|
Name |
Accession |
Description |
Interval |
E-value |
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
1-730 |
0e+00 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 543.30 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 1 MEKLSRIIIKLKWIIVASVLALTIFFGYQSKFLTINSDILSSLPDDDPAASLYKTIGTQFGGNDMGMIVLES-DNVFKTE 79
Cdd:COG1033 4 MERLARFILRHRKLVLLLFLLLTLLLAYGAPKLEVDTDFESLLPEDDPSVQAYDEFEEEFGGDDTVVVAVEGkDDIFTPE 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 80 ILQHIKQITDSLRYTDGVSTVTSLTNILDIKSSEWGIEIGKLVDEhNLPNKQSQLDSLKNYVFSKEMYKGAIVSEDGTAS 159
Cdd:COG1033 84 TLEALRELTEELEEIPGVDSVTSLTNVRATEGTEDGLTVEPLIPD-ELPASPEELAELREKVLSSPLYVGRLVSPDGKAT 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 160 VVMFTLLPD-----ADKQAVAKEIKSKIKNLNLPE-TLYFGGLPMMMNDISDLILADIVWLLPIVFVIIALILLLSFKSF 233
Cdd:COG1033 163 LIVVTLDPDplssdLDRKEVVAEIRAIIAKYEDPGvEVYLTGFPVLRGDIAEAIQSDLAIFFPLALLLILLLLFLFFRSL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 234 RGVLLPLLTACIAVIWTIGIMVVTGYELTIISNIIPVVLLAVGSAYPIHVLNNINHTL--GKDRKQILIKALAYIMVPVF 311
Cdd:COG1033 243 RGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTILVPPLLLAIGIDYGIHLLNRYREERrkGLDKREALREALRKLGPPVL 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 312 LAAVTTAMGFISFVFGAyLTMIKDFGIFTAVGTLIALLLSIFFVPALISAFsmyGKKVETDQPEKENILTHKILQPIVTL 391
Cdd:COG1033 323 LTSLTTAIGFLSLLFSD-IPPIRDFGIVAAIGVLLAFLTSLTLLPALLSLL---PRPKPKTRRLKKPPELGRLLAKLARF 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 392 LFKHPKYSLTAWGILLLLSIGGMFFLKTSVNMADYFKKDNPTRISEDVMQKKFGGSLPIFVVFEGD----LQSPDVLKMM 467
Cdd:COG1033 399 VLRRPKVILVVALVLAVVSLYGISRLKVEYDFEDYLPEDSPIRQDLDFIEENFGGSDPLEVVVDTGepdgLKDPEVLKEI 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 468 IKTEHFMKNDPNIDMTQSVADLVEQMNEAMGEGKM----IPDDKAKIEQLWFL--LNGQDVMTQLVSEDLDKGIIQSRFA 541
Cdd:COG1033 479 DRLQDYLESLPEVGKVLSLADLVKELNQALNEGDPkyyaLPESRELLAQLLLLlsSPPGDDLSRFVDEDYSAARVTVRLK 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 542 SVDSKNINEFTSKMNKFIQEN-NRENIKIELTGMPSVYVKLNNSLIQSQYSSLILAIIMVLLLVGLMLRSISKGVYATIP 620
Cdd:COG1033 559 DLDSEEIKALVEEVRAFLAENfPPDGVEVTLTGSAVLFAAINESVIESQIRSLLLALLLIFLLLLLAFRSLRLGLISLIP 638
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 621 IIATIMILFGFMGITGIPLDIATVLVGSIALGIGIDYSIHFITGFNFYLKETGDAEKAIEKTILISGKAIIINVISVAAG 700
Cdd:COG1033 639 NLLPILLTFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSRYREERRKGGDLEEAIRRALRTTGKAILFTSLTLAAG 718
|
730 740 750
....*....|....*....|....*....|
gi 1082601803 701 FLVLIFSQIVPLQNFGILVALSMFGSGIGA 730
Cdd:COG1033 719 FGVLLFSSFPPLADFGLLLALGLLVALLAA 748
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
15-730 |
1.55e-72 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 250.52 E-value: 1.55e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 15 IVASVLALTIFFGYQSKFLTINSDILSSLPDDDPAASLYKTIGTQFG-GNDMGMIVLESDNVFKTEILQHIKQITDSLRY 93
Cdd:TIGR00921 7 IILVFLALLILSAYGAQHLNVESDTEKQLPKDFESYKWYHVLQREFGtSTKTLLVVIEGDDVTRKPVLDYMRRLEQRLRE 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 94 TDGVSTVTSLTNILdiKSSEWGIEigklvdehnLPNKQSQLDSLKNyvfSKEMYKGAIVSEDGTASVVMFTLLPDADKQA 173
Cdd:TIGR00921 87 KPYVTNVRSAADIM--RQIPGNFP---------LPVTMPEVRPLMS---EYPRSKEMFLSKDHTVAIIIVQLKSDADYKQ 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 174 ---VAKEIKSKIKNLNLPETLY--FGGLPMMMNDISDLILADIVWLLPIVFVIIALILLLSFKSFRGVLLPLLTACIAVI 248
Cdd:TIGR00921 153 vvpIYNDVERSLERTNPPSGKFldVTGSPAINYDIEREFGKDMGTTMAISGILVVLVLLLDFKRWWRPLLPLVIILFGVA 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 249 WTIGIMVVTGYELTIISNIIPVVLLAVGSAYPIHVLNNINHTL--GKDRKQILIKALAYIMVPVFLAAVTTAMGFISfVF 326
Cdd:TIGR00921 233 WVLGIMGWLGIPLYATTLLAVPMLIGVGIDYGIQTLNRYEEERdiGRAKGEAIVTAVRRTGRAVLIALLTTSAGFAA-LA 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 327 GAYLTMIKDFGIFTAVGTLIALLLSIFFVPALISAFSMYGKKVEtdqpeKENILT-------HKILQPIVTLLFKHPKYS 399
Cdd:TIGR00921 312 LSEFPMVSEFGLGLVAGLITAYLLTLLVLPALLQSIDIGREKVK-----KEIIAIggksseiEEELSKVLSITVRHPVPA 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 400 LTAWGILLLLSIGGMFFLKTSVNMADYFKKDNPTRISEDVMQKKFGGSLP--IFVVFEGDLQSPDVLKMMIKTEHFMKND 477
Cdd:TIGR00921 387 LVAALIITGLGLYGAAGIKPEVNIEKFIPQDLPSLQARKVIESHMGGSHDfaTILVKADDVRDPELVRFMDELSRDIKAT 466
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 478 ---PNIDMTQSVADLVEQMNEAMGEGKMIPDDKAKIEqlwfllngqdvmtqlVSEDLDKGIIQSRFASVDSKnINEFTSK 554
Cdd:TIGR00921 467 gvaARVFGAPSIIDLVKEVEGLPAPERSALEPIPEDE---------------EGGYISGGQIKVAVIQVQLK-QGEPKVQ 530
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 555 MNKFIQENNREN----IKIELTGMPSVYVKLNNSLIQSQYSSLILAIIMVLLLVGLMLRSISKGVYATIPIIATIMILFG 630
Cdd:TIGR00921 531 GRKILRDVQHEHpppgVKVGVTGLPVAFAEMHELVNEGMRRMTIAGAILVLMILLAVFRNPIKAVFPLIAIGSGILWAIG 610
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 631 FMGITGIPLDIATVLVGSIALGIGIDYSIHFITGFNFYLKETGDAEkAIEKTILISGKAIIINVISVAAGFLVLIFSQIV 710
Cdd:TIGR00921 611 LMGLRGIPSFLAMATTISIILGLGMDYSIHLAERYFEERKEHGPKE-AITHTMERTGPGILFSGLTTAGGFLSLLLSHFP 689
|
730 740
....*....|....*....|
gi 1082601803 711 PLQNFGILVALSMFGSGIGA 730
Cdd:TIGR00921 690 IMRNFGLVQGIGVLSSLTAA 709
