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Conserved domains on  [gi|3024316|sp|O35214|]
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RecName: Full=Visual pigment-like receptor peropsin

Protein Classification

G protein-coupled receptor family protein; olfactory receptor subfamily 2A protein( domain architecture ID 11606771)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters| olfactory receptor (OR) subfamily 2A protein, such as human olfactory receptor 2A2 and related proteins in other mammals and sauropsids; ORs play a central role in olfaction, the sense of smell, and belong to the class A rhodopsin-like family of seven-transmembrane G protein-coupled receptors (7TM GPCRs)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
26-305 2.18e-175

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


:

Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 487.32  E-value: 2.18e-175
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   26 SVIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLN 105
Cdd:cd15073   1 NIVAAYLIVAGIISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLN 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  106 IFFGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTGATCTINWRNNDTS 185
Cdd:cd15073  81 IFFGMASIGLLTVVAVDRYLTICRPDLGRKMTTNTYTVMILLAWTNAFFWAAMPLVGWASYALDPTGATCTINWRKNDSS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  186 FVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAASDCTAHLHRDWADQADVTKMSVIMILMFLLAWSPYSIVCLWACF 265
Cdd:cd15073 161 FVSYTMSVIVVNFIVPLAVMFYCYYNVSRFVKKVLASDCLESVNIDWTDQNDVTKMSVIMIVMFLVAWSPYSIVCLWASF 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 3024316  266 GNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKAM 305
Cdd:cd15073 241 GEPKKIPPWMAIIPPLFAKSSTFYNPCIYVIANKKFRRAI 280
 
Name Accession Description Interval E-value
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
26-305 2.18e-175

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 487.32  E-value: 2.18e-175
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   26 SVIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLN 105
Cdd:cd15073   1 NIVAAYLIVAGIISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLN 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  106 IFFGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTGATCTINWRNNDTS 185
Cdd:cd15073  81 IFFGMASIGLLTVVAVDRYLTICRPDLGRKMTTNTYTVMILLAWTNAFFWAAMPLVGWASYALDPTGATCTINWRKNDSS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  186 FVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAASDCTAHLHRDWADQADVTKMSVIMILMFLLAWSPYSIVCLWACF 265
Cdd:cd15073 161 FVSYTMSVIVVNFIVPLAVMFYCYYNVSRFVKKVLASDCLESVNIDWTDQNDVTKMSVIMIVMFLVAWSPYSIVCLWASF 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 3024316  266 GNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKAM 305
Cdd:cd15073 241 GEPKKIPPWMAIIPPLFAKSSTFYNPCIYVIANKKFRRAI 280
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
43-294 2.53e-41

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 144.75  E-value: 2.53e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316     43 NVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDL-HGSWKFGHAGCQIYAGLNIFFGMVSIGLLTVVAM 121
Cdd:pfam00001   2 NLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLnHGDWPFGSALCKIVGALFVVNGYASILLLTAISI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316    122 DRYLTISCPDVGRRMTTNTY-LSMILGAWINGLFWALMPII-GWASYAPDPTGATCTINWRNNDTSFVSYTMMVIVVNFI 199
Cdd:pfam00001  82 DRYLAIVHPLRYKRRRTPRRaKVLILVIWVLALLLSLPPLLfGWTLTVPEGNVTVCFIDFPEDLSKPVSYTLLISVLGFL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316    200 VPLTVMFYCYYHVSRSLRLYAASDctaHLHRDWADQADVTKMSVIMILMFLLAWSPYSIVCLWACFGNPKKIP---PSMA 276
Cdd:pfam00001 162 LPLLVILVCYTLIIRTLRKSASKQ---KSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSrllDKAL 238
                         250
                  ....*....|....*...
gi 3024316    277 IIAPLFAKSSTFYNPCIY 294
Cdd:pfam00001 239 SVTLWLAYVNSCLNPIIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
37-305 9.58e-10

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 59.02  E-value: 9.58e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316    37 ITSILSNVVVLGIFIKYKeLRTPTNAVIINLAFTDIgVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFGMVSIGLL 116
Cdd:PHA03087  52 FFGLVGNIIVIYVLTKTK-IKTPMDIYLLNLAVSDL-LFVMTLPFQIYYYILFQWSFGEFACKIVSGLYYIGFYNSMNFI 129
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   117 TVVAMDRYLTISCPDVGRRMTTNTYLSMI-LGAWINGLFwALMPIIGWASYAPDPTGATCTINWRNNDTS---FVSYTMM 192
Cdd:PHA03087 130 TVMSVDRYIAIVHPVKSNKINTVKYGYIVsLVIWIISII-ETTPILFVYTTKKDHETLICCMFYNNKTMNwklFINFEIN 208
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   193 VIvvNFIVPLTVMFYCYYHVSRSLRLYAASDctahlhrdwaDQADVTKMSVIMILMFLLAWSPYSIVCLWACFGNPKKIP 272
Cdd:PHA03087 209 II--GMLIPLTILLYCYSKILITLKGINKSK----------KNKKAIKLVLIIVILFVIFWLPFNVSVFVYSLHILHFKS 276
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 3024316   273 PSMAI--------IAPLFAKSSTFYNPCIYVAAHKKFRKAM 305
Cdd:PHA03087 277 GCKAVkyiqyalhVTEIISLSHCCINPLIYAFVSEFFNKHK 317
 
Name Accession Description Interval E-value
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
26-305 2.18e-175

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 487.32  E-value: 2.18e-175
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   26 SVIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLN 105
Cdd:cd15073   1 NIVAAYLIVAGIISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLN 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  106 IFFGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTGATCTINWRNNDTS 185
Cdd:cd15073  81 IFFGMASIGLLTVVAVDRYLTICRPDLGRKMTTNTYTVMILLAWTNAFFWAAMPLVGWASYALDPTGATCTINWRKNDSS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  186 FVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAASDCTAHLHRDWADQADVTKMSVIMILMFLLAWSPYSIVCLWACF 265
Cdd:cd15073 161 FVSYTMSVIVVNFIVPLAVMFYCYYNVSRFVKKVLASDCLESVNIDWTDQNDVTKMSVIMIVMFLVAWSPYSIVCLWASF 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 3024316  266 GNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKAM 305
Cdd:cd15073 241 GEPKKIPPWMAIIPPLFAKSSTFYNPCIYVIANKKFRRAI 280
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
26-305 7.53e-99

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 293.34  E-value: 7.53e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   26 SVIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLN 105
Cdd:cd14969   1 YVLAVYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  106 IFFGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTGATCTINWRNNDTS 185
Cdd:cd14969  81 TFLGLVSISTLAALAFERYLVIVRPLKAFRLSKRRALILIAFIWLYGLFWALPPLFGWSSYVPEGGGTSCSVDWYSKDPN 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  186 FVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLR----LYAASDCTAHLHRDWADQADVTKMSVIMILMFLLAWSPYSIVCL 261
Cdd:cd14969 161 SLSYIVSLFVFCFFLPLAIIIFCYYKIYRTLRkmskRAARRKNSAITKRTKKAEKKVAKMVLVMIVAFLIAWTPYAVVSL 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 3024316  262 WACFGNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKAM 305
Cdd:cd14969 241 YVSFGGESTIPPLLATIPALFAKSSTIYNPIIYVFMNKQFRRAL 284
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
27-303 3.73e-80

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 245.65  E-value: 3.73e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNI 106
Cdd:cd15074   2 IIGIYLTVIGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFCGF 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTGATCTINW--RNNDT 184
Cdd:cd15074  82 LFGCCSINTLTAISIYRYLKICHPPYGPKLSRRHVCIVIVAIWLYALFWAVAPLVGWGSYGPEPFGTSCSIDWtgASASV 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  185 SFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLR--LYAASDCTAHLHRDWADQADVTKMSVIMILMFLLAWSPYSIVCLW 262
Cdd:cd15074 162 GGMSYIISIFIFCYLLPVLIIVFSYVKIIRKVKssRKRVAGFDSRSKRQHKIERKVTKVAVLICAGFLIAWTPYAVVSMW 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 3024316  263 ACFGNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRK 303
Cdd:cd15074 242 SAFGSPDSVPILASILPALFAKSSCMYNPIIYLLFSSKFRQ 282
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
26-304 3.00e-68

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 215.27  E-value: 3.00e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   26 SVIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLN 105
Cdd:cd15083   1 YVLGIFILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  106 IFFGMVSIGLLTVVAMDRYLTISCPDVGR-RMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTGATCTINWRNNDT 184
Cdd:cd15083  81 GLFGIMSINTLAAIAVDRYLVITRPMKASvRISHRRALIVIAVVWLYSLLWVLPPLFGWSRYVLEGLLTSCSFDYLSRDD 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  185 SFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLR-----LYAASDCTAHLHRDWAD---QADV--TKMSVIMILMFLLAWS 254
Cdd:cd15083 161 ANRSYVICLLIFGFVLPLLIIIYCYSFIFRAVRrhekaMKEMAKRFSKSELSSPKarrQAEVktAKIALLLVLLFCLAWT 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 3024316  255 PYSIVCLWACFGNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15083 241 PYAVVALIGQFGYLEVLTPLATAIPAAFAKTSAIYNPVIYAFSHPKFRRA 290
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
27-305 1.55e-62

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 200.63  E-value: 1.55e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVS-SIGYPMSAASDLHGSWKFGHAGCQIYAGLN 105
Cdd:cd15337   2 LIGIYIAIVGILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFSaVNGFPLKTISSFNKKWIWGKVACELYGFAG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  106 IFFGMVSIGLLTVVAMDRYLTISCP-DVGRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTGATCTINWRNNDT 184
Cdd:cd15337  82 GIFGFMSITTLAAISIDRYLVIAKPlEAMKKMTFKRAFIMIIIIWLWSLLWSIPPFFGWGRYVPEGFQTSCTFDYLSRDL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  185 SFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRLY-------AASDCTAHLHRDWAD-QAD--VTKMSVIMILMFLLAWS 254
Cdd:cd15337 162 NNRLFILGLFIFGFLCPLLIIIFCYVNIIRAVRNHekemtqtAKSGMGKDTEKNDARkKAEirIAKVAIILISLFLLSWT 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 3024316  255 PYSIVCLWACFGNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKAM 305
Cdd:cd15337 242 PYAVVALLGQFGPAYWITPYVSELPVMFAKASAIYNPIIYALSHPKFRAAL 292
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
28-305 8.78e-61

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 196.26  E-value: 8.78e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   28 IAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSsIGYPMSAASDLHGSWKFGHAGCQIYAGLNIF 107
Cdd:cd15079   3 LGFIYIFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMM-IKMPIFIYNSFYEGWALGPLGCQIYAFLGSL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  108 FGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILGAWINGLFWALMP-IIGWASYAPDPTGATCTINWRNNDTSF 186
Cdd:cd15079  82 SGIGSIWTNAAIAYDRYNVIVKPLNGNPLTRGKALLLILFIWLYALPWALLPlLFGWGRYVPEGFLTSCSFDYLTRDWNT 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  187 VSYTMMVIVVNFIVPLTVMFYCYYHV-------SRSLRLYAASDCTAHLHRDWADQAD-----VTKMSVIMILMFLLAWS 254
Cdd:cd15079 162 RSFVATIFVFAYVIPLIIIIYCYSFIvkavfahEKALREQAKKMNVVSLRSNADANKQsaeirIAKVALTNVFLWFIAWT 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 3024316  255 PYSIVCLWACFGNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKAM 305
Cdd:cd15079 242 PYAVVALIGAFGNQSLLTPLVSMIPALFAKTAACYNPIVYAISHPKYRLEL 292
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
27-305 1.38e-57

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 188.00  E-value: 1.38e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNI 106
Cdd:cd15336   2 TVGSVILIIGITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGCELYAFCGA 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGMVSIGLLTVVAMDRYLTISCP-DVGRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTGATCTINWRNNDTS 185
Cdd:cd15336  82 LFGITSMITLLAISLDRYLVITKPlASIRWVSKKRAMIIILLVWLYSLAWSLPPLFGWSAYVPEGLLTSCTWDYMTFTPS 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  186 FVSYTMMVIVVNFIVPLTVMFYCYY-------HVSRSLRLYAASDC--TAHLHRDWADQADVTKMSVIMILMFLLAWSPY 256
Cdd:cd15336 162 VRAYTMLLFCFVFFIPLGIIIYCYLfiflairSTGREVQKLGSQDRkeKAKQYQRMKNEWKMAKIAFVVILLFVLSWSPY 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 3024316  257 SIVCLWACFGNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKAM 305
Cdd:cd15336 242 ACVALIAWAGYAHLLTPYMKSVPAVIAKASAIYNPIIYAITHPKYREAI 290
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
27-303 1.72e-56

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 184.56  E-value: 1.72e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNI 106
Cdd:cd15086   2 VVAVFLGFILTFGFLNNLLVLVLFCKYKVLRSPINLLLLNISLSDLLVCVLGTPFSFAASTQGRWLIGEHGCRWYGFANS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTGATCTINWRNNDTSF 186
Cdd:cd15086  82 LFGIVSLISLAVLSYERYCTLLRPTEADVSDYRKAWLGVGGSWLYSLLWTLPPLLGWSSYGPEGPGTTCSVQWTSRSANS 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  187 VSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAASDCTAHLHRDWadqaDVTKMSVIMILMFLLAWSPYSIVCLWACFG 266
Cdd:cd15086 162 ISYIICLFIFCLLLPFLVMVYCYGRLLYAIKQVGKINKSTARKREQ----HVLLMVVTMVICYLLCWLPYGVMALLATFG 237
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 3024316  267 NPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRK 303
Cdd:cd15086 238 KPGLVTPVASIVPSILAKSSTVVNPIIYVFMNKQFYR 274
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
28-294 9.22e-49

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 164.77  E-value: 9.22e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   28 IAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIF 107
Cdd:cd00637   1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  108 FGMVSIGLLTVVAMDRYLTISCP-DVGRRMTTNTYLSMILGAWINGLFWALMPIIGWASYapDPTGATCTINWRNNDTSF 186
Cdd:cd00637  81 SLLASILTLTAISVDRYLAIVHPlRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVY--DYGGYCCCCLCWPDLTLS 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  187 VSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAA--SDCTAHLHRDWADQAD--VTKMSVIMILMFLLAWSPYSIVCLW 262
Cdd:cd00637 159 KAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRriRSSSSNSSRRRRRRRErkVTKTLLIVVVVFLLCWLPYFILLLL 238
                       250       260       270
                ....*....|....*....|....*....|...
gi 3024316  263 ACF-GNPKKIPPSMAIIAPLFAKSSTFYNPCIY 294
Cdd:cd00637 239 DVFgPDPSPLPRILYFLALLLAYLNSAINPIIY 271
7tmA_Retinal_GPR cd15072
retinal G protein coupled receptor, member of the class A family of seven-transmembrane G ...
32-305 2.07e-48

retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the retinal G-protein coupled receptor (RGR) found exclusively in retinal pigment epithelium (RPE) and Muller cells. RGR is a member of the class A rhodopsin-like receptor family. As with other opsins, RGR binds all-trans retinal and contains a conserved lysine reside on the seventh helix. RGR functions as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Two mutations in RGR gene are found in patients with retinitis pigmentosa, indicating that RGR is essential to the visual process.


Pssm-ID: 320200 [Multi-domain]  Cd Length: 260  Bit Score: 163.30  E-value: 2.07e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   32 LIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSsIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFGMV 111
Cdd:cd15072   7 LLVEALVGFSLNGLTILSFCKTRELRTPSNLLVLSLAVADMGIS-LNALVAASSSLLRRWPYGSEGCQAHGFQGFFTALA 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  112 SIGLLTVVAMDRYLTISCPdvgRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTGATCTINWRNNDTSFVSYTM 191
Cdd:cd15072  86 SICSSAAIAWDRYHHYCTR---SKLQWSTAISLVLFVWLFSAFWAAMPLLGWGEYDYEPLGTCCTLDYSKGDRNYVSYLF 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  192 MVIVVNFIVPLTVMFYCYYHVSRSLRLyaasdcTAHLhrdwadqadvTKMSVIMILMFLLAWSPYSIVCLWACFGNPKKI 271
Cdd:cd15072 163 TMAFFNFILPLFILLTSYSSIEQKLKK------EGHL----------RFNTGLPLLTLLICWGPYAILALYAAITDVTSI 226
                       250       260       270
                ....*....|....*....|....*....|....
gi 3024316  272 PPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKAM 305
Cdd:cd15072 227 SPKLRMVPALLAKTSPTINAILYALGNENYRGGI 260
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
26-305 2.85e-46

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 158.81  E-value: 2.85e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   26 SVIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLN 105
Cdd:cd15082  14 TVLAALMFVVTSLSLAENFAVMLVTFRFKQLRQPLNYIIVNLSVADFLVSLTGGTISFLTNARGYFFLGVWACVLEGFAV 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  106 IFFGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTGATCTINWRNNDTS 185
Cdd:cd15082  94 TFFGIVALWSLAVLAFERFFVICRPLGNIRLQGKHAALGLLFVWTFSFIWTIPPVLGWSSYTVSKIGTTCEPNWYSGNMH 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  186 FVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRlyAASDCTAHLHRDWADQADVTKMSVIMILMFLLAWSPYSIVCLWACF 265
Cdd:cd15082 174 DHTYIITFFTTCFILPLGVIFVSYGKLLQKLR--KVSNTQGRLGNARKPERQVTRMVVVMIVAFMVCWTPYAAFSILVTA 251
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 3024316  266 GNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKAM 305
Cdd:cd15082 252 HPTIHLDPRLAAIPAFFSKTAAVYNPIIYVFMNKQFRKCL 291
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
36-305 1.98e-45

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 156.14  E-value: 1.98e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   36 GITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFGMVSIGL 115
Cdd:cd15078  11 GFLGVCNNLLVLILYYKFKRLRTPTNLLLVNISLSDLLVSLLGVTFTFMSCVRGRWVFDVAGCVWDGFSNSLFGIVSIMT 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  116 LTVVAMDRYLTIScpdVGRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTGATCTINWRNNDTSFVSYTMMVIV 195
Cdd:cd15078  91 LTVLAYERYIRVV---HAKVVNFSWSWRAITYIWLYSLAWTGAPLLGWNRYTLEVHGLGCSFDWKSKDPNDTSFVLLFFL 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  196 VNFIVPLTVMFYCYYHVSRSLR-LYAASDC-TAHLHRDWADQADVTKMSVIMILMFLLAWSPYSIVCLWACFGNPKKIPP 273
Cdd:cd15078 168 GCLVVPLGIMAYCYGHILYEIRmLRSVEDLqTFQVIKILKYEKKVAKMCLLMISTFLICWMPYAVVSLLVTSGYSKLVTP 247
                       250       260       270
                ....*....|....*....|....*....|..
gi 3024316  274 SMAIIAPLFAKSSTFYNPCIYVAAHKKFRKAM 305
Cdd:cd15078 248 TIAIIPSLFAKSSTAYNPVIYIFMIRKFRQCL 279
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
26-302 2.91e-44

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 153.08  E-value: 2.91e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   26 SVIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCqIYAGLN 105
Cdd:cd15085   1 SILSFLMFLNATFSIFNNVLVIAVTLKNPQLRNPINIFILNLSFSDLMMALCGTTIVTVTNYEGYFYLGDAFC-IFQGFA 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  106 I-FFGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTGATCTINWRNNDT 184
Cdd:cd15085  80 VnYFGIVSLWSLTLLAYERYNVVCKPMGGLKLSTKRGYQGLLFIWLFCLFWAVAPLFGWSSYGPEGVQTSCSIGWEERSW 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  185 SFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAASDCTAHLHRDWADQADVTKMSVIMILMFLLAWSPYSIVCLWAC 264
Cdd:cd15085 160 SNYSYLILYFLMCFVIPVAIIGFSYGNVLRSLHKLNKKIEQQGGKNCPEEEERAVIMVLAMVIAFLICWLPYTVFALIVV 239
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 3024316  265 FGNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFR 302
Cdd:cd15085 240 VNPELSISPLAATMPTYFAKTSPVYNPIIYIFLNKQFR 277
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
27-305 3.36e-44

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 152.33  E-value: 3.36e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNI 106
Cdd:cd14967   1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGMVSIGLLTVVAMDRYLTISCP-DVGRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTGATCTINWRNNDts 185
Cdd:cd14967  81 LCCTASILNLCAISLDRYLAITRPlRYRQLMTKKRALIMIAAVWVYSLLISLPPLVGWRDETQPSVVDCECEFTPNKI-- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  186 fvsYTMMVIVVNFIVPLTVMFYCYYHVSRSLRlyaasdctaHLHRdwadqadVTKMSVIMILMFLLAWSPYSIVCLWACF 265
Cdd:cd14967 159 ---YVLVSSVISFFIPLLIMIVLYARIFRVAR---------RELK-------AAKTLAIIVGAFLLCWLPFFIIYLVSAF 219
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 3024316  266 GNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKAM 305
Cdd:cd14967 220 CPPDCVPPILYAVFFWLGYLNSALNPIIYALFNRDFRRAF 259
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
21-311 1.42e-41

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 146.55  E-value: 1.42e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   21 SRTEHSVIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQI 100
Cdd:cd15084   6 PRSTYLTVAVLMGMVVALASFVNGLVIVVSIKYKKLRSPLNYILVNLAVADLLVTLFGSSVSFSNNIVGFFVFGKTMCEF 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  101 YAGLNIFFGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTGATCTINWR 180
Cdd:cd15084  86 EGFMVSLTGIVGLWSLAILAFERYLVICKPMGDFRFQQRHAVSGCAFTWGWSLLWTSPPLFGWSSYVPEGLRTSCGPNWY 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  181 NNDTSFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAA----SDCTAHLHRdwadqaDVTKMSVIMILMFLLAWSPY 256
Cdd:cd15084 166 TGGTNNNSYILALFVTCFALPLSTIIFSYSNLLLTLRAVAAqqkeSETTQRAEK------EVTRMVIAMVMAFLICWLPY 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 3024316  257 SIVCLWACFGNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKAMLAMFKC 311
Cdd:cd15084 240 ATFAMVVATNKDVVIQPTLASLPSYFSKTATVYNPIIYVFMNKQFRSCLLELLCC 294
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
43-294 2.53e-41

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 144.75  E-value: 2.53e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316     43 NVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDL-HGSWKFGHAGCQIYAGLNIFFGMVSIGLLTVVAM 121
Cdd:pfam00001   2 NLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLnHGDWPFGSALCKIVGALFVVNGYASILLLTAISI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316    122 DRYLTISCPDVGRRMTTNTY-LSMILGAWINGLFWALMPII-GWASYAPDPTGATCTINWRNNDTSFVSYTMMVIVVNFI 199
Cdd:pfam00001  82 DRYLAIVHPLRYKRRRTPRRaKVLILVIWVLALLLSLPPLLfGWTLTVPEGNVTVCFIDFPEDLSKPVSYTLLISVLGFL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316    200 VPLTVMFYCYYHVSRSLRLYAASDctaHLHRDWADQADVTKMSVIMILMFLLAWSPYSIVCLWACFGNPKKIP---PSMA 276
Cdd:pfam00001 162 LPLLVILVCYTLIIRTLRKSASKQ---KSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSrllDKAL 238
                         250
                  ....*....|....*...
gi 3024316    277 IIAPLFAKSSTFYNPCIY 294
Cdd:pfam00001 239 SVTLWLAYVNSCLNPIIY 256
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
27-302 1.51e-39

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 140.68  E-value: 1.51e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNI 106
Cdd:cd15075   2 ILSIIMAVFSIASVVLNATVIIVTLRHKQLRQPLNYALVNLAVADLGTTVFGGLLSVVTNAVGYFNLGRVGCVLEGFAVA 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTGATCTINWRNNDTSF 186
Cdd:cd15075  82 FFGIAALCTVAVIAVDRLFVVCKPLGTLTFQTRHALAGIASSWLWSLIWNTPPLFGWGSYQLEGVMTSCAPDWYSRDPVN 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  187 VSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAASDCTAHlHRDWADQADVTKMSVIMILMFLLAWSPYSIVCLWACFG 266
Cdd:cd15075 162 VSYILCYFSFCFAIPFAIILVSYGYLLWTLRQVAKLGVAEG-GSTAKAEVQVARMVVVMVMAFLLCWLPYAAFALTVVSK 240
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 3024316  267 NPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFR 302
Cdd:cd15075 241 PDVYINPLIATVPMYLAKSSTVYNPIIYIFMNKQFR 276
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
26-305 3.90e-39

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 139.58  E-value: 3.90e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   26 SVIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLN 105
Cdd:cd15080   1 SALAAYMFLLILLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVFGPTGCNLEGFFA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  106 IFFGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTGATCTINWRN---- 181
Cdd:cd15080  81 TLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTlkpe 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  182 -NDTSFVSYtmmVIVVNFIVPLTVMFYCYYHVSRSLRLYAA----SDCTAHLHRdwadqaDVTKMSVIMILMFLLAWSPY 256
Cdd:cd15080 161 vNNESFVIY---MFVVHFTIPLIVIFFCYGRLVCTVKEAAAqqqeSATTQKAEK------EVTRMVIIMVIAFLICWVPY 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 3024316  257 SIVCLWACFGNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKAM 305
Cdd:cd15080 232 ASVAFYIFTHQGSDFGPIFMTIPAFFAKSSAVYNPVIYILMNKQFRNCM 280
7tmA_SWS2_opsin cd15077
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...
27-305 1.39e-35

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320205 [Multi-domain]  Cd Length: 280  Bit Score: 130.33  E-value: 1.39e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNI 106
Cdd:cd15077   2 GMSAFMLFLVIAGFPINVLTIICTIKYKKLRSHLNYILVNLAVANLIVVCFGSTTAFYSFSQMYFVLGPLACKIEGFTAT 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTGATCTINW--RNNDT 184
Cdd:cd15077  82 LGGMVSLWSLAVVAFERFLVICKPLGNFTFRGTHAIIGCIATWVFGLAASLPPLFGWSRYIPEGLQCSCGPDWytTNNKW 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  185 SFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAA----SDCTAHLHRDwadqadVTKMSVIMILMFLLAWSPYSIVC 260
Cdd:cd15077 162 NNESYVMFLFCFCFGVPLSIIVFSYGRLLLTLRAVAKqqeqSASTQKAERE------VTKMVVVMVLGFLVCWLPYASFA 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 3024316  261 LWACFGNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKAM 305
Cdd:cd15077 236 LWVVTNRGEPFDLRLASIPSVFSKASTVYNPVIYVFMNKQFRSCM 280
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
28-305 4.94e-33

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 123.87  E-value: 4.94e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   28 IAAYLIVAgITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYA---GL 104
Cdd:cd15203   4 ILLYGLII-VLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPFTLIYTLTKNWPFGSILCKLVPslqGV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  105 NIFfgmVSIGLLTVVAMDRYLTISCPdVGRRMTTNTYLSMILGAWINGLFWAL-----MPIIGWASYAPDPTGATCTINW 179
Cdd:cd15203  83 SIF---VSTLTLTAIAIDRYQLIVYP-TRPRMSKRHALLIIALIWILSLLLSLplaifQELSDVPIEILPYCGYFCTESW 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  180 RNNDTSFVsYTMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAASDCTAHLHRDWADQADV------TKMSVIMILMFLLAW 253
Cdd:cd15203 159 PSSSSRLI-YTISVLVLQFVIPLLIISFCYFRISLKLRKRVKKKRGKRTLSSRRRRSELrrkrrtNRLLIAMVVVFAVCW 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 3024316  254 SPYSIVCLWACFGNPKKIPPS----MAIIAPLFAKSSTFYNPCIYVAAHKKFRKAM 305
Cdd:cd15203 238 LPLNLFNLLRDFEPLPQIDGRhfylIFLICHLIAMSSACVNPLLYGWLNDNFRKEF 293
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
22-302 5.63e-33

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 123.86  E-value: 5.63e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   22 RTEHSVIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIY 101
Cdd:cd15081   9 RWVYNLTSVWMIFVVFASVFTNGLVLVATLKFKKLRHPLNWILVNLAIADLGETVIASTISVVNQIFGYFILGHPMCVLE 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  102 AGLNIFFGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTGATC--TINW 179
Cdd:cd15081  89 GFTVSVCGITGLWSLTIISWERWVVVCKPFGNIKFDGKLAIVGIIFSWVWSAVWCAPPIFGWSRYWPHGLKTSCgpDVFS 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  180 RNNDTSFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAA----SDCTAHLHRDwadqadVTKMSVIMILMFLLAWSP 255
Cdd:cd15081 169 GSSDPGVQSYMIVLMITCCIIPLAIIILCYLQVWLAIRAVAQqqkeSESTQKAEKE------VSRMVVVMIFAYCFCWGP 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 3024316  256 YSIVCLWACFGNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFR 302
Cdd:cd15081 243 YTFFACFAAANPGYAFHPLAAALPAYFAKSATIYNPIIYVFMNRQFR 289
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
27-304 2.33e-28

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 110.50  E-value: 2.33e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNI 106
Cdd:cd15064   2 LISVLLSLIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGRWILGQVLCDIWISLDV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGMVSIGLLTVVAMDRYLTISCP-DVGRRMTTNTYLSMILGAWINGLFWALMPIIGW-ASYAPDPTgaTCTINwrnndt 184
Cdd:cd15064  82 TCCTASILHLCVIALDRYWAITDAvEYAHKRTPKRAAVMIALVWTLSICISLPPLFGWrTPDSEDPS--ECLIS------ 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  185 SFVSYTMMVIVVNFIVPLTVMFYCYYhvsrslRLYAASdctahlhrdwADQADVTKMSVIMILMFLLAWSPYSIVCLWAC 264
Cdd:cd15064 154 QDIGYTIFSTFGAFYIPLLLMLILYW------KIYRAA----------ARERKAAKTLGIILGAFIVCWLPFFLVALIVP 217
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 3024316  265 FGNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15064 218 LCSHCWIPLALKSFFLWLGYFNSLINPLIYTFFNKDFRKA 257
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
28-305 1.11e-27

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 109.61  E-value: 1.11e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   28 IAAYLIVAgITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIF 107
Cdd:cd14993   4 IVLYVVVF-LLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYRPWVFGEVLCKAVPYLQGV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  108 FGMVSIGLLTVVAMDRYLTISCPDVGRR-MTTNTYLSMILGAWINGLFwALMPII-------GWASYAPDPTGATCTINW 179
Cdd:cd14993  83 SVSASVLTLVAISIDRYLAICYPLKARRvSTKRRARIIIVAIWVIAII-IMLPLLvvyeleeIISSEPGTITIYICTEDW 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  180 RNNDTSFVsYTMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAASDCTAHLHRDWADQAD-----VTKMSVIMILMFLLAWS 254
Cdd:cd14993 162 PSPELRKA-YNVALFVVLYVLPLLIISVAYSLIGRRLWRRKPPGDRGSANSTSSRRILrskkkVARMLIVVVVLFALSWL 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 3024316  255 PYSIVCLWACFGNPKKIPPSMAI-----IAPLFAKSSTFYNPCIYVAAHKKFRKAM 305
Cdd:cd14993 241 PYYVLSILLDFGPLSSEESDENFllilpFAQLLGYSNSAINPIIYCFMSKKFRRGF 296
7tmA_SWS1_opsin cd15076
short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G ...
43-302 2.87e-27

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320204 [Multi-domain]  Cd Length: 280  Bit Score: 107.98  E-value: 2.87e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   43 NVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFGMVSIGLLTVVAMD 122
Cdd:cd15076  18 NAIVLFVTIKYKKLRQPLNYILVNISLAGFIFCIFSVFPVFVASAQGYFFFGRTVCALEAFVGSLAGLVTGWSLAFLAFE 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  123 RYLTISCPDVGRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTGATCTINWRNNDTSFVS--YTMMVIVVNFIV 200
Cdd:cd15076  98 RYIVICKPFGNFRFGSKHALGAVVATWIIGIGVSLPPFFGWSRYIPEGLQCSCGPDWYTVGTKYRSeyYTWFLFIFCFIV 177
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  201 PLTVMFYCYYHVSRSLRLYAA----SDCTAHLHRdwadqaDVTKMSVIMILMFLLAWSPYSIVCLWACFGNPKKIPPSMA 276
Cdd:cd15076 178 PLSIIIFSYSQLLGALRAVAAqqqeSASTQKAER------EVSRMVVVMVGSFCLCYVPYAALAMYMVNNRDHGLDLRLV 251
                       250       260
                ....*....|....*....|....*.
gi 3024316  277 IIAPLFAKSSTFYNPCIYVAAHKKFR 302
Cdd:cd15076 252 TIPAFFSKSSCVYNPIIYCFMNKQFR 277
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
29-304 2.59e-26

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 105.04  E-value: 2.59e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   29 AAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLniFF 108
Cdd:cd15210   4 AVWGIVFMVVGVPGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFNLPLAASTFLHQAWIHGETLCRVFPLL--RY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  109 GMVSIGLLTVV--AMDRYLTISCPDVGRRMTTNTYLS-MILGAWINGLFWALMPIIG-WASYAPDPTGATCTINWRNNDT 184
Cdd:cd15210  82 GLVAVSLLTLVliTLNRYILIAHPSLYPRIYTRRGLAlMIAGTWIFSFGSFLPLWLGiWGRFGLDPKVCSCSILRDKKGR 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  185 sfvSYTMMVIVVNFIVPLTVMFYCYYhvsrslrlyaasdctahlhRDWADQadVTKMSVIMILMFLLAWSPYSIVCLWac 264
Cdd:cd15210 162 ---SPKTFLFVFGFVLPCLVIIICYA-------------------RREDRR--LTRMMLVIFLCFLVCYLPITLVNVF-- 215
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 3024316  265 fgNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15210 216 --DDEVAPPVLHIIAYVLIWLSSCINPIIYVAMNRQYRQA 253
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
26-303 5.12e-26

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 104.82  E-value: 5.12e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   26 SVIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLN 105
Cdd:cd14992   1 IILGVALVVIILVSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNFTYVVSLSWEYGHFLCKIVNYLR 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  106 IFFGMVSIGLLTVVAMDRYLTISCP-DVGRRMTTNTYLSMILGAWINGLFWALmPIIGWASYAPDPT------GATCTIN 178
Cdd:cd14992  81 TVSVYASSLTLTAIAFDRYFAIIHPlKPRHRQSYTTTVIIIITIWVVSLLLAI-PQLYYATTEVLFSvknqekIFCCQIP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  179 WRNNDTSFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSL--RLYAASDCTAHLHRDWADQADVTKMSVIMILMFLLAWSPY 256
Cdd:cd14992 160 PVDNKTYEKVYFLLIFVVIFVLPLIVMTLAYARISRELwfRKVPGFSIKEVERKRLKCKRRVIKMLVCVVVLFVICWLPF 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 3024316  257 SIVCLWACFgNPKKIPPSMAIIAPLF----AKSSTFYNPCIYVAAHKKFRK 303
Cdd:cd14992 240 HLFFLLRDF-FPLIMKEKHTLQVYYFlhwiAMSNSMYNPIIYVTLNNNFRK 289
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
26-302 6.32e-26

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 104.68  E-value: 6.32e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   26 SVIAAYLIVAgITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLN 105
Cdd:cd15390   2 LWSIVFVVMV-LVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLYNDWPFGLFYCKFSNFVA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  106 IFFGMVSIGLLTVVAMDRYLTISCPdVGRRMTTNTYLSMILGAWINGLFWALmPIIGWA-----SYAPDPTGATCTINWR 180
Cdd:cd15390  81 ITTVAASVFTLMAISIDRYIAIVHP-LRPRLSRRTTKIAIAVIWLASFLLAL-PQLLYSttetyYYYTGSERTVCFIAWP 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  181 NNDTSFVS--YTMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAA-SDCTAHLHRDWADQADVTKMSVIMILMFLLAWSPYS 257
Cdd:cd15390 159 DGPNSLQDfvYNIVLFVVTYFLPLIIMAVAYTRVGVELWGSKTiGENTPRQLESVRAKRKVVKMMIVVVVIFAICWLPYH 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 3024316  258 IVCLWACFGNPKKIPPSMAIIAPLF---AKSSTFYNPCIYVAAHKKFR 302
Cdd:cd15390 239 LYFILTYLYPDINSWKYIQQIYLAIywlAMSNSMYNPIIYCWMNKRFR 286
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
28-302 2.80e-25

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 103.00  E-value: 2.80e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   28 IAAYLIVagITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIF 107
Cdd:cd16004   5 IAYSLIV--LVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLSMAAFNTAFNFVYASHNDWYFGLEFCRFQNFFPIT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  108 FGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLsMILGAWINGLFWALmPIIGWASYAPDPTGATCTINWRNNDTS-- 185
Cdd:cd16004  83 AMFVSIYSMTAIAADRYMAIIHPFKPRLSAGSTKV-VIAGIWLVALALAF-PQCFYSTVTMDQGRTKCIVAWPGDSGGkh 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  186 FVSYTMMVIVVNFIVPLTVMFYCYYHVSRSL--RLYAASDCTAHLHRDWADQADVTKMSVIMILMFLLAWSPYSIVCLWA 263
Cdd:cd16004 161 QLTYHLAVIVLIYLLPLAVMFVTYSIIGITLwrSAVPGHQAHGAYHRQLQAKKKFVKTMVVVVVTFAICWLPYHLYFILG 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 3024316  264 CFGNP---KKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFR 302
Cdd:cd16004 241 SFNEDiycQKYIQQVYLAIFWLAMSSTMYNPIIYCCLNQRFR 282
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
30-302 1.54e-24

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 100.77  E-value: 1.54e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   30 AYLIVAGItSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFG 109
Cdd:cd16003   6 AYGFVVAV-AVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLINFIYALHSEWYFGEAYCRFHNFFPITSV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  110 MVSIGLLTVVAMDRYLTISCPdVGRRMTTNTYLSMILGAWINGLFWALmPIIGWASYAPDPTGATCTINWRNNDTSFVSY 189
Cdd:cd16003  85 FASIYSMTAIAVDRYMAIIDP-LKPRLSATATKVVIGSIWILAFLLAF-PQCLYSKTKVMPGRTLCFVAWPGGPDQHFTY 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  190 TMMVIVVNFIVPLTVMFYCYYHVSRSL-RLYAASDCTAHLHRDWADQADVTKMSVIMILMFLLAWSPYSIVCLWACFG-- 266
Cdd:cd16003 163 HIIVIVLVYCLPLLVMGITYTIVGITLwGGEIPGDTSDKYHEQLRAKRKVVKMMIIVVLTFAICWLPYHIYFIVTGLYqq 242
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 3024316  267 -NPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFR 302
Cdd:cd16003 243 lNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFR 279
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
27-304 2.15e-24

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 99.74  E-value: 2.15e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNI 106
Cdd:cd15061   1 ILISFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLLGYWPLGSHLCDFWISLDV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGMVSIGLLTVVAMDRYLTISCPDV-GRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDpTGATCTINWrnnDTS 185
Cdd:cd15061  81 LLCTASILNLCCISLDRYFAITYPLKyRTKRSRRLAITMILAVWVISLLITSPPLVGPSWHGRR-GLGSCYYTY---DKG 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  186 FVSYTMMVIvvnFIVPLTVMFYCYYHVSRSLrlyaasdctahlhrdwADQADVTKMSVIMILMFLLAWSPYSIVCLWACF 265
Cdd:cd15061 157 YRIYSSMGS---FFLPLLLMLFVYLRIFRVI----------------AKERKTAKTLAIVVGCFIVCWLPFFIMYLIEPF 217
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 3024316  266 gNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15061 218 -CDCQFSEALSTAFTWLGYFNSVINPFIYAFYNKDFRRA 255
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
28-304 9.05e-24

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 98.21  E-value: 9.05e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   28 IAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIF 107
Cdd:cd15213   3 LAILMILMIFVGFLGNSIVCLIVYQKPAMRSAINLLLANLAFSDIMLSLVCMPFAAVTIITGRWIFGDIFCRISAMLYWF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  108 FGMVSIGLLTVVAMDRYLTIscpdVGRRMTTNTYLS--MILGAWINGLFWALMPIIGWASYAPDPTGATCTINWrNNDTS 185
Cdd:cd15213  83 FVLEGVAILLIISVDRYLII----VQRQDKLNPHRAkiLIAVSWVLSFCVSFPPLVGWGKYEFPPRAPQCVLGY-TESPA 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  186 FVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAASDCTAHLhrdwadqadvtkmsvIMILMFLLAWSPYSIVCLWACF 265
Cdd:cd15213 158 DRIYVVLLLVAVFFIPFLIMLYSYFCILNTVRSFKTRAFTTIL---------------ILFIGFSVCWLPYTVYSLLSVF 222
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 3024316  266 GNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15213 223 SRYSSSFYVISTCLLWLSYLKSAFNPVIYCWRIKKFREA 261
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
27-304 3.00e-22

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 94.73  E-value: 3.00e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNI 106
Cdd:cd15065   1 LIGIFLSLIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLLGYWLFGETFCNIWISFDV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGMVSIGLLTVVAMDRYLTISCPDV-GRRMTTNTYLSMILGAWINGLFWALMPI-IGWASYAPDPTGATCTINWRNNDT 184
Cdd:cd15065  81 MCSTASILNLCAISLDRYIHIKKPLKyERWMTTRRALVVIASVWILSALISFLPIhLGWHRLSQDEIKGLNHASNPKPSC 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  185 SFVSYTMMVIV---VNFIVPLTVM------FYCY--YHV-------------SRSLRLYAASDCTAHLHRDWadQADVTk 240
Cdd:cd15065 161 ALDLNPTYAVVsslISFYIPCLVMlliysrLYLYarKHVvniksqklpsesgSKFQVPSLSSKHNNQGVSDH--KAAVT- 237
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 3024316  241 MSVIMiLMFLLAWSPYSIVCLWACFgNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15065 238 LGIIM-GVFLICWLPFFIINIIAAF-CKTCIPPKCFKILTWLGYFNSCLNPIIYSIFNSEFRRA 299
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
31-304 9.45e-22

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 93.26  E-value: 9.45e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   31 YLIVagITSILSNVVVLGIFIKYKELRTP-TNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGhAGCQIYAGLNIFFG 109
Cdd:cd15057   8 YLLV--LLTLLGNALVIAAVLRFRHLRSKvTNYFIVSLAVSDLLVAILVMPWAAVNEVAGYWPFG-SFCDVWVSFDIMCS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  110 MVSIGLLTVVAMDRYLTISCP-DVGRRMTTNTYLSMILGAWINGLFWALMPI-IGWASYAPDPTGATCTINWRNNDTSF- 186
Cdd:cd15057  85 TASILNLCVISVDRYWAISSPfRYERRMTRRRAFIMIAVAWTLSALISFIPVqLGWHRADDTSEALALYADPCQCDSSLn 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  187 VSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRLY---------AASDCTA---HLHRDWADQADVTKMSVIMILMFLLAWS 254
Cdd:cd15057 165 RTYAISSSLISFYIPVAIMIVTYTRIYRIARRQirriaalerAAQESTNpdsSLRSSLRRETKALKTLSIIMGVFVCCWL 244
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 3024316  255 PYSIVCLWACF-----GNPKKIPPSMAIIAPLFAKSSTFYNPCIYvAAHKKFRKA 304
Cdd:cd15057 245 PFFILNCVLPFcdlrtAQFPCVPDTTFIVFVWLGWANSSLNPIIY-AFNADFRKA 298
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
27-303 9.74e-22

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 93.13  E-value: 9.74e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSiGYPMSAASDLHGSWKFGHAGCQIYAGLNI 106
Cdd:cd14970   2 VIPAVYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLL-GLPFLATSYLLGYWPFGEVMCKIVLSVDA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGMVSIGLLTVVAMDRYLTISCPDVGRRMTTntyLSMilGAWINGLFWAL-----MPIIGWASYAPDPTGA-TCTINWR 180
Cdd:cd14970  81 YNMFTSIFCLTVMSVDRYLAVVHPVKSLRFRT---PRK--AKLVSLCVWALslvlgLPVIIFARTLQEEGGTiSCNLQWP 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  181 N-NDTSFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAASDCTAHLHRDWADQAdVTKMSVIMILMFLLAWSPYSIV 259
Cdd:cd14970 156 DpPDYWGRVFTIYTFVLGFAVPLLVITVCYSLIIRRLRSSRNLSTSGAREKRRARRK-VTRLVLVVVAVFVVCWLPFHVF 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 3024316  260 CLWACFGNPKKIPPSMAI----IAPLFAKSSTfyNPCIYVAAHKKFRK 303
Cdd:cd14970 235 QIVRLLIDPPETLTVVGVflfcIALSYANSCL--NPILYAFLDENFRK 280
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
26-304 1.70e-21

