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Conserved domains on  [gi|1084452928|gb|OGN19388|]
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MAG: hypothetical protein A3F50_00570 [Candidatus Yanofskybacteria bacterium RIFCSPHIGHO2_12_FULL_44_29b]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG3177 COG3177
Fic family protein [Transcription];
86-306 1.29e-45

Fic family protein [Transcription];


:

Pssm-ID: 442410 [Multi-domain]  Cd Length: 316  Bit Score: 156.77  E-value: 1.29e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084452928  86 IREIISNPDVKDQFYLSL----TYNTNRIEGSSLTEGETAEILfENAALKNKSLAEQLEAKNHQAALIYLFEHISHGEIN 161
Cdd:COG3177    15 LGRLDGLPEELRELLRKLlieeAYASSAIEGNTLTLDEVRSLL-EGGLTGGPPLRDEREVLNYVEALEYLLELLRGEPLT 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084452928 162 EQFILKLHSILLN---AVRSDAGTYRKHSVRILGTDVPTANFlKIPDLIKQLILDIN-KNETDIFTQIAATHARFEQIHP 237
Cdd:COG3177    94 EELILELHRILLKglrGEDKEPGEYRTGQVGIGAVYVPPPPE-EVPELMEELLDWLNeEDELHPLIKAAIAHYQFETIHP 172

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1084452928 238 FGDGNGRIGRLLMHAMALKRN------FPPMVIYQSKKIIYKNRLYSAQMNNDLLPLAGLICDATLEGYRILERK 306
Cdd:COG3177   173 FADGNGRTGRLLMNLLLLRAGllsqplLPLSRIIEEDRDEYYDALEAVRETGDLTPWIEFFLEAILEAAEEALAL 247
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
15-52 2.64e-06

Helix-turn-helix XRE-family like proteins;


:

Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 44.05  E-value: 2.64e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1084452928   15 GVTQEEMAHKLGVTFASLNRWINEKSKPRAKMLEKIER 52
Cdd:smart00530  10 GLTQEELAEKLGVSRSTLSRIENGKRKPSLETLKKLAK 47
 
Name Accession Description Interval E-value
COG3177 COG3177
Fic family protein [Transcription];
86-306 1.29e-45

Fic family protein [Transcription];


Pssm-ID: 442410 [Multi-domain]  Cd Length: 316  Bit Score: 156.77  E-value: 1.29e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084452928  86 IREIISNPDVKDQFYLSL----TYNTNRIEGSSLTEGETAEILfENAALKNKSLAEQLEAKNHQAALIYLFEHISHGEIN 161
Cdd:COG3177    15 LGRLDGLPEELRELLRKLlieeAYASSAIEGNTLTLDEVRSLL-EGGLTGGPPLRDEREVLNYVEALEYLLELLRGEPLT 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084452928 162 EQFILKLHSILLN---AVRSDAGTYRKHSVRILGTDVPTANFlKIPDLIKQLILDIN-KNETDIFTQIAATHARFEQIHP 237
Cdd:COG3177    94 EELILELHRILLKglrGEDKEPGEYRTGQVGIGAVYVPPPPE-EVPELMEELLDWLNeEDELHPLIKAAIAHYQFETIHP 172

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1084452928 238 FGDGNGRIGRLLMHAMALKRN------FPPMVIYQSKKIIYKNRLYSAQMNNDLLPLAGLICDATLEGYRILERK 306
Cdd:COG3177   173 FADGNGRTGRLLMNLLLLRAGllsqplLPLSRIIEEDRDEYYDALEAVRETGDLTPWIEFFLEAILEAAEEALAL 247
Fic pfam02661
Fic/DOC family; This family consists of the Fic (filamentation induced by cAMP) protein and ...
 160-254 2.77e-19