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
1-370 |
3.35e-46 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 176.59 E-value: 3.35e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 1 MEKLSRIIIKLKWIIVASVLALTIFFGYQSKFLTINSDILSSLPDDDPAASLYKTIGTQFGGNDMGMIVLES---DNVFK 77
Cdd:COG1033 392 LAKLARFVLRRPKVILVVALVLAVVSLYGISRLKVEYDFEDYLPEDSPIRQDLDFIEENFGGSDPLEVVVDTgepDGLKD 471
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 78 TEILQHIKQITDSLRYTDGVSTVTSLTNIldIKSSEWGIEIGKLvDEHNLPNKQSQLDSLKNYVFS-KEMYKGAIVSEDG 156
Cdd:COG1033 472 PEVLKEIDRLQDYLESLPEVGKVLSLADL--VKELNQALNEGDP-KYYALPESRELLAQLLLLLSSpPGDDLSRFVDEDY 548
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 157 TASVVMFTL--LPDADKQAVAKEIKSKIKNLNLPETL--YFGGLPMMMNDISDLILADIVWLLPIVFVIIALILLLSFKS 232
Cdd:COG1033 549 SAARVTVRLkdLDSEEIKALVEEVRAFLAENFPPDGVevTLTGSAVLFAAINESVIESQIRSLLLALLLIFLLLLLAFRS 628
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 233 FRGVLLPLLTACIAVIWTIGIMVVTGYELTIISNIIPVVLLAVGSAYPIHVLNNINHTL--GKDRKQILIKALAYIMVPV 310
Cdd:COG1033 629 LRLGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSRYREERrkGGDLEEAIRRALRTTGKAI 708
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 311 FLAAVTTAMGFISFVFgAYLTMIKDFGIFTAVGTLIALLLSIFFVPALISAFSMYGKKVE 370
Cdd:COG1033 709 LFTSLTLAAGFGVLLF-SSFPPLADFGLLLALGLLVALLAALLLLPALLLLLDPRIAKKR 767
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
382-724 |
7.76e-46 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 175.43 E-value: 7.76e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 382 HKILQPIVTLLFKHPKYSLTAWGILLLLSIGGMFFLKTSVNMADYFKKDNPTRISEDVMQKKFGGSLPIFVVFEG--DLQ 459
Cdd:COG1033 1 ERLMERLARFILRHRKLVLLLFLLLTLLLAYGAPKLEVDTDFESLLPEDDPSVQAYDEFEEEFGGDDTVVVAVEGkdDIF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 460 SPDVLKMMIKTEHFMKNDPNIDMTQSVADLVEQMNEAMGE------GKMIPDDKAKIEQLW-FLLNGQDVMTQLVSEDLD 532
Cdd:COG1033 81 TPETLEALRELTEELEEIPGVDSVTSLTNVRATEGTEDGLtvepliPDELPASPEELAELReKVLSSPLYVGRLVSPDGK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 533 KGIIQSRFASV---DSKNINEFTSKMNKFIQENNRENIKIELTGMPSVYVKLNNSLIQSQYSSLILAIIMVLLLVGLMLR 609
Cdd:COG1033 161 ATLIVVTLDPDplsSDLDRKEVVAEIRAIIAKYEDPGVEVYLTGFPVLRGDIAEAIQSDLAIFFPLALLLILLLLFLFFR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 610 SISKGVYATIPIIATIMILFGFMGITGIPLDIATVLVGSIALGIGIDYSIHFITGFNFYLKETGDAEKAIEKTILISGKA 689
Cdd:COG1033 241 SLRGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTILVPPLLLAIGIDYGIHLLNRYREERRKGLDKREALREALRKLGPP 320
|
330 340 350
....*....|....*....|....*....|....*
gi 1082601803 690 IIINVISVAAGFLVLIFSQIVPLQNFGILVALSMF 724
Cdd:COG1033 321 VLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVL 355
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
8-721 |
1.49e-31 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 131.43 E-value: 1.49e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 8 IIKLKWIIVASVLALTIFFG-YQSKFLTINSDILSSLPDDDPAASLyKTIGTQFGGNDMG--MIVLESDN--VFKTEILQ 82
Cdd:COG2409 1 VARHRWLVLLAWLVLLVALGvLAPQLGGSLSSNGFFLPGSESQRAA-DLLAEAFPESDGAsaVVVVEAPDgtLTDPAFRA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 83 HIKQITDSLRYTDGVSTVTSLTNILDikssewgieigklvdehnlpnkqsqldslknyvfskemykGAIVSEDGTASVVM 162
Cdd:COG2409 80 AVAALVARLRADPGVAGVQDPWDDPA----------------------------------------AGLVSEDGKAALVT 119
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 163 FTLLPDAD--KQAVAKEIKSKIKNLNLPE-TLYFGGLPMMMNDISDLILADIVWLLPIVFVIIALILLLSFKSFRGVLLP 239
Cdd:COG2409 120 VTLDGDAGdeAAEAVDALRDAVAAAPAPGlTVYVTGPAALAADLNEAFEEDLGRAELITLPVALVVLLLVFRSLVAALLP 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 240 LLTACIAVIWTIGIMVVTGYELTI---ISNIIPVVLLAVGSAYPIHVLN----NINHtlGKDRKQILIKALAYIMVPVFL 312
Cdd:COG2409 200 LLTAGLAVGVALGLLALLAAFTDVssfAPNLLTMLGLGVGIDYALFLVSryreELRA--GEDREEAVARAVATAGRAVLF 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 313 AAVTTAMGFIS-FVFGayLTMIKDFGIFTAVGTLIALLLSIFFVPALISAFsmyGKKVE---TDQPEKENILTHKILQPI 388
Cdd:COG2409 278 SGLTVAIALLGlLLAG--LPFLRSMGPAAAIGVAVAVLAALTLLPALLALL---GRRVFwprRPRRRRAAAPESGFWRRL 352
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 389 VTLLFKHPKYSLTAWGILLLLSIGGMFFLKTSVNMADYFKKDNPTRISEDVMQKKFGGSL--PIFVVFEGD-LQSPDVLK 465
Cdd:COG2409 353 ARAVVRRPVPVLVAAVAVLLALALPALGLRLGLPDADSLPADSPSRQGYDALAEHFPPGSngPLTVVVESDdDLDPADLA 432
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 466 MMIKTEHFMKNDPNIDMTQSVADLVeqmnEAMGEGKMI-------PDDKAkieqlwfllnGQDVMTQLVSEDLDKgiiqs 538
Cdd:COG2409 433 ALDALAAALAAVPGVASVQPPTRPE----GTDGDAARLqvvpdgdPDSPE----------AIDLVDRLRDAAAPA----- 493
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 539 rfasvdsknineftskmnkfiqennRENIKIELTGMPSVYVKLNNSLIQSQYSSLILAIIMVLLLVGLMLRSIskgvyaT 618
Cdd:COG2409 494 -------------------------LEGAEVLVGGTTAVNIDISDALADDLPLVIPVVLGLIFLLLLLLFRSV------V 542
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 619 IPIIATIMILFGF-----------------MGITGIPLDIAT-VLVGSIALGIGIDYSIHFITGFNFYLKETGDAEKAIE 680
Cdd:COG2409 543 APLKAVLTNLLSLgaalgvlvlvfqhgwllLGFTPGPLDSFVpLLLFVILFGLGMDYEVFLVSRIREEYDRGGGTREAVI 622
|
730 740 750 760
....*....|....*....|....*....|....*....|....*..