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 92.03  E-value: 1.70e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   26 SVIAAYLIVAgitSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLN 105
Cdd:cd15331   4 SIILGLLILA---TIIGNVFVIAAILLERSLQGVSNYLILSLAVADLMVAVLVMPLSAVYEVSQHWFLGPEVCDMWISMD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  106 IFFGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILGAWINGLFWALMPIIGWA----SYAPDPTGaTCTINWRn 181
Cdd:cd15331  81 VLCCTASILHLVAIALDRYWAVTNIDYIRRRTAKRILIMIAVVWFVSLIISIAPLFGWKdeddLDRVLKTG-VCLISQD- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  182 ndtsfVSYTMMVIVVNFIVPLTVMFYCYYHVSRslrlyaasdcTAHLHRDWAdqadvtKMSVIMILMFLLAWSPYSIVCL 261
Cdd:cd15331 159 -----YGYTIFSTVGAFYVPLLLMIIIYWKIYQ----------AAKRERKAA------RTLAIITGAFVVCWLPFFLVAL 217
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 3024316  262 WACFGNPKKIPPS-MAIIAPLFAKSSTFyNPCIYVAAHKKFRKA 304
Cdd:cd15331 218 VMPFCGAWQISRFlESFFLWLGYFNSLL-NPIIYTIFSPDFRGA 260
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
27-302 2.26e-21

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 92.18  E-value: 2.26e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAgITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNI 106
Cdd:cd15202   3 LIVAYSFII-VFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGMVSIGLLTVVAMDRYLTISCPdVGRRMTTNTYLSMILGAWINGLFWALMpiIGWAS------YAPDPTGATCTINW- 179
Cdd:cd15202  82 CSVHVSAYTLTAIAVDRYQAIMHP-LKPRISKTKAKFIIAVIWTLALAFALP--HAICSkletfkYSEDIVRSLCLEDWp 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  180 RNNDTSFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRL--YAASDCTAHLHRDWADQADVTKMSVIMILMFLLAWSPYS 257
Cdd:cd15202 159 ERADLFWKYYDLALFILQYFLPLLVISFAYARVGIKLWAsnMPGDATTERYFALRRKKKKVIKMLMVVVVLFALCWLPFN 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 3024316  258 IVCLWACFGNPKKIPPSMAIIAPL--FAKSSTFYNPCIYVAAHKKFR 302
Cdd:cd15202 239 IYVLLLSSKPDYLIKTINAVYFAFhwLAMSSTCYNPFIYCWLNERFR 285
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
29-309 2.66e-21

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 91.75  E-value: 2.66e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   29 AAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHG-SWKFGHAGCQIYAGLNIF 107
Cdd:cd15212   4 ALVLLAIFLLSSLGNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPFAFLTLFSRpGWLFGDRLCLANGFFNAC 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  108 FGMVSIGLLTVVAMDRYLTISCPDVGRrMTTNTYLSMILGAWINGLFWAL-MPIIGWASYAPDPTGATCTINWRNNDTSF 186
Cdd:cd15212  84 FGIVSTLTMTLISFDRYYAIVRQPQGK-IGRRRALQLLAAAWLTALGFSLpWYLLASAPEYYEKLGFYHCLYVLHSGPSR 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  187 V--SYTMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAAS----DCTAHLHRDWADQADVTKMsVIMILMFLLAWSPYSIVC 260
Cdd:cd15212 163 LgaAYSSVLIVLCYLLPFALMCFCHYNICKTVRLSESRvrpvTTYAHLLRFYSEMRTATTV-LIMIVFIICCWGPYCLLG 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 3024316  261 LWACFGNpKKIPPSMAIIAPLFAKSSTFYNPCIYVaahkkFRKAMLAMF 309
Cdd:cd15212 242 LVAAAGG-YQFPPLMDTVAIWMAWANGAINPLIYA-----IRNPNISML 284
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
27-304 3.67e-21

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 91.78  E-value: 3.67e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNI 106
Cdd:cd15056   2 VLSTFLSLVILLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVLVMPFGAIELVNNRWIYGETFCLVRTSLDV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILGAWINGLFWALMPI-IGWASYAPDPTGATctiNWRNNDTS 185
Cdd:cd15056  82 LLTTASIMHLCCIALDRYYAICCQPLVYKMTPLRVAVMLGGCWVIPTFISFLPImQGWNHIGIEDLIAF---NCASGSTS 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  186 FV-----SYTMMVIVVNFIVPLTVMFYCYYHVSRSLRLYA---ASDCTAHLHRDWADQADVTKM-------SVIMILM-- 248
Cdd:cd15056 159 CVfmvnkPFAIICSTVAFYIPALLMVLAYYRIYVAAREQAhqiRSLQRAGSSNHEADQHRNSRMrtetkaaKTLGIIMgc 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 3024316  249 FLLAWSPYSIVCLWACFGNpKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15056 239 FCVCWAPFFVTNIVDPFIG-YRVPYLLWTAFLWLGYINSGLNPFLYAFFNKSFRRA 293
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
27-304 1.32e-20

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 89.57  E-value: 1.32e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAgitsILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNI 106
Cdd:cd15326   6 VLGAFILFA----IVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPFSATLEILGYWVFGRIFCDIWAAVDV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGMVSIGLLTVVAMDRYLTISCP-DVGRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPdPTGATCTInwrnndTS 185
Cdd:cd15326  82 LCCTASILSLCAISIDRYIGVRHSlQYPTIVTRKRAILALLGVWVLSTVISIGPLLGWKEPAP-PDDKVCEI------TE 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  186 FVSYTMMVIVVNFIVPLTVMFYCYyhvsrsLRLYAASdctahlhRDWADQADVTKMSVIMILMFLLAWSPYSIVCLWACF 265
Cdd:cd15326 155 EPFYALFSSLGSFYIPLIVILVMY------CRVYIVA-------LKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSL 221
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 3024316  266 GNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15326 222 FSHLKPPETLFKIIFWLGYFNSCLNPIIYPCSSKEFKRA 260
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
28-304 1.38e-20

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 90.01  E-value: 1.38e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   28 IAAYLIVAgITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFghAGCQIYAGLNIF 107
Cdd:cd14968   4 IVLEVLIA-VLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPLAILISLGLPTNF--HGCLFMACLVLV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  108 FGMVSIGLLTVVAMDRYLTISCPDVGRR-MTTNTYLSMILGAWINGLFWALMPIIGWASyapdptGATCTINWRNND--- 183
Cdd:cd14968  81 LTQSSIFSLLAIAIDRYLAIKIPLRYKSlVTGRRAWGAIAVCWVLSFLVGLTPMFGWNN------GAPLESGCGEGGiqc 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  184 --TSFVSYTMMViVVNF----IVPLTVM----FYCYYHVSRSLRLYAASDCTAHLHRDWADQADVTKMSVIMILMFLLAW 253
Cdd:cd14968 155 lfEEVIPMDYMV-YFNFfacvLVPLLIMlviyLRIFRVIRKQLRQIESLLRSRRSRSTLQKEVKAAKSLAIILFLFALCW 233
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 3024316  254 SPYSIVCLWACFGNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd14968 234 LPLHIINCITLFCPECKVPKILTYIAILLSHANSAVNPIVYAYRIRKFRQT 284
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
29-302 1.49e-20

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 89.92  E-value: 1.49e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   29 AAYLIVAgITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFF 108
Cdd:cd16002   5 VAYSVIV-VVSVVGNIIVMWIILAHKRMRTVTNYFLVNLAFAEASMSAFNTVINFTYAIHNEWYYGLEYCKFHNFFPIAA 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  109 GMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLsMILGAWINGLFWALmPIIGWASYAPDPTGATCTINW--RNNDTSF 186
Cdd:cd16002  84 VFASIYSMTAIALDRYMAIIHPLQPRLSATATKV-VICVIWVLAFLLAF-PQGYYSDTEEMPGRVVCYVEWpeHEERKYE 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  187 VSYTMMVIVVNFIVPLTVMFYCYYHVsrSLRLYAAS---DCTAHLHRDWADQADVTKMSVIMILMFLLAWSPYSIVCLWA 263
Cdd:cd16002 162 TVYHVCVTVLIYFLPLLVIGCAYTVV--GITLWASEipgDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPYHIYFLLQ 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 3024316  264 CFgNP----KKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFR 302
Cdd:cd16002 240 YF-HPelyeQKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFR 281
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
27-304 3.73e-20

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 88.93  E-value: 3.73e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNI 106
Cdd:cd15051   2 VLGVVLAVIILLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLGLLVLPFSAIYELRGEWPLGPVFCNIYISLDV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGMVSIGLLTVVAMDRYLTISCP-DVGRRMTTNTYLSMILGAWINGLFWALMPI-IGWAS----YAPDPTGATCTINWR 180
Cdd:cd15051  82 MLCTASILNLFAISLDRYLAITAPlRYPSRVTPRRVAIALAAIWVVSLAVSFLPIhLGWNTpdgrVQNGDTPNQCRFELN 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  181 NNdtsfvsYTMMVIVVNFIVPLTVMFYCYYHVSRSLRLYA----ASDCTAHLHRDWADQA----DVTKMSVIMILMFLLA 252
Cdd:cd15051 162 PP------YVLLVAIGTFYLPLLIMCGVYLRIFRIAREQAkrinALTPASTANSSKSAATarehKATVTLAAVLGAFIIC 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 3024316  253 WSPYSIVCLWACFGNPKKIPPSMAIIAPLFAKSSTFyNPCIYVAAHKKFRKA 304
Cdd:cd15051 236 WFPYFTYFTYRGLCGDNINETALSVVLWLGYANSAL-NPILYAFLNRDFRRA 286
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
27-304 4.36e-20

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 88.18  E-value: 4.36e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGS-WKFGHAGCQIYAGLN 105
Cdd:cd15067   1 LLGVVLSLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSILHEMTGGyWLFGRDWCDVWHSFD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  106 IFFGMVSIGLLTVVAMDRYLTISCPDVGR-RMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTGAtctinwrnNDT 184
Cdd:cd15067  81 VLASTASILNLCVISLDRYWAITDPISYPsRMTKRRALIMIALVWICSALISFPAIAWWRAVDPGPSPP--------NQC 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  185 SFVSYTMMVIV---VNFIVPLTVMFYCYYhvsrslRLYAASdctAHLHRdwadqadVTKMSVIMILMFLLAWSPYSIV-- 259
Cdd:cd15067 153 LFTDDSGYLIFsscVSFYIPLVVMLFTYY------RIYRAA---AKEQK-------AAKTLGIVMGVFILCWLPFFVTni 216
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 3024316  260 ----CLWACFGNPKKIPPsmaIIAPLFAKSSTFyNPCIYVAAHKKFRKA 304
Cdd:cd15067 217 ligfCPSNCVSNPDILFP---LVTWLGYINSGM-NPIIYACSSRDFRRA 261
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
27-303 5.00e-20

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 87.71  E-value: 5.00e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNI 106
Cdd:cd15329   2 LIGIVLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSGYWPFGEILCDVWISFDV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGMVSIGLLTVVAMDRYLTISCP-DVGRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTgaTCTInwrnndTS 185
Cdd:cd15329  82 LLCTASILNLCAISVDRYLVITRPlTYAVKRTPKRMALMIAIVWLLSALISIPPLFGWKNKVNDPG--VCQV------SQ 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  186 FVSYTMMVIVVNFIVPLTVMFYCYYHVSRSlrlyAASDCTAhlhrdwadqadVTKMSVIMiLMFLLAWSPYSIVCLWACF 265
Cdd:cd15329 154 DFGYQIYATFGAFYIPLIVMLVLYYKIYRA----AKSERKA-----------IKTLGIIM-GAFTLCWLPFFILALLRPF 217
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 3024316  266 GNPKK---IPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRK 303
Cdd:cd15329 218 LKPIKcscIPLWLSRLFLWLGYANSFLNPIIYAKFNREFRT 258
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
27-304 5.15e-20

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 88.51  E-value: 5.15e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYagLNI 106
Cdd:cd15048   2 VLAVLISVLILVTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVGLVSMPFYIPYTLTGKWPFGKVFCKAW--LVV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGMVSIGLLTVVAM--DRYLTISCPDVGRRMTTN--TYLSMILgAWINGLFWALMPIIGW---ASYAPDPTGaTCTINW 179
Cdd:cd15048  80 DYTLCTASALTIVLIslDRYLSVTKAVKYRAKQTKrrTVLLMAL-VWILAFLLYGPAIIGWdlwTGYSIVPTG-DCEVEF 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  180 RNNDTsfvsYTMMVIVVNFIVPLTVM--FYC--YYHV-SRSLRLYAASDCTAHLHRDWADQAD------------VTKMS 242
Cdd:cd15048 158 FDHFY----FTFITSVLEFFIPFISVsfFNLliYLNIrKRSRRRPLRSVPILPASQNPSRARSqreqvklrrdrkAAKSL 233
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 3024316  243 VIMILMFLLAWSPYSIVCLWACFGNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15048 234 AILVLVFLICWAPYTILTIIRSFCSGSCVDSYLYEFTFWLLWTNSAINPFLYAACHPRFRKA 295
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
38-303 6.11e-20

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 87.59  E-value: 6.11e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   38 TSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFGMVSIGLLT 117
Cdd:cd15215  12 ASLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADLLQTVLVMPWVIATSVPLFWPLDSHLCTALVVLMHLFAFAGVNTIV 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  118 VVAMDRYLTISCP-DVGRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTGATCTINWrnndTSFVSYTMMVIVV 196
Cdd:cd15215  92 VVSVDRYLAIIHPlSYPTKMTPRRGYLLIYGTWIVSVLQSTPPLYGWGQAAFDERNALCSVIW----GSSYSYTILSVVS 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  197 NFIVPLTVMFYCYYHVSRSL-RLYaasdctahlhrdwadQADVTKMSVIMILMFLLAWSPYSIVCLWACFGNpKKIPPSM 275
Cdd:cd15215 168 SFVLPVIIMLACYSMVFRAArRCY---------------HCKAAKVIFIIIFSYVLSMGPYSFLSVLAVWVD-TQVPQWV 231
                       250       260
                ....*....|....*....|....*...
gi 3024316  276 AIIAPLFAKSSTFYNPCIYVAAHKKFRK 303
Cdd:cd15215 232 ISIILWLFFLQCCIHPYIYGYMHKSIKK 259
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
32-305 9.71e-20

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 87.30  E-value: 9.71e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   32 LIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFGMV 111
Cdd:cd15214   6 IIIIAILICLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNLLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLISSA 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  112 SIGLLTVVAMDRYLTISCPDV-GRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTGATCTINWRNNdtsfVSYT 190
Cdd:cd15214  86 SMLTLGAIAIDRYYAVLYPMVyPMKITGNRAVLALVYIWLHSLIGCLPPLFGWSSLEFDRFKWMCVAAWHKE----AGYT 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  191 MMVIVVNFIVPLTVMFYCYYHVSRSLRlyaASDCTAHLhrdwadqadvtkMSVIMILMFLLAWSPYSIVCLWACFGNPKK 270
Cdd:cd15214 162 AFWQVWCALLPFVVMLVCYGFIFRVAR---ANQCKAFI------------TILVVLGAFVTTWGPYMVVISTEALWGKNS 226
                       250       260       270
                ....*....|....*....|....*....|....*
gi 3024316  271 IPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKAM 305
Cdd:cd15214 227 VSPQLETLATWLSFTSAVCHPLIYGLWNKTVRKEL 261
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
28-305 1.23e-19

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 87.29  E-value: 1.23e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   28 IAAYLIVAgITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIF 107
Cdd:cd15207   4 IVSYSLIF-LLCVVGNVLVCLVVAKNPRMRTVTNYFILNLAVSDLLVGVFCMPFTLVDNILTGWPFGDVMCKLSPLVQGV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  108 FGMVSIGLLTVVAMDRYLTISCPDVGrRMTTNTYLSMILGAWINGLF--WALMPIIGWASYAPDPTG--ATCTINWRNND 183
Cdd:cd15207  83 SVAASVFTLVAIAVDRYRAVVHPTEP-KLTNRQAFVIIVAIWVLALAimIPQALVLEVKEYQFFRGQtvHICVEFWPSDE 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  184 TSFVsYTMMVIVVNFIVPLTVMFYCYYHVSRslRLYAASDCTAHLHRDWADQAD------VTKMSVIMILMFLLAWSPYS 257
Cdd:cd15207 162 YRKA-YTTSLFVLCYVAPLLIIAVLYVRIGY--RLWFKPVPGGGSASREAQAAVskkkvrVIKMLIVVVVLFALSWLPLH 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 3024316  258 IVCLWACFGNPKkiPPSMAI-------IAPLFAKSSTFYNPCIYVAAHKKFRKAM 305
Cdd:cd15207 239 TVTMLDDFGNLS--PNQREVlyvyiypIAHWLAYFNSCVNPIVYGYFNRNFRKGF 291
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
27-305 3.92e-19

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 85.85  E-value: 3.92e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGItSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNI 106
Cdd:cd15389   3 LIVAYSIIIVI-SLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLNTPFTLVRFVNSTWVFGKIMCHLSRFAQY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGMVSIGLLTVVAMDRYLTISCPdVGRRMTTNTYLSMILGAWINGLFWALMPIIGWA----SYAPDPTGATCTINWRNN 182
Cdd:cd15389  82 CSVYVSTLTLTAIALDRHRVILHP-LKPRITPCQGVVVIAIIWIMASCLSLPHAIYQKlvefEYSNERTRSRCLPSFPEP 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  183 DTSFVSY-TMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAASDCTAHLHRDWADQAD--VTKMSVIMILMFLLAWSPYSIV 259
Cdd:cd15389 161 SDLFWKYlDLATFILQYVLPLLIIGVAYTRVAKKLWLRNAIGDVTTEQYVAQRRKKkkTIKMLMLVVLLFAICWLPLNCY 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 3024316  260 CLWACFGnPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKAM 305
Cdd:cd15389 241 HVLLSSH-PIRSNSALFFAFHWLAMSSTCYNPFIYCWLNDSFRSEL 285
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
37-304 5.27e-19

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 85.60  E-value: 5.27e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   37 ITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIgVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFGMVSIGLL 116
Cdd:cd15094  12 IVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADE-CFLIGLPFLIVTMILKYWPFGAAMCKIYMVLTSINQFTSSFTL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  117 TVVAMDRYLTISCPDVGRRMTTNTY-LSMILGAWINGlFWALMPIIGWASYAPDPTGATCTINWRNNDT--SFVSYTMMV 193
Cdd:cd15094  91 TVMSADRYLAVCHPIRSMRYRTPFIaKVVCATTWSIS-FLVMLPIILYASTVPDSGRYSCTIVWPDSSAvnGQKAFTLYT 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  194 IVVNFIVPLTVMFYCYYHVSRSLRLYAASDCTAHLHRdwaDQADVTKMSVIMILMFLLAWSPYSIVCLWACFGNPKKIPP 273
Cdd:cd15094 170 FLLGFAIPLLLISVFYTLVILRLRTVGPKNKSKEKRR---SHRKVTRLVLTVISVYIICWLPYWAFQVHLIFLPPGTDMP 246
                       250       260       270
                ....*....|....*....|....*....|....*
gi 3024316  274 S----MAIIAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15094 247 KweilMFLLLTVLSYANSMVNPLLYAFLSENFRKS 281
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
27-304 5.52e-19

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 85.24  E-value: 5.52e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNI 106
Cdd:cd15063   2 ISLLVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVDV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGMVSIGLLTVVAMDRYLTISCPDVGRR-MTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTGATCTIN--WRNND 183
Cdd:cd15063  82 WMCTASILNLCAISLDRYLAITRPIRYPSlMSTKRAKCLIAGVWVLSFVICFPPLVGWNDGKDGIMDYSGSSSlpCTCEL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  184 TSFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRLyaasdctahlhrdwadQADVTKMSVIMILMFLLAWSPYSIVCLWA 263
Cdd:cd15063 162 TNGRGYVIYSALGSFYIPMLVMLFFYFRIYRAARM----------------ETKAAKTVAIIVGCFIFCWLPFFTVYLVR 225
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 3024316  264 CFGNpKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15063 226 AFCE-DCIPPLLFSVFFWLGYCNSALNPCIYALFSRDFRFA 265
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
37-302 6.26e-19

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 85.26  E-value: 6.26e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   37 ITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFGMVSIGLL 116
Cdd:cd15391  12 FLSVGGNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALFCMPFTFTQIMLGHWVFPAPMCPIVLYVQLVSVTASVLTN 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  117 TVVAMDRYLTISCPdVGRRMTTNTYLSMILGAWING-------LFWALMPIIGWASyapdPTGATCTINWRNNDTSFVSY 189
Cdd:cd15391  92 TAIGIDRFFAVIFP-LRSRHTKSRTKCIIASIWAISfslssvqLFAGRTQRYGQYS----EGRVLCGESWPGPDTSRSAY 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  190 TMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAASDcTAHLHRDWA---DQADVTKMSVIMILMFLLAWSPYSIVCLWACFG 266
Cdd:cd15391 167 TVFVMLLTYIIPLLILTSTYGYVGFRLWNRTAPG-NADKGRDDMqikSKRKVIKMLVFVVLMFGICWLPLHLFNLVQDFS 245
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 3024316  267 N-----PKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFR 302
Cdd:cd15391 246 TvfrnmPQHTTRLIYGACHWIAMSNSFVNPIIYLFMNDSFR 286
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
26-303 1.06e-18

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 84.58  E-value: 1.06e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   26 SVIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLN 105
Cdd:cd15401   1 SVLAGVLIFTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYPYPLILLAIFHNGWTLGNIHCQISGFLM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  106 IFFGMVSIGLLTVVAMDRYLTISCPDVGRRM----TTNTYLSMilgAWINGLFwALMPIIGWASYAPDPTGATCTInwrn 181
Cdd:cd15401  81 GLSVIGSVFNITAIAINRYCYICHSLRYDKLynmkKTCCYVCL---TWVLTLA-AIVPNFFVGSLQYDPRIYSCTF---- 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  182 NDTSFVSYTMMVIVVNFIVPLTVMFYCYYHV---SRSLRLYAASDCTAHLHRdwADQADVTKMSVIMILmFLLAWSPYSI 258
Cdd:cd15401 153 AQTVSSSYTITVVVVHFIVPLSIVTFCYLRIwvlVIQVKHRVRQDSKQKLKA--NDIRNFLTMFVVFVL-FAVCWGPLNF 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 3024316  259 VCLwACFGNP----KKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRK 303
Cdd:cd15401 230 IGL-AVAINPlkvaPKIPEWLFVLSYFMAYFNSCLNAVIYGVLNQNFRK 277
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
27-305 1.49e-18

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 84.25  E-value: 1.49e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAasDLH----GSWKFGHAGCQIYA 102
Cdd:cd15204   2 VLGVVYVLIMLVCGVGNLLLIAVLARYKKLRTLTNLLIANLALSDFLVAVFCLPFEM--DYYvvrqRSWTHGDVLCAVVN 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  103 GLNIFFGMVSIGLLTVVAMDRYLTISCPDVgRRMTTNTYLSMILGAWINGLFWALmPIIGWASYAPDPTGAT--CTINWR 180
Cdd:cd15204  80 YLRTVSLYVSTNALLVIAIDRYLVIVHPLK-PRMKRRTACVVIALVWVVSLLLAI-PSAVYSKTTPYANQGKifCGQIWP 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  181 -NNDTSFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAASDCTAHLHRDWADQADVTKMSVIMIL-MFLLAWSPYSI 258
Cdd:cd15204 158 vDQQAYYKAYYLFLFVLEFVLPVLIMTLCYLRIVRKVWFRRVPGQQTEQIRRRLRRRRRKVRLLVVILtAFVLCWAPYYG 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 3024316  259 VCLWACF--GNPKKIPPSMAI--IAPLFAKSSTFYNPCIYVAAHKKFRKAM 305
Cdd:cd15204 238 YAIVRDFfpTLLSKEKLNTTIfyIVEALAMSNSMINTVVYVAFNNNIRKYL 288
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
40-304 2.68e-18

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 83.16  E-value: 2.68e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   40 ILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFGMVSIGLLTVV 119
Cdd:cd15059  15 IVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNELMGYWYFGSVWCEIWLALDVLFCTASIVNLCAI 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  120 AMDRYLTISCP-DVGRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTG-ATCTINwrnndtSFVSYTMMVIVVN 197
Cdd:cd15059  95 SLDRYWSVTQAvEYNLKRTPRRAKAMIAAVWIISAVISLPPLFGWKDEQPWHGAePQCELS------DDPGYVLFSSIGS 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  198 FIVPLTVMFYCYYHVSRSLRlyaasdctahlhrdwADQADVTKMSVIMILMFLLAWSPYSIVCLWACFGNPKKIPPSMAI 277
Cdd:cd15059 169 FYIPLLIMIIVYARIYRAAK---------------RKERRFTLVLGVVMGAFVLCWLPFFFTYPLVVVCKTCGVPELLFK 233
                       250       260
                ....*....|....*....|....*..
gi 3024316  278 IAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15059 234 FFFWLGYCNSALNPVIYTIFNKDFRRA 260
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
30-303 6.05e-18

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 83.28  E-value: 6.05e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   30 AYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGS-WKFGHAGCQIYAGLNIFF 108
Cdd:cd15005   5 TTLGLILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMASVRHGSgWIYGALSCKVIAFLAVLF 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  109 GMVSIGLLTVVAMDRYLTISCPDV-GRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTGATCTINWR---NNDT 184
Cdd:cd15005  85 CFHSAFTLFCIAVTRYMAIAHHRFyAKRMTFWTCLAVICMAWTLSVAMAFPPVFDVGTYTFIREEDQCTFEHRsykANDT 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  185 -SFVSYTMMVIVVNFIVPLTVMFYCYYH-----------VSRSLRLY-------AASDCTA------------------- 226
Cdd:cd15005 165 lGFMLVLAVVIAATHLVYLKLLIFLRHHrkmkpaqlvpaISQNWTFHgpgatgqAAANWTAgfgrgptpptllgirqafh 244
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  227 ------HLHRDWADQADVTKMSVIMILMFLLAWSPYSIVCLWACFGNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKK 300
Cdd:cd15005 245 sgarrlLVLDEFKMEKRLTRMFYAITLLFLLLWSPYIVACYIRVFVRGYAVPQGFLTAAVWMTFAQAGVNPIVCFFFNRE 324

                ...
gi 3024316  301 FRK 303
Cdd:cd15005 325 LRK 327
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
20-304 6.07e-18

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 82.28  E-value: 6.07e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   20 FSRTEHSVIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQ 99
Cdd:cd15321   1 YSVQATAAIAAAITFLILFTIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFRKTWCE 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  100 IYAGLNIFFGMVSIGLLTVVAMDRYLTIS-CPDVGRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTG-ATCTI 177
Cdd:cd15321  81 IYLALDVLFCTSSIVHLCAISLDRYWSVSrAIEYNSKRTPRRIKCIILIVWLIAAVISLPPLIYKGKQKDEQGGlPQCKL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  178 N---WrnndtsfvsYTMMVIVVNFIVPLTVMFYCYyhvsrsLRLYAASDctahlhrdwADQADVTKMSVIMILMFLLAWS 254
Cdd:cd15321 161 NeeaW---------YILSSSIGSFFAPCLIMILVY------LRIYLIAK---------NREKRFTFVLAVVIGVFVLCWF 216
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 3024316  255 P----YSI--VCLWACfgnpkKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15321 217 PfffsYSLgaICPELC-----KVPHSLFQFFFWIGYCNSSLNPVIYTIFNQDFRRA 267
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
27-305 6.15e-18

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 82.46  E-value: 6.15e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSILSNVVVLGIFI--KYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGL 104
Cdd:cd15002   1 LVPILLGVICLLGFAGNLMVIGILLnnARKGKPSLIDSLILNLSAADLLLLLFSVPFRAAAYSKGSWPLGWFVCKTADWF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  105 NIFFGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILGAWingLFWALMPIIGWA--SYAPDPTGATCTINWRnn 182
Cdd:cd15002  81 GHACMAAKSFTIAVLAKACYMYVVNPTKQVTIKQRRITAVVASIW---VPACLLPLPQWLfrTVKQSEGVYLCILCIP-- 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  183 dtsFVSYTMMVIVVN------FIVPLTVMFYCYYHVSRSLRlyAASDCTAHLhRDWADQADVTKMSVIMILMFLLAWSPY 256
Cdd:cd15002 156 ---PLAHEFMSAFVKlyplfvFCLPLTFALFYFWRAYGQCQ--RRGTKTQNL-RNQIRSRKLTHMLLSVVLAFTILWLPE 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 3024316  257 SIVCLWACFGNPKKIPPSMAII--APLFAKSSTFYNPCIYVAAHKKFRKAM 305
Cdd:cd15002 230 WVAWLWLIHIKSSGSSPPQLFNvlAQLLAFSISSVNPIIFLLMSEEFREGF 280
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
33-304 1.19e-17

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 81.21  E-value: 1.19e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   33 IVAGITSILS---NVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFG 109
Cdd:cd15049   5 IATGSLSLVTvggNILVILSFRVNRQLRTVNNYFLLSLACADLIIGLVSMNLYTVYLVMGYWPLGPLLCDLWLALDYVAS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  110 MVSIGLLTVVAMDRYLTISCPDVGR-RMTTNTYLSMILGAW-INGLFWALmPIIGW---ASYAPDPTGAtCTINWRNNdt 184
Cdd:cd15049  85 NASVMNLLLISFDRYFSVTRPLTYRaKRTPKRAILMIALAWvISFVLWAP-AILGWqyfVGERTVPDGQ-CYIQFLDD-- 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  185 sfVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLrlyaasdctahlhrdwADQADVTKMSVIMILMFLLAWSPYSIVCLWAC 264
Cdd:cd15049 161 --PAITFGTAIAAFYLPVLVMTILYWRIYRET----------------ARERKAARTLSAILLAFIITWTPYNILVLVST 222
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 3024316  265 FGnPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15049 223 FC-AKCIPDTLWSFGYWLCYINSTINPFCYALCNKTFRKT 261
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
27-304 1.20e-17

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 81.11  E-value: 1.20e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAgitsILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNI 106
Cdd:cd15327   6 FLAIFILMA----IVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLPFSATLEVLGFWAFGRVFCDIWAAVDV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGMVSIGLLTVVAMDRYLTIS-CPDVGRRMTTNTYLSMILGAWINGLFWALMPIIGWASyAPDPTGATCTInwrnndTS 185
Cdd:cd15327  82 LCCTASILSLCVISVDRYVGVKhSLKYPTIMTERKAGVILVLLWVSSMVISIGPLLGWKE-PPPPDESICSI------TE 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  186 FVSYTMMVIVVNFIVPLTVMFYCYYhvsrslRLYAASdctahlhRDWADQADVTKMSVIMILMFLLAWSPYSIVCLWACF 265
Cdd:cd15327 155 EPGYALFSSLFSFYLPLMVILVMYF------RVYVVA-------LKFSREKKAAKTLAIVVGVFILCWFPFFFVLPLGSF 221
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 3024316  266 GNPKKipPSMAIIAPLF--AKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15327 222 FPALK--PSEMVFKVIFwlGYFNSCVNPIIYPCSSKEFKRA 260
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
27-304 1.33e-17

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 81.09  E-value: 1.33e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGItsiLSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNI 106
Cdd:cd15325   5 VILGGFILFGV---LGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGMVSIGLLTVVAMDRYLTISCP-DVGRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTgATCTInwrnndTS 185
Cdd:cd15325  82 LCCTASIMSLCIISIDRYIGVSYPlRYPSIMTERRGLLALLCVWVLSLVISIGPLFGWKEPAPEDE-TICQI------TE 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  186 FVSYTMMVIVVNFIVPLTVMFYCYYhvsrslRLYAASdctahlhRDWADQADVTKMSVIMILMFLLAWSPYSIVCLWACF 265
Cdd:cd15325 155 EPGYALFSALGSFYLPLAIILVMYC------RVYVVA-------LKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSI 221
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 3024316  266 GNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15325 222 FPAYKPSDTVFKITFWLGYFNSCINPIIYPCSSQEFKKA 260
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
28-304 1.78e-17

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 81.43  E-value: 1.78e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   28 IAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIF 107
Cdd:cd15403   3 LAIVMILMIAIGFLGNAIVCLIVYQKPAMRSAINLLLATLAFSDIMLSLLCMPFTAVTIITVDWHFGAHFCRISAMLYWF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  108 FGMVSIGLLTVVAMDRYLTIscpdVGRRMTTNTYLS--MILGAWINGLFWALMPIIGWASYAPDPTGATCTINWRNNDTS 185
Cdd:cd15403  83 FVLEGVAILLIISVDRFLII----VQRQDKLNPHRAkvMIAISWVLSFCISFPSVVGWTLVEVPARAPQCVLGYTESPAD 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  186 FVsYTMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAASdctAHLHRDWADQADVTKM----------------------SV 243
Cdd:cd15403 159 RV-YAVLLVVAVFFVPFSIMLYSYLCILNTVRRNAVR---IHNHADSLCLSQVSKLglmglqrphqmnvdmsfktrafTT 234
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 3024316  244 IMILM--FLLAWSPYSIVCLWACFGNPKKIPPSMAIIAPL---FAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15403 235 ILILFvgFSLCWLPHTVFSLLSVFSRRFYYSSSFYPISTCvlwLSYLKSVFNPVIYCWRIKKFREA 300
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
27-259 2.98e-17

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 80.58  E-value: 2.98e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIgVSSIGYPMSAASDLHGSWKFGHAGCQIYA---G 103
Cdd:cd15093   2 LIPCIYAVVCLVGLCGNSLVIYVVLRYAKMKTVTNIYILNLAIADE-LFMLGLPFLAASNALRHWPFGSVLCRLVLsvdG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  104 LNIFfgmVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMI-LGAWINGLFwALMPIIGWASYAPDPTGA-TCTINWRN 181
Cdd:cd15093  81 INMF---TSIFCLTVMSVDRYLAVVHPIKSARWRRPRVAKVVnLAVWVASLL-VILPVVVFAGTRENQDGSsACNMQWPE 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  182 ND----TSFVSYTMmviVVNFIVPLTVMFYCYYHVSRSLRLYAASDCTAHLHRDwadQADVTKMSVIMILMFLLAWSPYS 257
Cdd:cd15093 157 PAaawsAGFIIYTF---VLGFLLPLLIICLCYLLIVIKVKSAGLRAGWQQRKRS---ERKVTRMVVMVVVVFVICWLPFY 230

                ..
gi 3024316  258 IV 259
Cdd:cd15093 231 VL 232
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
26-293 4.80e-17

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 79.97  E-value: 4.80e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   26 SVIAAYLIVAGItsiLSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLN 105
Cdd:cd15123   4 YVTYAVIISVGI---LGNAILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTCVPVDATRYIADTWLFGRIGCKLLSFIQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  106 IFFGMVSIGLLTVVAMDRYLTISCPdvGRRMTTNTYLSMILGA---WINGLFWALMPIIGWASYA-PDP----TGATCTI 177
Cdd:cd15123  81 LTSVGVSVFTLTVLSADRYRAIVKP--LELQTSDAVLKTCCKAgcvWIVSMLFAIPEAVFSDLYSfRDPekntTFEACAP 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  178 NWRNNDTSFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSL---RLYAASDCTAHLHRDWADQADVTKMSVIMILMFLLAWS 254
Cdd:cd15123 159 YPVSEKILQEIHSLLCFLVFYIIPLSIISVYYFLIARTLyksTFNMPAEEHSHARKQIESRKRVAKTVLVLVALFAFCWL 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 3024316  255 PYSIVCLWACFGNPKKIPPS-MAIIAPLFAKSSTFYNPCI 293
Cdd:cd15123 239 PNHILYLYRSFTYHTSVDSSaFHLIATIFSRVLAFSNSCV 278
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
27-304 4.94e-17

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 79.45  E-value: 4.94e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNI 106
Cdd:cd15333   6 SLAVLLALITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMPISIVYTVTGTWTLGQVVCDIWLSSDI 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGMVSIGLLTVVAMDRYLTIS-CPDVGRRMTTNTYLSMILGAWINGLFWALMPIIgWASYAPDPTGATCTINwrnndTS 185
Cdd:cd15333  86 TCCTASILHLCVIALDRYWAITdAVEYSKKRTPKRAAVMIALVWVISISISLPPFF-WRQAKAEEEVSECVVN-----TD 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  186 FVSYTMMVIVVNFIVPlTVMFYCYYHvsrslRLYAASDctahlhrdwADQADVTKMSVIMILMFLLAWSPYSIVCL-WAC 264
Cdd:cd15333 160 HILYTVYSTVGAFYIP-TLLLIALYG-----RIYVEAR---------ARERKATKTLGIILGAFIVCWLPFFIISLvLPI 224
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 3024316  265 FGNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15333 225 CKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQA 264
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
27-303 5.62e-17

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 79.57  E-value: 5.62e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAgITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIgVSSIGYPMSAASDLHGsWKFGHAGCQIYAGL-- 104
Cdd:cd14984   3 LPVLYSLVF-LLGLVGNSLVLLVLLYYRKLRSMTDVYLLNLALADL-LFVLTLPFWAVYAADG-WVFGSFLCKLVSALyt 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  105 -NIFFGMVsigLLTVVAMDRYLTISCPDVGRRMTTNTYLSMI-LGAWINGLFWALmPIIGWASYAPDPTGATCTINWRNN 182
Cdd:cd14984  80 iNFYSGIL---FLACISIDRYLAIVHAVSALRARTLLHGKLTcLGVWALALLLSL-PEFIFSQVSEENGSSICSYDYPED 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  183 DTSFVSYTMMV--IVVNFIVPLTVMFYCYYHVSRSLRlyAASdctaHLHRDWAdqadvTKMSVIMILMFLLAWSPYSIVC 260
Cdd:cd14984 156 TATTWKTLLRLlqNILGFLLPLLVMLFCYSRIIRTLL--RAR----NHKKHRA-----LRVIFAVVVVFFLCWLPYNIVL 224
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 3024316  261 LWACFGNPKKIPPSMAI-----IAPLFAKSSTFY----NPCIYVAAHKKFRK 303
Cdd:cd14984 225 LLDTLQLLGIISRSCELsksldYALQVTESLAFShcclNPVLYAFVGVKFRK 276
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
39-304 5.69e-17

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 79.25  E-value: 5.69e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   39 SILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFGMVSIGLLTV 118
Cdd:cd15330  14 AIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCA 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  119 VAMDRYLTISCP-DVGRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTGATCTINWRNndtsfvSYTMMVIVVN 197
Cdd:cd15330  94 IALDRYWAITDPiDYVNKRTPRRAAVLISLTWLIGFSISIPPMLGWRTPEDRSDPDACTISKDP------GYTIYSTFGA 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  198 FIVPLTVMFYCYYhvsrslRLYAASdctahlhrdwADQADVTKMSVIMILMFLLAWSPYSIVCLWACFGNPK-KIPPSMA 276
Cdd:cd15330 168 FYIPLILMLVLYG------RIFKAA----------ARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESTcHMPELLG 231
                       250       260
                ....*....|....*....|....*...
gi 3024316  277 IIAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15330 232 AIINWLGYSNSLLNPIIYAYFNKDFQSA 259
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
28-304 9.22e-17

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 78.97  E-value: 9.22e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   28 IAAYLIVAgITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAglnIF 107
Cdd:cd15206   4 IPLYSVIF-LLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFCMPFTLVGQLLRNFIFGEVMCKLIP---YF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  108 FGM-VSIGLLTVVA--MDRYLTISCPDVGRRMTTNTY-LSMILGAWINGLFWaLMPIIGWASYAP--DPTGATCTINWrN 181
Cdd:cd15206  80 QAVsVSVSTFTLVAisLERYFAICHPLKSRVWQTLSHaYKVIAGIWLLSFLI-MSPILVFSNLIPmsRPGGHKCREVW-P 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  182 NDTSFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLrlyaasdctahlhrdWADQADVTKMSVIMILMFLLAWSPYSIVCL 261
Cdd:cd15206 158 NEIAEQAWYVFLDLMLLVIPGLVMSVAYGLISWTL---------------LEAKKRVIRMLFVIVVEFFICWTPLYVINT 222
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 3024316  262 WACFGNP---KKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15206 223 WKAFDPPsaaRYVSSTTISLIQLLAYISSCVNPITYCFMNKRFRQA 268
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
37-303 1.29e-16

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 78.60  E-value: 1.29e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   37 ITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTD--IGVSSIGYPMSAAsdLHGSWKFGHAGCQIYAGLNIFFGMVSIG 114
Cdd:cd15393  12 LVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADiiIGLFSIPFQFQAA--LLQRWVLPRFMCPFCPFVQVLSVNVSVF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  115 LLTVVAMDRYLTISCPdVGRRMTTNTYLSMILGAWINGLFWAL-MPIIGWASYAPDPTGAT----CTINWRNNDTsFVSY 189
Cdd:cd15393  90 TLTVIAVDRYRAVIHP-LKARCSKKSAKIIILIIWILALLVALpVALALRVEELTDKTNNGvkpfCLPVGPSDDW-WKIY 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  190 TMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAASDCTAHLHRDWADQA--DVTKMSVIMILMFLLAWSPYSIVCLWAcFGN 267
Cdd:cd15393 168 NLYLVCVQYFVPLVIICYAYTRIAVKIWGTKAPGNAQDVRDDEILKNkkKVIKMLIIVVALFALCWLPLQTYNLLN-EIK 246
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 3024316  268 PkKIPPSMAIIAPLF-----AKSSTFYNPCIYVAAHKKFRK 303
Cdd:cd15393 247 P-EINKYKYINIIWFcshwlAMSNSCYNPFIYGLYNEKFKR 286
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
29-304 1.31e-16

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 79.28  E-value: 1.31e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   29 AAYLIVAGITSILSNVVVLGIFIKYKELRTP-TNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGhAGCQIYAGLNIF 107
Cdd:cd15320   5 GCFLSVLILSTLLGNTLVCAAVIRFRHLRSKvTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFG-SFCNIWVAFDIM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  108 FGMVSIGLLTVVAMDRYLTISCP-DVGRRMTTNTYLSMILGAWINGLFWALMPI-IGWASYAP----DPTGATCTINWRN 181
Cdd:cd15320  84 CSTASILNLCVISVDRYWAISSPfRYERKMTPKVAFIMISVAWTLSVLISFIPVqLNWHKAKPtsflDLNASLRDLTMDN 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  182 NDTSF-VSYTMMVIVVNFIVPLTVMFYCYYHVSR----SLRLYAA-----------------------SDCTAHLHRDWA 233
Cdd:cd15320 164 CDSSLnRTYAISSSLISFYIPVAIMIVTYTRIYRiaqkQIRRISAleraavhakncqnstgnrgsgdcQQPESSFKMSFK 243
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 3024316  234 DQADVTKMSVIMILMFLLAWSPYSIVCLWACFGNPKK-----IPPSMAIIAPLFAKSSTFYNPCIYvAAHKKFRKA 304
Cdd:cd15320 244 RETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCKPTStepfcISSTTFDVFVWFGWANSSLNPIIY-AFNADFRKA 318
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
26-304 1.57e-16

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 78.05  E-value: 1.57e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   26 SVIAAYLIVagiTSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLN 105
Cdd:cd15323   4 AAVVGFLIV---FTIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMGYWYFGQVWCNIYLALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  106 IFFGMVSIGLLTVVAMDRYLTIS-CPDVGRRMTTNTYLSMILGAWINGLFWALMPIIgwaSYAPDPTGATCTINWRNNDT 184
Cdd:cd15323  81 VLFCTSSIVHLCAISLDRYWSVTqAVEYNLKRTPRRVKAIIVTVWLISAVISFPPLI---SMYRDPEGDVYPQCKLNDET 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  185 SFVSYTMmviVVNFIVPLTVMFYCYyhvsrsLRLYAASDctahlhrdwADQADVTKMSVIMILMFLLAWSP----YSI-- 258
Cdd:cd15323 158 WYILSSC---IGSFFAPCLIMILVY------IRIYRVAK---------AREKRFTFVLAVVMGVFVVCWFPfffsYSLyg 219
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 3024316  259 VCLWACfgnpkKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15323 220 ICREAC-----EVPEPLFKFFFWIGYCNSSLNPVIYTIFNQDFRRS 260
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
27-304 4.91e-16

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 76.76  E-value: 4.91e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNI 106
Cdd:cd15062   2 VVGVALGAFILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFSATLEVLGYWAFGRIFCDVWAAVDV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGMVSIGLLTVVAMDRYLTISCP-DVGRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPdPTGATCTINWRNndts 185
Cdd:cd15062  82 LCCTASIMSLCVISVDRYIGVRYPlNYPTIVTARRATVALLIVWVLSLVISIGPLLGWKEPAP-ADEQACGVNEEP---- 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  186 fvSYTMMVIVVNFIVPLTVMFYCYYHVSRslrlyaasdctahLHRDWADQADVTKMSVIMILMFLLAWSPYSIVCLWACF 265
Cdd:cd15062 157 --GYVLFSSLGSFYLPLAIILVMYCRVYV-------------VAFKFSREKKAAKTLGIVVGAFVLCWFPFFVVLPLGSL 221
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 3024316  266 GNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15062 222 FSTLKPPEPVFKVVFWLGYFNSCLNPIIYPCSSREFKRA 260
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
27-304 5.17e-16

