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Conserved domains on  [gi|317373385|sp|O75581|]
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RecName: Full=Low-density lipoprotein receptor-related protein 6; Short=LRP-6; Flags: Precursor

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 150-191 1.23e-12

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 63.33  E-value: 1.23e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 317373385   150 GFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDY 191
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 592-627 2.33e-12

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 62.65  E-value: 2.33e-12
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 317373385   592 CAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTC 627
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1326-1360 2.44e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 62.61  E-value: 2.44e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 317373385 1326 CLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1360
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 483-524 2.78e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 62.62  E-value: 2.78e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 317373385    483 VLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGR 524
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1288-1322 4.10e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.84  E-value: 4.10e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 317373385 1288 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC 1322
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 397-437 6.90e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 61.46  E-value: 6.90e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 317373385    397 VVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMR 437
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 458-499 1.20e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 60.64  E-value: 1.20e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 317373385   458 GYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDY 499
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 286-323 3.36e-11

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 59.18  E-value: 3.36e-11
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 317373385   286 CGIDNGGCSHLCLMSPVKpfYQCACPTGVKLLENGKTC 323
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGG--YTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 697-739 3.74e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.15  E-value: 3.74e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 317373385    697 EHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHR 739
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 893-929 4.08e-11

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 59.18  E-value: 4.08e-11
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 317373385   893 CASSNGHCSHLCLAVPvGGFVCGCPAHYSLNADNRTC 929
Cdd:pfam14670    1 CSVNNGGCSHLCLNTP-GGYTCSCPEGYELQDDGRTC 36
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
654-813 7.87e-11

DNA-binding beta-propeller fold protein YncE [General function prediction only];


:

Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 63.94  E-value: 7.87e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  654 VAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGlDYPEGMAVDWLGKNLYWADTGTNRieVSK 733
Cdd:COG3391    60 LGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVATIPVG-GGPRGLAVDPDGGRLYVADSGNGR--VSV 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  734 LDGQHRQVL-VWKDLDSPRALALDPAEGFMYWTEWGGKP------KIDRAAMdgsERTTLVPNVGRANGLTIDYAKRRLY 806
Cdd:COG3391   137 IDTATGKVVaTIPVGAGPHGIAVDPDGKRLYVANSGSNTvsvivsVIDTATG---KVVATIPVGGGPVGVAVSPDGRRLY 213


                  ....*..
gi 317373385  807 WTDLDTN 813
Cdd:COG3391   214 VANRGSN 220
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1249-1285 2.18e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 56.83  E-value: 2.18e-10
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 317373385 1249 CSPQQFTCFTGEidCIPVAWRCDGFTECEDHSDELNC 1285
Cdd:cd00112     1 CPPNEFRCANGR--CIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 175-216 1.03e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.30  E-value: 1.03e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 317373385    175 IIINSEIYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNR 216
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 89-127 1.12e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.22  E-value: 1.12e-08
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 317373385     89 VVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGS 127
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1207-1243 1.56e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 51.86  E-value: 1.56e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 317373385  1207 CAQDNGGCSHICLVKGDGTTrCSCPMHLVLLQDELSC 1243
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYT-CSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 353-393 3.02e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 48.37  E-value: 3.02e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 317373385    353 VLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSG 393
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1094-1136 5.65e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 47.60  E-value: 5.65e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 317373385   1094 EVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANR 1136
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1-204 6.53e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


:

Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 49.31  E-value: 6.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385    1 MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGL----IYWSDVSEEAIK 76
Cdd:COG3391    14 AVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGAdgrrLYVANSGSGRVS 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385   77 RTEFNKTESVQNVVVSGllSPDGLACDWLGEKLYWTDSETNRIEVsnLDGSLRKVL-FWQELDQPRAIALDPSSGFMYWT 155
Cdd:COG3391    94 VIDLATGKVVATIPVGG--GPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVaTIPVGAGPHGIAVDPDGKRLYVA 169

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 317373385  156 DWG--EVPKIERAgMDGSSRFII--INSEIYwPNGLTLDYEEQKLYWADAKLN 204
Cdd:COG3391   170 NSGsnTVSVIVSV-IDTATGKVVatIPVGGG-PVGVAVSPDGRRLYVANRGSN 220
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 827-866 7.87e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 41.43  E-value: 7.87e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 317373385    827 VIADDLPHPFGLT--QYQDYIYWTDWSRRSIERANKTsGQNR 866
Cdd:smart00135    3 LLSSGLGHPNGLAvdWIEGRLYWTDWGLDVIEVANLD-GTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 958-998 2.51e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 39.89  E-value: 2.51e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 317373385    958 ILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQ 998
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 525-558 2.77e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 39.89  E-value: 2.77e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 317373385    525 RVLVEDKIPHIFGFTL--LGDYVYWTDWQRRSIERV 558
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVA 36
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
968-1075 6.34e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


:

Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 43.14  E-value: 6.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  968 RAIDYDPLDKQLYWIDSRQNMIRKAqeDGSQGftVVVSSVPsqnLEIQPYDLSIDIYSRYIYWTCEATN---VInVTRLD 1044
Cdd:COG3391   113 RGLAVDPDGGRLYVADSGNGRVSVI--DTATG--KVVATIP---VGAGPHGIAVDPDGKRLYVANSGSNtvsVI-VSVID 184

                          90       100       110
                  ....*....|....*....|....*....|...
gi 317373385 1045 GRSvGVVLK--GEQDRPRAVVVNPEKGYMYFTN 1075
Cdd:COG3391   185 TAT-GKVVAtiPVGGGPVGVAVSPDGRRLYVAN 216
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 217-251 8.94e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 38.35  E-value: 8.94e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 317373385    217 QAVVKGSLPHP--FALTLFEDILYWTDWSTHSILACN 251
Cdd:smart00135    1 RTLLSSGLGHPngLAVDWIEGRLYWTDWGLDVIEVAN 37
 
Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 150-191 1.23e-12

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 63.33  E-value: 1.23e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 317373385   150 GFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDY 191
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 592-627 2.33e-12

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 62.65  E-value: 2.33e-12
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 317373385   592 CAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTC 627
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1326-1360 2.44e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 62.61  E-value: 2.44e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 317373385 1326 CLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1360
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 483-524 2.78e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 62.62  E-value: 2.78e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 317373385    483 VLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGR 524
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1288-1322 4.10e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.84  E-value: 4.10e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 317373385 1288 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC 1322
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 397-437 6.90e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 61.46  E-value: 6.90e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 317373385    397 VVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMR 437
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 458-499 1.20e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 60.64  E-value: 1.20e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 317373385   458 GYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDY 499
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 286-323 3.36e-11

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 59.18  E-value: 3.36e-11
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 317373385   286 CGIDNGGCSHLCLMSPVKpfYQCACPTGVKLLENGKTC 323
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGG--YTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 697-739 3.74e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.15  E-value: 3.74e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 317373385    697 EHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHR 739
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 893-929 4.08e-11