gi 1082601803 681 KTILISGKAIiinvisVAAG------FLVLIFSQIVPLQNFGILVAL 721
Cdd:COG2409 623 RGLARTGRVI------TSAAlimaavFAAFATSPLVFLKQIGFGLAV 663
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
145-724 |
5.32e-26 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 114.18 E-value: 5.32e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 145 EMYKGAIVSEDGTASVVMFTL-----LPDADKQAVA--KEIKSKIKNLNL-PETLYFGGLPMMmNDISDLILADIVWLLP 216
Cdd:COG4258 178 RLRDGVLVSRDGTWALLLAETrasgfDTDAQQQLVAalRAAFAALNAAFPgAQLLLTGAGLFA-VAAAQQIKHDISTIGL 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 217 IVFVIIALILLLSFKSFRGVLLPLLTACIAVIWTIGIMVVTGYELTIISNIIPVVLLAVGSAYPIHVLNNINHTLGKDRK 296
Cdd:COG4258 257 ISLLGILLLLLLVFRSLRPLLLGLLPVAVGALAGLAAVSLVFGSVHGITLGFGSSLIGVAVDYSLHYLTHRRAAGEWDPR 336
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 297 QilikALAYIMVPVFLAAVTTAMGFISFVFgAYLTMIKDFGIFTAVGTLIALLLSIFFVPALISAfsmygkkvetdQPEK 376
Cdd:COG4258 337 A----ALRRIWPTLLLGLLTTVLGYLALLF-SPFPGLRQLGVFAAAGLLAAALTTLLWLPLLLPR-----------AAPR 400
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 377 ENILTHKILQPIVTLLFKHPKYSLTAWGILLLLSIGGMFFLKTSVNMADYFKKDNPTRISEDVMQKKFGGSLP-IFVVFE 455
Cdd:COG4258 401 PPAPALALLARLLARWPRRLRWLLALLAVLALASLLGLNRLKWNDDLRALNPVPAALLAQEARLRALLGAPDVsQYLVVY 480
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 456 GD-----LQSPDVLKMMIKTehfMKNDPNIDMTQSVADLV--------------------EQMNEAMGEGKMIPDDKAKI 510
Cdd:COG4258 481 GPdaeqaLQRNEALLPRLDA---LVAQGAIAGYQSLSRLLpsaatqqarqallpdlaalrPRLAEALAGLGFRPDAFAPF 557
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 511 EQLWFLLNGQDVMTQlvsEDLDKGIIQSRFAS--VDSKNiNEFTS-----KMnkfiqeNNRENIKIELTGMPSVYV---- 579
Cdd:COG4258 558 LADLEAARAAPPLTP---EDLLASPLAAALRLllLGRKD-GQWAAlvplrGV------DDAAALRAAAAGLPGVRLvdrk 627
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 580 KLNNSLIqSQYSS-----LILAIIMVLLLVGLMLRSISKGVYATIPIIATIMILFGFMGITGIPLDIATVLVGSIALGIG 654
Cdd:COG4258 628 AESSSLF-GRYRNdalwlLLLALLLILLLLLLRLRSLRRALRVLLPPLLAVLLTLAILGLLGIPLNLFHLIALLLVLGIG 706
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 655 IDYSIhFITgfnfylkeTGDAEKAIEKTILISgkaIIINVISVAAGFLVLIFSQIVPLQNFGILVALSMF 724
Cdd:COG4258 707 IDYAL-FFT--------EGLLDKGELARTLLS---ILLAALTTLLGFGLLAFSSTPALRSFGLTVLLGIL 764
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
3-359 |
4.90e-22 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 101.45 E-value: 4.90e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 3 KLSRIIIKLKWIIVASVLALTIFFGYQSKFLTINSDILSSLPDDDPAASLYKTIGTQFGG-NDMGMIVLESDNVFKTEIL 81
Cdd:TIGR00921 374 KVLSITVRHPVPALVAALIITGLGLYGAAGIKPEVNIEKFIPQDLPSLQARKVIESHMGGsHDFATILVKADDVRDPELV 453
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 82 QHIKQITDSLRYTDGVSTVTSLTNILDIKSSEWGIeigklvdehnLPNKQSQLDSLknyvfSKEMYKGAIVSEDGTASVV 161
Cdd:TIGR00921 454 RFMDELSRDIKATGVAARVFGAPSIIDLVKEVEGL----------PAPERSALEPI-----PEDEEGGYISGGQIKVAVI 518
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 162 MFTLLPDaDKQAVAKEIKSKIKNLNLP--ETLYFGGLPMMMNDISDLILADIVWLLPIVFVIIALILLLSFKSFRGVLLP 239
Cdd:TIGR00921 519 QVQLKQG-EPKVQGRKILRDVQHEHPPpgVKVGVTGLPVAFAEMHELVNEGMRRMTIAGAILVLMILLAVFRNPIKAVFP 597
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 240 LLTACIAVIWTIGIMVVTGYELTIISNIIPVVLLAVGSAYPIHVLNNINHTLGKDR-KQILIKALAYIMVPVFLAAVTTA 318
Cdd:TIGR00921 598 LIAIGSGILWAIGLMGLRGIPSFLAMATTISIILGLGMDYSIHLAERYFEERKEHGpKEAITHTMERTGPGILFSGLTTA 677
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1082601803 319 MGFISFVFgAYLTMIKDFGIFTAVGTLIALLLSIFFVPALI 359
Cdd:TIGR00921 678 GGFLSLLL-SHFPIMRNFGLVQGIGVLSSLTAALVVFPALL 717
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
215-723 |
7.78e-20 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 94.68 E-value: 7.78e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 215 LPIVFVIIALILLLSFKSFRGVLLPLLTACIAVIWTIGIMVVTGYELTIISNIIPVVLLAVGSAYPIHVL----NNINht 290
Cdd:TIGR03480 275 GLLSFVLVLVLLWLALRSPRLVFAVLVTLIVGLILTAAFATLAVGHLNLISVAFAVLFIGLGVDFAIQFSlryrEERF-- 352
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 291 LGKDRKQILIKALAYIMVPVFLAAVTTAMGFISFVFGAYLTmIKDFGIFTAVGTLIALLLSIFFVPALISAFSMYGKKVE 370
Cdd:TIGR03480 353 RGGNHREALSVAARRMGAALLLAALATAAGFFAFLPTDYKG-VSELGIIAGTGMFIALFVTLTVLPALLRLLRPPRRRKP 431
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 371 TDQPEkenilthkiLQPIVTLLFKHPKYSLtawGILLLLSIGGMFFLK------------------------------TS 420
Cdd:TIGR03480 432 PGYAT---------LAPLDAFLRRHRRPVL---GVTLILGIAALALLPqlrfdfnplnlqdpktesvrtflelladpdTS 499
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 421 VN------------------------------MADYFKKDNPTRIS------------------------EDVMQ--KKF 444
Cdd:TIGR03480 500 PYsaevlapsapearalterlealpevdqvvtLPDFVPDDQEAKLAliadlalvlgptlnpgeadpapsaEEVAAalRRL 579
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 445 GGSLPIFVVFEGDLQSPDVLKMMIKTEHFMKNDPNidmtqsVADLVEQMNEAMGEGkmIPDdkaKIEQLWFLLNGQDVMT 524
Cdd:TIGR03480 580 AARLRAAAAKSQDPDAAAAGRLAASLDRLLAKAPA------QAATLRALQGALLAG--LPG---ELDRLRDSLQAEPVTL 648
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 525 QLVSEDLDKGII----QSRFASVDSKNINEfTSKMNKFIQEnnRENIKIELTGMPSVYVKLNNSLIQSQYSSLILAIIMV 600
Cdd:TIGR03480 649 EDLPPDLRRRWVakdgRARLEVFPKEDLND-NEALRRFVRA--VRKVAPDATGAPVSILESGDTVVGAFLQAFIYALVAI 725
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 601 LLLVGLMLRSISKGVYATIPIIATIMILFGFMGITGIPLDIATVLVGSIALGIGIDYSIHFITGFnfylketgdaEKAIE 680
Cdd:TIGR03480 726 TVLLLLTLRRVRDVLLVLAPLLLAGLLTVAAMVLLGIPFNFANIIALPLLLGLGVDFGIYMVHRW----------RNGVD 795
|
570 580 590 600
....*....|....*....|....*....|....*....|....*.