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 77.03  E-value: 5.17e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSsIGYPMSAASD-LHGSWKFGHAGCQIYAGLn 105
Cdd:cd14985   2 VIPALYIAIFLVGLLGNLFVVWVFLFPRGPKRVADIFIANLAAADLVFV-LTLPLWATYTaNQYDWPFGAFLCKVSSYV- 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  106 IFFGM-VSIGLLTVVAMDRYLTISCPDVGRRMTTntylsMILGAWINGLFWAL-----MPIIGWASYAPDP-TGATCTIN 178
Cdd:cd14985  80 ISVNMfASIFLLTCMSVDRYLAIVHPVASRRLRR-----RRQARVTCALIWVVacllsLPTFLLRSLQAIEnLNKTACIM 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  179 WRNNDTSFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRlyAASDCTAHLHRdwaDQADVTKMSVIMILMFLLAWSPYSI 258
Cdd:cd14985 155 LYPHEAWHFGLSLELNILGFVLPLLIILTCYFHIARSLR--KRYERTGKNGR---KRRKSLKIIFALVVAFLVCWLPFHF 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 3024316  259 VCLWACFGNPKKI---PPSMAI-----IAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd14985 230 FKFLDFLAQLGAIrpcFWELFLdlglpIATCLAFTNSCLNPFIYVFVDRRFRQK 283
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
27-293 6.97e-16

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 76.91  E-value: 6.97e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNI 106
Cdd:cd15125   2 VIPSLYLLIITVGLLGNITLVKIFITNSAMRSVPNIFISSLAAGDLLLLVTCVPVDASRYFYEEWMFGTVGCKLIPVIQL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGMVSIGLLTVVAMDRYLTISCP-DVGRRMTTNTYLSMILGAWINGLFWALmPIIGWASYA----PDPTGATCTINW-R 180
Cdd:cd15125  82 TSVGVSVFTLTALSADRYKAIVNPmDIQTSSAVLRTCLKAIAIWVVSVLLAV-PEAVFSEVAhimpDDNTTFTACIPYpQ 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  181 NNDTSFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRLYA---ASDCTAHLHRDWADQADVTKMSVIMILMFLLAWSPYS 257
Cdd:cd15125 161 TDEMHPKIHSVLIFLVYFLIPLAIISIYYYHIAKTLIKSAhniPGEYSEHSKRQMETRKRLAKIVLVFVGLFAFCWFPNH 240
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 3024316  258 IVCLWACFgNPKKIPPSMA-IIAPLFAKSSTFYNPCI 293
Cdd:cd15125 241 VLYMYRSF-NYNEIDSSLGhMIVTLVARVLSFCNSCV 276
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
29-261 7.01e-16

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 76.74  E-value: 7.01e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   29 AAYLIVAgITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIgVSSIGYPMSAASDLHGSWkFGHAGCQIYAGL---N 105
Cdd:cd15177   5 CVYLVVF-VLGLVGNGLVLATHTRYRRLRSMTDVYLLNLALADL-LLLLTLPFAAAETLQGWI-FGNAMCKLIQGLyaiN 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  106 IFFGMVsigLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILGA---WINGLFWALmPIIGWASYAPDPTGATCTINWR-- 180
Cdd:cd15177  82 FYSGFL---FLTCISVDRYVVIVRATSAHRLRPKTLFYSVLTSlivWLLSILFAL-PQLIYSRVENRSELSSCRMIFPev 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  181 NNDTSFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLrlyaasdctahLHRDWADQADVTKMSVIMILMFLLAWSPYSIVC 260
Cdd:cd15177 158 VSRTVKGATALTQVVLGFAIPLIVMAVCYAAIGRTL-----------LAARGWERHRALRVIAALVVAFVLFQLPYSVVL 226

                .
gi 3024316  261 L 261
Cdd:cd15177 227 L 227
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
27-303 7.39e-16

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 76.34  E-value: 7.39e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIgVSSIGYPMSA---ASDlhGSWKFGHAGCQIYAG 103
Cdd:cd15088   2 IMPSVFGCICVVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADL-LFMLGMPFLIhqfAID--GQWYFGEVMCKIITA 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  104 LNIFFGMVSIGLLTVVAMDRYLTISCPdvgrrMTTNTYLSMILGAWINGLFWAL-----MPIIGWASYAPDPTGAT-CTI 177
Cdd:cd15088  79 LDANNQFTSTYILTAMSVDRYLAVVHP-----IRSTKYRTRFVAKLVNVGLWAAsflsiLPVWVYSSLIYFPDGTTfCYV 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  178 NWrNNDTSFVSYTMMVIVVNFIVPLTVMFYCYYHV-SRSLRLYAASDCTAHLHRdwadQADVTKMSVIMILMFLLAWSPY 256
Cdd:cd15088 154 SL-PSPDDLYWFTIYHFILGFAVPLVVITVCYILIlHRLARGVAPGNQSHGSSR----TKRVTKMVILIVVVFIVCWLPF 228
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 3024316  257 SIVCLWacfgNPKKIPPSMAIIAPLFAKSSTFY-----NPCIYVAAHKKFRK 303
Cdd:cd15088 229 HVVQLV----NLAMNRPTLAFEVAYFLSICLGYansclNPFVYILVSENFRK 276
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
26-303 1.07e-15

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 76.04  E-value: 1.07e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   26 SVIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLN 105
Cdd:cd15400   1 TALSSVLIFTTVVDILGNLLVIISVFRNRKLRNSGNVFVVSLALADLVVALYPYPLVLVAIFHNGWALGEMHCKVSGFVM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  106 IFFGMVSIGLLTVVAMDRYLTI----SCPDVGRRMTTNTYLSMIlgaWINGLFwALMPIIGWASYAPDPTGATCTInwrn 181
Cdd:cd15400  81 GLSVIGSIFNITGIAINRYCYIchsfAYDKLYSRWNTLLYVCLI---WALTVV-AIVPNFFVGSLEYDPRIYSCTF---- 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  182 NDTSFVSYTMMVIVVNFIVPLTVMFYCYYHV---SRSLRLYAASDCTAHLHRdwADQADVTKMSVIMILmFLLAWSPYSI 258
Cdd:cd15400 153 VQTASSSYTIAVVVIHFIVPITVVSFCYLRIwvlVIQVRRKVKSESKPRLKP--SDFRNFLTMFVVFVI-FAICWAPLNL 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 3024316  259 VCLwACFGNPK----KIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRK 303
Cdd:cd15400 230 IGL-AVAINPQemapKVPEWLFVVSYFMAYFNSCLNAIIYGLLNQNFRK 277
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
40-304 1.64e-15

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 75.63  E-value: 1.64e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   40 ILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFGMVSIGLLTVV 119
Cdd:cd15399  15 VVGNSLVIYVVIKFKNMRTVTNFFIANLAVADLMVNTLCLPFTLVYTLLDEWKFGAVLCHLVPYAQALAVHVSTVTLTVI 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  120 AMDRYLTIsCPDVGRRMTTNTYLSMILGAW-INGLFWALMPIIGWASY---APDPTGATCTINWRNNDTSF-VSYTMMVI 194
Cdd:cd15399  95 ALDRHRCI-VYHLESKISKKISFLIIGLTWaASALLASPLAIFREYSVieiSPDFKIQACSEKWPNGTLNDgTIYSVSML 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  195 VVNFIVPLTVMFYCYYHVSRSLRLYAASDCTA--HLHRdwadQADVTKMSVIMILMFLLAWSPYSIVCLWACFGNPKKIP 272
Cdd:cd15399 174 LIQYVLPLAIISYAYIRIWTKLKNHVSPGGGNdhYHQR----RRKTTKMLVCVVVVFAVSWLPFHAFQLASDIDSKVLDL 249
                       250       260       270
                ....*....|....*....|....*....|....*
gi 3024316  273 PSMAIIAPLF---AKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15399 250 KEYKLIYTIFhviAMCSTFANPLLYGWMNNNYRTA 284
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
37-304 1.73e-15

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 75.10  E-value: 1.73e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   37 ITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFGMVSIGLL 116
Cdd:cd15066  11 LAAIFGNLLVIISVMRHRKLRVITNYFVVSLAMADMLVALCAMTFNASVEITGRWMFGYFMCDVWNSLDVYFSTASILHL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  117 TVVAMDRYLTISCP-DVGRRMTTNTYLSMILGAWINGLFWALMPI-IGWASyapdpTGATCTINWRNNDT-SFV---SYT 190
Cdd:cd15066  91 CCISVDRYYAIVQPlEYPSKMTKRRVAIMLANVWISPALISFLPIfLGWYT-----TEEHLQYRKTHPDQcEFVvnkIYA 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  191 MMVIVVNFIVPLTVMFYCYYHVSRSlrlyaasdctAHLHRDWAdqadvtKMSVIMILMFLLAWSPY------SIVCLWAC 264
Cdd:cd15066 166 LISSSVSFWIPCIVMIFTYYRIYLE----------AKREHKAA------KTLGIIMGAFILCWLPFflwyvtTTLCGDAC 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 3024316  265 fgnpkKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15066 230 -----PYPPILVSILFWIGYFNSTLNPLIYAYFNRDFREA 264
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
27-303 1.80e-15

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 75.38  E-value: 1.80e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIgYPMSAASDLHGSWKFGHAGCQIYAGLNI 106
Cdd:cd15091   2 IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTT-MPFQSTVYLMNSWPFGDVLCKIVISIDY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMI-LGAWINGLFWALMPIIGWASYAPDPTGAT-CTINWRNNDT 184
Cdd:cd15091  81 YNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIInICIWLLSSSVGISAIVLGGTKVREDVDSTeCSLQFPDDDY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  185 SF--VSYTMMVIVVNFIVPLTVMFYCYYHVsrSLRLYAASDCTAHLHRDwADQADVTKMSVIMILMFLLAWSPYSIVCLW 262
Cdd:cd15091 161 SWwdTFMKICVFIFAFVIPVLIIIVCYTLM--ILRLKSVRLLSGSREKD-RNLRRITRLVLVVVAVFVVCWTPIHIFILV 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 3024316  263 ACFGNpkkIPPSMAIIAPLF-----AKSSTFYNPCIYVAAHKKFRK 303
Cdd:cd15091 238 EALGS---VSHSTAAVSSYYfcialGYTNSSLNPILYAFLDENFKR 280
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
27-303 2.03e-15

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 75.16  E-value: 2.03e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAgITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDL-HGSWKFGHAGCQIYAGLN 105
Cdd:cd15394   3 IIPLYSLVV-LVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLAYAFePRGWVFGRFMCYFVFLMQ 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  106 IFFGMVSIGLLTVVAMDRYLTISCPdVGRRMttntylSMILGAWINGLFWAL-----MPIIGWASYA--PDPTGATCTIN 178
Cdd:cd15394  82 PVTVYVSVFTLTAIAVDRYYVTVYP-LRRRI------SRRTCAYIVAAIWLLscglaLPAAAHTYYVefKGLDFSICEEF 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  179 WRNNDTSFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAASDCTAHLHRDW--ADQADVTKMSVIMILMFLLAWSPY 256
Cdd:cd15394 155 WFGQEKQRLAYACSTLLITYVLPLLAISLSYLRISVKLRNRVVPGSMTQSQAEWdrARRRKTFRLLVVVVVAFAICWLPL 234
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 3024316  257 SIVCLWacfgnpKKIPPSMA---------IIAPLFAKSSTFYNPCIYVAAHKKFRK 303
Cdd:cd15394 235 HIFNVI------RDIDIDLIdkqyfnliqLLCHWLAMSSACYNPFLYAWLHDSFRG 284
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
32-304 2.32e-15

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 74.97  E-value: 2.32e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   32 LIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFGMV 111
Cdd:cd15314   7 LGLISLVTVCGNLLVIISIAHFKQLHTPTNYLILSLAVADLLVGGLVMPPSMVRSVETCWYFGDLFCKIHSSFDITLCTA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  112 SIGLLTVVAMDRYLTISCPDVGR-RMTTNTYLSMILGAW-INGLFWALMPI----IGWASYAPDPTGATCTInwrnnDTS 185
Cdd:cd15314  87 SILNLCFISIDRYYAVCQPLLYRsKITVRVVLVMILISWsVSALVGFGIIFlelnIKGIYYNHVACEGGCLV-----FFS 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  186 FVSYTMMViVVNFIVPLTVMFYCY---YHV----SRSLRLYAASdctahlhrdwaDQADVTKMS-------VIMILMFLL 251
Cdd:cd15314 162 KVSSVVGS-VFSFYIPAVIMLCIYlkiFLVaqrqARSIQSARTK-----------SGASSSKMErkatktlAIVMGVFLL 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 3024316  252 AWSPYSIVCLWACFGNpKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15314 230 CWTPFFLCNIIDPFIN-YSIPPVLIEVLNWLGYSNSTLNPFIYAFFYSWFRKA 281
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
34-304 2.69e-15

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 74.95  E-value: 2.69e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   34 VAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDiGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFGMVSI 113
Cdd:cd15970   9 VVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIAD-ELLMLSVPFLVTSTLLRHWPFGSLLCRLVLSVDAINMFTSI 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  114 GLLTVVAMDRYLTISCPDVGRRMTTNTYLSMI-LGAWINGLFwALMPIIGWASYAPDPTGA-TCTINWRNNDTS----FV 187
Cdd:cd15970  88 YCLTVLSIDRYIAVVHPIKAARYRRPTVAKMVnLGVWVFSIL-VILPIIIFSNTAPNSDGSvACNMQMPEPSQRwlavFV 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  188 SYTMMvivVNFIVPLTVMFYCYYHVSRSLRLYAASdctAHLHRDWADQADVTKMSVIMILMFLLAWSPYSIVCLWACFGN 267
Cdd:cd15970 167 VYTFL---MGFLLPVIAICLCYILIIVKMRVVALK---AGWQQRKRSERKITLMVMMVVTVFVICWMPFYVVQLVSVFVG 240
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 3024316  268 PKKIPPSMAIIAPLFAKSSTfyNPCIYVAAHKKFRKA 304
Cdd:cd15970 241 QHDATVSQLSVILGYANSCA--NPILYGFLSDNFKRS 275
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
27-304 3.65e-15

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 74.49  E-value: 3.65e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIgVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNI 106
Cdd:cd15971   2 FLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTVTNIYILNLAIADE-LFMLGLPFLAIQVALVHWPFGKAICRVVMTVDG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILGA-WINGLFwALMPIIGWASYAPDPTGATCTINW-RNNDT 184
Cdd:cd15971  81 INQFTSIFCLTVMSIDRYLAVVHPIKSAKWRKPRTAKMINMAvWGVSLL-VILPIMIYAGVQTKHGRSSCTIIWpGESSA 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  185 SFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRlyaASDCTAHLHRDWADQADVTKMSVIMILMFLLAWSPYSIVCLWAC 264
Cdd:cd15971 160 WYTGFIIYTFILGFFVPLTIICLCYLFIIIKVK---SSGIRVGSSKRKKSEKKVTRMVSIVVAVFVFCWLPFYIFNVSSV 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 3024316  265 FG--NPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15971 237 SVsiSPTPGLKGMFDFVVVLSYANSCANPILYAFLSDNFKKS 278
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
30-304 3.68e-15

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 74.22  E-value: 3.68e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   30 AYLIVAgitSILSNVVVLGIFIKYKEL-RTPTNaVIINLAFTDIGVSSIGYPMSAASDLHGS-WKFGHAGCQIYAGLNIF 107
Cdd:cd15328   8 AMLVVA---TFLWNLLVLVTILRVRTFhRVPHN-LVASMAVSDVLVAALVMPLSLVHELSGRrWQLGRSLCQVWISFDVL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  108 FGMVSIGLLTVVAMDRYLTIS----CPDVGRRMTTNTylsMILGAWINGLFWALMPII-GWA-SYAPDptGATCTINWRN 181
Cdd:cd15328  84 CCTASIWNVTAIALDRYWSITrhleYTLRTRRRISNV---MIALTWALSAVISLAPLLfGWGeTYSED--SEECQVSQEP 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  182 ndtsfvSYTMMVIVVNFIVPLTVMFYCYYhvsrslRLYAASDctahlhrdwaDQADVTKMSVIMILMFLLAWSPYS---- 257
Cdd:cd15328 159 ------SYTVFSTFGAFYLPLCVVLFVYW------KIYKAAQ----------KEKRAALMVGILIGVFVLCWIPFFltel 216
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 3024316  258 IVCLWACfgnpkKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15328 217 ISPLCSC-----DIPPIWKSIFLWLGYSNSFFNPLIYTAFNKNYNNA 258
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
32-298 4.01e-15

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 74.40  E-value: 4.01e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   32 LIVAGITSILS---NVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFF 108
Cdd:cd15384   4 IVVLAVMFVISfigNLLTIIQIYRLRRSRRTIYSLLLHLAIADLLVTFFCIPSEAIWAYTVAWLAGNTMCKLVKYLQVFG 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  109 GMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYlSMILGAWINGLFWALMPIIGW--ASYAPDPTGATC-TINWRNNDTS 185
Cdd:cd15384  84 LYLSTYITVLISLDRCVAILYPMKRNQAPERVR-RMVTVAWILSPIFSIPQAVIFhvERGPFVEDFHQCvTYGFYTAEWQ 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  186 FVSYTMMVIVVNFIVPLTVMFYCY----YHVSRSLRLYAASDcTAHLHRDWADQADVTK-------MSVIMILMFLLAWS 254
Cdd:cd15384 163 EQLYNMLSLVFMFPIPLVIMVTCYvlifITLSKSSRDFQGLE-IYTRNRGPNRQRLFHKakvkslrMSAVIVTAFILCWT 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 3024316  255 PYSIVCLWACFGNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAH 298
Cdd:cd15384 242 PYYVIMIWFLFFNPYPLNDILFDVIFFFGMSNSCVNPLIYGAFH 285
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
39-302 4.39e-15

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 73.94  E-value: 4.39e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   39 SILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIgVSSIGYPMSAASDLHGsWKFGHAGCQIYAGLNIFFGMVSIGLLTV 118
Cdd:cd15182  14 SLLGNGLVLWILVKYEKLKTLTNIFILNLAISDL-LFTFTLPFWASYHSSG-WIFGEILCKAVTSIFYIGFYSSILFLTL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  119 VAMDRYLTISCPDVGRRMTTNTYLSMI-LGAWINGLFWALMPIIGWASYAPDPTGATC---TINWRnndtsFVSYTMMVI 194
Cdd:cd15182  92 MTIDRYLAVVHPLSALRSRKLRYASLVsVAVWVISILASLPELILSTVMKSDEDGSLCeysSIKWK-----LGYYYQQNL 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  195 VvnFIVPLTVMFYCYYHVSRSLrLYAAsdcTAHLHRdwadqadVTKMSVIMILMFLLAWSPYSIVCLWACFGNPKKIP-- 272
Cdd:cd15182 167 F--FLIPLGIIVYCYVRILQTL-MRTR---TMRKHR-------TVKLIFVIVLVFFLSWAPYNIVIFLRSLKDLTIPIce 233
                       250       260       270
                ....*....|....*....|....*....|....*
gi 3024316  273 -----PSMAIIAPLFAKSSTFYNPCIYVAAHKKFR 302
Cdd:cd15182 234 cskqlDYAFYICRNIAFSHCCLNPVFYVFVGVKFR 268
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
26-303 4.81e-15

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 74.04  E-value: 4.81e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   26 SVIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLN 105
Cdd:cd15209   1 SALACVLIVTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYPYPLILHAIFHNGWTLGQLHCQASGFIM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  106 IFFGMVSIGLLTVVAMDRYLTIsCPDVG-----RRMTTNTYLSMIlgaWINGLFwALMPIIGWASYAPDPTGATCTINWR 180
Cdd:cd15209  81 GLSVIGSIFNITAIAINRYCYI-CHSLQydrlySLRNTCCYLCLT---WLLTVL-AVLPNFFIGSLQYDPRIYSCTFAQT 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  181 NNDtsfvSYTMMVIVVNFIVPLTVMFYCYYHV---SRSLRLYAASDCTAHLHRdwADQADVTKMSVIMILmFLLAWSPYS 257
Cdd:cd15209 156 VST----VYTITVVVIHFLLPLLIVSFCYLRIwvlVLQVRQRVKPDQRPKLKP--ADVRNFLTMFVVFVL-FAVCWAPLN 228
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 3024316  258 IVCLwACFGNPKK----IPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRK 303
Cdd:cd15209 229 FIGL-AVAINPKEmapkIPEWLFVASYFMAYFNSCLNAIIYGLLNQNFRK 277
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
39-304 5.04e-15

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 73.83  E-value: 5.04e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   39 SILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFGMVSIGLLTV 118
Cdd:cd15322  14 TVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCA 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  119 VAMDRYLTIS-CPDVGRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTGATCTIN---WrnndtsfvsYTMMVI 194
Cdd:cd15322  94 ISLDRYWSITqAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKKSGQPEGPICKINdekW---------YIISSC 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  195 VVNFIVPLTVMFYCYyhvsrsLRLYAASDctahlhrdwADQADVTKMSVIMILMFLLAWSP----YSIVCLWACFgnpkk 270
Cdd:cd15322 165 IGSFFAPCLIMVLVY------IRIYQIAK---------NREKRFTFVLAVVIGVFVICWFPffftYTLTAVCDCS----- 224
                       250       260       270
                ....*....|....*....|....*....|....
gi 3024316  271 IPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15322 225 VPETLFKFFFWFGYCNSSLNPVIYTIFNHDFRRA 258
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
39-303 5.16e-15

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 74.33  E-value: 5.16e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   39 SILSNVVVLG-IFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFfGMVSIGLLT 117
Cdd:cd15383  14 SACSNLAVLWsATRNRRRKLSHVRILILHLAAADLLVTFVVMPLDAAWNVTVQWYAGDLACRLLMFLKLF-AMYSSAFVT 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  118 VV-AMDRYLTISCP----DVGRRMTTntylsMILGAWINGLFWALMPIIGW--ASYAPDPTGATCTINwrnndTSFVS-- 188
Cdd:cd15383  93 VViSLDRHAAILNPlaigSARRRNRI-----MLCAAWGLSALLALPQLFLFhtVTATPPVNFTQCATH-----GSFPAhw 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  189 ----YTMMVIVVNFIVPLTVMFYCYYH----VSRSLR---LYAASDCTAHLHRDWADQADVT--KMSVIMILMFLLAWSP 255
Cdd:cd15383 163 qetlYNMFTFFCLFLLPLLIMIFCYTRilleISRRMKekkDSAKNEVALRSSSDNIPKARMRtlKMTIVIVSSFIVCWTP 242
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 3024316  256 YSIVCLWACFgNPK----KIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRK 303
Cdd:cd15383 243 YYLLGLWYWF-SPEmleqTVPESLSHILFLFGLLNACLDPLIYGLFTISFRR 293
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
27-302 6.83e-15

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 73.93  E-value: 6.83e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAgITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGS-WKFGHAGCQIYAGLN 105
Cdd:cd15392   3 IILMYSTIF-VLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPFSFIALLILQyWPFGEFMCPVVNYLQ 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  106 IFFGMVSIGLLTVVAMDRYLTISCPdVGRRMTTNTYLSMILGAWINGLFWALmPIIGWASYAPDPTGAT----CTINWRN 181
Cdd:cd15392  82 AVSVFVSAFTLVAISIDRYVAIMWP-LRPRMTKRQALLLIAVIWIFALATAL-PIAITSRLFEDSNASCgqyiCTESWPS 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  182 NDTSFVsYTMMVIVVNFIVPLTVMFYCYYHVSRslRLYAAS-DCTAHLHRDWADQADVTK---MSVIMILMFLLAWSPYS 257
Cdd:cd15392 160 DTNRYI-YSLVLMILQYFVPLAVLVFTYTRIGI--VVWAKRtPGEAENNRDQRMAESKRKlvkMMITVVAIFALCWLPLN 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 3024316  258 IVCLWACFGNPKKIPPSMAII---APLFAKSSTFYNPCIYVAAHKKFR 302
Cdd:cd15392 237 ILNLVGDHDESIYSWPYIPYLwlaAHWLAMSHCCYNPFIYCWMNAKFR 284
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
34-304 1.04e-14

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 73.10  E-value: 1.04e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   34 VAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFGMVSI 113
Cdd:cd15096   9 LIFIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFCVPFTATDYVLPTWPFGDVWCKIVQYLVYVTAYASV 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  114 GLLTVVAMDRYLTISCPDVGRRMTT--NTYLsMILGAWINgLFWALMPII---GWASYA-PDPTGATCTINWrNNDTSFV 187
Cdd:cd15096  89 YTLVLMSLDRYLAVVHPITSMSIRTerNTLI-AIVGIWIV-ILVANIPVLflhGVVSYGfSSEAYSYCTFLT-EVGTAAQ 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  188 SYTMMVIVVNFIVPLTVMFYCYYHVSRSLRlYAASDCTAHLHRDWADQADVTKMSVIMILMFLLAWSPYSIVCLWACFGN 267
Cdd:cd15096 166 TFFTSFFLFSYLIPLTLICVLYMLMLRRLR-RQKSPGGRRSAESQRGKRRVTRLVVVVVVVFAICWLPIHIILLLKYYGV 244
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 3024316  268 PKKIPP--SMAIIAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15096 245 LPETVLyvVIQILSNCLAYGNSCVNPILYAFLSQNFRKA 283
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
27-304 1.28e-14

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 73.09  E-value: 1.28e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSilsNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQiyagLNI 106
Cdd:cd15095   5 LIFAIIFLVGLAG---NSLVIYVVSRHREMRTVTNYYIVNLAVTDLAFLVCCVPFTAALYATPSWVFGDFMCK----FVN 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGMVSI----GLLTVVAMDRYLTISCP--DVGRRmTTNTYLSMILGAWInGLFWALMPII---GWASYAPDPTGATCTI 177
Cdd:cd15095  78 YMMQVTVqatcLTLTALSVDRYYAIVHPirSLRFR-TPRVAVVVSACIWI-VSFLLSIPVAiyyRLEEGYWYGPQTYCRE 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  178 NWRnNDTSFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSL--RLYAASDCTAHLHRDWADQ-ADVTKMSVIMILMFLLAWS 254
Cdd:cd15095 156 VWP-SKAFQKAYMIYTVLLTYVIPLAIIAVCYGLILRRLwrRSVDGNNQSEQLSERALRQkRKVTRMVIVVVVLFAICWL 234
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 3024316  255 PYSIVCLWACFG-NPKKIPPSMA--IIAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15095 235 PNHVLNLWQRFDpNFPETYATYAlkIAALCLSYANSAVNPFVYAFMGENFRKY 287
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
27-303 1.43e-14

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 72.55  E-value: 1.43e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLivaGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNI 106
Cdd:cd15301   5 IVAAVL---SLVTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVISMPLFTVYTALGYWPLGYEVCDTWLAIDY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGMVSIGLLTVVAMDRYLTISCPDVGR-RMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPT--GATCTINWRNND 183
Cdd:cd15301  82 LASNASVLNLLIISFDRYFSVTRPLTYRaRRTTKKAAVMIASAWIISLLLWPPWIYSWPYIEGKRTvpAGTCYIQFLETN 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  184 TSFvsyTMMVIVVNFIVPLTVMFYCYYHVSRSLRlyaasdctahlHRDWADQADVTKMSVIMILMFLLAWSPYSIVCLW- 262
Cdd:cd15301 162 PYV---TFGTALAAFYVPVTIMCILYWRIWRETK-----------KRQKKQESKAAKTLSAILLAFIVTWTPYNVLVLIk 227
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 3024316  263 ACFGNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRK 303
Cdd:cd15301 228 AFFPCSDTIPTELWDFSYYLCYINSTINPLCYALCNAAFRR 268
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
34-303 1.45e-14

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 72.63  E-value: 1.45e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   34 VAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIgVSSIGYPMSAASDLHGS---------WKFGhAGCQIYAGL 104
Cdd:cd15136   9 FVFLLALVGNIIVLLVLLTSRTKLTVPRFLMCNLAFADF-CMGIYLGLLAIVDAKTLgeyynyaidWQTG-AGCKTAGFL 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  105 NIFFGMVSIGLLTVVAMDRYLTISCP-DVGRRMTTNTYLSMILGAWINGLFWALMPIIGWASYApdpTGATCtINWRNND 183
Cdd:cd15136  87 AVFSSELSVFTLTVITLERWYAITHAmHLNKRLSLRQAAIIMLGGWIFALIMALLPLVGVSSYS---KTSIC-LPFETET 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  184 TSFVSYTMMVIVVNFIVPLTVMFyCYYHVSRSLRlyaASDCTAHlHRDWAdqadVTKMSVIMILMFLLAWSPYSIVCLWA 263
Cdd:cd15136 163 PVSKAYVIFLLLFNGLAFLIICG-CYIKIYLSVR---GSGRAAN-SNDTR----IAKRMALLVFTDFLCWAPIAFFGLTA 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 3024316  264 CFGNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRK 303
Cdd:cd15136 234 AFGLPLISVSNAKILLVFFYPLNSCANPFLYAIFTKQFRR 273
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
27-303 1.72e-14

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 72.68  E-value: 1.72e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIgYPMSAASDLHGSWKFGHAGCQIYAGLNI 106
Cdd:cd15089   2 AITALYSVVCVVGLLGNVLVMYGIVRYTKMKTATNIYIFNLALADALATST-LPFQSAKYLMETWPFGELLCKAVLSIDY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMilgawINGLFWALMPIIGW------ASYAPDPTGATCTINWR 180
Cdd:cd15089  81 YNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKL-----INICIWVLSSGVGVpimvmaVTKTPRDGAVVCMLQFP 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  181 NNDTSFVSYTMM-VIVVNFIVPLTVMFYCYYHVS---RSLRLYAAS-DCTAHLHRdwadqadVTKMSVIMILMFLLAWSP 255
Cdd:cd15089 156 SPSWYWDTVTKIcVFIFAFVVPILVITVCYGLMIlrlRSVRLLSGSkEKDRNLRR-------ITRMVLVVVAAFIICWTP 228
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 3024316  256 YSI-VCLWACFGNPKKIPPSMA----IIAPLFAKSStfYNPCIYVAAHKKFRK 303
Cdd:cd15089 229 IHIfVIVWTLVDIDRRNPLVVAalhlCIALGYANSS--LNPVLYAFLDENFKR 279
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
26-303 1.93e-14

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 72.24  E-value: 1.93e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   26 SVIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLN 105
Cdd:cd15402   1 TALACILIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLTSIFHNGWNLGYLHCQISGFLM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  106 IFFGMVSIGLLTVVAMDRYLTIsCPDV--GRRMTTNTYLSMILGAWINGLFwALMPIIGWASYAPDPTGATCTInwrnND 183
Cdd:cd15402  81 GLSVIGSIFNITGIAINRYCYI-CHSLkyDKLYSDKNSLCYVLLIWVLTVA-AIVPNLFVGSLQYDPRIYSCTF----AQ 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  184 TSFVSYTMMVIVVNFIVPLTVMFYCYY-------HVSRSLRLYAASDCTAHLHRDWadqadvTKMSVIMILmFLLAWSPY 256
Cdd:cd15402 155 SVSSAYTIAVVFFHFILPIIIVTFCYLriwilviQVRRRVKPDNKPKLKPHDFRNF------VTMFVVFVL-FAVCWAPL 227
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 3024316  257 SIVCLwACFGNPKKIPPSmaIIAPLFAKS--STFYNPC----IYVAAHKKFRK 303
Cdd:cd15402 228 NFIGL-AVAVDPETIVPR--IPEWLFVASyyMAYFNSClnaiIYGLLNQNFRR 277
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
37-303 2.35e-14

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 72.43  E-value: 2.35e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   37 ITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFGMVSIGLL 116
Cdd:cd15195  12 VISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVTFFNMPMDAVWNYTVEWLAGDLMCRVMMFLKQFGMYLSSFML 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  117 TVVAMDRYLTISCPdVGRRMTTNTYLSMILGAWINGLFWALMP--IIGWASYAPDPTGATCTINWRNNDTSFVS--YTMM 192
Cdd:cd15195  92 VVIALDRVFAILSP-LSANQARKRVKIMLTVAWVLSALCSIPQsfIFSVLRKMPEQPGFHQCVDFGSAPTKKQErlYYFF 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  193 VIVVNFIVPLTVMFYCY----YHVSRSLRLYAASDCTAHLHRDWAD----QADVTKMSVIMILMFLLAWSPYSIVCLWAC 264
Cdd:cd15195 171 TMILSFVIPLIITVTCYllilFEISKMAKRARDTPISNRRRSRTNSleraRMRTLRMTALIVLTFIVCWGPYYVLGLWYW 250
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 3024316  265 FGNP--KKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRK 303
Cdd:cd15195 251 FDKEsiKNLPPALSHIMFLLGYLNPCLHPIIYGVFMKEIRN 291
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
27-215 2.48e-14

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 71.69  E-value: 2.48e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNI 106
Cdd:cd15060   2 VTTILLSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLPLNVAYFLLGKWLFGIHLCQMWLTCDI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGMVSIGLLTVVAMDRYLTISCP-DVGRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTGAT-CTInwrNNDT 184
Cdd:cd15060  82 LCCTASILNLCAIALDRYWAIHDPiNYAQKRTLKRVLLMIVVVWALSALISVPPLIGWNDWPENFTETTpCTL---TEEK 158
                       170       180       190
                ....*....|....*....|....*....|.
gi 3024316  185 SFVSYTMMvivVNFIVPLTVMFYCYYHVSRS 215
Cdd:cd15060 159 GYVIYSSS---GSFFIPLLIMTIVYVKIFIA 186
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
32-305 2.54e-14

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 72.07  E-value: 2.54e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   32 LIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFGMV 111
Cdd:cd15000   6 FLPVVLFGIFGNFVLLYILASNRSLRTPTNLLIGNMALADLLTLLVCPWMFLVHDFFQNYVLGSVGCKLEGFLEGSLLLA 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  112 SIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILgAWINGLFWALmPIIGWASYAPDptgatctiNWRNNDTSFV---- 187
Cdd:cd15000  86 SVLALCAVSYDRLTAIVLPSEARLTKRGAKIVIVI-TWIVGLLLAL-PLAIYRSYRER--------QWKNFLETYCaent 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  188 ----SYTMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAASDCTAHLHRDWADQADVTKMSVIMILMFLLAWSPYSIVCLWA 263
Cdd:cd15000 156 qvlpIYWHVIITVLVWLPLGIMLICYSAIFWKLDKYERRVLRREHPSVVRYKKKAAKTLFIVLITFVVCRIPFTALIFYR 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 3024316  264 cFGNPKKIPPSMAIIAPL----FAKSSTFY-----NPCIYVAAHKKFRKAM 305
Cdd:cd15000 236 -YKLVPNDNTQNSVSGSFhilwFASKYLMFlnaavNPLIYGFTNENFRKAF 285
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
30-302 2.86e-14

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 72.02  E-value: 2.86e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   30 AYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFG 109
Cdd:cd14986   5 AVLGVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFTVLTQIIWEATGEWVAGDVLCRIVKYLQVVGL 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  110 MVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLsMILGAWINGLFWAL-------------MPIIGWASYaPDPTGATCT 176
Cdd:cd14986  85 FASTYILVSMSLDRYQAIVKPMSSLKPRKRARL-MIVVAWVLSFLFSIpqlvifverelgdGVHQCWSSF-YTPWQRKVY 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  177 INWrnndtsfvsytMMVIVvnFIVPLTVMFYCYYHVSRSL----RLYAASDCTAHlhRDWADQAD--------------- 237
Cdd:cd14986 163 ITW-----------LATYV--FVIPLIILSYCYGRILRTIwirsRQKTDRPIAPT--AMSCRSVScvssrvslisrakik 227
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 3024316  238 VTKMSVIMILMFLLAWSPYSIVCLWACFGNPKKIPPSMAIIAPLFAKSSTFYNPCIY--VAAHKKFR 302
Cdd:cd14986 228 TIKMTLVIILAFILCWTPYFIVQLLDVYAGMQQLENDAYVVSETLASLNSALNPLIYgfFSSHLSFE 294
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
28-304 3.01e-14

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 72.04  E-value: 3.01e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   28 IAAYLIVAgITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIF 107
Cdd:cd15208   4 IALYILVF-IVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPATLLVDVTETWFFGQVLCKIIPYLQTV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  108 FGMVSIGLLTVVAMDRYLTIsCPDVGRRMTTNTYLSMILGAWINGLFWA--------LMPIIGWASYAPDPTgaTCTINW 179
Cdd:cd15208  83 SVSVSVLTLSCIALDRWYAI-CHPLMFKSTAKRARVSILIIWIVSLLIMipqaivmeCSRVVPLANKTILLT--VCDERW 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  180 rNNDTSFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAASDCTAHLHRDWADQADVT---------------KMSVI 244
Cdd:cd15208 160 -SDSIYQKVYHICFFLVTYLLPLCLMILAYFQIFRKLWCRQIPGTSSVVQRKWNKPRKSAvaaeekqlrsrrktaKMLIV 238
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 3024316  245 MILMFLLAWSPYSIVCL----WACFGNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15208 239 VVIMFAICYLPVHLLNIlryvFGLFTVDRETIYAWFLFSHWLVYANSAINPIIYNFMSGKFREE 302
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
27-305 4.83e-14

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 71.32  E-value: 4.83e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAgITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNI 106
Cdd:cd15012   2 FIILYTLVF-CCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSM-ILGAWINGLFWALMPIIGWASY-APDPTGATCTINW--RNN 182
Cdd:cd15012  81 LSYTASIGILVVISVERYIAILHPLRCKQLLTAARLRVtIVTVWLTSAVYNTPYFVFSQTVeILVTQDGQEEEICvlDRE 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  183 DTSFVSYTMMVIVVNFIVPLTVMFYCYYHVSrslrlYAASDCTAHLHRdwadqADVTKMSVIMILMFLLAWSPYSIVCLW 262
Cdd:cd15012 161 MFNSKLYDTINFIVWYLIPLLIMTVLYSKIS-----IVLWKSSSIEAR-----RKVVRLLVAVVVSFALCNLPYHARKMW 230
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 3024316  263 ACFGNPKKIPPSM-AIIAP---LFAKSSTFYNPCIYVAAHKKFRKAM 305
Cdd:cd15012 231 QYWSEPYRCDSNWnALLTPltfLVLYFNSAVNPLLYAFLSKRFRQSM 277
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
27-304 6.44e-14

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 70.96  E-value: 6.44e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNI 106
Cdd:cd14971   2 IVPLFFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPLPGWVFGDFMCKFVHYFQQ 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGMVSIGLLTVVAMDRYLTISCPDVGR-RMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTGAT-CTINWRNNDt 184
Cdd:cd14971  82 VSMHASIFTLVAMSLDRFLAVVYPLRSLhIRTPRNALAASGCIWVVSLAVAAPVLALHRLRNYTPGNRTvCSEAWPSRA- 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  185 SFVSYTMMVIVVNFIVPLTVMFYCYYHVSRslRLYAASDCTAHLHRDWADQADVTKMSVIMILMFLLAWSPYSIVCLWAC 264
Cdd:cd14971 161 HRRAFALCTFLFGYLLPLLLICVCYAAMLR--HLWRVAVRPVLSEGSRRAKRKVTRLVLVVVVLFAACWGPIHAILLLVA 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 3024316  265 FGNPKKIPPSMA--IIAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd14971 239 LGPFPLTYATYAlrIWAHCLAYSNSAVNPVLYAFLSEHFRKA 280
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
33-303 6.62e-14

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 70.77  E-value: 6.62e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   33 IVAGITSILS---NVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFG 109
Cdd:cd17790   5 ITTGILSLVTvtgNLLVLISFKVNSELKTVNNYFLLSLACADLIIGAFSMNLYTTYILMGHWALGTVACDLWLALDYVAS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  110 MVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILG-AW-INGLFWAlMPIIGWASYAPDPT--GATCTINWRNNDTs 185
Cdd:cd17790  85 NASVMNLLIISFDRYFSITRPLTYRAKRTPRRAAIMIGlAWlISFVLWA-PAILFWQYLVGERTvlAGQCYIQFLSQPI- 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  186 fvsYTMMVIVVNFIVPLTVMFYCYYHVsrslrlyaasdctahlHRDWADQADVTKMSVIMILMFLLAWSPYSIVCLWACF 265
Cdd:cd17790 163 ---ITFGTAIAAFYLPVTIMIILYWRI----------------YRETIKEKKAARTLSAILLAFILTWTPYNIMVLVSTF 223
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 3024316  266 GnPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRK 303
Cdd:cd17790 224 C-KDCVPKTLWELGYWLCYVNSTVNPMCYALCNKSFRD 260
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
39-305 1.03e-13

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 70.23  E-value: 1.03e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   39 SILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFGMVSIGLLTV 118
Cdd:cd15979  14 SVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIFGEVICKAVAYLMGVSVSVSTFSLVA 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  119 VAMDRYLTISCPDVGRRMTTNTYLSMILGA-WI-NGLFWALMPIIGWASYAPD---PTGATCTINWRNNDTSFVSYTMMV 193
Cdd:cd15979  94 IAIERYSAICNPLQSRVWQTRSHAYRVIAAtWLlSGLIMIPYPVYSVTVPVPVgdrPRGHQCRHAWPSAQVRQAWYVLLL 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  194 IVVnFIVPLTVMFYCYYHVSRslrlyaasdctaHLHRDWADQADVTKMSVIMILMFLLAWSPYSIVCLWACFGNP---KK 270
Cdd:cd15979 174 LIL-FFIPGVVMIVAYGLISR------------ELYRGLLAKKRVIRMLVVIVAMFFLCWLPIFSANTWRAFDPLsahRA 240
                       250       260       270
                ....*....|....*....|....*....|....*
gi 3024316  271 IPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKAM 305
Cdd:cd15979 241 LSGAPISFIHLLSYTSACVNPLVYCFMNRRFRKAF 275
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
27-265 1.06e-13

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 70.27  E-value: 1.06e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDiGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNI 106
Cdd:cd15973   2 VIQFIYALVCLVGLIGNSMVIFVILRYAKMKTATNIYILNLAIAD-ELFMLSVPFLAASAALQHWPFGSAMCRTVLSVDG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMI-LGAWINGLFWALmPIIGWASYAPDPTGA-TCTINWRNN-- 182
Cdd:cd15973  81 INMFTSVFCLTVLSVDRYIAVVHPLRAARYRRPTVAKMInICVWILSLLVIS-PIIIFADTATRKGQAvACNLIWPHPaw 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  183 DTSFVSYTMMvivVNFIVPLTVMFYCYYHVSRSLRLYAASdctAHLHRDWADQADVTKMSVIMILMFLLAWSPYSIVCLW 262
Cdd:cd15973 160 SAAFVIYTFL---LGFLLPVLAIGLCYILIIGKMRAVALK---AGWQQRRKSEKKITRMVLMVVTVFVICWMPFYVVQLL 233

                ...
gi 3024316  263 ACF 265
Cdd:cd15973 234 NLF 236
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
31-304 1.06e-13

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 70.00  E-value: 1.06e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   31 YLIVAGITSILS---NVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIF 107
Cdd:cd15001   2 VIIVYVITFVLGligNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCKAVAYLQLL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  108 FGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTY-LSMILGAWINGLFWAlMPIIGWASYAPDPTGATCTINWRNNDTSF 186
Cdd:cd15001  82 SFICSVLTLTAISIERYYVILHPMKAKSFCTIGRaRKVALLIWILSAILA-SPVLFGQGLVRYESENGVTVYHCQKAWPS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  187 VS----YTMMVIVVNFIVPLTVMFYCYyhvsrslrlyaasdctAHLHRDWadqadVTKMSVIMILMFLLAWSPYSIVCLW 262
Cdd:cd15001 161 TLysrlYVVYLAIVIFFIPLIVMTFAY----------------ARDTRKQ-----VIKMLISVVVLFAVCWGPLLIDNLL 219
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 3024316  263 ACFG----NPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15001 220 VSFDvistLHTQALKYMRIAFHLLSYANSCINPIIYAFMSKNFRSS 265
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
37-303 1.29e-13

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 70.17  E-value: 1.29e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   37 ITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIgVSSIGYPMSAASDLHgSWKFGHAGCQIYAGL---NIFFGMVSI 113
Cdd:cd15184  12 IFGFVGNMLVVLILINCKKLKSMTDIYLLNLAISDL-LFLLTLPFWAHYAAN-EWVFGNAMCKLLTGLyhiGFFSGIFFI 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  114 GLLTvvaMDRYLTISCPDVGRRMTTNTYLSMILG-AWINGLFwALMPIIGWASYAPDPTGATCTINWRNNDTSFVS--YT 190
Cdd:cd15184  90 ILLT---IDRYLAIVHAVFALKARTVTFGVVTSVvTWVVAVF-ASLPGIIFTKSQKEGSHYTCSPHFPPSQYQFWKnfQT 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  191 MMVIVVNFIVPLTVMFYCYYHVSRSLRlyaasdctaHLHRDWADQADVTKMSVIMILMFLLaWSPYSIVCLWACF----- 265
Cdd:cd15184 166 LKMNILGLVLPLLVMIICYSGILKTLL---------RCRNEKKRHKAVRLIFTIMIVYFLF-WAPYNIVLLLNTFqeffg 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 3024316  266 ----GNPKKIPPSMAIIAPLfAKSSTFYNPCIYVAAHKKFRK 303
Cdd:cd15184 236 lnncSSSNRLDQAMQVTETL-GMTHCCINPVIYAFVGEKFRS 276
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
32-212 1.60e-13

