|
Name |
Accession |
Description |
Interval |
E-value |
| DinP |
COG0389 |
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ... |
12-326 |
8.56e-88 |
|
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];
Pssm-ID: 440158 [Multi-domain] Cd Length: 336 Bit Score: 266.62 E-value: 8.56e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 12 ILHIDLNSCFATVEQQARPLLRGRPLAV---TNRltvnACVIAASYEAKAHGVNVGMRLSEAKELISDLITVETDPPKYH 88
Cdd:COG0389 3 ILHVDMDAFYASVEQRDRPELRGKPVAVggdNNR----GVVAAASYEARAFGVRSGMPLFQARRLCPDLVVLPPDFELYR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 89 YVYQQLARIMKSYSPAVTMKSIDEGIIDFHGTRQAInkRPLTAIGYEIKQRLRDGVGcwMKCNIGIAPNRFLAKTAASLH 168
Cdd:COG0389 79 DVSRRVMAILERYTPLVEPLSIDEAFLDVTGSARLF--GSAEAIARRIRRRIRRETG--LTVSVGIAPNKFLAKIASDLA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 169 KPDGLDVITHANLRQVLADLQLTDLTGIAERNQARLNACGIYTPLQFLDASAKVLKnQVFkSIIGEDWHQRLRGW---EV 245
Cdd:COG0389 155 KPDGLTVIPPGEVAAFLAPLPVEKLWGVGPKTAEKLARLGIRTIGDLAALPRAELR-RRF-GKVGERLYRLARGIdprPV 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 246 DNHSwGTKSIGRQFVMDDYHASEETVRSRLALLCESTGLKMRHKGLCARGISIHLRYKNGDHWQARKAFRSTFFSNGEIY 325
Cdd:COG0389 233 EPRR-PRKSIGVERTFGEDLTDLEELEAALRRLAERLAERLRRQGLGARTVTVKLRTSDFRTTTRSRTLPEPTDDTAELL 311
|
.
gi 1084127881 326 R 326
Cdd:COG0389 312 R 312
|
|
| PolY |
cd00424 |
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases ... |
13-322 |
5.24e-59 |
|
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Most TLS polymerases are members of the Y-family, including Pol eta, Pol kappa/IV, Pol iota, Rev1, and Pol V, which is found exclusively in bacteria. In eukaryotes, the B-family polymerase Pol zeta also functions as a TLS polymerase. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176453 [Multi-domain] Cd Length: 343 Bit Score: 192.96 E-value: 5.24e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 13 LHIDLNSCFATVEQQARPLLRGRPLAVTNRLTVNACVIAASYEAKAHGVNVGMRLSEAKELISDLITVETDPPKYHYVYQ 92
Cdd:cd00424 1 LHIDFDNFFASVEQLARPELKGRPVVVVPFNSDSTCVIACSYEARKYGVKRGMPVREARKMCPNLILVPARLDLYRRLSE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 93 QLARIMKSYSPAVTMKSIDEGIIDFHGTrqAINKRPLTAIGYEIKQRLRDGVGcWMKCNIGIAPNRFLAKTAASLHKPDG 172
Cdd:cd00424 81 RLLSELEEVAPLVEVASIDELFLDLTGS--ARLLGLGSEVALRIKRHIAEQLG-GITASIGIASNKLLAKLAAKYAKPDG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 173 LDVITHANLRQVLADLQLTDLTGIAERNQARLNACGIYTPLQFLDASAKVLKNQVFkSIIGEDWHQRLRGweVDNH---- 248
Cdd:cd00424 158 LTILDPEDLPGFLSKLPLTDLPGIGAVTAKRLEAVGINPIGDLLAASPDALLALWG-GVSGERLWYALRG--IDDEplsp 234
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1084127881 249 SWGTKSIGRQFVMDDYHASEETVRSRLALLCESTGLKMRHKGLCARGISIHLRYKNGdhwqaRKAFRSTFFSNG 322
Cdd:cd00424 235 PRPRKSFSHERVLPRDSRNAEDARPLLRLLLEKLARRLRRDGRGATRLRLWLRTVDG-----RWSGHADIPSRS 303
|
|
| PRK01810 |
PRK01810 |
DNA polymerase IV; Validated |
12-304 |
1.77e-46 |
|
DNA polymerase IV; Validated
Pssm-ID: 179337 [Multi-domain] Cd Length: 407 Bit Score: 162.12 E-value: 1.77e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 12 ILHIDLNSCFATVEQQARPLLRGRPLAVT-NRLTVNACVIAASYEAKAHGVNVGMRLSEAKELISDLITVETDPPKYHYV 90
Cdd:PRK01810 7 IFHVDMNSFFASVEIAYDPSLQGKPLAVAgNEKERKGIIVTCSYEARAYGIRTTMPLWEAKRLCPQLIVRRPNFDRYREA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 91 YQQLARIMKSYSPAVTMKSIDEGIIDFHGTRQAInkRPLtAIGYEIKQRLRDGVGcwMKCNIGIAPNRFLAKTAASLHKP 170
Cdd:PRK01810 87 SRQMFQILSEFTPLVQPVSIDEGYLDITDCYALG--SPL-EIAKMIQQRLLTELQ--LPCSIGIAPNKFLAKMASDMKKP 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 171 DGLDVITHANLRQVLADLQLTDLTGIAERNQARLNACGIYTPLQFLDASAKVLKNQVfkSIIGEDWHQRLRGW---EVDN 247
Cdd:PRK01810 162 LGITVLRKRDVPEMLWPLPVGEMHGIGEKTAEKLKDIGIQTIGDLAKADEHILRAKL--GINGVRLQRRANGIddrPVDP 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1084127881 248 HSWG-TKSIGRQFVMDDYHASEETVRSRLALLCESTGLKMRHKGLCARGISIHLRYKN 304