gi 1082601803 681 KTILIS---GKAIIINVISVAAGFLVLIFSQIVPLQNFGILVALSM 723
Cdd:TIGR03480 796 SGNLLQsstARAVFFSALTTATAFGSLAVSSHPGTASMGILLSLGL 841
|
|
| actII |
TIGR00833 |
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ... |
145-485 |
1.10e-19 |
|
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 129913 [Multi-domain] Cd Length: 910 Bit Score: 94.27 E-value: 1.10e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 145 EMYKGAIvSEDGTASVVMFTLLPDADK---QAVAKEIKSKIKNLNLPE--TLYFGGLPMMMNDISDLILADIVWLLPIVF 219
Cdd:TIGR00833 105 EAAEGLR-SDDGKATIIIVNLAGEKGQkeaQEAINAVRRIVEQTNAPDglTVHVTGPLATIADILESGDKDMNRITATTG 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 220 VIIALILLLSFKSFRGVLLPLLTACIAVIWTIGIMVVTGYELTIISN-----IIPVVLLAVGSAYPIHVLNNINHTL--G 292
Cdd:TIGR00833 184 IIVLIILLLVYRSPITMLVPLVSVGFSVVVAQGIVSLLGIPGLIGVNaqttvLLTALVIGAGTDYAVFLTGRYHEERrkG 263
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 293 KDRKQILIKALAYIMVPVFLAAVTTAMGFISFVFgAYLTMIKDFGIFTAVGTLIALLLSIFFVPALISAFSMYGKkvetd 372
Cdd:TIGR00833 264 ESLEEAAAEALRGTGKAILGSALTVAVAFLALSL-ARLPSFKTLGVSCAVGVLVALLNAVTLTPALLTLEGREGL----- 337
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 373 QPEKENILTHKILQPIVTLLFKHPKYSLTAWGILLLLSIGGMFFLKTSVNMADYFKKDNPTRISEDVMQKKFGGS--LPI 450
Cdd:TIGR00833 338 MKPGRKSKIRFIWRRLGTAVVRRPWPILVTTLIISGVSLLALPLIRTGYDDEKMIPTDLESVQGYEAADRHFPGNsmDPM 417
|
330 340 350
....*....|....*....|....*....|....*..
gi 1082601803 451 FVVFEG--DLQSPDVLKMMIKTEHFMKNDPNIDMTQS 485
Cdd:TIGR00833 418 VVMIKSdhDVRNPALLADIDRFEREIKAVPGINMVQE 454
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
3-358 |
1.45e-17 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 87.13 E-value: 1.45e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 3 KLSRIIIKLKWIIVASVLALTIFFGYQSKFLTINSDILSSLPDDDPAASLYKTIGTQFGGNDMG--MIVLESDNVFKTEI 80
Cdd:COG2409 351 RLARAVVRRPVPVLVAAVAVLLALALPALGLRLGLPDADSLPADSPSRQGYDALAEHFPPGSNGplTVVVESDDDLDPAD 430
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 81 LQHIKQITDSLRYTDGVSTVTSLTNILdikssewgieigklvdehnlpnkqsqldslknyvfskemykgaivSEDGTASV 160
Cdd:COG2409 431 LAALDALAAALAAVPGVASVQPPTRPE---------------------------------------------GTDGDAAR 465
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 161 VMFTL--LPDADK-QAVAKEIKSKIKNLNLPETLYFGGLPMMMNDISDLILADIVWLLPIVFVIIALILLLSFKSfrgVL 237
Cdd:COG2409 466 LQVVPdgDPDSPEaIDLVDRLRDAAAPALEGAEVLVGGTTAVNIDISDALADDLPLVIPVVLGLIFLLLLLLFRS---VV 542
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 238 LPL-LTACIA--VIWTIGIMV--------VTGYELTIISNIIP----VVLLAVGSAYPIHVLNNI--NHTLGKDRKQILI 300
Cdd:COG2409 543 APLkAVLTNLlsLGAALGVLVlvfqhgwlLLGFTPGPLDSFVPlllfVILFGLGMDYEVFLVSRIreEYDRGGGTREAVI 622
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1082601803 301 KALAY----------IMvpvflAAVTTAMGFISfvfgayLTMIKDFGIFTAVGTLI-ALLLSIFFVPAL 358
Cdd:COG2409 623 RGLARtgrvitsaalIM-----AAVFAAFATSP------LVFLKQIGFGLAVGVLLdAFVVRMLLVPAL 680
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
120-363 |
1.72e-17 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 84.27 E-value: 1.72e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 120 KLVDEhnLPNKQSQLDSLKNYVFSKEMYKGAiVSEDGTASVVMFTLLPDAD---KQAVAKEIKSKIKNLNLPETL--YFG 194
Cdd:pfam03176 51 TLVDA--LRADTGHVGSVQDFWGDPDTAALF-VSPDGKAAYVVVTLEGDPGtteADESVAAVRDAVEQAPPPEGLkaYLT 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 195 GLPMMMNDISDLILADIVWLLPIVFVIIALILLLSFKSFRGVLLPLLTACIAVIWTIGIMVVTGYEL-----TIISNIIP 269
Cdd:pfam03176 128 GPAATVADLRDAGDRDLGLIEAVTLVVIFIILLIVYRSVVAALLPLLTVGLSLGAAQGLVAILAHILgiglsTFALNLLV 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 270 VVLLAVGSAYPIHVLNNINHTL--GKDRKQILIKALAYIMVPVFLAAVTTAMGFISFVFgAYLTMIKDFGIFTAVGTLIA 347
Cdd:pfam03176 208 VLLIAVGTDYALFLVSRYREELraGEDREEAVIRAVRGTGKVVTAAGLTVAIAMLALSF-ARLPVFAQVGPTIAIGVLVD 286
|
250
....*....|....*.
