NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1208037337|gb|OWK63649|]
View 

Plexin-B1 [Lonchura striata]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Sema_plexin_B1 cd11275
The Sema domain, a protein interacting module, of Plexin B1; Plexin B1 serves as the ...
 27-489 0e+00

The Sema domain, a protein interacting module, of Plexin B1; Plexin B1 serves as the Semaphorin 4D receptor and functions as a regulator of developing neurons and a tumor suppressor protein for melanoma. The Sema4D-plexin B signaling complex regulates dendritic and axonal complexity. The activation of Plexin B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. As a tumor suppressor, plexin B1 abrogates activation of the oncogenic receptor, c-Met, by its ligand, hepatocyte growth factor (HGF), in melanoma. Furthermore, plexin B1 suppresses integrin-dependent migration and activation of pp125FAK and inhibits Rho activity. Plexin B1 is highly expressed in endothelial cells and its activation by Sema4D elicits a potent proangiogenic response. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


:

Pssm-ID: 200536 [Multi-domain]  Cd Length: 461  Bit Score: 936.69  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337   27 FSHNATKFLHLSMDSESGTIYLGATNFLFQLTSDLLLENMVQTGPVLDSKDCLPPVSKLECPQAHHTDNHNKLLLVNTVQ 106
Cdd:cd11275      1 FSPNGTKFLHLSMDPESGTLYLGATNFLFQLTPDLLLENMVQTGPVLDSKDCLPPVSKLECPQAQHTNNHNKLLLVNPVQ 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  107 KELIVCGSVHQGICEKRSLASIDHVLFRPESPGDTQYVAANDPNITTVGLIAYSKDEVPLLFVGRGYTSRGVGGGIPPIT 186
Cdd:cd11275     81 KELIVCGSVHQGICEKRRLGSIDHVLFRPERPGDTQYVAANDPNVTTVGLVAYSKDGVPLLFVGRGYTSRGVGGGIPPIT 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  187 TRNLRAHGGDvqATDSHSIFSYEETAKLAVGRLSEYNHHFIKSFTYHSSVYFLFYRRDLKSQSREYKTYISRICLDDSHY 266
Cdd:cd11275    161 TRNLRAHGDD--ATDSHSIFSYEETAKLAVGRLSEYNHHFIKAFTYGSSVYFLFYRRDLKSQSREYKTYISRICLDDSHY 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  267 YSYVELPLLCQSKANTYSLLQAAYVTRPGKELAQGQLDTEGEVLFAAFSAWQASSGKLSEESALCVYTMEEVDRLTNWTR 346
Cdd:cd11275    239 YSYVELPLLCQSKANTYSLLQAAYVTQPGERLAQGQLDTDGEVLFAAFSAWQASSGKLSEESALCAYPMDEVDRLTNWTR 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  347 DVCYMRDGKSEEGTEVAYIEYDVSSNCVQLPADTLYAYPCGSDHTPSPMASRVPLEAAPLLEKTEARLTAVAVNVEDGHT 426
Cdd:cd11275    319 DVCYTRDGKAEDGTEVAYIEYDVSSNCVQLPADTLDAYPCGSDHTPSPMASRVPLEATPLLEWTEIRLTAVAVNVEDGHT 398

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1208037337  427 IAFLGDSRGRLHKVYLGAQGEAHTYASVSIQVNSMVSGDLLFDQLQEHLFVMTQSMVVKVPIM 489
Cdd:cd11275    399 IAFLGDSRGRLHKVYLGAGGDAHTYSSQSIQQNSAVSGDLLFDQLQEHLYVMTQSTVLKVPIA 461
Plexin_cytopl pfam08337
Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various ...
 1630-2166 0e+00

Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various plexins. Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels. The cytoplasmic region, which has been called a SEX domain in some members of this family, is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins. This domain acts as a RasGAP domain.


:

Pssm-ID: 462434 [Multi-domain]  Cd Length: 500  Bit Score: 893.86  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1630 GIPFLDYKSYAERIFFPGHRESPLQRDLDIP---ECRRQTVEQGLVQLSNLLNSKLFLTKFIHTLEIQRTFSPRDRAYVA 1706
Cdd:pfam08337    1 GIPFLDYRTYAMRVLFPGVEDHPLLVLLDVPvtnDGRRTNVEQALTQFSQLLNNKLFLLTFIRTLESQRSFSIRDRCNVA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1707 SLLTVSLHGKLEYFTDILKTLLNDLVEQYV-AKNPKLMLRRTETVVEKLLTNWMSICLYAFVRDSVGEPLYMLFRGIKHQ 1785
Cdd:pfam08337   81 SLLMVALHGKLEYATEILKTLLRDLIDKSVeSKNPKLLLRRTESVVEKMLTNWMSICLYPFLRECAGEPLFLLYKAIKQQ 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1786 VDKGPVDWVTGKAKYTLNDNRLLREDLEYRTLTLNALTQAGvgaggaEDSQGISAKVLDCDTITQVKEKILDQIYKGTPY 1865
Cdd:pfam08337  161 VEKGPVDAITGKARYTLSEDKLLREQIDYKTLTLHVIFEEG------ENSESVPVKVLDCDTITQVKEKILDAIYKNTPY 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1866 CHRPDPDTLDLEWRSGLAGHLILSDEDVTSVVQGTWKRLNTLQHYKVPDGATVALVPrltkhihrenqdyipgektpmle 1945
Cdd:pfam08337  235 SQRPSIDEVDLEWRHGRGGRLTLQDEDSTSKVEGGWKKLNTLAHYKVPDGATLALIP----------------------- 291

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1946 dadeggiKLWHLVKPTEEPELPKHrrgslrDRERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILST-NRPVPLAVKYFF 2024
Cdd:pfam08337  292 -------KYWHLVKPSDEGDQRKK------SERRKKAIPEIYLTRLLSTKGTLQKFVDDLFESILSVpNSALPLAVKYLF 358

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 2025 DLLDEQAIHYGIADPETIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNVDAVLLVIAQTFMDSCTIADHKLGRDSPINK 2104
Cdd:pfam08337  359 DFLDEQAEKHGITDPEVLHIWKSNSLPLRFWVNIIKNPQFVFDINKSPIVDSCLSVIAQTFMDSCSTSEHRLGKDSPSNK 438

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1208037337 2105 LLYARDIPRYKQMVERYYADIRQTISASDQEMNSALAELSRNYSGDLNSLVALHELYKYINK 2166
Cdd:pfam08337  439 LLYAKDIPRYKQMVERYYKDISNMPPISDQEMNAFLAEESRKHQNEFNTSAALKELYKYVNK 500
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1139-1230 5.98e-28

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238585  Cd Length: 94  Bit Score: 109.33  E-value: 5.98e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1139 PLIHSVYPLSGPVEGGTRITITGSNLGQKHQDIAETVTVAGIPCAVDAQEYEISSSIVCITGGSWTERFGHiVVEVPGGG 1218
Cdd:cd01180      1 PVITEFFPLSGPLEGGTRLTICGSNLGLRKNDVRHGVRVGGVPCNPEPPEYSSSEKIVCTTGPAGNPVFNG-PVEVTVGH 79

                           90
                   ....*....|....*
gi 1208037337 1219 ---RGVSGHVFTYQN 1230
Cdd:cd01180     80 gsfRTESSEGFSFVD 94
TIG_plexin pfam17960
TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and ...
 549-636 7.40e-27

TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and Transcription factors) found in plexins.


:

Pssm-ID: 465588  Cd Length: 89  Bit Score: 105.81  E-value: 7.40e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  549 TPANISREEKRNIFLAISDLPSLreEEFYSCYFEDY-ESPAVLTESGIMCPSPDPSQAPALPTGTDHVTIKLVVRF--HD 625
Cdd:pfam17960    1 TPDNISRTTATQLTLTVPNLPAL--SEGYSCVFGDLtESPATVHDNGVKCATPPPSQLPPIPTGQDHVTVKLSLRSseTG 78

                           90
                   ....*....|.
gi 1208037337  626 IFIASVDFSFY 636
Cdd:pfam17960   79 VDFASTNFTFY 89
TIG_2 super family cl39440
TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG ...
 992-1091 2.95e-23

TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG domains have an Ig-like fold.


The actual alignment was detected with superfamily member pfam18020:

Pssm-ID: 465619  Cd Length: 94  Bit Score: 95.81  E-value: 2.95e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  992 GSSLFPVNVARKITLLGKNFHLYQDQQWDYECVLNLEGRTVVMEAYVEGEETnkslcyITCQMNQYSYAAPQLEFSAMVF 1071
Cdd:pfam18020    1 GSILVPVGVEREITLKARNLPLFQSGQLGYECVFEIEGATHVVPASRESSDS------ITCQEHQFSYSGSSGELPATFY 74

                           90       100
                   ....*....|....*....|
gi 1208037337 1072 VQRRRHLRVDSAADLHVTFY 1091
Cdd:pfam18020   75 VTWNGGHRLDNPANLQVVLY 94
IPT super family cl15674
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1321-1443 2.12e-19

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


The actual alignment was detected with superfamily member cd01181:

Pssm-ID: 472823  Cd Length: 99  Bit Score: 85.16  E-value: 2.12e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1321 PNITFAEPPKSFLSGGRVLRVHGYNLDVVQKPKIRVTVspserrrrgvgrwrriipdsecpedslcsIQQFEEPCLINSS 1400
Cdd:cd01181      1 PTITRIEPEWSFLSGGTPITVTGTNLNTVQEPRIRVKY-----------------------------GGVEKTSCKVRNS 51

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1208037337 1401 YLILCKTPAINLLLRS---VRIKLEFILDNLSF-DFNSLHPMPFSYE 1443
Cdd:cd01181     52 TLMTCPAPSLALLNRSpepGERPVEFGLDGDNVqSLLILNRTSFSYY 98
IPT super family cl15674
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1231-1318 5.76e-17

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


The actual alignment was detected with superfamily member cd01179:

Pssm-ID: 472823  Cd Length: 85  Bit Score: 77.65  E-value: 5.76e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1231 PELKSIVPTQGPKAGGTCLTLLGSKLLTGhpNEISVLLGDLPCQILSEmTEDQLACQTSPSNVSTELPVTIKYGeQERRL 1310
Cdd:cd01179      1 PSITSLSPSYGPQSGGTRLTITGKHLNAG--SSVRVTVGGQPCKILSV-SSSQIVCLTPPSASPGEAPVKVLID-GARRL 76


                   ....*...
gi 1208037337 1311 EGSLFRYT 1318
Cdd:cd01179     77 APLVFTYT 84
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 491-540 4.90e-14

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


:

Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 68.12  E-value: 4.90e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1208037337  491 CSLYLDCESCLALKDPYCGWCVLQGRCSRRSECLRSRlSEQWLWSFNSTQ 540
Cdd:pfam01437    2 CSQYTSCSSCLAARDPYCGWCSSEGRCVRRSACGAPE-GNCEEWEQASSK 50
DUF5585 super family cl39316
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 686-1005 1.21e-12

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


The actual alignment was detected with superfamily member pfam17823:

Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 73.07  E-value: 1.21e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  686 AQIPTSivyPSSAAPLTKSSTTaPTTAPKPVTTPVHVGPSTVPHTEAiHVTPSAAPEPTTEPT--QSPGYTHLTLSTEAA 763
Cdd:pfam17823  112 SRALAA---AASSSPSSAAQSL-PAAIAALPSEAFSAPRAAACRANA-SAAPRAAIAAASAPHaaSPAPRTAASSTTAAS 186

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  764 SLQAATEAPLPPPADKPAVTVPET-TSPAASVLSSPSKNMDHIALPTEGPA--TAQDAWHTDPPTTLGGSPLHTSPVAAV 840
Cdd:pfam17823  187 STTAASSAPTTAASSAPATLTPARgISTAATATGHPAAGTALAAVGNSSPAagTVTAAVGTVTPAALATLAAAAGTVASA 266

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  841 -----TPSPQVTsfkwSPSPFPTTEALTSAIS-SPQMASQVPGSPV-VSDDAPGLPGTElpvsrLPTSAPPQWLLEKGTE 913
Cdd:pfam17823  267 agtinMGDPHAR----RLSPAKHMPSDTMARNpAAPMGAQAQGPIIqVSTDQPVHNTAG-----EPTPSPSNTTLEPNTP 337

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  914 lqdtedwmdllQAENDTSLFSASTLLSGDGDSSERDVPDFPRILHPDLdyqydapefweESEEPSWGPNACPCVEGIQGS 993
Cdd:pfam17823  338 -----------KSVASTNLAVVTTTKAQAKEPSASPVPVLHTSMIPEV-----------EATSPTTQPSPLLPTQGAAGP 395

                          330
                   ....*....|....
gi 1208037337  994 S--LFPVNVARKIT 1005
Cdd:pfam17823  396 GilLAPEQVATEAT 409
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 1092-1131 8.93e-05

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


:

Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 41.92  E-value: 8.93e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1208037337 1092 NCSvGHTDCSRCQTADSkYNCVWCGGDNpSCIFRGSCKEE 1131
Cdd:pfam01437    1 RCS-QYTSCSSCLAARD-PYCGWCSSEG-RCVRRSACGAP 37
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
650-679 4.65e-03

domain found in Plexins, Semaphorins and Integrins;


:

Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 37.14  E-value: 4.65e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1208037337   650 CQKCVSSLWG-CNWCIQQHLCTHKAACEEGV 679
Cdd:smart00423    8 CSECLLARDPyCAWCSSQGRCTSGERCDSRR 38
 
Name Accession Description Interval E-value
Sema_plexin_B1 cd11275
The Sema domain, a protein interacting module, of Plexin B1; Plexin B1 serves as the ...
 27-489 0e+00

