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Conserved domains on  [gi|1082783986|gb|OGB00968|]
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TetR family transcriptional regulator [Burkholderiales bacterium RIFCSPHIGHO2_12_63_9]

Protein Classification

TetR/AcrR family transcriptional regulator( domain architecture ID 11442015)

TetR/AcrR family transcriptional regulator may control genes involved in one of a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

CATH:  1.10.10.60|1.10.357.10
Gene Ontology:  GO:0003700|GO:0003677|GO:0006355
PubMed:  23602932
SCOP:  4000333

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
14-176 7.86e-22

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


:

Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 87.26  E-value: 7.86e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082783986  14 ADGPATRERVLLEAARLFRHHGYAATTLREVADAAGVKAGSIYYHFESKEQILGEVLDKgitiVADAVRTRVAALPESAP 93
Cdd:COG1309     2 RRREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLER----LLEELLAALEEALAAED 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082783986  94 WRDRIAAGIEGHLWGMLHYGDFTSANIRIYGQIPisaknRHRIVRRAYADYWDRLFESALASGELRQDTSTAMIRLFVIG 173
Cdd:COG1309    78 PRERLRALLRAYLEFLAENPALARLLLAEAAELP-----ELRAALRALLRRLRALLAELLRAGGLLADVDPDALARALLA 152


                  ...
gi 1082783986 174 ALN 176
Cdd:COG1309   153 LLD 155
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
14-176 7.86e-22

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 87.26  E-value: 7.86e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082783986  14 ADGPATRERVLLEAARLFRHHGYAATTLREVADAAGVKAGSIYYHFESKEQILGEVLDKgitiVADAVRTRVAALPESAP 93
Cdd:COG1309     2 RRREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLER----LLEELLAALEEALAAED 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082783986  94 WRDRIAAGIEGHLWGMLHYGDFTSANIRIYGQIPisaknRHRIVRRAYADYWDRLFESALASGELRQDTSTAMIRLFVIG 173
Cdd:COG1309    78 PRERLRALLRAYLEFLAENPALARLLLAEAAELP-----ELRAALRALLRRLRALLAELLRAGGLLADVDPDALARALLA 152


                  ...
gi 1082783986 174 ALN 176
Cdd:COG1309   153 LLD 155
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
24-69 5.35e-14

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 63.58  E-value: 5.35e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1082783986  24 LLEAA-RLFRHHGYAATTLREVADAAGVKAGSIYYHFESKEQILGEV 69
Cdd:pfam00440   1 ILDAArELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
19-174 8.32e-13

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 64.15  E-value: 8.32e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082783986  19 TRERVLLEAARLFRHHGYAATTLREVADAAGVKAGSIYYHFESKEQILGEVLDKgitivadAVRTRVAALPesaPWRDRI 98
Cdd:NF041196    7 TRRAILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEALARAVLEE-------QVARLREAVE---PQRAGG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082783986  99 AAGIE-----GHLWG-MLHYGDFTSANIRiygqIPISAKNRHRIVRRAYADYWD---RLFESALASGELRQDTSTAMIRL 169
Cdd:NF041196   77 GSKLQelvdlTHVLArRLRTDPVVRAGVR----LSIEQAAIGAGLPTPYREWIDlvaELLAEARAAGELLPGVDPEEAAR 152


                  ....*
gi 1082783986 170 FVIGA 174
Cdd:NF041196  153 LLVGA 157
PRK09975 PRK09975
DNA-binding transcriptional regulator EnvR; Provisional
 11-96 1.51e-11

DNA-binding transcriptional regulator EnvR; Provisional


Pssm-ID: 182177 [Multi-domain]  Cd Length: 213  Bit Score: 61.29  E-value: 1.51e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082783986  11 KDNADGPATRERVLLEAARLFRHHGYAATTLREVADAAGVKAGSIYYHFESKEQILGEVLDKGITiVADAVRTRVAALPE 90
Cdd:PRK09975    4 KTKAEALKTRQELIETAIAQFALRGVSNTTLNDIADAANVTRGAIYWHFENKTQLFNEMWLQQPP-LRELIQEHLTAGLE 82


                  ....*.
gi 1082783986  91 SAPWRD 96
Cdd:PRK09975   83 HDPLQQ 88
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
14-176 7.86e-22

