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Conserved domains on  [gi|282721066|ref|NP_808344|]
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IQ and AAA domain-containing protein 1-like [Mus musculus]

Protein Classification

P-loop NTPase family protein( domain architecture ID 1562424)

P-loop NTPase (nucleoside triphosphate hydrolase) family protein contains two conserved sequence signatures, the Walker A motif (the P-loop proper) and Walker B motif which bind, respectively, the beta and gamma phosphate moieties of the bound nucleotide (typically ATP or GTP), and a Mg(2+) cation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
 540-699 1.98e-77

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member cd19506:

Pssm-ID: 476819 [Multi-domain]  Cd Length: 160  Bit Score: 247.44  E-value: 1.98e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721066 540 DIRQNMALYGVLRLGSHDIHTMAPLVRSILLVGPSGMGKKMLVQAVCTETGANLFDLSPDNLMGKYPGKNGAQLLVHIVF 619
Cdd:cd19506    1 DVRQLLTLYGILPLGSQAVHEKAPLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSPSNIAGKYPGKNGLQMMLHLVL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721066 620 KVARLLQPSVIWIGNTEKTFYKKVPKEERTMDPKRIKKDLMRATKQLSPGDRVMLIGTTERPQLAEMKGLCRFYERILFI 699
Cdd:cd19506   81 KVARQLQPSVIWIGDAEKTFYKKVPKTEKQLDPKRLKKDLPKILKSLKPEDRVLIVGTTSRPFEADLKSFCKVYNKIILI 160
 
Name Accession Description Interval E-value
RecA-like_IQCA1 cd19506
ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein ...
 540-699 1.98e-77

ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein regulatory complex subunit 11, DRC11 and IQCA) is an ATPase subunit of the nexin-dynein regulatory complex (N-DRC). The 9 + 2 axoneme of most motile cilia and flagella consists of nine outer doublet microtubules arranged in a ring surrounding a central pair of two singlet microtubules. The N-DRC complex maintains alignment between outer doublet microtubules and limits microtubule sliding in motile axonemes. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410914 [Multi-domain]  Cd Length: 160  Bit Score: 247.44  E-value: 1.98e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721066 540 DIRQNMALYGVLRLGSHDIHTMAPLVRSILLVGPSGMGKKMLVQAVCTETGANLFDLSPDNLMGKYPGKNGAQLLVHIVF 619
Cdd:cd19506    1 DVRQLLTLYGILPLGSQAVHEKAPLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSPSNIAGKYPGKNGLQMMLHLVL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721066 620 KVARLLQPSVIWIGNTEKTFYKKVPKEERTMDPKRIKKDLMRATKQLSPGDRVMLIGTTERPQLAEMKGLCRFYERILFI 699
Cdd:cd19506   81 KVARQLQPSVIWIGDAEKTFYKKVPKTEKQLDPKRLKKDLPKILKSLKPEDRVLIVGTTSRPFEADLKSFCKVYNKIILI 160
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 563-764 6.90e-16

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 80.73  E-value: 6.90e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721066 563 PLVRSILLVGPSGMGKKMLVQAVCTETGANLFDLSPDNLMGKYPG---KNgaqllVHIVFKVARLLQPSVIWIgnTEktF 639
Cdd:COG0464  189 PPPRGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSDLVSKYVGeteKN-----LREVFDKARGLAPCVLFI--DE--A 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721066 640 YKKVPKEERTMDpkrikKDLMRATKQL-----SPGDRVMLIGTTERPQL--AEMkgLCRFyERILFIPRPDYASRYVLWK 712
Cdd:COG0464  260 DALAGKRGEVGD-----GVGRRVVNTLltemeELRSDVVVIAATNRPDLldPAL--LRRF-DEIIFFPLPDAEERLEIFR 331

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 282721066 713 RMIesqgRGVQLTSSLDVSALARVSDGYTPSHI-----------LQSIQSVLTERRLLQLIKK 764
Cdd:COG0464  332 IHL----RKRPLDEDVDLEELAEATEGLSGADIrnvvrraalqaLRLGREPVTTEDLLEALER 390
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 568-701 3.46e-14

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 69.93  E-value: 3.46e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721066  568 ILLVGPSGMGKKMLVQAVCTETGANLFDLSPDNLMGKYPGKNGAqlLVHIVFKVARLLQPSVIWIgnTEktFYKKVPKEE 647
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEK--RLRELFEAAKKLAPCVIFI--DE--IDALAGSRG 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 282721066  648 RTMDP--KRIKKDLMRATKQL-SPGDRVMLIGTTERPQL--AEMKGlcRFyERILFIPR 701
Cdd:pfam00004  75 SGGDSesRRVVNQLLTELDGFtSSNSKVIVIAATNRPDKldPALLG--RF-DRIIEFPL 130
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 566-818 7.34e-14

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 75.71  E-value: 7.34e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721066  566 RSILLVGPSGMGKKMLVQAVCTETGANLFDLSPDNLMGKYPGKngAQLLVHIVFKVARLLQPSVIWIGNTEKTfykkVPK 645
Cdd:TIGR01243 488 KGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKWVGE--SEKAIREIFRKARQAAPAIIFFDEIDAI----APA 561

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721066  646 EERTMDPK---RIKKDLMRATKQLSPGDRVMLIGTTERPQLAEmKGLCR--FYERILFIPRPDYASRYVLWKrmieSQGR 720
Cdd:TIGR01243 562 RGARFDTSvtdRIVNQLLTEMDGIQELSNVVVIAATNRPDILD-PALLRpgRFDRLILVPPPDEEARKEIFK----IHTR 636

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721066  721 GVQLTSSLDVSALARVSDGYTPSHILQSIQ--SVLTERRLLQLIKKPLVASEFVGHLARLDPVYREEEESLKEwfFKTPL 798
Cdd:TIGR01243 637 SMPLAEDVDLEELAEMTEGYTGADIEAVCReaAMAALRESIGSPAKEKLEVGEEEFLKDLKVEMRHFLEALKK--VKPSV 714

                         250       260
                  ....*....|....*....|
gi 282721066  799 GKKNMKFTKdQLEAEEARLT 818
Cdd:TIGR01243 715 SKEDMLRYE-RLAKELKRLT 733
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 568-741 2.43e-07

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 53.68  E-value: 2.43e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721066 568 ILLVGPSGMGKKMLVQAVCTETGANLFDLSPDNLMGKYPGKnGAQlLVHIVFKVARLLQPSVIWIGNTEKTFYKKVpkEE 647
Cdd:PRK03992 168 VLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQKFIGE-GAR-LVRELFELAREKAPSIIFIDEIDAIAAKRT--DS 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721066 648 RTMDPKRIKKDLMratkQL-------SPGDRVMLIGTTERPQLAEMKGL--CRFyERILFIPRPDYASRYVLWKrmIESq 718
Cdd:PRK03992 244 GTSGDREVQRTLM----QLlaemdgfDPRGNVKIIAATNRIDILDPAILrpGRF-DRIIEVPLPDEEGRLEILK--IHT- 315

                        170       180
                 ....*....|....*....|...
gi 282721066 719 gRGVQLTSSLDVSALARVSDGYT 741
Cdd:PRK03992 316 -RKMNLADDVDLEELAELTEGAS 337
 
Name Accession Description Interval E-value
RecA-like_IQCA1 cd19506
ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein ...
 540-699 1.98e-77

ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein regulatory complex subunit 11, DRC11 and IQCA) is an ATPase subunit of the nexin-dynein regulatory complex (N-DRC). The 9 + 2 axoneme of most motile cilia and flagella consists of nine outer doublet microtubules arranged in a ring surrounding a central pair of two singlet microtubules. The N-DRC complex maintains alignment between outer doublet microtubules and limits microtubule sliding in motile axonemes. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410914 [Multi-domain]  Cd Length: 160  Bit Score: 247.44  E-value: 1.98e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721066 540 DIRQNMALYGVLRLGSHDIHTMAPLVRSILLVGPSGMGKKMLVQAVCTETGANLFDLSPDNLMGKYPGKNGAQLLVHIVF 619
Cdd:cd19506    1 DVRQLLTLYGILPLGSQAVHEKAPLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSPSNIAGKYPGKNGLQMMLHLVL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721066 620 KVARLLQPSVIWIGNTEKTFYKKVPKEERTMDPKRIKKDLMRATKQLSPGDRVMLIGTTERPQLAEMKGLCRFYERILFI 699
Cdd:cd19506   81 KVARQLQPSVIWIGDAEKTFYKKVPKTEKQLDPKRLKKDLPKILKSLKPEDRVLIVGTTSRPFEADLKSFCKVYNKIILI 160
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 564-697 9.90e-18

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 81.24  E-value: 9.90e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721066 564 LVRSILLVGPSGMGKKMLVQAVCTETGANLFDLSPDNLMGKYPGKngAQLLVHIVFKVARLLQPSVIWIGNTEKTFYKKV 643
Cdd:cd19509   31 PPRGILLYGPPGTGKTLLARAVASESGSTFFSISASSLVSKWVGE--SEKIVRALFALARELQPSIIFIDEIDSLLSERG 108

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 282721066 644 PKEERTmdPKRIKKDLMratKQL-----SPGDRVMLIGTTERPQLAEMKGLCRFYERIL 697
Cdd:cd19509  109 SGEHEA--SRRVKTEFL---VQMdgvlnKPEDRVLVLGATNRPWELDEAFLRRFEKRIY 162
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 563-698 3.78e-17

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 79.25  E-value: 3.78e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721066 563 PLVRSILLVGPSGMGKKMLVQAVCTETGANLFDLSPDNLMGKYPGKNGAqlLVHIVFKVARLLQPSVIWIGNTEKTFYKk 642
Cdd:cd19481   24 GLPKGILLYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLSKYVGESEK--NLRKIFERARRLAPCILFIDEIDAIGRK- 100

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 282721066 643 vpkeertMDPKRIKKDLMRATKQL-------SPGDRVMLIGTTERPQL--AEMKGLCRFYERILF 698
Cdd:cd19481  101 -------RDSSGESGELRRVLNQLlteldgvNSRSKVLVIAATNRPDLldPALLRPGRFDEVIEF 158
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
 566-696 2.43e-16

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 77.20  E-value: 2.43e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721066 566 RSILLVGPSGMGKKMLVQAVCTETGANLFDLSPDNLMGKYPGKngAQLLVHIVFKVARLLQPSVIWIGNTEKTFYKKVPK 645
Cdd:cd19524   34 RGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGE--GEKLVRALFAVARELQPSIIFIDEVDSLLSERSEG 111

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 282721066 646 EERTmdPKRIKKDLMRATK--QLSPGDRVMLIGTTERPQLAEMKGLCRFYERI 696
Cdd:cd19524  112 EHEA--SRRLKTEFLIEFDgvQSNGDDRVLVMGATNRPQELDDAVLRRFTKRV 162
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 563-764 6.90e-16

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 80.73  E-value: 6.90e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721066 563 PLVRSILLVGPSGMGKKMLVQAVCTETGANLFDLSPDNLMGKYPG---KNgaqllVHIVFKVARLLQPSVIWIgnTEktF 639
Cdd:COG0464  189 PPPRGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSDLVSKYVGeteKN-----LREVFDKARGLAPCVLFI--DE--A 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721066 640 YKKVPKEERTMDpkrikKDLMRATKQL-----SPGDRVMLIGTTERPQL--AEMkgLCRFyERILFIPRPDYASRYVLWK 712
Cdd:COG0464  260 DALAGKRGEVGD-----GVGRRVVNTLltemeELRSDVVVIAATNRPDLldPAL--LRRF-DEIIFFPLPDAEERLEIFR 331

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 282721066 713 RMIesqgRGVQLTSSLDVSALARVSDGYTPSHI-----------LQSIQSVLTERRLLQLIKK 764
Cdd:COG0464  332 IHL----RKRPLDEDVDLEELAEATEGLSGADIrnvvrraalqaLRLGREPVTTEDLLEALER 390
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 566-682 1.27e-15

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 75.15  E-value: 1.27e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721066 566 RSILLVGPSGMGKKMLVQAVCTETGANLFDLSPDNLMGKYPGKngAQLLVHIVFKVARLLQPSVIWIGNTEKTFYKKVPK 645
Cdd:cd19520   36 KGVLLYGPPGCGKTMLAKATAKEAGARFINLQVSSLTDKWYGE--SQKLVAAVFSLASKLQPSIIFIDEIDSFLRQRSST 113

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 282721066 646 EERTMdpKRIKKDLMRATKQLS--PGDRVMLIGTTERPQ 682
Cdd:cd19520  114 DHEAT--AMMKAEFMSLWDGLStdGNCRVIVMGATNRPQ 150
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
 566-696 2.99e-15

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 74.64  E-value: 2.99e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721066 566 RSILLVGPSGMGKKMLVQAVCTETGANLFDLSPDNLMGKYPGKngAQLLVHIVFKVARLLQPSVIWIGNTEKTFYKKVPK 645
Cdd:cd19525   56 KGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKWVGE--GEKMVRALFSVARCKQPAVIFIDEIDSLLSQRGEG 133

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 282721066 646 EERTmdPKRIKKDLMRATK--QLSPGDRVMLIGTTERPQLAEMKGLCRFYERI 696
Cdd:cd19525  134 EHES--SRRIKTEFLVQLDgaTTSSEDRILVVGATNRPQEIDEAARRRLVKRL 184
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 568-701 3.46e-14

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 69.93  E-value: 3.46e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721066  568 ILLVGPSGMGKKMLVQAVCTETGANLFDLSPDNLMGKYPGKNGAqlLVHIVFKVARLLQPSVIWIgnTEktFYKKVPKEE 647
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEK--RLRELFEAAKKLAPCVIFI--DE--IDALAGSRG 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 282721066  648 RTMDP--KRIKKDLMRATKQL-SPGDRVMLIGTTERPQL--AEMKGlcRFyERILFIPR 701
Cdd:pfam00004  75 SGGDSesRRVVNQLLTELDGFtSSNSKVIVIAATNRPDKldPALLG--RF-DRIIEFPL 130
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 566-818 7.34e-14

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 75.71  E-value: 7.34e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721066  566 RSILLVGPSGMGKKMLVQAVCTETGANLFDLSPDNLMGKYPGKngAQLLVHIVFKVARLLQPSVIWIGNTEKTfykkVPK 645
Cdd:TIGR01243 488 KGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKWVGE--SEKAIREIFRKARQAAPAIIFFDEIDAI----APA 561

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721066  646 EERTMDPK---RIKKDLMRATKQLSPGDRVMLIGTTERPQLAEmKGLCR--FYERILFIPRPDYASRYVLWKrmieSQGR 720
Cdd:TIGR01243 562 RGARFDTSvtdRIVNQLLTEMDGIQELSNVVVIAATNRPDILD-PALLRpgRFDRLILVPPPDEEARKEIFK----IHTR 636

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721066  721 GVQLTSSLDVSALARVSDGYTPSHILQSIQ--SVLTERRLLQLIKKPLVASEFVGHLARLDPVYREEEESLKEwfFKTPL 798
Cdd:TIGR01243 637 SMPLAEDVDLEELAEMTEGYTGADIEAVCReaAMAALRESIGSPAKEKLEVGEEEFLKDLKVEMRHFLEALKK--VKPSV 714

                         250       260
                  ....*....|....*....|
gi 282721066  799 GKKNMKFTKdQLEAEEARLT 818
Cdd:TIGR01243 715 SKEDMLRYE-RLAKELKRLT 733
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 565-681 7.24e-13

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 67.32  E-value: 7.24e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721066 565 VRSILLVGPSGMGKKMLVQAVCTETGANLFDLSPDNLMGKYPGKNGAQLlvHIVFKVARLLQPSVIWIGNTEKTfykkVP 644
Cdd:cd19503   34 PRGVLLHGPPGTGKTLLARAVANEAGANFLSISGPSIVSKYLGESEKNL--REIFEEARSHAPSIIFIDEIDAL----AP 107

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 282721066 645 KEE---RTMDpKRIKKDLMRATKQLSPGDRVMLIGTTERP 681
Cdd:cd19503  108 KREedqREVE-RRVVAQLLTLMDGMSSRGKVVVIAATNRP 146
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
 561-697 3.36e-12

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 65.29  E-value: 3.36e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721066 561 MAPLVRSILLVGPSGMGKKMLVQAVCTETGANLFDLSPDNLMGKYPGKngAQLLVHIVFKVARLLQPSVIWIGNTEKTFY 640
Cdd:cd19523   29 LLRLPRSILLFGPRGTGKTLLGRCLASQLGATFLRLRGSTLVAKWAGE--GEKILQASFLAARCRQPSVLFISDLDALLS 106

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 282721066 641 KKVPKEERTmdpKRIKKDLMratKQL-----SPGDRVMLIGTTERPQLAEMKGLCRFYERIL 697
Cdd:cd19523  107 SQDDEASPV---GRLQVELL---AQLdgvlgSGEDGVLVVCTTSKPEEIDESLRRYFSKRLL 162
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 566-741 1.60e-10

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 64.93  E-value: 1.60e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721066  566 RSILLVGPSGMGKKMLVQAVCTETGANLFDLSPDNLMGKYPGKNGAQLlvHIVFKVARLLQPSVIWIGNTEKTfykkVPK 645
Cdd:TIGR01243 213 KGVLLYGPPGTGKTLLAKAVANEAGAYFISINGPEIMSKYYGESEERL--REIFKEAEENAPSIIFIDEIDAI----APK 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721066  646 EERTMD--PKRIKKDLMRATKQLSPGDRVMLIGTTERPQLAE--MKGLCRFyERILFIPRPDYASRyvlwKRMIESQGRG 721
Cdd:TIGR01243 287 REEVTGevEKRVVAQLLTLMDGLKGRGRVIVIGATNRPDALDpaLRRPGRF-DREIVIRVPDKRAR----KEILKVHTRN 361

                         170       180
                  ....*....|....*....|
gi 282721066  722 VQLTSSLDVSALARVSDGYT 741
Cdd:TIGR01243 362 MPLAEDVDLDKLAEVTHGFV 381
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
 566-696 2.20e-10

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 60.26  E-value: 2.20e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721066 566 RSILLVGPSGMGKKMLVQAVCTETGANLFDLSPDNLMGKYPGKngAQLLVHIVFKVARLLQPSVIWIGNTEKTFYKKVPK 645
Cdd:cd19521   41 SGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSKWMGE--SEKLVKQLFAMARENKPSIIFIDEVDSLCGTRGEG 118

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 282721066 646 EERTMdpKRIKKDLMRATKQL-SPGDRVMLIGTTERPQLAEMKGLCRFYERI 696
Cdd:cd19521  119 ESEAS--RRIKTELLVQMNGVgNDSQGVLVLGATNIPWQLDSAIRRRFEKRI 168
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
 566-683 1.75e-09

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 57.51  E-value: 1.75e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721066 566 RSILLVGPSGMGKKMLVQAVCTETGANLFDLSPDNLMGKYPGKngAQLLVHIVFKVARLLQPSVIWIGNTEKTfykkVPK 645
Cdd:cd19529   28 KGILLYGPPGTGKTLLAKAVATESNANFISVKGPELLSKWVGE--SEKAIREIFRKARQVAPCVIFFDEIDSI----APR 101

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 282721066 646 EERTMD---PKRIKKDLMRATKQLSPGDRVMLIGTTERPQL 683
Cdd:cd19529  102 RGTTGDsgvTERVVNQLLTELDGLEEMNGVVVIAATNRPDI 142
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
 566-681 3.49e-09

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 56.68  E-value: 3.49e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721066 566 RSILLVGPSGMGKKMLVQAVCTETGANLFDLSPDNLMGKYPGKNGAQLlvHIVFKVARLLQPSVIWIGNTEKTfykkVPK 645
Cdd:cd19519   35 RGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNL--RKAFEEAEKNAPAIIFIDEIDAI----APK 108

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 282721066 646 EERTMD--PKRIKKDLMRATKQLSPGDRVMLIGTTERP 681
Cdd:cd19519  109 REKTHGevERRIVSQLLTLMDGLKQRAHVIVMAATNRP 146
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 568-681 1.05e-07

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 52.11  E-value: 1.05e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721066 568 ILLVGPSGMGKKMLVQAVCTETGANLFDLSPDNLMGKYPGKngAQLLVHIVFKVARLLQPSVIWIGNTEKTfykkVPK-- 645
Cdd:cd19530   33 VLLYGPPGCGKTLLAKAVANESGANFISVKGPELLNKYVGE--SERAVRQVFQRARASAPCVIFFDEVDAL----VPKrg 106

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 282721066 646 EERTMDPKRIKKDLMRATKQLSPGDRVMLIGTTERP 681
Cdd:cd19530  107 DGGSWASERVVNQLLTEMDGLEERSNVFVIAATNRP 142
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
 566-683 1.44e-07

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 51.90  E-value: 1.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721066 566 RSILLVGPSGMGKKMLVQAVCTETGANLFDLSPDNLMGKYPGKngAQLLVHIVFKVARLLQPSVIWIGNTEkTFYKKVPK 645
Cdd:cd19511   28 KGVLLYGPPGCGKTLLAKALASEAGLNFISVKGPELFSKYVGE--SERAVREIFQKARQAAPCIIFFDEID-SLAPRRGQ 104

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 282721066 646 EERTMDPKRIKKDLMRATKQLSPGDRVMLIGTTERPQL 683
Cdd:cd19511  105 SDSSGVTDRVVSQLLTELDGIESLKGVVVIAATNRPDM 142
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 568-741 2.43e-07

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 53.68  E-value: 2.43e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721066 568 ILLVGPSGMGKKMLVQAVCTETGANLFDLSPDNLMGKYPGKnGAQlLVHIVFKVARLLQPSVIWIGNTEKTFYKKVpkEE 647
Cdd:PRK03992 168 VLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQKFIGE-GAR-LVRELFELAREKAPSIIFIDEIDAIAAKRT--DS 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721066 648 RTMDPKRIKKDLMratkQL-------SPGDRVMLIGTTERPQLAEMKGL--CRFyERILFIPRPDYASRYVLWKrmIESq 718
Cdd:PRK03992 244 GTSGDREVQRTLM----QLlaemdgfDPRGNVKIIAATNRIDILDPAILrpGRF-DRIIEVPLPDEEGRLEILK--IHT- 315

                        170       180
                 ....*....|....*....|...
gi 282721066 719 gRGVQLTSSLDVSALARVSDGYT 741
Cdd:PRK03992 316 -RKMNLADDVDLEELAELTEGAS 337
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 566-681 1.22e-06

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 49.33  E-value: 1.22e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721066 566 RSILLVGPSGMGKKMLVQAVCTETGANLFDLSPDNLMGKYPGKNGAQllVHIVFKVARLLQPSVIWIGNTEKTfykkVPK 645
Cdd:cd19518   35 RGVLLHGPPGCGKTMLANAIAGELKVPFLKISATEIVSGVSGESEEK--IRELFDQAISNAPCIVFIDEIDAI----TPK 108