Cdd:PRK01810 240 EAIYqFKSVGNSTTLSHDMDEEKELLDVLRRLSKSVSKRLQKKTVVSYNVQIMIRYHD 297
|
|
| IMS |
pfam00817 |
impB/mucB/samB family; These proteins are involved in UV protection (Swiss). |
15-165 |
1.23e-35 |
|
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
Pssm-ID: 425885 [Multi-domain] Cd Length: 148 Bit Score: 126.15 E-value: 1.23e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 15 IDLNSCFATVEQQARPLLRGRPLAVTNRlTVNACVIAASYEAKAHGVNVGMRLSEAKELISDLITVETDPPKYHYVYQQL 94
Cdd:pfam00817 1 IDMDAFFASVELLRDPELKGKPVAVGGG-NGRGIVAAASYEARKYGVRSGMPVFEAKKLCPNLIVVPPDLELYRRASRKI 79
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1084127881 95 ARIMKSYSPAVTMK-SIDEGIIDFHGTRQaiNKRPLTAIGYEIKQRLRDGVGCwmKCNIGIAPNRFLAKTAA 165
Cdd:pfam00817 80 FEILRRFSTPKVEQaSIDEAFLDLTGLEK--LFGAEEALAKRLRREIAEETGL--TCSIGIAPNKLLAKLAS 147
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| DinP |
COG0389 |
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ... |
12-326 |
8.56e-88 |
|
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];
Pssm-ID: 440158 [Multi-domain] Cd Length: 336 Bit Score: 266.62 E-value: 8.56e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 12 ILHIDLNSCFATVEQQARPLLRGRPLAV---TNRltvnACVIAASYEAKAHGVNVGMRLSEAKELISDLITVETDPPKYH 88
Cdd:COG0389 3 ILHVDMDAFYASVEQRDRPELRGKPVAVggdNNR----GVVAAASYEARAFGVRSGMPLFQARRLCPDLVVLPPDFELYR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 89 YVYQQLARIMKSYSPAVTMKSIDEGIIDFHGTRQAInkRPLTAIGYEIKQRLRDGVGcwMKCNIGIAPNRFLAKTAASLH 168
Cdd:COG0389 79 DVSRRVMAILERYTPLVEPLSIDEAFLDVTGSARLF--GSAEAIARRIRRRIRRETG--LTVSVGIAPNKFLAKIASDLA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 169 KPDGLDVITHANLRQVLADLQLTDLTGIAERNQARLNACGIYTPLQFLDASAKVLKnQVFkSIIGEDWHQRLRGW---EV 245
Cdd:COG0389 155 KPDGLTVIPPGEVAAFLAPLPVEKLWGVGPKTAEKLARLGIRTIGDLAALPRAELR-RRF-GKVGERLYRLARGIdprPV 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 246 DNHSwGTKSIGRQFVMDDYHASEETVRSRLALLCESTGLKMRHKGLCARGISIHLRYKNGDHWQARKAFRSTFFSNGEIY 325
Cdd:COG0389 233 EPRR-PRKSIGVERTFGEDLTDLEELEAALRRLAERLAERLRRQGLGARTVTVKLRTSDFRTTTRSRTLPEPTDDTAELL 311
|
.
gi 1084127881 326 R 326
Cdd:COG0389 312 R 312
|
|
| PolY |
cd00424 |
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases ... |
13-322 |
5.24e-59 |
|
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Most TLS polymerases are members of the Y-family, including Pol eta, Pol kappa/IV, Pol iota, Rev1, and Pol V, which is found exclusively in bacteria. In eukaryotes, the B-family polymerase Pol zeta also functions as a TLS polymerase. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176453 [Multi-domain] Cd Length: 343 Bit Score: 192.96 E-value: 5.24e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 13 LHIDLNSCFATVEQQARPLLRGRPLAVTNRLTVNACVIAASYEAKAHGVNVGMRLSEAKELISDLITVETDPPKYHYVYQ 92
Cdd:cd00424 1 LHIDFDNFFASVEQLARPELKGRPVVVVPFNSDSTCVIACSYEARKYGVKRGMPVREARKMCPNLILVPARLDLYRRLSE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 93 QLARIMKSYSPAVTMKSIDEGIIDFHGTrqAINKRPLTAIGYEIKQRLRDGVGcWMKCNIGIAPNRFLAKTAASLHKPDG 172
Cdd:cd00424 81 RLLSELEEVAPLVEVASIDELFLDLTGS--ARLLGLGSEVALRIKRHIAEQLG-GITASIGIASNKLLAKLAAKYAKPDG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 173 LDVITHANLRQVLADLQLTDLTGIAERNQARLNACGIYTPLQFLDASAKVLKNQVFkSIIGEDWHQRLRGweVDNH---- 248
Cdd:cd00424 158 LTILDPEDLPGFLSKLPLTDLPGIGAVTAKRLEAVGINPIGDLLAASPDALLALWG-GVSGERLWYALRG--IDDEplsp 234
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1084127881 249 SWGTKSIGRQFVMDDYHASEETVRSRLALLCESTGLKMRHKGLCARGISIHLRYKNGdhwqaRKAFRSTFFSNG 322
Cdd:cd00424 235 PRPRKSFSHERVLPRDSRNAEDARPLLRLLLEKLARRLRRDGRGATRLRLWLRTVDG-----RWSGHADIPSRS 303
|
|
| PolY_Pol_IV_kappa |
cd03586 |
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ... |
13-304 |
2.70e-56 |
|
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.