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 59.18  E-value: 4.08e-11
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 317373385   893 CASSNGHCSHLCLAVPvGGFVCGCPAHYSLNADNRTC 929
Cdd:pfam14670    1 CSVNNGGCSHLCLNTP-GGYTCSCPEGYELQDDGRTC 36
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
654-813 7.87e-11

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 63.94  E-value: 7.87e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  654 VAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGlDYPEGMAVDWLGKNLYWADTGTNRieVSK 733
Cdd:COG3391    60 LGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVATIPVG-GGPRGLAVDPDGGRLYVADSGNGR--VSV 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  734 LDGQHRQVL-VWKDLDSPRALALDPAEGFMYWTEWGGKP------KIDRAAMdgsERTTLVPNVGRANGLTIDYAKRRLY 806
Cdd:COG3391   137 IDTATGKVVaTIPVGAGPHGIAVDPDGKRLYVANSGSNTvsvivsVIDTATG---KVVATIPVGGGPVGVAVSPDGRRLY 213


                  ....*..
gi 317373385  807 WTDLDTN 813
Cdd:COG3391   214 VANRGSN 220
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1288-1322 9.06e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 58.03  E-value: 9.06e-11
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 317373385  1288 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC 1322
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 438-481 1.25e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.00  E-value: 1.25e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 317373385    438 KILISEDLEEPRAIVLDPMVGYMYWTDWGEiPKIERAALDGSDR 481
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1249-1285 2.18e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 56.83  E-value: 2.18e-10
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 317373385 1249 CSPQQFTCFTGEidCIPVAWRCDGFTECEDHSDELNC 1285
Cdd:cd00112     1 CPPNEFRCANGR--CIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1288-1319 4.47e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.10  E-value: 4.47e-10
                            10        20        30
                    ....*....|....*....|....*....|..
gi 317373385   1288 CSESQFQCASGQCIDGALRCNGDANCQDKSDE 1319
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1326-1357 6.05e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.72  E-value: 6.05e-10
                            10        20        30
                    ....*....|....*....|....*....|..
gi 317373385   1326 CLIDQFRCANGQCIGKHKKCDHNVDCSDKSDE 1357
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 175-216 1.03e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.30  E-value: 1.03e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 317373385    175 IIINSEIYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNR 216
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1248-1282 1.46e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.56  E-value: 1.46e-09
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 317373385   1248 TCSPQQFTCFTGEidCIPVAWRCDGFTECEDHSDE 1282
Cdd:smart00192    1 TCPPGEFQCDNGR--CIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 130-173 2.08e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 54.53  E-value: 2.08e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 317373385    130 KVLFWQELDQPRAIALDPSSGFMYWTDWGEvPKIERAGMDGSSR 173
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1248-1285 5.73e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.02  E-value: 5.73e-09
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 317373385  1248 TCSPQQFTCFTGEidCIPVAWRCDGFTECEDHSDELNC 1285
Cdd:pfam00057    2 TCSPNEFQCGSGE--CIPRSWVCDGDPDCGDGSDEENC 37
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 361-523 8.54e-09

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 58.48  E-value: 8.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  361 HAIAIDYDpveGYIYWTDDEVRAIRR-----SFIDGSGSQFVVTAQIAHPDGIAVDwVARNLYWTDTGTDRIEVTRLNGT 435
Cdd:cd05819    58 AGVAVDSD---GNLYVADTGNHRIQKfdpdgNFLASFGGSGDGDGEFNGPRGIAVD-SSGNIYVADTGNHRIQKFDPDGE 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  436 MRKIL-----ISEDLEEPRAIVLDPmVGYMYWTDWgeipkieraaldGSDRVVLVNT----------------SLGWPNG 494
Cdd:cd05819   134 FLTTFgsggsGPGQFNGPTGVAVDS-DGNIYVADT------------GNHRIQVFDPdgnflttfgstgtgpgQFNYPTG 200

                         170       180
                  ....*....|....*....|....*....
gi 317373385  495 LALDyDEGKIYWGDAKTDKIEVMNTDGTG 523
Cdd:cd05819   201 IAVD-SDGNIYVADSGNNRVQVFDPDGAG 228
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 89-127 1.12e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.22  E-value: 1.12e-08
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 317373385     89 VVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGS 127
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1326-1360 1.21e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.87  E-value: 1.21e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 317373385  1326 CLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1360
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1207-1243 1.56e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 51.86  E-value: 1.56e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 317373385  1207 CAQDNGGCSHICLVKGDGTTrCSCPMHLVLLQDELSC 1243
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYT-CSCPEGYELQDDGRTC 36
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
361-528 2.17e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 56.63  E-value: 2.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  361 HAIAIDYDPVEGYIYWTDDEVRAIrrSFIDGSGSQFVVT-AQIAHPDGIAVDWVARNLYWTDTGTDRieVTRLNGTMRKI 439
Cdd:COG3391    69 DADGADAGADGRRLYVANSGSGRV--SVIDLATGKVVATiPVGGGPRGLAVDPDGGRLYVADSGNGR--VSVIDTATGKV 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  440 LISEDL-EEPRAIVLDPMVGYMYWTDWG--EIPKIErAALDGSDRVVLVNTSLG-WPNGLALDYDEGKIYWGDAKTDKie 515
Cdd:COG3391   145 VATIPVgAGPHGIAVDPDGKRLYVANSGsnTVSVIV-SVIDTATGKVVATIPVGgGPVGVAVSPDGRRLYVANRGSNT-- 221

                         170
                  ....*....|...
gi 317373385  516 vmnTDGTGRRVLV 528
Cdd:COG3391   222 ---SNGGSNTVSV 231
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 740-783 2.36e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 51.45  E-value: 2.36e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 317373385    740 QVLVWKDLDSPRALALDPAEGFMYWTEWgGKPKIDRAAMDGSER 783
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDW-GLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 415-455 9.93e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.47  E-value: 9.93e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 317373385   415 RNLYWTDTGTD-RIEVTRLNGTMRKILISEDLEEPRAIVLDP 455
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 107-147 1.26e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.47  E-value: 1.26e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 317373385   107 EKLYWTDSET-NRIEVSNLDGSLRKVLFWQELDQPRAIALDP 147
Cdd:pfam00058    1 GRLYWTDSSLrASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 353-393 3.02e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 48.37  E-value: 3.02e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 317373385    353 VLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSG 393
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1094-1136 5.65e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 47.60  E-value: 5.65e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 317373385   1094 EVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANR 1136
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 760-800 1.52e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 46.38  E-value: 1.52e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 317373385   760 GFMYWTEWGGKPKIDRAAMDGSER-TTLVPNVGRANGLTIDY 800
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRkTLFTDDLQHPNAIAVDP 42
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1-204 6.53e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 49.31  E-value: 6.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385    1 MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGL----IYWSDVSEEAIK 76
Cdd:COG3391    14 AVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGAdgrrLYVANSGSGRVS 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385   77 RTEFNKTESVQNVVVSGllSPDGLACDWLGEKLYWTDSETNRIEVsnLDGSLRKVL-FWQELDQPRAIALDPSSGFMYWT 155
Cdd:COG3391    94 VIDLATGKVVATIPVGG--GPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVaTIPVGAGPHGIAVDPDGKRLYVA 169