The Sema domain, a protein interacting module, of Plexin B1; Plexin B1 serves as the Semaphorin 4D receptor and functions as a regulator of developing neurons and a tumor suppressor protein for melanoma. The Sema4D-plexin B signaling complex regulates dendritic and axonal complexity. The activation of Plexin B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. As a tumor suppressor, plexin B1 abrogates activation of the oncogenic receptor, c-Met, by its ligand, hepatocyte growth factor (HGF), in melanoma. Furthermore, plexin B1 suppresses integrin-dependent migration and activation of pp125FAK and inhibits Rho activity. Plexin B1 is highly expressed in endothelial cells and its activation by Sema4D elicits a potent proangiogenic response. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200536 [Multi-domain]  Cd Length: 461  Bit Score: 936.69  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337   27 FSHNATKFLHLSMDSESGTIYLGATNFLFQLTSDLLLENMVQTGPVLDSKDCLPPVSKLECPQAHHTDNHNKLLLVNTVQ 106
Cdd:cd11275      1 FSPNGTKFLHLSMDPESGTLYLGATNFLFQLTPDLLLENMVQTGPVLDSKDCLPPVSKLECPQAQHTNNHNKLLLVNPVQ 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  107 KELIVCGSVHQGICEKRSLASIDHVLFRPESPGDTQYVAANDPNITTVGLIAYSKDEVPLLFVGRGYTSRGVGGGIPPIT 186
Cdd:cd11275     81 KELIVCGSVHQGICEKRRLGSIDHVLFRPERPGDTQYVAANDPNVTTVGLVAYSKDGVPLLFVGRGYTSRGVGGGIPPIT 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  187 TRNLRAHGGDvqATDSHSIFSYEETAKLAVGRLSEYNHHFIKSFTYHSSVYFLFYRRDLKSQSREYKTYISRICLDDSHY 266
Cdd:cd11275    161 TRNLRAHGDD--ATDSHSIFSYEETAKLAVGRLSEYNHHFIKAFTYGSSVYFLFYRRDLKSQSREYKTYISRICLDDSHY 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  267 YSYVELPLLCQSKANTYSLLQAAYVTRPGKELAQGQLDTEGEVLFAAFSAWQASSGKLSEESALCVYTMEEVDRLTNWTR 346
Cdd:cd11275    239 YSYVELPLLCQSKANTYSLLQAAYVTQPGERLAQGQLDTDGEVLFAAFSAWQASSGKLSEESALCAYPMDEVDRLTNWTR 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  347 DVCYMRDGKSEEGTEVAYIEYDVSSNCVQLPADTLYAYPCGSDHTPSPMASRVPLEAAPLLEKTEARLTAVAVNVEDGHT 426
Cdd:cd11275    319 DVCYTRDGKAEDGTEVAYIEYDVSSNCVQLPADTLDAYPCGSDHTPSPMASRVPLEATPLLEWTEIRLTAVAVNVEDGHT 398

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1208037337  427 IAFLGDSRGRLHKVYLGAQGEAHTYASVSIQVNSMVSGDLLFDQLQEHLFVMTQSMVVKVPIM 489
Cdd:cd11275    399 IAFLGDSRGRLHKVYLGAGGDAHTYSSQSIQQNSAVSGDLLFDQLQEHLYVMTQSTVLKVPIA 461
Plexin_cytopl pfam08337
Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various ...
 1630-2166 0e+00

Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various plexins. Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels. The cytoplasmic region, which has been called a SEX domain in some members of this family, is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins. This domain acts as a RasGAP domain.


Pssm-ID: 462434 [Multi-domain]  Cd Length: 500  Bit Score: 893.86  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1630 GIPFLDYKSYAERIFFPGHRESPLQRDLDIP---ECRRQTVEQGLVQLSNLLNSKLFLTKFIHTLEIQRTFSPRDRAYVA 1706
Cdd:pfam08337    1 GIPFLDYRTYAMRVLFPGVEDHPLLVLLDVPvtnDGRRTNVEQALTQFSQLLNNKLFLLTFIRTLESQRSFSIRDRCNVA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1707 SLLTVSLHGKLEYFTDILKTLLNDLVEQYV-AKNPKLMLRRTETVVEKLLTNWMSICLYAFVRDSVGEPLYMLFRGIKHQ 1785
Cdd:pfam08337   81 SLLMVALHGKLEYATEILKTLLRDLIDKSVeSKNPKLLLRRTESVVEKMLTNWMSICLYPFLRECAGEPLFLLYKAIKQQ 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1786 VDKGPVDWVTGKAKYTLNDNRLLREDLEYRTLTLNALTQAGvgaggaEDSQGISAKVLDCDTITQVKEKILDQIYKGTPY 1865
Cdd:pfam08337  161 VEKGPVDAITGKARYTLSEDKLLREQIDYKTLTLHVIFEEG------ENSESVPVKVLDCDTITQVKEKILDAIYKNTPY 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1866 CHRPDPDTLDLEWRSGLAGHLILSDEDVTSVVQGTWKRLNTLQHYKVPDGATVALVPrltkhihrenqdyipgektpmle 1945
Cdd:pfam08337  235 SQRPSIDEVDLEWRHGRGGRLTLQDEDSTSKVEGGWKKLNTLAHYKVPDGATLALIP----------------------- 291

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1946 dadeggiKLWHLVKPTEEPELPKHrrgslrDRERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILST-NRPVPLAVKYFF 2024
Cdd:pfam08337  292 -------KYWHLVKPSDEGDQRKK------SERRKKAIPEIYLTRLLSTKGTLQKFVDDLFESILSVpNSALPLAVKYLF 358

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 2025 DLLDEQAIHYGIADPETIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNVDAVLLVIAQTFMDSCTIADHKLGRDSPINK 2104
Cdd:pfam08337  359 DFLDEQAEKHGITDPEVLHIWKSNSLPLRFWVNIIKNPQFVFDINKSPIVDSCLSVIAQTFMDSCSTSEHRLGKDSPSNK 438

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1208037337 2105 LLYARDIPRYKQMVERYYADIRQTISASDQEMNSALAELSRNYSGDLNSLVALHELYKYINK 2166
Cdd:pfam08337  439 LLYAKDIPRYKQMVERYYKDISNMPPISDQEMNAFLAEESRKHQNEFNTSAALKELYKYVNK 500
RasGAP_plexin_B1 cd12793
Ras-GTPase Activating Domain of plexin-B1; Plexins form a conserved family of transmembrane ...
 1630-2203 0e+00

Ras-GTPase Activating Domain of plexin-B1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B1 serves as the Semaphorin 4D receptor and functions as a regulator of developing neurons and a tumor suppressor protein for melanoma. The Sema4D and plexin-B1 signaling complex regulates dendritic and axonal complexity. The activation of Plexin-B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. As a tumor suppressor, plexin-B1 abrogates activation of the oncogenic receptor, c-Met, by its ligand, hepatocyte growth factor (HGF), in melanoma. Furthermore, plexin-B1 suppresses integrin-dependent migration and activation of pp125FAK and inhibits Rho activity. Plexin-B1 is highly expressed in endothelial cells and its activation by Sema4D elicits a potent proangiogenic response. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213353 [Multi-domain]  Cd Length: 394  Bit Score: 797.70  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1630 GIPFLDYKSYAERIFFPGHRESPLQRDLDIPECRRQTVEQGLVQLSNLLNSKLFLTKFIHTLEIQRTFSPRDRAYVASLL 1709
Cdd:cd12793      1 GIPFLDYRMYAERIFFPGHRESPLRRDLDVPECRRQTVEQGLVQLSNLLNSKLFLTKFIHTLESQRTFSPRDRAYVASLL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1710 TVSLHGKLEYFTDILKTLLNDLVEQYVAKNPKLMLRRTETVVEKLLTNWMSICLYAFVRDSVGEPLYMLFRGIKHQVDKG 1789
Cdd:cd12793     81 TVALHGKLEYFTDILKTLLNDLVEQYVAKNPKLMLRRTETVVEKLLTNWMSICLYTFLRDSAGESLYMLFRAIKHQVDKG 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1790 PVDWVTGKakytlndnrllredleyrtltlnaltqagvgaggaedsqgisakvldcdtitqvkekildqiykgtpychrp 1869
Cdd:cd12793    161 PVDAVTGK------------------------------------------------------------------------ 168

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1870 dpdtldlewrsglaghlilsdedvtsvvqgtwkrlntlqhykvpdgatvalvprltkhihrenqdyipgektpmledade 1949
Cdd:cd12793        --------------------------------------------------------------------------------

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1950 ggiklwhlvkpteepelpkhrrgslrdrERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTNRPVPLAVKYFFDLLDE 2029
Cdd:cd12793    169 ----------------------------ERAKAIPEIYLTRLLSMKGTLQKFVDDLFTVILSTSRPVPLAVKYFFDLLDE 220

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 2030 QAIHYGIADPETIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNVDAVLLVIAQTFMDSCTIADHKLGRDSPINKLLYAR 2109
Cdd:cd12793    221 QALQHGISDPETIHIWKTNSLPLRFWINIIKNPQFIFDVQTSDNVDAVLSVIAQTFMDSCTIADHKLGRDSPINKLLYAR 300

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 2110 DIPRYKQMVERYYADIRQTISASDQEMNSALAELSRNYSGDLNSLVALHELYKYINKYYDQIITALEEDPTAQKMQLGYR 2189
Cdd:cd12793    301 DIPRYKQMVERYYADIRQTVSASDQEMNSALAELSRNYSGELNYLVALHELYKYINKYYDQIITALEEDSTAQKMQLGYR 380

                          570
                   ....*....|....
gi 1208037337 2190 LQQIAAAVENKVTD 2203
Cdd:cd12793    381 LQQIAAAVENKVTD 394
Sema smart00630
semaphorin domain;
34-456 1.03e-68

semaphorin domain;


Pssm-ID: 214747 [Multi-domain]  Cd Length: 390  Bit Score: 237.65  E-value: 1.03e-68
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337    34 FLHLSMDSESGTIYLGATNFLFQLTSDLLLENMVQTGPVLDSKDCLPPVSKlecPQAHHTDNHNKL-LLVNTVQKELIVC 112
Cdd:smart00630    1 LQHLLLDEDNGTLYVGARNRLYQLSLNLILEAELKTGPVLSSPDCEECVSK---GKDPPTDCVNYIrLLLDYNEDRLLVC 77

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337   113 GS-VHQGICEKRSLasidhvlfrpespgdtqyvaandpnittvgliayskdevPLLFVGRGYTSRGVGGGIPP-ITTRNL 190
Cdd:smart00630   78 GTnAFQPVCRLRNL---------------------------------------GELYVGTVADFSGSDPAIPRsLSVRRL 118

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337   191 RAHGGDVQATDSHSIFSYeetaklavgrlseYNHHFIKSFTYHSSVYFLFYRR--DLKSQSREYKTYISRICLDD----- 263
Cdd:smart00630  119 KGTSGVSLRTVLYDSKWL-------------NEPNFVYAFESGDFVYFFFRETavEDDNCGKAVHSRVARVCKNDvggpr 185

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337   264 ---SHYYSYVELPLLCQSKANT---YSLLQAAYVTRPGKElaqgqldtEGEVLFAAFSAWQASSGKlseeSALCVYTMEE 337
Cdd:smart00630  186 sldKKWTSFLKARLECSVPGEDpfyFNELQAAFLLPPGSE--------SDDVLYGVFSTSSNPIPG----SAVCAFSLSD 253

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337   338 VDRLTNWTRDVCYMRDGKSEEGTEvAYIEYDVSSNCVQLPADTLyAYPC----GSDHTPSPMASRVPLEAAPLLEKT--E 411
Cdd:smart00630  254 INAVFNGPFKECETSTSQWLPYSR-GKVPYPRPGTCPNKPPSSK-DLPDetlnFIKSHPLMDEVVQPLTGRPLFVKTdsN 331

                           410       420       430       440       450
                    ....*....|....*....|....*....|....*....|....*....|.
gi 1208037337   412 ARLTAVAVNVED---GHTIAFLGDSRGRLHKVYL---GAQGEAHTYASVSI 456
Cdd:smart00630  332 YLLTSIAVDRVAtdgNYTVLFLGTSDGRILKVVLsesSSSSESVVLEEISV 382
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1139-1230 5.98e-28

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 109.33  E-value: 5.98e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1139 PLIHSVYPLSGPVEGGTRITITGSNLGQKHQDIAETVTVAGIPCAVDAQEYEISSSIVCITGGSWTERFGHiVVEVPGGG 1218
Cdd:cd01180      1 PVITEFFPLSGPLEGGTRLTICGSNLGLRKNDVRHGVRVGGVPCNPEPPEYSSSEKIVCTTGPAGNPVFNG-PVEVTVGH 79

                           90
                   ....*....|....*
gi 1208037337 1219 ---RGVSGHVFTYQN 1230
Cdd:cd01180     80 gsfRTESSEGFSFVD 94
TIG_plexin pfam17960
TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and ...
 549-636 7.40e-27

TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and Transcription factors) found in plexins.


Pssm-ID: 465588  Cd Length: 89  Bit Score: 105.81  E-value: 7.40e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  549 TPANISREEKRNIFLAISDLPSLreEEFYSCYFEDY-ESPAVLTESGIMCPSPDPSQAPALPTGTDHVTIKLVVRF--HD 625
Cdd:pfam17960    1 TPDNISRTTATQLTLTVPNLPAL--SEGYSCVFGDLtESPATVHDNGVKCATPPPSQLPPIPTGQDHVTVKLSLRSseTG 78

                           90
                   ....*....|.
gi 1208037337  626 IFIASVDFSFY 636
Cdd:pfam17960   79 VDFASTNFTFY 89
Sema pfam01403
Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and ...
 286-469 1.26e-25

Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and Swiss:P51805


Pssm-ID: 460197 [Multi-domain]  Cd Length: 180  Bit Score: 105.82  E-value: 1.26e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  286 LQAAYVTRPGKELAQGqldtegEVLFAAFSAWQASSgklSEESALCVYTMEEVDRLTNwTRDVCYMRDGkSEEGTEVAYI 365
Cdd:pfam01403    1 LQDVFVLKPGAGDALD------TVLYGVFTTQWSNS---IGGSAVCAFSLSDINAVFE-GPFKEQEKSD-SKWLPYTGKV 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  366 EYDVSSNCV------QLPADTLyaypCGSDHTPSPMASRVPLEAAPLLEKTEARLTAVAVN---VEDG-HTIAFLGDSRG 435
Cdd:pfam01403   70 PYPRPGTCIndplrlDLPDSVL----NFVKDHPLMDEAVQPVGGRPLLVRTGVRLTSIAVDrvqALDGnYTVLFLGTDDG 145

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 1208037337  436 RLHKVYLGAQGEAHTYASVSI-QVNSMVSGDLLFD 469
Cdd:pfam01403  146 RLHKVVLVGSEESHIIEEIQVfPEPQPVLNLLLSS 180
TIG_2 pfam18020
TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG ...
 992-1091 2.95e-23

TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG domains have an Ig-like fold.