gi 1082601803 348 LLLSIFFVPALISAFS 363
Cdd:pfam03176 287 VLAALTLLPALLALLG 302
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
153-357 |
5.68e-17 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 85.29 E-value: 5.68e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 153 SEDGTASVVmfTLLPDADKQAVAKEIKskiknlNLPETLYFGgLPMMMNDISDLILADIVWLLPIVFVIIALILLLSFKS 232
Cdd:COG4258 592 KDGQWAALV--PLRGVDDAAALRAAAA------GLPGVRLVD-RKAESSSLFGRYRNDALWLLLLALLLILLLLLLRLRS 662
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 233 FRGVLLPLLTACIAVIWTIGIMVVTGYELTIISNIIPVVLLAVGSAYPIHVLNNINHTlgkdrkqiliKALAYIMVPVFL 312
Cdd:COG4258 663 LRRALRVLLPPLLAVLLTLAILGLLGIPLNLFHLIALLLVLGIGIDYALFFTEGLLDK----------GELARTLLSILL 732
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1082601803 313 AAVTTAMGFISFVFgAYLTMIKDFGIFTAVGTLIALLLSIFFVPA 357
Cdd:COG4258 733 AALTTLLGFGLLAF-SSTPALRSFGLTVLLGILLALLLAPLLAPR 776
|
|
| AcrB |
COG0841 |
Multidrug efflux pump subunit AcrB [Defense mechanisms]; |
151-420 |
7.10e-13 |
|
Multidrug efflux pump subunit AcrB [Defense mechanisms];
Pssm-ID: 440603 [Multi-domain] Cd Length: 1015 Bit Score: 72.44 E-value: 7.10e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 151 IVSEDGTASVVM-FTLLPDADKQAVAKEIKSKIKNLN--LPETLYFGglpmMMNDISDLI---LADIVWLLPIVFVIIAL 224
Cdd:COG0841 271 IARLNGKPAVGLaIQKQPGANALEVADAVRAKLEELQasLPEGVELT----IVYDQSEFIrasIEEVVKTLLEAILLVVL 346
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 225 ILLLSFKSFRGVLLPLLTACIAVIWTIGIMVVTGYELTIISniipvvL----LAVG----SAypIHVLNNINHTL--GKD 294
Cdd:COG0841 347 VVFLFLRSWRATLIPAVAIPVSLIGTFAVMYLLGFSLNILT------LfalvLAIGivvdDA--IVVVENIERHMeeGLS 418
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 295 RKQILIKALAYIMVPVFLAAVTTA-----MGFISFVFGAyltMIKDFGIFTAVGTLIALLLSIFFVPALISAFsmyGKKV 369
Cdd:COG0841 419 PLEAAIKGAREVAGAVIASTLTLVavflpLAFMGGITGQ---LFRQFALTVAIALLISLFVALTLTPALCARL---LKPH 492
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1082601803 370 ETDQPEKENILTHKIL-------QPIVTLLFKHPKYSLTAWGILLLLSIGGMFFLKTS 420
Cdd:COG0841 493 PKGKKGRFFRAFNRGFdrltrgyGRLLRWALRHRKLTLLVALALLALSVLLFGRLPTE 550
|
|
| actII |
TIGR00833 |
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ... |
188-358 |
1.01e-12 |
|
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 129913 [Multi-domain] Cd Length: 910 Bit Score: 71.92 E-value: 1.01e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 188 PETLYFGGLPMMMNDISDLILADIVWLLPIVFVIIALILLLSFKSFRGVLLPLLTACIAVIWTIGIMV-----VTGYEL- 261
Cdd:TIGR00833 723 PAKVELAGVSAVNRDLRDLVNSDLGLISIITLAIVFMILALLLRAPVAPIVLIGSVALSYLWALGLSVlafqhILGAELh 802
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 262 TIISNIIPVVLLAVGSAYPIHVLNNINHTLGKDRKQILIKALAYIMVPVFLAAVTTAMGFISFVfGAYLTMIKDFGIFTA 341
Cdd:TIGR00833 803 WSVLAGVFVLLVALGVDYNMLLVSRIKEESPAGNRTGIIRALGSTGGVITAAGLVFAGTMAALA-SAQLTAIAQFGFTVG 881
|
170
....*....|....*...
gi 1082601803 342 VGTLI-ALLLSIFFVPAL 358
Cdd:TIGR00833 882 VGILLdTFIVRSVTVPAL 899
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
393-733 |
1.61e-12 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 70.95 E-value: 1.61e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 393 FKHPKYSLTAWGILLLLSIGGMFFLKTSVNMADYFKKDNPTRISEDVMQKKFGG--SLPIFVVFE---GDLQSPDVLkmm 467
Cdd:COG2409 2 ARHRWLVLLAWLVLLVALGVLAPQLGGSLSSNGFFLPGSESQRAADLLAEAFPEsdGASAVVVVEapdGTLTDPAFR--- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 468 iktehfmkndpnidmtQSVADLVEQMNEAmgegkmipDDKAKIEQLWfllngQDVMTQLVSEDLDKGIIQSRFASVDSKN 547
Cdd:COG2409 79 ----------------AAVAALVARLRAD--------PGVAGVQDPW-----DDPAAGLVSEDGKAALVTVTLDGDAGDE 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 548 INEFTSKMNKFIQENNRENIKIELTGMPSVYVKLNNSLIQSQYSSLILAIIMVLLLVGLMLRSIskgVYATIPIIATIMI 627
Cdd:COG2409 130 AAEAVDALRDAVAAAPAPGLTVYVTGPAALAADLNEAFEEDLGRAELITLPVALVVLLLVFRSL---VAALLPLLTAGLA 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 628 LFGFMGITG-----IPLDI-ATVLVGSIALGIGIDYSIHFITGFNFYLKETGDAEKAIEKTILISGKAIIINVISVAAGF 701
Cdd:COG2409 207 VGVALGLLAllaafTDVSSfAPNLLTMLGLGVGIDYALFLVSRYREELRAGEDREEAVARAVATAGRAVLFSGLTVAIAL 286
|
330 340 350
....*....|....*....|....*....|..
gi 1082601803 702 LVLIFSQIVPLQNFGILVALSMFGSGIGAITL 733
Cdd:COG2409 287 LGLLLAGLPFLRSMGPAAAIGVAVAVLAALTL 318
|
|
| actII |
TIGR00833 |
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ... |
526-743 |
1.35e-09 |
|
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 129913 [Multi-domain] Cd Length: 910 Bit Score: 61.52 E-value: 1.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 526 LVSEDLDKGIIQSRFA-SVDSKNINE-FTSKMNKFIQENNRENIKIELTGMPSVYVKLNNSLIQSQYSSLILAIIMVLLL 603
Cdd:TIGR00833 110 LRSDDGKATIIIVNLAgEKGQKEAQEaINAVRRIVEQTNAPDGLTVHVTGPLATIADILESGDKDMNRITATTGIIVLII 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 604 VGLMLRSISKGVYATIPIIATIMILFGFMGITGIPLDI-----ATVLVGSIALGIGIDYSIHFITGFNFYLKETGDAEKA 678
Cdd:TIGR00833 190 LLLVYRSPITMLVPLVSVGFSVVVAQGIVSLLGIPGLIgvnaqTTVLLTALVIGAGTDYAVFLTGRYHEERRKGESLEEA 269
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1082601803 679 IEKTILISGKAIIINVISVAAGFLVLIFSQIVPLQNFGILVALSMFGSGIGAITLLPIILILANR 743
Cdd:TIGR00833 270 AAEALRGTGKAILGSALTVAVAFLALSLARLPSFKTLGVSCAVGVLVALLNAVTLTPALLTLEGR 334
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
195-359 |
2.79e-09 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 60.78 E-value: 2.79e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 195 GLPMMMNDISDLILADIVWLLPIVFVIIALILLLSFKSFRGVLLPLLTACIAVIWTIGIMVVTGYELTiISNIIPV-VLL 273
Cdd:TIGR03480 698 GAPVSILESGDTVVGAFLQAFIYALVAITVLLLLTLRRVRDVLLVLAPLLLAGLLTVAAMVLLGIPFN-FANIIALpLLL 776
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 274 AVGSAYPIHVLNNINHtlGKDRKQILIKALAYimvPVFLAAVTTAMGFISFVFGAYLTMiKDFGIFTAVGTLIALLLSIF 353
Cdd:TIGR03480 777 GLGVDFGIYMVHRWRN--GVDSGNLLQSSTAR---AVFFSALTTATAFGSLAVSSHPGT-ASMGILLSLGLGLTLLCTLI 850
|
....*.
gi 1082601803 354 FVPALI 359
Cdd:TIGR03480 851 FLPALL 856
|
|
| CusA |
COG3696 |
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism]; |
151-420 |
1.18e-08 |
|
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
Pssm-ID: 442911 [Multi-domain] Cd Length: 1031 Bit Score: 58.89 E-value: 1.18e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 151 IVSEDGTASVVMFT--LLPDADKQAVAKEIKSKIKNLN--LPE-----TLYfgglpmmmnDISDLILADI--VW---LLP 216
Cdd:COG3696 274 AATLNGEGEVVGGIvlMLKGENALEVIEAVKAKLAELKpsLPEgvkivPFY---------DRSDLIDRAIhtVTknlLEG 344
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 217 IVFVIIALILLLSfkSFRGVLLPLLTACIAVIWTIGIMVVTGyeltIISNIIPVVLLA------VGSAypIHVLNNINHT 290
Cdd:COG3696 345 ALLVILVLFLFLG--NLRAALIVALAIPLSLLFAFIVMRLFG----ISANLMSLGGLAidfgiiVDGA--VVMVENILRR 416
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 291 L--------GKDRKQILIKALAYIMVPVFLAAVTTAMGFISfvfgayltmikdfgIFTAVGT----------------LI 346
Cdd:COG3696 417 LeenraagtPRERLEVVLEAAREVRRPIFFATLIIILVFLP--------------IFTLEGVegklfrpmaltvifalLG 482
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1082601803 347 ALLLSIFFVPALISAFsmYGKKVetdqPEKENILT---HKILQPIVTLLFKHPKYSLTAWGILLLLSIGGMFFLKTS 420
Cdd:COG3696 483 ALLLSLTLVPVLASLL--LRGKV----PEKENPLVrwlKRLYRPLLRWALRHPKLVLAVALVLLVLALALFPRLGSE 553
|
|
| ACR_tran |
pfam00873 |
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ... |
143-420 |
2.52e-07 |
|
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.
Pssm-ID: 395701 [Multi-domain] Cd Length: 1021 Bit Score: 54.22 E-value: 2.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 143 SKEMYKGAIVSEDGTASVVMFTLLPDADKQAVAKEIKSKIKNLN--LPE-----TLYfgglpmmmnDISDLI---LADIV 212
Cdd:pfam00873 264 GSELYRGFATFNGKPAVGLGVQKLPGANAIETADAVRAKLAELKptFPQgveivVVY---------DTTPFIrasIEEVV 334
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 213 WLLPIVFVIIALILLLSFKSFRGVLLPLLTACIAVIWTIGIMVVTGYELTIISniIPVVLLAVGSAY--PIHVLNNINHT 290
Cdd:pfam00873 335 KTLLEAIVLVILVMFLFLQNWRATLIPAIAIPLSLLGTFAVMKAFGFSINTLT--LGGLVLAIGLVVddAIVVVENIERV 412
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 291 L---GKDRKQILIKALAYIMVP-VFLAAVTTA----MGFISFVFGAyltMIKDFGIFTAVGTLIALLLSIFFVPALISAF 362
Cdd:pfam00873 413 LeenGLKPLEAAYKSMGEIGGAlVAIALVLSAvflpILFLGGLTGR---IFRQFAITIVLAILLSVLVALTLTPALCATL 489
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1082601803 363 SMYGKKVETDQPEKE-NILTHKILQ---PIVTLLFKHPKYSLTAWGILLLLSIGGMFFLKTS 420
Cdd:pfam00873 490 LKPRREPKHGGFFRWfNRMFDRLTRgyaKLLAKVLRHTAVVLLVALLLVVGSVWLFVRIPTE 551
|
|
| RND_permease_2 |
NF033617 |
multidrug efflux RND transporter permease subunit; |
150-360 |
2.84e-07 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 411236 [Multi-domain] Cd Length: 1009 Bit Score: 54.25 E-value: 2.84e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 150 AIVSEDGTASVVM-FTLLPDADKQAVAKEIKSKIKNL--NLPETLYFGglpmMMNDISDLILA---DIVWLLPIVFVIIA 223
Cdd:NF033617 269 NRAWANGVPAVVLgINRQPGANPIEVADEIRALLPELqeTLPKNIKVN----VLYDRTRFIRAsidEVESTLLEAVALVI 344
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 224 LILLLSFKSFRGVLLPLLTACIAVIWTIGIMVVTGYE---LTIISNIIPVVLLaVGSAypIHVLNNINHTL--GKDRKQI 298
Cdd:NF033617 345 LVVFLFLRNLRATLIPAVTVPLSLIGTFAVMYLFGFSinlLTLMALVLAIGLV-VDDA--IVVVENIHRHIeeGESPLEA 421
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1082601803 299 LIKALAYIMVPVF-----LAAVTTAMGFISFVFGAyltMIKDFGIFTAVGTLIALLLSIFFVPALIS 360
Cdd:NF033617 422 ALKGAREIGFTVIamtltLVAVYLPILFMGGLTGR---LFREFAVTLAGAVIISGIVALTLTPMMCS 485
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
565-724 |
1.15e-06 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 51.14 E-value: 1.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 565 ENIKIELTGMPSVYVKLNNSLIQSQYSSLILAIIMVLLLVGLMLRSIskgVYATIPII-------ATIMILFGFMGITGI 637
Cdd:pfam03176 120 EGLKAYLTGPAATVADLRDAGDRDLGLIEAVTLVVIFIILLIVYRSV---VAALLPLLtvglslgAAQGLVAILAHILGI 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 638 PL-DIATVLVGSIALGIGIDYSIHFITGFNFYLKETGDAEKAIEKTILISGKAIIINVISVAAGFLVLIFSQIVPLQNFG 716
Cdd:pfam03176 197 GLsTFALNLLVVLLIAVGTDYALFLVSRYREELRAGEDREEAVIRAVRGTGKVVTAAGLTVAIAMLALSFARLPVFAQVG 276
|
....*...