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 317373385  156 DWG--EVPKIERAgMDGSSRFII--INSEIYwPNGLTLDYEEQKLYWADAKLN 204
Cdd:COG3391   170 NSGsnTVSVIVSV-IDTATGKVVatIPVGGG-PVGVAVSPDGRRLYVANRGSN 220
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 699-813 1.36e-05

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 48.36  E-value: 1.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  699 VVEF-GLDYPEGMAVDWLGkNLYWADTGTNRieVSKLD-GQHRQ-VLVWKDLDSPRALALDPAeGFMYWTEWGGKPKIDR 775
Cdd:cd14952     3 VLPFtGLDGPGGVAVDAAG-NVYVADSGNNR--VLKLAaGSTTQtVLPFTGLYQPQGVAVDAA-GTVYVTDFGNNRVLKL 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 317373385  776 AAmdGSERTTLVP--NVGRANGLTIDyAKRRLYWTDLDTN 813
Cdd:cd14952    79 AA--GSTTQTVLPftGLNDPTGVAVD-AAGNVYVADTGNN 115
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 718-757 4.66e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 42.15  E-value: 4.66e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 317373385   718 NLYWADTGT-NRIEVSKLDGQHRQVLVWKDLDSPRALALDP 757
Cdd:pfam00058    2 RLYWTDSSLrASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 827-866 7.87e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 41.43  E-value: 7.87e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 317373385    827 VIADDLPHPFGLT--QYQDYIYWTDWSRRSIERANKTsGQNR 866
Cdd:smart00135    3 LLSSGLGHPNGLAvdWIEGRLYWTDWGLDVIEVANLD-GTNR 43
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 55-272 2.44e-04

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 44.62  E-value: 2.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385   55 AVDfvfSHGLIYWSDVSEEAIKRteFNK-TESVQNVVVSG-----LLSPDGLACDWLGEkLYWTDSETNRIEVSNLDGSL 128
Cdd:cd05819    14 AVD---SSGNIYVADTGNNRIQV--FDPdGNFITSFGSFGsgdgqFNEPAGVAVDSDGN-LYVADTGNHRIQKFDPDGNF 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  129 RKV-----LFWQELDQPRAIALDpSSGFMYWTDWGEVpKIERAGMDGSSRFII-----INSEIYWPNGLTLDyEEQKLYW 198
Cdd:cd05819    88 LASfggsgDGDGEFNGPRGIAVD-SSGNIYVADTGNH-RIQKFDPDGEFLTTFgsggsGPGQFNGPTGVAVD-SDGNIYV 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  199 ADAKLNFIHKSNLDGT-----NRQAVVKGSLPHPFALTLFED-ILYWTDWSTHSILacnKYTGEGLREI--------HSD 264
Cdd:cd05819   165 ADTGNHRIQVFDPDGNflttfGSTGTGPGQFNYPTGIAVDSDgNIYVADSGNNRVQ---VFDPDGAGFGgngnflgsDGQ 241


                  ....*...
gi 317373385  265 IFSPMDIH 272
Cdd:cd05819   242 FNRPSGLA 249
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 958-998 2.51e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 39.89  E-value: 2.51e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 317373385    958 ILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQ 998
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 525-558 2.77e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 39.89  E-value: 2.77e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 317373385    525 RVLVEDKIPHIFGFTL--LGDYVYWTDWQRRSIERV 558
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVA 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 372-412 3.89e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 39.45  E-value: 3.89e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 317373385   372 GYIYWTDDEVRA-IRRSFIDGSGSQFVVTAQIAHPDGIAVDW 412
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
968-1075 6.34e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 43.14  E-value: 6.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  968 RAIDYDPLDKQLYWIDSRQNMIRKAqeDGSQGftVVVSSVPsqnLEIQPYDLSIDIYSRYIYWTCEATN---VInVTRLD 1044
Cdd:COG3391   113 RGLAVDPDGGRLYVADSGNGRVSVI--DTATG--KVVATIP---VGAGPHGIAVDPDGKRLYVANSGSNtvsVI-VSVID 184

                          90       100       110
                  ....*....|....*....|....*....|...
gi 317373385 1045 GRSvGVVLK--GEQDRPRAVVVNPEKGYMYFTN 1075
Cdd:COG3391   185 TAT-GKVVAtiPVGGGPVGVAVSPDGRRLYVAN 216
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 217-251 8.94e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 38.35  E-value: 8.94e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 317373385    217 QAVVKGSLPHP--FALTLFEDILYWTDWSTHSILACN 251
Cdd:smart00135    1 RTLLSSGLGHPngLAVDWIEGRLYWTDWGLDVIEVAN 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1114-1154 1.26e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 37.91  E-value: 1.26e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 317373385  1114 GKLFWADSDLR-RIESSDLSGANRIVLEDSNILQPVGLTVFE 1154
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 704-770 5.27e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 40.76  E-value: 5.27e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 317373385  704 LDYPEGMAVDWLGkNLYWADTGTNRIevSKLDGQHRQVLVW-------KDLDSPRALALDPAeGFMYWTEWGGK 770
Cdd:cd05819    54 FNEPAGVAVDSDG-NLYVADTGNHRI--QKFDPDGNFLASFggsgdgdGEFNGPRGIAVDSS-GNIYVADTGNH 123
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1015-1048 9.79e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 35.66  E-value: 9.79e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 317373385   1015 QPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSV 1048
Cdd:smart00135   10 HPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
 
Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 150-191 1.23e-12

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 63.33  E-value: 1.23e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 317373385   150 GFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDY 191
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 592-627 2.33e-12

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 62.65  E-value: 2.33e-12
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 317373385   592 CAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTC 627
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1326-1360 2.44e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 62.61  E-value: 2.44e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 317373385 1326 CLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1360
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 483-524 2.78e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 62.62  E-value: 2.78e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 317373385    483 VLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGR 524
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1288-1322 4.10e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.84  E-value: 4.10e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 317373385 1288 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC 1322
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 397-437 6.90e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 61.46  E-value: 6.90e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 317373385    397 VVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMR 437
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 458-499 1.20e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 60.64  E-value: 1.20e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 317373385   458 GYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDY 499
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 286-323 3.36e-11

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 59.18  E-value: 3.36e-11
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 317373385   286 CGIDNGGCSHLCLMSPVKpfYQCACPTGVKLLENGKTC 323
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGG--YTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 697-739 3.74e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.15  E-value: 3.74e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 317373385    697 EHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHR 739
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 893-929 4.08e-11

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 59.18  E-value: 4.08e-11
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 317373385   893 CASSNGHCSHLCLAVPvGGFVCGCPAHYSLNADNRTC 929
Cdd:pfam14670    1 CSVNNGGCSHLCLNTP-GGYTCSCPEGYELQDDGRTC 36
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
654-813 7.87e-11