Fic/DOC family; This family consists of the Fic (filamentation induced by cAMP) protein and doc (death on curing). The Fic protein is involved in cell division and is suggested to be involved in the synthesis of PAB or folate, indicating that the Fic protein and cAMP are involved in a regulatory mechanism of cell division via folate metabolism. This family contains a central conserved motif HPFXXGNG in most members. The exact molecular function of these proteins is uncertain. P1 lysogens of Escherichia coli carry the prophage as a stable low copy number plasmid. The frequency with which viable cells cured of prophage are produced is about 10(-5) per cell per generation. A significant part of this remarkable stability can be attributed to a plasmid-encoded mechanism that causes death of cells that have lost P1. In other words, the lysogenic cells appear to be addicted to the presence of the prophage. The plasmid withdrawal response depends on a gene named doc (death on curing) that is represented by this family. Doc induces a reversible growth arrest of E. coli cells by targetting the protein synthesis machinery. Doc hosts the C-terminal domain of its antitoxin partner Phd (prevents host death) through fold complementation, a domain that is intrinsically disordered in solution but that folds into an alpha-helix on binding to Doc.This domain forms complexes with Phd antitoxins containing pfam02604.


Pssm-ID: 426907  Cd Length: 94  Bit Score: 80.97  E-value: 2.77e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084452928 160 INEQFILKLHSILLnAVRSDAGTYRKHSVRIlGTDVPTANFLKIPDLIKQLILDINKNETDIFTQIAATHARFEQIHPFG 239
Cdd:pfam02661   2 LDLEDLLALHRLLI-ERHGGAGGARDVNVSG-LLESALARPEQIPFGLEELLLYPDLDREHPLEKAAALHFGFAKIHPFR 79

                          90
                  ....*....|....*
gi 1084452928 240 DGNGRIGRLLMHAMA 254
Cdd:pfam02661  80 DGNGRTARLLANLFL 94
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
15-52 2.64e-06

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 44.05  E-value: 2.64e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1084452928   15 GVTQEEMAHKLGVTFASLNRWINEKSKPRAKMLEKIER 52
Cdd:smart00530  10 GLTQEELAEKLGVSRSTLSRIENGKRKPSLETLKKLAK 47
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
1-54 5.13e-06

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 43.30  E-value: 5.13e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1084452928   1 MNIKEKLLLIQKISGVTQEEMAHKLGVTFASLNRWINEKSKPRAKMLEKIERMY 54
Cdd:COG1476     3 KKLGNRLKELRKERGLTQEELAELLGVSRQTISAIENGKYNPSLELALKIARAL 56
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 15-54 5.48e-06

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 42.93  E-value: 5.48e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1084452928  15 GVTQEEMAHKLGVTFASLNRWINEKSKPRAKMLEKIERMY 54
Cdd:cd00093    12 GLTQEELAEKLGVSRSTISRIENGKRNPSLETLEKLAKAL 51
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 15-54 1.36e-05

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 41.76  E-value: 1.36e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1084452928  15 GVTQEEMAHKLGVTFASLNRWINEKSKPRAKMLEKIERMY 54
Cdd:pfam01381   9 GLSQEELAEKLGVSRSTISKIENGKREPSLETLKKLAEAL 48
mob_myst_B TIGR02613
mobile mystery protein B; Members of this protein family, which we designate mobile mystery ...
 137-261 1.84e-04

mobile mystery protein B; Members of this protein family, which we designate mobile mystery protein B, are found in mobization-related contexts more often than not, including within a CRISPR-associated gene region in Geobacter sulfurreducens PCA, and on plasmids in Agrobacterium tumefaciens and Coxiella burnetii, always together with mobile mystery protein A (TIGR02612), a member of the family of helix-turn-helix DNA binding proteins (pfam01381). This protein is encoded by the downstream member of the gene pair and belongs to the Fic protein family (pfam02661), where Fic (filamentation induced by cAMP) is a regulator of cell division. The characteristics of having a two-gene operon in a varied context and often on plasmids, with one member affecting cell division and the other able to bind DNA, suggests similarity to addiction modules.


Pssm-ID: 131662  Cd Length: 186  Bit Score: 41.74  E-value: 1.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084452928 137 EQLEAKNHQAALIYLFEHISHGE--INEQFILKLHSILLNAVRSDAGTYRKHSVRIlGTDvptanFLKIPDLIKQLILDI 214
Cdd:TIGR02613  24 DEFEQANIAEGILWAEGRRRKKKdiLSETFLRRLHRRMFGDVWRWAGDFRTTQKNI-GVS-----PLQIPSELAILLDDV 97

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1084452928 215 N---KNETDIFTQIAAT-HARFEQIHPFGDGNGRIGRLLMHAMALKRNFPP 261
Cdd:TIGR02613  98 RywlQNGTFSPDEIAIRfHHRLVAIHPFPNGNGRHARLATDLLLEQQGYSP 148
 
Name Accession Description Interval E-value
COG3177 COG3177
Fic family protein [Transcription];
86-306 1.29e-45

Fic family protein [Transcription];


Pssm-ID: 442410 [Multi-domain]  Cd Length: 316  Bit Score: 156.77  E-value: 1.29e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084452928  86 IREIISNPDVKDQFYLSL----TYNTNRIEGSSLTEGETAEILfENAALKNKSLAEQLEAKNHQAALIYLFEHISHGEIN 161
Cdd:COG3177    15 LGRLDGLPEELRELLRKLlieeAYASSAIEGNTLTLDEVRSLL-EGGLTGGPPLRDEREVLNYVEALEYLLELLRGEPLT 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084452928 162 EQFILKLHSILLN---AVRSDAGTYRKHSVRILGTDVPTANFlKIPDLIKQLILDIN-KNETDIFTQIAATHARFEQIHP 237
Cdd:COG3177    94 EELILELHRILLKglrGEDKEPGEYRTGQVGIGAVYVPPPPE-EVPELMEELLDWLNeEDELHPLIKAAIAHYQFETIHP 172

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1084452928 238 FGDGNGRIGRLLMHAMALKRN------FPPMVIYQSKKIIYKNRLYSAQMNNDLLPLAGLICDATLEGYRILERK 306
Cdd:COG3177   173 FADGNGRTGRLLMNLLLLRAGllsqplLPLSRIIEEDRDEYYDALEAVRETGDLTPWIEFFLEAILEAAEEALAL 247
Fic pfam02661
Fic/DOC family; This family consists of the Fic (filamentation induced by cAMP) protein and ...
 160-254 2.77e-19

Fic/DOC family; This family consists of the Fic (filamentation induced by cAMP) protein and doc (death on curing). The Fic protein is involved in cell division and is suggested to be involved in the synthesis of PAB or folate, indicating that the Fic protein and cAMP are involved in a regulatory mechanism of cell division via folate metabolism. This family contains a central conserved motif HPFXXGNG in most members. The exact molecular function of these proteins is uncertain. P1 lysogens of Escherichia coli carry the prophage as a stable low copy number plasmid. The frequency with which viable cells cured of prophage are produced is about 10(-5) per cell per generation. A significant part of this remarkable stability can be attributed to a plasmid-encoded mechanism that causes death of cells that have lost P1. In other words, the lysogenic cells appear to be addicted to the presence of the prophage. The plasmid withdrawal response depends on a gene named doc (death on curing) that is represented by this family. Doc induces a reversible growth arrest of E. coli cells by targetting the protein synthesis machinery. Doc hosts the C-terminal domain of its antitoxin partner Phd (prevents host death) through fold complementation, a domain that is intrinsically disordered in solution but that folds into an alpha-helix on binding to Doc.This domain forms complexes with Phd antitoxins containing pfam02604.


Pssm-ID: 426907  Cd Length: 94  Bit Score: 80.97  E-value: 2.77e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084452928 160 INEQFILKLHSILLnAVRSDAGTYRKHSVRIlGTDVPTANFLKIPDLIKQLILDINKNETDIFTQIAATHARFEQIHPFG 239
Cdd:pfam02661   2 LDLEDLLALHRLLI-ERHGGAGGARDVNVSG-LLESALARPEQIPFGLEELLLYPDLDREHPLEKAAALHFGFAKIHPFR 79

                          90
                  ....*....|....*
gi 1084452928 240 DGNGRIGRLLMHAMA 254
Cdd:pfam02661  80 DGNGRTARLLANLFL 94
FIDO COG2184
Fido, protein-threonine AMPylation domain [Signal transduction mechanisms];
119-299 1.26e-13