gi 1082601803 717 ILVALSMF 724
Cdd:pfam03176 277 PTIAIGVL 284
|
|
| PRK09579 |
PRK09579 |
multidrug efflux RND transporter permease subunit; |
150-360 |
2.98e-06 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 169983 [Multi-domain] Cd Length: 1017 Bit Score: 50.99 E-value: 2.98e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 150 AIVSEDGTASV-VMFTLLPDADKQAVAKEIKSKIKNL--NLPETLYFGglpmMMNDISDLILADIVWLLPIVF---VIIA 223
Cdd:PRK09579 270 SISSFDGIPSVyIGIKATPSANPLDVIKEVRAIMPELesQLPPNLKVS----IAYDATLFIQASIDEVVKTLGeavLIVI 345
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 224 LILLLSFKSFRGVLLPLLTACIAVIWTIGIMVVTGYELTIISNIIPVVLLAVGSAYPIHVLNNINHTL--GKDRKQILIK 301
Cdd:PRK09579 346 VVVFLFLGALRSVLIPVVTIPLSMIGVLFFMQMMGYSINLLTLLAMVLAIGLVVDDAIVVVENIHRHIeeGKSPFDAALE 425
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1082601803 302 ALAYIMVPVF-----LAAVTTAMGFISFVFGAyltMIKDFGIFTAVGTLIALLLSIFFVPALIS 360
Cdd:PRK09579 426 GAREIAMPVVsmtitLAAVYAPIGFLTGLTGA---LFKEFALTLAGAVIISGIVALTLSPMMCA 486
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
536-728 |
4.27e-06 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 50.24 E-value: 4.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 536 IQSRFASVDSKNINEFTSKMNKFIQENNRE--NIKIELTGMPsVYVKLNNSLIQSQySSLI--LAIIMVLLLVGLMLRSI 611
Cdd:COG4258 196 AETRASGFDTDAQQQLVAALRAAFAALNAAfpGAQLLLTGAG-LFAVAAAQQIKHD-ISTIglISLLGILLLLLLVFRSL 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 612 SKGVYATIPI-------IATIMILFGfmGITGIPLDIATVLvgsiaLGIGIDYSIHFITgfNFYLKETGDAEKAIEKTil 684
Cdd:COG4258 274 RPLLLGLLPVavgalagLAAVSLVFG--SVHGITLGFGSSL-----IGVAVDYSLHYLT--HRRAAGEWDPRAALRRI-- 342
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1082601803 685 isGKAIIINVISVAAGFLVLIFSQIVPLQNFGILVALSMFGSGI 728
Cdd:COG4258 343 --WPTLLLGLLTTVLGYLALLFSPFPGLRQLGVFAAAGLLAAAL 384
|
|
| AcrB |
COG0841 |
Multidrug efflux pump subunit AcrB [Defense mechanisms]; |
149-362 |
4.71e-06 |
|
Multidrug efflux pump subunit AcrB [Defense mechanisms];
Pssm-ID: 440603 [Multi-domain] Cd Length: 1015 Bit Score: 50.10 E-value: 4.71e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 149 GAIVSEDGTASV-VMFTLLPDADKQAVAKEIKSKIKNLNLPE--TLYFGGLPMMMNDIsdliLADIVWLLPIVFVIIALI 225
Cdd:COG0841 792 SSINRYNGQRSVtVSANLAPGVSLGEALAAIEELAAELKLPPgvSIEFTGQAEEEQES----FSSLGLAFLLALLLVYLV 867
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 226 LLLSFKSFRGVLLPLLTACIAVIWTIGIMVVTGYELTIISnIIPVVLLaVGsaypIHVLNNI--------NHTLGKDRKQ 297
Cdd:COG0841 868 LAAQFESFIQPLIILLTVPLALIGALLGLLLTGTPLNIYS-QIGLIML-IG----IVVKNAIllvdfanqLREEGMSLRE 941
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1082601803 298 ILIKALAYIMVPVFLAAVTTAMGFISFVF--GAYLTMIKDFGIFTAVGTLIALLLSIFFVPALISAF 362
Cdd:COG0841 942 AILEAARLRLRPILMTSLATILGLLPLALgtGAGAEFRQPLGIAVIGGLLFSTLLTLFVVPVLYVLL 1008
|
|
| 2A0602 |
TIGR00915 |
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins ... |
158-358 |
3.84e-05 |
|
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate]
Pssm-ID: 273335 [Multi-domain] Cd Length: 1044 Bit Score: 47.42 E-value: 3.84e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 158 ASVVMFTLLPDADKQAVAKEIKSKIKNL--NLPETLYFGgLPMMMNDISDLILADIVWLLPIVFVIIALILLLSFKSFRG 235
Cdd:TIGR00915 286 ASGLAIKLATGANALDTAKAVKAELAVLepFFPQGMKYV-YPYDTTPFVEASIEEVVHTLIEAIVLVFLVMYLFLQNFRA 364
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 236 VLLPLLTACIAVIWTIGIMVVTGYE---LTIISNIIPVVLLaVGSAypIHVLNNINHTL---GKDRKQILIKAL-----A 304
Cdd:TIGR00915 365 TLIPTIAVPVVLLGTFAVLAAFGFSintLTMFAMVLAIGLL-VDDA--IVVVENVERVMaeeGLPPKEATRKSMgqiqgA 441
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1082601803 305 YIMVPVFLAAVTTAMGFISFVFGAyltMIKDFGIFTAVGTLIALLLSIFFVPAL 358
Cdd:TIGR00915 442 LVGIAMVLSAVFVPMAFFGGSTGA---IYRQFSITIVSAMALSVLVALILTPAL 492
|
|
| 2A060602 |
TIGR00918 |
The Eukaryotic (Putative) Sterol Transporter (EST) Family; |
207-377 |
5.03e-05 |
|
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
Pssm-ID: 273338 [Multi-domain] Cd Length: 1145 Bit Score: 46.80 E-value: 5.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 207 ILADIVWLLPIVFVIIALILLLSFKSfrGVLLPLLTACIAVIWtiGIMVVTGYELTIISNIIPVVLLAVGSAYPIHVLNN 286
Cdd:TIGR00918 967 LLLSISVVLACTFLVCALLLLNPWTA--GLIVLVLALMTVELF--GMMGLLGIKLSAIPVVILIASVGIGVEFTVHIALG 1042
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 287 INHTLGkDRKQILIKALAYIMVPVFLAAVTTAMGFISFVFGAYLTMIKDFGIFTAVGTLIALLLSIFFVPALISAFSMYG 366
Cdd:TIGR00918 1043 FLTAIG-DRNRRAVLALEHMFAPVLDGALSTLLGVLMLAGSEFDFIVRYFFAVLAVLTCLGVLNGLVLLPVLLSMFGPEP 1121
|
170
....*....|.
gi 1082601803 367 KKVETDQPEKE 377
Cdd:TIGR00918 1122 EVSPAEGRSRL 1132
|
|
| ACR_tran |
pfam00873 |
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ... |
151-358 |
1.07e-04 |
|
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.