Pssm-ID: 465619  Cd Length: 94  Bit Score: 95.81  E-value: 2.95e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  992 GSSLFPVNVARKITLLGKNFHLYQDQQWDYECVLNLEGRTVVMEAYVEGEETnkslcyITCQMNQYSYAAPQLEFSAMVF 1071
Cdd:pfam18020    1 GSILVPVGVEREITLKARNLPLFQSGQLGYECVFEIEGATHVVPASRESSDS------ITCQEHQFSYSGSSGELPATFY 74

                           90       100
                   ....*....|....*....|
gi 1208037337 1072 VQRRRHLRVDSAADLHVTFY 1091
Cdd:pfam18020   75 VTWNGGHRLDNPANLQVVLY 94
IPT_plexin_repeat3 cd01181
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1321-1443 2.12e-19

Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238586  Cd Length: 99  Bit Score: 85.16  E-value: 2.12e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1321 PNITFAEPPKSFLSGGRVLRVHGYNLDVVQKPKIRVTVspserrrrgvgrwrriipdsecpedslcsIQQFEEPCLINSS 1400
Cdd:cd01181      1 PTITRIEPEWSFLSGGTPITVTGTNLNTVQEPRIRVKY-----------------------------GGVEKTSCKVRNS 51

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1208037337 1401 YLILCKTPAINLLLRS---VRIKLEFILDNLSF-DFNSLHPMPFSYE 1443
Cdd:cd01181     52 TLMTCPAPSLALLNRSpepGERPVEFGLDGDNVqSLLILNRTSFSYY 98
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1231-1318 5.76e-17

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 77.65  E-value: 5.76e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1231 PELKSIVPTQGPKAGGTCLTLLGSKLLTGhpNEISVLLGDLPCQILSEmTEDQLACQTSPSNVSTELPVTIKYGeQERRL 1310
Cdd:cd01179      1 PSITSLSPSYGPQSGGTRLTITGKHLNAG--SSVRVTVGGQPCKILSV-SSSQIVCLTPPSASPGEAPVKVLID-GARRL 76


                   ....*...
gi 1208037337 1311 EGSLFRYT 1318
Cdd:cd01179     77 APLVFTYT 84
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1139-1228 4.89e-14

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 69.40  E-value: 4.89e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1139 PLIHSVYPLSGPVEGGTRITITGSNLGQKHQDIaeTVTVAGIPCAVDAQeyeISSSIVCITGGSWTERFGhIVVEVPGGG 1218
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDL--KVTIGGTPCTVISV---SSTTIVCTTPPGTSGLVN-VSVTVGGGG 74

                           90
                   ....*....|
gi 1208037337 1219 RGVSGHVFTY 1228
Cdd:pfam01833   75 ISSSPLTFTY 84
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 491-540 4.90e-14

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 68.12  E-value: 4.90e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1208037337  491 CSLYLDCESCLALKDPYCGWCVLQGRCSRRSECLRSRlSEQWLWSFNSTQ 540
Cdd:pfam01437    2 CSQYTSCSSCLAARDPYCGWCSSEGRCVRRSACGAPE-GNCEEWEQASSK 50
IPT smart00429
ig-like, plexins, transcription factors;
1139-1228 9.14e-13

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 65.90  E-value: 9.14e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  1139 PLIHSVYPLSGPVEGGTRITITGSNLGqKHQDIAETVTVAGIPCAVDAQEyeiSSSIVCITGGSWTERFGHIVVEVPGGG 1218
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLK-SISVVFVEVGVGEAPCTFSPSS---STAIVCKTPPYHNIPGSVPVRTVGLRN 77

                            90
                    ....*....|..
gi 1208037337  1219 RGVSG--HVFTY 1228
Cdd:smart00429   78 GGVPSspQPFTY 89
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 686-1005 1.21e-12

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 73.07  E-value: 1.21e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  686 AQIPTSivyPSSAAPLTKSSTTaPTTAPKPVTTPVHVGPSTVPHTEAiHVTPSAAPEPTTEPT--QSPGYTHLTLSTEAA 763
Cdd:pfam17823  112 SRALAA---AASSSPSSAAQSL-PAAIAALPSEAFSAPRAAACRANA-SAAPRAAIAAASAPHaaSPAPRTAASSTTAAS 186

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  764 SLQAATEAPLPPPADKPAVTVPET-TSPAASVLSSPSKNMDHIALPTEGPA--TAQDAWHTDPPTTLGGSPLHTSPVAAV 840
Cdd:pfam17823  187 STTAASSAPTTAASSAPATLTPARgISTAATATGHPAAGTALAAVGNSSPAagTVTAAVGTVTPAALATLAAAAGTVASA 266

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  841 -----TPSPQVTsfkwSPSPFPTTEALTSAIS-SPQMASQVPGSPV-VSDDAPGLPGTElpvsrLPTSAPPQWLLEKGTE 913
Cdd:pfam17823  267 agtinMGDPHAR----RLSPAKHMPSDTMARNpAAPMGAQAQGPIIqVSTDQPVHNTAG-----EPTPSPSNTTLEPNTP 337

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  914 lqdtedwmdllQAENDTSLFSASTLLSGDGDSSERDVPDFPRILHPDLdyqydapefweESEEPSWGPNACPCVEGIQGS 993
Cdd:pfam17823  338 -----------KSVASTNLAVVTTTKAQAKEPSASPVPVLHTSMIPEV-----------EATSPTTQPSPLLPTQGAAGP 395

                          330
                   ....*....|....
gi 1208037337  994 S--LFPVNVARKIT 1005
Cdd:pfam17823  396 GilLAPEQVATEAT 409
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
490-527 4.55e-12

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 62.56  E-value: 4.55e-12
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1208037337   490 ECSLYLDCESCLALKDPYCGWCVLQGRCSRRSECLRSR 527
Cdd:smart00423    1 RCSKYTSCSECLLARDPYCAWCSSQGRCTSGERCDSRR 38
PHA03247 PHA03247
large tegument protein UL36; Provisional
 687-905 1.47e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 70.35  E-value: 1.47e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  687 QIPTSIVYPSSAAPLTKSST-----TAPTTAPKPVTTPVHVGPSTVPHTEAIHVTPSA-APEPTTEPTQSPGYthltlST 760
Cdd:PHA03247  2681 QRPRRRAARPTVGSLTSLADpppppPTPEPAPHALVSATPLPPGPAAARQASPALPAApAPPAVPAGPATPGG-----PA 2755

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  761 EAASLQAATEAPLP-PPADKPAVTVPETTSPAASVLSSPSKNMDHIALPTEGPATAQDAWHTDPPTTLGGSPLHTSPVAA 839
Cdd:PHA03247  2756 RPARPPTTAGPPAPaPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQ 2835

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1208037337  840 VTPSPQvtsfkwSPSPFPTTEALTSAIsspqmasqVPGSPVV----SDDAPGLPGT--ELPVSRLPTSAPPQ 905
Cdd:PHA03247  2836 PTAPPP------PPGPPPPSLPLGGSV--------APGGDVRrrppSRSPAAKPAApaRPPVRRLARPAVSR 2893
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1231-1317 1.76e-08

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 53.60  E-value: 1.76e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1231 PELKSIVPTQGPKAGGTCLTLLGSKLLTGHPNeISVLLGDLPCQILSeMTEDQLACQTsPSNVSTELPVTIKYGEQERRL 1310
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSD-LKVTIGGTPCTVIS-VSSTTIVCTT-PPGTSGLVNVSVTVGGGGISS 77


                   ....*..
gi 1208037337 1311 EGSLFRY 1317
Cdd:pfam01833   78 SPLTFTY 84
IPT smart00429
ig-like, plexins, transcription factors;
1320-1442 6.99e-08

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 52.04  E-value: 6.99e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  1320 DPNITFAEPPKSFLSGGRVLRVHGYNLDVVQKPKIRVTVSPSErrrrgvgrwrriipdsecpedslCSIQQfeepcliNS 1399
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGEAP-----------------------CTFSP-------SS 50

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....
gi 1208037337  1400 SYLILCKTPAINLLLRSVRI-KLEFILDNLSFDfnslhPMPFSY 1442
Cdd:smart00429   51 STAIVCKTPPYHNIPGSVPVrTVGLRNGGVPSS-----PQPFTY 89
IPT smart00429
ig-like, plexins, transcription factors;
1230-1318 1.91e-07

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 50.88  E-value: 1.91e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  1230 NPELKSIVPTQGPKAGGTCLTLLGSKLLTGHPNEISVLLGDLPCQILSEmTEDQLACQTSPSNVST-ELPV-TIKYGEQE 1307
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGEAPCTFSPS-SSTAIVCKTPPYHNIPgSVPVrTVGLRNGG 79

                            90
                    ....*....|.
gi 1208037337  1308 RRLEGSLFRYT 1318
Cdd:smart00429   80 VPSSPQPFTYV 90
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
689-894 2.33e-06

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 52.83  E-value: 2.33e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  689 PTSIVYPSSAAPLTKSSTTAPTTAPKPVTTPVHVGPSTVPHTEAiHVTPSAAPEPTTEPTQSPGYTHLTLSTEAASLQAA 768
Cdd:COG3469     17 ATAVTLLGAAATAASVTLTAATATTVVSTTGSVVVAASGSAGSG-TGTTAASSTAATSSTTSTTATATAAAAAATSTSAT 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  769 TEAPLPP-PADKPAVTVPETTSPAASVLSSPSknmdhialPTEGPATAQDAWHTDPPTTLGGSPLHTSPVAAVTPSPQVT 847
Cdd:COG3469     96 LVATSTAsGANTGTSTVTTTSTGAGSVTSTTS--------STAGSTTTSGASATSSAGSTTTTTTVSGTETATGGTTTTS 167

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 1208037337  848 SFKWSPSPfPTTEALTSAISSPQMASQVPGSPVVSDDAPGLPGTELP 894
Cdd:COG3469    168 TTTTTTSA-STTPSATTTATATTASGATTPSATTTATTTGPPTPGLP 213
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 1092-1131 8.93e-05

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 41.92  E-value: 8.93e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1208037337 1092 NCSvGHTDCSRCQTADSkYNCVWCGGDNpSCIFRGSCKEE 1131
Cdd:pfam01437    1 RCS-QYTSCSSCLAARD-PYCGWCSSEG-RCVRRSACGAP 37
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
1092-1137 9.26e-05

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 41.76  E-value: 9.26e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 1208037337  1092 NCSVgHTDCSRCQTADSKYnCVWCGGDNpSCIFRGSCKEEVEDL----CP 1137
Cdd:smart00423    1 RCSK-YTSCSECLLARDPY-CAWCSSQG-RCTSGERCDSRRQNWlsggCP 47
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
650-679 4.65e-03

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 37.14  E-value: 4.65e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1208037337   650 CQKCVSSLWG-CNWCIQQHLCTHKAACEEGV 679
Cdd:smart00423    8 CSECLLARDPyCAWCSSQGRCTSGERCDSRR 38
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 650-675 8.19e-03

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 36.53  E-value: 8.19e-03
                           10        20
                   ....*....|....*....|....*..
gi 1208037337  650 CQKCVSSL-WGCNWCIQQHLCTHKAAC 675
Cdd:pfam01437    8 CSSCLAARdPYCGWCSSEGRCVRRSAC 34
 
Name Accession Description Interval E-value
Sema_plexin_B1 cd11275
The Sema domain, a protein interacting module, of Plexin B1; Plexin B1 serves as the ...
 27-489 0e+00

The Sema domain, a protein interacting module, of Plexin B1; Plexin B1 serves as the Semaphorin 4D receptor and functions as a regulator of developing neurons and a tumor suppressor protein for melanoma. The Sema4D-plexin B signaling complex regulates dendritic and axonal complexity. The activation of Plexin B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. As a tumor suppressor, plexin B1 abrogates activation of the oncogenic receptor, c-Met, by its ligand, hepatocyte growth factor (HGF), in melanoma. Furthermore, plexin B1 suppresses integrin-dependent migration and activation of pp125FAK and inhibits Rho activity. Plexin B1 is highly expressed in endothelial cells and its activation by Sema4D elicits a potent proangiogenic response. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200536 [Multi-domain]  Cd Length: 461  Bit Score: 936.69  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337   27 FSHNATKFLHLSMDSESGTIYLGATNFLFQLTSDLLLENMVQTGPVLDSKDCLPPVSKLECPQAHHTDNHNKLLLVNTVQ 106
Cdd:cd11275      1 FSPNGTKFLHLSMDPESGTLYLGATNFLFQLTPDLLLENMVQTGPVLDSKDCLPPVSKLECPQAQHTNNHNKLLLVNPVQ 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  107 KELIVCGSVHQGICEKRSLASIDHVLFRPESPGDTQYVAANDPNITTVGLIAYSKDEVPLLFVGRGYTSRGVGGGIPPIT 186
Cdd:cd11275     81 KELIVCGSVHQGICEKRRLGSIDHVLFRPERPGDTQYVAANDPNVTTVGLVAYSKDGVPLLFVGRGYTSRGVGGGIPPIT 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  187 TRNLRAHGGDvqATDSHSIFSYEETAKLAVGRLSEYNHHFIKSFTYHSSVYFLFYRRDLKSQSREYKTYISRICLDDSHY 266
Cdd:cd11275    161 TRNLRAHGDD--ATDSHSIFSYEETAKLAVGRLSEYNHHFIKAFTYGSSVYFLFYRRDLKSQSREYKTYISRICLDDSHY 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  267 YSYVELPLLCQSKANTYSLLQAAYVTRPGKELAQGQLDTEGEVLFAAFSAWQASSGKLSEESALCVYTMEEVDRLTNWTR 346
Cdd:cd11275    239 YSYVELPLLCQSKANTYSLLQAAYVTQPGERLAQGQLDTDGEVLFAAFSAWQASSGKLSEESALCAYPMDEVDRLTNWTR 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  347 DVCYMRDGKSEEGTEVAYIEYDVSSNCVQLPADTLYAYPCGSDHTPSPMASRVPLEAAPLLEKTEARLTAVAVNVEDGHT 426
Cdd:cd11275    319 DVCYTRDGKAEDGTEVAYIEYDVSSNCVQLPADTLDAYPCGSDHTPSPMASRVPLEATPLLEWTEIRLTAVAVNVEDGHT 398

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1208037337  427 IAFLGDSRGRLHKVYLGAQGEAHTYASVSIQVNSMVSGDLLFDQLQEHLFVMTQSMVVKVPIM 489
Cdd:cd11275    399 IAFLGDSRGRLHKVYLGAGGDAHTYSSQSIQQNSAVSGDLLFDQLQEHLYVMTQSTVLKVPIA 461
Plexin_cytopl pfam08337
Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various ...
 1630-2166 0e+00

Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various plexins. Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels. The cytoplasmic region, which has been called a SEX domain in some members of this family, is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins. This domain acts as a RasGAP domain.