Pssm-ID: 176459 [Multi-domain] Cd Length: 334 Bit Score: 185.42 E-value: 2.70e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 13 LHIDLNSCFATVEQQARPLLRGRPLAV--TNRLTVnacVIAASYEAKAHGVNVGMRLSEAKELISDLITVETDPPKYHYV 90
Cdd:cd03586 1 IHIDMDAFYASVEQRDNPELKGKPVAVggSSDRGV---VSTASYEARKFGVRSAMPIFQAKKLCPNLIFVPPRFDKYREV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 91 YQQLARIMKSYSPAVTMKSIDEGIIDFHGTRQaiNKRPLTAIGYEIKQRLRDGVGcwMKCNIGIAPNRFLAKTAASLHKP 170
Cdd:cd03586 78 SRQIMEILREYTPLVEPLSIDEAYLDVTDYVR--LFGSATEIAKEIRARIREETG--LTASAGIAPNKFLAKIASDLNKP 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 171 DGLDVITHANLRQVLADLQLTDLTGIAERNQARLNACGIYTPLQFLDASAKVLKnQVFKSiIGEDWHQRLRG---WEVDN 247
Cdd:cd03586 154 NGLTVIPPEDVEEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLK-KLFGK-SGRRLYELARGidnRPVEP 231
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 1084127881 248 HsWGTKSIGRQFVMDDYHASEETVRSRLALLCESTGLKMRHKGLCARGISIHLRYKN 304
Cdd:cd03586 232 D-RERKSIGVERTFSEDLTDPEELLEELLELAEELAERLRKRGLKGRTVTVKLKYAD 287
|
|
| PRK01810 |
PRK01810 |
DNA polymerase IV; Validated |
12-304 |
1.77e-46 |
|
DNA polymerase IV; Validated
Pssm-ID: 179337 [Multi-domain] Cd Length: 407 Bit Score: 162.12 E-value: 1.77e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 12 ILHIDLNSCFATVEQQARPLLRGRPLAVT-NRLTVNACVIAASYEAKAHGVNVGMRLSEAKELISDLITVETDPPKYHYV 90
Cdd:PRK01810 7 IFHVDMNSFFASVEIAYDPSLQGKPLAVAgNEKERKGIIVTCSYEARAYGIRTTMPLWEAKRLCPQLIVRRPNFDRYREA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 91 YQQLARIMKSYSPAVTMKSIDEGIIDFHGTRQAInkRPLtAIGYEIKQRLRDGVGcwMKCNIGIAPNRFLAKTAASLHKP 170
Cdd:PRK01810 87 SRQMFQILSEFTPLVQPVSIDEGYLDITDCYALG--SPL-EIAKMIQQRLLTELQ--LPCSIGIAPNKFLAKMASDMKKP 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 171 DGLDVITHANLRQVLADLQLTDLTGIAERNQARLNACGIYTPLQFLDASAKVLKNQVfkSIIGEDWHQRLRGW---EVDN 247
Cdd:PRK01810 162 LGITVLRKRDVPEMLWPLPVGEMHGIGEKTAEKLKDIGIQTIGDLAKADEHILRAKL--GINGVRLQRRANGIddrPVDP 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1084127881 248 HSWG-TKSIGRQFVMDDYHASEETVRSRLALLCESTGLKMRHKGLCARGISIHLRYKN 304
Cdd:PRK01810 240 EAIYqFKSVGNSTTLSHDMDEEKELLDVLRRLSKSVSKRLQKKTVVSYNVQIMIRYHD 297
|
|
| PRK03103 |
PRK03103 |
DNA polymerase IV; Reviewed |
12-301 |
2.10e-45 |
|
DNA polymerase IV; Reviewed
Pssm-ID: 235104 [Multi-domain] Cd Length: 409 Bit Score: 159.01 E-value: 2.10e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 12 ILHIDLNSCFATVEQQARPLLRGRPLAVTNRLTVNACVI-AASYEAKAHGVNVGMRLSEAKELISDLITVETDPPKYHYV 90
Cdd:PRK03103 5 ILLVDMQSFYASVEKAANPELKGRPVIVSGDPERRSGVVlAACPLAKAYGVKTAERLWEAQQKCPDLVVVKPRMQRYIDV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 91 YQQLARIMKSYSPAVTMKSIDEGIIDFHGTRQAINkrPLTAIGYEIKQRLRDGVGCWmkCNIGIAPNRFLAKTAASLH-- 168
Cdd:PRK03103 85 SLQITRILEDFTDLVEPFSIDEQFLDVTGSQKLFG--SPLEIAQKIQQRIMRETGVY--ARVGIGPNKLLAKMACDNFak 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 169 -KPDGLDVITHANLRQVLADLQLTDLTGIAERNQARLNACGIYTPLQFLDASAKVLKNQVfkSIIGEDWHQRLRGWE--- 244
Cdd:PRK03103 161 kNPDGLFTLDKEDVPADLWPLPVRKLFGVGSRMEKHLRRMGIRTIGQLANTPLERLKKRW--GINGEVLWRTANGIDysp 238
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 1084127881 245 VDNHSW-GTKSIGRQFVMD-DYHASEEtVRSRLALLCESTGLKMRHKGLCARGISIHLR 301
Cdd:PRK03103 239 VTPHSLdRQKAIGHQMTLPrDYRGFEE-IKVVLLELCEEVCRRARAKGYMGRTVSVSLR 296
|
|
| PolY_Pol_V_umuC |
cd01700 |
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion ... |
13-302 |
2.52e-44 |
|
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion synthesis (TLS) polymerase that consists of the heterotrimer of one umuC and two umuD subunits. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol V, RecA, single stranded DNA-binding protein, beta sliding clamp, and gamma clamp loading complex are responsible for inducing the SOS response in bacteria to repair UV-induced DNA damage.
Pssm-ID: 176454 [Multi-domain] Cd Length: 344 Bit Score: 154.63 E-value: 2.52e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 13 LHIDLNSCFATVEQQARPLLRGRPLAVtnrLTVN-ACVIAASYEAKAHGVNVGMRLSEAKELIsDLITVETDPPKYHYvY 91
Cdd:cd01700 1 ALVDCNSFYASCERVFRPLLLGRPLVV---LSNNdGCVIARSPEAKALGIKMGSPYFKVPDLL-ERHGVAVFSSNYAL-Y 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 92 QQL-ARIMK---SYSPAVTMKSIDEGIIDFHGTRQAINkrpLTAIGYEIKQRLRDGVGcwMKCNIGIAPNRFLAKTAASL 167
Cdd:cd01700 76 GDMsRRIMSileRFSPDVEVYSIDESFLDLTGSLRFGD---LEELARKIRRRILQETG--IPVTVGIGPTKTLAKLANDL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 168 HK-----PDGLDVITHANLRQVLADLQLTDLTGIAERNQARLNACGIYTPLQFLDASAKVLKNQvFkSIIGEDWHQRLRG 242
Cdd:cd01700 151 AKkknpyGGVVDLTDEEVRDKLLKILPVGDVWGIGRRTAKKLNAMGIHTAGDLAQADPDLLRKK-F-GVVGERLVRELNG 228
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1084127881 243 W---EVDNHSWGTKSIG--RQFvMDDYHaSEETVRSRLALLCESTGLKMRHKGLCARGISIHLRY 302
Cdd:cd01700 229 IdclPLEEYPPPKKSIGssRSF-GRDVT-DLDELKQALAEYAERAAEKLRRQKSVARTISVFIGT 291
|
|
| PRK03858 |
PRK03858 |
DNA polymerase IV; Validated |
12-302 |
1.96e-36 |
|
DNA polymerase IV; Validated
Pssm-ID: 179663 [Multi-domain] Cd Length: 396 Bit Score: 135.11 E-value: 1.96e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 12 ILHIDLNSCFATVEQQARPLLRGRPLAVTnrltvNACVIAASYEAKAHGVNVGMRLSEAKELISDLITVetdPPKYHyVY 91
Cdd:PRK03858 6 ILHADLDSFYASVEQRDDPALRGRPVIVG-----GGVVLAASYEAKAYGVRTAMGGRQARRLCPQAVVV---PPRMS-AY 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 92 QQLAR----IMKSYSPAVTMKSIDEGIIDFHGTRQaINKRPLtAIGYEIKQRLRDGVGcwMKCNIGIAPNRFLAKTAASL 167
Cdd:PRK03858 77 SRASKavfeVFRDTTPLVEGLSIDEAFLDVGGLRR-ISGTPV-QIAARLRRRVREEVG--LPITVGVARTKFLAKVASQV 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 168 HKPDGLDVITHANLRQVLADLQLTDLTGIAERNQARLNACGIYTPLQFLDASAKVLknqvfKSIIGEDWHQRLR--GWEV 245
Cdd:PRK03858 153 AKPDGLLVVPPDRELAFLHPLPVRRLWGVGPVTAAKLRAHGITTVGDVAELPESAL-----VSLLGPAAGRHLHalAHNR 227
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1084127881 246 DNHSWGT----KSIGRQFVMDDYHASEETVRSRLALLCESTGLKMRHKGLCARGISIHLRY 302
Cdd:PRK03858 228 DPRRVETgrrrRSVGAQRALGRGPNSPAEVDAVVVALVDRVARRMRAAGRTGRTVVLRLRF 288
|
|
| PRK14133 |
PRK14133 |
DNA polymerase IV; Provisional |
12-304 |
3.82e-36 |
|
DNA polymerase IV; Provisional
Pssm-ID: 184529 [Multi-domain] Cd Length: 347 Bit Score: 133.30 E-value: 3.82e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 12 ILHIDLNSCFATVEQQARPLLRGRPLAV---TNRLTVNACviaaSYEAKAHGVNVGMRLSEAKELISDLITVETDPPKYH 88
Cdd:PRK14133 5 IIHVDMDAFFASVEQMDNPKLKGKPVIVggiSERGVVSTC----SYEARKYGVHSAMPVFMAKKRCPHGIFLPVRHERYK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 89 YVYQQLARIMKSYSPAVTMKSIDEGIIDFhgtrQAINKRPLTaIGYEIKQRLRDGVGcwMKCNIGIAPNRFLAKTAASLH 168
Cdd:PRK14133 81 EVSKNIFKILYEVTPIVEPVSIDEAYLDI----TNIKEEPIK-IAKYIKKKVKKETG--LTLSVGISYNKFLAKLASDWN 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 169 KPDGLDVITHANLRQVLADLQLTDLTGIAERNQARLNACGIYTPLQFLDASAKVLKNQVFKSiiGEDWHQRLRGweVDNH 248
Cdd:PRK14133 154 KPDGIKIITEDMIPDILKPLPISKVHGIGKKSVEKLNNIGIYTIEDLLKLSREFLIEYFGKF--GVEIYERIRG--IDYR 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 249 SWGT----KSIGRQFVMDDYHASEETVRSRLALLCESTGLKMRHKGLCARGISIHLRYKN 304
