVLT--VTATDPDLGPNGrIFYSILGGGPGGNFRIDPDTGD----ISTTKPLDR----ESIGEYELT 70

                          90       100       110
                  ....*....|....*....|....*....|
gi 40255133   650 VYVTDDNLMSDrkkaealveTGTVTLSIKV 679
Cdd:pfam00028  71 VEATDSGGPPL---------SSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 62-130 4.72e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 36.94  E-value: 4.72e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 40255133     62 IVNSNPlTEAFRVNWLSGtyfEVVTTGmeQLDFETGPNiFDLQIYVKDEVGV--TDLQVLTVQVTDVNEPP 130
Cdd:smart00112  17 ILSGND-DGLFSIDPETG---EITTTK--PLDREEQPE-YTLTVEATDGGGPplSSTATVTITVLDVNDNA 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH