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Conserved domains on  [gi|37620210|ref|NP_932342|]
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cytochrome c oxidase assembly protein COX20, mitochondrial isoform 1 [Homo sapiens]

Protein Classification

COX20 family protein( domain architecture ID 38241)

COX20 family protein is a DUF3767 domain-containing protein; similar to Mus musculus mitochondrial cytochrome c oxidase assembly protein COX20, which is essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase

Gene Ontology:  GO:0033617

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cox20 super family cl13972
Cytochrome c oxidase assembly protein COX20; Complex IV (CIV) is a copper-heme oxidase that ...
 14-98 1.55e-12

Cytochrome c oxidase assembly protein COX20; Complex IV (CIV) is a copper-heme oxidase that couples electron transfer from cytochrome c to oxygen with proton extrusion across the inner membrane to contribute to the proton gradient required for ATP generation. This entry includes fungal mitochondrial complex IV assembly factor Cox20 and its homologs (also known as FAM36A in metazoa. Human CIV is formed by three catalytic core subunits (COX1/2/3). COX20 has been found to form a complex with SCO1, SCO2, and newly synthesized COX2. It may act as a chaperone in the early steps of COX2 maturation.


The actual alignment was detected with superfamily member pfam12597:

Pssm-ID: 403707  Cd Length: 101  Bit Score: 58.71  E-value: 1.55e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37620210    14 KSLKLLGFLDVENTPCARHSILYGslgsVVAGFG----HFLFTSRIRRSCDVGVGGFILVTLGCWFHCRYNYAKQRIQER 89
Cdd:pfam12597   9 KSIKLSDFTNFHKIPCARDALLTG----IGAGFVvgglRFLLGKNPPKAANWAVGGFALGSIVGYEQCQYRRRKEFEGMK 84


                  ....*....
gi 37620210    90 IAREEIKKK 98
Cdd:pfam12597  85 RAVEVVAEK 93
 
Name Accession Description Interval E-value
Cox20 pfam12597
Cytochrome c oxidase assembly protein COX20; Complex IV (CIV) is a copper-heme oxidase that ...
 14-98 1.55e-12

Cytochrome c oxidase assembly protein COX20; Complex IV (CIV) is a copper-heme oxidase that couples electron transfer from cytochrome c to oxygen with proton extrusion across the inner membrane to contribute to the proton gradient required for ATP generation. This entry includes fungal mitochondrial complex IV assembly factor Cox20 and its homologs (also known as FAM36A in metazoa. Human CIV is formed by three catalytic core subunits (COX1/2/3). COX20 has been found to form a complex with SCO1, SCO2, and newly synthesized COX2. It may act as a chaperone in the early steps of COX2 maturation.


Pssm-ID: 403707  Cd Length: 101  Bit Score: 58.71  E-value: 1.55e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37620210    14 KSLKLLGFLDVENTPCARHSILYGslgsVVAGFG----HFLFTSRIRRSCDVGVGGFILVTLGCWFHCRYNYAKQRIQER 89
Cdd:pfam12597   9 KSIKLSDFTNFHKIPCARDALLTG----IGAGFVvgglRFLLGKNPPKAANWAVGGFALGSIVGYEQCQYRRRKEFEGMK 84


                  ....*....
gi 37620210    90 IAREEIKKK 98
Cdd:pfam12597  85 RAVEVVAEK 93
 
Name Accession Description Interval E-value
Cox20 pfam12597
Cytochrome c oxidase assembly protein COX20; Complex IV (CIV) is a copper-heme oxidase that ...
 14-98 1.55e-12

Cytochrome c oxidase assembly protein COX20; Complex IV (CIV) is a copper-heme oxidase that couples electron transfer from cytochrome c to oxygen with proton extrusion across the inner membrane to contribute to the proton gradient required for ATP generation. This entry includes fungal mitochondrial complex IV assembly factor Cox20 and its homologs (also known as FAM36A in metazoa. Human CIV is formed by three catalytic core subunits (COX1/2/3). COX20 has been found to form a complex with SCO1, SCO2, and newly synthesized COX2. It may act as a chaperone in the early steps of COX2 maturation.


Pssm-ID: 403707  Cd Length: 101  Bit Score: 58.71  E-value: 1.55e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37620210    14 KSLKLLGFLDVENTPCARHSILYGslgsVVAGFG----HFLFTSRIRRSCDVGVGGFILVTLGCWFHCRYNYAKQRIQER 89
Cdd:pfam12597   9 KSIKLSDFTNFHKIPCARDALLTG----IGAGFVvgglRFLLGKNPPKAANWAVGGFALGSIVGYEQCQYRRRKEFEGMK 84


                  ....*....
gi 37620210    90 IAREEIKKK 98
Cdd:pfam12597  85 RAVEVVAEK 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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