Cdd:PRK14133 230 EVEVsrerKSIGKETTLKKDTKDKEELKKYLKDFSNIISEELKKRNLYGKTVTVKIKTSD 289
|
|
| IMS |
pfam00817 |
impB/mucB/samB family; These proteins are involved in UV protection (Swiss). |
15-165 |
1.23e-35 |
|
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
Pssm-ID: 425885 [Multi-domain] Cd Length: 148 Bit Score: 126.15 E-value: 1.23e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 15 IDLNSCFATVEQQARPLLRGRPLAVTNRlTVNACVIAASYEAKAHGVNVGMRLSEAKELISDLITVETDPPKYHYVYQQL 94
Cdd:pfam00817 1 IDMDAFFASVELLRDPELKGKPVAVGGG-NGRGIVAAASYEARKYGVRSGMPVFEAKKLCPNLIVVPPDLELYRRASRKI 79
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1084127881 95 ARIMKSYSPAVTMK-SIDEGIIDFHGTRQaiNKRPLTAIGYEIKQRLRDGVGCwmKCNIGIAPNRFLAKTAA 165
Cdd:pfam00817 80 FEILRRFSTPKVEQaSIDEAFLDLTGLEK--LFGAEEALAKRLRREIAEETGL--TCSIGIAPNKLLAKLAS 147
|
|
| PRK02406 |
PRK02406 |
DNA polymerase IV; Validated |
20-306 |
2.03e-30 |
|
DNA polymerase IV; Validated
Pssm-ID: 235035 [Multi-domain] Cd Length: 343 Bit Score: 117.53 E-value: 2.03e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 20 CF-ATVEQQARPLLRGRPLAVTNRLTVNACVIAASYEAKAHGVNVGMRLSEAKELISDLITVETDPPKYHYVYQQLARIM 98
Cdd:PRK02406 3 CFyAAVEMRDNPELRGKPVAVGGSPGRRGVISTCNYEARKFGVRSAMPTAQALKLCPDLIFVPGRFDVYKEVSRQIREIF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 99 KSYSPAVTMKSIDEGIIDFhgTRqaiNKRPL---TAIGYEIKQRLRDGVGcwMKCNIGIAPNRFLAKTAASLHKPDGLDV 175
Cdd:PRK02406 83 RRYTDLIEPLSLDEAYLDV--TD---NKLCIgsaTLIAQEIRQDIFEELG--LTASAGVAPNKFLAKIASDWNKPNGLFV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 176 ITHANLRQVLADLQLTDLTGIAERNQARLNACGIYTPLQFLDASAKVLKNQVFKSiiGEDWHQRLRGweVDNH----SWG 251
Cdd:PRK02406 156 ITPEEVDAFLATLPVEKIPGVGKVTAEKLHALGIYTCADLQKYDLAELIRHFGKF--GRRLYERARG--IDERpvkpDRE 231
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 1084127881 252 TKSIG--RQFVMDDYhaSEETVRSRLALLCESTGLKMRHKGLCARGISIHLRYKNGD 306
Cdd:PRK02406 232 RKSVGveRTFAEDLY--DLEACLAELPRLAEKLERRLERAKPDKRIKTVGVKLKFAD 286
|
|
| PRK01216 |
PRK01216 |
DNA polymerase IV; Validated |
12-234 |
1.11e-29 |
|
DNA polymerase IV; Validated
Pssm-ID: 179251 [Multi-domain] Cd Length: 351 Bit Score: 116.04 E-value: 1.11e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 12 ILHIDLNSCFATVEQQARPLLRGRPLAV---TNRLTVNACVIAASYEAKAHGVNVGMRLSEAKELISDLITVetdpPKYH 88
Cdd:PRK01216 3 ILFVDFDYFFAQVEEVLNPSLKGKPVVVcvySGRFEDSGAVATANYEARKLGIKAGMPIVEAKKILPNAVYL----PMRK 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 89 YVYQQLA-RIMK---SYSPAVTMKSIDEGIIDFhgTRQAINKRPLTAIGYEIKQRLRDGVGcwMKCNIGIAPNRFLAKTA 164
Cdd:PRK01216 79 EVYQQVSnRIMKllrEYSEKIEIASIDEAYLDI--SDKVKNYQDAYNLGLEIKNKILEKEK--ITVTVGISKNKVFAKIA 154
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 165 ASLHKPDGLDVITHANLRQVLADLQLTDLTGIAERNQARLNACGIYTPLQFLDASAKVLKNqvfksIIGE 234
Cdd:PRK01216 155 ADMAKPNGIKVIDDEEVKRFINELDIADIPGIGDITAEKLKKLGVNKLVDTLRIEFDELKG-----IIGE 219
|
|
| PRK03348 |
PRK03348 |
DNA polymerase IV; Provisional |
8-243 |
1.04e-28 |
|
DNA polymerase IV; Provisional
Pssm-ID: 235118 [Multi-domain] Cd Length: 454 Bit Score: 115.03 E-value: 1.04e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 8 ESPQILHIDLNSCFATVEQQARPLLRGRPLAVTNrLTVNACVIAASYEAKAHGVNVGMRLSEAKELISDLITVEtdPPKY 87
Cdd:PRK03348 3 AQRWVLHLDMDAFFASVEQLTRPTLRGRPVLVGG-LGGRGVVAGASYEARVFGARSAMPMHQARRLVGNGAVVL--PPRF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 88 HyVYQQLAR----IMKSYSPAVTMKSIDEGIIDFHGTrQAINKRPLTAIGYEIKQRLRDGVGcwMKCNIGIAPNRFLAKT 163
Cdd:PRK03348 80 V-VYRAASRrvfdTLRELSPVVEQLSFDEAFVEPAEL-AGASAEEVEAFAERLRARVREETG--LPASVGAGSGKQIAKI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 164 AASLHKPDGLDVITHANLRQVLADLQLTDLTGIAERNQARLNACGIYTPLQFLDASAKVLKNQVFKSiIGEDWHQRLRGW 243
Cdd:PRK03348 156 ASGLAKPDGIRVVPPGEERELLAPLPVRRLWGIGPVTEEKLHRLGIETIGDLAALSEAEVANLLGAT-VGPALHRLARGI 234
|
|
| PolY_Rev1 |
cd01701 |
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. ... |
12-246 |
3.00e-27 |
|
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Rev1 has both structural and enzymatic roles. Structurally, it is believed to interact with other nonclassical polymerases and replication machinery to act as a scaffold. Enzymatically, it catalyzes the specific insertion of dCMP opposite abasic sites. Rev1 interacts with the Rev7 subunit of the B-family TLS polymerase Pol zeta (Rev3/Rev7). Rev1 is known to actively promote the introduction of mutations, potentially making it a significant target for cancer treatment.
Pssm-ID: 176455 [Multi-domain] Cd Length: 404 Bit Score: 110.10 E-value: 3.00e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 12 ILHIDLNSCFATVEQQARPLLRGRPLAVTNRLTVNACVIAASYEAKAHGVNVGMRLSEAKELISDLITVETDPPKYHYVY 91
Cdd:cd01701 49 IMHVDFDCFFVSVSIRNRPDLKGKPVAVCHGKGPNSEIASCNYEARSYGIKNGMWVGQAKKLCPQLVTLPYDFEAYEEVS 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 92 QQLARIMKSYSPAVTMKSIDEGIIDFHGTRQAINKrPLTAIGYEIKQRLRDGVGCwmKCNIGIAPNRFLAKTAASLHKPD 171
Cdd:cd01701 129 LTFYEILASYTDNIEAVSCDEALIDITSLLEETYE-LPEELAEAIRNEIRETTGC--SASVGIGPNILLARLATRKAKPD 205
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1084127881 172 GLDVITHANLRQVLADLQLTDLTGIAERNQARLNACGIYTPLQFLDASAKVLKNQ-VFKSIIGEDWHQRLRGWEVD 246
Cdd:cd01701 206 GQYHLSAEKVEEFLSQLKVGDLPGVGSSLAEKLVKLFGDTCGGLELRSKTKEKLQkVLGPKTGEKLYDYCRGIDDR 281
|
|
| PRK02794 |
PRK02794 |
DNA polymerase IV; Provisional |
12-301 |
1.62e-26 |
|
DNA polymerase IV; Provisional
Pssm-ID: 179473 [Multi-domain] Cd Length: 419 Bit Score: 108.48 E-value: 1.62e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 12 ILHIDLNSCFATVEQQARPLLRGRPLAVTN-RLTVnacVIAASYEAKAHGVNVGMRLSEAKELISDLITVETDPPKYHYV 90
Cdd:PRK02794 38 IAHIDCDAFYASVEKRDNPELRDKPVIIGGgKRGV---VSTACYIARIHGVRSAMPMFKALKLCPDAVVIKPDMEKYVRV 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 91 YQQLARIMKSYSPAVTMKSIDEGIIDFHGTrQAINKRPLTAIGYEIKQRLRDGVGcwMKCNIGIAPNRFLAKTAASLHKP 170
Cdd:PRK02794 115 GREVRAMMQALTPLVEPLSIDEAFLDLSGT-ERLHGAPPAVVLARFARRVEREIG--ITVSVGLSYNKFLAKIASDLDKP 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 171 DGLDVITHANLRQVLADLQLTDLTGIAERNQARLNACGIYTPLQFLDASAKVLKNQvFKSiIGEDWHQRLRGWE---VDN 247
Cdd:PRK02794 192 RGFSVIGRAEALAFLAPKPVGIIWGVGPATAARLARDGIRTIGDLQRADEADLMRR-FGS-MGLRLWRLARGIDdrkVSP 269
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 1084127881 248 HSwGTKSIGRQFVMDDYHASEETVRSRLALLCESTGLKMRHKGLCARGISIHLR 301
Cdd:PRK02794 270 DR-EAKSVSAETTFETDLSDFEDLEPILWRLSEKVSRRLKAAGLAGRTVTLKLK 322
|
|
| PRK03352 |
PRK03352 |
DNA polymerase IV; Validated |
12-223 |
1.01e-23 |
|
DNA polymerase IV; Validated