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 63.94  E-value: 7.87e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  654 VAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGlDYPEGMAVDWLGKNLYWADTGTNRieVSK 733
Cdd:COG3391    60 LGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVATIPVG-GGPRGLAVDPDGGRLYVADSGNGR--VSV 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  734 LDGQHRQVL-VWKDLDSPRALALDPAEGFMYWTEWGGKP------KIDRAAMdgsERTTLVPNVGRANGLTIDYAKRRLY 806
Cdd:COG3391   137 IDTATGKVVaTIPVGAGPHGIAVDPDGKRLYVANSGSNTvsvivsVIDTATG---KVVATIPVGGGPVGVAVSPDGRRLY 213


                  ....*..
gi 317373385  807 WTDLDTN 813
Cdd:COG3391   214 VANRGSN 220
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1288-1322 9.06e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 58.03  E-value: 9.06e-11
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 317373385  1288 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC 1322
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 438-481 1.25e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.00  E-value: 1.25e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 317373385    438 KILISEDLEEPRAIVLDPMVGYMYWTDWGEiPKIERAALDGSDR 481
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1249-1285 2.18e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 56.83  E-value: 2.18e-10
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 317373385 1249 CSPQQFTCFTGEidCIPVAWRCDGFTECEDHSDELNC 1285
Cdd:cd00112     1 CPPNEFRCANGR--CIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1288-1319 4.47e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.10  E-value: 4.47e-10
                            10        20        30
                    ....*....|....*....|....*....|..
gi 317373385   1288 CSESQFQCASGQCIDGALRCNGDANCQDKSDE 1319
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1326-1357 6.05e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.72  E-value: 6.05e-10
                            10        20        30
                    ....*....|....*....|....*....|..
gi 317373385   1326 CLIDQFRCANGQCIGKHKKCDHNVDCSDKSDE 1357
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 175-216 1.03e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.30  E-value: 1.03e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 317373385    175 IIINSEIYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNR 216
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1248-1282 1.46e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.56  E-value: 1.46e-09
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 317373385   1248 TCSPQQFTCFTGEidCIPVAWRCDGFTECEDHSDE 1282
Cdd:smart00192    1 TCPPGEFQCDNGR--CIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 130-173 2.08e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 54.53  E-value: 2.08e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 317373385    130 KVLFWQELDQPRAIALDPSSGFMYWTDWGEvPKIERAGMDGSSR 173
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1248-1285 5.73e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.02  E-value: 5.73e-09
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 317373385  1248 TCSPQQFTCFTGEidCIPVAWRCDGFTECEDHSDELNC 1285
Cdd:pfam00057    2 TCSPNEFQCGSGE--CIPRSWVCDGDPDCGDGSDEENC 37
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 361-523 8.54e-09

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 58.48  E-value: 8.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  361 HAIAIDYDpveGYIYWTDDEVRAIRR-----SFIDGSGSQFVVTAQIAHPDGIAVDwVARNLYWTDTGTDRIEVTRLNGT 435
Cdd:cd05819    58 AGVAVDSD---GNLYVADTGNHRIQKfdpdgNFLASFGGSGDGDGEFNGPRGIAVD-SSGNIYVADTGNHRIQKFDPDGE 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  436 MRKIL-----ISEDLEEPRAIVLDPmVGYMYWTDWgeipkieraaldGSDRVVLVNT----------------SLGWPNG 494
Cdd:cd05819   134 FLTTFgsggsGPGQFNGPTGVAVDS-DGNIYVADT------------GNHRIQVFDPdgnflttfgstgtgpgQFNYPTG 200

                         170       180
                  ....*....|....*....|....*....
gi 317373385  495 LALDyDEGKIYWGDAKTDKIEVMNTDGTG 523
Cdd:cd05819   201 IAVD-SDGNIYVADSGNNRVQVFDPDGAG 228
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 89-127 1.12e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.22  E-value: 1.12e-08
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 317373385     89 VVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGS 127
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1326-1360 1.21e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.87  E-value: 1.21e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 317373385  1326 CLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1360
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1207-1243 1.56e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 51.86  E-value: 1.56e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 317373385  1207 CAQDNGGCSHICLVKGDGTTrCSCPMHLVLLQDELSC 1243
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYT-CSCPEGYELQDDGRTC 36
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
361-528 2.17e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 56.63  E-value: 2.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  361 HAIAIDYDPVEGYIYWTDDEVRAIrrSFIDGSGSQFVVT-AQIAHPDGIAVDWVARNLYWTDTGTDRieVTRLNGTMRKI 439
Cdd:COG3391    69 DADGADAGADGRRLYVANSGSGRV--SVIDLATGKVVATiPVGGGPRGLAVDPDGGRLYVADSGNGR--VSVIDTATGKV 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  440 LISEDL-EEPRAIVLDPMVGYMYWTDWG--EIPKIErAALDGSDRVVLVNTSLG-WPNGLALDYDEGKIYWGDAKTDKie 515
Cdd:COG3391   145 VATIPVgAGPHGIAVDPDGKRLYVANSGsnTVSVIV-SVIDTATGKVVATIPVGgGPVGVAVSPDGRRLYVANRGSNT-- 221

                         170
                  ....*....|...
gi 317373385  516 vmnTDGTGRRVLV 528
Cdd:COG3391   222 ---SNGGSNTVSV 231
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 740-783 2.36e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 51.45  E-value: 2.36e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 317373385    740 QVLVWKDLDSPRALALDPAEGFMYWTEWgGKPKIDRAAMDGSER 783
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDW-GLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 783-825 8.86e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.91  E-value: 8.86e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 317373385    783 RTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNR 825
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 415-455 9.93e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.47  E-value: 9.93e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 317373385   415 RNLYWTDTGTD-RIEVTRLNGTMRKILISEDLEEPRAIVLDP 455
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 107-147 1.26e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.47  E-value: 1.26e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 317373385   107 EKLYWTDSET-NRIEVSNLDGSLRKVLFWQELDQPRAIALDP 147
Cdd:pfam00058    1 GRLYWTDSSLrASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 353-393 3.02e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 48.37  E-value: 3.02e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 317373385    353 VLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSG 393
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1094-1136 5.65e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 47.60  E-value: 5.65e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 317373385   1094 EVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANR 1136
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
361-549 9.10e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 52.00  E-value: 9.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  361 HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEV--TRLNGTMRK 438
Cdd:COG3391    26 AALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVidLATGKVVAT 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  439 ILISEDleePRAIVLDPMVGYMYWTDWGEiPKIerAALDGSDRVVLVNTSLG-WPNGLALDYDEGKIYWGDAKTDKI--- 514
Cdd:COG3391   106 IPVGGG---PRGLAVDPDGGRLYVADSGN-GRV--SVIDTATGKVVATIPVGaGPHGIAVDPDGKRLYVANSGSNTVsvi 179

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 317373385  515 -EVMNT-DGTGRRVLVEDKIPHIFGFTLLGDYVYWTD 549
Cdd:COG3391   180 vSVIDTaTGKVVATIPVGGGPVGVAVSPDGRRLYVAN 216
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 55-208 1.09e-06