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 70.17  E-value: 1.60e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   32 LIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFGMV 111
Cdd:cd15058   7 LALIILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCELWTSVDVLCVTA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  112 SIGLLTVVAMDRYLTISCP-DVGRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTGATCTINWRNNDtsFVS-- 188
Cdd:cd15058  87 SIETLCVIAVDRYIAITRPlRYQVLLTKRRARVIVCVVWIVSALVSFVPIMNQWWRANDPEANDCYQDPTCCD--FRTnm 164
                       170       180
                ....*....|....*....|....*
gi 3024316  189 -YTMMVIVVNFIVPLTVMFYCYYHV 212
Cdd:cd15058 165 aYAIASSVVSFYIPLLIMIFVYARV 189
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
27-304 1.85e-13

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 69.99  E-value: 1.85e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSILSNVVVLGIFIKYKELRTP-TNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGhAGCQIYAGLN 105
Cdd:cd15319   2 VTGCLLSLLILWTLLGNILVCAAVVRFRHLRSKvTNIFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFG-AFCDVWVAFD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  106 IFFGMVSIGLLTVVAMDRYLTISCP-DVGRRMTTNTYLSMILGAWINGLFWALMPI-IGW-----ASYAPDPTGATCTIN 178
Cdd:cd15319  81 IMCSTASILNLCVISVDRYWAISSPfRYERKMTQRVALVMISVAWTLSVLISFIPVqLNWhkdsgDDWVGLHNSSISRQV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  179 WRNNDTSF-VSYTMMVIVVNFIVPLTVMFYCYYHVSR----------SLRLYA---------ASDCTAH--LHRDWADQA 236
Cdd:cd15319 161 EENCDSSLnRTYAISSSLISFYIPVAIMIVTYTRIYRiaqiqirrisSLERAAehaqscrsnRIDCHHHtsLRTSIKKET 240
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 3024316  237 DVTKMSVIMILMFLLAWSPYSIV-CLWA-CFGNPKKIPPSMAIIAPL-------FAKSSTFYNPCIYvAAHKKFRKA 304
Cdd:cd15319 241 KVLKTLSVIMGVFVCCWLPFFILnCMVPfCDRPPADPDAGLPCVSETtfdvfvwFGWANSSLNPIIY-AFNADFRKV 316
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
28-304 3.13e-13

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 69.31  E-value: 3.13e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   28 IAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHG-SWKFGHAGCQIYAGLNI 106
Cdd:cd14979   3 VTAIYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWWQyPWAFGDGGCKLYYFLFE 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILGA-WINGLFWAlMPIIGW--------ASYAPDPTGATCTI 177
Cdd:cd14979  83 ACTYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAiWLVSILCA-IPILFLmgiqylngPLPGPVPDSAVCTL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  178 nwrNNDTSFVSYTMMV-IVVNFIVPLTVMFYCYYHVS---RSLRLYAASDCTAHLHRDWADQADVTKMSVIMIL-----M 248
Cdd:cd14979 162 ---VVDRSTFKYVFQVsTFIFFVLPMFVISILYFRIGvklRSMRNIKKGTRAQGTRNVELSLSQQARRQVVKMLgavviA 238
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 3024316  249 FLLAWSPYSIVCLWACF-----GNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd14979 239 FFVCWLPFHAQRLMFSYaskedTFLFDFYQYLYPISGILFYLSSAINPILYNLMSSRFRVA 299
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
27-305 3.49e-13

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 69.07  E-value: 3.49e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGItSILSNVVVLGIFIKYKELRT--PTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQI---Y 101
Cdd:cd14976   3 VSVVYMVVFTV-GLLGNLLVLYLLKSNKKLRQqsESNKFVFNLALTDLIFVLTLPFWAVEYALDFVWPFGTAMCKVvryV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  102 AGLNIFfgmVSIGLLTVVAMDRYLTISCPdVGRRMTTNTYLSMILGAWINGLfwALMPIIGWASYAPDPTGAT----CTI 177
Cdd:cd14976  82 TKLNMY---SSIFFLTALSVTRYIAVARA-LKHGWIRKAFGAFATTIAIWAA--AALAAIPEAIFSTDTWSSVnhtlCLL 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  178 NWRNNDTSFVSYTMMVI------VVNFIVPLTVMFYCYYHVSRSLRlyaasdctAHLHRDWADQADVTKMSVIMILMFLL 251
Cdd:cd14976 156 RFPKNSSVTRWYNWLGMyqlqkvVLGFFLPLGIITLSYLLLLRFLQ--------RKRGGSKRRKSRVTKSVFIVVLSFFI 227
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 3024316  252 AWSPYSIVCLWACFGNPKKIPPSMAI---------IAPLFAKSSTFYNPCIYVAAHKKFRKAM 305
Cdd:cd14976 228 CWLPNQALSLWSALIKFDDVPFSDAFfafqtyafpVAICLAHSNSCLNPVLYCLVRREFRDAL 290
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
26-310 3.62e-13

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 68.81  E-value: 3.62e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   26 SVIAAYLIVAGITSILSNVVVLgiFIKYKELR-TPTNAVIINLAFTDIGVSSIGYPMS-AASDLHGSWKFGHAGCQIYAG 103
Cdd:cd14981   4 PAPPALMFVFGVLGNLLALIVL--ARSSKSHKwSVFYRLVAGLAITDLLGILLTSPVVlAVYASNFEWDGGQPLCDYFGF 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  104 LNIFFGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILGA-WINGLFWALMPIIGWASYAPDPTGATCTINWRNN 182
Cdd:cd14981  82 MMSFFGLSSLLIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAvWAFALLIASLPLLGLGSYVLQYPGTWCFLDFYSK 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  183 DTSFVSYTMM-------VIVVNFIVPLTVMFYCYYHVSRSLRLYAASdcTAHLHRDWADQADVTKMSVIMILmFLLAWSP 255
Cdd:cd14981 162 NTGDAAYAYLysilgllILLVTLLCNLLVIITLLRMRRRKKRHRRSR--RSARRQKRNEIQMVVLLLAITVV-FSVCWLP 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 3024316  256 YSIVCLWACFGNPKKIPPsMAIIAPLFAKSSTFYNPCIYVAahkkFRKAMLAMFK 310
Cdd:cd14981 239 LMIRVLINATGDSEKNGK-TDLLAVRMASWNQILDPWVYIL----LRKEVLRRLY 288
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
31-259 4.18e-13

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 68.67  E-value: 4.18e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   31 YLIVAGItSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIgVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFGM 110
Cdd:cd15974   7 YLLVCAI-GLSGNTLVIYVVLRYAKMKTVTNIYILNLAVADE-LFMLGLPFLATQNAISYWPFGSFLCRLVMTVDGVNQF 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  111 VSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDptGATCTINWRNN----DTSF 186
Cdd:cd15974  85 TSIFCLTVMSIDRYLAVVHPIKSTKWRRPRVAKLINATVWTLSFLVVLPVIIFSDVQPD--LNTCNISWPEPvsvwSTAF 162
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 3024316  187 VSYTMmviVVNFIVPLTVMFYCYYHVSRSLRlyaASDCTAHLHRDWADQADVTKMSVIMILMFLLAWSPYSIV 259
Cdd:cd15974 163 IIYTA---VLGFFGPLLVICLCYLLIVIKVK---SSGLRVGSTKRRKSERKVTRMVVIIVVVFVFCWLPFYML 229
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
33-304 4.75e-13

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 68.22  E-value: 4.75e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   33 IVAGITSILsNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFGMVS 112
Cdd:cd15050   9 TISLITVIL-NLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSMDYVASTAS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  113 IGLLTVVAMDRYLTISCP-DVGRRMTTNTYLSMILGAWINGLFWaLMPIIGWASYApdpTGATCTINWRNNDTSFVSYT- 190
Cdd:cd15050  88 IFSLFILCIDRYRSVQQPlKYLKYRTKTRASLMISGAWLLSFLW-VIPILGWHHFA---RGGERVVLEDKCETDFHDVTw 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  191 --MMVIVVNFIVPLTVM--FYC--YYHVSRslrlyaasdctahlHRDWADQadvtkMSVIMIlMFLLAWSPYSIVCLWAC 264
Cdd:cd15050 164 fkVLTAILNFYIPSLLMlwFYAkiFKAVNR--------------ERKAAKQ-----LGFIMA-AFILCWIPYFILFMVIA 223
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 3024316  265 FgNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15050 224 F-CKNCCNENLHMFTIWLGYINSTLNPFIYPLCNENFKKT 262
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
28-312 5.06e-13

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 68.44  E-value: 5.06e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   28 IAAYLIVAGitSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIF 107
Cdd:cd15307   5 LLALVLVLG--TAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWICLDVL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  108 FGMVSIGLLTVVAMDRYLTISCP-DVGRRMTTNTYLSMILGAWINGLFWALmPIIgwASYAPDP----TGATCTInwrnn 182
Cdd:cd15307  83 FCTASIMHLCTISVDRYLSLRYPmRFGRNKTRRRVTLKIVFVWLLSIAMSL-PLS--LMYSKDHasvlVNGTCQI----- 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  183 dtSFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLrlyaaSDCTAHLHRDWADQADVTKMSVIMILMFLLAWSPYSI--VC 260
Cdd:cd15307 155 --PDPVYKLVGSIVCFYIPLGVMLLTYCLTVRLL-----ARQRSRHGRIIRLEQKATKVLGVVFFTFVILWSPFFVlnLL 227
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 3024316  261 LWACFGNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKAMLAMFKCQ 312
Cdd:cd15307 228 PTVCAECEERISHWVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVLLCR 279
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
31-303 7.37e-13

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 67.87  E-value: 7.37e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   31 YLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIgVSSIGYPMSAASDLHG-SWKFGHAGCQIYAGLNIFFG 109
Cdd:cd15381   6 YLWIIFVLGTIENAFVLIVFCLHKSSCTVAEIYLGNLAAADL-LLVCCLPFWAINISNGfNWPFGEFLCKSVNAVIYMNL 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  110 MVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMI-LGAWINGLFWAlMPIIGW--ASYAPDPTGATCTINWRNNDTSF 186
Cdd:cd15381  85 YSSIYFLMMVSIDRYLALVKTMSSGRMRRPACAKLNcLIIWMFGLLMS-TPMIVFrtVMYFPEYNITACVLDYPSEGWHV 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  187 VSyTMMVIVVNFIVPLTVMFYCYYHVSRSLRlyaasDCTAHLHRDWADQADVTKMSVIMILMFLLAWSPYSIVCLWACFG 266
Cdd:cd15381 164 AL-NILLNVVGFLIPLSIITFCSTQIIQVLR-----NNKMQKFKEIQTERKATVLVLAVLLMFFICWLPFHIFTFLDTLH 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 3024316  267 NPKKIPPS--------MAIIAPLFAKSSTFYNPCIYVAAHKKFRK 303
Cdd:cd15381 238 KLGLISGCrwedildiGTQIATFLAYSNSCLNPLLYVIVGKHFRK 282
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
27-218 8.40e-13

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 68.01  E-value: 8.40e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNI 106
Cdd:cd15959   2 LAGALLSLAILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTSVDV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGMVSIGLLTVVAMDRYLTISCP-DVGRRMTTNTYLSMILGAWINGLFWALMPIIG-WASYAPDPTGATCTINWRNND- 183
Cdd:cd15959  82 LCVTASIETLCAIAVDRYLAITNPlRYEALVTKRRARTAVCLVWAISAAISFLPIMNqWWRDGADEEAQRCYDNPRCCDf 161
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 3024316  184 TSFVSYTMMVIVVNFIVPLTVMFYCYYHV----SRSLRL 218
Cdd:cd15959 162 VTNMPYAIVSSTVSFYVPLLVMIFVYVRVfvvaTRQVRL 200
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
26-309 8.60e-13

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 67.54  E-value: 8.60e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   26 SVIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLN 105
Cdd:cd15295   1 VVLLFLMSLLALVIVLGNALVIIAFVVDKNLRHRSNYFFLNLAISDFFVGAISIPLYIPYTLTNRWDFGRGLCVFWLVID 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  106 IFFGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTY--LSMILGAWINGLFWALMPIIGWASYAPDptGATCTINWRNND 183
Cdd:cd15295  81 YLLCTASVYNIVLISYDRYQSVSNAVSYRNQQTATLriVTQMVAVWVLAFLVHGPAILVSDSWKTE--DGECEPEFFSNW 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  184 tsfvSYTMMVIVVNFIVPLTVMFYCYYHVSRSlrlyaasdctahLHRDWADQaDVTKMSVIMILMFLLAWSPYSI--VCL 261
Cdd:cd15295 159 ----YILAITSVLEFLVPVILVAYFNTQIYWS------------LWKRLRDR-KLAKSLAIILGTFAICWAPYSLftIIR 221
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 3024316  262 WACFGNPKKIPPSMAIIAPLFaksSTFYNPCIYVAAHKKFRKAMLAMF 309
Cdd:cd15295 222 AACEKHRGSPWYNFAFWLQWF---NSFINPFLYPLCHKRFRKAFLKIF 266
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
28-303 9.77e-13

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 67.36  E-value: 9.77e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   28 IAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIF 107
Cdd:cd15300   3 IAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTSYILMGYWALGSLACDLWLALDYV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  108 FGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILG-AW-INGLFWAlMPIIGWASYAPDPT--GATCTINWRNND 183
Cdd:cd15300  83 ASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGlAWlISFILWA-PPILCWQYFVGKRTvpERECQIQFLSEP 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  184 TsfvsYTMMVIVVNFIVPLTVMFYCYyhvsrslrlyaasdctAHLHRDWADQADVTKMSVIMILMFLLAWSPYSIVCLWA 263
Cdd:cd15300 162 T----ITFGTAIAAFYIPVSVMTILY----------------CRIYKETIKERKAAQTLSAILLAFIITWTPYNIMVLVS 221
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 3024316  264 CFGNpKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRK 303
Cdd:cd15300 222 TFCS-DCIPLTLWHLGYWLCYVNSTVNPMCYALCNKTFRK 260
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
27-304 1.08e-12

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 66.87  E-value: 1.08e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNI 106
Cdd:cd15335   2 LIVLTLALITILTTVLNSAVIAAICTTKKLHQPANYLICSLAVTDFLVAVLVMPLSITYIVMDTWTLGYFICEIWLSVDM 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGMVSIGLLTVVAMDRYLTIS-CPDVGRRMTTNTYLSMILGAWINGLFWAlMPIIGWASYAPDPTGATCTInwrnnDTS 185
Cdd:cd15335  82 TCCTCSILHLCVIALDRYWAITdAIEYARKRTAKRAGLMILTVWTISIFIS-IPPLFWRNHHDANIPSQCII-----QHD 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  186 FVSYTMMVIVVNFIVPLTVMFYCYYhvsrslRLYAASdctahlhrdwADQADVTKMSVIMILMFLLAWSPYSIVCLWACF 265
Cdd:cd15335 156 HVIYTIYSTFGAFYIPLTLILILYY------RIYHAA----------SRERKAARILGLILGAFILSWLPFFIKELIVGL 219
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 3024316  266 gNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15335 220 -SVMTVSPEVADFLTWLGYVNSLVNPLLYTSFNEDFKLA 257
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
33-305 1.15e-12

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 67.32  E-value: 1.15e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   33 IVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIgVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFGMVS 112
Cdd:cd14972   6 IVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADL-LAGIAFVFTFLSVLLVSLTPSPATWLLRKGSLVLSLLAS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  113 IGLLTVVAMDRYLTISCPDV-GRRMTTNTYLSMILGAWINGLFWALMPIIGWASyaPDPTGATCTINWRNNDTSFVsytm 191
Cdd:cd14972  85 AYSLLAIAVDRYISIVHGLTyVNNVTNKRVKVLIALVWVWSVLLALLPVLGWNC--VLCDQESCSPLGPGLPKSYL---- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  192 MVIVVNFIVPLTVMFYCYYHVSRSLRLYAASDCTAHLHRDWADQADVTKMSVIMIL---MFLLAWSPYSIVCLWACFGNP 268
Cdd:cd14972 159 VLILVFFFIALVIIVFLYVRIFWCLWRHANAIAARQEAAVPAQPSTSRKLAKTVVIvlgVFLVCWLPLLILLVLDVLCPS 238
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 3024316  269 KKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKAM 305
Cdd:cd14972 239 VCDIQAVFYYFLVLALLNSAINPIIYAFRLKEMRRAV 275
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
37-305 1.19e-12

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 67.29  E-value: 1.19e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   37 ITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIgVSSIGYPMSAASDL-HGSWKFGHAGCQIyAGLNIFFGM-VSIG 114
Cdd:cd14982  12 ILGLLGNILALWVFLRKMKKRSPTTIYMINLALADL-LFVLTLPFRIYYYLnGGWWPFGDFLCRL-TGLLFYINMyGSIL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  115 LLTVVAMDRYLTISCPDVGRRMTTNTYLSMI-LGAWINGLFWALMPIIGWASYAPDPTGATCTINWRNNDTSFVSYTMMV 193
Cdd:cd14982  90 FLTCISVDRYLAVVHPLKSRRLRRKRYAVGVcAGVWILVLVASVPLLLLRSTIAKENNSTTCFEFLSEWLASAAPIVLIA 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  194 IVVNFIVPLTVMFYCYYHVSRSLRLYAASdctahlHRDWADQADVTKMSVIMILMFLLAWSPYSIVCLWACFGNPKKIPP 273
Cdd:cd14982 170 LVVGFLIPLLIILVCYSLIIRALRRRSKQ------SQKSVRKRKALRMILIVLAVFLVCFLPYHVTRILYLLVRLSFIAD 243
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 3024316  274 SMAIIAPLFAKSSTF--------YNPCIYVAAHKKFRKAM 305
Cdd:cd14982 244 CSARNSLYKAYRITLclaslnscLDPLIYYFLSKTFRKRL 283
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
27-304 1.70e-12

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 66.40  E-value: 1.70e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNI 106
Cdd:cd15404   2 ILSAVMIFILLVSFLGNFVVCLMVYQKAAMRSAINILLASLAFADMMLAVLNMPFALVTIITTRWIFGDAFCRVSAMFFW 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGMVSIGLLTVVAMDRYLTIscpdVGRRMTTNTYLSMILGA--WINGLFWALMPIIGWASYAPDPTGATCTINWrNNDT 184
Cdd:cd15404  82 LFVMEGVAILLIISIDRFLII----VQKQDKLNPYRAKVLIAvsWAVSFCVAFPLAVGSPDLQIPSRAPQCVFGY-TTNP 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  185 SFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAASDCTAHLhrdwadqadvtkmsvIMILMFLLAWSPYSIVCLWAC 264
Cdd:cd15404 157 GYQAYVILIMLIFFFIPFMVMLYSFMGILNTVRSFKTRAFTTIL---------------ILFIVFTVCWAPFTTYSLVAT 221
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 3024316  265 FGN-----PKKIPPSMAIIAPLFAKSStfYNPCIYVAAHKKFRKA 304
Cdd:cd15404 222 FNShfyhkHNFFEISTWLLWLCYLKSA--LNPLIYYWRIKKFRDA 264
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
26-302 2.08e-12

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 66.43  E-value: 2.08e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   26 SVIAAYLIVAgITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSsIGYPMSAASDLHGSWKFGHAGCQIYAGLN 105
Cdd:cd15092   2 TIVVVYLIVC-VVGLVGNCLVMYVILRHTKMKTATNIYIFNLALADTLVL-LTLPFQGTDIFLGFWPFGNALCKTVIAID 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  106 IFFGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMilgawINGLFWALMPIIG-----WASYAPDPTGATCTINWR 180
Cdd:cd15092  80 YYNMFTSTFTLTAMSVDRYVAICHPIKALDVRTPHKAKV-----VNVCIWALASVVGvpvmvMGSAQVEDEEIECLVEIP 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  181 NNDTSFVS-YTMMVIVVNFIVPLTVMFYCYYHVSRSLR----LYAASDCTAHLHRdwadqadVTKMSVIMILMFLLAWSP 255
Cdd:cd15092 155 TPQDYWDPvFGICVFLFSFIIPVLIISVCYSLMIRRLRgvrlLSGSKEKDRNLRR-------ITRLVLVVVAVFVGCWTP 227
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 3024316  256 YSIVCLWACFGNPKKIPPSMAI----IAPLFAKSStfYNPCIYVAAHKKFR 302
Cdd:cd15092 228 IQIFVLAQGLGVQPSSETAVAIlrfcTALGYVNSS--LNPVLYAFLDENFK 276
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
40-304 2.18e-12

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 66.29  E-value: 2.18e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   40 ILSNVVVLGIFIKYKEL--RTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFGMVSIGLLT 117
Cdd:cd15098  15 VLGNSLVITVLARVKPGkrRSTTNVFILNLSIADLFFLLFCVPFQATIYSLPEWVFGAFMCKFVHYFFTVSMLVSIFTLV 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  118 VVAMDRYLTISCPDVGR--RMTTNTYLSMILgAWINGLFWAlMPIIGWASYAPDPTGATCTINWRN--NDTSFVSYTMMV 193
Cdd:cd15098  95 AMSVDRYIAVVHSRTSSslRTRRNALLGVLV-IWVLSLAMA-SPVAVHQDLVHHWTASNQTFCWENwpEKQQKPVYVVCT 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  194 IVVNFIVPLTVMFYCYYHVSRslrlyaasdctaHLH---RDWADQAD-----VTKMSVIMILMFLLAWSPYSIVCLWACF 265
Cdd:cd15098 173 FVFGYLLPLLLITFCYAKVLN------------HLHkklKNMSKKSErskkkTAQTVLVVVVVFGISWLPHHIIHLWVEF 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 3024316  266 GNpkkIPPSMA-----IIAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15098 241 GD---FPLTQAsfvlrITAHCLAYANSCVNPIIYAFLSENFRKA 281
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
28-305 2.83e-12

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 65.98  E-value: 2.83e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   28 IAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIF 107
Cdd:cd15054   3 VAAFLCLIILLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWYAFDVM 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  108 FGMVSIGLLTVVAMDRYLTISCP-DVGRRMTTNTYLSMILGAWINGLFWALMPI-IGWASYAPDPTGATCTINWRNNDTS 185
Cdd:cd15054  83 CCSASILNLCVISLDRYLLIISPlRYKLRMTPPRALALILAAWTLAALASFLPIeLGWHELGHERTLPNLTSGTVEGQCR 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  186 FV---SYTMMVIVVNFIVPLTVMFYCYyhvsrslrlyaasdCTAHLHRDWADQADVTKMsvIMILMFLLAWSPYSIVCLW 262
Cdd:cd15054 163 LLvslPYALVASCLTFFLPSGAICFTY--------------CRILLAARKALKASLTLG--ILLGMFFVTWLPFFVANVV 226
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 3024316  263 ACFGNPkkIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKAM 305
Cdd:cd15054 227 QAVCDC--VSPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 267
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
22-296 3.05e-12

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 65.72  E-value: 3.05e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   22 RTEHSVIAAYLIVAgitsILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIY 101
Cdd:cd15196   1 KVEIAVLATILVLA----LFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVALFNVLPQLIWDITYRFYGGDLLCRLV 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  102 AGLNIFFGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTGATCTINwRN 181
Cdd:cd15196  77 KYLQVVGMYASSYVLVATAIDRYIAICHPLSSHRWTSRRVHLMVAIAWVLSLLLSIPQLFIFSYQEVGSGVYDCWAT-FE 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  182 NDTSFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLrlyaasdctahlhrdWADQADVTKMSVIMILMFLLAWSPYSIVCL 261
Cdd:cd15196 156 PPWGLRAYITWFTVAVFVVPLIILAFCYGRICYVV---------------WRAKIKTVKLTLVVVACYIVCWTPFFVVQM 220
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 3024316  262 WACFG-NPKKIPPSMAIIApLFAKSSTFYNPCIYVA 296
Cdd:cd15196 221 WAAWDpTAPIEGPAFVIIM-LLASLNSCTNPWIYLA 255
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
26-303 4.12e-12

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 65.57  E-value: 4.12e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   26 SVIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIgVSSIGYPMSAASDLHG-SWKFGHAGCQIYAGL 104
Cdd:cd15189   1 RIIPPFIFSLCLFGLLGNLFVLLVFLLHRRRLTVAEIYLGNLAAADL-VFVSGLPFWAMNILNQfNWPFGELLCRVVNGV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  105 NIFFGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMI-LGAWINGLFWAL-MPIIGWASYAPDPTGATCTINWRNN 182
Cdd:cd15189  80 IKVNLYTSIYLLVMISQDRYLALVKTMAARRLRRRRYAKLIcVLIWVVGLLLSIpTFLLRKIKAIPDLNITACVLLYPHE 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  183 DTSFvSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRlyaasdcTAHLHRDWADQAD--VTKMSVIMILMFLLAWSPYSIV- 259
Cdd:cd15189 160 AWHF-AHIVLLNIVGFLLPLLVITFCNYNILQALR-------TREESTRCEDRNDskATALVLAVTLLFLVCWGPYHFFt 231
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 3024316  260 -------------CLWACFGNpkkippSMAIIAPLFAKSSTFYNPCIYVAAHKKFRK 303
Cdd:cd15189 232 fldflfdvgvldeCFWEHFID------IGLQLAVFLAFSNSCLNPVLYVFVGRYFRR 282
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
37-303 4.44e-12

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 65.66  E-value: 4.44e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   37 ITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIgVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLnIFFGMVS-IGL 115
Cdd:cd15183  12 IIGVVGNVLVVLVLIQHKRLRNMTSIYLFNLAISDL-VFLFTLPFWIDYKLKDDWIFGDAMCKFLSGF-YYLGLYSeIFF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  116 LTVVAMDRYLTISCPDVGRRMTTNTYlsmilGAWINGLFWAL-----MPIIGWASYAPDPTGATCTINW-RNNDTSFVSY 189
Cdd:cd15183  90 IILLTIDRYLAIVHAVFALRARTVTF-----GIITSIITWALailasMPCLYFFKSQWEFTHHTCSAHFpRKSLIRWKRF 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  190 TMMVI-VVNFIVPLTVMFYCYYHVSRSLrlyaasdctahLHRDWADQADVTKMSVIMILMFLLAWSPYSIVCLWACFGN- 267
Cdd:cd15183 165 QALKLnLLGLILPLLVMIICYTGIINIL-----------LRRPNEKKAKAVRLIFVITLLFFLLWTPYNLAAFVSAFQDv 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 3024316  268 --------PKKIPPSMAIIAPLfAKSSTFYNPCIYVAAHKKFRK 303
Cdd:cd15183 234 lftpsceqSQQLDLALQVTEVI-AYTHCCVNPVIYVFVGERFRK 276
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
37-216 4.52e-12

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 65.56  E-value: 4.52e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   37 ITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIgVSSIGYPMSAASDLHGsWKFGHAGCQ-IYA--GLNIFFGMVsi 113
Cdd:cd15175  12 FLGLLGNGLVILTYIYFKRLKTMTDIYLLNLALADI-LFLLTLPFWAASAAKK-WVFGEEMCKaVYClyKMSFFSGML-- 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  114 gLLTVVAMDRYLTIS-CPDVGRRMTTNTYLSMI--LGAWINGLFWAlMPIIGWASYAPDPTGATCTINWRNNDTSFVSYT 190
Cdd:cd15175  88 -LLMCISIDRYFAIVqAASAHRHRSRAVFISKVssLGVWVLAFILS-IPELLYSGVNNNDGNGTCSIFTNNKQTLSVKIQ 165
                       170       180
                ....*....|....*....|....*.
gi 3024316  191 MMVIVVNFIVPLTVMFYCYYHVSRSL 216
Cdd:cd15175 166 ISQMVLGFLVPLVVMSFCYSVIIKTL 191
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
29-304 5.73e-12

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 65.06  E-value: 5.73e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   29 AAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLH-GSWKFGHAGCQIYAGLNIF 107
Cdd:cd15053   4 ALFLLLLPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVYVEVNgGKWYLGPILCDIYIAMDVM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  108 FGMVSIGLLTVVAMDRYLTISCP-------DVGRRMTTNTylsmilgawingLFWALMPIIGwasyAPDPTGATCTINWR 180
Cdd:cd15053  84 CSTASIFNLCAISIDRYIAVTQPikyarqkNSKRVLLTIA------------IVWVVSAAIA----CPLLFGLNNVPYRD 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  181 NNDTSFVSYTMMVI--VVNFIVPLTVMFYCYYHVSRSLRlyaasdctahlhrdwaDQADVTKMSVIMILMFLLAWSPYSI 258
Cdd:cd15053 148 PEECRFYNPDFIIYssISSFYIPCIVMLLLYYRIFRALR----------------REKKATKTLAIVLGVFLFCWLPFFT 211
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 3024316  259 VCLW--ACFGNPKK---IPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15053 212 LNILnaICPKLQNQschVGPALFSLTTWLGYVNSFLNPIIYTIFNIEFRKA 262
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
37-258 7.70e-12

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 64.76  E-value: 7.70e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   37 ITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIgVSSIGYPMSAASD-LHGSWKFGHAGCQIYAGLNIFFGMVSIGL 115
Cdd:cd15192  12 VVGIFGNSLVVIVIYCYMKLKTVANIFLLNLALADL-CFLITLPLWAAYTaMEYHWPFGNFLCKIASALVSFNLYASVFL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  116 LTVVAMDRYLTISCPDVGRRMTTNTYLSMI-LGAWINGlFWALMPIIGW--ASYAPDPTGATCTINWRNNDTSF-VSYTM 191
Cdd:cd15192  91 LTCLSIDRYLAIVHPMKSRLRRTLVVARVTcIVIWLLA-GVASLPAIIHrdVFFIENTNITVCAFHYPSQNSTLlVGLGL 169
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 3024316  192 MVIVVNFIVPLTVMFYCYYHVSRSLRLyaasdcTAHLHRDWADQADVTKMSVIMILMFLLAWSPYSI 258
Cdd:cd15192 170 MKNLLGFLIPFLIILTCYTLIGKALKK------AYEIQRNKPRNDEIFKMIMAVVLFFFFCWIPHQI 230
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
27-312 9.46e-12

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 64.58  E-value: 9.46e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNI 106
Cdd:cd15299   5 LIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDY 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILG-AWINGLFWALMPIIGWASYAPDPT--GATCTINWRNND 183
Cdd:cd15299  85 VASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGlAWVISFVLWAPAILFWQYFVGKRTvpPDECFIQFLSEP 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  184 TsfvsYTMMVIVVNFIVPLTVMFYCYYHVsrslrlyaasdctahlHRDWADQADVTKMSVIMILMFLLAWSPYSIVCLWA 263
Cdd:cd15299 165 I----ITFGTAIAAFYLPVTIMTILYWRI----------------YKETIKEKKAAQTLSAILLAFIITWTPYNIMVLVN 224
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 3024316  264 CFGNPkKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKAMLAMFKCQ 312
Cdd:cd15299 225 TFCDS-CIPKTYWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQ 272
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
28-212 1.02e-11

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 64.88  E-value: 1.02e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   28 IAAYLIVAGItsILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIF 107
Cdd:cd15957   5 IVMSLIVLAI--VFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILLKTWTFGNFWCEFWTSIDVL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  108 FGMVSIGLLTVVAMDRYLTISCP-DVGRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTGATCTINWRNND-TS 185
Cdd:cd15957  83 CVTASIETLCVIAVDRYFAITSPfKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYAEETCCDfFT 162
                       170       180
                ....*....|....*....|....*..
gi 3024316  186 FVSYTMMVIVVNFIVPLTVMFYCYYHV 212
Cdd:cd15957 163 NQAYAIASSIVSFYVPLVIMVFVYSRV 189
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
29-311 1.20e-11

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 64.16  E-value: 1.20e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   29 AAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHG-SWKFGHAGCQIYAGLNIF 107
Cdd:cd15305   4 ALLILIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAILYDyAWPLPRYLCPIWISLDVL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  108 FGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILGA-WINGLFWAL-MPIIGWASYAPDPTGATCTInwrnNDTS 185
Cdd:cd15305  84 FSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAvWTISIGISMpIPVIGLQDDEKVFVNGTCVL----NDEN 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  186 FVsytMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAASDctahlhrdwaDQADVTKMSVIMILMFLLAWSPY------SIV 259
Cdd:cd15305 160 FV---LIGSFVAFFIPLIIMVITYCLTIQVLQRQQAIN----------NERRASKVLGIVFFLFLIMWCPFfitnilSVL 226
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 3024316  260 CLWACfgnPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKAMLAMFKC 311
Cdd:cd15305 227 CKEAC---DQKLMEELLNVFVWVGYVSSGINPLVYTLFNKTYRRAFSNYIRC 275
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
26-275 1.61e-11

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 63.86  E-value: 1.61e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   26 SVIAAYLIVAGItSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIgYPMSAASDLHGSWKFGHAGCQIYAGLN 105
Cdd:cd15090   2 TIMALYSIVCVV-GLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMGTWPFGNILCKIVISID 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  106 IFFGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMilgawINGLFWAL-----MPIIGWASYAPDPTGATCTINWR 180
Cdd:cd15090  80 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKI-----VNVCNWILssaigLPVMFMATTKYRQGSIDCTLTFS 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  181 NNDTSFVS-YTMMVIVVNFIVPLTVMFYCYYHVsrSLRLYAASDCTAHLHRDwADQADVTKMSVIMILMFLLAWSPYSIV 259
Cdd:cd15090 155 HPSWYWENlLKICVFIFAFIMPVLIITVCYGLM--ILRLKSVRMLSGSKEKD-RNLRRITRMVLVVVAVFIVCWTPIHIY 231
                       250
                ....*....|....*.
gi 3024316  260 CLWACFGNpkkIPPSM 275
Cdd:cd15090 232 VIIKALVT---IPETT 244
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
27-302 2.31e-11

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 63.66  E-value: 2.31e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIgVSSIGYPMSAASDLHG-SWKFGHAGCQIYAG-- 103
Cdd:cd15380   2 VLPTFIIAICFFGLLGNLFVLFVFLLPRRRLTIAEIYLANLAASDL-VFVLGLPFWAENIRNQfNWPFGNFLCRVISGvi 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  104 -LNIFfgmVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMI-LGAWINGLFWALmPIIGWAS--YAPDPTGATCTINW 179
Cdd:cd15380  81 kANLF---ISIFLVVAISQDRYRTLVHTMTSRRQRSRRQAQVIcLLIWVFGGLLSI-PTFLFRSvkHVPDLNISACILLF 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  180 RNNDTSFVSYTMMVIVvNFIVPLTVMFYCYYHVSRSLRLYAASDCTAhlhrdWADQADVTKMSVIM--ILMFLLAWSPYS 257
Cdd:cd15380 157 PHEAWHFARRVELNIV-GFLLPLAAIVFFNFHIIASLRERTEESRKR-----CGGLKDTKATRLILtlVLMFLVCWTPYH 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 3024316  258 IV--------------CLWACFGNPKKippsmaIIAPLFAKSSTFYNPCIYVAAHKKFR 302
Cdd:cd15380 231 FFafldflfqveviqgCFWEEFIDLGL------QLANFFAFANSCLNPVIYVFAGKLFR 283
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
25-305 2.41e-11

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 63.60  E-value: 2.41e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   25 HSVIAAYLIVAGItsiLSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGL 104
Cdd:cd14977   3 IMSLSLVIFAVGI---IGNLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLLCVPLNAYNLLTKDWLFGDVMCKLVPFI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  105 NIFFGMVSIGLLTVVAMDRYLTISCPD----VGRRMTTNTYLSMIlgaWINGLFWALMPIIGW--ASYaPDPTGATCTIN 178
Cdd:cd14977  80 QVTSLGVTVFSLCALSIDRYRAAVNSMpmqtIGACLSTCVKLAVI---WVGSVLLAVPEAVLStvARE-SSLDNSSLTVC 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  179 WRNNDTSFVSY-----TMMVIVVNFIVPLTVMFYCYYHVSRSLRlYAASDCTAHLHRDWADQADVTKMSVIMILMFLLAW 253
Cdd:cd14977 156 IMKPSTPFAETypkarSWWLFGCYFCLPLAFTAVCYLLMARTLI-RAAKEYTRGTKKHMKQRRQLAKTVLCLVLVFAFCW 234
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 3024316  254 SPYSIV-CLWACFGNPKKIPPSMAI-IAPLFAKSSTFYNPCIYVAA----HKKFRKAM 305
Cdd:cd14977 235 LPEHISnILRATLYNEVLIDTRSTLdILDLIGQFLSFFNSCVNPIAlyllSEPFRRAF 292
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
27-303 2.53e-11

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 63.60  E-value: 2.53e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAgITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNI 106
Cdd:cd15397   3 LVVSYSLVM-AVGLLGNICLICVIARQKEKTNVTNILIANLSFSDILVCLVCLPFTVVYTLMDYWIFGEVLCKMTPFIQC 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSmILGAWINGLFWALmPIIGWA----------SYAPDPTG--AT 174
Cdd:cd15397  82 MSVTVSILSLVLIALERHQLIINPTGWKPSVSQAYLA-VVVIWMLACFISL-PFLAFHiltdepyknlSHFFAPLAdkAV 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  175 CTINWRNNDTSFVsYTMMVIVVNFIVPLTVMFYCYYHVSRSLRLYA-ASDCTAHLHRDWADQADVTKMSVIMILMFLLAW 253
Cdd:cd15397 160 CTESWPSEHHKLA-YTTWLLLFQYCLPLLFILVCYLRIYLRLRRRKdMLERRGEYNRRAGHSKRINVMLVSLVAAFALCW 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 3024316  254 SP---YSIVCLWacfgNPKKIPPS----MAIIAPLFAKSSTFYNPCIYVAAHKKFRK 303
Cdd:cd15397 239 LPlnvFNAIADW----NHEAIPHCqhnlIFSLCHLAAMASTCVNPIIYGFLNSNFKK 291
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
37-304 3.28e-11

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 62.96  E-value: 3.28e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   37 ITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMsaasDLHGSWK-----FGHAGCQIYAGLNIFFGMV 111
Cdd:cd15357  12 VVGVIGNLLVCLVILKHQNMKTPTNYYLFSLAVSDLLVLLFGMPL----EVYEMWSnypflFGPVGCYFKTALFETVCFA 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  112 SIGLLTVVAMDRYLTISCPDVGRRMTTNTY-LSMILGAWINGLFWALmPIIG----WASYAPD----PTGATCTI----- 177
Cdd:cd15357  88 SILSVTTVSVERYVAILHPFRAKLNSTRERaLKIIVVLWVLSVLFSI-PNTSihgiKLQYFPNgtliPDSATCTVvkplw 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  178 --NWRNNDTSFVSYtmmvivvnfIVPLTVMFYCYYHVSRSLR---LYAASDCTAHLHRdwADQADVTKMSVIMILMFLLA 252
Cdd:cd15357 167 iyNLIIQITSLLFY---------VLPMGVISVLYYLMGLKLRgdkSLEADEMNVNIQR--PSRKSVTKMLFVLVLVFAIC 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 3024316  253 WSPYSIVCLWACFGNPKKIPPSMA-----IIAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15357 236 WAPFHVDRLFFSFVVEWTEPLANVfnlihVVSGVFFYLSSAVNPIIYNLLSRRFRTA 292
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
32-304 3.57e-11

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 63.00  E-value: 3.57e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   32 LIVAGitsilsNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFGMV 111
Cdd:cd15958  13 LIVAG------NVLVIVAIGRTQRLQTLTNLFITSLACADLVMGLLVVPFGATLVVRGRWLYGSFFCELWTSVDVLCVTA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  112 SIGLLTVVAMDRYLTISCP-DVGRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTGATCTINWRNNDtsFVS-- 188
Cdd:cd15958  87 SIETLCVIAIDRYLAITSPfRYQSLLTRARAKGIVCTVWAISALVSFLPIMMHWWRDEDDQALKCYEDPGCCD--FVTnr 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  189 -YTMMVIVVNFIVPLTVMFYCYYHVSRSLR--LYAASDCTAHLHRDWADQADVTK--------------MSVIMILM--F 249
Cdd:cd15958 165 aYAIASSIISFYIPLLIMIFVYLRVYREAKkqIKKIDKCEGRFHNTLTGLGRKCKrrpsrilalreqkaLKTLGIIMgvF 244
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 3024316  250 LLAWSPYSIVCLWACFgNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAhKKFRKA 304
Cdd:cd15958 245 TLCWLPFFLVNVVNVF-NRELVPDWLFVFFNWLGYANSAFNPIIYCRS-PDFRKA 297
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
26-258 3.64e-11

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 62.80  E-value: 3.64e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   26 SVIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIgYPMSAASDLHGS-WKFGHAGCQIyAGL 104
Cdd:cd15161   1 ILFALFYILVFILAFPGNTLALWLFIHDRKSGTPSNVFLMHLAVADLSYVLI-LPMRLVYHLSGNhWPFGEVPCRL-AGF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  105 NIFFGM-VSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILGA-WINGLFwALMPIIGWASYAPDPTGATCTINWRNN 182
Cdd:cd15161  79 LFYLNMyASLYFLACISVDRFLAIVHPVKSMKIRKPLYAHVVCGFlWVIVTV-AMAPLLVSPQTVEVNNTTVCLQLYREK 157
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 3024316  183 DTSFvsyTMMVIVVNFIVPLTVMFYCYYHVSRSLRlyaasdCTAHLHRDWADQAdvTKMSVIMILMFLLAWSPYSI 258
Cdd:cd15161 158 ASRG---ALVSLAVAFTIPFVTTVTCYLLIIRSLR------TGKREEKPLKDKA--IKMIILVLTIFLICFVPYHI 222
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
40-259 4.59e-11

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 62.46  E-value: 4.59e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   40 ILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIgYPMSAASDLHGsWKFGHAGCQIYAGLNIFFGMVSIGLLTVV 119
Cdd:cd15181  15 VVGNGLVLTILLRRRRSRRTTENYLLHLALADLLLLLT-FPFSVVESIAG-WVFGTFLCKLVGAIHKLNFYCSSLLLACI 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  120 AMDRYLTI--SCPDVGRRMTTNTYLSmILGAWINGLFWALMPIIGW-ASYAPDPTGATCTINWRNNDTSFVSYTMMVI-- 194
Cdd:cd15181  93 SVDRYLAIvhAIHSYRHRRLRSVHLT-CGSIWLVCFLLSLPNLVFLeVETSTNANRTSCSFHQYGIHESNWWLTSRFLyh 171
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 3024316  195 VVNFIVPLTVMFYCYYHVSRSLRLYAASdctahlhrdwADQADVTKMSVIMILMFLLAWSPYSIV 259
Cdd:cd15181 172 VVGFFLPLLIMGYCYATIVVTLCQSSRR----------LQKQKAIRVAILVTLVFCLCWLPYNIV 226
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
27-305 5.20e-11

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 62.58  E-value: 5.20e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGItSILSNVVVLGIfIKYKELR--TPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGL 104
Cdd:cd15925   3 VALAYGLVCAI-GLLGNLAVMYL-LRNCARRapPPIDVFVFNLALADFGFALTLPFWAVESALDFHWPFGGAMCKMVLTA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  105 NIFFGMVSIGLLTVVAMDRYLTI-SCPDVGRRMTTNTYLSMILGAWINGLFwALMPIIGWASYAPDPTGATCTINWRNNd 183
Cdd:cd15925  81 TVLNVYASVFLLTAMSVTRYWVVaSAAGPGTHLSTFWAKIITLALWAAALL-ATVPTAIFATEGEVCGVELCLLKFPSN- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  184 TSFVSYTMMVIVVNFIVPLTVMFYCYyhvsrsLRLYAASDCTAHLHRDWADQADVTKMSVIMILMFLLAWSPYSIVCLWA 263
Cdd:cd15925 159 YWLGAYHLQRVVVAFVVPLGVITTSY------LLLLSFLQQHKVNQNNRQRQSVIARSVRLVVASFFLCWFPNHVVTFWG 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 3024316  264 CFGNPKKIPPSMAI------IAPL---FAKSSTFYNPCIYVAAHKKFRKAM 305
Cdd:cd15925 233 VLVKFRAVPWNSTFyfihtyVFPVttcLAHSNSCLNPVLYCLMRREFRQAL 283
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
31-256 5.44e-11

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 62.13  E-value: 5.44e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   31 YLIVAgITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDiGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFGM 110
Cdd:cd15972   7 YLVVC-VVGLGGNTLVIYVVLRYSASESVTNIYILNLALAD-ELFMLGLPFLAAQNALSYWPFGSFMCRLVMTVDAINQF 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  111 VSIGLLTVVAMDRYLTISCPDVGRRMTTNTylsmiLGAWINGLFWAL-----MPIIGWASYAPDptGATCTINWRNN--- 182
Cdd:cd15972  85 TSIFCLTVMSVDRYLAVVHPIRSSKWRKPP-----VAKTVNATVWALsflvvLPVVIFSGVPGG--MGTCHIAWPEPaqv 157
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 3024316  183 -DTSFVSYTMmviVVNFIVPLTVMFYCYYHVSRSLRlYAASDCTAHLHRDWADQADVTKMSVIMILMFLLAWSPY 256
Cdd:cd15972 158 wRAGFIIYTA---TLGFFCPLLVICLCYLLIVVKVR-SSGRRVRATSTKRRGSERKVTRMVVIVVAAFVLCWLPF 228
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
32-304 5.48e-11