Pssm-ID: 179564 [Multi-domain] Cd Length: 346 Bit Score: 99.33 E-value: 1.01e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 12 ILHIDLNSCFATVEQQARPLLRGRPLAV------TNRLTVNACviaASYEAKAHGVNVGMRLSEAKELISDLITVETDPP 85
Cdd:PRK03352 7 VLHVDLDQFIAAVELLRRPELAGLPVIVggngdpTEPRKVVTC---ASYEARAFGVRAGMPLRTAARRCPDAVFLPSDPA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 86 KYHYVYQQLARIMKSYSPAVTMKSIDEGiidFHGTRQAinkRPlTAIGYEIKQRLRDGVGcwMKCNIGIAPNRFLAKTAA 165
Cdd:PRK03352 84 AYDAASEEVMATLRDLGVPVEVWGWDEA---FLGVDTD---DP-EALAEEIRAAVLERTG--LSCSVGIGDNKLRAKIAT 154
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1084127881 166 SLHKPDGLDVITHANLRQVLADLQLTDLTGIAERNQARLNACGIYTPLQFLDASAKVL 223
Cdd:PRK03352 155 GFAKPAGVFRLTDANWMAVMGDRPTDALWGVGPKTAKRLAALGITTVADLAAADPAEL 212
|
|
| PolY_Pol_eta |
cd01702 |
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. ... |
14-195 |
1.16e-22 |
|
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Unlike other Y-family members, Pol eta can efficiently and accurately replicate DNA past UV-induced lesions. Its activity is initiated by two simultaneous interactions: the PIP box in pol eta interacting with PCNA, and the UBZ (ubiquitin-binding zinc finger) in pol eta interacting with monoubiquitin attached to PCNA. Pol eta is more efficient in copying damaged DNA than undamaged DNA and seems to recognize when a lesion has been passed, facilitating a lesion-dependent dissociation from the DNA.
Pssm-ID: 176456 [Multi-domain] Cd Length: 359 Bit Score: 96.61 E-value: 1.16e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 14 HIDLNSCFATVEQQARPLLRGRPLAVTNRLTVnacvIAASYEAKAHGVNVGMRLSEAKELISDLITVET-------DPPK 86
Cdd:cd01702 2 HIDMDAFFAQVEQVRLGLLRNDPVAVVQWNSI----IAVSYAARAFGVTRFMTIDEAKKKCPDLILAHVatykkgeDEAD 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 87 YHY------------VYQ----QLARIMKSYSPAVTMKSIDEGIIDfhgtrqainkrpltaIGYEIKQRLRDGVGCWMK- 149
Cdd:cd01702 78 YHEnpsparhkvsldPYRrasrKILNILKRFGDVVEKASIDEAYLD---------------LGSRIVEEIRQQVYDELGy 142
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 1084127881 150 -CNIGIAPNRFLAKTAASLHKPDGLDVITHANLRQVLADLQLTDLTG 195
Cdd:cd01702 143 tCSAGIAHNKMLAKLASGMNKPNAQTILRNDAVASFLSSLPITSIRG 189
|
|
| PolY_Pol_iota |
cd01703 |
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. ... |
13-242 |
7.94e-22 |
|
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying efficiency for different template nucleotides.
Pssm-ID: 176457 [Multi-domain] Cd Length: 379 Bit Score: 94.84 E-value: 7.94e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 13 LHIDLNSCFATVEQQARPLLRGRPLAVTNRLTVNACviaaSYEAKAHGVNVGMRLSEAKELISDLITVE-TDPPKYHYVY 91
Cdd:cd01703 1 IHLDLDCFYAQVEEIRDPSLKSKPLGIQQKYIVVTC----NYEARRLGVKKLMSIKDAKEICPDLVLVNgEDLTPFRDMS 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 92 QQLARIMKSYSPA--VTMKSIDEGIIDFHGTRQAINKRpltaIGYEIKQRLRDGVGcwMKCNIGIAPNRFLAKTAASLHK 169
Cdd:cd01703 77 KKVYRLLRSYSWNdrVERLGFDENFMDVTEMRLLVASH----IAYEMRERIENELG--LTCCAGIASNKLLAKLVGSVNK 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 170 PDGLDVITHANLRQVLADLQLTDL---TGIAERNQARLNACGI----------YTPLQFLDASAKVLKNQVFKSIIGEDW 236
Cdd:cd01703 151 PNQQTTLLPPSCADLMDFMDLHDLrkiPGIGYKTAAKLEAHGIssvrdlqefsNRNRQTVGAAPSLLELLLMVKEFGEGI 230
|
....*.