Pssm-ID: 462434 [Multi-domain]  Cd Length: 500  Bit Score: 893.86  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1630 GIPFLDYKSYAERIFFPGHRESPLQRDLDIP---ECRRQTVEQGLVQLSNLLNSKLFLTKFIHTLEIQRTFSPRDRAYVA 1706
Cdd:pfam08337    1 GIPFLDYRTYAMRVLFPGVEDHPLLVLLDVPvtnDGRRTNVEQALTQFSQLLNNKLFLLTFIRTLESQRSFSIRDRCNVA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1707 SLLTVSLHGKLEYFTDILKTLLNDLVEQYV-AKNPKLMLRRTETVVEKLLTNWMSICLYAFVRDSVGEPLYMLFRGIKHQ 1785
Cdd:pfam08337   81 SLLMVALHGKLEYATEILKTLLRDLIDKSVeSKNPKLLLRRTESVVEKMLTNWMSICLYPFLRECAGEPLFLLYKAIKQQ 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1786 VDKGPVDWVTGKAKYTLNDNRLLREDLEYRTLTLNALTQAGvgaggaEDSQGISAKVLDCDTITQVKEKILDQIYKGTPY 1865
Cdd:pfam08337  161 VEKGPVDAITGKARYTLSEDKLLREQIDYKTLTLHVIFEEG------ENSESVPVKVLDCDTITQVKEKILDAIYKNTPY 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1866 CHRPDPDTLDLEWRSGLAGHLILSDEDVTSVVQGTWKRLNTLQHYKVPDGATVALVPrltkhihrenqdyipgektpmle 1945
Cdd:pfam08337  235 SQRPSIDEVDLEWRHGRGGRLTLQDEDSTSKVEGGWKKLNTLAHYKVPDGATLALIP----------------------- 291

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1946 dadeggiKLWHLVKPTEEPELPKHrrgslrDRERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILST-NRPVPLAVKYFF 2024
Cdd:pfam08337  292 -------KYWHLVKPSDEGDQRKK------SERRKKAIPEIYLTRLLSTKGTLQKFVDDLFESILSVpNSALPLAVKYLF 358

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 2025 DLLDEQAIHYGIADPETIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNVDAVLLVIAQTFMDSCTIADHKLGRDSPINK 2104
Cdd:pfam08337  359 DFLDEQAEKHGITDPEVLHIWKSNSLPLRFWVNIIKNPQFVFDINKSPIVDSCLSVIAQTFMDSCSTSEHRLGKDSPSNK 438

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1208037337 2105 LLYARDIPRYKQMVERYYADIRQTISASDQEMNSALAELSRNYSGDLNSLVALHELYKYINK 2166
Cdd:pfam08337  439 LLYAKDIPRYKQMVERYYKDISNMPPISDQEMNAFLAEESRKHQNEFNTSAALKELYKYVNK 500
RasGAP_plexin_B1 cd12793
Ras-GTPase Activating Domain of plexin-B1; Plexins form a conserved family of transmembrane ...
 1630-2203 0e+00

Ras-GTPase Activating Domain of plexin-B1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B1 serves as the Semaphorin 4D receptor and functions as a regulator of developing neurons and a tumor suppressor protein for melanoma. The Sema4D and plexin-B1 signaling complex regulates dendritic and axonal complexity. The activation of Plexin-B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. As a tumor suppressor, plexin-B1 abrogates activation of the oncogenic receptor, c-Met, by its ligand, hepatocyte growth factor (HGF), in melanoma. Furthermore, plexin-B1 suppresses integrin-dependent migration and activation of pp125FAK and inhibits Rho activity. Plexin-B1 is highly expressed in endothelial cells and its activation by Sema4D elicits a potent proangiogenic response. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213353 [Multi-domain]  Cd Length: 394  Bit Score: 797.70  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1630 GIPFLDYKSYAERIFFPGHRESPLQRDLDIPECRRQTVEQGLVQLSNLLNSKLFLTKFIHTLEIQRTFSPRDRAYVASLL 1709
Cdd:cd12793      1 GIPFLDYRMYAERIFFPGHRESPLRRDLDVPECRRQTVEQGLVQLSNLLNSKLFLTKFIHTLESQRTFSPRDRAYVASLL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1710 TVSLHGKLEYFTDILKTLLNDLVEQYVAKNPKLMLRRTETVVEKLLTNWMSICLYAFVRDSVGEPLYMLFRGIKHQVDKG 1789
Cdd:cd12793     81 TVALHGKLEYFTDILKTLLNDLVEQYVAKNPKLMLRRTETVVEKLLTNWMSICLYTFLRDSAGESLYMLFRAIKHQVDKG 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1790 PVDWVTGKakytlndnrllredleyrtltlnaltqagvgaggaedsqgisakvldcdtitqvkekildqiykgtpychrp 1869
Cdd:cd12793    161 PVDAVTGK------------------------------------------------------------------------ 168

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1870 dpdtldlewrsglaghlilsdedvtsvvqgtwkrlntlqhykvpdgatvalvprltkhihrenqdyipgektpmledade 1949
Cdd:cd12793        --------------------------------------------------------------------------------

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1950 ggiklwhlvkpteepelpkhrrgslrdrERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTNRPVPLAVKYFFDLLDE 2029
Cdd:cd12793    169 ----------------------------ERAKAIPEIYLTRLLSMKGTLQKFVDDLFTVILSTSRPVPLAVKYFFDLLDE 220

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 2030 QAIHYGIADPETIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNVDAVLLVIAQTFMDSCTIADHKLGRDSPINKLLYAR 2109
Cdd:cd12793    221 QALQHGISDPETIHIWKTNSLPLRFWINIIKNPQFIFDVQTSDNVDAVLSVIAQTFMDSCTIADHKLGRDSPINKLLYAR 300

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 2110 DIPRYKQMVERYYADIRQTISASDQEMNSALAELSRNYSGDLNSLVALHELYKYINKYYDQIITALEEDPTAQKMQLGYR 2189
Cdd:cd12793    301 DIPRYKQMVERYYADIRQTVSASDQEMNSALAELSRNYSGELNYLVALHELYKYINKYYDQIITALEEDSTAQKMQLGYR 380

                          570
                   ....*....|....
gi 1208037337 2190 LQQIAAAVENKVTD 2203
Cdd:cd12793    381 LQQIAAAVENKVTD 394
RasGAP_plexin_B cd12787
Ras-GTPase Activating Domain of type B plexins; Plexins form a conserved family of ...
 1630-2199 0e+00

Ras-GTPase Activating Domain of type B plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity.There are three members of the Plexin-B subfamily, namely B1, B2 and B3. Plexins-B1, B2 and B3 are receptors for Sema4D, Sema4C and Sema4G, and Sema5A, respectively. The activation of plexin-B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. By signaling the effect of Sema4C and Sema4G, the plexin-B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Plexin-B3, the receptor of Sema5A, is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin-B3 has been linked to verbal performance and white matter volume in human brain. Small GTPases play important roles in plexin-B signaling. Plexin-B1 activates Rho through Rho-specific guanine nucleotide exchange factors, leading to neurite retraction. Plexin-B1 possesses an intrinsic GTPase-activating protein activity for R-Ras and induces growth cone collapse through R-Ras inactivation. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213347 [Multi-domain]  Cd Length: 391  Bit Score: 720.17  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1630 GIPFLDYKSYAERIFFPGHRESPLQRD--LDIPECRRQTVEQGLVQLSNLLNSKLFLTKFIHTLEIQRTFSPRDRAYVAS 1707
Cdd:cd12787      1 GIPFLDYKTYAERVFFPGHKDGPLDVMikLDIPEPRRPTVEQGLYQLSNLLNSKLFLINFIHTLENQREFSARDRVYVAS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1708 LLTVSLHGKLEYFTDILKTLLNDLVEQYVAKNPKLMLRRTETVVEKLLTNWMSICLYAFVRDSVGEPLYMLFRGIKHQVD 1787
Cdd:cd12787     81 LLTVALHGKLEYYTDIMRTLLLDLLAQYVVKNPKLMLRRTETVVEKLLTNWMSICLYQFLRDSAGEPLYMLFRAIKHQVD 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1788 KGPVDWVTGKakytlndnrllredleyrtltlnaltqagvgaggaedsqgisakvldcdtitqvkekildqiykgtpych 1867
Cdd:cd12787    161 KGPVDAVTGK---------------------------------------------------------------------- 170

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1868 rpdpdtldlewrsglaghlilsdedvtsvvqgtwkrlntlqhykvpdgatvalvprltkhihrenqdyipgektpmleda 1947
Cdd:cd12787        --------------------------------------------------------------------------------

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1948 deggiklwhlvkpteepelpkhrrgslrdreRAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTNRPVPLAVKYFFDLL 2027
Cdd:cd12787    171 -------------------------------RAKAIPEIYLTRLLSMKGTLQKFVDDFFQSILSPGRPVPPAVKYFFDLL 219

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 2028 DEQAIHYGIADPETIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNVDAVLLVIAQTFMDSCTIADHKLGRDSPINKLLY 2107
Cdd:cd12787    220 DEQAEKHGIQDEDTIHIWKTNSLPLRFWVNILKNPQFIFDVHVSDNVDASLSVIAQTFMDACTRTEHKLGRDSPSNKLLY 299

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 2108 ARDIPRYKQMVERYYADIRQTISASDQEMNSALAELSRNYSGDLNSLVALHELYKYINKYYDQIITALEEDPTAQKMQLG 2187
Cdd:cd12787    300 AREIPRYKKMVERYYADIRQMVPASDQEMNSHLAELSRNYTDSLNTLVALHELYQYIQKYYDQIINALEEDPAAQKMQLA 379

                          570
                   ....*....|..
gi 1208037337 2188 YRLQQIAAAVEN 2199
Cdd:cd12787    380 FRLQQIAAAVEN 391
RasGAP_plexin_B3 cd12791
Ras-GTPase Activating Domain of plexin-B3; Plexins form a conserved family of transmembrane ...
 1630-2203 0e+00

Ras-GTPase Activating Domain of plexin-B3; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B3 is the receptor of semaphorin 5A. It is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin-B3 has been linked to verbal performance and white matter volume in human brain. Furthermore, Sema5A and plexin-B3 have been implicated in the progression of various types of cancer. They play an important role in the invasion and metastasis of gastric carcinoma. The protein and mRNA expression of Sema5A and its receptor plexin-B3 increased gradually in non-neoplastic mucosa, primary gastric carcinoma, and lymph node metastasis, and their expression is correlated. The stimulation of plexin-B3 by Sema5A binding in human glioma cells results in the inhibition of cell migration and invasion. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213351 [Multi-domain]  Cd Length: 397  Bit Score: 688.50  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1630 GIPFLDYKSYAERIFFPGHRESPLQR--DLDIPECRRQTVEQGLVQLSNLLNSKLFLTKFIHTLEIQRTFSPRDRAYVAS 1707
Cdd:cd12791      1 GIPFLDYRTYAERVFFPGHGGCPLQPslEGDGEEGRRATVEQGLTQLSNLLNSKLFLLTLIHTLEEQPSFSQRDRCHVAS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1708 LLTVSLHGKLEYFTDILKTLLNDLVEQYVAKNPKLMLRRTETVVEKLLTNWMSICLYAFVRDSVGEPLYMLFRGIKHQVD 1787
Cdd:cd12791     81 LLSLALHGKLEYLTDIMKTLLGDLAAHYVHKNPKLMLRRTETMVEKLLTNWMSICLYAFLREVAGEPLYMLFRAIKYQVD 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1788 KGPVDWVTGKakytlndnrllredleyrtltlnaltqagvgaggaedsqgisakvldcdtitqvkekildqiykgtpych 1867
Cdd:cd12791    161 KGPVDAVTGK---------------------------------------------------------------------- 170

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1868 rpdpdtldlewrsglaghlilsdedvtsvvqgtwkrlntlqhykvpdgatvalvprltkhihrenqdyipgektpmleda 1947
Cdd:cd12791        --------------------------------------------------------------------------------

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1948 deggiklwhlvkpteepelpkhrrgslrdRERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTNRPVPLAVKYFFDLL 2027
Cdd:cd12791    171 -----------------------------RERAKAIPEIYLTRLLSMKGTLQKFVDDTFQAILSVNRPVPIAVKYLFDFL 221

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 2028 DEQAIHYGIADPETIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNVDAVLLVIAQTFMDSCTIADHKLGRDSPINKLLY 2107
Cdd:cd12791    222 DELAEKHGIEDPETLHIWKTNSLLLRFWVNTLKNPQFIFDVRVSDNVDAILAVIAQTFIDSCTISEHKVGRDSPVNKLLY 301

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 2108 ARDIPRYKQMVERYYADIRQTISASDQEMNSALAELSRNYSGDLNSLVALHELYKYINKYYDQIITALEEDPTAQKMQLG 2187
Cdd:cd12791    302 AREIPRYKQMVEKYYADIRQSSPASYQEMNSALTELSGNYTSAPHCLVALQELYNHIHRYYDQIISALEEDPVGQKMQLA 381

                          570
                   ....*....|....*.
gi 1208037337 2188 YRLQQIAAAVENKVTD 2203
Cdd:cd12791    382 CRLQQIAALVENKVTD 397
Sema_plexin_B cd11245
The Sema domain, a protein interacting module, of Plexin B; Plexins, which contain semaphorin ...
 34-488 0e+00

The Sema domain, a protein interacting module, of Plexin B; Plexins, which contain semaphorin domains, function as receptors of semaphorins and may be the ancestors of semaphorins. There are three members of the Plexin B subfamily, namely B1, B2 and B3. Plexins B1, B2 and B3 are receptors for Sema4D, Sema4C and Sema4G, and Sema5A, respectively. The activation of plexin B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. By signaling the effect of Sema4C and Sema4G, the plexin B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Plexin B3, the receptor of Sema5A, is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin B3 has been linked to verbal performance and white matter volume in human brain. Small GTPases play important roles in plexin B signaling. Plexin B1 activates Rho through Rho-specific guanine nucleotide exchange factors, leading to neurite retraction. Plexin B1 possesses an intrinsic GTPase-activating protein activity for R-Ras and induces growth cone collapse through R-Ras inactivation. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200506 [Multi-domain]  Cd Length: 440  Bit Score: 583.43  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337   34 FLHLSMDSESGTIYLGATNFLFQLTSDLLLENMVQTGPVLDSKDCLPPVSKLECPQAHHTDNHNKLLLVNTVQKELIVCG 113
Cdd:cd11245      2 INHLAQDPQTGRLYLGAVNGLFQLSPNLQLESRADTGPKKDSPQCLPPITAAECPQAKETDNFNKLLLVNSANGTLVVCG 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  114 SVHQGICEKRSLASIDHVLFRPESPGDTQYVAANDPNITTVGLIAYSKDEVPLLFVGRGYTSRGvGGGIPPITTRNLRAH 193
Cdd:cd11245     82 SLFQGVCELRNLNSVNKPLYRPETPGDKQYVAANEPSVSTVGLISYFKDGLSLLFVGRGYTSSL-SGGIPPITTRLLQEH 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  194 ggdvqatDSHSIFSYEETAKLAVGRLSEYNHHFIKSFTYHSSVYFLFYRRDLKSQsREYKTYISRICLDDSHYYSYVELP 273
Cdd:cd11245    161 -------GEMDAFSNEVEAKLVVGSASRYHHDFVYAFADNGYIYFLFSRRPGTAD-STKRTYISRLCENDHHYYSYVELP 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  274 LLCQ-SKANTYSLLQAAYVTRPGKELaqgqldtEGEVLFAAFSAWQASSGKLSEESALCVYTMEEVDRLTNWTRDVCYMR 352
Cdd:cd11245    233 LNCTvNQENTYNLVQAAYLAKPGKVL-------NGKVLFGVFSADEASTAAPDGRSALCMYPLSSVDARFERTRESCYTG 305