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 87.26  E-value: 7.86e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082783986  14 ADGPATRERVLLEAARLFRHHGYAATTLREVADAAGVKAGSIYYHFESKEQILGEVLDKgitiVADAVRTRVAALPESAP 93
Cdd:COG1309     2 RRREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLER----LLEELLAALEEALAAED 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082783986  94 WRDRIAAGIEGHLWGMLHYGDFTSANIRIYGQIPisaknRHRIVRRAYADYWDRLFESALASGELRQDTSTAMIRLFVIG 173
Cdd:COG1309    78 PRERLRALLRAYLEFLAENPALARLLLAEAAELP-----ELRAALRALLRRLRALLAELLRAGGLLADVDPDALARALLA 152


                  ...
gi 1082783986 174 ALN 176
Cdd:COG1309   153 LLD 155
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
24-69 5.35e-14

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 63.58  E-value: 5.35e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1082783986  24 LLEAA-RLFRHHGYAATTLREVADAAGVKAGSIYYHFESKEQILGEV 69
Cdd:pfam00440   1 ILDAArELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
19-174 8.32e-13

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 64.15  E-value: 8.32e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082783986  19 TRERVLLEAARLFRHHGYAATTLREVADAAGVKAGSIYYHFESKEQILGEVLDKgitivadAVRTRVAALPesaPWRDRI 98
Cdd:NF041196    7 TRRAILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEALARAVLEE-------QVARLREAVE---PQRAGG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082783986  99 AAGIE-----GHLWG-MLHYGDFTSANIRiygqIPISAKNRHRIVRRAYADYWD---RLFESALASGELRQDTSTAMIRL 169
Cdd:NF041196   77 GSKLQelvdlTHVLArRLRTDPVVRAGVR----LSIEQAAIGAGLPTPYREWIDlvaELLAEARAAGELLPGVDPEEAAR 152


                  ....*
gi 1082783986 170 FVIGA 174
Cdd:NF041196  153 LLVGA 157
YbjK COG3226
DNA-binding transcriptional regulator YbjK [Transcription];
14-106 1.53e-12

DNA-binding transcriptional regulator YbjK [Transcription];


Pssm-ID: 442459 [Multi-domain]  Cd Length: 191  Bit Score: 63.42  E-value: 1.53e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082783986  14 ADGPATRERVLLEAARLFRHHGYAATTLREVADAAGVKAGSIYYHFESKEQILGEVLDKGITIVADAVRTRVAALPESAP 93
Cdd:COG3226     4 RRGEERRERILEAALRVIARDGVRGVTHRAVAAEAGVPLGSTTYYFRTRDELLAAAFERLAEREAARLRALLAAADDLED 83

                          90
                  ....*....|...
gi 1082783986  94 WRDRIAAGIEGHL 106
Cdd:COG3226    84 AAEALADLLAELL 96
TetR_C_24 pfam17932
Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the ...
 91-204 5.86e-12

Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in family members such as HTH-type transcriptional repressor KstR2 as well as fatty acid metabolism regulator proteins. In Mycobacterium smegmatis, KstR2 is involved in involved in cholesterol catabolism, while YsiA in Bacillus subtilis is involved in fatty acid degradation.


Pssm-ID: 465574  Cd Length: 114  Bit Score: 59.88  E-value: 5.86e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082783986  91 SAPWRDRIAAGIEGHLwgMLHYGDFTSANIRIYGQIPISAKNRHRIV--RRAYADYWDRLFESALASGELRqDTSTAMIR 168
Cdd:pfam17932   1 GGSPVERLRALVRAHV--RVHAERRDEAAVFLRELRSLSPEHRAEIRalRREYERLLRDLIEEGVAAGEFR-DLDPKLAA 77

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1082783986 169 LFVIGALNWTVEWYNPQ-RGSFQDFSRQITAIVFDGI 204
Cdd:pfam17932  78 LAILGMLNWVYRWYRPDgPLSPEEIADQYADLLLRGL 114
PRK09975 PRK09975
DNA-binding transcriptional regulator EnvR; Provisional
 11-96 1.51e-11

DNA-binding transcriptional regulator EnvR; Provisional


Pssm-ID: 182177 [Multi-domain]  Cd Length: 213  Bit Score: 61.29  E-value: 1.51e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082783986  11 KDNADGPATRERVLLEAARLFRHHGYAATTLREVADAAGVKAGSIYYHFESKEQILGEVLDKGITiVADAVRTRVAALPE 90
Cdd:PRK09975    4 KTKAEALKTRQELIETAIAQFALRGVSNTTLNDIADAANVTRGAIYWHFENKTQLFNEMWLQQPP-LRELIQEHLTAGLE 82


                  ....*.
gi 1082783986  91 SAPWRD 96
Cdd:PRK09975   83 HDPLQQ 88
PRK10668 PRK10668
DNA-binding transcriptional repressor AcrR; Provisional
 19-69 4.99e-10

DNA-binding transcriptional repressor AcrR; Provisional


Pssm-ID: 182632 [Multi-domain]  Cd Length: 215  Bit Score: 56.94  E-value: 4.99e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1082783986  19 TRERVLLEAARLFRHHGYAATTLREVADAAGVKAGSIYYHFESKEQILGEV 69
Cdd:PRK10668   12 TRQHILDAALRLFSQQGVSATSLADIAKAAGVTRGAIYWHFKNKSDLFSEI 62
PRK14996 PRK14996
TetR family transcriptional regulator; Provisional
 20-173 1.82e-06

TetR family transcriptional regulator; Provisional


Pssm-ID: 184958 [Multi-domain]  Cd Length: 192  Bit Score: 46.62  E-value: 1.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082783986  20 RERVLLEAARLFRHHGYAATTLREVADAAGVKAGSIYYHFESKEQILGEVLDKGITIVADAvrtrvAALPESAPWRDRia 99
Cdd:PRK14996   10 REVILQAAMRVALAEGFAAMTVRRIASEAQVAAGQVHHHFSSAGELKALAFIHLIRQLLDA-----EQVPQTASWRER-- 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082783986 100 agieghLWGMLHYGD-FTSANIRIYGQIPISAKNRHRIvRRAYA---DYWDR----LFESALASGELRQDTSTAMI--RL 169
Cdd:PRK14996   83 ------LHAMLGSEDgRFEPYIRLWREAQILADRDPEI-KDAYLltmQMWHQetvaIIEQGKAAGEFRSTSNATDIawRL 155


                  ....*.
gi 1082783986 170 --FVIG 173
Cdd:PRK14996  156 iaLVCG 161
PRK15008 PRK15008
HTH-type transcriptional regulator RutR; Provisional
 1-76 2.04e-03

HTH-type transcriptional regulator RutR; Provisional


Pssm-ID: 184970 [Multi-domain]  Cd Length: 212  Bit Score: 37.99  E-value: 2.04e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1082783986   1 MKPSTEAKLSKDNADGPATRERVLLEAARLFRHHGYAATTLREVADAAGVKAGSIYYHFESKEQILGEVLDKGITI 76
Cdd:PRK15008    1 MTQGAVKTTGKRSRAVSAKKKAILSAALDTFSQFGFHGTRLEQIAELAGVSKTNLLYYFPSKEALYIAVLRQILDI 76
PRK00767 PRK00767
transcriptional regulator BetI; Validated
 20-104 6.93e-03

transcriptional regulator BetI; Validated


Pssm-ID: 179115 [Multi-domain]  Cd Length: 197  Bit Score: 35.97  E-value: 6.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082783986  20 RERVLLEAA-RLFRHHGYAATTLREVADAAGVKAGSIYYHFESKEQILGEVLDKGITIVADAVRTRVAAlPESAPwRDRI 98
Cdd:PRK00767   10 RRQQLIDATlRAIGEVGLLDATIAQIARRAGVSTGIISHYFGGKDGLLEATMRHLLRQLGDAVLARLAA-AADTP-RARL 87


                  ....*.
gi 1082783986  99 AAGIEG 104
Cdd:PRK00767   88 RAIVEA 93
PRK11202 PRK11202
HTH-type transcriptional repressor FabR;
19-59 9.54e-03

HTH-type transcriptional repressor FabR;


Pssm-ID: 236881 [Multi-domain]  Cd Length: 203  Bit Score: 35.75  E-value: 9.54e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1082783986  19 TReRVLLEAA--RLFRHHGYAATTLREVADAAGVKAGSIYYHF 59
Cdd:PRK11202   12 TR-RALIDAAfsQLSAERSFSSLSLREVAREAGIAPTSFYRHF 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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