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 51.94  E-value: 1.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385   55 AVDfvfSHGLIYWSDVSEEAIKRteFNKTESVQNVVVSG------LLSPDGLACDWLGeKLYWTDSETNRIEVSNLDGSL 128
Cdd:cd05819   108 AVD---SSGNIYVADTGNHRIQK--FDPDGEFLTTFGSGgsgpgqFNGPTGVAVDSDG-NIYVADTGNHRIQVFDPDGNF 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  129 rkVLFW-------QELDQPRAIALDpSSGFMYWTDWG--EVPKIERAGM--DGSSRFIIINSEIYWPNGLTLDyEEQKLY 197
Cdd:cd05819   182 --LTTFgstgtgpGQFNYPTGIAVD-SDGNIYVADSGnnRVQVFDPDGAgfGGNGNFLGSDGQFNRPSGLAVD-SDGNLY 257

                         170
                  ....*....|.
gi 317373385  198 WADAKLNFIHK 208
Cdd:cd05819   258 VADTGNNRIQV 268
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 760-800 1.52e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 46.38  E-value: 1.52e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 317373385   760 GFMYWTEWGGKPKIDRAAMDGSER-TTLVPNVGRANGLTIDY 800
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRkTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 656-694 2.96e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 45.29  E-value: 2.96e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 317373385    656 IPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGS 694
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1-204 6.53e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 49.31  E-value: 6.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385    1 MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGL----IYWSDVSEEAIK 76
Cdd:COG3391    14 AVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGAdgrrLYVANSGSGRVS 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385   77 RTEFNKTESVQNVVVSGllSPDGLACDWLGEKLYWTDSETNRIEVsnLDGSLRKVL-FWQELDQPRAIALDPSSGFMYWT 155
Cdd:COG3391    94 VIDLATGKVVATIPVGG--GPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVaTIPVGAGPHGIAVDPDGKRLYVA 169

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 317373385  156 DWG--EVPKIERAgMDGSSRFII--INSEIYwPNGLTLDYEEQKLYWADAKLN 204
Cdd:COG3391   170 NSGsnTVSVIVSV-IDTATGKVVatIPVGGG-PVGVAVSPDGRRLYVANRGSN 220
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 367-558 6.59e-06

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 49.51  E-value: 6.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  367 YDPvEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQiAHPDGIAVD-----WVARN---LYWTDTGTDRIEVtrlngtmrk 438
Cdd:COG3386    15 WDP-DGRLYWVDIPGGRIHRYDPDGGAVEVFAEPS-GRPNGLAFDpdgrlLVADHgrgLVRFDPADGEVTV--------- 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  439 ilISEDLEEPRA----IVLDPMvGYMYWTDwgeiPKIERAA-----LDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDA 509
Cdd:COG3386    84 --LADEYGKPLNrpndGVVDPD-GRLYFTD----MGEYLPTgalyrVDPDGSLRVLADGLTFPNGIAFSPDGRTLYVADT 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 317373385  510 KTDKIEVMNTDGTG----RRVLVEDKIPHIF--GFTLLGD-YVYWTDWQRRSIERV 558
Cdd:COG3386   157 GAGRIYRFDLDADGtlgnRRVFADLPDGPGGpdGLAVDADgNLWVALWGGGGVVRF 212
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
106-246 7.03e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 49.31  E-value: 7.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  106 GEKLYWTDSETNRIEVSNLDgSLRKVLFWQELDQPRAIALDPSSGFMYWTDW--GEVPKIeragmDGSSRFIIinSEI-- 181
Cdd:COG3391    79 GRRLYVANSGSGRVSVIDLA-TGKVVATIPVGGGPRGLAVDPDGGRLYVADSgnGRVSVI-----DTATGKVV--ATIpv 150

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 317373385  182 -YWPNGLTLDYEEQKLYWADAKLNFIHK--SNLDGTNRQaVVK----GSLPHPFALTLFEDILYWTDWSTHS 246
Cdd:COG3391   151 gAGPHGIAVDPDGKRLYVANSGSNTVSVivSVIDTATGK-VVAtipvGGGPVGVAVSPDGRRLYVANRGSNT 221
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 699-813 1.36e-05

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 48.36  E-value: 1.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  699 VVEF-GLDYPEGMAVDWLGkNLYWADTGTNRieVSKLD-GQHRQ-VLVWKDLDSPRALALDPAeGFMYWTEWGGKPKIDR 775
Cdd:cd14952     3 VLPFtGLDGPGGVAVDAAG-NVYVADSGNNR--VLKLAaGSTTQtVLPFTGLYQPQGVAVDAA-GTVYVTDFGNNRVLKL 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 317373385  776 AAmdGSERTTLVP--NVGRANGLTIDyAKRRLYWTDLDTN 813
Cdd:cd14952    79 AA--GSTTQTVLPftGLNDPTGVAVD-AAGNVYVADTGNN 115
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 362-514 1.40e-05

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 48.47  E-value: 1.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  362 AIAIDYDpveGYIYWTDDEVRAIRR-----SFIDGSGSQFVVTAQIAHPDGIAVDwVARNLYWTDTGTDRIEVTRLNGTm 436
Cdd:cd05819   153 GVAVDSD---GNIYVADTGNHRIQVfdpdgNFLTTFGSTGTGPGQFNYPTGIAVD-SDGNIYVADSGNNRVQVFDPDGA- 227

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 317373385  437 rkilisedleepraivldpmvgymYWTDWGEipkieraaldgsdrVVLVNTSLGWPNGLALDyDEGKIYWGDAKTDKI 514
Cdd:cd05819   228 ------------------------GFGGNGN--------------FLGSDGQFNRPSGLAVD-SDGNLYVADTGNNRI 266
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 703-813 1.94e-05

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 47.97  E-value: 1.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  703 GLDYPEGMAVDWLGkNLYWADTGTNRieVSKLDGQH--RQVLVWKDLDSPRALALDPAeGFMYWTEWGGKpKIDRAAMDG 780
Cdd:cd14952    92 GLNDPTGVAVDAAG-NVYVADTGNNR--VLKLAAGSntQTVLPFTGLSNPDGVAVDGA-GNVYVTDTGNN-RVLKLAAGS 166

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 317373385  781 SERTTLvPNVGRA--NGLTIDyAKRRLYWTDLDTN 813
Cdd:cd14952   167 TTQTVL-PFTGLNspSGVAVD-TAGNVYVTDHGNN 199
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 718-757 4.66e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 42.15  E-value: 4.66e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 317373385   718 NLYWADTGT-NRIEVSKLDGQHRQVLVWKDLDSPRALALDP 757
Cdd:pfam00058    2 RLYWTDSSLrASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 361-522 5.69e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 46.89  E-value: 5.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  361 HAIAIDYDpveGYIYWTDD----------EVRAIRRSFIDGSGSQfvvtaQIAHPDGIAVDwVARNLYWTDTGTDRIEVT 430
Cdd:cd14956    16 RGIAVDAD---DNVYVADArngriqvfdkDGTFLRRFGTTGDGPG-----QFGRPRGLAVD-KDGWLYVADYWGDRIQVF 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  431 RLNGTMRKILISE-----DLEEPRAIVLDPMvGYMYWTDWGEiPKIERAALDGSdrvvLVNT---------SLGWPNGLA 496
Cdd:cd14956    87 TLTGELQTIGGSSgsgpgQFNAPRGVAVDAD-GNLYVADFGN-QRIQKFDPDGS----FLRQwggtgiepgSFNYPRGVA 160

