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Conserved domains on  [gi|29337283|ref|NP_803429|]
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ly-6/neurotoxin-like protein 1 precursor [Homo sapiens]

Protein Classification

Ly-6/uPAR domain-containing protein( domain architecture ID 10061478)

LU (Ly-6 antigen/uPA receptor-like) domain-containing protein similar to GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_LYNX1 cd23585
extracellular domain (ECD) found in Ly-6/neurotoxin-like protein 1 (LYNX1) and similar protein; ...
 20-93 3.76e-42

extracellular domain (ECD) found in Ly-6/neurotoxin-like protein 1 (LYNX1) and similar protein; LYNX1 (also called testicular tissue protein Li 112) is an endogenous prototoxin that acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). It prevents plasticity in the primary visual cortex late in life. LYNX1 contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


:

Pssm-ID: 467115  Cd Length: 74  Bit Score: 133.20  E-value: 3.76e-42
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 29337283  20 ALDCHVCAYNGDNCFNPMRCPAMVAYCMTTRTYYTPTRMKVSKSCVPRCFETVYDGYSKHASTTSCCQYDLCNG 93
Cdd:cd23585   1 ALDCHVCAYNGDNCFNPMRCPAMVAYCMTTRTYYTPTRMKVSKSCVPRCFETVYDGYSKHASTTSCCQYDLCNG 74
 
Name Accession Description Interval E-value
TFP_LU_ECD_LYNX1 cd23585
extracellular domain (ECD) found in Ly-6/neurotoxin-like protein 1 (LYNX1) and similar protein; ...
 20-93 3.76e-42

extracellular domain (ECD) found in Ly-6/neurotoxin-like protein 1 (LYNX1) and similar protein; LYNX1 (also called testicular tissue protein Li 112) is an endogenous prototoxin that acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). It prevents plasticity in the primary visual cortex late in life. LYNX1 contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467115  Cd Length: 74  Bit Score: 133.20  E-value: 3.76e-42
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 29337283  20 ALDCHVCAYNGDNCFNPMRCPAMVAYCMTTRTYYTPTRMKVSKSCVPRCFETVYDGYSKHASTTSCCQYDLCNG 93
Cdd:cd23585   1 ALDCHVCAYNGDNCFNPMRCPAMVAYCMTTRTYYTPTRMKVSKSCVPRCFETVYDGYSKHASTTSCCQYDLCNG 74
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 21-92 4.50e-03

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 33.66  E-value: 4.50e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 29337283     21 LDCHVCAYNGD-NCFNPMRCPAMVAYCMTTRTYYTPTR--MKVSKSC--VPRC-FETVYDGYSKHAS-TTSCCQYDLCN 92
Cdd:smart00134   1 LQCYSCTGNPDsSCSSEEECRSPDDVCLTVVAEVISDSrgSVVYKGCatSPICpGSHGYEINLTIAFlKVSCCQTDLCN 79
 
Name Accession Description Interval E-value
TFP_LU_ECD_LYNX1 cd23585
extracellular domain (ECD) found in Ly-6/neurotoxin-like protein 1 (LYNX1) and similar protein; ...
 20-93 3.76e-42

extracellular domain (ECD) found in Ly-6/neurotoxin-like protein 1 (LYNX1) and similar protein; LYNX1 (also called testicular tissue protein Li 112) is an endogenous prototoxin that acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). It prevents plasticity in the primary visual cortex late in life. LYNX1 contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467115  Cd Length: 74  Bit Score: 133.20  E-value: 3.76e-42
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 29337283  20 ALDCHVCAYNGDNCFNPMRCPAMVAYCMTTRTYYTPTRMKVSKSCVPRCFETVYDGYSKHASTTSCCQYDLCNG 93
Cdd:cd23585   1 ALDCHVCAYNGDNCFNPMRCPAMVAYCMTTRTYYTPTRMKVSKSCVPRCFETVYDGYSKHASTTSCCQYDLCNG 74
TFP_LU_ECD_Ly6D cd23542
extracellular domain (ECD) found in lymphocyte antigen 6D (Ly-6D) and similar proteins; Ly-6D ...
 16-93 1.10e-08

extracellular domain (ECD) found in lymphocyte antigen 6D (Ly-6D) and similar proteins; Ly-6D (also called E48 antigen) is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion. It may act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Ly-6D contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467072  Cd Length: 79  Bit Score: 48.18  E-value: 1.10e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 29337283  16 PLAQALDCHVCAYNgDNCFNPMRCPAMVAYCMTTRTYYTPTRMkVSKSCVPRCFETVYD-GYSKHASTTSCCQYDLCNG 93
Cdd:cd23542   1 GPANALQCHVCNSS-SNCTNPVNCEGSERYCKTTTVVQPSGNL-VKKGCAETCPPSTSRqQVGSGISSVTCCQGDLCNS 77
TFP_LU_ECD_Ly6M cd23552
extracellular domain (ECD) found in Mus musculus Ly-6 family protein Ly-6M and similar ...
 17-94 3.63e-08

extracellular domain (ECD) found in Mus musculus Ly-6 family protein Ly-6M and similar proteins; Ly-6M is a novel member of the Ly-6 family of hematopoietic proteins. It contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467082  Cd Length: 80  Bit Score: 46.78  E-value: 3.63e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 29337283  17 LAQALDCHVCAYNGDnCFNPMRCPAMVAYCMTTRTYYTPTRMKVSKSCVPRCFETvydGYSKHASTTSCCQYDLCNGT 94
Cdd:cd23552   3 SAQALKCHECKGIED-CYNPTSCNNQSRYCLTTWYTPPGEKTTVTKSCAYTCPDA---PESLANSKASCCNTDLCNSA 76
TFP_LU_ECD_Ly6E cd23543
extracellular domain (ECD) found in lymphocyte antigen 6E (Ly-6E) and similar proteins; Ly-6E ...
 20-92 3.90e-06