gi 1084127881 237 HQRLRG 242
Cdd:cd01703 231 GQRIWK 236
|
|
| umuC |
PRK03609 |
translesion error-prone DNA polymerase V subunit UmuC; |
14-224 |
8.51e-20 |
|
translesion error-prone DNA polymerase V subunit UmuC;
Pssm-ID: 179607 [Multi-domain] Cd Length: 422 Bit Score: 89.44 E-value: 8.51e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 14 HIDLNSCFATVEQQARPLLRGRPLAVtnrLTVN-ACVIAASYEAKAHGVNVGMRLSEAKELI--SDLITVETDPPKYHYV 90
Cdd:PRK03609 4 LCDVNSFYASCETVFRPDLRGKPVVV---LSNNdGCVIARSAEAKALGIKMGDPWFKQKDLFrrCGVVCFSSNYELYADM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 91 YQQLARIMKSYSPAVTMKSIDEGIIDFHGTRqaiNKRPLTAIGYEIKQRLRDGVGcwMKCNIGIAPNRFLAKTAASLHK- 169
Cdd:PRK03609 81 SNRVMSTLEELSPRVEIYSIDEAFCDLTGVR---NCRDLTDFGREIRATVLQRTH--LTVGVGIAQTKTLAKLANHAAKk 155
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 170 --PDGLDVITHANL---RQVLADLQLTDLTGIAERNQARLNACGIYTPLQFLDASAKVLK 224
Cdd:PRK03609 156 wqRQTGGVVDLSNLerqRKLLSLQPVEEVWGVGRRISKKLNAMGIKTALDLADTNIRFIR 215
|
|
| PTZ00205 |
PTZ00205 |
DNA polymerase kappa; Provisional |
13-314 |
3.94e-14 |
|
DNA polymerase kappa; Provisional
Pssm-ID: 140232 [Multi-domain] Cd Length: 571 Bit Score: 72.74 E-value: 3.94e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 13 LHIDLNSCFATVEQQARPLLRGRPLAV--TNRLTvnacviAASYEAKAHGVNVGMRLSEAKELISDLITVETDPPKYHYV 90
Cdd:PTZ00205 136 IHLDMDMFYAAVEIKKHPEYAAIPLAIgtMTMLQ------TANYVARGRGIRQGMPGFLALKICPNLLILPPDFDAYNEE 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 91 YQQLARIMKSYSPAVTMKSIDEGIID-------FHGTRQAINkrpltaIGYEIKQRLRDGVGcwMKCNIGIAPNRFLAKT 163
Cdd:PTZ00205 210 SNTVRRIVAEYDPNYISFGLDELTLEvsayierFEGTKTAED------VASELRVRVFGETK--LTASAGIGPTAALAKI 281
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 164 AASLHKPDG---LDVITHANLRQVLADLQLTDLTGIAERNQARLNACGIYTPLQFLDASAK---VLKNQVFKSIIGED-- 235
Cdd:PTZ00205 282 ASNINKPNGqhdLNLHTRGDVMTYVRDLGLRSVPGVGKVTEALLKGLGITTLSDIYNRRVElcyILHNNLFRFLLGASig 361
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 236 ---WHQRLRGWEVDNHSWGT----KSIGRQFVMDDYHASEEtVRSRLALLCESTGLKMRHKGLCARGISIHLRYKNGDHW 308
Cdd:PTZ00205 362 imqWPDAATAANTENCEGATggqrKAISSERSFTTPRTKEG-LQEMVDTVFNGAYEEMRKSELMCRQISLTIRWASYRYQ 440
|
....*.
gi 1084127881 309 QARKAF 314
Cdd:PTZ00205 441 QYTKSL 446
|
|
| PolY_like |
cd03468 |
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that ... |
26-308 |
7.35e-13 |
|
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176458 [Multi-domain] Cd Length: 335 Bit Score: 68.18 E-value: 7.35e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 26 QQARPLLRGRPLAVTNRlTVNACVIAASYEAKAHGVNVGMRLSEAKELISDLITVETDPPKYHYVYQQLARIMKSYSPAV 105
Cdd:cd03468 14 LRNRPADDEAPLAVVER-KKAGRILACNAAARAAGVRPGMPLAEALALCPNLQVVEYDPEADARALQELALWLLRFTPLV 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 106 TMKSIDEGIIDFHGtrqainkrPLTAIGYEIK--QRLRD-----GVGCWmkcnIGIAPNRFLAKTAASLHKPDGLDVITH 178
Cdd:cd03468 93 ALDGPDGLLLDVTG--------CLHLFGGEDAlaASLRAalatlGLSAR----AGIADTPGAAWLLARAGGGRGVLRREA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 179 ANLRQVLADLQLTDLTGIAERNQARLNACGIYTPLQFLDAS----AKVLKNQvfksiiGEDWHQRLRGWEVDNHSWGTK- 253
Cdd:cd03468 161 LAAALVLLAPLPVAALRLPPETVELLARLGLRTLGDLAALPraelARRFGLA------LLLRLDQAYGRDPEPLLFSPPp 234
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084127881 254 -----SIGRQFVMDDYHASEETVRSRLALLCesTGLKMRHKGlcARGISIHLRYKNGDHW 308
Cdd:cd03468 235 pafdfRLELQLEEPIARGLLFPLRRLLEQLC--AFLALRGLG--ARRLSLTLFREDGRVT 290
|
|
| IMS_C |
pfam11799 |
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss). |
253-326 |
4.24e-06 |
|
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).
Pssm-ID: 463354 [Multi-domain] Cd Length: 104 Bit Score: 44.86 E-value: 4.24e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1084127881 253 KSIGRQFVMDDYHASEETVRSRLALLCESTGLKMRHKGLCARGISIHLRYKNGDHWQARKAFRSTFFSNGEIYR 326
Cdd:pfam11799 2 KSIGAERTFGRDLTDLEELREALLELAEELAERLRRQGLVARTVTVKIRYSDFRTITRSVTLPSPTDDTDEIYR 75
|
|
| |