                         170       180
                  ....*....|....*....|....*.
gi 317373385  497 LDyDEGKIYWGDAKTDKIEVMNTDGT 522
Cdd:cd14956   161 VD-PDGTLYVADTYNDRIQVFDNDGA 185
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 827-866 7.87e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 41.43  E-value: 7.87e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 317373385    827 VIADDLPHPFGLT--QYQDYIYWTDWSRRSIERANKTsGQNR 866
Cdd:smart00135    3 LLSSGLGHPNGLAvdWIEGRLYWTDWGLDVIEVANLD-GTNR 43
DUF5050 pfam16472
Domain of unknown function (DUF5050);
373-549 1.46e-04

Domain of unknown function (DUF5050);


Pssm-ID: 465128 [Multi-domain]  Cd Length: 282  Bit Score: 45.70  E-value: 1.46e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385   373 YIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDgIAVDWVarnlYWTDTGTD-RIEVTRLNGTMRKILISEDLEEPraI 451
Cdd:pfam16472  111 YQHYDNSDGGTLYKIKIDGKEKTKLSDEPISPAS-VSDGWI----YYSGTSDDhYIYKLNTDGDSISKLYDGNSYMP--N 183

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385   452 VLDpmvGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNglaldYDEGKIYWGDAKTD-KIEVMNTDGTGRRVLVED 530
Cdd:pfam16472  184 VNG---DYIYYIDLSNNYALYRMNLSGGEKEVLTDDRVDNYN-----VYGNWIYYQNNGDDnKLYRINTDGSNKEKLAEG 255

                          170
                   ....*....|....*....
gi 317373385   531 KIPHIfgfTLLGDYVYWTD 549
Cdd:pfam16472  256 NYTNI---NITSDYIYFTD 271
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 673-857 1.59e-04

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 45.27  E-value: 1.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  673 DNRIYWTDISLKTISRAFMNGSALEHVVEFGlDYPEGMAVDWLGkNLYWADTGtNRIEVSKLDGQHRQVLV---WKDLDS 749
Cdd:COG3386    18 DGRLYWVDIPGGRIHRYDPDGGAVEVFAEPS-GRPNGLAFDPDG-RLLVADHG-RGLVRFDPADGEVTVLAdeyGKPLNR 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  750 PRALALDPAeGFMYWT---EWGGKPKIDRAAMDGsERTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLI-----ESSNML 821
Cdd:COG3386    95 PNDGVVDPD-GRLYFTdmgEYLPTGALYRVDPDG-SLRVLADGLTFPNGIAFSPDGRTLYVADTGAGRIyrfdlDADGTL 172

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 317373385  822 GlNREVIADDLPHPF---GLTQYQD-YIYWTDWSRRSIER 857
Cdd:COG3386   173 G-NRRVFADLPDGPGgpdGLAVDADgNLWVALWGGGGVVR 211
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 136-427 1.83e-04

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 45.00  E-value: 1.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  136 ELDQPRAIALDpSSGFMYWTDWGEVpKIERagMDGSSRFIII-------NSEIYWPNGLTLDYEEQkLYWADAKLNFIHK 208
Cdd:cd05819     6 ELNNPQGIAVD-SSGNIYVADTGNN-RIQV--FDPDGNFITSfgsfgsgDGQFNEPAGVAVDSDGN-LYVADTGNHRIQK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  209 SNLDGTNRQAVVK-----GSLPHPFALTL-FEDILYWTDWSTHSILACNKyTGEGLREIHS------DIFSPMDIhafsq 276
Cdd:cd05819    81 FDPDGNFLASFGGsgdgdGEFNGPRGIAVdSSGNIYVADTGNHRIQKFDP-DGEFLTTFGSggsgpgQFNGPTGV----- 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  277 qrqpnATNPCGI----DNGGCShlclmspVKPFYqcacPTGVKLLENGKTCKDGAtellllarrtdlrriSLDTPdftdi 352
Cdd:cd05819   155 -----AVDSDGNiyvaDTGNHR-------IQVFD----PDGNFLTTFGSTGTGPG---------------QFNYP----- 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  353 vlqledirHAIAIDYDpveGYIYWTDDEVRAIRR-----SFIDGSGSQFVVTAQIAHPDGIAVDwVARNLYWTDTGTDRI 427
Cdd:cd05819   199 --------TGIAVDSD---GNIYVADSGNNRVQVfdpdgAGFGGNGNFLGSDGQFNRPSGLAVD-SDGNLYVADTGNNRI 266
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 402-527 2.02e-04

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 44.89  E-value: 2.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  402 IAHPDGIAVDwVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPmVGYMYWTDWGEIPKIERAAlDGSDR 481
Cdd:cd14952     9 LDGPGGVAVD-AAGNVYVADSGNNRVLKLAAGSTTQTVLPFTGLYQPQGVAVDA-AGTVYVTDFGNNRVLKLAA-GSTTQ 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 317373385  482 VVLVNTSLGWPNGLALDyDEGKIYwgdaktdkieVmnTDGTGRRVL 527
Cdd:cd14952    86 TVLPFTGLNDPTGVAVD-AAGNVY----------V--ADTGNNRVL 118
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 674-714 2.31e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 40.22  E-value: 2.31e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 317373385   674 NRIYWTDISLK-TISRAFMNGSALEHVVEFGLDYPEGMAVDW 714
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 55-272 2.44e-04

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 44.62  E-value: 2.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385   55 AVDfvfSHGLIYWSDVSEEAIKRteFNK-TESVQNVVVSG-----LLSPDGLACDWLGEkLYWTDSETNRIEVSNLDGSL 128
Cdd:cd05819    14 AVD---SSGNIYVADTGNNRIQV--FDPdGNFITSFGSFGsgdgqFNEPAGVAVDSDGN-LYVADTGNHRIQKFDPDGNF 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  129 RKV-----LFWQELDQPRAIALDpSSGFMYWTDWGEVpKIERAGMDGSSRFII-----INSEIYWPNGLTLDyEEQKLYW 198
Cdd:cd05819    88 LASfggsgDGDGEFNGPRGIAVD-SSGNIYVADTGNH-RIQKFDPDGEFLTTFgsggsGPGQFNGPTGVAVD-SDGNIYV 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  199 ADAKLNFIHKSNLDGT-----NRQAVVKGSLPHPFALTLFED-ILYWTDWSTHSILacnKYTGEGLREI--------HSD 264
Cdd:cd05819   165 ADTGNHRIQVFDPDGNflttfGSTGTGPGQFNYPTGIAVDSDgNIYVADSGNNRVQ---VFDPDGAGFGgngnflgsDGQ 241