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  353 DGKSEEGTEVAYIEYDVSSNCVQLPADTLYAYPCGSDHTPSPMASRVPLEAAPLLEkTEARLTAVAVNVEDGHTIAFLGD 432
Cdd:cd11245    306 EGLEDDKPETAYIEYNVKSICKTLPDKNVKAYPCGAEHTPSPLASRYPLAAKPILT-RNDMLTAVAVAVENGHTIAFLGD 384

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1208037337  433 SRGRLHKVYLGAqGEAHTYASVSIQVNSMVSGDLLFDQLQEHLFVMTQSMVVKVPI 488
Cdd:cd11245    385 SGGQLHKVYLDP-NHTDFYSTIPGDQDSAVNKDLLFDSTLNHLYVMTGKKISKVPV 439
RasGAP_plexin_B2 cd12792
Ras-GTPase Activating Domain of plexin-B2; Plexins form a conserved family of transmembrane ...
 1630-2203 0e+00

Ras-GTPase Activating Domain of plexin-B2; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B2 serves as the receptor of Sema4C and Sema4G. By signaling the effect of Sema4C and Sema4G, the plexin-B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Mice lacking Plexin-B2 demonstrated defects in closure of the neural tube and disorganization of the embryonic brain. In developing kidney, Sema4C and Plexin-B2 signaling modulates ureteric branching. Plexin-B2 is expressed both in the pretubular aggregates and the ureteric epithelium in the developing kidney. Deletion of Plexin-B2 results in renal hypoplasia and occasional double ureters. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213352 [Multi-domain]  Cd Length: 400  Bit Score: 559.63  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1630 GIPFLDYKSYAERIFF----PGHRESPLQRDLDIPECRRQTVEQGLVQLSNLLNSKLFLTKFIHTLEIQRTFSPRDRAYV 1705
Cdd:cd12792      1 RIPFLDYKTYTDRVFFlpskDGANDVMITGKLDIPEARRATVEQALNQFSNLLNSKTFLINFIHTLENQRDFNARAKVYF 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1706 ASLLTVSLHGKLEYFTDILKTLLNDLVEQYV-AKNPKLMLRRTETVVEKLLTNWMSICLYAFVRDSVGEPLYMLFRGIKH 1784
Cdd:cd12792     81 ASLLTVALHGKLEYYTDIMRTLLLELMEQYVhSKNPKLMLRRSETVVERMLSNWMSICLYQYLKDTAGEPLYKLFKAIKH 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1785 QVDKGPVDwvtgkakytlndnrllredleyrtltlnaltqagvgaggaedsqgisakvldcdtiTQVKEKildqiykgtp 1864
Cdd:cd12792    161 QVEKGPVD--------------------------------------------------------AVQKKK---------- 174

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1865 ychrpdpdtldlewrsglaghlilsdedvtsvvqgtwkrlntlqhykvpdgatvalvprltkhihrenqdyipgektpml 1944
Cdd:cd12792        --------------------------------------------------------------------------------

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1945 edadeggiklwhlvkpteepelpkhrrgslrdrERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTNRPVPLAVKYFF 2024
Cdd:cd12792    175 ---------------------------------ERTKAITEIYLTRLLSVKGTLQQFVDNFFRSVLCSGAVVPPAVKYFF 221

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 2025 DLLDEQAIHYGIADPETIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNVDAVLLVIAQTFMDSCTIADHKLGRDSPINK 2104
Cdd:cd12792    222 DFLDEQAEKHDIVDEETIHIWKTNSLPLRFWVNILKNPHFIFDVHVTEVVDASLSVIAQTFMDACTKTEHKLSRDSPSNK 301

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 2105 LLYARDIPRYKQMVERYYADIRQTISASDQEMNSALAELSRNYSGDLNSLVALHELYKYINKYYDQIITALEEDPTAQKM 2184
Cdd:cd12792    302 LLYAKEISTYKKMVDDYYKGIRQMVPVSDQDMNTHLAEISRAHTDKLNTQVALHQLYQYASKYYDEIINSLEEDPAAQSK 381

                          570
                   ....*....|....*....
gi 1208037337 2185 QLGYRLQQIAAAVENKVTD 2203
Cdd:cd12792    382 QLTLRLQQIAAALENKVTD 400
RasGAP_plexin cd12205
Ras-GTPase Activating Domain of plexins; Plexins form a conserved family of transmembrane ...
 1630-2195 0e+00

Ras-GTPase Activating Domain of plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Ligand binding activates signal transduction pathways controlling axon guidance in the nervous system and other developmental processes, including cell migration and morphogenesis, immune function, and tumor progression. Plexins are divided into four types (A-D) according to sequence similarity. In vertebrates, type A Plexins serve as the co-receptors for neuropilins to mediate the signaling of class 3 semaphorins except Sema3E, which signals through Plexin D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B. Plexin C1 serves as the receptor of Sema7A and plays regulation roles in both immune and nervous systems. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Other proteins having a RasGAP domain include p120GAP, IQGAP, Rab5-activating protein 6, and Neurofibromin. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213344 [Multi-domain]  Cd Length: 382  Bit Score: 558.38  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1630 GIPFLDYKSYAERIFFPGHRESPLQRDLDIPECRRQTVEQGLVQLSNLLNSKLFLTKFIHTLEIQRTFSPRDRAYVASLL 1709
Cdd:cd12205      1 GIPFLDFREYIIRVLFPGVNDHPVLLSKFVHGSRRPDLEDALSQFEQLLCNKQFLLTFIRTLESQPKFSSRDKCNVASLL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1710 TVSLHGKLEYFTDILKTLLNDLVEQYVAK-NPKLMLRRTETVVEKLLTNWMSICLYAFVRDSVGEPLYMLFRGIKHQVDK 1788
Cdd:cd12205     81 MVALQGKMEYATEILFDLLTDLIEKSVSKkHPKLMLRRTESVVEKLLTNWLSLCLYDYLKETAGEPLFLLYKALKQQIEK 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1789 GPVDWVtgkakytlndnrllredleyrtltlnaltqagvgaggaedsqgisakvldcdtitqvkekildqiykgtpychr 1868
Cdd:cd12205    161 GPVDAI-------------------------------------------------------------------------- 166

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1869 pdpdtldlewrsglaghlilsdedvtsvvqgtwkrlntlqhykvpdgatvalvprltkhihrenqdyipgektpmledad 1948
Cdd:cd12205        --------------------------------------------------------------------------------

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1949 eggiklwhlvkpteepelpkhrrgslrdreraKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTN-RPVPLAVKYFFDLL 2027
Cdd:cd12205    167 --------------------------------KLIPEIFLTRLLSTKGTLQKFVDDLFESILSVPqRSLPPAIKYLFDFL 214

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 2028 DEQAIHYGIADPETIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNVDAVLLVIAQTFMDSCTIADHKLGRDSPINKLLY 2107
Cdd:cd12205    215 DEQARKHGISDPDVLHAWKTNSLPLRFWVNIIKNPDFVFDVNKTPTVDSCLSVIAQTFMDACSTSEHKLGKDSPSNKLLF 294

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 2108 ARDIPRYKQMVERYYADIRQTISASDQEMNSALAELSRNYSGDLNSLVALHELYKYINKYYDQIITALEEDPTAQKMQLG 2187
Cdd:cd12205    295 AKDIPRYREMVANFYRDISNLPPVSDEEMNSYLAELSESHSGEFNTNVALSELYIYAVKYGDQLLEALEDDREARVQQLA 374


                   ....*...
gi 1208037337 2188 YRLQQIAA 2195
Cdd:cd12205    375 DKLSQVAR 382
Sema_plexin_B3 cd11277
The Sema domain, a protein interacting module, of Plexin B3; Plexin B3 is the receptor of ...
 27-488 7.43e-167

The Sema domain, a protein interacting module, of Plexin B3; Plexin B3 is the receptor of semaphorin 5A. It is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin B3 has been linked to verbal performance and white matter volume in human brain. Furthermore, Sema5A and plexin B3 have been implicated in the progression of various types of cancer. They play an important role in the invasion and metastasis of gastric carcinoma. The stimulation of plexin B3 by Sema5A binding in human glioma cells results in the inhibition of cell migration and invasion. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200538 [Multi-domain]  Cd Length: 434  Bit Score: 519.37  E-value: 7.43e-167
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337   27 FSHNATKFLHLSMDSESGTIYLGATNFLFQLTSDLLLENMVQTGPVLDSKDCLPPVSKLECPQAHHTDNHNKLLLVNTVQ 106
Cdd:cd11277      1 FSAPNATFNHLALDPGSGTLYVGAVNRLYQLSPDLQLLGEAVTGPVLDSPDCLPFRDPADCPQARLTDNANKLLLVSERA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  107 KELIVCGSVHQGICEKRSLASIDHVLFRPESPGDTQYVAANDPNITTVGLIAYSKDeVPLLFVGRGYTSRGvGGGIPPIT 186
Cdd:cd11277     81 GELVACGQVRQGVCEKRRLGNVAQVLYQAEDPGDGQFVAANDPGVATVGLVVEAPG-RDLLLVGRGLTGKL-SAGIPPLT 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  187 TRNLRAhggdVQAtdshsiFSYEETAKLAVGRLSEYNHHFIKSFTYHSSVYFLFYRRDLKSQsREYKTYISRICLDDSHY 266
Cdd:cd11277    159 IRQLAG----AQA------FSSEGLGKLVVGDFSDYNNSYVGAFAHNGYVYFLFRRRGARAQ-AEYRTYVARVCLGDTNL 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  267 YSYVELPLLCQskaNTYSLLQAAYVTRPGKElaqgqldtegevLFAAFSAWQASSGKLSEESALCVYTMEEVDRLTNWTR 346
Cdd:cd11277    228 YSYVEVPLVCQ---GGYNLAQAAYLAPGQGT------------LFVVFAAGQGSTPTPTDQTALCAYPLVELDSAMERAR 292

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  347 DVCYMRDGKSEEGTEVAYIEYDVSSNCVQLPADTLYAYPCGSDHTPSPMASRVPLEAAPLLeKTEARLTAVAVNVEDGHT 426
Cdd:cd11277    293 RLCYTAGGGGPNGKEEATIEYGVTSRCVNLPKDSPESYPCGDEHTPSPIASRQPLEAEPLL-TLTPPLTAVAALQEDGHT 371

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1208037337  427 IAFLGDSRGRLHKVYLGAQGeAHTYASVSI-QVNSMVSGDLLFDQLQEHLFVMTQSMVVKVPI 488
Cdd:cd11277    372 IAFLGDTQGQLHKVFLNGSA-GQVYSSQPVgPPGSAVNPDLLLDATGSHLYVLTARQVTKVPV 433
RasGAP_plexin_A cd12790
Ras-GTPase Activating Domain of type A plexins; Plexins form a conserved family of ...
 1630-2193 1.89e-161

Ras-GTPase Activating Domain of type A plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. They are divided into four types (A-D) according to sequence similarity. In vertebrates, there are four type A plexins (A1-A4) that serve as the co-receptors for neuropilins to mediate the signaling of class 3 semaphorins except Sema3E, which signals through Plexin-D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 1 and class 6 semaphorins signal through type A plexins, which mediate diverse biological functions including axon guidance, cardiovascular development, and immune function. Guanylyl cyclase Gyc76C and Off-track kinase (OTK), a putative receptor tyrosine kinase, modulate Sema1a and Plexin-A mediated axon repulsion. In their complex with Sema6s, type A plexins serve as signal-transducing subunits. An increasing number of molecules that interact with the intracellular region of Plexin-A have been identified; among them are IgCAMs (in axon guidance events) and Trem2-DAP12 (in immune responses). Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213350 [Multi-domain]  Cd Length: 385  Bit Score: 501.95  E-value: 1.89e-161
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1630 GIPFLDYKSYAERIFFPGHRESPLQRDLDIPECRRQTVEQGLVQLSNLLNSKLFLTKFIHTLEIQRTFSPRDRAYVASLL 1709
Cdd:cd12790      1 GIPFLDYRTYAMRVLFPGIEDHPVLRELEVERDRQENVEKGLRLFGQLLMNKTFLLTFIRTLESQRSFSMRDRGNVASLI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1710 TVSLHGKLEYFTDILKTLLNDLVEQYVAK--NPKLMLRRTETVVEKLLTNWMSICLYAFVRDSVGEPLYMLFRGIKHQVD 1787
Cdd:cd12790     81 MVVLQSKMEYATDILKQLLADLIEKNLESknHPKLLLRRTESVAEKMLTNWFTFLLYKFLKECAGEPLFMLFCAIKQQME 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1788 KGPVDWVtgkakytlndnrllredleyrtltlnaltqagvgaggaedsqgisakvldcdtitqvkekildqiykgtpych 1867
Cdd:cd12790    161 KGPIDAI------------------------------------------------------------------------- 167

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1868 rpdpdtldlewrsglaghlilsdedvtsvvqgtwkrlntlqhykvpdgatvalvprltkhihrenqdyipgektpmleda 1947
Cdd:cd12790        --------------------------------------------------------------------------------

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1948 deggiklwhlvkpteepelpkhrrgslrdreraKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTNR---PVPLAVKYFF 2024
Cdd:cd12790    168 ---------------------------------KMVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHrgsALPLAIKYMF 214

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 2025 DLLDEQAIHYGIADPETIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNVDAVLLVIAQTFMDSCTIADHKLGRDSPINK 2104
Cdd:cd12790    215 DFLDEQADQHGITDPEVVHTWKSNCLPLRFWVNLIKNPQFVFDIHKSSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNK 294

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 2105 LLYARDIPRYKQMVERYYADIRQTISASDQEMNSALAELSRNYSGDLNSLVALHELYKYINKYYDQIITALEEDPTAQKM 2184
Cdd:cd12790    295 LLYAKDIPNYKSWVERYYADIAKMPAISDQDMNAYLAEQSRLHLNEFNTLSALNELYSYVTKYKEEILTALEEDEFARKQ 374


                   ....*....
gi 1208037337 2185 QLGYRLQQI 2193
Cdd:cd12790    375 RLAYKLEQV 383
RasGAP_plexin_D1 cd12788
Ras-GTPase Activating Domain of plexin-D1; Plexins form a conserved family of transmembrane ...
 1630-2201 9.65e-142