Fido, protein-threonine AMPylation domain [Signal transduction mechanisms];


Pssm-ID: 441787 [Multi-domain]  Cd Length: 196  Bit Score: 68.03  E-value: 1.26e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084452928 119 ETAEILFENAALKNKSLAEQLEAKNHQAALIYLFEHISHGEINEQFILKLHSILLNAVRSDAGTYRKHSVRILGTdvPTA 198
Cdd:COG2184    10 PGTTVLRNKLGITDAAELDEAEAELTALRAAELFERPPPGVFDLAHLKAIHRRLFGDVYDWAGQIRTVNISKGGT--RFA 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084452928 199 NFLKIPDLIKQLILDINKN------ETDIFTQIAAT-HARFEQIHPFGDGNGRIGRLLMHAMALKRNFpPMVIYQSKKII 271
Cdd:COG2184    88 PPSFIERELEALFDDLREEnylrglDREEFAERLARfHGELNVIHPFREGNGRTQRLFFDQLARQAGY-PLDWSRVDKEE 166

                         170       180
                  ....*....|....*....|....*...
gi 1084452928 272 YKNRLYSAqMNNDLLPLAGLICDATLEG 299
Cdd:COG2184   167 YLEALIAA-DNGDYSPLKALFRDALTPA 193
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
15-52 2.64e-06

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 44.05  E-value: 2.64e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1084452928   15 GVTQEEMAHKLGVTFASLNRWINEKSKPRAKMLEKIER 52
Cdd:smart00530  10 GLTQEELAEKLGVSRSTLSRIENGKRKPSLETLKKLAK 47
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
1-54 5.13e-06

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 43.30  E-value: 5.13e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1084452928   1 MNIKEKLLLIQKISGVTQEEMAHKLGVTFASLNRWINEKSKPRAKMLEKIERMY 54
Cdd:COG1476     3 KKLGNRLKELRKERGLTQEELAELLGVSRQTISAIENGKYNPSLELALKIARAL 56
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 15-54 5.48e-06

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 42.93  E-value: 5.48e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1084452928  15 GVTQEEMAHKLGVTFASLNRWINEKSKPRAKMLEKIERMY 54
Cdd:cd00093    12 GLTQEELAEKLGVSRSTISRIENGKRNPSLETLEKLAKAL 51
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
1-50 9.75e-06

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 43.06  E-value: 9.75e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1084452928   1 MNIKEKLLLIQKISGVTQEEMAHKLGVTFASLNRWINEKSKPRAKMLEKI 50
Cdd:COG1396     6 KALGERLRELRKARGLTQEELAERLGVSRSTISRIERGRRNPSLETLLKL 55
aMBF1 COG1813
Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and ...
 15-52 1.36e-05

Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441418 [Multi-domain]  Cd Length: 70  Bit Score: 42.23  E-value: 1.36e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1084452928  15 GVTQEEMAHKLGVTFASLNRWINEKSKPRAKMLEKIER 52
Cdd:COG1813    25 GLSQEELAEKLGVSESTIRRIERGEATPSLDTLRKLEK 62
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 15-54 1.36e-05

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 41.76  E-value: 1.36e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1084452928  15 GVTQEEMAHKLGVTFASLNRWINEKSKPRAKMLEKIERMY 54
Cdd:pfam01381   9 GLSQEELAEKLGVSRSTISKIENGKREPSLETLKKLAEAL 48
YiaG COG2944
DNA-binding transcriptional regulator YiaG, XRE-type HTH domain [Transcription];
15-53 1.41e-04

DNA-binding transcriptional regulator YiaG, XRE-type HTH domain [Transcription];