                  ....*...
gi 317373385  265 IFSPMDIH 272
Cdd:cd05819   242 FNRPSGLA 249
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 958-998 2.51e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 39.89  E-value: 2.51e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 317373385    958 ILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQ 998
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 525-558 2.77e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 39.89  E-value: 2.77e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 317373385    525 RVLVEDKIPHIFGFTL--LGDYVYWTDWQRRSIERV 558
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVA 36
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 361-522 2.97e-04

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 44.56  E-value: 2.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  361 HAIAIDYDpveGYIYWTDDEVRAIR-----RSFIDGSGSQFVVTAQIAHPDGIAVDwVARNLYWTDTGTDRIEV-TRLNG 434
Cdd:cd14957    21 RGIAVDSA---GNIYVADTGNNRIQvftssGVYSYSIGSGGTGSGQFNSPYGIAVD-SNGNIYVADTDNNRIQVfNSSGV 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  435 TMRKI----LISEDLEEPRAIVLDPMvGYMYWTDwgeipkieraalDGSDRVVLVNTS----------------LGWPNG 494
Cdd:cd14957    97 YQYSIgtggSGDGQFNGPYGIAVDSN-GNIYVAD------------TGNHRIQVFTSSgtfsysigsggtgpgqFNGPQG 163

                         170       180
                  ....*....|....*....|....*...
gi 317373385  495 LALDYDeGKIYWGDAKTDKIEVMNTDGT 522
Cdd:cd14957   164 IAVDSD-GNIYVADTGNHRIQVFTSSGT 190
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 372-412 3.89e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 39.45  E-value: 3.89e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 317373385   372 GYIYWTDDEVRA-IRRSFIDGSGSQFVVTAQIAHPDGIAVDW 412
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 705-785 5.35e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 43.81  E-value: 5.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  705 DYPEGMAVDwLGKNLYWADTGTNRIEVSKLDGQH-RQvlVWK------DLDSPRALALDPAEGFMYWTEWGGkpKIDRAA 777
Cdd:cd14956    13 KDPRGIAVD-ADDNVYVADARNGRIQVFDKDGTFlRR--FGTtgdgpgQFGRPRGLAVDKDGWLYVADYWGD--RIQVFT 87


                  ....*...
gi 317373385  778 MDGSERTT 785
Cdd:cd14956    88 LTGELQTI 95
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
968-1075 6.34e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 43.14  E-value: 6.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  968 RAIDYDPLDKQLYWIDSRQNMIRKAqeDGSQGftVVVSSVPsqnLEIQPYDLSIDIYSRYIYWTCEATN---VInVTRLD 1044
Cdd:COG3391   113 RGLAVDPDGGRLYVADSGNGRVSVI--DTATG--KVVATIP---VGAGPHGIAVDPDGKRLYVANSGSNtvsVI-VSVID 184

                          90       100       110
                  ....*....|....*....|....*....|...
gi 317373385 1045 GRSvGVVLK--GEQDRPRAVVVNPEKGYMYFTN 1075
Cdd:COG3391   185 TAT-GKVVAtiPVGGGPVGVAVSPDGRRLYVAN 216
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 401-527 8.22e-04

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 43.08  E-value: 8.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  401 QIAHPDGIAVDwVARNLYWTDTGTDRIEVTRLNGTmRKILISED------LEEPRAIVLDPMvGYMYWTDWG--EIPKIe 472
Cdd:cd05819     6 ELNNPQGIAVD-SSGNIYVADTGNNRIQVFDPDGN-FITSFGSFgsgdgqFNEPAGVAVDSD-GNLYVADTGnhRIQKF- 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 317373385  473 raalDGSDRVVLVNTSLGW-------PNGLALDyDEGKIYWGDAKTDKIEVMNTDGTGRRVL 527
Cdd:cd05819    82 ----DPDGNFLASFGGSGDgdgefngPRGIAVD-SSGNIYVADTGNHRIQKFDPDGEFLTTF 138
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 217-251 8.94e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 38.35  E-value: 8.94e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 317373385    217 QAVVKGSLPHP--FALTLFEDILYWTDWSTHSILACN 251
Cdd:smart00135    1 RTLLSSGLGHPngLAVDWIEGRLYWTDWGLDVIEVAN 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1069-1110 9.72e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 38.29  E-value: 9.72e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 317373385  1069 GYMYFTNLQERsPKIERAALDGTEREVLFFSGLSKPIALALD 1110
Cdd:pfam00058    1 GRLYWTDSSLR-ASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 671-815 9.73e-04

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 43.08  E-value: 9.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  671 VTD---NRIYWTDISLKTISRAfmnGSALEHVVEFglDYPEGMAVDWLGkNLYWADTGTNRIEVSKLDGQhrQVLVWKD- 746
Cdd:cd05819   117 VADtgnHRIQKFDPDGEFLTTF---GSGGSGPGQF--NGPTGVAVDSDG-NIYVADTGNHRIQVFDPDGN--FLTTFGSt 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  747 ------LDSPRALALDPaEGFMYWTEWGGKpKIDRAAMDGSERTTLVPNVGRAN------GLTIDyAKRRLYWTDLDTNL 814
Cdd:cd05819   189 gtgpgqFNYPTGIAVDS-DGNIYVADSGNN-RVQVFDPDGAGFGGNGNFLGSDGqfnrpsGLAVD-SDGNLYVADTGNNR 265


                  .
gi 317373385  815 I 815
Cdd:cd05819   266 I 266
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 703-816 1.02e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 43.04  E-value: 1.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  703 GLDYPEGMAVDWLGkNLYWADTGTNRIEVSKLDGqhRQVLVW-------KDLDSPRALALDPAeGFMYWTEWGGKpKIDR 775
Cdd:cd14956   152 SFNYPRGVAVDPDG-TLYVADTYNDRIQVFDNDG--AFLRKWggrgtgpGQFNYPYGIAIDPD-GNVFVADFGNN-RIQK 226

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 317373385  776 AAMDGSERTTlVPNVGRANG-------LTIDyAKRRLYWTDLDTNLIE 816
Cdd:cd14956   227 FTADGTFLTS-WGSPGTGPGqfknpwgVVVD-ADGTVYVADSNNNRVQ 272
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1114-1154 1.26e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 37.91  E-value: 1.26e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 317373385  1114 GKLFWADSDLR-RIESSDLSGANRIVLEDSNILQPVGLTVFE 1154
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 367-529 1.52e-03