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 61.95  E-value: 5.48e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   32 LIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDL-HGSWKFGHAGCQIYAGLNIFFGM 110
Cdd:cd15052   7 LLLLVIATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPLSILTELfGGVWPLPLVLCLLWVTLDVLFCT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  111 VSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSM-ILGAWINGLFWAL-MPIIGWASYAPDPTGATCTINWRNndtsFVS 188
Cdd:cd15052  87 ASIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLkIAIVWLISIGISSpIPVLGIIDTTNVLNNGTCVLFNPN----FVI 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  189 YTMmviVVNFIVPLTVMFYCYYHVSRSLRLyaasdctahlhrdwadQADVTKMSVIMILMFLLAWSPYSIVCLWA--CFG 266
Cdd:cd15052 163 YGS---IVAFFIPLLIMVVTYALTIRLLSN----------------EQKASKVLGIVFAVFVICWCPFFITNILTglCEE 223
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 3024316  267 NPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15052 224 CNCRISPWLLSVFVWLGYVSSTINPIIYTIFNKTFRRA 261
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
33-302 6.12e-11

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 62.10  E-value: 6.12e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   33 IVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFghAGCQIYAGLNIFFGMVS 112
Cdd:cd15070   8 ILIGLCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIPLAIVVSLGVTIHF--YSCLFMSCLLVVFTHAS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  113 IGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILG-AWINGLFWALMPIIGWASYAPDPTGATCTINWRNndTSFVSYTM 191
Cdd:cd15070  86 IMSLLAIAVDRYLRVKLTVRYRIVTTQRRIWLALGlCWLVSFLVGLTPMFGWNRKPSLESVNTTPLQCQF--TSVMRMDY 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  192 MVIVVNF---IVPLTVM----FYCYYHVSRSL--RLYAASDCTAHLHRDWadqaDVTKMSVIMILMFLLAWSPYSIVCLW 262
Cdd:cd15070 164 MVYFSFFtwiLIPLVIMcalyVDIFYIIRNKLsqNATGFRETGAFYGREF----KTAKSLALVLFLFAVCWLPLSIINCV 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 3024316  263 ACFgNPkKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFR 302
Cdd:cd15070 240 VYF-NP-KVPKIALYLGILLSHANSMMNPIVYACKIKKFK 277
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
27-304 7.48e-11

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 61.81  E-value: 7.48e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGitSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNI 106
Cdd:cd15324   4 VLVVVVIILV--TIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGSTWCAFYLALDV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGMVSIGLLTVVAMDRYLTIS-CPDVGRRMTTNTYLSMILGAWINGLFWALMPIIgwasyAPDPTGATCTInwrNNDTs 185
Cdd:cd15324  82 LFCTSSIVHLCAISLDRYWSVTkAVSYNLKRTPKRIKRMIAVVWVISAVISFPPLL-----MTKHDEWECLL---NDET- 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  186 fvSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRLyaasdctahlhrdwaDQADVTKMSVIMILMFLLAWSPYSIV-CLWAC 264
Cdd:cd15324 153 --WYILSSCTVSFFAPGLIMILVYCKIYRVAKM---------------REKRFTFVLAVVMGVFVLCWFPFFFTySLHAV 215
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 3024316  265 FGNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15324 216 CRKRCGIPDALFNLFFWIGYCNSSVNPIIYTIFNRDFRKA 255
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
28-293 7.66e-11

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 62.07  E-value: 7.66e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   28 IAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIgVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIF 107
Cdd:cd14999   2 IGTVLSLMCVVGVAGNVYTLVVMCLSMRPRASMYVYILNLALADL-LYLLTIPFYVSTYFLKKWYFGDVGCRLLFSLDFL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  108 FGMVSIGLLTVVAMDRYLTISCP-DVGRRMTTNTYLSMILgAWINGLFWALMPIIGWA---SYAPDPTGATCTINWRnND 183
Cdd:cd14999  81 TMHASIFTLTVMSTERYLAVVKPlDTVKRSKSYRKLLAGV-IWLLSLLLTLPMAIMIRlvtVEDKSGGSKRICLPTW-SE 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  184 TSFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAASDCTAHLHRdwADQADVTKMSVIMILMFLLAWSPYSIVCLWA 263
Cdd:cd14999 159 ESYKVYLTLLFSTSIVIPGLVIGYLYIRLARKYWLSQAAASNSSRKR--LPKQKVLKMIFTIVLVFWACFLPFWIWQLLY 236
                       250       260       270
                ....*....|....*....|....*....|
gi 3024316  264 CFGNPKKIPPSMAIIAPLFAKSSTFYNPCI 293
Cdd:cd14999 237 LYSPSLSLSPRTTTYVNYLLTCLTYSNSCI 266
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
29-304 8.21e-11

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 61.49  E-value: 8.21e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   29 AAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHG-SWKFGHAGCQIYAGLNIF 107
Cdd:cd15304   4 ALLTVIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGyRWPLPSKLCAVWIYLDVL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  108 FGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNT-YLSMILGAWINGLFWAL-MPIIGWASYAPDPTGATCTInwrnNDTS 185
Cdd:cd15304  84 FSTASIMHLCAISLDRYIAIRNPIHHSRFNSRTkAFLKIIAVWTISVGISMpIPVFGLQDDSKVFKEGSCLL----ADEN 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  186 FVsytMMVIVVNFIVPLTVMFYCYYHVSRSLRlyaasdctahlhRDWADQADVTKMSVIMILMFLLAWSPYSIVCLWACF 265
Cdd:cd15304 160 FV---LIGSFVAFFIPLTIMVITYFLTIKSLQ------------QSISNEQKASKVLGIVFFLFVVMWCPFFITNVMAVI 224
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 3024316  266 GNPKKIPPSMAIIAPLF---AKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15304 225 CKESCNEVVIGGLLNVFvwiGYLSSAVNPLVYTLFNKTYRSA 266
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
27-304 9.72e-11

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 61.30  E-value: 9.72e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGS-WKFGHAGCQIYAGLN 105
Cdd:cd15302   2 LLALITAILSIITVIGNILVLLSFYVDRNIRQPSNYFIASLAVSDLLIGLESMPFYTVYVLNGDyWPLGWVLCDLWLSVD 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  106 IFFGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNT-YLSMILGAWINGLFWALMPIIGWASYAPDPT---GATCTINWRN 181
Cdd:cd15302  82 YTVCLVSIYTVLLITIDRYCSVKIPAKYRNWRTPRkVLLIIAITWIIPALLFFISIFGWQYFTGQGRslpEGECYVQFMT 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  182 NDTsfvsYTMMVIVVNFIVPLTVMFYCYYHVSRSlrlyaasdctahlhrdwADQADVTKMSVIMIL-MFLLAWSPYSIVC 260
Cdd:cd15302 162 DPY----FNMGMYIGYYWTTLIVMLILYAGIYRA-----------------ANRARKALRTITFILgAFVICWTPYHILA 220
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 3024316  261 LWACF-GNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15302 221 TIYGFcEAPPCVNETLYTISYYLCYMNSPINPFCYALANQQFKKT 265
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
38-303 1.12e-10

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 61.37  E-value: 1.12e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   38 TSILSNVVVLGIFIKYKElRTPTNAVIINLAFTDIgVSSIGYPMSaasdLH-----GSWKFGHAGCQIYAGLNIFFGMVS 112
Cdd:cd15339  13 TGLVGNILVLFTIIRSRK-KTVPDIYVCNLAVADL-VHIIVMPFL----IHqwargGEWVFGSPLCTIITSLDTCNQFAC 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  113 IGLLTVVAMDRYLTISCP-DVGRRMTTNTYLSMILGAWInGLFWALMPIIGWASYAPDPTGA-TCTINWRNNDtSFVSYT 190
Cdd:cd15339  87 SAIMTAMSLDRYIALVHPfRLTSLRTRSKTIRINLLVWA-ASFILVLPVWVYAKVIKFRDGLeSCAFNLTSPD-DVLWYT 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  191 MMVIVVNFIVPLTVMFYCY----YHVSRSLR-LYAASDCTAHLHRDWADQAdvTKMSVIMILMFLLAWSPYSIVCLWacf 265
Cdd:cd15339 165 LYQTITTFFFPLPLILICYililCYTWEMYRkNKKAGRYNTSIPRQRVMRL--TKMVLVLVGVFLVSAAPYHVIQLV--- 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 3024316  266 gNPKKIPPSMAI-----IAPLFAKSSTFYNPCIYVAAHKKFRK 303
Cdd:cd15339 240 -NLSVSQPTLAFyvsyyLSICLSYASSSINPFLYILLSGNFRK 281
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
30-297 1.20e-10

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 61.37  E-value: 1.20e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   30 AYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSsigypMSAASDLH----GSWKFGHAGCQI---YA 102
Cdd:cd15121   5 AILSLAFILGFPGNLFVVWSVLCRMKKRSVTCILVLNLALADAAVL-----LTAPFFLHflsgGGWEFGSVVCKLchyVC 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  103 GLNIFfgmVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYL-SMILGAWINGLFWALmPIIGWASYAPDPTGATCTINWRN 181
Cdd:cd15121  80 GVSMY---ASIFLITLMSMDRCLAVAKPFLSQKMRTKRSVrALLLAIWIVAFLLSL-PMPFYRTVLKKNINMKLCIPYHP 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  182 NDTSFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRlyaasdcTAHLHRdwadQADVTKMSVIMILMFLLAWSPYSIVCL 261
Cdd:cd15121 156 SVGHEAFQYLFETITGFLLPFTAIVTCYSTIGRRLR-------SARFRR----KRRTNRLVVLIIATFALFWLPYHVVNL 224
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 3024316  262 WACFGNPKKIPPSMAIIAPL---------FAKSSTFYNPCIYVAA 297
Cdd:cd15121 225 IQVAGALQNQAGNASVLKAAklarpnvtaLAFLSSSVNPVLYAFA 269
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
26-294 1.20e-10

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 61.56  E-value: 1.20e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   26 SVIAAYLIVAgITSILSNVVVLGIFIKYKEL-RTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGL 104
Cdd:cd15382   2 VSIIVYSVLF-LIAAVGNLTVLLILLRNRRRkRSRVNILLMHLAIADLLVTFIMMPLEIGWAATVAWLAGDFLCRLMLFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  105 NIFFGMVSIGLLTVVAMDRYLTISCP----DVGRRMTTntylsMILGAWInGLFWALMP--IIGWASYAPDPTGAT-C-T 176
Cdd:cd15382  81 RAFGLYLSSFVLVCISLDRYFAILKPlrlsDARRRGRI-----MLAVAWV-ISFLCSIPqsFIFHVESHPCVTWFSqCvT 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  177 INWRNNDTSFVSYTMMVIVVNFIVPLTVMFYCY----YHVSRSLRLyAASDCTAHLHRDWADQADVT----------KMS 242
Cdd:cd15382 155 FNFFPSHDHELAYNIFNMITMYALPLIIIVFCYslilCEISRKSKE-KKEDVSEKSSSVRLRRSSVGllerarsrtlKMT 233
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 3024316  243 VIMILMFLLAWSPYSIVCLWACF--GNPKKIPPSMAIIAPLFAKSSTFYNPCIY 294
Cdd:cd15382 234 IVIVLVFIICWTPYFIMSLWYWFdrESASKVDPRIQKGLFLFAVSNSCMNPIVY 287
7tmA_PGE2_EP4 cd15142
prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G ...
27-216 1.21e-10

prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP4, also called prostanoid EP4 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Like the EP2 receptor, stimulation of the EP4 receptor by PGE2 causes cAMP accumulation through G(s) protein activation. Knockout studies in mice suggest that EP4 receptor may be involved in the maintenance of bone mass and fracture healing. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320270 [Multi-domain]  Cd Length: 302  Bit Score: 61.36  E-value: 1.21e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSILSNVVVLGIFIKYKElRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNI 106
Cdd:cd15142   5 TIPAVMFIFGVVGNLIAIVVLCKSRKEQK-ETTFYTLVCGLAVTDLLGTCLASPVTIATYLKGRWPGGQPLCEYFSFILL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGMVSIGLLTVVAMDRYLTISCP-----DVGRRMTTNTylsmILGAWINGLFWALMPIIGWASYAPDPTGATCTINWRN 181
Cdd:cd15142  84 FFSLSGLSIICAMSIERYLAINHAyfynhYVDKRLAGLT----LFAIYASNILFCALPSMGLGKSKLQYPKTWCFIDWRT 159
                       170       180       190
                ....*....|....*....|....*....|....*.
gi 3024316  182 NDTSFVSYTMM-VIVVNFIVPLTVMfyCYYHVSRSL 216
Cdd:cd15142 160 NVSVHAAYSYMyAGFSSLLILVTVL--CNVLVCGAL 193
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
40-302 1.28e-10

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 61.01  E-value: 1.28e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   40 ILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGS-WKFGHAGCQIYAGLNIFFGMVSIGLLTV 118
Cdd:cd15308  15 IAGNVLVCLSVCTERALKTTTNYFIVSLAVADLLLALLVLPLYVYSEFQGGvWTLSPVLCDALMTMDVMLCTASIFNLCA 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  119 VAMDRYLTISCP-DVGRRMTTNTYLSMILGAWINGLFWAlMPIIGWASYAPDPTGATCTInwrnNDTSFVSYTMmviVVN 197
Cdd:cd15308  95 ISVDRFIAVSVPlNYNRRQGSVRQLLLISATWILSFAVA-SPVIFGLNNVPNRDPAVCKL----EDNNYVVYSS---VCS 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  198 FIVPLTVMFYCYYHVSRSLrlyaasdctahlhrdwADQADVTKMSVIMILMFLLAWSPYSIVCLWACFGNPKKIPPSMAI 277
Cdd:cd15308 167 FFIPCPVMLVLYCAMFRGL----------------GRERKAMRVLPVVVGAFLFCWTPFFVVHITRALCESCSIPPQLIS 230
                       250       260
                ....*....|....*....|....*
gi 3024316  278 IAPLFAKSSTFYNPCIYVAAHKKFR 302
Cdd:cd15308 231 IVTWLGYVNSALNPVIYTVFNAEFR 255
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
37-304 1.45e-10

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 61.04  E-value: 1.45e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   37 ITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIyagLNIFFGM-VSIGL 115
Cdd:cd15978  12 LLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSAVCKT---ATYFMGIsVSVST 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  116 LTVVA--MDRYLTISCPDVGRRMTTNTY-LSMILGAWINGlFWALMPIIGWASYAP-----DPTGATCTINWRNNDTSFV 187
Cdd:cd15978  89 FNLVAisLERYSAICKPLKSRVWQTKSHaLKVIAATWCLS-FTIMLPYPIYSNLVPftrinNSTGNMCRLLWPNDVTQQS 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  188 SYTMMVIVVnFIVPLTVMFYCYYHVsrSLRLYAASDCTAHLHRdwadqadVTKMSVIMILMFLLAWSPYSIVCLWACFGN 267
Cdd:cd15978 168 WYIFLLLIL-FLIPGIVMMTAYGLI--SLELYRGIKFLMAKKR-------VIRMLIVIVILFFLCWTPIFSANAWRAFDT 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 3024316  268 -PKKIPPSMAIIA--PLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15978 238 rSADRLLSGAPISfiHLLSYTSACVNPIIYCFMNKRFRMG 277
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
40-304 1.46e-10

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 60.75  E-value: 1.46e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   40 ILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGS-WKFGHAGCQIYAGLNIFFGMVSIGLLTV 118
Cdd:cd15310  15 VFGNVLVCMAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGvWNFSRICCDVFVTLDVMMCTASILNLCA 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  119 VAMDRYLTISCPDVGRRMTTNTYLS----MILGAWINGlFWALMPIIGWASYAPDPTgaTCTInwrnNDTSFVSYTMmvi 194
Cdd:cd15310  95 ISIDRYTAVVMPVHYQHGTGQSSCRrvslMITAVWVLA-FAVSCPLLFGFNTTGDPT--VCSI----SNPDFVIYSS--- 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  195 VVNFIVPLTVMFYCYyhvsrsLRLYAAsdctahlhrdWADQADVTKMSVIMILMFLLAWSPYSIVCLWACFGNPKKIPPS 274
Cdd:cd15310 165 VVSFYLPFGVTLLVY------VRIYVV----------LLREKKATQMLAIVLGAFIVCWLPFFLTHILNTHCQACHVPPE 228
                       250       260       270
                ....*....|....*....|....*....|
gi 3024316  275 MAIIAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15310 229 LYSATTWLGYVNSALNPVIYTTFNIEFRRA 258
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
33-304 1.48e-10

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 61.03  E-value: 1.48e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   33 IVAGITSILSNVVVLGIFiKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFGMVS 112
Cdd:cd15055   9 SISLLTVLGNLLVIISIS-HFKQLHTPTNLLLLSLAVADFLVGLLVMPFSMIRSIETCWYFGDTFCKLHSSLDYILTSAS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  113 IGLLTVVAMDRYLTISCP-DVGRRMTTNTYLSMILGAWINGLFWALMPIIgwaSYAPDPTGAT-------CTInwrnndt 184
Cdd:cd15055  88 IFNLVLIAIDRYVAVCDPlLYPTKITIRRVKICICLCWFVSALYSSVLLY---DNLNQPGLIRynscygeCVV------- 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  185 sFVSYTMMVI--VVNFIVPLTVMFYCYyhvsrsLRLYAASDCTAHLHRDWADQADVTKMSV---------------IMIL 247
Cdd:cd15055 158 -VVNFIWGVVdlVLTFILPCTVMIVLY------MRIFVVARSQARAIRSHTAQVSLEGSSKkvskkserkaaktlgIVVG 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 3024316  248 MFLLAWSPYSIVCLwaCFGNPKKIPPSMAIIAPLFAKSSTFyNPCIYVAAHKKFRKA 304
Cdd:cd15055 231 VFLLCWLPYYIVSL--VDPYISTPSSVFDVLIWLGYFNSCL-NPLIYALFYPWFRKA 284
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
37-258 2.23e-10

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 60.60  E-value: 2.23e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   37 ITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFGMVSIGLL 116
Cdd:cd15395  12 ILGVSGNLALIIIILKQKEMHNVTNILIVNLSFSDLLMTIMCLPFTFVYTLMDHWVFGEAMCKLNSMVQCISITVSIFSL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  117 TVVAMDRYLTISCPDVGRRMTTNTYLSmILGAWINGLFWALmPIIGWASYAPDP-----------TGATCTINWRNNDTS 185
Cdd:cd15395  92 VLIAIERHQLIINPRGWRPNNRHAYVG-IAVIWVLAVLTSL-PFLIFQVLTDEPfknvnvsldayKGKYVCLDQFPSDTI 169
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 3024316  186 FVSYTMMVIVVNFIVPLTVMFYCYYHVsrSLRLYAASDCTAHLhRDWADQADVTKMSVIMIL----MFLLAWSPYSI 258
Cdd:cd15395 170 RLSYTTCLLVLQYFGPLCFIFICYLKI--YIRLKRRNNMMDKM-RDNKYRSSETKRINIMLIsivvAFAVCWLPLNI 243
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
29-311 2.46e-10

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 60.23  E-value: 2.46e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   29 AAYLIVAGIT-SILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGS-WKFGHAGCQIYAGLNI 106
Cdd:cd15306   3 AALLILMVIIpTIGGNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTILFEAmWPLPLVLCPIWLFLDV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGMVSIGLLTVVAMDRYLTISCP-DVGRRMTTNTYLSMILGAWINGLFWAL-MPIIGWASYAPDPTGATCTInwrnNDT 184
Cdd:cd15306  83 LFSTASIMHLCAISLDRYIAIKKPiQASQYNSRATAFIKITVVWLISIGIAIpVPIKGIETDVDNPNNITCVL----TKE 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  185 SFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAASdctahlhrdwaDQADVTKMSVIMILMFLLAWSPYSIVCLWAC 264
Cdd:cd15306 159 RFGDFILFGSLAAFFTPLAIMIVTYFLTIHALRKQTIT-----------NEQRASKVLGIVFFLFLLMWCPFFITNITSV 227
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 3024316  265 FGNP--KKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKAMLAMFKC 311
Cdd:cd15306 228 LCDScnQTTLQMLMEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITC 276
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
25-303 2.56e-10

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 60.30  E-value: 2.56e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   25 HSVIAAYLIVAGItSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGL 104
Cdd:cd15124   1 YAIPTVYGIIILI-GLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASRYLADEWLFGRVGCKLIPFI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  105 NIFFGMVSIGLLTVVAMDRYLTISCP-DVgrrMTTNTYLSMILGA---WINGLFWALmPIIGWASYAP------DPTGAT 174
Cdd:cd15124  80 QLTSVGVSVFTLTALSADRYKAIVRPmDI---QASNALMKICLKAaliWILSMLLAI-PEAVFSDLHPfydkstNKTFVS 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  175 CTINWRNNDTSFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAAS---DCTAHLHRDWADQADVTKMSVIMILMFLL 251
Cdd:cd15124 156 CAPYPHSNELHPKIHSMASFLIFYVIPLSIISVYYYFIAKNLIRSAYNlpvEGNVHVRRQIESRKRLAKTVLVFVGLFAF 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 3024316  252 AWSPYSIVCLWACFgNPKKIPPSMA-----IIAPLFAKSSTFYNPCIYVAAHKKFRK 303
Cdd:cd15124 236 CWLPNHIIYLYRSY-HYSEVDTSMLhfvssICARILAFTNSCVNPFALYLLSKSFRK 291
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
39-303 3.24e-10

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 60.18  E-value: 3.24e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   39 SILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFGMVSIGLLTV 118
Cdd:cd15205  14 ALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIPFTLLQNISSNWLGGAFMCKMVPFVQSTAVVTSILTMTC 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  119 VAMDRYLTISCPDVGRRMTTNTYLSMILGawingLFWALMPIIGWA-----------SYAPDPTGATCTINWRNNdTSFV 187
Cdd:cd15205  94 IAVERHQGIVHPLKMKWQYTNRRAFTMLG-----LVWIVSVIVGSPmlfvqqlevkyDFLYEKRHVCCLERWYSP-TQQK 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  188 SYTMMVIVVNFIVPLTVMFYCYYHVSRSL----RLYAASDCTAHLHRDWADQADVTKMSVIMILM----FLLAWSPYSIV 259
Cdd:cd15205 168 IYTTFILVILFLLPLTTMLFLYSRIGYELwikkRVGDASVLQTIHGIEMSKISRKKKRAVKMMVTvvllFAVCWAPFHVV 247
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 3024316  260 CLWACFGNPKKIPPSMAI-----IAPLFAKSSTFYNPCIYVAAHKKFRK 303
Cdd:cd15205 248 HMMIEYSNLENKYDGVTIklifaIVQLIGFSNSFNNPIVYAFMNENFKK 296
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
32-304 3.30e-10

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 60.08  E-value: 3.30e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   32 LIVAGITSILSNVVVLGIFIKYKELR-TPTNAVIINLAFTDIGVSsIGYPMSAASDLHGSWKFGHAG-CQIYAGLNIFFG 109
Cdd:cd15104   6 LAVLSPLIITGNLLVIVALLKLIRKKdTKSNCFLLNLAIADFLVG-LAIPGLATDELLSDGENTQKVlCLLRMCFVITSC 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  110 MVSIGLLTVVAMDRYLTISCP-DVGRRMTTNTYLSMILGAWINGLFWALMPIIgWASYAPDPTGATCtinwrnndtSFVS 188
Cdd:cd15104  85 AASVLSLAAIAFDRYLALKQPlRYKQIMTGKSAGALIAGLWLYSGLIGFLPLI-SPQFQQTSYKGKC---------SFFA 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  189 -----YTMMVIVVNFIVPLTVMFYCYYHVSRSLRLYA--------ASDCTAHLHRDWADqADVTKMSVIMILMFLLAWSP 255
Cdd:cd15104 155 afhprVLLVLSCMVFFPALLLFVFCYCDILKIARVHSraiykvehALARQIHPRRTLSD-FKAARTVAVLIGCFLLSWLP 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 3024316  256 YSIVCLWACFGNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15104 234 FQITGLVQALCDECKLYDVLEDYLWLLGLCNSLLNPWIYAFWQKEVRRA 282
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
30-262 3.88e-10

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 59.76  E-value: 3.88e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   30 AYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIgVSSIGYPMSAASDLHGsWKFGHAGCQIYAGLNIFFG 109
Cdd:cd15176   5 VFYTIALVVGLAGNSLVVAIYAYYKKLKTKTDVYILNLAVADL-LLLFTLPFWAADAVNG-WVLGTAMCKITSALYTMNF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  110 MVSIGLLTVVAMDRYLTIScpdvgrRMTTNTYLSMIlgAWINGLF-WALMPIIGWasyapdPTGATCTINWRNN-DTSFV 187
Cdd:cd15176  83 SCGMQFLACISVDRYVAIT------KATSRQFTGKH--CWIVCLCvWLLAILLSI------PDLVFSTVRENSDrYRCLP 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  188 SY------------TMMVIVVNFIVPLTVMFYCYYHVSRSL-RLYAASDCTAhlhrdwadqadvTKMSVIMILMFLLAWS 254
Cdd:cd15176 149 VFppslvtsakatiQILEVLLGFVLPFLVMVFCYSRVARALsRTPNVKKSRA------------LKVLLAVVGVFIVTQL 216

                ....*...
gi 3024316  255 PYSIVCLW 262
Cdd:cd15176 217 PYNVVKFY 224
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
39-303 4.18e-10

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 59.53  E-value: 4.18e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   39 SILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSsIGYPMSAASDLHG-SWKFGHA-------GCQIYAGLNIFFGM 110
Cdd:cd15964  14 AILGNVFVLLILLTSHYKLTVPRFLMCNLAFADFCMG-IYLLLIASVDLHTrSEYYNHAidwqtgpGCNTAGFFTVFASE 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  111 VSIGLLTVVAMDRYLTIS-CPDVGRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPdptgATCTINWRNNDTSFVSY 189
Cdd:cd15964  93 LSVYTLTVITLERWYAITfAMRLDRKIRLRHASAIMLGGWVFCFLLALLPLVGVSSYAK----VSICLPMDTETPLAQAY 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  190 TMMVIVVNfIVPLTVMFYCYYHVSRSLRlyaasdcTAHLHRDWADQADVTKMSVIMILMFlLAWSPYSIVCLWACFGNPK 269
Cdd:cd15964 169 IVFVLMLN-IIAFVIICACYIKIYITVR-------NPQYKSGDKDTKIAKRMAVLIFTDF-ICMAPISFYALSAILNKPL 239
                       250       260       270
                ....*....|....*....|....*....|....
gi 3024316  270 KIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRK 303
Cdd:cd15964 240 ITVSNSKILLVLFYPLNSCANPFLYAIFTKAFRR 273
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
29-261 4.29e-10

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 59.67  E-value: 4.29e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   29 AAYLIVAG--ITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNI 106
Cdd:cd15312   2 AMYLFMAGaiLLTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSMVRSVESCWYFGDLFCKIHSSLDM 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGMVSIGLLTVVAMDRYLTISCP-DVGRRMTTNTYLSMILGAWI------NGLFWALMPIIGWASYApdpTGATCTinw 179
Cdd:cd15312  82 MLSTTSIFHLCFIAVDRYYAVCDPlHYRTKITTPVIKVFLVISWSvpclfaFGVVFSEVNLEGIEDYV---ALVSCT--- 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  180 rnnDTSFVSYT----MMVIVVNFIVPLTVM--FYCY-YHVSRS---LRLYAASDCTAHLHRDWADQAD--VTKMSVIMIL 247
Cdd:cd15312 156 ---GSCVLIFNklwgVIASLIAFFIPGTVMigIYIKiFFVARKhakVINNRPSVTKGDSKNKLSKKKErkAAKTLSIVMG 232
                       250
                ....*....|....
gi 3024316  248 MFLLAWSPYSIVCL 261
Cdd:cd15312 233 VFLLCWLPFFVATL 246
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
27-305 4.44e-10

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 59.39  E-value: 4.44e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAV-IINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLN 105
Cdd:cd15219   1 LLAVLLVVVLVVSLLSNLLVLLCFLYSAELRKQVPGIfLLNLSFCNLLLTVLNMPFTLLGVVRNRQPFGDGFCQAVGFLE 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  106 IFFGMVSIGLLTVVAMDRYLTISCP-DVGRRMTTNTYLSMILGAWINGLFWALMPI-IGWASYApdPTGATCTINWRNND 183
Cdd:cd15219  81 TFLTSNAMLSMAALSIDRWIAVVFPlSYTSKMRYRDAALMVGYSWLHSLTFSLVALfLSWLGYS--SLYASCTLHLPREE 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  184 --TSFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAAsdctahlhrdwadqadvTKMSVIMILMFLLAWSPYSIVCL 261
Cdd:cd15219 159 erRRFAVFTAFFHAFTFLLSLLVLCVTYLKVLKVRRRQRA-----------------TKKISIFIGTFVLCFAPYVITRL 221
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 3024316  262 WACFgNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKAM 305
Cdd:cd15219 222 VELL-PFVTINRYWGIVSKCLTYSKAASDPFVYSLLRQQYRKVL 264
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
28-303 5.32e-10

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 59.52  E-value: 5.32e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   28 IAAYLIVAgITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIF 107
Cdd:cd15980   4 IASYLLIF-LLCMMGNGVVCFIVLRSKHMRTVTNLFILNLAISDLLVGIFCMPTTLLDNIIAGWPFGSTVCKMSGMVQGI 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  108 FGMVSIGLLTVVAMDRYLTISCPdVGRRMTTNTYLSMILGAWIngLFWALMPIIGWASYAPDPTGAT------------- 174
Cdd:cd15980  83 SVSASVFTLVAIAVDRFRCIVYP-FKQKLTISTAVVIIVIIWV--LAIAIMCPSAVMLHVQEEKNYRvvlgsqnktspvy 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  175 -CTINWRNNDTSFVsYTMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAASDCTAHLHRDW----ADQADVTKMSVIMILMF 249
Cdd:cd15980 160 wCREDWPNQEMRKI-YTTVLFANIYLAPLSLIVIMYARIGITLFKTAMPHTGKHNQEQRhvvsRKKQKVIKMLLIVALLF 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 3024316  250 LLAWSPYSIVCLWACFGNPKKIPPSMAII-----APLFAKSSTFYNPCIYVAAHKKFRK 303
Cdd:cd15980 239 ILSWLPLWTLMMLSDYANLSPNQLQIINIyiypfAHWLAFFNSSVNPIIYGFFNENFRR 297
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
27-305 7.62e-10

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 59.18  E-value: 7.62e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSILSNVVVLGIFIKyKELRTPTNAVIINLAFTDIGVS-----SIGYPMSAASDLHGSWKFGHAGCQIY 101
Cdd:cd14978   2 LYGYVLPVICIFGIIGNILNLVVLTR-KSMRSSTNVYLAALAVSDILVLlsalpLFLLPYIADYSSSFLSYFYAYFLPYI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  102 AGLNIFFGMVSIGLLTVVAMDRYLTISCPD-----VGRRMTTNTYLSMILGAWINGL--FWALMPIIGWASYAPDPTGAT 174
Cdd:cd14978  81 YPLANTFQTASVWLTVALTVERYIAVCHPLkartwCTPRRARRVILIIIIFSLLLNLprFFEYEVVECENCNNNSYYYVI 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  175 CTINWRNNDTSFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAASDCTAHLHRDWA-----DQADVTKMSVIMILMF 249
Cdd:cd14978 161 PTLLRQNETYLLKYYFWLYAIFVVLLPFILLLILNILLIRALRKSKKRRRLLRRRRRLLsrsqrRERRTTIMLIAVVIVF 240
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 3024316  250 LLAWSPYSIVCLWACFGNPKKIPPSMAIIAPL------FAKSSTFYnpcIYVAAHKKFRKAM 305
Cdd:cd14978 241 LICNLPAGILNILEAIFGESFLSPIYQLLGDIsnllvvLNSAVNFI---IYCLFSSKFRRTF 299
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
40-305 8.48e-10

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 58.93  E-value: 8.48e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   40 ILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIgVSSIGYPMSAASDLHGsWKFGHAGCQIYAGL-NIFFgMVSIGLLTV 118
Cdd:cd15180  15 LLGNGLVLAVLLQKRRNLSVTDTFILHLALADI-LLLVTLPFWAVQAVHG-WIFGTGLCKLAGAVfKINF-YCGIFLLAC 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  119 VAMDRYLTI--SCPDVGRRMTTNTYLSMILgAWingLFWALMPIIGW----ASYAPDPTGATCTINWRNNDTSFV-SYTM 191
Cdd:cd15180  92 ISFDRYLSIvhAVQMYSRKKPMLVHLSCLI-VW---LFCLLLSIPDFifleATKDPRQNKTECVHNFPQSDTYWWlALRL 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  192 MVIVVNFIVPLTVMFYCYYHVSRSLRlyaASDCTAHLHRdwadqadVTKMSVIMILMFLLAWSPYSIVCLWACFGNPKKI 271
Cdd:cd15180 168 LYHIVGFLLPLAVMVYCYTSILLRLL---RSSQGFQKQR-------AIRVIVAVVVVFFLCWTPYNIALLVDTLIDLSVL 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 3024316  272 PPSMAIIAPL-FAKSST--------FYNPCIYVAAHKKFRKAM 305
Cdd:cd15180 238 DRNCGTESRLdIALSVTsslgyfhcCLNPLLYAFVGVKFRRKL 280
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
37-305 9.58e-10

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 59.02  E-value: 9.58e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316    37 ITSILSNVVVLGIFIKYKeLRTPTNAVIINLAFTDIgVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFGMVSIGLL 116
Cdd:PHA03087  52 FFGLVGNIIVIYVLTKTK-IKTPMDIYLLNLAVSDL-LFVMTLPFQIYYYILFQWSFGEFACKIVSGLYYIGFYNSMNFI 129
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   117 TVVAMDRYLTISCPDVGRRMTTNTYLSMI-LGAWINGLFwALMPIIGWASYAPDPTGATCTINWRNNDTS---FVSYTMM 192
Cdd:PHA03087 130 TVMSVDRYIAIVHPVKSNKINTVKYGYIVsLVIWIISII-ETTPILFVYTTKKDHETLICCMFYNNKTMNwklFINFEIN 208
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   193 VIvvNFIVPLTVMFYCYYHVSRSLRLYAASDctahlhrdwaDQADVTKMSVIMILMFLLAWSPYSIVCLWACFGNPKKIP 272
Cdd:PHA03087 209 II--GMLIPLTILLYCYSKILITLKGINKSK----------KNKKAIKLVLIIVILFVIFWLPFNVSVFVYSLHILHFKS 276
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 3024316   273 PSMAI--------IAPLFAKSSTFYNPCIYVAAHKKFRKAM 305
Cdd:PHA03087 277 GCKAVkyiqyalhVTEIISLSHCCINPLIYAFVSEFFNKHK 317
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
28-304 9.80e-10

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 58.55  E-value: 9.80e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   28 IAAYLIVAGItSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHG--SWKFGHAGCQIYAGLN 105
Cdd:cd14995   4 TFLVLLICGV-GIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADLMVLVAAGLPNEIESLLGpdSWIYGYAGCLLITYLQ 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  106 IFFGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILGA-WINGL----FWALMPIIGWASYAPDpTGATCTinWR 180
Cdd:cd14995  83 YLGINASSLSITAFTIERYIAICHPMKAQFICTVSRAKKIICFvWIFTSlycsPWLFLLDLSIKHYGDD-IVVRCG--YK 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  181 NNDTSFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLrlyaasdctahlhrdWADQADVTKMSVIMILMFLLAWSPYSIVC 260
Cdd:cd14995 160 VSRHYYLPIYLADFVLFYVIPLLLAIVLYGLIGRIL---------------FSSRKQVTKMLAVVVVLFALLWMPYRTLV 224
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 3024316  261 LWACFGNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd14995 225 VYNSFASPPYLDLWFLLFCRTCIYLNSAINPILYNLMSQKFRAA 268
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
32-303 1.47e-09

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 58.05  E-value: 1.47e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   32 LIVAGITS---ILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFF 108
Cdd:cd15297   4 VLVAGSLSlvtIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVV 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  109 GMVSIGLLTVVAMDRYLTISCP-DVGRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPT--GATCTINWRNNdts 185
Cdd:cd15297  84 SNASVMNLLIISFDRYFCVTKPlTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGGRTvpEGECYIQFFSN--- 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  186 fVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLrlyaasdctahlhrdwADQADVTKMSVIMILMFLLAWSPYSIVCLWACF 265
Cdd:cd15297 161 -AAVTFGTAIAAFYLPVIIMTVLYWQISRAS----------------SREKKVTRTILAILLAFIITWTPYNVMVLINTF 223
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 3024316  266 GNPkKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRK 303
Cdd:cd15297 224 CAS-CIPNTVWTIGYWLCYINSTINPACYALCNATFKK 260
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
33-304 1.59e-09

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 57.65  E-value: 1.59e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   33 IVAGITSILSNVVVLGIFIKYKeLRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFGMVS 112
Cdd:cd15334   9 ILALMTTAINSLVITAIIVTRK-LHHPANYLICSLAVTDFLVAVLVMPFSIMYIVKETWIMGQVVCDIWLSVDITCCTCS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  113 IGLLTVVAMDRYLTIS-CPDVGRRMTTNTYLSMILGAWINGLFWALMPIIgWASYAPDPTGaTCTINWRNndtsfVSYTM 191
Cdd:cd15334  88 ILHLSAIALDRYRAITdAVEYARKRTPKHAGIMIAVVWIISIFISMPPLF-WRHQTTSRED-ECIIKHDH-----IVFTI 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  192 MVIVVNFIVPLTVMFYCYYHVSRslrlyAASdctahlhrdwADQADVTKMSVImILMFLLAWSPYSIVCLWACFGNPKKI 271
Cdd:cd15334 161 YSTFGAFYIPLALILILYYKIYR-----AAT----------RERKAATTLGLI-LGAFVICWLPFFVKEVIVNTCDSCYI 224
                       250       260       270
                ....*....|....*....|....*....|...
gi 3024316  272 PPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15334 225 SEEMSNFLTWLGYINSLINPLIYTIFNEDFKKA 257
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
29-261 1.69e-09

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 57.84  E-value: 1.69e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   29 AAYLIVAgITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIgVSSIGYPMSAASDLHGS-WKFGHAGCQIYAGlnIF 107
Cdd:cd15162   5 AVYTLVF-VVGLPANGMALWVLLFRTKKKAPAVIYMANLAIADL-LLVIWLPFKIAYHIHGNnWIFGEALCRLVTV--AF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  108 FGMV--SIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILGA-WINGLFWAL-MPIIGWASYAPDPTGATC--TINWRN 181
Cdd:cd15162  81 YGNMycSILLLTCISIDRYLAIVHPMGHRRLRARRYALGTCLAiWLLALLVTLpLYLVKQTIFLPALDITTChdVLPEQL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  182 NDTSFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRlyAASDCTAHLHRDWAdqadvTKMSVIMILMFLLAWSPYSIVCL 261
Cdd:cd15162 161 LVGDWFYYFLSLAIVGFLIPFILTASCYVATIRTLA--ALEDENSEKKKKRA-----IKLAATVLAIFIICFAPSNLLLL 233
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
27-304 2.20e-09

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 57.54  E-value: 2.20e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAgITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMsaasDLHGSWK-----FGHAGCQIY 101
Cdd:cd15133   3 VCLTYLLIF-VVGVVGNVLTCLVIARHKAMRTPTNYYLFSLAVSDLLVLLLGMPL----ELYELWQnypflLGSGGCYFK 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  102 AGLNIFFGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILGA-WINGLFWAL---MPIIGWASYAPDPTGATCTI 177
Cdd:cd15133  78 TFLFETVCLASILNVTALSVERYIAVVHPLAARTCSTRPRVTRVLGCvWGVSMLCALpntSLHGIKFLGSGVPASAQCTV 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  178 NwrnndTSFVSYTMMVIVVN---FIVPLTVMFYCYYHVSRSLRLYAASDCTAHLHRDWAD----------QADVTKMSVI 244
Cdd:cd15133 158 R-----KPQAIYNMIPQHTGhlfFVLPMAVISVLYLLMALRLARERGLDATGAGSKIGTRtgqllqhprtRAQVTKMLFI 232
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 3024316  245 MILMFLLAWSPY-------SIVCLWAcfGNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15133 233 LVVVFAICWAPFhidrlmwSFISDWT--DNLHEVFQYVHIISGVFFYLSSAVNPILYNLMSTRFREM 297
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
27-305 2.24e-09

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 57.60  E-value: 2.24e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTD--IGVssigYPMSAAS-DLH---------GSWKFG 94
Cdd:cd15137   2 VLRVFIWVVGIIALLGNLFVLIWRLKYKEENKVHSFLIKNLAIADflMGV----YLLIIASvDLYyrgvyikhdEEWRSS 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   95 HAgCQIYAGLNIFFGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILGAWINGLFWALMPIIGWAS----YA--- 167
Cdd:cd15137  78 WL-CTFAGFLATLSSEVSVLILTLITLDRFICIVFPFSGRRLGLRRAIIVLACIWLIGLLLAVLPLLPWDYfgnfYGrsg 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  168 ---------PDPTGatctinWRnndtsfvsYTMMV-IVVNFIVPLTVMF-YCYYHVS-RSLRLYAASDCTAHlhrdwaDQ 235
Cdd:cd15137 157 vclplhitdERPAG------WE--------YSVFVfLGLNFLAFVFILLsYIAMFISiRRTRKAAASRKSKR------DM 216
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 3024316  236 ADVTKMSVImILMFLLAWSPYSIVCLWACFGNPkkIPPSM-AIIAPLFAKSSTFYNPCIYVAAHKKFRKAM 305
Cdd:cd15137 217 AVAKRFFLI-VLTDFLCWIPIIVIGILALSGVP--IPGEVyAWVAVFVLPINSALNPILYTLSTPKFRKKL 284
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
27-305 2.40e-09

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 57.28  E-value: 2.40e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAgITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIgYPMSAASDLHGsWKFGHAGCQIYAGLN- 105
Cdd:cd15178   3 LCVIYVLVF-LLSLPGNSLVVLVILYNRRSRSSTDVYLLHLAIADLLFALT-LPFWAVSVVKG-WIFGTFMCKLVSLLQe 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  106 -IFFGmvSIGLLTVVAMDRYLTISCPDvgRRMTTNTYLSMI--LGAWINGLFWALMPIIGWASYAPDPTGAT-CTINWRN 181
Cdd:cd15178  80 aNFYS--GILLLACISVDRYLAIVHAT--RALTQKRHLVKFvcAGVWLLSLLLSLPALLNRDAFKPPNSGRTvCYENLGN 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  182 NDTSFVSYTMMVI--VVNFIVPLTVMFYCYYHVSRslRLYAASDCTAHlhrdwadqadvTKMSVIM--ILMFLLAWSPYS 257
Cdd:cd15178 156 ESADKWRVVLRILrhTLGFLLPLVVMLFCYGFTIK--TLLQTRSFQKH-----------RAMRVIFavVLAFLLCWLPYN 222
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 3024316  258 IVCLWACFGNPKKIPPS----MAIIAPLFAKSS-----TFYNPCIYVAAHKKFRKAM 305
Cdd:cd15178 223 VTVLIDTLMRTKLITETcelrNHVDVALYVTQIlgflhSCINPVLYAFIGQKFRNNL 279
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
27-275 3.61e-09

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 56.89  E-value: 3.61e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQiyagLNI 106
Cdd:cd15927   2 VVPILFALIFLVGVLGNGTLILIFLRNKSMRNVPNIFILSLALGDLLLLLTCVPFTSTIYTLDSWPFGEFLCK----LSE 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGMVSIGL----LTVVAMDRYLTISCP--DVGRRMTTNT--------YLSMILGAWiNGLFWALMPIIGwasyAPDPTG 172
Cdd:cd15927  78 FLKDTSIGVsvftLTALSADRYFAIVNPmrKHRSQATRRTlvtaasiwIVSILLAIP-EAIFSHVVTFTL----TDNQTI 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  173 ATCTINWRNNDTSFV-SYTMMVIVVNFIVPLTVMFYCYYHVSRSLrLYAASDCTAHLHRDWADQAD----VTKMSVIMIL 247
Cdd:cd15927 153 QICYPYPQELGPNYPkIMVLLRFLVYYLIPLLIIGVFYVLMARHL-IRSTRNIGSGQNQAAQRQIEarkkVAKTVLAFVV 231
                       250       260
                ....*....|....*....|....*...
gi 3024316  248 MFLLAWSPYSIVCLWACFGNPKKIPPSM 275
Cdd:cd15927 232 LFAVCWLPRHVFMLWFHFAPNGLVDYNA 259
7tmA_CCRL2 cd15171
CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G ...
40-265 5.18e-09

CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine (CC-motif) receptor-like 2 (CCRL2) is a member of the atypical chemokine receptor family. CCRL2, like other atypical receptors, has an alteration in the conserved DRYLAIV motif in the third intracellular loop, which is essential for GPCR coupling and signaling. CCR2L is expressed in most hematopoietic cells and many lymphoid organs as well as in heart and lung. CCRL2 was initially reported to promote chemotaxis and calcium fluxes in responses to chemokines (CCL2, CCL5, CCL7, and CCL8); however, these results are still controversial. More recently, chemerin, a chemotactic agonist of CMKLR1 (chemokine-like receptor-1) and GPR1, was identified as a novel non-signaling ligand for both human and mouse CCRL2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C).