Pssm-ID: 395701 [Multi-domain] Cd Length: 1021 Bit Score: 45.75 E-value: 1.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 151 IVSEDGTASVVMFTLLPDADKQAVAKEIKSKI-KNLNLPETLY--FGGlpmmMNDISDLILADIVWLLPIVFVIIALILL 227
Cdd:pfam00873 805 INRYNGFRSIVISGNVAAGDSLGDAMEAMAQIaKQVKLPPGYGytWTG----QFEQEQLAGNSLPILIALALLVVFLVLA 880
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 228 LSFKSFRGVLLPLLTACIAVIWTIGIMVVTGYELTIISNIIPVVLLAVGSAYPIHVLNNINHTL---GKDRKQILIKALA 304
Cdd:pfam00873 881 ALYESWSDPLSIMLTVPLALVGALLALWLRGLPNSVYAQVGLILLIGLAVKNAILMVEFANELReqeGKSLEEAILEACR 960
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1082601803 305 YIMVPVFLAAVTTAMGFISFVF--GAYLTMIKDFGIFTAVGTLIALLLSIFFVPAL 358
Cdd:pfam00873 961 LRLRPILMTALAAILGVLPLALstGAGSELQQPLGIVVFGGLVTSTVLTLLVVPVF 1016
|
|
| PRK09577 |
PRK09577 |
multidrug efflux RND transporter permease subunit; |
220-376 |
2.54e-04 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 169981 [Multi-domain] Cd Length: 1032 Bit Score: 44.46 E-value: 2.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 220 VIIALILLLSFKSFRGVLLPLLTACIAVIWTIGIMVVTGYELTIISNIIPVVLLAVGSAYPIHVLNNINHTLGKDR---K 296
Cdd:PRK09577 348 VLVFLVMFLFMQNFRATLIPTLVVPVALLGTFGVMLAAGFSINVLTMFGMVLAIGILVDDAIVVVENVERLMVEEGlspY 427
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 297 QILIKAL-----AYIMVPVFLAAVTTAMGFISfvfGAYLTMIKDFGIFTAVGTLIALLLSIFFVPALISAFSmygKKVET 371
Cdd:PRK09577 428 DATVKAMkqisgAIVGITVVLTSVFVPMAFFG---GAVGNIYRQFALSLAVSIGFSAFLALSLTPALCATLL---KPVDG 501
|
....*
gi 1082601803 372 DQPEK 376
Cdd:PRK09577 502 DHHEK 506
|
|
| 2A0601 |
TIGR00914 |
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation ... |
144-417 |
6.68e-04 |
|
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation antiporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 129992 [Multi-domain] Cd Length: 1051 Bit Score: 43.21 E-value: 6.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 144 KEMYKGAiVSEDGTASVV-MFTLLPDADKQAVAKEIKSKIKNLN--LPEtlyfGGLPMMMNDISDLILADIVWL---LPI 217
Cdd:TIGR00914 275 KELRTGA-ATENGKEVVLgTVFMLIGENSRTVAQAVGDKLETINktLPE----GVEIVTTYDRSQLVDAAIATVkknLLE 349
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 218 VFVIIALILLLSFKSFRGVLLPLLTACIAVIWTIGIMVvtgyELTIISNIIPVVLLAVG---SAYPIHVLNNI------N 288
Cdd:TIGR00914 350 GALLVIVILFLFLGNIRAALIAATVIPLSLLITFIGMV----FQGISANLMSLGALDFGlivDGAVVIVENAHrrlaeaQ 425
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 289 HTLG-----KDRKQILIKALAYIMVPVFLAAVTTAMGFI-SFVF-GAYLTMIKDFGIFTAVGTLIALLLSIFFVPALISA 361
Cdd:TIGR00914 426 HHHGrqltlKERLHEVFAASREVRRPLIFGQLIITLVFLpIFTLtGVEGKMFHPMAFTVVLALAGAMILSLTFVPAAVAL 505
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 1082601803 362 FsmYGKKVetdqPEKENILTH---KILQPIVTLLFKHPKYSLTAWGILLLLSIGGMFFL 417
Cdd:TIGR00914 506 F--IRGKV----AEKENRLMRvlkRRYEPLLERVLAWPAVVLGAAAVSIVLVVWIASRV 558
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
621-724 |
1.11e-03 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 42.29 E-value: 1.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 621 IIATIMILFGFMGITgipLDIATVLVG-----SIA-----LGIGIDYSIHFITGFNFYLKETGDAEKAIEKTILISGKAI 690
Cdd:TIGR03480 296 VFAVLVTLIVGLILT---AAFATLAVGhlnliSVAfavlfIGLGVDFAIQFSLRYREERFRGGNHREALSVAARRMGAAL 372
|
90 100 110
....*....|....*....|....*....|....
gi 1082601803 691 IINVISVAAGFLVLIFSQIVPLQNFGILVALSMF 724
Cdd:TIGR03480 373 LLAALATAAGFFAFLPTDYKGVSELGIIAGTGMF 406
|
|
| Patched |
pfam02460 |
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ... |
200-363 |
1.22e-03 |
|
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Pssm-ID: 308203 [Multi-domain] Cd Length: 793 Bit Score: 42.34 E-value: 1.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 200 MNDISDLILADIVWLLpIVFVIIALILLLSFKSFRGVLLPLLTACIAVIwtiGIMVVTGYELTIISNIipVVLLAVGSA- 278
Cdd:pfam02460 634 YLTILPSTIQNIVITL-ICMFIVCFLFIPNPPCVFVITLAIASIDIGVF---GFLSLWGVDLDPISMI--TIIMSIGFSv 707
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 279 -YPIHVLNNINHTLGKDRKQILIKALAYIMVPVFLAAVTTAMGFISFVF-GAYltMIKDFG--IFTAVGtlIALLLSIFF 354
Cdd:pfam02460 708 dFSAHIAYHFVRSRGDTPAERVVDALEALGWPVFQGGLSTILGVLVLLFvPSY--MVVVFFktVFLVVA--IGLLHGLFI 783
|
....*....
gi 1082601803 355 VPALISAFS 363
Cdd:pfam02460 784 LPIILSLFV 792
|
|
| PRK09579 |
PRK09579 |
multidrug efflux RND transporter permease subunit; |
221-371 |
4.70e-03 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 169983 [Multi-domain] Cd Length: 1017 Bit Score: 40.59 E-value: 4.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 221 IIALILLLSFKSFRGVLLPLLTACIAVIWTIGIMVVTGYELTIISNIIPVVLLAVGSAYPIHVL---NNINHTLGKDRKQ 297
Cdd:PRK09579 856 IIFLVLAAQFESFRDPLVILVTVPLSICGALIPLFLGVSSMNIYTQVGLVTLIGLISKHGILIVefaNQLRHEQGLSRRE 935
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1082601803 298 ILIKALAYIMVPVFLAAVTTAMGFISFVF--GAYLTMIKDFGIFTAVGTLIALLLSIFFVPALISAFSMYGKKVET 371
Cdd:PRK09579 936 AIEEAAAIRLRPVLMTTAAMVFGMVPLILatGAGAVSRFDIGLVIATGMSIGTLFTLFVLPCIYTLLAKPDAAPGV 1011
|
|
| 2A060601 |
TIGR00917 |
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ... |
204-359 |
4.95e-03 |
|
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]
Pssm-ID: 273337 [Multi-domain] Cd Length: 1205 Bit Score: 40.28 E-value: 4.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 204 SDLILADIVWLLPIVFVIIALILLLSFKSF----------RGVLLPLLTACIAViwtiGIMVVTGYELT-IISNIIPVVL 272
Cdd:TIGR00917 572 ADVITIAISYLVMFAYISLTLGDSPRLKSLyvtskvllglSGILIVMLSVLGSV----GVFSAVGLKSTlIIMEVIPFLV 647
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 273 LAVGSA----------------YPIHVLNNINHTLgkdrKQILIKALAYIMVPVFLAAVTTAmgfISFVFGAYLTM--IK 334
Cdd:TIGR00917 648 LAVGVDnifilvffyfyleyfyRQVGVDNEQELTL----ERRLSRALMEVGPSITLASLSEI---LAFALGALIKMpaVR 720
|
170 180
....*....|....*....|....*
gi 1082601803 335 DFGIFTAVGTLIALLLSIFFVPALI 359
Cdd:TIGR00917 721 VFSMFAVLAVFLDFLLQITAFVALL 745
|
|
| CusA |
COG3696 |
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism]; |
213-375 |
5.26e-03 |
|
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
Pssm-ID: 442911 [Multi-domain] Cd Length: 1031 Bit Score: 40.40 E-value: 5.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 213 WLLPIVFVIIALILLLSFKSFRGVLLPLLTACIAVIWTIGIMVVTGYELTIISniipvvllAVG--SAYPIHVLN----- 285
Cdd:COG3696 868 IVVPLALLLIFLLLYLAFGSVRDALLILLNVPFALIGGVLALWLRGMPLSVSA--------GVGfiALFGVAVLNgvvlv 939
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082601803 286 -NINHTL--GKDRKQILIKALAYIMVPVFLAAVTTAMGFISFVFGAyltmikdfGI-------FTAV---GTLIALLLSI 352
Cdd:COG3696 940 sYINQLRaeGLDLREAIIEGALERLRPVLMTALVAALGLLPMALST--------GPgsevqrpLATVvigGLITSTLLTL 1011
|
170 180
....*....|....*....|...
gi 1082601803 353 FFVPALisaFSMYGKKVETDQPE 375
Cdd:COG3696 1012 LVLPAL---YLLFGRRRLRRAAA 1031
|
|
| |