Ras-GTPase Activating Domain of plexin-D1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-D1 has been identified as the receptor of Sema3E. It binds to Sema3E directly with high affinity. Sema3E is implicated in axonal path finding and inhibition of developmental and postischemic angiogenesis. Plexin-D1 is broadly expressed on tumor vessels and tumor cells in a number of different types of human tumors. The Plexin-D1 and Sema3E interaction inhibits tumor growth but promotes invasiveness and metastasis. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213348 [Multi-domain]  Cd Length: 419  Bit Score: 448.67  E-value: 9.65e-142
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1630 GIPFLDYKSYAERIFFP-----------------------GHRES-PLQRDLDIPECRRQTVEQGLVQLSNLLNSKLFLT 1685
Cdd:cd12788      2 GIPFLEYKHFVTRTFFPkcsslyeeryvlpsqennsqgprQVPEThPLLQEWKIPESCRPNMEEGITLFSTLLNNKHFLV 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1686 KFIHTLEIQRTFSPRDRAYVASLLTVSLHGKLEYFTDILKTLLNDLVEQYVAKNPKLMLRRTETVVEKLLTNWMSICLYA 1765
Cdd:cd12788     82 TFVHALEQQKDFAVRDRCNLASLLTIALHGKLEYYTSIMKDLLVDLIDASASKNPKLMLRRTESVVEKMLTNWMSICMYS 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1766 FVRDSVGEPLYMLFRGIKHQVDKGPVDwvtgkakytlndnrllredleyrtltlnaltqagvgaggaedsqgisakvldc 1845
Cdd:cd12788    162 YLRETVGEPFFLLLCAIKQQINKGSID----------------------------------------------------- 188

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1846 dtitqvkekildqiykgtpychrpdpdtldlewrsglaghlilsdedvtsvvqgtwkrlntlqhykvpdgatvalvprlt 1925
Cdd:cd12788        --------------------------------------------------------------------------------

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1926 khihrenqdyipgektpmledadegGIKlwhlvkpteepelpkhrrgslrdreraKAIPEIYLTRLLSMKGTLQKFVDDL 2005
Cdd:cd12788    189 -------------------------AIK---------------------------KVLPEIYLTRLLSTKGTLQKFLDDL 216

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 2006 FQVILST--NRPvPLAVKYFFDLLDEQAIHYGIADPETIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNVDAVLLVIAQ 2083
Cdd:cd12788    217 FQAILSIpeDRP-PLAVKYFFDFLEEQAEKRGITDPDTLHIWKTNSLPLRFWVNILKNPQFVFDIDKTDHMDACLSVIAQ 295

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 2084 TFMDSCTIADHKLGRDSPINKLLYARDIPRYKQMVERYYADIRQTISASDQEMNSALAELSRNYSGDLNSLVALHELYKY 2163
Cdd:cd12788    296 AFIDACSISDLQLGKDSPTNKLLYAKEIPEYRKIVQRYYQQIQEMPPLSEQEMNAHLAEESRKYRNEFNTNVAMAEIYKY 375

                          570       580       590
                   ....*....|....*....|....*....|....*...
gi 1208037337 2164 INKYYDQIITALEEDPTAQKMQLGYRLQQIAAAVENKV 2201
Cdd:cd12788    376 AKRYRAQIVSALESNPTARRTQLQHKFEQVIALMEDNI 413
Sema_plexin_B2 cd11276
The Sema domain, a protein interacting module, of Plexin B2; Plexin B2 serves as the receptor ...
 31-488 4.79e-122

The Sema domain, a protein interacting module, of Plexin B2; Plexin B2 serves as the receptor of Sema4C and Sema4G. By signaling the effect of Sema4C and Sema4G, the plexin B2 receptor plays important roles in neural tube closure and cerebellar granule cell development. Mice lacking Plexin B2 demonstrated defects in closure of the neural tube and disorganization of the embryonic brain. In developing kidney, Sema4C-Plexin B2 signaling modulates ureteric branching. Plexin B2 is expressed both in the pretubular aggregates and the ureteric epithelium in the developing kidney. Deletion of Plexin B2 results in renal hypoplasia and occasional double ureters. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200537 [Multi-domain]  Cd Length: 449  Bit Score: 393.76  E-value: 4.79e-122
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337   31 ATKFLHLSMDSESGTIYLGATNFLFQLTSDLLLENMVQTGPVLDSKDCLPPVSKLECPQAHHTDNHNKLLLVNTVQKELI 110
Cdd:cd11276      5 ATELNHLVVDPQTGRVYLGAVNALYQLDADLQLESRVETGPKKDNKKCTPPIEENQCTEAKMTDNYNKLLLLDSANKTLV 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  111 VCGSVHQGICEKRSLASIDHVLFRPESPGDTQYVAANDPNITTVGLIAYSKDE-VPLLFVGRGYTSRGVGggiPPITTRN 189
Cdd:cd11276     85 VCGSLFKGICSLRNLSNISEVIYYSDTSGEKSFVASNDEGVSTVGLISSLKPGnDRVFFVGKGNGSNDNG---KIISTRL 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  190 LrahggdvQATDSHSIF-SYEETAKLAVGRLSEYNHHFIKSFTYHSSVYFLFyRRDLKSQSREYkTYISRICLDDSHYYS 268
Cdd:cd11276    162 L-------QNYDDREVFeNYIDAATVKSAYVSRYTQQFRYAFEDNNYVYFLF-NQQLGHPDKNR-TLIARLCENDHHYYS 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  269 YVELPLLCQSKANTYSLLQAAYVTRPGKELAQ--GQLDTEGEVLFAAFSAWQASSGklseESALCVYTMEEVDRLTNWTR 346
Cdd:cd11276    233 YTEMDLNCRDGANAYNKCQAAYVSTPGKELAQnyGNSILSDKVLFAVFSRDEKDSG----ESALCMFPLKSINAKMEANR 308

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  347 DVCYMrdgKSEEGTEVAYIEYDVSSN--CVQLPADTLYAYPCGSDHTPSPMASRVPL-EAAPLLEKTEARLTAVAVNVED 423
Cdd:cd11276    309 EACYT---GTIDDRDVFYKPFHSQKDiiCGSHQQKNSKSFPCGSEHLPYPLGSRDELaLTAPVLQRGGLNLTAVTVAVEN 385

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1208037337  424 GHTIAFLGDSRGRLHKVYLGAQGEAhtYASVSIQVNSMVSGDLLFDQLQEHLFVMTQSMVVKVPI 488
Cdd:cd11276    386 GHTVAFLGTSDGRILKVHLSPDPEE--YNSILIEKNKPVNKDLVLDKTLEHLYIMTEDKVFRLPV 448
RasGAP_plexin_C1 cd12789
Ras-GTPase Activating Domain of plexin-C1; Plexins form a conserved family of transmembrane ...
 1627-2200 1.89e-115

Ras-GTPase Activating Domain of plexin-C1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-C1 has been identified as the receptor of semaphorin 7A, which plays regulatory roles in both the immune and nervous systems. Unlike other semaphorins which act as repulsive guidance cues, Sema7A enhances central and peripheral axon growth and is required for proper axon tract formation during embryonic development. Plexin-C1 is a potential tumor suppressor for melanoma progression. The expression of Plexin-C1 is diminished or absent in human melanoma cell lines. Cofilin, an actin-binding protein involved in cell migration, is a downstream target of Sema7A and Plexin-C1 signaling. Melanoma invasion and metastasis may be promoted through the loss of Plexin-C1 inhibitory signaling on cofilin activation. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213349 [Multi-domain]  Cd Length: 393  Bit Score: 372.27  E-value: 1.89e-115
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1627 VGTgIPFLDYKSYAERIFFPGHRESPLQRDLDIPECRRQT-VEQGLVQLSNLLNSKLFLTKFIHTLEIQRTFSPRDRAYV 1705
Cdd:cd12789      1 FGT-VPFLDYKHFALRTFFPESGGFTHIFTRDDPHDRDQTdKDESLTALDKLICNKSFLVTLIHTLEKQKNFSVKDRCLF 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1706 ASLLTVSLHGKLEYFTDILKTLLNDLVEQYVAKNPKLMLRRTETVVEKLLTNWMSICLYAFVRDSVGEPLYMLFRGIKHQ 1785
Cdd:cd12789     80 ASFLTIALQTKLVYLTEILEVLTKDLMDQSSNAQPKLLLRRTESVVEKLLTNWMSVCLSGFLRETVGEPFYLLVTTLNQK 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1786 VDKGPVDWVTGKAKytlndnrllredleyrtltlnaltqagvgaggaedsqgisakvldcdtitqvkekildqiykgtpy 1865
Cdd:cd12789    160 INKGPVDVIKFKVK------------------------------------------------------------------ 173

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1866 chrpdpdtldlewrsglaghlilsdedvtsvvqgtwkrlntlqhykvpdgatvalvprltkhihrenqdyipgektpmle 1945
Cdd:cd12789        --------------------------------------------------------------------------------

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1946 dadeggiklwhlvkpteepelpkhrrgslrdrerakaipEIYLTRLLSMKGTLQKFVDDLFQVI--LSTNRPvPLAVKYF 2023
Cdd:cd12789    174 ---------------------------------------EMYLTKLLSTKVAIHSVVEKLFRSIwsLPNNKA-PVAIKYF 213

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 2024 FDLLDEQAIHYGIADPETIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNVDAVLLVIAQTFMDSCTIADHKLGRDSPIN 2103
Cdd:cd12789    214 FDFLDAQAENKKITDPDVLHIWKTNSLPLRFWVNILKNPQFVFDIKKTPHLDGCLSVIAQAFMDSFSLSEQHLGKEAPTN 293

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 2104 KLLYARDIPRYKQMVERYYADIRQTISASDQEMNSALAELSRNYSGDLNSLVALHELYKYINKYYDQIITALEEDPTAQK 2183
Cdd:cd12789    294 KLLYAKDIPQYKEEVKSYYKAIRDLPPLSSSELEEFLTQESKKHENEFNEEVALMEIYKYIVKYFDEILNKLERERGLEE 373

                          570
                   ....*....|....*..
gi 1208037337 2184 MQlgYRLQQIAAAVENK 2200
Cdd:cd12789    374 VQ--KQLLHVKALFDEK 388
Sema_plexin_like cd11236
The Sema domain, a protein interacting module, of Plexins and MET-like receptor tyrosine ...
 34-488 5.72e-115

The Sema domain, a protein interacting module, of Plexins and MET-like receptor tyrosine kinases; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestor of semaphorins. Ligand binding activates signal transduction pathways controlling axon guidance in the nervous system and other developmental processes including cell migration and morphogenesis, immune function, and tumor progression. Plexins are divided into four types (A-D) according to sequence similarity. In vertebrates, type A Plexins serve as the co-receptors for neuropilins to mediate the signalling of class 3 semaphorins except Sema3E, which signals through Plexin D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B. Plexin C1 serves as the receptor of Sema7A and plays regulation roles in both immune and nervous systems. This family also includes the Met and RON receptor tyrosine kinases. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200497 [Multi-domain]  Cd Length: 401  Bit Score: 371.28  E-value: 5.72e-115
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337   34 FLHLSMDSESGTIYLGATNFLFQLTSDLLLENMVQTGPVLDSKDCLPPVSKLECPQAHHTDNHNKLLLVNTVQKELIVCG 113
Cdd:cd11236      2 FNHLAVDNSTGRVYVGAVNRLYQLDSSLLLEAEVSTGPVLDSPLCLPPGCCSCDHPRSPTDNYNKILLIDYSSGRLITCG 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  114 SVHQGICEKRSLASIDHVLFRpespgDTQYVAANDPNITTVGLIAYSKD-EVPLLFVGRGYTSRGVGGGIPPITTRNLRa 192
Cdd:cd11236     82 SLYQGVCQLRNLSNISVVVER-----SSTPVAANDPNASTVGFVGPGPYnNENVLYVGATYTNNGYRDYRPAVSSRSLP- 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  193 hggdvqATDSHSIFSYEETAKLAVGRLS--EYNHHFIKSFTYHSSVYFLFYRRDLKSQSREYKTYISRICLDDSHYYSYV 270
Cdd:cd11236    156 ------PDDDFNAGSLTGGSAISIDDEYrdRYSIKYVYGFSSGGFSYFVTVQRKSVDDESPYISRLVRVCQSDSNYYSYT 229

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  271 ELPLLCQSKANT-YSLLQAAYVTRPGKELAQG-QLDTEGEVLFAAFSAWQASSGKLSEESALCVYTMEEVDRltnwtrdv 348
Cdd:cd11236    230 EVPLQCTGGDGTnYNLLQAAYVGKAGSDLARSlGISTDDDVLFGVFSKSKGPSAEPSSKSALCVFSMKDIEA-------- 301

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  349 cymrdgkseegtevAYIEYdvssncvqlpadtlyaypcgsdhtpSPMASRVPLEAAPLLEktEARLTAVAVNVEDGHTIA 428
Cdd:cd11236    302 --------------AFNDN-------------------------CPLGGGVPITTSAVLS--DSLLTSVAVTTTRNHTVA 340

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  429 FLGDSRGRLHKVYLGAQGEAHTYASVSIQVNSMVSGDLLFDQLQEHLFVMTQSMVVKVPI 488
Cdd:cd11236    341 FLGTSDGQLKKVVLESSSSATQYETLLVDSGSPILPDMVFDPDGEHLYVMTPKKVTKVPV 400
Sema smart00630
semaphorin domain;
34-456 1.03e-68

semaphorin domain;


Pssm-ID: 214747 [Multi-domain]  Cd Length: 390  Bit Score: 237.65  E-value: 1.03e-68
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337    34 FLHLSMDSESGTIYLGATNFLFQLTSDLLLENMVQTGPVLDSKDCLPPVSKlecPQAHHTDNHNKL-LLVNTVQKELIVC 112
Cdd:smart00630    1 LQHLLLDEDNGTLYVGARNRLYQLSLNLILEAELKTGPVLSSPDCEECVSK---GKDPPTDCVNYIrLLLDYNEDRLLVC 77

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337   113 GS-VHQGICEKRSLasidhvlfrpespgdtqyvaandpnittvgliayskdevPLLFVGRGYTSRGVGGGIPP-ITTRNL 190
Cdd:smart00630   78 GTnAFQPVCRLRNL---------------------------------------GELYVGTVADFSGSDPAIPRsLSVRRL 118

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337   191 RAHGGDVQATDSHSIFSYeetaklavgrlseYNHHFIKSFTYHSSVYFLFYRR--DLKSQSREYKTYISRICLDD----- 263
Cdd:smart00630  119 KGTSGVSLRTVLYDSKWL-------------NEPNFVYAFESGDFVYFFFRETavEDDNCGKAVHSRVARVCKNDvggpr 185

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337   264 ---SHYYSYVELPLLCQSKANT---YSLLQAAYVTRPGKElaqgqldtEGEVLFAAFSAWQASSGKlseeSALCVYTMEE 337
Cdd:smart00630  186 sldKKWTSFLKARLECSVPGEDpfyFNELQAAFLLPPGSE--------SDDVLYGVFSTSSNPIPG----SAVCAFSLSD 253