Pssm-ID: 320299  Cd Length: 279  Bit Score: 56.38  E-value: 5.18e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   40 ILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIgVSSIGYPMSAASDLHGSwKFGHAGCQIYAGLNiFFGMVSIG----L 115
Cdd:cd15171  15 LLDNGLVVFILVKYKGLKHVENIYFLNLAVSNL-CFLLTLPFWAHAAWHGG-SLGNPTCKVLVALS-SVGLHSEAlfnvL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  116 LTVVAMDRYLTISCPDVGRRMTTNTYLSMILgAWINGLFWALMPIIgwaSYAP--DPTGATCTIN---WRNNDTSFVSY- 189
Cdd:cd15171  92 LTVQASRVFFHGRLASSARRVAPCGIIASVL-AWLTAFLVTLPEFV---FYKPqmDSQKSKCAFSrphFLPAEETFWKYf 167
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 3024316  190 -TMMVIVVNFIVPLTVMFYCYYHVSRSLRLYaasdctahlhrdwADQADVTKMSVIMILMFLLAWSPYSIVCLWACF 265
Cdd:cd15171 168 lTLKMNIVVLVFPLLVFIICCVQLRKTQRFR-------------ERQRDLSKLVFAIMVVFLLMWAPYNIALFLSAF 231
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
27-265 5.19e-09

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 56.53  E-value: 5.19e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAgITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPmSAASDLHG--SWKFGHAGCQI--YA 102
Cdd:cd14997   3 VSVVYGVIF-VVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMP-VALVETWArePWLLGEFMCKLvpFV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  103 GLNIFFGMVsiglLTVVAM--DRYLTISCPDVGRRMTTNTYLSMILGA-WINGLFWALmPIIGWASY---APDPTGATCT 176
Cdd:cd14997  81 ELTVAHASV----LTILAIsfERYYAICHPLQAKYVCTKRRALVIIALiWLLALLTSS-PVLFITEFkeeDFNDGTPVAV 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  177 INWRNNDTSFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAASD---CTAHLHRDWADQADVTKMSVIMILMFLLAW 253
Cdd:cd14997 156 CRTPADTFWKVAYILSTIVVFFVVPLAILSGLYSVICRRLVGHPALEsrrADAANRHTLRSRRQVVYMLITVVVLFFVCL 235
                       250
                ....*....|..
gi 3024316  254 SPYSIVCLWACF 265
Cdd:cd14997 236 LPFRVVTLWIIF 247
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
40-261 5.26e-09

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 56.36  E-value: 5.26e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   40 ILSNVVVLGIFIKYKELRTPTNA---VIINLAFTDIgVSSIGYPMSAASDL-HGSWKFGHAGCQIYAGLNIFFGMVSIGL 115
Cdd:cd15338  15 IIGNSIVIYTIVKKSKFRCQQTVpdiFIFNLSIVDL-LFLLGMPFLIHQLLgNGVWHFGETMCTLITALDTNSQITSTYI 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  116 LTVVAMDRYLTISCPdvgrrMTTNTYLSMILGAWINGLFWAL-----MPIIGWASYAPDPTGAT-CTINWRNNDTSFVSY 189
Cdd:cd15338  94 LTVMTLDRYLATVHP-----IRSTKIRTPRVAVAVICLVWILsllsiTPVWMYAGLMPLPDGSVgCALLLPNPETDTYWF 168
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 3024316  190 TMMVIVVNFIVPLTVMFYCYYhvsRSLRLYAASDCTAHLHRDWADQADVTKMSVIMILMFLLAWSPYSIVCL 261
Cdd:cd15338 169 TLYQFFLAFALPLVVICVVYF---KILQNMASTVAPLPQRSLRVRTKKVTRMAVAICLAFFICWAPFYILQL 237
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
27-303 5.27e-09

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 56.16  E-value: 5.27e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSILSNVVVLgIFIKYKELRTPTNAVIINLAFTDIgVSSIGYPMSAASDLHG-SWKFGHAGCQIY---A 102
Cdd:cd14974   2 VSLVLYALIFLLGLPGNGLVI-WVAGFKMKRTVNTVWFLNLALADF-LFCLFLPFLIVYIAMGhHWPFGSVLCKLNsfvI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  103 GLNIFfgmVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMI-LGAWINGLFWALmPIIGWASYAPDPTGATCTINWRN 181
Cdd:cd14974  80 SLNMF---ASVFLLTAISLDRCLLVLHPVWAQNHRTVRLASVVcVGIWILALVLSV-PYFVFRDTVTHHNGRSCNLTCVE 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  182 NDTsFVSYTMMVI-----VVNFIVPLTVMFYCYYHVSRSLRlyaasdctahlHRDWADQADVTKMSVIMILMFLLAWSPY 256
Cdd:cd14974 156 DYD-LRRSRHKALtvirfLCGFLLPLLIIAICYSVIAVKLR-----------RKRLAKSSKPLRVLLAVVVAFFLCWLPY 223
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 3024316  257 SIVCLWACfgNPKKIPPSMAIIAPLFAKSSTFYNPCI----YVAAHKKFRK 303
Cdd:cd14974 224 HVFALLEL--VAAAGLPEVVLLGLPLATGLAYFNSCLnpilYVFMGQDFRK 272
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
41-216 6.81e-09

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 55.91  E-value: 6.81e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   41 LSNVVVLGIFIKYKELRTPTNAVIINLAFTDIgVSSIGYPMSAASDLHGsWKFGHAGCQIYAG---LNIFFGMVsigLLT 117
Cdd:cd15174  16 VGNSLVVLIYTYYRRRKTMTDVYLLNLAIADL-LFLCTLPFWATAASSG-WVFGTFLCKVVNSmykINFYSCML---LLT 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  118 VVAMDRYLTIscpdVGRRMTTNTYLSMILGAWINGLF-WAL-----MPIIGWASYAPDPTGATCTINWRNND--TSFVSY 189
Cdd:cd15174  91 CISVDRYIAI----VQATKAHNSKNKRLLYSKLVCFFvWLLstilsLPEILFSQSKEEESVTTCTMVYPSNEsnRFKVAV 166
                       170       180
                ....*....|....*....|....*..
gi 3024316  190 TMMVIVVNFIVPLTVMFYCYYHVSRSL 216
Cdd:cd15174 167 LALKVTVGFFLPFVVMVICYTLIIHTL 193
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
37-303 7.11e-09

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 55.80  E-value: 7.11e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   37 ITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFGMVSIGLL 116
Cdd:cd15298  12 LVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  117 TVVAMDRYLTISCP-DVGRRMTTNTYLSMILGAWING--------LFWALmpIIGWASYAPDptgaTCTINWRNNDtsfv 187
Cdd:cd15298  92 LIISFDRYFCVTKPlTYPARRTTKMAGLMIAAAWVLSfvlwapaiLFWQF--VVGKRTVPDN----QCFIQFLSNP---- 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  188 SYTMMVIVVNFIVPLTVMFYCYYHVSRSLrlyaasdctahlhrdwADQADVTKMSVIMILMFLLAWSPYSIVCLWACFGN 267
Cdd:cd15298 162 AVTFGTAIAAFYLPVVIMTVLYIHISLAS----------------ARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQ 225
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 3024316  268 pKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRK 303
Cdd:cd15298 226 -SCIPDTVWSIGYWLCYVNSTINPACYALCNATFKK 260
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
33-305 7.60e-09

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 56.02  E-value: 7.60e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   33 IVAGITSILS---NVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFG 109
Cdd:cd15316   5 IVLGFGAVLAvfgNLLVMISILHFKQLHSPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGESFCTFHTCCDVSFC 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  110 MVSIGLLTVVAMDRYLTISCPDV-GRRMTTNTYLSMILGAWINGLFWALmPIIGWASYAPDPTGATCTINWRNNDTSFVS 188
Cdd:cd15316  85 YASLFHLCFISVDRYIAVTDPLVyPTKFTVSVSGICISVSWIFSLTYSF-SVFYTGVNDDGLEELVNALNCVGGCQIILN 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  189 YTMMVI-VVNFIVPLTVMFYCY-------YHVSRSLRLYAA---SDCTAHLHRDWADQADVTKMSVIMILMFLLAWSPYS 257
Cdd:cd15316 164 QNWVLVdFLLFFIPTFAMIILYgkiflvaKQQARKIEMTSSkaeSSSESYKDRVARRERKAAKTLGITVIAFLVSWLPYL 243
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 3024316  258 IVCLWACFGNpKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKAM 305
Cdd:cd15316 244 IDVLIDAFMN-FITPPYIYEICCWCAYYNSAMNPLIYALFYPWFRKAI 290
7tmA_GPR176 cd15006
orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; ...
33-305 7.62e-09

orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; GPR176 is a putative G protein-coupled receptor that belongs to the class A GPCR superfamily; no endogenous ligand for GPR176 has yet been identified. The class A rhodopsin-like GPCRs represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320135 [Multi-domain]  Cd Length: 289  Bit Score: 56.03  E-value: 7.62e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   33 IVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMS---AASDLHGSWKFGHAGCQIYAGLNIFFG 109
Cdd:cd15006   7 VVIFVGSLLGNFMVLWSTCRTSVFKSVTNRFIKNLACSGICASLVCVPFDivlSASPHCCWWIYTLLFCKVIKFLHKVFC 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  110 MVSIGLLTVVAMDRYLTISCPdVGRRMTTNTYLSMILGAWINGLFwALMPIIGWASYAPDPTGATCTINWRNNDTSFVsY 189
Cdd:cd15006  87 SVTVLSFAAIALDRYYSVLYP-LERKISDAKSRDLVIYIWAHAVV-ASVPVFAVTNVTDIYAMSTCTESWGYSLGHLV-Y 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  190 TMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAASDCTAHLHRD--------WADQ--ADVTKMSVIMILMFLLAWSPYSIV 259
Cdd:cd15006 164 VIIYNITTVILPVAVVFLFMILIRRALSASQKKKVIIAALRTpqntisipYVSQreAELHAMLLSMVLVFILCSVPYATL 243
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 3024316  260 CLWACFGNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKAM 305
Cdd:cd15006 244 VIYRTILNISDISVFLLLTAIWLPKVSLLANPLLFLTVNKSVRKCL 289
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
31-294 8.28e-09

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 55.51  E-value: 8.28e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   31 YLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIgVSSIGYPMSAASDLHGSWKF-GHAGCQIYAGLNIFFG 109
Cdd:cd14964   4 ILSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDL-LASLVVLVLFFLLGLTEASSrPQALCYLIYLLWYGAN 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  110 MVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLS-MILGAWINGLFWALMPIIGWAsyaPDPTGATCTINWRNNdTSFVS 188
Cdd:cd14964  83 LASIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRvIILGCWGVSLLLSIPPLVGKG---AIPRYNTLTGSCYLI-CTTIY 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  189 YTMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAASDCTAHLHRDWADQAdVTKMSVIMILMFLLAWSPYSIVCLWACFGNP 268
Cdd:cd14964 159 LTWGFLLVSFLLPLVAFLVIFSRIVLRLRRRVRAIRSAASLNTDKNLK-ATKSLLILVITFLLCWLPFSIVFILHALVAA 237
                       250       260
                ....*....|....*....|....*.
gi 3024316  269 KKIPPSMAIIAPLFAKSSTFYNPCIY 294
Cdd:cd14964 238 GQGLNLLSILANLLAVLASTLNPFIY 263
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
37-261 8.46e-09

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 55.58  E-value: 8.46e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   37 ITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTD-IGVSSIGYPMSAASDlhgSWKFGHAGCQIYAGLNIFFGMVSIGL 115
Cdd:cd15187  12 VFGLLGNSLVIWVLVACKKLRSMTDVYLLNLAASDlLFVFSLPFQAYYLLD---QWVFGNAMCKIVSGAYYIGFYSSMFF 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  116 LTVVAMDRYLTISCPDVGRRMTTNTYLSMI-LGAWINGLFwALMPIIGWASYAPDPTGATCTINWRNNDTSFVSYTMMVI 194
Cdd:cd15187  89 ITLMSIDRYLAIVHAVYALKVRTASHGTILsLALWLVAIL-ASVPLLVFYQVASEDGRLQCIPFYPGQGNSWKVFTNFEV 167
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 3024316  195 -VVNFIVPLTVMFYCYYHVSRSLRlyaasDCTAHlhrdwaDQADVTKMSVIMILMFLLAWSPYSIVCL 261
Cdd:cd15187 168 nILGLLIPFSILIFCYHNILRNLR-----RCHNQ------NKTKAIKLVFIVVIVFFLFWTPFNVVLF 224
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
37-304 9.28e-09

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 55.80  E-value: 9.28e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   37 ITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHG-SWKFGHAGCQIYAGLNIFFGMVSIGL 115
Cdd:cd15134  12 VTGVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILGLPFELYTIWQQyPWVFGEVFCKLRAFLSEMSSYASVLT 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  116 LTVVAMDRYLTISCPDVGRRMTT-NTYLSMILGAWINGLFWAL-MPIIGWASYAPDPTG--------ATCTINwrnndTS 185
Cdd:cd15134  92 ITAFSVERYLAICHPLRSHTMSKlSRAIRIIIAIWIIAFVCALpFAIQTRIVYLEYPPTsgealeesAFCAML-----NE 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  186 FVSYTMMVIV---VNFIVPLTVMFYCYYHV-----SRSLRLYAASDCTAHLHRDWADQAdVTKMSVIMILMFLLAWSPYS 257
Cdd:cd15134 167 IPPITPVFQLstfLFFIIPMIAIIVLYVLIglqlrRSTLLRRGQRSVSGGRRSSQSRRT-VLRMLVAVVVAFFICWAPFH 245
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 3024316  258 IVCLWACFGnPKKIPPSMAIIAPLFAKSSTFY------NPCIYVAAHKKFRKA 304
Cdd:cd15134 246 AQRLLTVYA-KNMTPPYLFINRILFYISGVLYyvsstvNPILYNVMSAKYRQA 297
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
37-294 9.95e-09

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 55.53  E-value: 9.95e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   37 ITSILSNVVVLGIFIKYKELRTptNAVIINLAFTDIGVSSIGYP--MSAASDLHGSWKFGHAGCQIYAGLNIFFGMVSIG 114
Cdd:cd15220  11 LTALVGNTAVMVVIAKTPHLRK--FAFVCHLCVVDLLAALLLMPlgILSSSPFFLGVVFGEAECRVYIFLSVCLVSASIL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  115 LLTVVAMDRYLTISCP-DVGRRMTTNTYLSMILGAWINGLFWALMPIIGWASY-APDPTGATCTINWRNNDTSFVSYTMM 192
Cdd:cd15220  89 TISAISVERYYYIVHPmRYEVKMTIGLVAAVLVGVWVKALLLGLLPVLGWPSYgGPAPIAARHCSLHWSHSGHRGVFVVL 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  193 VIVVNFIVPLTVMFYCYYHVSRSLRlyaasdctahlhrdwADQADVTkmSVIMILMFLLAWSPYSIVCLWACFGNPKKIP 272
Cdd:cd15220 169 FALVCFLLPLLLILVVYCGVFKVFG---------------GGKAALT--LAAIVGQFLCCWLPYFAFHLYSALAASPVSG 231
                       250       260
                ....*....|....*....|..
gi 3024316  273 PSMAIIAPLFAKSSTFYNPCIY 294
Cdd:cd15220 232 GEAEEVVTWLAYSCFAVNPFFY 253
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
37-303 1.02e-08

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 55.71  E-value: 1.02e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   37 ITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFghAGCQIYAGLNIFFGMVSIGLL 116
Cdd:cd15068  12 VLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAAC--HGCLFIACFVLVLTQSSIFSL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  117 TVVAMDRYLTISCPDVGRRMTTNTYLSMILG-AWINGLFWALMPIIGWASYAPDPTGATCTINWRNNDTS--FVSYTMMV 193
Cdd:cd15068  90 LAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAiCWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVAclFEDVVPMN 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  194 IVVNF------IVPLTVMFYCYYHVSRSLR-----LYAASDCTAHLHRDWADQADVTKMSVIMILMFLLAWSPYSIVCLW 262
Cdd:cd15068 170 YMVYFnffacvLVPLLLMLGVYLRIFLAARrqlkqMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCF 249
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 3024316  263 ACFGNPKKIPPSMAI-IAPLFAKSSTFYNPCIYVAAHKKFRK 303
Cdd:cd15068 250 TFFCPDCSHAPLWLMyLAIVLSHTNSVVNPFIYAYRIREFRQ 291
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
29-304 1.06e-08

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 55.62  E-value: 1.06e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   29 AAYL---IVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFghAGCQIYAGLN 105
Cdd:cd15071   1 AAYIgieVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAIIINIGPQTEF--YSCLMVACPV 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  106 IFFGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSM-ILGAWINGLFWALMPIIGW------------ASYAPDPTg 172
Cdd:cd15071  79 LILTQSSILALLAIAVDRYLRVKIPTRYKSVVTPRRAAVaIAGCWILSFLVGLTPMFGWnnlnaverawaaNSSMGELV- 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  173 ATCTINwrnndtSFVSYTMMViVVNFIV----PLTVMFYCYYHVSRSLRLYAASDCTAHL---HRDWADQADVTKMSVIM 245
Cdd:cd15071 158 IKCQFE------TVISMEYMV-YFNFFVwvlpPLLLMLLIYLEVFYLIRKQLNKKVSSSSsdpQKYYGKELKIAKSLALI 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 3024316  246 ILMFLLAWSPYSIVCLWACFGNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15071 231 LFLFALSWLPLHILNCITLFCPSCKKPMILTYIAIFLTHGNSAMNPIVYAFRIKKFRTT 289
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
37-305 1.20e-08

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 55.23  E-value: 1.20e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   37 ITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFGMVSIGLL 116
Cdd:cd15008  11 LVSVFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLLSVASAPFVLLQFTSGRWTLGSAMCKLVRYFQYLTPGVQIYVL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  117 TVVAMDRYLTISCPdVGRRMTTNTYLSMILGAWI-NGLFwaLMPIIGWASYAPDPtgatCTINWRNNDTSFVSYTMMVIV 195
Cdd:cd15008  91 LSICVDRFYTIVYP-LSFKVSREKAKKMIAASWLfDAAF--VSPALFFYGSNWGP----HCNFFLPDSWDGAAYAIIHLL 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  196 VNFIVPLTVMFYCYYHVSRSLRLYAASDCTAHLHRDWADQADVT--KMSVIMILMFLLAWSPYSIVCLWACFGNPKKIPP 273
Cdd:cd15008 164 VGFLVPSILIILFYQKVIKYIWRIGTDGRTVRRTMNIVPRTKVKtiKMFLMLNSMFLLSWLPFYVVQLWHPRESDYRQSS 243
                       250       260       270
                ....*....|....*....|....*....|..
gi 3024316  274 SMAIIAPLFAKSSTFYNPCIYVAAHKKFRKAM 305
Cdd:cd15008 244 LVFLAVTWISFSSSASKPTLYSVYNANFRRGM 275
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
26-303 1.46e-08

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 55.15  E-value: 1.46e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   26 SVIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIgVSSIGYPMSAASDLHG-SWKFGHAGCQIYAGL 104
Cdd:cd14991   1 SILPPLLILEFVLGLPGNVVALWIFCFHSRTWKANTVYLFNLVLADF-LLLICLPFRIDYYLRGeHWIFGEAWCRVNLFM 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  105 NIFFGMVSIGLLTVVAMDRYLTISCPdvgrRMTTNTyLSMILGAWINGLFWALM-----PIIGWASYAPDPTGATCTINW 179
Cdd:cd14991  80 LSVNRSASIAFLTAVALDRYFKVVHP----HHRVNR-MSVKAAAGVAGLLWALVllltlPLLLSTLLTVNSNKSSCHSFS 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  180 RNNDTSF-VSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAASDCTAHLHRdwadqadVTKMSVIMILMFLLAWSPYSI 258
Cdd:cd14991 155 SYTKPSLsIRWHNALFLLEFFLPLGLIVFCSVRIACNLRIRQSLGKQARVQR-------AIRLVFLVVIVFVLCFLPSII 227
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 3024316  259 VCLWACFGNPKKIPPSMAIIAPLFAKSSTF------YNPCIYVAAHKKFRK 303
Cdd:cd14991 228 AGLLALVFKNLGSCRCLNSVAQLFHISLAFtylnsaLDPVIYCFSSPWFRN 278
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
40-304 1.53e-08

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 54.66  E-value: 1.53e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   40 ILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFGMVSIGLLTVV 119
Cdd:cd15309  15 VFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRFSRIHCDIFVTLDVMMCTASILNLCAI 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  120 AMDRYLTISCPDV--GRRMTTNTYLSMILGAWINGLFWALMPIIGWAsyapDPTGATCTInwrnNDTSFVSYTMmviVVN 197
Cdd:cd15309  95 SIDRYTAVAMPMLynTRYSSKRRVTVMISVVWVLSFAISCPLLFGLN----NTDQNECII----ANPAFVVYSS---IVS 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  198 FIVPLTVMFYCYYHVSRSLRlyaasdctahlhrdwaDQADVTKMSVIMILMFLLAWSPYSIVCLWACFGNPkKIPPSMAI 277
Cdd:cd15309 164 FYVPFIVTLLVYVQIYIVLQ----------------KEKKATQMLAIVLGVFIICWLPFFITHILNMHCDC-NIPPALYS 226
                       250       260
                ....*....|....*....|....*..
gi 3024316  278 IAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15309 227 AFTWLGYVNSAVNPIIYTTFNIEFRKA 253
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
26-261 1.57e-08

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 54.80  E-value: 1.57e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   26 SVIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGyPMSAASDLHGSWKFGHAGCQIYAGLN 105
Cdd:cd14975   1 VLGCTLLSLAFAIGLPGNSFVIWSILIKVKQRSVTMLLVLNLALADLAVLLTL-PVWIYFLATGTWDFGLAACKGCVYVC 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  106 IFFGMVSIGLLTVVAMDRYLTISCPDVGRRM-TTNTYLSMILGAWINGLFWAlMPIIGWASYAPDPTGATCTINwRNNDT 184
Cdd:cd14975  80 AVSMYASVFLITLMSLERFLAVSRPFVSQGWrAKALAHKVLAIIWLLAVLLA-TPVIAFRHVEETVENGMCKYR-HYSDG 157
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 3024316  185 SFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRlyaasdctahlHRDWADQADVTKMSVIMILMFLLAWSPYSIVCL 261
Cdd:cd14975 158 QLVFHLLLETVVGFAVPFTAVVLCYSCLLRRLR-----------RRRFRRRRRTGRLIASVVVAFAACWLPYHVGNL 223
7tmA_SREB2_GPR85 cd15218
super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of ...
39-303 1.92e-08

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320346 [Multi-domain]  Cd Length: 330  Bit Score: 55.04  E-value: 1.92e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   39 SILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGS-WKFGHAGCQIYAGLNIFFGMVSIGLLT 117
Cdd:cd15218  14 SVVGNLLISILLVKDKTLHRAPYYFLLDLCCSDILRSAICFPFVFTSVKNGStWTYGTLTCKVIAFLGVLSCFHTAFMLF 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  118 VVAMDRYLTISCPDV-GRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTGATCTINWR----NNDTSFVSYTMM 192
Cdd:cd15218  94 CISVTRYLAIAHHRFyTKRLTFWTCLAVICMVWTLSVAMAFPPVLDVGTYSFIREEDQCTFQHRsfraNDSLGFMLLLAL 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  193 VIVVNFIVPLTVMFYCYYH-----------VSRSLRLY-------AASDCTAHLHR------------------------ 230
Cdd:cd15218 174 ILLATQLVYLKLIFFVHDRrkmkpvqfvaaVSQNWTFHgpgasgqAAANWLAGFGRgptpptllgirqnanttgrrrllv 253
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 3024316  231 --DWADQADVTKMSVIMILMFLLAWSPYSIVCLWACFGNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRK 303
Cdd:cd15218 254 ldEFKMEKRISRMFYIMTFLFLTLWGPYLVACYWRVFARGPVVPGGFLTAAVWMSFAQAGINPFVCIFSNRELRR 328
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
28-305 2.12e-08

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 54.48  E-value: 2.12e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   28 IAAYLIVAG--ITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLN 105
Cdd:cd15318   1 LVIYLACAIgmLIIVLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSVESCWYFGDSFCRLHTCLD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  106 IFFGMVSIGLLTVVAMDRYLTISCPDV-GRRMTTNTYLSMILGAWINGLFWALMPII------GWASYAPD-PTGATCTI 177
Cdd:cd15318  81 TLFCLTSIFHLCFISIDRHCAICDPLLyPSKFTIRVACIFIAAGWLVPTVYTSVFLYtkaveeGLAELLTSvPCVGSCQL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  178 NWrNNDTSFVSYTMmvivvnFIVPLTVMFYCYYHV----SRSLRLYAASdctAHLHRDWA-DQADVTKMSVIMILMFLLA 252
Cdd:cd15318 161 LY-NKLWGWLNFPV------FFIPCLIMIGLYVKIfivaKRQARAIASL---LSDTNGASkRERKAAKTLGIAVGVYLLC 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 3024316  253 WSPYSIVCLWACFGNpKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKAM 305
Cdd:cd15318 231 WLPFTIDTMVDSLLN-FITPPLLFDIIIWFAYFNSACNPLIYVFSYPWFRKAL 282
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
28-302 2.37e-08

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 54.55  E-value: 2.37e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   28 IAAYLIVAGItSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFghAGCQIYAGLNIF 107
Cdd:cd15069   4 VALELIIAAL-SVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDF--HSCLFLACFVLV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  108 FGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILGA-WINGLFWALMPIIGWASYApdpTGATCTINWRNNDTS- 185
Cdd:cd15069  81 LTQSSIFSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVlWVLAFGIGLTPFLGWNKAM---SATNNSTNPADHGTNh 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  186 --------FVSYTMMVIVVNF------IVPLTVMFYCYYHVSR-SLRLYAASDCTAHLHRDWADQADVTKMSVIMILMFL 250
Cdd:cd15069 158 scclisclFENVVPMSYMVYFnffgcvLPPLLIMLVIYIKIFLvACRQLQRTELMDHSRTTLQREIHAAKSLAIIVGIFA 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 3024316  251 LAWSPYSIV-CLWACFGNPKKIPPSMAI-IAPLFAKSSTFYNPCIYVAAHKKFR 302
Cdd:cd15069 238 LCWLPVHILnCITLFQPEFSKSKPKWAMnVAILLSHANSVVNPIVYAYRNRDFR 291
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
27-259 2.72e-08

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 54.37  E-value: 2.72e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIgVSSIGYPMSAASDLHG-SWKFGHAGCQIYAGLN 105
Cdd:cd15191   2 AIPVLYSIIFILGFLGNSLVVCVFCHQSGPKTVASIYIFNLAVADL-LFLATLPLWATYYSYGyNWLFGSVMCKICGSLL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  106 IFFGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTGAT-CTINWRNNDT 184
Cdd:cd15191  81 TLNLFASIFFITCMSVDRYLAVVYPLRSQRRRSWQARLVCLLVWVLACLSSLPTFYFRDTYYIEELGVNaCIMAFPNEKY 160
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 3024316  185 SFVSYTM--MVIVVNFIVPLTVMFYCYYHVSRSLRlyaasdCTAHLHRDWADQADVTKMSVIMILMFLLAWSPYSIV 259
Cdd:cd15191 161 AQWSAGLalMKNTLGFLIPLIVIATCYFGIGRHLL------KTKGFGKNKQRRDKVLKMVAAVVLAFLICWFPFHVL 231
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
27-303 2.95e-08

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 54.07  E-value: 2.95e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAgITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNI 106
Cdd:cd15396   3 LIIAYSVVT-IVGLFGNLCLITIIKKQKEEHNVTNILIANLSLSDVLVCVMCIPFTAVYTLMDHWIFGETMCKLTSFVQS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILgAWINGLFWALmPIIGWASYAPDP------------TGAT 174
Cdd:cd15396  82 VSVSVSIFSLVLIAIERYQLIVNPRGWKPSASHAYWGIVL-IWLFSLMISI-PFLIFHQLTDEPfrnlsshsdfykDKVV 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  175 CTINWrNNDTSFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSL-RLYAASDCTAHLHRDWADQADVTKMSVIMILMFLLAW 253
Cdd:cd15396 160 CIEAW-PSETERLIFTTSLLVFQYFVPLGFIFICYLKIFVCLkKRNSKIDRMRENESRLSENKRINTMLISIVVTFAACW 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 3024316  254 SPYSIV---------CLWACFGNpkkippSMAIIAPLFAKSSTFYNPCIYVAAHKKFRK 303
Cdd:cd15396 239 LPLNIFnvvfdwnheVLMSCHHN------LVFTLCHLVAMVSTCINPIFYGFLNKNFQK 291
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
57-267 4.95e-08

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 53.27  E-value: 4.95e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   57 RTPTNAVIINLAFTDiGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFGMVSIGLLTVVAMDRYLTISCPDVGRRM 136
Cdd:cd15122  34 RSVTCILILNLAVAD-GAVLLLTPFFITFLTRKTWPFGQAVCKAVYYLCCLSMYASIFIIGLMSLDRCLAVTRPYLAQSL 112
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  137 TTNTYLSMILGA-WINGLFWALMPIIGWASYAPDPTGATCTINWRNNDTSFVSYTMMVIVVNFIVPLTVMFYCYYHVSRS 215
Cdd:cd15122 113 RKKALVRKILLAiWLLALLLALPAFVYRHVWKDEGMNDRICEPCHASRGHAIFHYTFETLVAFVLPFGVILFSYSVILVR 192
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 3024316  216 LRlyaasdCTAHLHRdwadqADVTKMSVIMILMFLLAWSPYSIVCLWACFGN 267
Cdd:cd15122 193 LK------GARFRRR-----ARVEKLIAAIVVAFALLWVPYHVVNLLQVVAN 233
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
28-217 5.62e-08

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 53.26  E-value: 5.62e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   28 IAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIgVSSIGYPMSAASDL-HGSWKFGHAGCQIYAGLNI 106
Cdd:cd15199   3 YASLLILEFGLGLPGNAIALWTFIFRLKVWKPYAVYLLNLVLADV-LLLICLPFKAYFYLnGNRWSLGGGTCKALLFMLS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGMVSIGLLTVVAMDRYLTISCPdvgrRMTTNtYLSMILGAWINGLFWALM-PIIGWASYAPDPTGATCTINWRNNDTS 185
Cdd:cd15199  82 LSRGVSIAFLTAVALDRYFRVVHP----RGKKN-SLSLQAAPYISFLVWLLLvGLTIPTLLASQPKNFTECNSFSPKDDE 156
                       170       180       190
                ....*....|....*....|....*....|....
gi 3024316  186 FVSYTMMVIV--VNFIVPLTVMFYCYYHVSRSLR 217
Cdd:cd15199 157 DFSDTWQEAVffLQFLLPFGLIVFCTVRIIRRLK 190
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
26-304 5.76e-08

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 53.20  E-value: 5.76e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   26 SVIAAYLIVAGITSilsNVVVLGIFIKYKELRTPTNAVIINLAFTDiGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLN 105
Cdd:cd15087   4 PVIYSVICAVGLTG---NTAVIYVILRAPKMKTVTNVFILNLAIAD-DLFTLVLPINIAEHLLQQWPFGELLCKLILSID 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  106 IFFGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYlsmiLGAWINGL-FWAL-----MPIIGWAS-YAPDPTGATCTIN 178
Cdd:cd15087  80 HYNIFSSIYFLTVMSVDRYLVVLATVRSRRMPYRTY----RAAKIVSLcVWLLvtiivLPFTVFAGvYSNELGRKSCVLS 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  179 WRNNDTS-FVSYTMMVIVVNFIVPLTVMFYCYyhvsrSLRLYAASDCTAHLHRDWADQAD--VTKMSVIMILMFLLAWSP 255
Cdd:cd15087 156 FPSPESLwFKASRIYTLVLGFAIPVSTICILY-----TMMLYKLRNMRLNSNAKALDKAKkkVTLMVLVVLAVCLFCWTP 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 3024316  256 Y---SIVCLwacfgnPKKIPPSMAIIAPLFAKSSTFY-----NPCIYVAAHKKFRKA 304
Cdd:cd15087 231 FhlsTVVAL------TTDLPQTPLVIGISYFITSLSYansclNPFLYAFLDDSFRKS 281
7tmA_GPR88-like cd15211
G protein-coupled receptor 88, member of the class A family of seven-transmembrane G ...
37-304 5.99e-08

G protein-coupled receptor 88, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR88, an orphan G protein-coupled receptor, is predominantly and almost exclusively expressed within medium spiny neurons (MSNs) of the brain's striatum in both human and rodents; thus it is also called Striatum-specific GPCR (STRG). The striatum is known to involve in motor coordination, reward-based decision making, and response learning. GPR88 is shown to co-localize with both dopamine D1 and D2 receptors and displays the highest sequence similarity to receptors for biogenic amines such as dopamine and serotonin. GPR88 knockout mice showed abnormal behaviors observed in schizophrenia, such as disrupted sensorimotor gating, increased stereotypic behavior and locomotor activity in response to treatment with dopaminergic compounds such as apomorphine and amphetamine, respectively, suggesting a role for GPR88 in dopaminergic signaling. Furthermore, the transcriptional profiling studies showed that GPR88 expression is altered in a number of psychiatric disorders such as depression, drug addiction, bipolar and schizophrenia, providing further evidence that GPR88 plays an important role in CNS signaling pathways related to psychiatric disorder. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320339 [Multi-domain]  Cd Length: 283  Bit Score: 53.32  E-value: 5.99e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   37 ITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKfgHAGCQIYAGLNIFFGM-VSIGL 115
Cdd:cd15211  11 VSGTLANVLVIYLVVSFKKLQTTSNAFIVNGCVADLLVCAFWMPQEAVLGSTGTLL--VLGYRLFREGLLFLGLtVSLLS 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  116 LTVVAMDRYLTIS-CPDV-----GRRMTTntylSMILGAWINGLFwALMPIIGWASYAPDPTGATCTINWRNNDTSFVSY 189
Cdd:cd15211  89 HSLIALNRYVLITkLPAVyqalyQKRNTE----WMIALSWALALG-LLLPWLTSFRYPTKSCHDSADGSFAVVSVLSSRY 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  190 TMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAAS------DCTAHLHRDWADQADVTKMSVIMI-LMFLLAWSPYSIVCLW 262
Cdd:cd15211 164 PALLLAFTVLGQTALVLHCYFGIFRRVQISVKRvsvlnfQIVNNLPYSRPRKDKRLGLYVLLVcCVFLLTTEPLVWVSLA 243
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 3024316  263 ACFgnpKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15211 244 GLF---VPVPVALQTASWLLFCTLFVLNPFLYTWKNEEFRRS 282
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
30-259 6.57e-08

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 53.27  E-value: 6.57e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   30 AYLIVAgITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDI-GVSSIgyPMSAASDLHGS-WKFGHAGCQIYAGLNIF 107
Cdd:cd15921   6 AYILIF-ILGLTGNSISVYVFLSQYRSQTPVSVLMVNLAISDLlLVCTL--PLRLTYYVLNShWPFGDIACRIILYVLYV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  108 FGMVSIGLLTVVAMDRYLTISCPDVGRRMTTntylsmILGAWI-NGLFWALM-----PIIGWASYAPDPTGATCTINWRN 181
Cdd:cd15921  83 NMYSSIYFLTALSVFRYLALVWPYLYLRVQT------HSVAGIiCGLIWILMglassPLLFAKSKQHDEGSTRCLELAHD 156
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 3024316  182 NDTSFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRlyaasDCTAHLHRDWADQADVTKMSVIMILMFLLAWSPYSIV 259
Cdd:cd15921 157 AVDKLLLINYVTLPVGFVVPFMTVIFCYIFIIKNLL-----KPSPALGRTRPSRRKACALIIISLGIFLVCFLPYHIV 229
7tmA_FSH-R cd15360
follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G ...
37-303 7.00e-08

follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. FSH-R functions in gonad development and is found in the ovary, testis, and uterus. Defects in this receptor cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. The FSH-R activation couples to the G(s)-protein and stimulates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320482  Cd Length: 275  Bit Score: 52.94  E-value: 7.00e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   37 ITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSsIGYPMSAASDLHGS---------WKFGhAGCQIYAGLNIF 107
Cdd:cd15360  12 ILAITGNIVVLAILLTSQYKLTVPRFLMCNLAFADLCMG-IYLLLIASVDIRTKsqyynyaidWQTG-AGCAAAGFFTVF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  108 FGMVSIGLLTVVAMDRYLTIS-CPDVGRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTGATCTInwrnnDTSF 186
Cdd:cd15360  90 ASELSVYTLTVITLERWHTITyAMQLDRKVRLRHAAVIMVGGWIFAFTVALLPIFGISSYMKVSICLPMDI-----ESPL 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  187 VSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRlyaasdcTAHLHRDWADqADVTKMSVIMILMFLLAWSPYSIVCLWACFG 266
Cdd:cd15360 165 SQAYIIFILVLNVLAFLIICACYIKIYLTVR-------NPNFVSSNSD-TKIAKRMAVLIFTDFLCMAPISFFAISASLK 236
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 3024316  267 NPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRK 303
Cdd:cd15360 237 VPLITVSKSKILLVLFYPINSCANPFLYAIFTKTFRR 273
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
32-305 7.57e-08

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 52.85  E-value: 7.57e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   32 LIVAGITSILSNVVVlgIFIKYKELRTPTNAV-IINLAFTDIgVSSIGYPMSAASD-LHGSWKFGHAGCQIYAGLNIFFG 109
Cdd:cd15115   7 LSLTFLLGVPGNGLV--IWVAGLKMKRTVNTIwFLNLAVADL-LCCLSLPFSIAHLlLNGHWPYGRFLCKLLPSIIVLNM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  110 MVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILGA-WINGLFWALmPIIGWASYAPDPTGATCTINWrnndtsFVS 188
Cdd:cd15115  84 FASVFTLTAISLDRFLLVIKPVWAQNHRSVLLACLLCGCiWILALLLCL-PVFIYRTTVTDGNHTRCGYDF------LVA 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  189 YTMMVIVVNFIVPLTVMFYCYYHVSRSLRlyaasdctahLHRDWADQADVTKMSVIMILMFLLAWSPYSIVCLWACFGNP 268
Cdd:cd15115 157 ITITRAVFGFLLPLLIIAACYSFIAFRMQ----------RGRFAKSQSKTFRVIIAVVVAFFVCWAPYHIIGILSLYGDP 226
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 3024316  269 --KKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKAM 305
Cdd:cd15115 227 plSKVLMSWDHLSIALAYANSCLNPVLYVFMGKDFKKKA 265
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
37-158 7.87e-08

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 52.69  E-value: 7.87e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   37 ITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGC--QIYagLNIFFGMVSIG 114
Cdd:cd15915  12 LASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCisQLH--FFHFLGSSEAM 89
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 3024316  115 LLTVVAMDRYLTISCPdvgRR----MTTNTYLSMILGAWINGLFWALM 158
Cdd:cd15915  90 LLAVMAYDRYVAICNP---LRytviMNPQVCLLLAVACWVTGFFHALM 134
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
30-261 1.11e-07

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 52.45  E-value: 1.11e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   30 AYLIVAgITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIgVSSIGYPMSAASDlHGSWKFGHAGCQ----IYAgLN 105
Cdd:cd15172   6 IYSLIC-VVGLIGNSLVVITYAFYKRTKSMTDVYLLNMAIADI-LFVLTLPFWAVYE-AHQWIFGNFSCKllrgIYA-IN 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  106 IFFGMVsigLLTVVAMDRYLTISCPDVGRRMTTNT--YLSMI-LGAWINGLFWALMPIIGWASYAPDPTGAT-CTINWRN 181
Cdd:cd15172  82 FYSGML---LLACISVDRYIAIVQATKSFRLRSRTlaYSKLIcAAVWLLAILISLPTFIFSEVYDFGLEEQYvCEPKYPK 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  182 NDTSFVSYTMMVIV---VNFIVPLTVMFYCYYHVSRSLrLYAASdctahLHRDWAdqadvTKMSVIMILMFLLAWSPYSI 258
Cdd:cd15172 159 NSTAIMWKLLVLSLqvsLGFFIPLLVMIFCYSFIIKTL-LQAQN-----SQRHKA-----VRVVVAVVLVFLVCQVPYNI 227

                ...
gi 3024316  259 VCL 261
Cdd:cd15172 228 VLL 230
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
29-302 1.24e-07

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 52.32  E-value: 1.24e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   29 AAYLIVAgITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIgVSSIGYPMSAASDLHGS-WKFGHAGCQIYAGLNIF 107
Cdd:cd15168   5 IVYGVVF-LVGLLLNSVVLYRFIFHLKPWNSSAIYMFNLAVSDL-LYLLSLPFLIYYYANGDhWIFGDFMCKLVRFLFYF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  108 FGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILGA-WInGLFWALMPIIGWASYAPDPTGATCTINWRNND-TS 185
Cdd:cd15168  83 NLYGSILFLTCISVHRYLGICHPLRSLGKLKKRHAVAISVAvWI-LVLLQLLPILFFATTGRKNNRTTCYDTTSPEElND 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  186 FVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAASDCTAHLHRdwadqaDVTKMSVIMILMFLLAWSPYSIV------ 259
Cdd:cd15168 162 YVIYSMVLTGLGFLLPLLIILACYGLIVRALIRKLGEGVTSALRR------KSIRLVIIVLALFAVCFLPFHVTrtinla 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 3024316  260 --CLWACFGNPKKIPPSMA-IIAPLFAKSSTFYNPCIYVAAHKKFR 302
Cdd:cd15168 236 arLLSGTASCATLNGIYVAyKVTRPLASLNSCLNPLLYFLAGDKFR 281
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
39-305 1.37e-07

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 52.26  E-value: 1.37e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   39 SILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGS-WKFGHAGCQIYAGLNIFFGMVSIGLLT 117
Cdd:cd15217  14 SLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPFVLVSIRNGSaWTYSVLSCKIVAFMAVLFCFHAAFMLF 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  118 VVAMDRYLTISCPDV-GRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTGATCTINWR----NNDTSFVSYTMM 192
Cdd:cd15217  94 CISVTRYMAIAHHRFySKRMTFWTCIAVICMVWTLSVAMAFPPVFDVGTYKFIREEDQCIFEHRyfkaNDTLGFMLMLAV 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  193 VIVVNFIVPLTVMFYCYYH-----------VSRSLRLY-------AASDCTAHLHR------------------------ 230
Cdd:cd15217 174 LIVATHIVYGKLLLFEYRHrkmkpvqmvpaISQNWTFHgpgatgqAAANWIAGFGRgpmpptllgirqnahtanrrllgm 253
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 3024316  231 -DWADQADVTKMSVIMILMFLLAWSPYSIVCLWACFGNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKAM 305
Cdd:cd15217 254 eEFKAEKRLGRMFYVITLSFLVLWSPYIVACYWRVFVKACSIPHRYLSTAVWMSFAQAGVNPIVCFLLNKDLKKCL 329
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
27-295 1.51e-07

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 52.12  E-value: 1.51e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAgiTSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHG-SWKFGHAGCQIYAGLN 105
Cdd:cd15198   4 LIFLGVILV--AGVAGNTTVLCWLCGGRRRKSRMNFLLLQLALADLLVIGGTALSQIIWELLGdRWMAGDVACRLLKLLQ 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  106 IFFGMVSIGLLTVVAMDRYLTISCPdVGRRMTTNtylSMILGAWINGLFWALMPIIGWASYAPDPTgATCTINWRNNDTS 185
Cdd:cd15198  82 ASARGASANLVVLLALDRHQAIRAP-LGQPLRAW---KLAALGWLLALLLALPQAYVFRVDFPDDP-ASAWPGHTLCRGI 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  186 FVS--------YTMMVIVVNFIVPLTVMFYCYYHV--------------SRSLRLYAASDCTAHLHRDWAdQADVT--KM 241
Cdd:cd15198 157 FAPlprwhlqvYATYEAVVGFVAPVVILGVCYGRLllkwweranqapgaKKPWKKPSKSHLRATAPSALP-RAKVKtlKM 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 3024316  242 SVIMILMFLLAWSPYSIVCLWACFGNPKKIPPSMAIIAPLFAKSSTFYNPCIYV 295
Cdd:cd15198 236 TLVIALLFVGCSLPYFIAELAAAFGSGDWEPEKVAAALGVMAVANSATNPFVFL 289
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
28-303 1.52e-07

