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Conserved domains on  [gi|24659480|ref|NP_729180|]
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axundead, isoform C [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BACK super family cl28903
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 252-321 3.87e-14

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


The actual alignment was detected with superfamily member cd18488:

Pssm-ID: 475122  Cd Length: 95  Bit Score: 67.78  E-value: 3.87e-14
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659480 252 QLIDMHAELQLSMPEISDLRFEELETLVKRDTLQLRsEVTLFECLATWSLAECARKHIDATPENRRTVLG 321
Cdd:cd18488  27 EVIDAQAELALKSEGFTEIDYKTLESILRRETLNAK-ESVVFEAALRWAEAECQRRGLEPTPENKRKVLG 95
 
Name Accession Description Interval E-value
BACK_BTBD3_like cd18488
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD3 and ...
 252-321 3.87e-14

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This subfamily includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionarily-conserved role during neuronal development.


Pssm-ID: 350563  Cd Length: 95  Bit Score: 67.78  E-value: 3.87e-14
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659480 252 QLIDMHAELQLSMPEISDLRFEELETLVKRDTLQLRsEVTLFECLATWSLAECARKHIDATPENRRTVLG 321
Cdd:cd18488  27 EVIDAQAELALKSEGFTEIDYKTLESILRRETLNAK-ESVVFEAALRWAEAECQRRGLEPTPENKRKVLG 95
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 246-340 2.39e-05

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 43.10  E-value: 2.39e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659480    246 LLHNTLQLIDMHAELQLSMPEISDLRFEELETLVKRDTLQLRSEVTLFECLATWslaecarkhIDATPENRRTVLGPLCL 325
Cdd:smart00875  16 LAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRW---------VKHDPEKRREHLPELLE 86

                           90
                   ....*....|....*
gi 24659480    326 TPRYLRMTASEFRRC 340
Cdd:smart00875  87 HVRLPLLSPDYLLEV 101
 
Name Accession Description Interval E-value
BACK_BTBD3_like cd18488
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD3 and ...
 252-321 3.87e-14

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This subfamily includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionarily-conserved role during neuronal development.


Pssm-ID: 350563  Cd Length: 95  Bit Score: 67.78  E-value: 3.87e-14
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659480 252 QLIDMHAELQLSMPEISDLRFEELETLVKRDTLQLRsEVTLFECLATWSLAECARKHIDATPENRRTVLG 321
Cdd:cd18488  27 EVIDAQAELALKSEGFTEIDYKTLESILRRETLNAK-ESVVFEAALRWAEAECQRRGLEPTPENKRKVLG 95
BACK_BTBD3 cd18524
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 3 (BTBD3); ...
 252-321 1.29e-12

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in mammalian neocortex.


Pssm-ID: 350599  Cd Length: 95  Bit Score: 63.59  E-value: 1.29e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659480 252 QLIDMHAELQLSMPEISDLRFEELETLVKRDTLQLRsEVTLFECLATWSLAECARKHIDATPENRRTVLG 321
Cdd:cd18524  27 EVIDAQAELALKSEGFCDIDFQTLESILRRETLNAK-EIVVFEAALNWAEVECQRQELQPTIENKRKVLG 95
BACK_BTBD6 cd18525
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 6 (BTBD6); ...
 252-321 2.34e-11

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also called lens BTB domain protein, is a BTB-domain-containing Kelch-like protein that is required for proper embryogenesis and plays an essential evolutionarily-conserved role during neuronal development.


Pssm-ID: 350600  Cd Length: 95  Bit Score: 60.10  E-value: 2.34e-11
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659480 252 QLIDMHAELQLSMPEISDLRFEELETLVKRDTLQLRsEVTLFECLATWSLAECARKHIDATPENRRTVLG 321
Cdd:cd18525  27 EVIDAQAELALKSEGFCEIDQQTLEIILTRETLNTK-EVVVFEAVLNWAEAECKRQGLPPTARNKRNVLG 95
BACK_BTBD1_like cd18487
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD1 and ...
 251-321 6.14e-11

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This subfamily includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme in cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta.


Pssm-ID: 350562  Cd Length: 95  Bit Score: 58.91  E-value: 6.14e-11
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24659480 251 LQLIDMHAELQLSMPEISDLRFEELETLVKRDTLQLRsEVTLFECLATWSLAECARKHIDATPENRRTVLG 321
Cdd:cd18487  26 LETIDKNTAEALAAEGFTDIDLDTLCVVLERDTLGIR-ECKLFQAVLRWAEAECQRQGLSVTPENQRKVLG 95
BACK_BTBD2 cd18523
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 2 (BTBD2); ...
 251-321 1.44e-09

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme in cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta.


Pssm-ID: 350598  Cd Length: 106  Bit Score: 55.38  E-value: 1.44e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24659480 251 LQLIDMHAELQLSMPEISDLRFEELETLVKRDTLQLRsEVTLFECLATWSLAECARKHIDATPENRRTVLG 321
Cdd:cd18523  26 LENIDKNTSDAINAEGFTDIDLDTLVAVLERDTLGIR-EVRLFNAVVRWAEAECQRQQLQVTPENKRKVLG 95
BACK_BTBD1 cd18522
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 1 (BTBD1); ...
 251-333 6.91e-07

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein specifically expressed in skeletal muscle. It interacts with DNA topoisomerase 1 (Topo1), a key enzyme in cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. It may serve as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.


Pssm-ID: 350597  Cd Length: 107  Bit Score: 47.75  E-value: 6.91e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659480 251 LQLIDMHAELQLSMPEISDLRFEELETLVKRDTLQLRsEVTLFECLATWSLAECARKHIDATPENRRTVLGPLCLTPRYL 330
Cdd:cd18522  26 LDTIDKSTMDAISAEGFTDIDLDTLCAVLERDTLSIR-ESRLFGAVVRWAEAECQRQQLPVTSENKQKVLGKALSLIRFP 104


                ...
gi 24659480 331 RMT 333
Cdd:cd18522 105 LMT 107
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 246-340 2.39e-05

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 43.10  E-value: 2.39e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659480    246 LLHNTLQLIDMHAELQLSMPEISDLRFEELETLVKRDTLQLRSEVTLFECLATWslaecarkhIDATPENRRTVLGPLCL 325
Cdd:smart00875  16 LAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRW---------VKHDPEKRREHLPELLE 86

                           90
                   ....*....|....*
gi 24659480    326 TPRYLRMTASEFRRC 340
Cdd:smart00875  87 HVRLPLLSPDYLLEV 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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