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337   338 VDRLTNWTRDVCYMRDGKSEEGTEvAYIEYDVSSNCVQLPADTLyAYPC----GSDHTPSPMASRVPLEAAPLLEKT--E 411
Cdd:smart00630  254 INAVFNGPFKECETSTSQWLPYSR-GKVPYPRPGTCPNKPPSSK-DLPDetlnFIKSHPLMDEVVQPLTGRPLFVKTdsN 331

                           410       420       430       440       450
                    ....*....|....*....|....*....|....*....|....*....|.
gi 1208037337   412 ARLTAVAVNVED---GHTIAFLGDSRGRLHKVYL---GAQGEAHTYASVSI 456
Cdd:smart00630  332 YLLTSIAVDRVAtdgNYTVLFLGTSDGRILKVVLsesSSSSESVVLEEISV 382
Sema_plexin_A2 cd11272
The Sema domain, a protein interacting module, of Plexin A2; Plexin A2 serves as a receptor ...
 24-526 6.68e-68

The Sema domain, a protein interacting module, of Plexin A2; Plexin A2 serves as a receptor for class 6 semaphorins. Interactions between Plexin A2, A4 and semaphorins 6A and 6B control the lamina-restricted projection of hippocampal mossy fibers. Sema6B also repels the growth of mossy fibers in a Plexin A4 dependent manner. Plexin A2 does not suppress Sema6B function. In addition, studies have shown that Plexin A2 may be related to anxiety and other psychiatric disorders. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200533 [Multi-domain]  Cd Length: 515  Bit Score: 239.45  E-value: 6.68e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337   24 YVTF--SHNATKFLHLSMDSESGTIYLGATNFLFQLTSDLLLENMVQTGPVLDSKDCLPPVSKLECPQAHH-TDNHNKLL 100
Cdd:cd11272      1 FNTFhsENRDWTFNHLTVHQSTGAVYVGAINRVYKLSGNLTILVAHKTGPEEDNKSCYPPLIVQPCSEVLTlTNNVNKLL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  101 LVNTVQKELIVCGSVHQGICEKRSLASIdHVLFRPeSPGDTQYVAANDPNITTVGLIAYSKDEVPLLFVGRGytsrgVGG 180
Cdd:cd11272     81 IIDYSENRLLACGSLYQGVCKLLRLDDL-FILVEP-SHKKEHYLSSVNKTGTMYGVIVRSEGEDGKLFIGTA-----VDG 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  181 G---IPPITTRNLRahggdvQATDSHSIFSYEETAKL----------AVGRLSEYNHHFIKSFTYHSSVYFLFYRRDL-- 245
Cdd:cd11272    154 KqdyFPTLSSRKLP------RDPESSAMLDYELHSDFvsslikipsdTLALVSHFDIFYIYGFASGNFVYFLTVQPETpe 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  246 -----KSQSREYKTYISRICLDDSHYYSYVELPLLCQSKANTYSLLQAAYVTRPGKELAQG-QLDTEGEVLFAAFSAWQA 319
Cdd:cd11272    228 gvsinSAGDLFYTSRIVRLCKDDPKFHSYVSLPFGCVRGGVEYRLLQAAYLSKPGEVLARSlNITAQEDVLFAIFSKGQK 307

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  320 SSGKLSEESALCVYTMEEVDRLTNWTRDVCYMRDGKSEEGTevaYIEYDVSSNCVQLPADTLYaypCGSDhTPSPMASRV 399
Cdd:cd11272    308 QYHHPPDDSALCAFPIRAINAQIKERLQSCYQGEGNLELNW---LLGKDVQCTKAPVPIDDNF---CGLD-INQPLGGST 380

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  400 PLEAAPLLEKTEARLTAVAVNVEDGHTIAFLGDSRGRLHKVYlgAQGEAH---TYASVSI-QVNSMVSGDLLFDQLQEHL 475
Cdd:cd11272    381 PVEGVTLYTSSRDRLTSVASYVYNGYSVVFVGTKSGKLKKIR--ADGPPHggvQYEMVSVfKDGSPILRDMAFSIDHKYL 458

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1208037337  476 FVMTQSMVVKVPIMECSLYLDCESCLALKDPYCGWCVLQGRCSRRSECLRS 526
Cdd:cd11272    459 YVMSERQVSRVPVESCEQYTTCGECLSSGDPHCGWCALHNMCSRRDKCQRA 509
Sema_plexin_A cd11244
The Sema domain, a protein interacting module, of Plexin A; Plexins serve as receptors of ...
 24-488 3.18e-61

The Sema domain, a protein interacting module, of Plexin A; Plexins serve as receptors of semaphorins and may be the ancestor of semaphorins. Members of the Plexin A subfamily are receptors for Sema1s, Sema3s, and Sema6s, and they mediate diverse biological functions including axon guidance, cardiovascular development, and immune function. Guanylyl cyclase Gyc76C and Off-track kinase (OTK), a putative receptor tyrosine kinase, modulate Sema1a-Plexin A mediated axon repulsion. Sema3s do not interact directly with plexin A receptors, but instead bind Neuropilin-1 or Neuropilin-2 toactivate neuropilin-plexin A holoreceptor complexes. In contrast to Sema3s, Sema6s do not require neuropilins for plexin A binding. In the complex, plexin As serve as signal-transducing subunits. An increasing number of molecules that interact with the intracellular region of Plexin A have been identified; among them are IgCAMs (in axon guidance events) and Trem2-DAP12 (in immune responses). The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200505 [Multi-domain]  Cd Length: 470  Bit Score: 218.54  E-value: 3.18e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337   24 YVTFS--HNATKFLHLSMDSESGTIYLGATNFLFQLTSDLLLENMVQTGPVLDSKDCLPPVSKLECPQA-HHTDNHNKLL 100
Cdd:cd11244      1 FVTFRgePRDWSFNHLTVHRRTGEVYVGAINRVYKLSSNLTVLVTHETGPVEDNPKCYPPPIVQTCNEPlTTTNNVNKLL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  101 LVNTVQKELIVCGSVHQGICEKRSLASidhvLFRPESPGDTQ--YVAANDPNITTVGLIAYSKDEVPLLFVGRGYTsrGV 178
Cdd:cd11244     81 LIDYSENRLIACGSLYQGVCKLLRLED----LFKLGEPHHKKehYLSGVNESGTMFGVIVSYSNGDDKLFIGTAVD--GK 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  179 GGGIPPITTRNLRAHggdvqaTDSHSIFSYE-------ETAKLAVGRLSEYNH---HFIKSFTYHSSVYFLFYRRDLKSQ 248
Cdd:cd11244    155 SEYFPTLSSRKLTAD------EESDGMFAYVyhdefvsSQIKIPSDTLSIIPDfdiYYVYGFSSGNFVYFLTLQPETQLT 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  249 SRE------YKTYISRICLDDSHYYSYVELPLLCQSKANTYSLLQAAYVTRPGKELAQG-QLDTEGEVLFAAFSAWQASS 321
Cdd:cd11244    229 PGDstgeqfYTSKIVRLCKDDTKFYSYVEFPIGCTRDGVEYRLLQAAYLSKPGKALAQAlGISEDEDVLFTIFSKGQKNR 308

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  322 GKLSEESALCVYTMEEVDRLTNWTRDVCYMRDGKseegTEVAYI-EYDVSSNCVQLPADTLYaypCGSDHTpSPMASRVP 400
Cdd:cd11244    309 MKPPDESALCLFTLKQINLRIKERLQSCYRGEGK----LSLPWLlNKDLPCINAPLQIDDNF---CGLDMN-QPLGGSDM 380

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  401 LEAAPLLEKTEARLTAVAVNVEDGHTIAFLGDSRGRLHKVYL-GAQGEAHTYASVSIQVNSMVSGDLLFDQLQEHLFVMT 479
Cdd:cd11244    381 VEGIPLFTDDRDRMTSVAAYVYKGHSVVFVGTKSGKLKKIRVdGPPHNALQYETVQVVEGSPILRDMAFSPDHQYLYIMS 460


                   ....*....
gi 1208037337  480 QSMVVKVPI 488
Cdd:cd11244    461 ERQVTRVPV 469
Plexin_RBD pfam20170
Plexin cytoplasmic RhoGTPase-binding domain; This entry represents the RhoGTPase-binding ...
 1802-1920 4.84e-57

Plexin cytoplasmic RhoGTPase-binding domain; This entry represents the RhoGTPase-binding domain found in the cytoplasmic domain of plexins.


Pssm-ID: 466321  Cd Length: 113  Bit Score: 193.18  E-value: 4.84e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1802 LNDNRLLREDLEYRTLTLNALTQAGvgaggaEDSQGISAKVLDCDTITQVKEKILDQIYKGTPYCHRPDPDTLDLEWRSG 1881
Cdd:pfam20170    1 LSEDKLLREQIDYKTLTLNVIFEEG------EVSESVPVKVLDCDTISQVKEKILDAVYKNTPYSQRPSIDDVDLEWRHG 74

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1208037337 1882 LAGHLILSDEDVTSVVQGTWKRLNTLQHYKVPDGATVAL 1920
Cdd:pfam20170   75 RGGRLILQDEDSTSKVEGGWKKLNTLAHYKVPDGATLAL 113
Sema_plexin_A1 cd11271
The Sema domain, a protein interacting module, of Plexin A1; Plexin A1 is found in both the ...
 26-488 7.01e-56

The Sema domain, a protein interacting module, of Plexin A1; Plexin A1 is found in both the nervous and immune systems. Its external Sema domain is also shared by semaphorin proteins. In the nervous system, Plexin A1 mediates Sema3A axon guidance function by interacting with the Sema3A coreceptor neuropilin, resulting in actin depolarization and cell repulsion. In the immune system, Plexin A1 mediates Sema6D signaling by binding to the Sema6D-Trem2-DAP12 complex on immune cells and osteoclasts to promote Rac activation and DAP12 phosphorylation. In gene profiling experiments, Plexin A1 was identified as a CIITA (class II transactivator) regulated gene in primary dendritic cells (DCs). The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200532 [Multi-domain]  Cd Length: 474  Bit Score: 203.27  E-value: 7.01e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337   26 TFSHNATKFLHLSMDSESGTIYLGATNFLFQLTSDLLLENMVQTGPVLDSKDCLPPVSKLECPQA-HHTDNHNKLLLVNT 104
Cdd:cd11271      6 TFTASDWSLTHLVVHNKTGEVYVGAVNRIYKLSNNLTLLRTHVTGPVEDNEKCYPPPSVQSCPHGlGTTNNVNKLLLVDY 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  105 VQKELIVCGSVHQGICEKRSLASidhvLFRPESPGDTQ--YVAANDPNITTVGLIAYSKDEVPLLFVGRGYTsrGVGGGI 182
Cdd:cd11271     86 AANRLIACGSASQGICQFLRLDD----LFKLGEPHHRKehYLSSVNESGTMSGVIIEVGNGQNKLFVGTPID--GKSEYF 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  183 PPITTRNLRAHGGDVQATDshsiFSYEE---TAKLAV-----GRLSEYNHHFIKSFTYHSSVYFLFYRRDLKSQSRE--- 251
Cdd:cd11271    160 PTLSSRKLMANEENAEMFG----FVYQDefvSSQLKIpsdtlSKFPTFDIYYVYSFSSEQFVYYLTLQLDTQLTSPDstg 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  252 ---YKTYISRICLDDSHYYSYVELPLLCQSKANTYSLLQAAYVTRPGKELAQGQLDTEGE-VLFAAFSAWQASSGKLSEE 327
Cdd:cd11271    236 eqfFTSKIVRLCVDDPKFYSYVEFPIGCEQDGVEYRLIQDAYLSKPGKALAKQLGISEREdILFTVFSQGQKNRVKPPKE 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  328 SALCVYTMEEVDRLTNWTRDVCYMRDGKseegTEVAYIeYDVSSNCVQLPADTLYAYpCGSDHTpSPMASRVPLEAAPLL 407
Cdd:cd11271    316 SVLCLFTLKKIKDKIKERIQSCYRGEGK----LSLPWL-LNKELGCINSPLQIDDNF-CGQDFN-QPLGGTVTIEGTPLF 388

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  408 EKTEARLTAVAVNVEDGHTIAFLGDSRGRLHKVYLGAQGE----AHTYASVSIQVNSMVSGDLLFDQLQEHLFVMTQSMV 483
Cdd:cd11271    389 VDKEDGMTSVAAYDYRGRTVVFAGTRSGRIKKILVDLSAPssrpALQYENVVAHEGSPILRDLVLSPDRQYIYAMTEKQV 468


                   ....*
gi 1208037337  484 VKVPI 488
Cdd:cd11271    469 TRVPV 473
Sema_plexin_A4 cd11274
The Sema domain, a protein interacting module, of Plexin A4; Plexin A4 forms a receptor ...
 24-492 7.53e-55

The Sema domain, a protein interacting module, of Plexin A4; Plexin A4 forms a receptor complex with neuropilins (NRPs) and transduces signals for class 3 semaphorins in the nervous system. It regulates facial nerve development by functioning as a receptor for Sema3A/NRP1. Both plexins A3 and A4 are essential for normal sympathetic development. They function both cooperatively, to regulate the migration of sympathetic neurons, and differentially, to guide sympathetic axons. Plexin A4 is also expressed in lymphoid tissues and functions in the immune system. It negatively regulates T lymphocyte responses. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200535 [Multi-domain]  Cd Length: 473  Bit Score: 200.18  E-value: 7.53e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337   24 YVTF--SHNATKFLHLSMDSESGTIYLGATNFLFQLTSDLLLENMVQTGPVLDSKDCLPPVSKLEC-PQAHHTDNHNKLL 100
Cdd:cd11274      1 FITFtgDQTEWTFNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHQTGPDEDNPKCYPPRIVQTCnEPLTLTNNINKML 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  101 LVNTVQKELIVCGSVHQGICEkrsLASIDHvLFRPESPGDTQ--YVAANDPNITTVGLIAYSKDEVPLLFVGRGYTsrGV 178
Cdd:cd11274     81 LIDYKENRLIACGSLYQGICK---LLRLDD-LFKLGEPFHKKehYLSGVNESGSVFGVIVSYSNLDDKLFIATAVD--GK 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  179 GGGIPPITTRNLrahggdVQATDSHSIFSY----EETAKL------AVGRLSEYNHHFIKSFTYHSSVYFLFYRRDL--- 245
Cdd:cd11274    155 PEYFPTISSRKL------TKNSEADGMFAYvfhdEFVASMikipsdTFTIIPDFDIYYIYGFSSGNFVYFLTLQPEMisp 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  246 -KSQSRE--YKTYISRICLDDSHYYSYVELPLLCQSKANTYSLLQAAYVTRPGKELAQG-QLDTEGEVLFAAFSAWQASS 321
Cdd:cd11274    229 pGSTTKEqvYTSKLVRLCKEDTAFNSYVEVPIGCEKNGVEYRLLQAAYLSKAGAILARSlGVGPDDDILFTVFSKGQKRK 308