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 52.06  E-value: 1.52e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   28 IAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIgVSSIGYPMSAASD-LHGSWKFGHAGCQIYAGLNI 106
Cdd:cd15193   3 IPILYLIIFFTGLLGNLFVIALMSKRSTTKRLVDTFVLNLAVADL-VFVLTLPFWAASTaLGGQWLFGEGLCKLSSFIIA 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILGA-WINGLFWALMPIIgwasYAPDPTGATCtinWRNNDTS 185
Cdd:cd15193  82 VNRCSSILFLTGMSVDRYLAVVKLLDSRPLRTRRCALITCCIiWAVSLVLGIPSLV----YRNLINESVC---VEDSSSR 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  186 -FVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAasdctAHLHRDWADQADVTKMSVIMILMFLLAWSPY---SIVCL 261
Cdd:cd15193 155 fFQGISLATLFLTFVLPLIVILFCYCSILVRLRRHF-----HGAKRTGRRRRNSLRIVFAIVTAFVLSWLPFntlKAVRL 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 3024316  262 WACFGNpkKIPP---SMAI-----IAPLFAKSSTFYNPCIYVAAHKKFRK 303
Cdd:cd15193 230 LLELGG--GVLPchtTVAIrqgltITACLAFVNSCVNPLIYSLLDRHFRR 277
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
30-294 1.63e-07

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 52.04  E-value: 1.63e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   30 AYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFG 109
Cdd:cd15197   5 ATLWVLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGLINVLTDIIWRITVEWRAGDFACKVIRYLQVVVT 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  110 MVSIGLLTVVAMDRYLTISCP----DVGRRMTTntylsMILGAWI-NGLFWALMPIIgWASYAPDPTGATCTINWRNnDT 184
Cdd:cd15197  85 YASTYVLVALSIDRYDAICHPmnfsQSGRQARV-----LICVAWIlSALFSIPMLII-FEKTGLSNGEVQCWILWPE-PW 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  185 SFVSYTMMVIVVNFIVPLTVMFYCY-------------YHVSRSLRLYAASDCTAhLHRDWADQADV--TKMSVIMILMF 249
Cdd:cd15197 158 YWKVYMTIVAFLVFFIPATIISICYiiivrtiwkkskiQVTINKAGLHDGSSRRS-SSRGIIPRAKIktIKMTFVIVTVF 236
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 3024316  250 LLAWSPYSIVCLWACFGNpkkIPPS-MAIIAPLFAKS----STFYNPCIY 294
Cdd:cd15197 237 IICWSPYFVFDLLDVFGL---LPRSkTKIAAATFIQSlaplNSAINPLIY 283
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
27-217 2.05e-07

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 51.69  E-value: 2.05e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAgITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNI 106
Cdd:cd15398   3 LIGLYTFIS-LLGFLGNLLILTALTKKWKQKTIINFLIGNLAFSDILVVLFCSPFTLTCVLLDQWIFGEVMCHIVPFLQC 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGMVSIGLLTVVAMDRYLTISCPdVGRRMTTNTYLSMILGAWINGL--------FWALMPIIGWASYAPDPTGATCTIN 178
Cdd:cd15398  82 VSVMVSTLMLMSIAIVRYHMIKHP-LSNHLTANHGYFLLGTVWTLGFticsplpvFHKIVDLSETFNLESLKNKYLCIES 160
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 3024316  179 WrNNDTSFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLR 217
Cdd:cd15398 161 W-PSDSYRIAFTISLLFVQYILPLVCLTVSHTSVCRSVK 198
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
37-303 2.42e-07

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 51.37  E-value: 2.42e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   37 ITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIgVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFGMVSIGLL 116
Cdd:cd15185  12 IVGLLGNVVVVVILIKYRRLRIMTNIYLLNLAISDL-LFLFTLPFWIHYVRWNNWVFGHGMCKLLSGFYYLGLYSEIFFI 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  117 TVVAMDRYLTISCPDVGRRMTTNTY--LSMILgAWINGLFWALMPIIGWASYAPDPTGATCTINWRNNDTSFVSY-TMMV 193
Cdd:cd15185  91 ILLTIDRYLAIVHAVFALRARTVTFgiITSII-TWGLAVLAALPEFIFYETQELFEEFLCSPLYPEDTEDSWKRFhALRM 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  194 IVVNFIVPLTVMFYCYYHVSRSLrlyaasdctahLHRDWADQADVTKMSVIMILMFLLAWSPYSIVCLWACFG------- 266
Cdd:cd15185 170 NIFGLALPLLIMVICYTGIIKTL-----------LRCPSKKKYKAIRLIFVIMVVFFIFWTPYNLVLLLSAFQsiffetd 238
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 3024316  267 --NPKKIPPSMaIIAPLFAKSSTFYNPCIYVAAHKKFRK 303
Cdd:cd15185 239 ceRSKHLDLAM-QVTEVIAYTHCCINPVIYAFVGERFRK 276
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
34-305 2.70e-07

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 51.08  E-value: 2.70e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   34 VAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIgVSSIGYPMSAASDLHGSWKFGHAGCQIYAG---LNIFFGM 110
Cdd:cd15155   9 VVFILGLITNCASLFVFCFRMKMRNETAIFMTNLAVSDL-LFVFTLPFKIFYNFNRHWPFGDSLCKISGTaflTNIYGSM 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  111 VsigLLTVVAMDRYLTISCPDVGRRMTTNTYLSMIL-GAWI----NGLFWALMPIIGWASYAPDPTGATCTINWRnndTS 185
Cdd:cd15155  88 L---FLTCISVDRFLAIVYPFRSRTIRTRRNSAIVCaGVWIlvlsGGISASLFSTTNVSNTSTTCFEGFSKSIWK---TY 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  186 FVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRLyaasdcTAHLHRDWADQADVTKMSVIMILMFLLAWSPY-SIVCLWA- 263
Cdd:cd15155 162 LSKITIFIEVVGFIIPLLLNLTCSSLVLRTLRK------PATLSQIGTNKEKVLKMILVHVAIFVVCFVPYnSILFLYAl 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 3024316  264 --------CFgnPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKAM 305
Cdd:cd15155 236 vrsqaianCG--VERFARTMYPITLCLATLNCCFDPFVYYFTSESFQKSF 283
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
26-304 4.77e-07

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 50.56  E-value: 4.77e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   26 SVIAAYLIVAgitSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLN 105
Cdd:cd15296   4 AVLMALLVVA---TVLGNALVILAFVVDSSLRTQGNFFFLNLAISDFLVGGFCIPLYIPYVLTGRWKFGRGLCKLWLVVD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  106 IFFGMVSIGLLTVVAMDRYLTIS---CPDVGRRMTTNTYLSMILgAWINGLFWALMPIIGWASYAPD---PTG---ATCT 176
Cdd:cd15296  81 YLLCTASVFNIVLISYDRFLSVTravSYRAQKGMTRQAVLKMVL-VWVLAFLLYGPAIISWEYIAGGsiiPEGecyAEFF 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  177 INWrnndtsfvSYTMMVIVVNFIVPLTVMfyCYYHVSRSLRLYAASdctAHLHRDwadqADVTKMSVIMILMFLLAWSPY 256
Cdd:cd15296 160 YNW--------YFLMTASTLEFFTPFISV--TYFNLSIYLNIQKRR---FRLSRD----KKVAKSLAIIVCVFGLCWAPY 222
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 3024316  257 SIVCL--WACFGnpKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15296 223 TLLMIirAACHG--HCVPDYWYETSFWLLWVNSAINPVLYPLCHMSFRRA 270
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
26-302 5.15e-07

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 50.53  E-value: 5.15e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   26 SVIAAYLIVAGItsiLSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVsSIGYPMSAASDL-HGSWKFGHAGCQIYA-- 102
Cdd:cd14987   4 SFFYIFIFVIGL---LANSVVVWVNLQAKRTGYETHLYILNLAIADLCV-VATLPVWVVSLVqHNQWPMGEFTCKITHli 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  103 -GLNIFfgmVSIGLLTVVAMDRYLTISC-PDVGRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTGAT-CTINW 179
Cdd:cd14987  80 fSINLF---GSIFFLTCMSVDRYLSVTLfGNTSSRRKKIVRRIICVLVWLLAFVASLPDTYFLKTVTSPSNNETyCRSFY 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  180 --RNNDTSFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRlyAASDCTAHLHRdwadqadvtKMSVIMILMFLLAWSPYS 257
Cdd:cd14987 157 peESFKEWLIGMELVSIVLGFVIPFPIIAVFYFLLARAIS--ASSDQERKSSR---------KIIFSYVVVFLVCWLPYH 225
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 3024316  258 IVCLWACFGNPKKIPPSMAIIAPLFAK------SSTFY---NPCIYVAAHKKFR 302
Cdd:cd14987 226 TVVLLDILSFLHLIPFSCQLENFLYAAlhvtqcFSLVHccvNPILYSFINRNYR 279
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
56-158 5.99e-07

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 50.14  E-value: 5.99e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   56 LRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGC--QIYagLNIFFGMVSIGLLTVVAMDRYLTISCP-DV 132
Cdd:cd15227  31 LHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCvaQVF--LFIFFAASELALLTVMAYDRYVAICHPlHY 108
                        90       100
                ....*....|....*....|....*.
gi 3024316  133 GRRMTTNTYLSMILGAWINGLFWALM 158
Cdd:cd15227 109 EVIMNRGACVQMAAASWLSGLLYGAL 134
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
34-303 6.16e-07

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 50.15  E-value: 6.16e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   34 VAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIgYPMSAASDLHGsWKFGHAGCQIYAGLNIFFGMVSI 113
Cdd:cd15173   9 VMFVTGLVGNSLVIVIYIFYEKLRTLTDIFLVNLAVADLLFLCT-LPFWAYSAAHE-WIFGTVMCKITNGLYTINLYSSM 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  114 GLLTVVAMDRYLTIScpdVGRRMTTNTYLSMILGAWINGLFWALMPIIGWA----SYAPDPTGATCTINWRNNDTSFVsY 189
Cdd:cd15173  87 LILTCITVDRFIVIV---QATKAHNCHAKKMRWGKVVCTLVWVISLLLSLPqfiySEVRNLSSKICSMVYPPDAIEVV-V 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  190 TMMVIVVNFIVPLTVMFYCYYHVSRSLrlyaasdctahLHRDWADQADVTKMSVIMILMFLLAWSPYSIVCLWACFG--- 266
Cdd:cd15173 163 NIIQMTVGFFLPLLAMIICYSVIIKTL-----------LHAKGFQKHKSLKIIFVVVAVFILTQLPYNIMKLIRTLHien 231
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 3024316  267 NPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRK 303
Cdd:cd15173 232 TDSTNFKYAILITEAIAYLHACLNPILYAFVGVKFRK 268
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
25-295 6.16e-07

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 50.19  E-value: 6.16e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   25 HSVIAAYLIVAGItSILSNVVVLGIfIKYKELRTPTNAVIINLAFTDIGVSS----IGYPMSAASdlhgSWKFGHAGCQI 100
Cdd:cd15118   1 VATICLHGIVSTL-GIVENLLILWV-VGFRLRRTVISIWILNLALSDLLATLslpfFTYYLASGH----TWELGTTFCRI 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  101 YAG---LNIFfgmVSIGLLTVVAMDRYLTISCPdvgrrMTTNTYLSMILGAWINGLFWAL-------------------- 157
Cdd:cd15118  75 HSSiffLNMF---VSGFLLAAISLDRCLLVVKP-----VWAQNHRNVAAAKKICGVIWAMalintipyfvfrdvierkdg 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  158 --MPIIGWASYAPDPTGATCTINWRNndtsfVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRlyaasdctahlHRDWADQ 235
Cdd:cd15118 147 rkLCYYNFALFSPSPDNNHPICKQRQ-----EGLAISKLLLAFLIPLVIIAVSYAVVSLIIR-----------HRCRRRP 210
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 3024316  236 ADVTKMSVIMILMFLLAWSPYSIVCLWACFGNPKKIPPSMAIIAPLFAKSSTFY----NPCIYV 295
Cdd:cd15118 211 GRFVRLVVSVVVSFALCWAPYHIFSIIEVMAHNQHSLRPLVIQGLPFATTLAFLnsvlNPVLYV 274
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
30-260 9.94e-07

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 49.38  E-value: 9.94e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   30 AYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSsIGYPMSAASdLHGSWKFGHAGCQIYAGLNIFFG 109
Cdd:cd15923   5 AIYIPTFVLGLLLNILALWVFCWRLKKWTETNIYMTNLAVADLLLL-ISLPFKMHS-YRRESAGLQKLCNFVLSLYYINM 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  110 MVSIGLLTVVAMDRYLTISCPdvgrrMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTGATCTINWRNNDTSFVSY 189
Cdd:cd15923  83 YVSIFTITAISVDRYVAIRYP-----LRARELRSPRKAAVVCAVIWVLVVTISIPYFLLDSSNEKTMCFQRTKQTESLKV 157
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 3024316  190 TMMVIVVNFIVPLTVMFYCYYHVSRSLRlyaasdctahLHRDWADQADVTKMSVIMILMFLLAWspysIVC 260
Cdd:cd15923 158 FLLLEIFGFLLPLIIMTFCSARVIHTLQ----------KRLDDVGSRSETKQCIRVIMANLIVF----IVC 214
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
37-305 1.40e-06

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 49.08  E-value: 1.40e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   37 ITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIgVSSIGYPMSAASDLH-GSWKFGHAGCQIYAGLNIFFGMVSIGL 115
Cdd:cd15194  12 LVGAVGNAILMGALVFKRGVRRLIDIFISNLAASDF-IFLVTLPLWVDKEVVlGPWRSGSFLCKGSSYIISVNMYCSVFL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  116 LTVVAMDRYLTISCPDVGRRMTTNTY----------LSMILGAWIngLFWALMPIIGWASYAPDPTGATCTINWrnndts 185
Cdd:cd15194  91 LTCMSLDRYLAIVLPLVSRKFRTKHNakvcctcvwmLSCLLGLPT--LLSRELKKYEEKEYCNEDAGTPSKVIF------ 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  186 fvsyTMMVIVVNFIVPLTVMFYCYYHVSRSLrlyaasdcTAHLHRDWADQADV---TKMSVIMILMFLLAWSPYSIVCLW 262
Cdd:cd15194 163 ----SLVSLIVAFFLPLLSILTCYCTIIWKL--------CHHYQKSGKHQKKLrksIKIVFIVVAAFVFSWMPFNLFKAL 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 3024316  263 ACFGNPKKIPP---------SMAIIAPlFAKSSTFYNPCIYVAAHKKFRKAM 305
Cdd:cd15194 231 AIASGLQVEVTclpytlaqlGMEVSAP-LAFANSCANPFIYYFFDRYIRRAI 281
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
49-303 1.45e-06

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 48.94  E-value: 1.45e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   49 IFIKYKELRTPTNAV-IINLAFTDIgVSSIGYPMSAAS-DLHGSWKFGHAGCQIYAGLNIFFGMVSIGLLTVVAMDRYLT 126
Cdd:cd15114  22 AWVTGFEAKRSVNAVwFLNLAVADL-LCCLSLPILAVPiAQDGHWPFGAAACKLLPSLILLNMYASVLLLTAISADRCLL 100
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  127 ISCPdvgRRMTTNTYLsmiLGAWI-NGLFWALMPIIGWASYAPD-------PTGATCTINWRNNDTSFVSYTMMVIVVNF 198
Cdd:cd15114 101 VLRP---VWCQNHRRA---RLAWIaCGAAWLLALLLTVPSFIYRrihqehfPEKTVCVVDYGGSTGVEWAVAIIRFLLGF 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  199 IVPLTVMFYCYyhvsrslrlyaasdcTAHLHRDWADQAD----VTKMSVIMILMFLLAWSPYSIVCLWACFGNPKKIPPS 274
Cdd:cd15114 175 LGPLVVIASCH---------------GVLLVRTWSRRRQksrrTLKVVTAVVVGFFLCWTPYHVVGLIIAASAPNSRLLA 239
                       250       260       270
                ....*....|....*....|....*....|...
gi 3024316  275 MAIIA-PL---FAKSSTFYNPCIYVAAHKKFRK 303
Cdd:cd15114 240 NALKAdPLtvsLAYINSCLNPIIYVVAGRGFRK 272
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
31-259 1.80e-06

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 48.99  E-value: 1.80e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   31 YLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIG--VSSIGYPMSAASDLHgsWKFGHAGCQIYAGLnIFF 108
Cdd:cd15190  17 YMLVFVLGLSGNGLVLWTVFRSKRKRRRSADTFIANLALADLTfvVTLPLWAVYTALGYH--WPFGSFLCKLSSYL-VFV 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  109 GM-VSIGLLTVVAMDRYLTISCPDVGRRMTTNTYlsmilGAWINGLFWAL-----MPIIGWASYAPD--PTGATCTINWR 180
Cdd:cd15190  94 NMyASVFCLTGLSFDRYLAIVRSLASAKLRSRTS-----GIVALGVIWLLaallaLPALILRTTSDLegTNKVICDMDYS 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  181 ---NNDTSF-------VSYTMMvivvNFIVPLTVMFYCYYHVSRSLrlyaASDCTAHLHRDWADQADVTKMSVIMILMFL 250
Cdd:cd15190 169 gvvSNESEWawiaglgLSSTVL----GFLLPFLIMLTCYFFIGRTV----ARHFSKLRRKEDKKKRRLLKIIITLVVTFA 240

                ....*....
gi 3024316  251 LAWSPYSIV 259
Cdd:cd15190 241 LCWLPFHLV 249
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
27-150 2.04e-06

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 48.60  E-value: 2.04e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNI 106
Cdd:cd15317   2 IIYIVLVLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPFSMIRTVETCWYFGDLFCKFHTGLDL 81
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 3024316  107 FFGMVSIGLLTVVAMDRYLTISCPDV-GRRMTTNTYLSMILGAWI 150
Cdd:cd15317  82 LLCTTSIFHLCFIAIDRYYAVCDPLRyPSKITVQVAWRFIAIGWL 126
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
27-303 2.23e-06

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 48.61  E-value: 2.23e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSiLSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMsaasDLHGSWK-----FGHAGCQIY 101
Cdd:cd15358   3 VCVTYLLIFVVGA-VGNGLTCIVILRHKVMRTPTNYYLFSLAVSDLLVLLLGMPL----ELYEMWSnypflLGAGGCYFK 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  102 AglnIFFGMV---SIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILGA-W------------INGLFWALMPIIGwas 165
Cdd:cd15358  78 T---LLFETVcfaSILNVTALSVERYIAVVHPLKAKYVVTRTHAKRVIGAvWvvsilcsipntsLHGIFQLTVPCRG--- 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  166 yaPDPTGATCTI---NWrnndtsfvSYTMMVIVVN---FIVPLTVMFYCYYHVSRSLR-----------LYAASDCTAHL 228
Cdd:cd15358 152 --PVPDSATCMLvkpRW--------MYNLIIQITTllfFFLPMGTISVLYLLIGLQLKrekmllvleakGSKAGDSYQHR 221
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  229 HRDWAD--QADVTKMSVIMILMFLLAWSPYSIVCLWACFGNPKKIPPSMA-----IIAPLFAKSSTFYNPCIYVAAHKKF 301
Cdd:cd15358 222 RIQQEKrrRRQVTKMLFVLVVVFGICWAPFHTDRLMWSFISQWTGELHLAfqyvhIISGVFFYLSSAANPVLYNLMSTRF 301

                ..
gi 3024316  302 RK 303
Cdd:cd15358 302 RE 303
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
88-266 2.37e-06

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 48.15  E-value: 2.37e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   88 HGSWKFGHAGCQIYAglnIFFGM---VSIGLLTVVAMDRYLTISCPDVGRRMTTntylsMILGAWINGLFWALMPIIGWA 164
Cdd:cd15160  63 HHNWTFGPLSCKVVG---FFFYTniyASIGFLCCIAVDRYLAVVHPLRFRGLRT-----RRFALKVSASIWVLELGTHSV 134
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  165 syapdPTGATCTINWRNN----------DTSFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRlyaASDCTAHlhrdwAD 234
Cdd:cd15160 135 -----FLGHDELFRDEPNhtlcyekypmEGWQASYNYARFLVGFLIPLSLILFFYRRVLRAVR---QSPSLER-----EE 201
                       170       180       190
                ....*....|....*....|....*....|..
gi 3024316  235 QADVTKMSVIMILMFLLAWSPYSIVCLWACFG 266
Cdd:cd15160 202 KRKIIGLLLSIVVIFLLCFLPYHVVLLVRSVI 233
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
43-303 2.61e-06

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 48.28  E-value: 2.61e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   43 NVVVLGIFIKYKEL-RTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLnIFFGM-VSIGLLTVVA 120
Cdd:cd15097  18 NSLVLAVLLRSGQSgHNTTNLFILNLSVADLCFILFCVPFQATIYSLEGWVFGSFLCKAVHFF-IYLTMyASSFTLAAVS 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  121 MDRYLTISCPDVGRRMTT--NTYLSMILGAWINGLFWAlmPIIGWASYAPDPTGATCTINWRNNDTSFVSytMMVIVVNF 198
Cdd:cd15097  97 VDRYLAIRYPLRSRELRTprNAVAAIALIWGLSLLFAG--PYLSYYDLIDYANSTVCMPGWEEARRKAMD--TCTFAFGY 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  199 IVPLTVMFYCYyhvSRSLR-LYAASDCTAHLHRDWADQADVTKMSVIMILMFLLAWSPYSIVCLWACFGNPKKIPPSMA- 276
Cdd:cd15097 173 LIPVLVVSLSY---TRTIKyLWTAVDPLEAMSESKRAKRKVTKMIIIVTALFCLCWLPHHVVILCYLYGDFPFNQATYAf 249
                       250       260
                ....*....|....*....|....*...
gi 3024316  277 -IIAPLFAKSSTFYNPCIYVAAHKKFRK 303
Cdd:cd15097 250 rLLSHCMAYANSCLNPIVYALVSKHFRK 277
7tmA_CB1 cd15340
cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G ...
27-304 2.89e-06

cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320462 [Multi-domain]  Cd Length: 292  Bit Score: 47.98  E-value: 2.89e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSILSNVVVLGIFIKYKELRT-PTNAVIINLAFTDIgVSSIGYPMSAAsDLHGSWKFGHAGCQIY--AG 103
Cdd:cd15340   2 AIAVLSLTLGTFTVLENLLVLCVILHSRSLRCrPSYHFIGSLAVADL-LGSVIFVYSFL-DFHVFHRKDSPNVFLFklGG 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  104 LNIFFgMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILGA-WINGLFWALMPIIGWASyapDPTGATCTINWRNN 182
Cdd:cd15340  80 VTASF-TASVGSLFLTAIDRYISIHRPLAYKRIVTRTKAVIAFCVmWTIAIVIAVLPLLGWNC---KKLNSVCSDIFPLI 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  183 DTSFVSY--TMMVIVVNFIV--PLTVMFYCYYHVSR--------SLRLYAASDCTAHLHRDWADQADV--TKMSVIMILM 248
Cdd:cd15340 156 DETYLMFwiGVTSVLLLFIVyaYMYILWKAHHHAVRmlqrgtqkSIIVYTSEDGKVQTTRPDQTRMDIrlAKTLVLILVV 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 3024316  249 FLLAWSPYSIVCLWACFGNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd15340 236 LIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHA 291
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
37-161 3.06e-06

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 47.86  E-value: 3.06e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   37 ITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGC--QIYagLNIFFGMVSIG 114
Cdd:cd13954  12 LLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCltQLY--FFFSLGGTECF 89
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 3024316  115 LLTVVAMDRYLTISCP-DVGRRMTTNTYLSMILGAWINGLFWALMPII 161
Cdd:cd13954  90 LLAVMAYDRYVAICHPlHYPTIMNKRVCILLAAGSWLIGFLNSLIHTV 137
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
28-310 3.30e-06

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 48.47  E-value: 3.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316    28 IAAYLIVAGITSILSNVVVLGIFIkYKELRTPTNAVIINLAFTDIgVSSIGYPMSAASDLHgSWKFGHAGCQIYAgLNIF 107
Cdd:PHA02638 101 IKIFYIIIFILGLFGNAAIIMILF-CKKIKTITDIYIFNLAISDL-IFVIDFPFIIYNEFD-QWIFGDFMCKVIS-ASYY 176
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   108 FGMVS-IGLLTVVAMDRYLTISCP-DVGRRMTTNTYLSMILGAWINGLFWALMPIIGWAS----YAPDPTGAT-----CT 176
Cdd:PHA02638 177 IGFFSnMFLITLMSIDRYFAILYPiSFQKYRTFNIGIILCIISWILSLIITSPAYFIFEAsniiFSAQDSNETisnyqCT 256
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   177 INWRNNDTSFVSYTMM----VIVVNFIVPLTVMFYCYYHVSRSLRLYAASDCTAHLhrdwadqadvtKMSVIMILMFLLA 252
Cdd:PHA02638 257 LIEDNEKNNISFLGRIlqfeINILGMFIPIIIFAFCYIKIILKLKQLKKSKKTKSI-----------IIVSIIIICSLIC 325
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 3024316   253 WSPYSIVCLWACFGNPKKIPPSMA-------------IIAPLFAKSSTFYNPCIYVAAHKKFRKAMLAMFK 310
Cdd:PHA02638 326 WIPLNIVILFATMYSFKGFNSIISehicgfiklgyamMLAEAISLTHCCINPLIYTLIGENFRMHLLMIFR 396
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
32-305 3.48e-06

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 47.87  E-value: 3.48e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   32 LIVAGITSILSNVVVLGifiKYKELRTPTNAVIINLAFTDIgVSSIGYPMsaasDLHG-----SWKFGHAGCQIYAGLNI 106
Cdd:cd15928  10 LMLVGASGNLLTVLVIG---RSRDMRTTTNLYLSSLAVSDL-LIFLVLPL----DLYRlwryrPWRFGDLLCRLMYFFSE 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILG-AWINGLFWA----LMPIIGWASYAPDPTGATCTINwrN 181
Cdd:cd15928  82 TCTYASILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAvIWAVAIVSAgpalVLVGVEHIQGQQTPRGFECTVV--N 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  182 NDTSFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAASDCTAHLHRDWADQADVTKMSVIMILMFLLAWSPYSI--V 259
Cdd:cd15928 160 VSSGLLSVMLWVSTSFFFVPMVCLSLLYGLIGRALWDRRQRSRTAGASRRDNNHRQTVRMLAVIVLAFVLCWLPFHVgrV 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 3024316  260 CLWACFGNPKK---IPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKAM 305
Cdd:cd15928 240 IFNHSRASTKHlhyVSQYFNLVSFVLFYLSAAINPILYNLMSKRYRYAV 288
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
40-303 6.42e-06

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 47.14  E-value: 6.42e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   40 ILSNVVVLGIFIKYKELRTPTNAVIINLAFTDI-GVSSIGYpmsAASDLHGSWKFGHAGCQIYAGLNI--FFGmvSIGLL 116
Cdd:cd15186  15 LVGNLLVVLALTNSGKSKSITDIYLLNLALSDLlFVATLPF---WTHYLINEWGLHNAMCKLTTAFFFigFFG--GIFFI 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  117 TVVAMDRYLTIS-CPDVGRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTGATCTI---NW---RNNDTSFVSy 189
Cdd:cd15186  90 TVISIDRYLAIVlAANSMNNRTVQHGVTISLGVWAAAILVAVPQFMFTKMKENECLGDYPEVlqeIWpvlRNVELNFLG- 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  190 tmmvivvnFIVPLTVMFYCYYHVSRSLrlyaaSDCTAHlhrdwaDQADVTKMSVIMILMFLLAWSPYSIVCLWACFgNPK 269
Cdd:cd15186 169 --------FLLPLLIMSYCYFRIIQTL-----FSCKNH------KKARAIKLILLVVIVFFLFWTPYNVMIFLETL-KLY 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 3024316  270 KIPPSMAIIAPL---------FAKSSTFYNPCIYVAAHKKFRK 303
Cdd:cd15186 229 DFFPSCDMKKDLrlalsvtetIAFSHCCLNPLIYAFAGEKFRR 271
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
33-304 7.32e-06

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 46.85  E-value: 7.32e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   33 IVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTD---------IGVSSIGYPMSAASdlHGSWKFGHAGCQIYAG 103
Cdd:cd14980   9 IIGILALIGNILVIIWHISSKKKKKKVPKLLIINLAIADflmgiylliIAIADQYYRGRYAQ--YSEEWLRSPPCLLACF 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  104 LNIFFGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTGAT----CTINW 179
Cdd:cd14980  87 LVSLSSLMSVLMMLLITLDRYICIVYPFSNKRLSYKSAKIILILGWLFSIIFAAIPILYSINQPGDNRLYGyssiCMPSN 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  180 RNNdTSFVSYTMMVIVVNFIVPLTVMFyCYYHVSRSLRlyaASDCTAHLHRDWADQADVTKMSVImILMFLLAWSPYSIV 259
Cdd:cd14980 167 VSN-PYYRGWLIAYLLLTFIAWIIICI-LYILIFISVR---KSRKSARRSSSKRDKRIAIRLALI-LITDLICWLPYYIV 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 3024316  260 CLWACFGNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKA 304
Cdd:cd14980 241 IFSGLLTSTEIDIHVLQFIAILALPLNSAINPYLYTLTTPTFKRD 285
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
29-219 9.69e-06

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 46.33  E-value: 9.69e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   29 AAYLIVAgITSILSNVVVLGIFikYKELRT-PTNAVIINLAFTDIgVSSIGYPMSAASDLHGS-WKFGHAGCQIYAgLNI 106
Cdd:cd15371   5 AVYIIVV-VLGVPSNAIILWML--FFRLRSvCTAIFYANLAISDL-LFCITLPFKIVYHLNGNnWVFGETMCRIIT-ITF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGM-VSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILGAWINGLFWALMP--IIGWASYAPDPTGATC----TINW 179
Cdd:cd15371  80 YGNMyCSILLLTCISINRYLAIVHPFIYRSLPKKTYAVLICALVWTIVFLYMLPffILKQTYYLKELNITTChdvlPECE 159
                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 3024316  180 RNNDTSFVSYTMMvIVVNFIVPLTVMFYCYYHVSRSLRLY 219
Cdd:cd15371 160 QNSNFQFYYFISM-AVFGFLIPLVITIFCYISIIRTLNAY 198
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
32-161 1.16e-05

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 46.32  E-value: 1.16e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   32 LIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFGMV 111
Cdd:cd15912   7 LLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYFFLGTT 86
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 3024316  112 SIGLLTVVAMDRYLTISCPdvgRR----MTTNTYLSMILGAWINGLFWALMPII 161
Cdd:cd15912  87 EFFLLAVMSFDRYVAICNP---LHyptiMNSRVCLQLVLGSWVGGFLLILPPTI 137
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
39-303 1.23e-05

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 46.31  E-value: 1.23e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   39 SILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIgVSSIGYPMSAASDLHGS-WKFGHAGCQIYAGLNIFFGMVSIGLLT 117
Cdd:cd15968  14 GLPLNSVVLTRCCRHTKAWTRTAIYMVNLALADL-LYALSLPLLIYNYAMRDrWLFGDFMCRLVRFLFYFNLYGSILFLT 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  118 VVAMDRYLTISCPdvGRRMTTNTYLSMILG---AWInGLFWALMPIIGWASYAPDPTGATC-TINWRNNDTSFVSYTMMV 193
Cdd:cd15968  93 CISVHRYLGICHP--MRPWHKETRRAAWLTcvlVWI-LVFAQTLPILIFARTGIIRNRTVCyDLAPPALFPHYVPYGMAL 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  194 IVVNFIVPLTVMFYCYYHVSRSLrlyAASDCTAHLHRDwADQADVTKMSVIMILMFLLAWSPYSI-----VCLWACFGNP 268
Cdd:cd15968 170 TVSGFLLPFSIILWCYCLVVRTL---CRTLGPAEPPAQ-ARRRKSIRTIVTVTLLFALCFLPFHItrtiyLAVRVTPGVP 245
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 3024316  269 KKIPPSMAI---IAPLFAKSSTFYNPCIYVAAHKKFRK 303
Cdd:cd15968 246 CHVLEAVAAcykITRPLASANSVLNPLLYFLTKKKFGR 283
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
34-303 1.28e-05

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 46.29  E-value: 1.28e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   34 VAGITSILSNVVVlgIFIKYKELRTPTNAV-IINLAFTDIgVSSIGYPMS---AASDLHgsWKFGHAGCQIYAGLNIFFG 109
Cdd:cd15116   9 VVFVLGVLGNGLV--IFITGFKMKKTVNTVwFLNLAVADF-LFTFFLPFSiayTAMDFH--WPFGRFMCKLNSFLLFLNM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  110 MVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMI-LGAWINGLFWA--------------LMPIIGWASYAPDPTGAT 174
Cdd:cd15116  84 FTSVFLLTVISIDRCISVVFPVWSQNHRSVRLASLVsLAVWVVAFFLSspsfifrdtapsqnNNKIICFNNFSLSGDNSS 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  175 CTINWRNNdTSFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRlyaasdctahlHRDWADQADVTKMSVIMILMFLLAWS 254
Cdd:cd15116 164 PEVNQLRN-MRHQVMTITRFLLGFLIPFTIIICCYAAIVLKLK-----------RNRLAKSSKPFKIIAAVIVTFFLCWA 231
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 3024316  255 PYSIVCLWACFGNPkkIPPSMAIIAPLFAKSSTFYNPCI----YVAAHKKFRK 303
Cdd:cd15116 232 PYHILNLLEMEATR--SPASVFKIGLPITSSLAFINSCLnpilYVFMGQDFKK 282
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
22-296 2.96e-05

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 45.17  E-value: 2.96e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   22 RTEHSVIAAYLIVAgitsILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIY 101
Cdd:cd15386   1 KVEIGVLAAILVVA----TAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVALFQVLPQLIWEITYRFQGPDLLCRAV 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  102 AGLNIFFGMVSIGLLTVVAMDRYLTISCP-DVGRRMTTNTYLsMILGAWINGLFWALMPIIGWASYAPDPTG------AT 174
Cdd:cd15386  77 KYLQVLSMFASTYMLIMMTVDRYIAVCHPlRTLQQPSRQAYL-MIGATWLLSCILSLPQVFIFSLREVDQGSgvldcwAD 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  175 CTINWrnNDTSFVSYTMMVIvvnFIVPLTVMFYCY----YHVSRSLRL-YAASDCTAHLHRDWADQADVT---------- 239
Cdd:cd15386 156 FGFPW--GAKAYITWTTLSI---FVLPVAILIVCYslicYEICKNLKGkTQTSRSEGGGWRTQGMPSRVSsvrtisraki 230
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 3024316  240 ---KMSVIMILMFLLAWSPYSIVCLWACF--GNPKKIPPSMAI-IAPLFAKSSTFYNPCIYVA 296
Cdd:cd15386 231 rtvKMTFVIVLAYIACWAPFFSVQMWSVWdeNAPDEDSSDFAFtITMLLASLSSCCNPWIYMF 293
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
30-296 3.67e-05

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 44.76  E-value: 3.67e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   30 AYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFG 109
Cdd:cd15388   5 AVLAIIFACALLSNSLVLLVLWRRRKQLARMHVFMLHLCIADLVVAFFQVLPQLVWDITDRFRGPDVLCRLVKYLQVVGM 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  110 MVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILGAWINGLFWALMPII-------------GWASYApDPTGATCT 176
Cdd:cd15388  85 FASSYMIVAMTFDRHQAICRPMVTFQKGRARWNGPVCVAWAISLILSLPQVFifskvevapgvyeCWACFI-EPWGLKAY 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  177 INWrnndtsfvsYTMMVivvnFIVPLTVMFYCYYHVSRSL---------RLYAASDCTAHLHRDWADQADVT-------K 240
Cdd:cd15388 164 VTW---------ITLVV----FVLPTLIITVCQVLIFKEIhiniylksqIIVAVVKKKQLLSSRASSVAEVSkamiktvK 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 3024316  241 MSVIMILMFLLAWSPYSIVCLWACFgNPKKIPPSMA-IIAPLFAKSSTFYNPCIYVA 296
Cdd:cd15388 231 MTLVIVLVYVLCWAPFFLVQLWSVW-DPKAPTEGATfTILMLLASLNSCTNPWIYMA 286
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
58-258 3.72e-05

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 44.68  E-value: 3.72e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   58 TPTNAVIINLAFTDIgVSSIGYPMSAASDLHGS-WKFGHAGCQI---YAGLNIFfgmVSIGLLTVVAMDRYLTISCP--D 131
Cdd:cd15967  33 GNINVFVLNLGLADL-LYLLTLPFLVVYYLKGRkWIFGQVFCKItrfCFNLNLY---GSIGFLTCISVYRYLAIVHPmrV 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  132 VGRRMTTNTylsmilgAWINGLFWAL-----MPIIGWASYAPDPTGATCTINwRNNDTSFVSYTMMVIVVNFIVPLTVMF 206
Cdd:cd15967 109 MGRITTTHS-------VVISALVWLLvviqsLPDLFFSKTNSNGTKCFDTTF-NDYLESYLTYSLGWTVTGFVIPLLIIL 180
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 3024316  207 YCYYHVSRSLRLYAASDCTAhlhrdwadQADVTKMSVIMILMFLLAWSPYSI 258
Cdd:cd15967 181 GCYGHVVVVLCRNNNVDKGL--------KQRCLKLVIILIVLFSVCYIPYHV 224
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
57-305 4.12e-05

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 44.50  E-value: 4.12e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   57 RTPTNAVIINLAFTDIGVSsIGYPMSAASD-LHGSWKFGHAGCQIYAGLNIFFGMVSIGLLTVVAMDRYLTI-SCPDVGR 134
Cdd:cd15926  33 KSSINLFVTSLAVTDFQFV-LTLPFWAVENaLDFTWLFGKAMCKIVSYVTAMNMYASVFFLTAMSVARYHSVaSALKSKR 111
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  135 RMTTNTYLSMILGAWINGLFwALMPIIGWASYAPDPTGATCTINW--RNNDTSFVS--YTMMVIVVNFIVPLTVMFYCYY 210
Cdd:cd15926 112 RRGCCSAKWLCVLIWVLAIL-ASLPNAIFSTTATVSNEELCLVKFpdNRGNAQFWLglYHAQKVLLGFLIPLGIISLCYL 190
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  211 HVsrsLRLYAASDCTAHLHRDwadQADVTKMSVIMILMFLLAWSPYSIVCLWACFGNPKKIPPS------MAIIAPL--- 281
Cdd:cd15926 191 LL---VRFITDKNITGSSTKR---RSKVTKSVTIVVLSFFLCWLPNQALTTWGILIKLNVVHFSyeyfttQVYIFPItvc 264
                       250       260
                ....*....|....*....|....
gi 3024316  282 FAKSSTFYNPCIYVAAHKKFRKAM 305
Cdd:cd15926 265 LAHSNSCLNPILYCLMRREFRKAL 288
7tmA_LHCGR cd15359
luteinizing hormone-choriogonadotropin receptor, member of the class A family of ...
37-303 4.58e-05

luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. LHCGR is expressed predominantly in the ovary and testis, and plays an essential role in sexual development and reproductive processes. LHCGR couples primarily to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320481 [Multi-domain]  Cd Length: 275  Bit Score: 44.47  E-value: 4.58e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   37 ITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHA-------GCQIYAGLNIFFG 109
Cdd:cd15359  12 ILAIAGNLIVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKSQYYNHAidwqtgsGCSTAGFFTVFAS 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  110 MVSIGLLTVVAMDRYLTIS-CPDVGRRMTTNTYLSMILGAWINGLFWALMPIIGWASYapdptgATCTINWRNNDTSFVS 188
Cdd:cd15359  92 ELSVYTLTVITLERWHTITyAMQLDRKLRLRHAILIMLGGWVFSLLIAVLPLVGVSNY------MKVSICLPMDIETLLS 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  189 --YTMMVIVVNfIVPLTVMFYCY---YHVSRSLRLYAASDCTahlhrdwadqaDVTKMSVIMILMFLLAWSPYSIVCLWA 263
Cdd:cd15359 166 qaYILLILVLN-VIAFLVICACYikiYLAVQNPELVAKNKDT-----------KIAKRMAILIFTDFTCMAPISFFAISA 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 3024316  264 CFGNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRK 303
Cdd:cd15359 234 AFKVPLITVTNSKILLVLFYPINSCANPFLYAIFTKAFRR 273
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
26-258 4.77e-05

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 44.49  E-value: 4.77e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   26 SVIAAYLIVAGITSilsNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLN 105
Cdd:cd15131   4 TVTCVLLFVVGVTG---NLMTMLVVSKYRDMRTTTNLYLSSMAFSDLLIFLCMPLDLYRLWQYRPWNFGDLLCKLFQFVS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  106 IFFGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSM-ILGAWINGLFWA--LMPIIGWA-SYAPDPTGAT-CTINWR 180
Cdd:cd15131  81 ESCTYSTILNITALSVERYFAICFPLRAKVVVTKRRVKLvILVLWAVSFLSAgpIFVLVGVEhENGTNPIDTNeCKATEY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  181 NNDTSFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSL---RLYAASDCTAhlHRDWADQADVtKMSVIMILMFLLAWSPYS 257
Cdd:cd15131 161 AVRSGLLTIMVWVSSVFFFLPVFCLTVLYSLIGRKLwrrRRENIGPNAS--HRDKNNRQTV-KMLAVVVFAFVLCWLPFH 237

                .
gi 3024316  258 I 258
Cdd:cd15131 238 V 238
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
37-209 5.60e-05

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 44.04  E-value: 5.60e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   37 ITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIgVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFGMVSIGLL 116
Cdd:cd15166  12 IIGLFVNITALWVFSCTTKKRTTVTVYMMNVALVDL-IFILSLPFRMVYYAKDEWPFGDYFCRILGALTVFYPSIALWLL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  117 TVVAMDRYLTISCPDVGRRM-TTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTGATCTinwRNNDTSFVSYTMMV-- 193
Cdd:cd15166  91 AFISADRYMAIVQPKHAKELkNTPKAVLACVGVWIMTLASTFPLLFLYEDPDKASNFTTCL---KMLDIIHLKEVNVLnf 167
                       170
                ....*....|....*...
gi 3024316  194 --IVVNFIVPLTVMFYCY 209
Cdd:cd15166 168 trLIFFFLIPLFIMIGCY 185
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
43-303 5.92e-05

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 44.09  E-value: 5.92e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   43 NVVVLGIFIKYKELRTPTNAV---IINLAFTDIGVSSIGYPMSAASDL--HGSWKFGHAGCQIYAGLNIFFGMVSIGLLT 117
Cdd:cd15356  18 NALTIHLVLKKRSLRGLQGTVhyhLVSLALSDLLILLISVPIELYNFVwfHYPWVFGDLVCRGYYFVRDICSYATVLNIA 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  118 VVAMDRYLTISCPDVGRRMTTNTYLSMILGA-WINGLFWAL-MPIIGWASY-------APDPTGATCTINWRNndTSFVS 188
Cdd:cd15356  98 SLSAERYLAICQPLRAKRLLSKRRTKWLLALiWASSLGFALpMAFIMGQKYeletadgEPEPSSRVCTVLVSR--ATLKV 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  189 YTMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAAsdctahlhrdwadQADVTKMSVIMIlMFLLAWSPYSIVCLWACFgnp 268
Cdd:cd15356 176 FIQVNAFVSFVLPLALIAFLNGVTVSHLRIQSL-------------QHSVQVLRAIVI-AYVICWLPYHARRLMFCY--- 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 3024316  269 kkiPPSMAIIAPLFAKSSTFY-------------NPCIYVAAHKKFRK 303
Cdd:cd15356 239 ---VPDDAWTDSLYNFYHYFYmltntlfyvssavNPLLYNVVSSSFRK 283
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
28-258 6.35e-05

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 44.02  E-value: 6.35e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   28 IAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIgVSSIGYPMsaasDLHGSWK-----FGHAGCQIYA 102
Cdd:cd15132   3 VTIVCLILFVVGVTGNTMTVLIIRRYKDMRTTTNLYLSSMAVSDL-LILLCLPF----DLYRLWKsrpwiFGEFLCRLYH 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  103 GLNIFFGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILGA-WINGL-----FWALMPIIGWASYAPDPTGATCT 176
Cdd:cd15132  78 YISEGCTYATILHITALSIERYLAICFPLRAKVLVTRRRVKCVIAAlWAFALlsagpFLFLVGVEQDNNIHPDDFSRECK 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  177 INWRNNDTSFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSL---RLYAASDCTAHLHRdwaDQADVTKMSVIMILMFLLAW 253
Cdd:cd15132 158 HTPYAVSSGLLGIMIWVTTTYFFLPMLCLSFLYGFIGRKLwksKNDLRGPNAAARER---SHRQTVRILAVVVLAFIICW 234

                ....*
gi 3024316  254 SPYSI 258
Cdd:cd15132 235 LPFHI 239
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
37-258 7.29e-05