Pssm-ID: 442187 [Multi-domain]  Cd Length: 64  Bit Score: 39.15  E-value: 1.41e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1084452928  15 GVTQEEMAHKLGVTFASLNRWINEKSKPRA---KMLEKIERM 53
Cdd:COG2944    19 GLSQAEFAALLGVSVSTVRRWEQGRRKPSGaalKLLRLLEKH 60
mob_myst_B TIGR02613
mobile mystery protein B; Members of this protein family, which we designate mobile mystery ...
 137-261 1.84e-04

mobile mystery protein B; Members of this protein family, which we designate mobile mystery protein B, are found in mobization-related contexts more often than not, including within a CRISPR-associated gene region in Geobacter sulfurreducens PCA, and on plasmids in Agrobacterium tumefaciens and Coxiella burnetii, always together with mobile mystery protein A (TIGR02612), a member of the family of helix-turn-helix DNA binding proteins (pfam01381). This protein is encoded by the downstream member of the gene pair and belongs to the Fic protein family (pfam02661), where Fic (filamentation induced by cAMP) is a regulator of cell division. The characteristics of having a two-gene operon in a varied context and often on plasmids, with one member affecting cell division and the other able to bind DNA, suggests similarity to addiction modules.


Pssm-ID: 131662  Cd Length: 186  Bit Score: 41.74  E-value: 1.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084452928 137 EQLEAKNHQAALIYLFEHISHGE--INEQFILKLHSILLNAVRSDAGTYRKHSVRIlGTDvptanFLKIPDLIKQLILDI 214
Cdd:TIGR02613  24 DEFEQANIAEGILWAEGRRRKKKdiLSETFLRRLHRRMFGDVWRWAGDFRTTQKNI-GVS-----PLQIPSELAILLDDV 97

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1084452928 215 N---KNETDIFTQIAAT-HARFEQIHPFGDGNGRIGRLLMHAMALKRNFPP 261
Cdd:TIGR02613  98 RywlQNGTFSPDEIAIRfHHRLVAIHPFPNGNGRHARLATDLLLEQQGYSP 148
AF2118 COG3620
Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain ...
 1-53 5.90e-04

Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain CBS pair) [Transcription];


Pssm-ID: 442838 [Multi-domain]  Cd Length: 95  Bit Score: 38.46  E-value: 5.90e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1084452928   1 MNIKEKLLLIQKISGVTQEEMAHKLGVTFASLNRWINEKSKPRAKMLEKIERM 53
Cdd:COG3620    16 DTLGEALRLMRKELGLSQLPVAELVGVSQSDILRIESGKRDPTVSTLEKIAEA 68
HTH_19 pfam12844
Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. ...
 5-50 3.12e-03

Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. This family contains many example antitoxins from bacterial toxin-antitoxin systems. These antitoxins are likely to be DNA-binding domains.


Pssm-ID: 463728 [Multi-domain]  Cd Length: 64  Bit Score: 35.34  E-value: 3.12e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1084452928   5 EKLLLIQKISGVTQEEMAHKLGVTFASLNRWINEKSKPRAKMLEKI 50
Cdd:pfam12844   2 ERLRKAREERGLTQEELAERLGISRSQLSAIENGKSVPPAETLYKI 47
YdaS COG4197
DNA-binding transcriptional regulator YdaS, prophage-encoded, Cro superfamily [Transcription];
18-52 5.65e-03

DNA-binding transcriptional regulator YdaS, prophage-encoded, Cro superfamily [Transcription];


Pssm-ID: 443351  Cd Length: 68  Bit Score: 34.89  E-value: 5.65e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1084452928  18 QEEMAHKLGVTFASLNRWINEKSKPRAKMLEKIER 52
Cdd:COG4197    11 QSALARALGVSQQAVSQWLNGKRRVPAERCLAIER 45
VapI COG3093
Plasmid maintenance system antidote protein VapI, contains XRE-type HTH domain [Defense ...
 3-52 5.92e-03

Plasmid maintenance system antidote protein VapI, contains XRE-type HTH domain [Defense mechanisms];


Pssm-ID: 442327 [Multi-domain]  Cd Length: 87  Bit Score: 35.17  E-value: 5.92e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1084452928   3 IKEKLLliqKISGVTQEEMAHKLGVTFASLNRWINEKSKPRAKMLEKIER 52
Cdd:COG3093    13 LREEFL---EPLGLSQTELAKALGVSRQRISEILNGKRAITADTALRLAR 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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