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 42.25  E-value: 1.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385   367 YDPVEGYIYWTDDEVRAIRR-SFIDGSGSQFVVTAQIA----HPDGIAVDWVARNLYWTDTGTdrievtrlnGTMRKILI 441
Cdd:pfam08450    7 WDEEEGALYWVDILGGRIHRlDPATGKETVWDTPGPVGaiapRDDGGLIVALKDGVALLDLAT---------GELTPLAD 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385   442 SEDLEEPRAI----VLDP----MVGYMywtDWGEIPKIERAAL---DGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAK 510
Cdd:pfam08450   78 PEDDDWPLNRfndgKVDPdgrfWFGTM---GDDEAPGGDPGALyrlDPDGKLTRVLDGLTISNGLAWSPDGRTLYFADSP 154

                          170       180
                   ....*....|....*....|....
gi 317373385   511 TDKIEVMNTDGTG-----RRVLVE 529
Cdd:pfam08450  155 ARKIWAYDYDLDGglisnRRVFAD 178
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 667-756 1.91e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 41.89  E-value: 1.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  667 LDFDVTDNRIYWTDISLKTIsRAFMNGSalEHVVEFG--------LDYPEGMAVDWLGkNLYWADTGTNRIEVSKLDGQH 738
Cdd:cd14963    13 MGVAVSDGRIYVADTNNHRV-QVFDYEG--KFKKSFGgpgtgpgeFKYPYGIAVDSDG-NIYVADLYNGRIQVFDPDGKF 88

                          90       100
                  ....*....|....*....|..
gi 317373385  739 RQVLVWKD----LDSPRALALD 756
Cdd:cd14963    89 LKYFPEKKdrvkLISPAGLAID 110
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 665-757 2.48e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 41.54  E-value: 2.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  665 SALDFDvTDNRIYWTDISLKTISRAFMNGSALEHVVEFG-----LDYPEGMAVDWLGkNLYWADTGTNRIEVSKLDGQHr 739
Cdd:cd05819    58 AGVAVD-SDGNLYVADTGNHRIQKFDPDGNFLASFGGSGdgdgeFNGPRGIAVDSSG-NIYVADTGNHRIQKFDPDGEF- 134

                          90       100
                  ....*....|....*....|....*
gi 317373385  740 qVLVWK-------DLDSPRALALDP 757
Cdd:cd05819   135 -LTTFGsggsgpgQFNGPTGVAVDS 158
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 391-514 2.70e-03

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 41.42  E-value: 2.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  391 GSGSQFVVT-AQIAHPDGIAVDwVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPmVGYMYWTDWGEiP 469
Cdd:cd14952   123 GSNTQTVLPfTGLSNPDGVAVD-GAGNVYVTDTGNNRVLKLAAGSTTQTVLPFTGLNSPSGVAVDT-AGNVYVTDHGN-N 199

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 317373385  470 KIERAALDGSDRVVLVNTSLGWPNGLALDyDEGKIYWGDAKTDKI 514
Cdd:cd14952   200 RVLKLAAGSTTPTVLPFTGLNGPLGVAVD-AAGNVYVADRGNDRV 243
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 405-527 3.01e-03

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 41.04  E-value: 3.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  405 PDGIAVDwVARNLYWTDTGTDRieVTRLNG--TMRKILISEDLEEPRAIVLDPmVGYMYWTDWGEiPKIERAALDGSDRV 482
Cdd:cd14952    96 PTGVAVD-AAGNVYVADTGNNR--VLKLAAgsNTQTVLPFTGLSNPDGVAVDG-AGNVYVTDTGN-NRVLKLAAGSTTQT 170

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 317373385  483 VLVNTSLGWPNGLALDyDEGKIYwgdaktdkieVmnTDGTGRRVL 527
Cdd:cd14952   171 VLPFTGLNSPSGVAVD-TAGNVY----------V--TDHGNNRVL 202
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
339-427 3.47e-03

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 41.16  E-value: 3.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  339 LRRISLDTPDFTDIVLQLEDIR-HAIAIDYDpveGYIYWTDDEVRAIRRsfID---GSGSQFVVTAQIAHPDGIAVDwVA 414
Cdd:COG4257   168 IGRIDPDTGTLTEYALPTPGAGpRGLAVDPD---GNLWVADTGSGRIGR--FDpktGTVTEYPLPGGGARPYGVAVD-GD 241

                          90
                  ....*....|...
gi 317373385  415 RNLYWTDTGTDRI 427
Cdd:COG4257   242 GRVWFAESGANRI 254
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 670-757 4.06e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 41.12  E-value: 4.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  670 DVTDNRIYWTDISLKTISRAFMNGsalEHVVEFG--------LDYPEGMAVDWLGkNLYWADTGTNRIEVSKLDGQHRQV 741
Cdd:cd14963   108 AIDDGKLYVSDVKKHKVIVFDLEG---KLLLEFGkpgsepgeLSYPNGIAVDEDG-NIYVADSGNGRIQVFDKNGKFIKE 183

                          90       100
                  ....*....|....*....|.
gi 317373385  742 LVWKDLDS-----PRALALDP 757
Cdd:cd14963   184 LNGSPDGKsgfvnPRGIAVDP 204
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
642-815 4.65e-03

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 40.77  E-value: 4.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  642 IRRISLETNN-NNVAIPlTGVKEASALDFDVtDNRIYWTDISLKTISR---AfmNGSALEHVVEFGLDYPEGMAVDWLGk 717
Cdd:COG4257    82 IGRIDPKTGEiTTFALP-GGGSNPHGIAFDP-DGNLWFTDQGGNRIGRldpA--TGEVTEFPLPTGGAGPYGIAVDPDG- 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373385  718 NLYWADTGTNRI-EVSKLDGQHRQVLVWKDLDSPRALALDPaEGFMYWTEWGGKP--KIDRAamDGSERT-TLVPNVGRA 793
Cdd:COG4257   157 NLWVTDFGANAIgRIDPDTGTLTEYALPTPGAGPRGLAVDP-DGNLWVADTGSGRigRFDPK--TGTVTEyPLPGGGARP 233

                         170       180
                  ....*....|....*....|..
gi 317373385  794 NGLTIDyAKRRLYWTDLDTNLI 815
Cdd:COG4257   234 YGVAVD-GDGRVWFAESGANRI 254
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 704-770 5.27e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 40.76  E-value: 5.27e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 317373385  704 LDYPEGMAVDWLGkNLYWADTGTNRIevSKLDGQHRQVLVW-------KDLDSPRALALDPAeGFMYWTEWGGK 770
Cdd:cd05819    54 FNEPAGVAVDSDG-NLYVADTGNHRI--QKFDPDGNFLASFggsgdgdGEFNGPRGIAVDSS-GNIYVADTGNH 123
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 704-757 7.25e-03

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 40.22  E-value: 7.25e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 317373385  704 LDYPEGMAVDWLGkNLYWADTGTNRIEVSKLDGQH-----RQVLVWKDLDSPRALALDP 757
Cdd:cd14954   117 FNYPWGVAVDSEG-RIYVSDTRNHRVQVFDSDGQFirkfgFEGAGPGQLDSPRGVAVNP 174
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1015-1048 9.79e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 35.66  E-value: 9.79e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 317373385   1015 QPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSV 1048
Cdd:smart00135   10 HPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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