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 43.69  E-value: 7.29e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   37 ITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIgVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFGMVSIGLL 116
Cdd:cd15156  12 VLGLIANCVAIYIFMCTLKVRNETTTYMINLAISDL-LFVFTLPFRIFYFVQRNWPFGDLLCKISVTLFYTNMYGSILFL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  117 TVVAMDRYLTISCPDVGRRMTTNTYLSMI-LGAWINGLFWALMPIIGWASYAPDPTGA-TCTINWRNND-TSFVSYTMMV 193
Cdd:cd15156  91 TCISVDRFLAIVYPFRSKTLRTKRNAKIVcAAVWLTVLAGSLPASFFQSTNNQLNNNSeTCFENFSSKTwKTYLSKIVIF 170
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 3024316  194 I-VVNFIVPLTVMFYCYYHVSRSLRLyaasdcTAHLHRDWADQADVTKMSVIMILMFLLAWSPYSI 258
Cdd:cd15156 171 IeIVGFFIPLILNVTCSTMVLKTLRR------PNTLSRSKLNKKKVLKMIFVHLFIFCFCFIPYNV 230
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
37-153 1.02e-04

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 43.09  E-value: 1.02e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   37 ITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFGMVSIGLL 116
Cdd:cd15936  12 LTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFHFTGGAEVFLL 91
                        90       100       110
                ....*....|....*....|....*....|....*...
gi 3024316  117 TVVAMDRYLTISCP-DVGRRMTTNTYLSMILGAWINGL 153
Cdd:cd15936  92 SVMAYDRYIAIHKPlHYLTIMNQGVCTGLVAGSWLGGF 129
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
31-152 1.15e-04

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 43.19  E-value: 1.15e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   31 YLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFGM 110
Cdd:cd15942   6 FFLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHFLGC 85
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 3024316  111 VSIGLLTVVAMDRYLTISCP-DVGRRMTTNTYLSMILGAWING 152
Cdd:cd15942  86 AECFLYTVMAYDRFLAICKPlHYSTIMNHRACLCLSLGTWLGG 128
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
27-267 1.75e-04

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 42.89  E-value: 1.75e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAgITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNI 106
Cdd:cd15981   3 FILAYLFIF-LLCMVGNGLVCFIVLKNRQMRTVTNMFILNLAVSDLLVGIFCMPTTLVDNLITGWPFDNAMCKMSGLVQG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  107 FFGMVSIGLLTVVAMDRYLTISCPdVGRRMTTNTYLSMILgawingLFWALMPIIGWAS-----------------YAPD 169
Cdd:cd15981  82 MSVSASVFTLVAIAVERFRCIVHP-FRQKLTLRKAIVTIV------IIWVLALIIMCPSavtltvtreehhfmvddYNNS 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  170 PTGATCTINWRNNDTSFVsYTMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAASDCTAHLH-----RDWADQADVTKMSVI 244
Cdd:cd15981 155 YPLYSCWEAWPDTEMRKI-YTTVLFSHIYLAPLTLIVIMYARIAFKLFKSSAPIRGSQGEeeegrRVSKRKIKVINMLII 233
                       250       260
                ....*....|....*....|...
gi 3024316  245 MILMFLLAWSPYSIVCLWACFGN 267
Cdd:cd15981 234 VALFFTLSWLPLWTLMLLTDYGH 256
7tmA_PGE2_EP2 cd15139
prostaglandin E2 receptor EP2 subtype, member of the class A family of seven-transmembrane G ...
27-258 1.84e-04

prostaglandin E2 receptor EP2 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP2, also called prostanoid EP2 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Stimulation of the EP2 receptor by PGE2 causes cAMP accumulation through G(s) protein activation, which subsequently produces smooth muscle relaxation and mediates the systemic vasodepressor response to PGE2. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320267 [Multi-domain]  Cd Length: 299  Bit Score: 42.45  E-value: 1.84e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGItsiLSNVVVLGI--FIKYKELRTPT---NAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFG----HAG 97
Cdd:cd15139   5 AISALMFSAGV---LGNVLALVLleRRRRKEVGRRQslfHVLVTSLVITDLLGTCLISPVVLASYSRNTTLVGmspnRLV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   98 CQIYAGLNIFFGMVSIGLLTVVAMDRYLTISCPDV-GRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTGATCT 176
Cdd:cd15139  82 CGYFGFAMTFFSLATMLILLAMALERCLSIGHPYFyERYVSKRCGYVTIPLIYLLCALFCLFPFLGFGKYVQYCPGTWCF 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  177 INWRNNDTSFVSY-----TMMVIVVnfIVPLTVMFYCYYHVSRSLRLYAASDCTAHL-------HRDWADQADVTKMSVI 244
Cdd:cd15139 162 IDMNPEASEHRAYanlyaTLLLLLI--VAVVLCNASVIYHLVRMYRRRKRNRSSVGGrarshrrRFSMAEEVEHLILLVF 239
                       250
                ....*....|....
gi 3024316  245 MILMFLLAWSPYSI 258
Cdd:cd15139 240 MTIIFVICSLPLTI 253
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
26-217 2.07e-04

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 42.35  E-value: 2.07e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   26 SVIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSsIGYPMSAASDLHGS-WKFGHAGCQIyagl 104
Cdd:cd15201   1 YVLPPVLILEFVLGLLGNGLALWIFCFHLKSWKSSTVYLFNLAVADFLLI-ICLPFRTDYYLRGKhWKFGDIPCRI---- 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  105 nIFFGMV-----SIGLLTVVAMDRYLTISCPdvgrRMTTNTyLSMILGAWINGLFWALmpIIGWASYAPDPTGATCtinw 179
Cdd:cd15201  76 -VLFMLAmnragSIFFLTAVAVDRYFRVVHP----HHRINS-ISVRKAAIIACGLWLL--TIAMTVYLLTKKHLFP---- 143
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 3024316  180 RNNDTSFVSYTM------------MVIVVNFIVPLTVMFYCYYHVSRSLR 217
Cdd:cd15201 144 RGNATQCESFNIctgtdsssnwheAMFLLEFFLPLAIILYCSVRIIWQLR 193
7tmA_OR5P-like cd15416
olfactory receptor subfamily 5P and related proteins, member of the class A family of ...
30-158 2.15e-04

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320538 [Multi-domain]  Cd Length: 279  Bit Score: 42.35  E-value: 2.15e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   30 AYLIVAGITsILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFG 109
Cdd:cd15416   6 LFLVIYSVT-LLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAATFG 84
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 3024316  110 MVSIGLLTVVAMDRYLTISCPDV-GRRMTTNTYLSMILGAWINGLFWALM 158
Cdd:cd15416  85 TVECFLLAAMAYDRYVAICNPLLySTIMSQKVCVLLVAASYLGGCLNALV 134
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
42-216 2.98e-04

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 42.04  E-value: 2.98e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   42 SNVVVLGIFIkYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGlnIFFGMV--SIGLLTVV 119
Cdd:cd15372  17 ANGLALWVLA-TQVKRLPSTIFLINLAVADLLLILVLPFKISYHFLGNNWPFGEGLCRVVTA--FFYGNMycSVLLLMCI 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  120 AMDRYLTISCPDVGRRM-TTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTGATC---TINWRNNDTSFVSYTMMVIV 195
Cdd:cd15372  94 SLDRYLAVVHPFFARTLrSRRFALCMCTAIWLIAAALTLPLTLQRQSYPLERLNITLchdVLPLDEQDTYLFYYFACLAV 173
                       170       180
                ....*....|....*....|.
gi 3024316  196 VNFIVPLTVMFYCYYHVSRSL 216
Cdd:cd15372 174 LGFLLPLVVILFCYGSVLHTL 194
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
27-292 3.23e-04

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 41.69  E-value: 3.23e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYLIVAGITSILSNVVVLGIfIKYKELRTPTNAVIINLAFTDIGVSSIgYPMSAASDLHGS-WKFGHAGCQIYAGLn 105
Cdd:cd15120   2 LIAVALFVTFLVGLVVNGLYLWV-LGFKMRRTVNTLWFLHLILSNLIFTLI-LPFMAVHVLMDNhWAFGTVLCKVLNST- 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  106 IFFGM-VSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLS-MILGAWINGLFWALMPIIGWASYAPDPTGATCTINW---R 180
Cdd:cd15120  79 LSVGMfTSVFLLTAISLDRYLLTLHPVWSRQHRTNRWASaIVLGVWISAILLSIPYLAFRETRLDEKGKTICQNNYalsT 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  181 NNDTSFVSYTMMVIVV---------NFIVPLTVMFYCYYHVSRSLRlyaasdctahlHRDWADQADVTKMSVIMILMFLL 251
Cdd:cd15120 159 NWESAEVQASRQWIHVamfvfrfllGFLLPFLIITFCYVRMALKMK-----------ERGLARSSKPFKVMFTAVVSFFV 227
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 3024316  252 AWSPYSivcLWACFGNPKKIPPSMAIIAPLFAKSSTFYNPC 292
Cdd:cd15120 228 CWLPYH---LHSGLVLTRGRPPSLTDITLLLTVGTTCFNTC 265
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
31-162 3.89e-04

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 41.44  E-value: 3.89e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   31 YLIVAGITsILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGC--QIYAGLniFF 108
Cdd:cd15431   7 LLIVYLVT-LLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRClaQMYISL--FL 83
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 3024316  109 GMVSIGLLTVVAMDRYLTISCPdvgRR----MTTNTYLSMILGAWINGLFWALMPIIG 162
Cdd:cd15431  84 GITECLLLAVMAYDRFVAICNP---LRytliMSWRVCIQLAAGSWVSAFLLTVIPVLT 138
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
37-258 4.24e-04

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 41.63  E-value: 4.24e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   37 ITSILSNVVVLGIFIKYkeLRTPTNAVI--INLAFTDIgVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFGMVSIG 114
Cdd:cd15152  12 IPGLIGNVLALWVFYAY--VKETKRAVIfmINLAIADL-LQVLSLPLRIFYYLNKSWPFGKFLCMFCFYLKYVNMYASIY 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  115 LLTVVAMDRYLTISCP----DVGRRMttNTYLSmILGAWINGLFWALMPIIGwASYAPDPTGATCTINWRNNDTSfVSYT 190
Cdd:cd15152  89 FLVCISVRRCLYLIYPfrynDCKRKC--DVYIS-IAGWLVVCVGCLPFPLLR-QSQDTNPTCCFADLPLRNVGLT-TSVI 163
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  191 MMVI--VVNFIVPLTVMFYCYYHVSRSLRlyaASDCTAHlhrDWADQADVTKMSVIMILMFLLAWSPYSI 258
Cdd:cd15152 164 MLTIaeLTGFVTPLLIVLYCSWKTVMSLR---EKTPVLQ---DLGEKKKALKMILTCAVVFLICFAPYHI 227
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
56-130 4.34e-04

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 41.45  E-value: 4.34e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 3024316   56 LRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGC--QIYagLNIFFGMVSIGLLTVVAMDRYLTISCP 130
Cdd:cd15918  31 LHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCltQMY--FFLLFGDLDNFLLAVMAYDRYVAICHP 105
7tmA_PGE2_EP1 cd15144
prostaglandin E2 receptor EP1 subtype, member of the class A family of seven-transmembrane G ...
40-177 4.50e-04

prostaglandin E2 receptor EP1 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP1, also called prostanoid EP1 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. It has been shown that stimulation of the EP1 receptor by PGE2 causes smooth muscle contraction and increased intracellular Ca2+ levels; however, it is still unclear whether EP1 receptor is exclusively coupled to G(q/11), which leading to activation of phospholipase C and phosphatidylinositol hydrolysis. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320272 [Multi-domain]  Cd Length: 294  Bit Score: 41.30  E-value: 4.50e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   40 ILSNVVVLGIFIK-YKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLH-----GSWKFGHAG--CQIYAGLNIFFGMV 111
Cdd:cd15144  15 ALSNIVALVILAQsYARFRRRSKATFLLFASSLVLTDLAGHVIPGALVLRlylsgQMPAEEPRGalCQFFGACMVFFGLC 94
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 3024316  112 SIGLLTVVAMDRYLTISCP--DVGRRMTTNTYLSmILGAWINGLFWALMPIIGWASYAPDPTGATCTI 177
Cdd:cd15144  95 PLFLGCAMAVERCVGVTRPllHSSVVTTTRTKLS-LLAIWAVALAVALLPLFRFGRYKPQFPGTWCFI 161
7tmA_PGE2_EP3 cd15146
prostaglandin E2 receptor EP3 subtype, member of the class A family of seven-transmembrane G ...
108-261 5.21e-04

prostaglandin E2 receptor EP3 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP3, also called prostanoid EP3 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Stimulation of the EP3 receptor by PGE2 preferentially couples to G(i) protein. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels, which subsequently produces smooth muscle contraction. Knockout mice studies suggest that the EP3 receptor may act as a systemic vasopressor. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320274 [Multi-domain]  Cd Length: 308  Bit Score: 41.40  E-value: 5.21e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  108 FGMVSIGLLTVVAMDRYLTISCPD-VGRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTGATCTI-----NWRN 181
Cdd:cd15146  92 FGLCPLFIASAMAIERALAIRAPHwYSSHMKTRVTKAVLLGIWLAVLAFALLPIAGVGQYTLQWPGTWCFIstgdgEPGN 171
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  182 N--DTSFVSYTMMVIVVNFIVPLTVMFYCyyhVSRSLRLYAASDCTAHlhrdWADQADVTKMSVIMILMFLLA-WSPYSI 258
Cdd:cd15146 172 NffASTFASLGLFSLCVTFSCNLATIRAL---VSRCKTKAGASVSSKQ----WERITTETLIQLLGIMCVLSAcWSPLLV 244

                ...
gi 3024316  259 VCL 261
Cdd:cd15146 245 LML 247
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
21-309 5.27e-04

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 41.43  E-value: 5.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316    21 SRTEHSVIAAYLIVAgITSILSNVVVLGIFIkYKELRTPTNAVIINLAFTDIgVSSIGYPMSAASDLHgSWKFGHAGCQI 100
Cdd:PHA02834  25 SDVNYFVIVFYILLF-IFGLIGNVLVIAVLI-VKRFMFVVDVYLFNIAMSDL-MLVFSFPFIIHNDLN-EWIFGEFMCKL 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   101 YAGLNIFFGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILGAWINGLFWAlMPIIgwASYAPDPTGATCTINWR 180
Cdd:PHA02834 101 VLGVYFVGFFSNMFFVTLISIDRYILVVNATKIKNKSISLSVLLSVAAWVCSVILS-MPAM--VLYYVDNTDNLKQCIFN 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   181 NNDTSFVSYTMMVIVVNF---IVPLTVMFYCYYHVsrslrLYAASDCTAhlhrdwADQADVTKMSVIMILMFLLAWSPYS 257
Cdd:PHA02834 178 DYHENFSWSAFFNFEINIfgiVIPLIILIYCYSKI-----LYTLKNCKN------KNKTRSIKIILTVVTFTVVFWVPFN 246
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 3024316   258 IVCL-----------WACFgNPKKIPPSMAiIAPLFAKSSTFYNPCIYVAAHKKFRKAMLAMF 309
Cdd:PHA02834 247 IVLFinslqsvglidIGCY-HFKKIVYSID-IAELISFVHCCVNPIIYAFVGKNFKKVFKNMF 307
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
37-161 5.62e-04

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 41.03  E-value: 5.62e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   37 ITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDL--HGSWKFGHAGCQIYagLNIFFGMVSIG 114
Cdd:cd15226  12 VATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLreHKTISFGGCMAQIF--FLHFFGGSEMV 89
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 3024316  115 LLTVVAMDRYLTISCP-DVGRRMTTNTYLSMILGAWINGLFWALMPII 161
Cdd:cd15226  90 LLIAMAFDRYVAICKPlHYLTIMSPRMCILLVVASWIIGFIHSLSQLA 137
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
37-258 5.73e-04

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 41.18  E-value: 5.73e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   37 ITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIgVSSIGYPMSAASDLHG-SWKFGHAGCQIYAGLNIFFGMVSIGL 115
Cdd:cd15159  12 VFGLLGNTLALHVICQKRKKINSTTLYLINLAVSDI-LFTLALPGRIAYYALGfDWPFGDWLCRLTALLFYINTYAGVNF 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  116 LTVVAMDRYLTISCPDVGRRMTTNTYLSmilgaWINGLFWAL-----MPIIGWASYAPDPTGATCtINWRNNDTSF-VSY 189
Cdd:cd15159  91 MTCLSVDRYIAVVHPLRRHRLRKVKVVR-----YICVFVWVLvflqtLPLLFMPMTKEMGGRITC-MEYPNFEKIKrLPL 164
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 3024316  190 TMMV-IVVNFIVPLTVMFYCYYHVSRSLRLYAASDctahlhrDWADQADVTKMSVIMILMFLLA----WSPYSI 258
Cdd:cd15159 165 ILLGaCVIGFGVPVGIILFCYSQITLKLCRTAKEN-------PLTEKSGHHKKACNVILLVLLVfvvcFSPYHL 231
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
27-153 7.11e-04

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 40.52  E-value: 7.11e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   27 VIAAYlivagITSILSN-VVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLN 105
Cdd:cd15935   7 VLACY-----AAILLGNlLIVVTVHADPHLLQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFL 81
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 3024316  106 IFFGMVSIGLLTVVAMDRYLTISCP-DVGRRMTTNTYLSMILGAWINGL 153
Cdd:cd15935  82 HFLGGSEMLLLTLMAYDRYVAICHPlRYLAVMNRQLCIKLLAACWAGGF 130
7tmA_OR13-like cd15430
olfactory receptor family 13 and related proteins, member of the class A family of ...
37-228 8.17e-04

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320547 [Multi-domain]  Cd Length: 270  Bit Score: 40.43  E-value: 8.17e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   37 ITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFGMVSIGLL 116
Cdd:cd15430  12 LVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSLAMGSTECVLL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  117 TVVAMDRYLTISCPdvgRR----MTTNTYLSMILGAWINGLFWALMPIIgwaSYAPDPTGA-------TCTI----NWRN 181
Cdd:cd15430  92 AVMAYDRYVAICNP---LRypiiMNKRLCVQMAAGSWVTGFLNSLVETV---LAMQLPFCGnnvinhfTCEIlavlKLAC 165
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 3024316  182 NDTSFVSYTMMVIVVNFIV-PLTVMFYCY-YHVSRSLRLYAA-------SDCTAHL 228
Cdd:cd15430 166 VDISLNEIIMLVGNIIFLViPLLLICISYiFILSTILRINSAegrkkafSTCSAHL 221
7tmA_PGI2 cd15141
prostaglandin I2 receptor, member of the class A family of seven-transmembrane G ...
25-183 8.48e-04

prostaglandin I2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin I2 receptor (also called prostacyclin receptor or prostanoid IP receptor) is a class A, G protein-coupled receptor whose endogenous ligand is prostacyclin, which is the major product of cyclooxygenase metabolite of arachidonic acid that found predominantly in platelets and vascular smooth muscle cells (VSMCs). The PGI2 receptor is coupled to both G(s) and G(q) protein subtypes, resulting in increased cAMP formation, phosphoinositide turnover, and Ca2+ signaling. PGI2 receptor activation by prostacyclin induces VSMC differentiation and produces a potent vasodilation and inhibition of platelet aggregation.


Pssm-ID: 320269 [Multi-domain]  Cd Length: 301  Bit Score: 40.57  E-value: 8.48e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   25 HSVIAAYLIVAGItsiLSNVVVLGIF-IKYKELRTPTNA---VIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAG--- 97
Cdd:cd15141   3 HPATSTLMFAAGV---VGNLLALGILgVHRKERRTKSSAfcvLVTGLAATDLLGTCFLSPMVFVSYAQNSSLLGLAAgqp 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   98 -CQIYAGLNIFFGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILGA-WINGLFWALMPIIGWASYAPDPTGATC 175
Cdd:cd15141  80 lCHLFAFAMTFFGLASMLILFAMAVERCLAISHPYFYAQHSGRRLAKLALPAiYAFGALFCALPLLGVGRHKQYCPGTWC 159

                ....*...
gi 3024316  176 TINWRNND 183
Cdd:cd15141 160 FIRMTVPG 167
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
56-150 9.92e-04

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 40.28  E-value: 9.92e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   56 LRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGC--QIYagLNIFFGMVSIGLLTVVAMDRYLTISCP-DV 132
Cdd:cd15235  32 LHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGClaQMY--FFIAFGNTDSFLLAVMAYDRYVAICHPlHY 109
                        90
                ....*....|....*...
gi 3024316  133 GRRMTTNTYLSMILGAWI 150
Cdd:cd15235 110 ATVMSPKRCLLLVAGSWL 127
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
30-258 1.04e-03

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 40.08  E-value: 1.04e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   30 AYLIVAgITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIgYPMSAASDLHGS-WKFGHAGCQIYAgLNIFF 108
Cdd:cd15157   6 VYLIIF-VLGVVGNGLSIYVFLQPSKKKTSVNIFMLNLAVSDLMFVST-LPFRADYYLMGShWVFGDIACRIMS-YSLYV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  109 GM-VSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILGA-WINGLFWALMPIIGWASYAPDPTgaTCTINWRNNDTSF 186
Cdd:cd15157  83 NMyCSIYFLTVLSIVRFLAIVHPFKLWKVTSIKYARILCAViWIFVMAASSPLLSKGTSKYNSQT--KCLDLHPSKIDKL 160
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 3024316  187 VSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAASDctahlHRDWADQADVTKMSVIMILMFLLAWSPYSI 258
Cdd:cd15157 161 LILNYIVLVVGFILPFCTLSICYILIIKALLKPRVPQ-----SKLRVSHKKALLTIIITLILFLLCFLPYHI 227
7tmA_Mrgpr cd14973
mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G ...
57-294 1.22e-03

mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined. Also included in this family is Mas-related G-protein coupled receptor 1-like (MAS1L) which is only found in primates. The angiotensin-II metabolite angiotensin is an endogenous ligand for MAS1L.


Pssm-ID: 320104 [Multi-domain]  Cd Length: 272  Bit Score: 39.93  E-value: 1.22e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   57 RTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWkFGHAGCQIYAGLNIFFGMVSIGLLTVVAMDRYLTISCPD--VGR 134
Cdd:cd14973  31 RNPFSVYILNLAAADFLFLSCQAIQSLEDLLGGSL-PGFALCRLLATLMFFSYTVGLSLLAAISTERCLSVLFPIwyRCH 109
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  135 RmttNTYLSmilgAWINGLFWALMPIIGWasyapdPTGATCTINWRNNDTSFVSYTMMVIVVNFIVPLTVMFYCyyhvsr 214
Cdd:cd14973 110 R---PKHLS----AVVCALLWALSLLLSV------LESYFCGFLFWKFNESACRTFNFLSALLFLLLFLVMCVS------ 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  215 SLRLYAASDCTAHLHRdwadqadVTKMSVI---MILMFLLAWSPYSIVCLWACFGNPKKIPPSMAIIAPLFAKSSTFyNP 291
Cdd:cd14973 171 SLTLLIRVQCSSQRRP-------PTRLYVVillTVLVFLLCGLPLGIYWFLLLWFSNYLFHTFHPISDLLSCVNSSA-NP 242

                ...
gi 3024316  292 CIY 294
Cdd:cd14973 243 IIY 245
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
26-217 1.26e-03

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 40.16  E-value: 1.26e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   26 SVIAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGvSSIGYPMSAASDLHGSWKFGHAGCQIYAGLN 105
Cdd:cd15153   1 SLYATTYIIIFIPGLLANSAALWVLCRFISKKNKAIIFMINLAVADLA-HVLSLPLRIHYYIQHTWPFGRFLCLLCFYLK 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  106 IFFGMVSIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILGAWINgLFWALMPIIGWASYAPDPTGATCTINWRNNDTS 185
Cdd:cd15153  80 YLNMYASICFLTCISIQRCFFLLHPFKARDWKRRYDVGISAAVWIV-VGLACLPFPLLRSKSLSNNNRSCFADLGMKKLN 158
                       170       180       190
                ....*....|....*....|....*....|....*
gi 3024316  186 FVSYTMMVIVVN---FIVPLTVMFYCYYHVSRSLR 217
Cdd:cd15153 159 FGAAIAMMTVAElfgFVIPLFIIAWCTWKTENSLR 193
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
33-302 1.77e-03

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 39.34  E-value: 1.77e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   33 IVAGITSILSNVVVLGiFIKYKELRTPTNAVIINLAFTDIgVSSIGYPMS---AASDLHgsWKFGHAGCQIYAGLNIFFG 109
Cdd:cd15119   8 IVAFVLGVPGNAIVIW-VTGFKWKKTVNTLWFLNLAIADF-VFVLFLPLHityVALDFH--WPFGVWLCKINSFVAVLNM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  110 MVSIGLLTVVAMDRYLTISCPDVGRRMTTntylsmILGAWI-NGLFWALMPIIGW-ASYAPDPTGAT-----CTINWRNN 182
Cdd:cd15119  84 FASVLFLTVISLDRYISLAHPVWSHRYRT------LKSALIlCGIVWLSAAAISGpALYFRDTMELSinvtiCFNNFHKH 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  183 DTSFVSYTMMVIV-----VNFIVPLTVMFYCYyhvsrSLRLYAASDCTAhlhrdwADQADVTKMSVIMILMFLLAWSPYS 257
Cdd:cd15119 158 DGDLIVMRHTILVwvrffFGFLFPLLTMVVCY-----SLLAIKVKRRTL------LISSKFFWTISAVIVAFFVCWTPYH 226
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 3024316  258 IVCLWACFGNPKKIPPSMAIIAPLFAKSSTFYNPCI----YVAAHKKFR 302
Cdd:cd15119 227 IFSILELSIHHSSYLHNVLRAGIPLATSLAFINSCLnpilYVLIGKKFK 275
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
29-259 1.78e-03

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 39.40  E-value: 1.78e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   29 AAYLIVAgITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIgVSSIGYPMSAASDLHGS-WKFGHAGCQIYAGLniF 107
Cdd:cd15370   5 IVYIIVF-VVGLPSNAMALWVFLFRTKKKHPAVIYMANLALADL-LFVIWFPLKIAYHINGNnWIYGEALCKVLIGF--F 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  108 FGMV--SIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILGAWIngLFWAL---MPIIGWASYAPDPTGATCTINWRNN 182
Cdd:cd15370  81 YGNMycSILFMTCLSVQRYWVIVNPMSHSRKKANIAIGISLAIWL--LILLVtipLYLVKQTVFIPALDITTCHDVLPEQ 158
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 3024316  183 DTS--FVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRlYAASDCTAHLHRDWAdqadvTKMSVIMILMFLLAWSPYSIV 259
Cdd:cd15370 159 LLVgdMFNYFLSLAIGVFLFPAFLTAVAYVLMIRALK-SSINDESIEKKRKRA-----IKLIVTVLVMYLICFTPSNLL 231
7tmA_ET_R cd15128
endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
37-255 1.98e-03

endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are 21-amino acid peptides which able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320256 [Multi-domain]  Cd Length: 300  Bit Score: 39.43  E-value: 1.98e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   37 ITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGH-AGCQIYAGLNIFFGMVSIGL 115
Cdd:cd15128  12 IVGIIGNSTLLRIIYQNKCMRNGPNALIASLALGDLLYIVIDLPINVYKLLAMDWPFGDqPFGQFLCKLVPFIQKASVGI 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  116 ----LTVVAMDRYLTISC----PDVGRRMTTNTYLSMIlgaWINGLFWALMPIIGWASYAPDPTGATCTINWRNNDTSFV 187
Cdd:cd15128  92 tvlnLCALSVDRYRAVASwsriQGIGIPMWTAVEIVMI---WMLSAVLAVPEAIGFDMVRFNYKGVTLRTCLLRPETSFM 168
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 3024316  188 SYTMMV-----IVVNFIVPLTVMFYCYYHVSRSLRLYAASDCTAHLHRDWADQADVTKMSVIMILMFLLAWSP 255
Cdd:cd15128 169 KFYIDVkdwwlFGFYFCLPLVCTAIFYTLMTCEMLRKRNGMLRIALNEHLKQRREVAKTVFCLVVIFALCWLP 241
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
37-154 2.80e-03

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 38.78  E-value: 2.80e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   37 ITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFGMVSIGLL 116
Cdd:cd15231  12 LVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVSFVGTECLLL 91
                        90       100       110
                ....*....|....*....|....*....|....*....
gi 3024316  117 TVVAMDRYLTISCP-DVGRRMTTNTYLSMILGAWINGLF 154
Cdd:cd15231  92 AVMAYDRYVAICNPlHYAVIMSRKVCLQLAAASWLCGFL 130
7tmA_FFAR cd14983
free fatty acid receptors, member of the class A family of seven-transmembrane G ...
42-258 3.01e-03

free fatty acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the free fatty acid receptors (FFARs) which bind free fatty acids (FFAs). They belong to the class A G-protein coupled receptors and are composed of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR1 is a receptor for medium- and long-chain FFAs, whereas FFAR2 and FFAR3 are receptors for short chain FFAs (SCFAs), which have different ligand affinities. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and also indirectly increases insulin secretion by enhancing the release of incretin. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to the inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320114 [Multi-domain]  Cd Length: 278  Bit Score: 38.95  E-value: 3.01e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   42 SNVVVLGIFIKYKELRTPTNAV-IINLAFTDIgVSSIGYPMSAASDLHGSWKFGHAGCQIYAglNIFFGMV--SIGLLTV 118
Cdd:cd14983  17 SNLLALYAFVNRARLRLTPNVIyMINLCLSDL-VFILSLPIKIVEALSSAWTLPAVLCPLYN--LAHFSTLyaSTCFLTA 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  119 VAMDRYLTISCPdvgrrMTTNTYLSMILGAWINGLFWALM------------PIIGWASYAPDPTGATCTINWRNNDTSF 186
Cdd:cd14983  94 ISAGRYLGVAFP-----IKYQLYKKPLYSCLVCVAIWALVifhvtlvfiletSGGTLDINTPVGNSSTCYENFTPEQLAL 168
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 3024316  187 VSYTMMVI-VVNFIVPLTVMFYCYYhvsRSLRLYAASDCTAHLHRdwadqaDVTKMSVIMILMFLLAWSPYSI 258
Cdd:cd14983 169 LAPVRLELsLVLFFLPLAITAFCYV---RCIRILVRSRLHERRKR------RAVRVAVSTLLTFVVCFGPYNI 232
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
88-261 3.31e-03

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 38.62  E-value: 3.31e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   88 HGSWKFGHAGCQIYAGL---NIFfgmVSIGLLTVVAMDRYLTISCP---DVGRRMTTNTYLSMILgaWINGLFWALMPII 161
Cdd:cd15366  63 RDNWIHGPESCKLFGFIfytNIY---ISIAFLCCISVDRYLAVAHPlrfAKVRRVKTAVAVSAVV--WAIEIGANSAPLF 137
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  162 GWASYAPdptgatctinwRNNDT-SFVSYTM---------MVIVVNFIVPLTVMFYCYYHVSRSLRlyaasdCTAHLHRD 231
Cdd:cd15366 138 HDELFRD-----------RYNHTfCFEKYPMedwvawmnlYRVFVGFLFPWVLMLFSYRGILRAVR------GNVSTEQQ 200
                       170       180       190
                ....*....|....*....|....*....|
gi 3024316  232 waDQADVTKMSVIMILMFLLAWSPYSIVCL 261
Cdd:cd15366 201 --EKAKIKRLALSLIAIVLLCFAPYHVLLL 228
7tmA_OR6N-like cd15914
olfactory receptor OR6N and related proteins, member of the class A family of ...
40-168 3.33e-03

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320580 [Multi-domain]  Cd Length: 270  Bit Score: 38.51  E-value: 3.33e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   40 ILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGC--QIYaglniFF---GMVSIG 114
Cdd:cd15914  15 ITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCllQMY-----FFhslGITECY 89
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 3024316  115 LLTVVAMDRYLTISCP-DVGRRMTTNTYLSMILGAWINGLFWALMPIIgWASYAP 168
Cdd:cd15914  90 LLTAMAYDRYLAICNPlHYPSIMTPKLCTQLAAGCWLCGFLGPVPEII-LISTLP 143
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
112-305 3.35e-03

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 38.65  E-value: 3.35e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  112 SIGLLTVVAMDRYLTIScpdvgRRMTTNTYLSMILGAWINGLFW------ALMPI-IGWASYAPDPT---GATCTINWrn 181
Cdd:cd14989  85 SIFFLTWMSFDRYIALA-----KVMKSSPLRTMQHARLSCGLIWmasisaTLLPFtAVQAQHTGEVHfcfADVREIQW-- 157
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  182 ndtsfvsytmMVIVVNFIVPLTVMFYCYYHVSRSLrlyaasdCTAHLHRD-WADQADVTKMSVIMILMFLLAWSP----Y 256
Cdd:cd14989 158 ----------LEVTLGFIIPFSIIGLCYSLIVRVL-------VRAQKHRRlRPRRQKALRMILVVVLVFFICWLPenvfI 220
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 3024316  257 SIVCLWACFGNPKKIPPS-------MAIIAPLFAKSSTFYNPCIYVAAHKKFRKAM 305
Cdd:cd14989 221 SIQLLQGTQEPSESYDESfrhnhplTGHIVNLAAFSNSCLNPLIYSFLGETFRDKL 276
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
32-258 3.59e-03

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 38.52  E-value: 3.59e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   32 LIVAGITSILSNVVVLGIFIKYKelRTPTNAVII---NLAFTDIgVSSIGYPMSAASDLHG-SWKFGHAGCQIYAGLNIF 107
Cdd:cd15376   7 LGVEFLVAVLGNGLALWLFVTRE--RRPWHTGVVfsfNLAVSDL-LYALSLPLLAAYYYPPkNWRFGEAACKLERFLFTC 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  108 FGMVSIGLLTVVAMDRYLTISCPdvgrrMTTNTYLSMILGAWINGLFWAL-----MPIIGWASYAPDPTGATCTINWRNN 182
Cdd:cd15376  84 NLYGSIFFITCISLNRYLGIVHP-----FFTRSHVRPKHAKLVSLAVWLLvaalsAPVLSFSHLEVERHNKTECLGTAVD 158
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 3024316  183 DT--SFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRlyaasdctAHLHRDWADQADVTKMSVIMILMFLLAWSPYSI 258
Cdd:cd15376 159 SRlpTYLPYSLFLAVVGCGLPFLLTLASYLAIVWAVL--------RSPGITTLEKRKVAALVAVVVALYAVSFVPYHI 228
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
57-303 4.01e-03

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 38.56  E-value: 4.01e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   57 RTPTNAVIINLAFTDIGVS-SIGYPM-SAASDLHgsWKFGHAGCQIYAGLNIFFGMVSIGLLTVVAMDRYLTISCPDVGR 134
Cdd:cd15117  31 RTVTTVCFLNLAVADFAFClFLPFSVvYTALGFH--WPFGWFLCKLYSTLVVFNLFASVFLLTLISLDRCVSVLWPVWAR 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  135 RMTTNTYLSM-ILGAWINGLFWALmPIIGWASYAPDPTGATCTIN---WRNNDTSFVSYTMMVI-----------VVNFI 199
Cdd:cd15117 109 NHRTPARAALvAVGAWLLALALSG-PHLVFRDTRKENGCTHCYLNfdpWNETAEDPVLWLETVVqrlsaqvitrfVLGFL 187
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  200 VPLTVMFYCYYHVSrslrlyaasdctAHLHRD-WADQADVTKMSVIMILMFLLAWSPYSIVC---LWACFGNPKKIPPSM 275
Cdd:cd15117 188 VPLVIIGGCYGLIA------------ARLWREgWVHSSRPFRVLTAVVAAFFLCWFPFHLVSlleLVVILNQKEDLNPLL 255
                       250       260       270
                ....*....|....*....|....*....|..
gi 3024316  276 AIIAPLfAKSSTFYNPC----IYVAAHKKFRK 303
Cdd:cd15117 256 ILLLPL-SSSLACVNSClnplLYVFVGRDFRE 286
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
28-217 5.12e-03

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 38.21  E-value: 5.12e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   28 IAAYLIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSS-----IGYPMsaasdLHGSWKFGHAGCQIya 102
Cdd:cd15200   3 LAPVLGIEFVLGLVGNGIALFIFCFHRRPWKSNTMYLLSLVVADFFLIInlpfrIDYYL-----RNEVWRFGATACQV-- 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  103 glNIFF----GMVSIGLLTVVAMDRYLTISCPDvgrrmTTNTYLSMILGAWINGLFWALMPIIGWASYAPD--PTGATCT 176
Cdd:cd15200  76 --NLFMlsmnRTASIVFLTAIALNRYLKVVHPH-----HQLSKASVGCAAKVAAGLWILILLLNIHLLLLDhvQSNSTCL 148
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 3024316  177 INWRNNDTSFVS-YTMMVIVVNFIVPLTVMFYCYYHVSRSLR 217
Cdd:cd15200 149 SYDHGTDPSASDrWHRILFFLEFFLPLGIILFCIFSIILTLK 190
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
37-228 5.62e-03

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 38.03  E-value: 5.62e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   37 ITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGC--QIYAGLNifFGMVSIG 114
Cdd:cd15237  12 LLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCaaQMFFFLA--LGVTECV 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  115 LLTVVAMDRYLTISCP-DVGRRMTTNTYLSMILGAWINGLFWALMpIIGWASYAPdptgaTCTINWRNN----------- 182
Cdd:cd15237  90 LLAVMAYDRYVAICNPlRYSVIMSRRVCVRLAATSWASGFLNSLV-LTSLTLRLP-----FCGPNHINHffceapavlkl 163
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 3024316  183 ---DTSFVSYTMMVI-VVNFIVPLTVMFYCYYHV--------SRSLRLYAASDCTAHL 228
Cdd:cd15237 164 acaDTSLNEAVIFVTsVLVLLIPFSLILASYIRIlatilriqSAEGRKKAFSTCASHL 221
7tmA_GPR12 cd15961
G protein-coupled receptor 12, member of the class A family of seven-transmembrane G ...
32-305 6.09e-03

G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320627 [Multi-domain]  Cd Length: 268  Bit Score: 37.70  E-value: 6.09e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   32 LIVAGITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIgVSSIGYPmsaasdLHGSWKF---GHAGCQIYAGLNIFF 108
Cdd:cd15961   7 LCTSGTLISCENAIVVLIIFQNPSLRAPMFLLIGSLALADL-LAGIGLI------LNFIFAYllqSEAAKLVTVGLIVAS 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  109 GMVSIGLLTVVAMDRYLTI--SCPDVGRRMTTNTYLSMILgAWINGLFWALMPIIGWASYAPDPTGATCTINWRNNdtsf 186
Cdd:cd15961  80 FSASVCSLLAITVDRYLSLyyALTYNSERTVTFTYVMLVL-LWGASICLGLLPVMGWNCLADESTCSVVRPLTKNN---- 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  187 vsytMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAASDCTAHlHRDWADQADVTKMSV----IMILMFLLAWSPYSIVCLW 262
Cdd:cd15961 155 ----AAILSVSFLLMFALMLQLYIQICKIVMRHAHQIALQH-HFLATSHYVTTRKGVstlaIILGTFAACWMPFTLYSLI 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 3024316  263 ACFgnpkKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRKAM 305
Cdd:cd15961 230 ADY----TYPSIYTYATLLPATYNSIINPVIYAFRNQEIQKAL 268
7tmA_LPAR2_Edg4 cd15342
lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial ...
112-303 6.36e-03

lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial differentiation gene 4 (Edg4), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320464 [Multi-domain]  Cd Length: 274  Bit Score: 37.86  E-value: 6.36e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  112 SIGLLTVVAMDRYLTISCPDVGRRMTTNTYLSMILGAWINGLFWALMPIIGWasyapdptgaTCTINWRNNDT------- 184
Cdd:cd15342  86 SVANLLAIAVERHQTIFTMQLHSKMSNQRVVILIFGIWMVALILGLIPAMGW----------NCLCDLKRCSTmaplysr 155
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  185 SFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAASDCTAHLHRDwaDQADVTKMSVIMILMFLLAWSPYSIVCLWAC 264
Cdd:cd15342 156 SYLVFWALSNLLTFLIMVAVYTRIFIYVRRKSQRMSEHHSSHPRYRE--TVLGLMKTVVIILGAFVVCWTPGQVVLLLDG 233
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 3024316  265 FGNPKKIPPSMAIIAPLFAKSSTFYNPCIYVAAHKKFRK 303
Cdd:cd15342 234 LGCESCNVLAYEKYFLLLAEINSLVNPIVYSYRDKEMRK 272
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
37-158 7.31e-03

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 37.58  E-value: 7.31e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   37 ITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQIYAGLNIFFGMVSIGLL 116
Cdd:cd15229  12 LLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFFFFAGTEAFLL 91
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 3024316  117 TVVAMDRYLTISCP-DVGRRMTTNTYLSMILGAWINGLFWALM 158
Cdd:cd15229  92 SAMAYDRYAAICHPlHYVQIMSKQVCVQLVGGAWALGFLYALI 134
7tmA_GPR82 cd14996
orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G ...
37-127 7.33e-03

orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 82 of unknown function. GPR82 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320127 [Multi-domain]  Cd Length: 305  Bit Score: 37.86  E-value: 7.33e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   37 ITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSiGYPMSAASDLHGS-WKFGHAGCQI---YAGLNIFFGM-V 111
Cdd:cd14996  12 VTGVFGNLLSLWVFLTKISKKTSTHIYLINLVTANLLVCS-AMPFQAAYFLKGFyWKYQSTQCRIanfFGTLVIHVSMcV 90
                        90
                ....*....|....*.
gi 3024316  112 SIGLLTVVAMDRYLTI 127
Cdd:cd14996  91 SILILSWIAISRYATL 106
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
44-258 7.98e-03

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 37.39  E-value: 7.98e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   44 VVVLGIFIKYKELRTpTNAVIINLAFTDIgVSSIGYPMSAASDLHGSWKFGHAGCQ-----IYAGLNIffgmvSIGLLTV 118
Cdd:cd15378  20 IVILGYIFCLKNWKS-SNIYLFNLSVSDL-AFLCTLPMLVYSYSNGQWLFGDFLCKsnrylLHANLYS-----SILFLTF 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  119 VAMDRYLTISCPD----VGRRmttNTYLSMILGAWInGLFWALMPIIGWASYAPDPTGATCT-INWRNNDTSFVSYTMMV 193
Cdd:cd15378  93 ISIDRYLLIKYPFrehiLQKK---RSAVAISLAIWV-LVTLELLPILTFIGPNLKDNVTKCKdYASSGDATNSLIYSLFL 168
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 3024316  194 IVVNFIVPLTVMFYCYYHVSRSLRLYAASDCTAhlhrdwADQADVTKMSVIMILMFLLAWSPYSI 258
Cdd:cd15378 169 TVTGFLIPLCVMCFFYYKIALFLKNRNRQLANA------TSFEKPLTLVILAVVIFSVLFTPYHV 227
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
88-268 8.66e-03

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 37.45  E-value: 8.66e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   88 HGSWKFGHAGCQIYAGLNIFFGMVSIGLLTVVAMDRYLTISCP---DVGRRMTTNTYLSMILgaW-INGLFWALMpiIGW 163
Cdd:cd15365  63 GDNWTLSGFVCIFSAFLLYTNFYTSTALLTCIALDRYLAVVHPlkfMHLRTIRTALSVSVAI--WlLEICFNAVI--LTW 138
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316  164 ASYAPDPTGATCTINWRNNDTSFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAASDCTahlhrdwaDQADVTKMSV 243
Cdd:cd15365 139 EDSFHESSSHTLCYDKFPLEDWQARLNLFRICLGYLLPLLIILFCYWKIYQAVRSNQATEDQ--------EKKKIFKLLL 210
                       170       180
                ....*....|....*....|....*
gi 3024316  244 IMILMFLLAWSPYSIVCLWACFGNP 268
Cdd:cd15365 211 LITVTFVICFTPYHVVLLIRSIVEP 235
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
56-158 9.71e-03

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 37.14  E-value: 9.71e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   56 LRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCqiyaGLNIFFGMVSIG----LLTVVAMDRYLTISCP- 130
Cdd:cd15421  31 LHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGC----GTQIFFFLTLGGaeclLLALMAYDRYVAICHPl 106
                        90       100       110
                ....*....|....*....|....*....|
gi 3024316  131 --DVgrRMTTNTYLSMILGAWINGLFWALM 158
Cdd:cd15421 107 ryPV--LMSPRVCLLMAAGSWLGGSLNSLI 134
7tmA_OR1E-like cd15236
olfactory receptor subfamily 1E and related proteins, member of the class A family of ...
37-158 9.89e-03

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320364 [Multi-domain]  Cd Length: 277  Bit Score: 37.05  E-value: 9.89e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024316   37 ITSILSNVVVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGC--QIYagLNIFFGMVSIG 114
Cdd:cd15236  12 LTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCisQMY--FFIFFGCLDSF 89
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 3024316  115 LLTVVAMDRYLTISCP-DVGRRMTTNTYLSMILGAWINGLFWALM 158
Cdd:cd15236  90 LLAVMAYDRYVAICHPlHYTAIMRPELCVLLVAGSWVLTCFHALL 134
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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