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 282721066 646 EE---RTMDpKRIKKDLMRATKQL----SPGDRVMLIGTTERP 681
Cdd:cd19518  109 REsaqREME-RRIVSQLLTCMDELnnekTAGGPVLVIGATNRP 150
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
 568-683 3.72e-06

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 47.89  E-value: 3.72e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721066 568 ILLVGPSGMGKKMLVQAVCTETGANLFDLSPDNLMGKYPGKNGAQllVHIVFKVARLLQPSVIWIGNTEKTfykkVPKEE 647
Cdd:cd19527   29 ILLYGPPGTGKTLLAKAIATECSLNFLSVKGPELINMYIGESEAN--VREVFQKARDAKPCVIFFDELDSL----APSRG 102

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 282721066 648 RTMDP----KRIKKDLMRATKQLSP-GDRVMLIGTTERPQL 683
Cdd:cd19527  103 NSGDSggvmDRVVSQLLAELDGMSSsGQDVFVIGATNRPDL 143
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 566-700 8.89e-05

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 43.67  E-value: 8.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721066 566 RSILLVGPSGMGKKMLVQAVCTET---GANLFDLSPDNLMGKYPGKNGAQL-LVHIVFKVARLLQPSVIWIGNTEKTFYK 641
Cdd:cd00009   20 KNLLLYGPPGTGKTTLARAIANELfrpGAPFLYLNASDLLEGLVVAELFGHfLVRLLFELAEKAKPGVLFIDEIDSLSRG 99

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 282721066 642 KVPKEERTMDpkrikkDLMRATKQLspgDRVMLIGTTERPQLAEMKGLC--RFYERILFIP 700
Cdd:cd00009  100 AQNALLRVLE------TLNDLRIDR---ENVRVIGATNRPLLGDLDRALydRLDIRIVIPL 151
RecA-like_Ycf46-like cd19507
ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of ...
 562-639 9.59e-05

ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of photosynthesis in cyanobacteria, especially in CO2 uptake and utilization. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410915 [Multi-domain]  Cd Length: 161  Bit Score: 43.51  E-value: 9.59e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 282721066 562 APLVRSILLVGPSGMGKKMLVQAVCTETGANLFDLSPDNLMGKYPGKNGAQLlvHIVFKVARLLQPSVIWIGNTEKTF 639
Cdd:cd19507   28 LPTPKGLLLVGIQGTGKSLTAKAIAGVWQLPLLRLDMGRLFGGLVGESESRL--RQMIQTAEAIAPCVLWIDEIEKGF 103
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
 563-683 4.74e-04

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 41.65  E-value: 4.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721066 563 PLVRSILLVGPSGMGKKMLVQAVCTETGANLFDLSPDNLMGKYPGKngAQLLVHIVFKVARLLQPSVIWIgnteKTFYKK 642
Cdd:cd19526   25 RLRSGILLYGPPGCGKTLLASAIASECGLNFISVKGPELLNKYIGA--SEQNVRDLFSRAQSAKPCILFF----DEFDSI 98

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 282721066 643 VPK--EERTMDPKRIKKDLMRATKQLSPGDRVMLIGTTERPQL 683
Cdd:cd19526   99 APKrgHDSTGVTDRVVNQLLTQLDGVEGLDGVYVLAATSRPDL 141
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
 566-632 3.26e-03

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 40.91  E-value: 3.26e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 282721066 566 RSILLVGPSGMGKKMLVQAVCTETGANLFDLSPDNLMGKYPGkNGAQLlVHIVFKVARLLQPSVIWI 632
Cdd:PTZ00361 218 KGVILYGPPGTGKTLLAKAVANETSATFLRVVGSELIQKYLG-DGPKL-VRELFRVAEENAPSIVFI 282
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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