extracellular domain (ECD) found in lymphocyte antigen 6E (Ly-6E) and similar proteins; Ly-6E (also called retinoic acid-induced gene E protein (RIG-E), or stem cell antigen 2 (SCA-2), or thymic shared antigen 1 (TSA-1)) is a GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. It restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion. It plays an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). It may also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. Ly-6E contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467073  Cd Length: 78  Bit Score: 41.57  E-value: 3.90e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 29337283  20 ALDCHVC--AYNGDNCFNPMRCPAMVAYCM---TTRTYYTPTRMKVSKSCVPRCFETVYDgYSKHASTTSCCQYDLCN 92
Cdd:cd23543   2 SLYCYTCenQSSNWNCLKPTKCSDNDKYCVttvASGGTGSSSGVRITKKCSPKCPETNVN-IGIASVSTSCCQSSLCN 78
TFP_LU_ECD_GPIHBP1 cd23575
extracellular domain (ECD) found in glycosylphosphatidylinositol-anchored high density ...
 20-95 9.94e-06

extracellular domain (ECD) found in glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPI-HBP1) and similar proteins; GPI-HBP1 (also called GPI-anchored HDL-binding protein 1, or high density lipoprotein-binding protein 1) is an endothelial cell transporter for lipoprotein lipase. It mediates the transport of lipoprotein lipase LPL from the basolateral to the apical surface of endothelial cells in capillaries and anchors LPL on the surface of endothelial cells in the lumen of blood capillaries. GPI-HBP1 protects LPL against loss of activity, and against ANGPTL4-mediated unfolding. Thereby, it plays an important role in lipolytic processing of chylomicrons by LPL, triglyceride metabolism and lipid homeostasis. GPI-HBP1 binds chylomicrons and phospholipid particles that contain APOA5. It also binds high-density lipoprotein (HDL) and plays a role in the uptake of lipids from HDL. GPI-HBP1 contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467105  Cd Length: 83  Bit Score: 40.78  E-value: 9.94e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29337283  20 ALDCHVC--AYNGDNCFNPMRCPAMVAYCMTTRTYYTPTRMK---VSKSCVPRCFETVYDgYSKHASTTSCCQYDLCNGT 94
Cdd:cd23575   2 SLKCYTCvsAHSNSDCLTETNCSSSDTYCKTLVASASGGSGSlttITKWCASSCTPSTRT-VEGTKVTVSCCQTDLCNVS 80


                .
gi 29337283  95 G 95
Cdd:cd23575  81 G 81
TFP_LU_ECD_Ly6K cd23550
extracellular domain (ECD) found in lymphocyte antigen 6K (Ly-6K) and similar proteins; Ly-6K ...
 21-95 7.27e-05

extracellular domain (ECD) found in lymphocyte antigen 6K (Ly-6K) and similar proteins; Ly-6K is required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida. It may play a role in cell growth. Ly-6K contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467080  Cd Length: 86  Bit Score: 38.45  E-value: 7.27e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29337283  21 LDCHVC-AYNGDNCFNPMRCPAMVAYCMTTRTYYTPTRMKVSKSCVPRCFETVYDGYSKHAST---------TSCCQYDL 90
Cdd:cd23550   1 LTCHVCeVENSFNCTNPVTCTWEETYCVLAAVRIFPRFFLVSKQCSKYCPVVEVPPPPPKSFVlekpmpflyIKCCRENL 80


                ....*
gi 29337283  91 CNGTG 95
Cdd:cd23550  81 CNEEG 85
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 21-92 4.50e-03

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 33.66  E-value: 4.50e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 29337283     21 LDCHVCAYNGD-NCFNPMRCPAMVAYCMTTRTYYTPTR--MKVSKSC--VPRC-FETVYDGYSKHAS-TTSCCQYDLCN 92
Cdd:smart00134   1 LQCYSCTGNPDsSCSSEEECRSPDDVCLTVVAEVISDSrgSVVYKGCatSPICpGSHGYEINLTIAFlKVSCCQTDLCN 79
TFP cd00117
three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU ...
 21-92 5.04e-03

three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU (also known as Ly-6 antigen/uPA receptor)-like extracellular domain (ECD) occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. It is a structural domain involved in protein-protein interactions, tolerating an unusual degree of variation and binding with high specificity to a broad spectrum of targets. The snake toxin domain is present in short and long neurotoxins, cytotoxins, and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. Both the LU-like ECD and the snake toxin domain belong to three-fingered protein (TFP) fold, which is characterized by containing 70 to 100 amino acids including eight to ten cysteine residues spaced at conserved distances.


Pssm-ID: 467060  Cd Length: 81  Bit Score: 33.61  E-value: 5.04e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29337283  21 LDCHVCAYNGDNCF-----NPMRCPAMVAYCMTTRTYYTPTRMKVSKSCVPRCF----ETVYDGYSKHASTTSCCQYDLC 91
Cdd:cd00117   1 LKCYQCNSSNDPNCcnsspTLVTCSSPETFCRKIVGKVGGGETLVIRGCATECEcgctECCSGTGTSGTTCTSCCDTDLC 80


                .
gi 29337283  92 N 92
Cdd:cd00117  81 N 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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