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  322 GKLSEESALCVYTMEEVDRLTNWTRDVCYmrdgKSEEGTEVAYIEY-DVSSNCVQLPADTLYaypCGSDHTpSPMASRVP 400
Cdd:cd11274    309 MKSLDESALCIFVLKEINDRIKDRLQSCY----RGEGTLDLAWLKVkDIPCSSALLTIDDNF---CGLDMN-APLGVSEM 380

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  401 LEAAPLLEKTEARLTAVAVNVEDGHTIAFLGDSRGRLHKVYL-GAQGEAHTYASVSIQVNSMVSGDLLFDQLQEHLFVMT 479
Cdd:cd11274    381 VRGLPVFTEDRDRMTSVIAYVYKNHSLAFVGTKSGKLKKIRVdGTTKNALQYETVQVVDTGPILRDMAFSKDHEQLYIMS 460

                          490
                   ....*....|...
gi 1208037337  480 QSMVVKVPIMECS 492
Cdd:cd11274    461 EKQLTRVPVESCG 473
Sema_plexin_A3 cd11273
The Sema domain, a protein interacting module, of Plexin A3; Plexin-A3 forms a receptor ...
 26-488 2.12e-54

The Sema domain, a protein interacting module, of Plexin A3; Plexin-A3 forms a receptor complex with neuropilin-2 and transduces signals for class 3 semaphorins in the nervous system. Both plexins A3 and A4 are essential for normal sympathetic neuron development. They function cooperatively to regulate the migration of sympathetic neurons, and differentially to guide sympathetic axons. Both plexins A3 and A4 are not required for guiding neural crest precursors prior to reaching the sympathetic anlagen. Plexin A3 is a major driving force for intraspinal motor growth cone guidance. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200534 [Multi-domain]  Cd Length: 469  Bit Score: 198.62  E-value: 2.12e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337   26 TFSHNATKFLHLSMDSESGTIYLGATNFLFQLTSDLLLENMVQTGPVLDSKDCLPPVSKLECPQA-HHTDNHNKLLLVNT 104
Cdd:cd11273      5 AFVVTDTTLTHLAVHRVTGEVFVGAVNRVYKLSANLTELRAHVTGPVEDNARCYPPPSVRVCAHRlAPVDNVNKLLLVDY 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  105 VQKELIVCGSVHQGICEKRSLASIDHvLFRPESPGDTQYVAANDPNiTTVGLIAYSKDEVPLLFVGRGytsrgVGGG--- 181
Cdd:cd11273     85 AGNRLVACGSIWQGVCQFLRLEDLFK-LGEPHHRKEHYLSGAQEPD-SMAGVIVEQGKGPSKLFVGTA-----IDGKsey 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  182 IPPITTRNLRAhggDVQATDSHSIFSYEE----TAKLAVGRLSEY---NHHFIKSFTYHSSVYFLFYRRDLK------SQ 248
Cdd:cd11273    158 FPTLSSRKLIS---DEDSADMFSLVYQDEfvssQIKIPSDTLSLYpafDIYYVYGFVSASFVYFLTLQLDTQqtlldtAG 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  249 SREYKTYISRICLDDSHYYSYVELPLLCQSKANTYSLLQAAYVTRPGKELAQGQLDTEGE-VLFAAFSAWQASSGKLSEE 327
Cdd:cd11273    235 EKFFTSKIVRMCANDTEFYSYVEFPLGCSKDGVEYRLVQAAHLAKPGLLLAQALGVPEDEdVLFTIFSQGQKNRASPPRE 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  328 SALCVYTMEEVDRLTNWTRDVCYMRDGKseegtevayieydvssncVQLPADTLYAYPCgsDHTP-------------SP 394
Cdd:cd11273    315 TILCLFTLSNINAHIRERIQSCYRGEGT------------------LSLPWLLNKELPC--INTPmqingnfcglvlnQP 374

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  395 MASRVPLEAAPLLEKTEARLTAVAVNVEDGHTIAFLGDSRGRLHKVYLGAQGEAHTYASVSIQVNSMVSGDLLFDQLQEH 474
Cdd:cd11273    375 LGGLHVIEGLPLLADSTDGMASVAAYTYRQHSVVFIGTRSGSLKKVRVDGFQDAHLYETVPVVDGSPILRDMVFSPDHRY 454

                          490
                   ....*....|....
gi 1208037337  475 LFVMTQSMVVKVPI 488
Cdd:cd11273    455 IYLLSEKQVSQLPV 468
Sema_plexin_D1 cd11247
The Sema domain, a protein interacting module, of Plexin D1; Plexins are known as semaphorin ...
 38-486 1.59e-40

The Sema domain, a protein interacting module, of Plexin D1; Plexins are known as semaphorin receptors and Plexin D1 has been identified as the receptor of Sema3E. It binds to Sema3E directly with high affinity. Sema3E is implicated in axonal path finding and inhibition of developmental and post-ischemic angiogenesis. Plexin D1 is broadly expressed on tumor vessels and tumor cells in a number of different types of human tumors. Plexin D1-Sema3E interaction inhibits tumor growth but promotes invasiveness and metastasis. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200508 [Multi-domain]  Cd Length: 483  Bit Score: 158.09  E-value: 1.59e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337   38 SMDSESGTIYLGATNFLFQLT-SDLLLENMVQTGPVLDSKDCLPPvsklECPQA--HH----TDNHNKLLLVNTVQKELI 110
Cdd:cd11247     15 ALDGGRGRLYLAAVNRLYQLSgLVLALEAEAAVGPVLDSPLCHAP----QLPQAtcEHprtlTDNYNKILQPDPEQGVLV 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  111 VCGSVHQGICEKRSLASIDHVLFRPESPGDTQY-----VAANDPNITTVGLIAYSKDEV--PLLFVGRGYTSRGVGG--- 180
Cdd:cd11247     91 VCGSIYQGLCQLRRLYNISAVAVRFPVDGDTVFpsmlnVAANHPNASTVGLVLWPRGGGggLRLLVGATYTGYGSGFfpr 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  181 ----------GIPPITTRNLRAHGG-------DVQATDShSIFSYEETAKlAVGRLS---EYNHHFIKSFTYhssvyfLF 240
Cdd:cd11247    171 nrsledhrfeNTPEIAIRALNTRGDlaklftfDINPSDD-NIFKIKQGAK-ARHKLSfvrAFLQHFLQPYAY------LA 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  241 YRRDLKSQSREYK--TYISRICLDDSH----------YYSYVELPLLCqskANTYSLLQAAYVTRPGKELaqgqldtege 308
Cdd:cd11247    243 MNGEANAAGKESQppSLLARICLPGRAppppgeakklTESYIQLGLRC---EGAYTRLVSVFPARVEEEQ---------- 309

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  309 vLFAAFSAWQASsgklseESALCVYTMEEVDRLTNWTRDVCYMrdgkSEEGTEVAYIEYDVSS--------NCVQLPADT 380
Cdd:cd11247    310 -LFAVFERAGGA------PAALCAFRFAEVEEPIRAARTACFV----SPAAGVVTVLDSVVQGtgpacerkLNIQLQPEQ 378

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  381 LyayPCGSDHTPSPMASRVPLEAAPLLekTEARLTAVAVNVEDGHTIAFLGDSRGRLHKVYLGAQGEAHTYASVSIQVNS 460
Cdd:cd11247    379 L---DCGAAHLQHPLAILQPLKATPVF--RAPGLTSVAVASVNNYTVVFLGTVSGRLLKINLDESMQVVSRRSVTVAYGE 453

                          490       500
                   ....*....|....*....|....*....
gi 1208037337  461 MVSGDLLFDQLQE-HLFVMT--QSMVVKV 486
Cdd:cd11247    454 PVHHVMQFDPSDStYLYLMTshQMTRVKV 482
Sema_MET_like cd11248
The Sema domain, a protein interacting module, of MET and RON receptor tyrosine kinases; This ...
 43-488 2.58e-31

The Sema domain, a protein interacting module, of MET and RON receptor tyrosine kinases; This family includes MET and RON receptor tyrosine kinases. MET is encoded by the c-met protooncogene. MET is the receptor for hepatocyte growth factor/scatter factor (HGF/SF). HGF/SF and MET regulates multiple cellular events and are essential for the development of several tissues and organs, including the placenta, liver, and several groups of skeletal muscles. RON receptor tyrosine kinase is a Macrophage-stimulating protein (MSP) receptor. Upon binding of MSP, RON is activated via autophosphorylation within its kinase catalytic domain, resulting in a variety of effects including proliferation, tubular morphogenesis, angiogenesis, cellular motility and invasiveness. By interacting with downstream signaling molecules, it regulates macrophage migration, phagocytosis, and nitric oxide production. MET and RON receptors have been implicated in cancer development and migration. They are composed of alpha-beta heterodimers. The extracellular alpha chain is disulfide linked to the beta chain, which contains an extracellular ligand-binding region with a Sema domain, a PSI domain and four IPT repeats, a transmembrane segment, and an intracellular catalytic tyrosine kinase domain. The Sema domain is necessary for receptor dimerization and activation.


Pssm-ID: 200509 [Multi-domain]  Cd Length: 467  Bit Score: 130.23  E-value: 2.58e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337   43 SGTIYLGATNFLFQLTSDLLLENMVQTGPVLdSKDCLPPVSKleCPQAHH---TDNHNKLLLVNTVQ-KELIVCGSVHQG 118
Cdd:cd11248     19 STEVYVAAQNVIYALNPDLQKVWEYKTGPVG-SPDCQTCQDC--SSGADPgvpKDTDNMVLVLETYYdDYLYSCGSTQNG 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  119 IC-----EKR-SLASIDHVLFRPE---SPGDTQYVAAndPNITTVGLIaySKDEVPLLFVGRGYTSRgVGGGIPP--ITT 187
Cdd:cd11248     96 VCyrhvlEDGaDIQSEVHCLFSKKnnsPSYCPDCVAS--PLGTKVTNV--ESGRTIYFFVANSVNSS-LAGSFPPhsISV 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  188 RNLRAHGGDVqatdsHSIFSYeetAKLAVGRLSEYNHHFIKSFTYHSSVYFLFYRRDLKSQ-SREYKTYISRICLDDSHY 266
Cdd:cd11248    171 RRLKEDGFGF-----LSDQSY---LDVLPSLRDSYPIKYVYSFHSGPFVYFLTVQRESLTKpSSAFHTRLVRLCSSDSEI 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  267 YSYVELPLLC--------QSKANT--YSLLQAAYVTRPGKELA-QGQLDTEGEVLFAAFSAWQASSGKLSEESALCVYTM 335
Cdd:cd11248    243 WRYREMPLECiftpkrrrRSTEEDvvYNVLQAAHVSKVGADLAdELGASEGDDILFGVFARSKPDSGEPMPNSALCAFPI 322

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  336 EEVDRLTNWTRDVCYMRDGKSEEGtevayieydvsSNCVQLPADTL--YAYPCGS--DHTPSPMAS---RVPLEAAPLle 408
Cdd:cd11248    323 KYVNDAIEKGVEKCCTSGLEHFSG-----------SLCHFQPCPTCpgESSSCEAtcKEYRTEVTKpyqRVDLFNGQM-- 389

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  409 kTEARLTAVAVNVEDGHTIAFLGDSRGRLHKVYLGAQG-EAHT-YASVSIQVNSMVS-----GDLLFdqlqehlfvMTQS 481
Cdd:cd11248    390 -SNVLLTSILVTTIGNHTVAHLGTSDGRVLQVVLSRSGpIPHVnFSLDSQPVSREVAvlssnGSLLF---------VTGD 459


                   ....*..
gi 1208037337  482 MVVKVPI 488
Cdd:cd11248    460 KITKVPL 466
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1139-1230 5.98e-28

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 109.33  E-value: 5.98e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1139 PLIHSVYPLSGPVEGGTRITITGSNLGQKHQDIAETVTVAGIPCAVDAQEYEISSSIVCITGGSWTERFGHiVVEVPGGG 1218
Cdd:cd01180      1 PVITEFFPLSGPLEGGTRLTICGSNLGLRKNDVRHGVRVGGVPCNPEPPEYSSSEKIVCTTGPAGNPVFNG-PVEVTVGH 79

                           90
                   ....*....|....*
gi 1208037337 1219 ---RGVSGHVFTYQN 1230
Cdd:cd01180     80 gsfRTESSEGFSFVD 94
Sema_MET cd11278
The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor ...
 44-488 6.45e-28

The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR); MET is encoded by the c-met protooncogene. MET is a receptor tyrosine kinase that binds its ligand, hepatocyte growth factor/scatter factor (HGF/SF). HGF/SF and MET are essential for the development of several tissues and organs, including the placenta, liver, and several groups of skeletal muscles. It also plays a major role in the abnormal migration of cancer cells as a result of overexpression or MET mutations. MET is composed of an alpha-beta heterodimer. The extracellular alpha chain is disulfide linked to the beta chain, which contains an extracellular ligand-binding region with a Sema domain, a PSI domain and four IPT repeats, a transmembrane segment, and an intracellular catalytic tyrosine kinase domain. The cytoplasmic C-terminal region acts as a docking site for multiple protein substrates, including Grb2, Gab1, STAT3, Shc, SHIP-1 and Src. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. The Sema domain of Met is necessary for receptor dimerization and activation.


Pssm-ID: 200539 [Multi-domain]  Cd Length: 492  Bit Score: 120.36  E-value: 6.45e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337   44 GTIYLGATNFLFQLTSDLLLENMVQTGPVLDSKDCLPP---VSKLECPQAHHTDNHNKLLLVNTV-QKELIVCGSVHQGI 119
Cdd:cd11278     36 HHIYVGAVNKIYVLNEDLQKVSEYKTGPVLEHPDCFPCqdcSDKANLSNGVWKDNVNMALFVETYyDDQLISCGSVNRGT 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  120 CEKRSL--------ASIDHVLFRPESPGDtqyvAANDPN--ITTVG--LIAYSKDEVPLLFVGRGYTsrgvGGGIPP--- 184
Cdd:cd11278    116 CQRHVFphdhpadiQSEVHCIYSPQIEEE----PDQCPDcvVSTLGskVLVTVKDRFVNFFVGNTIN----SSYFPDhpl 187

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  185 --ITTRNLR-AHGGDVQATDShsifSYEETakLAVGRLSeYNHHFIKSFTYHSSVYFLFYRRD-LKSQSreYKTYISRIC 260
Cdd:cd11278    188 hsISVRRLKeTQDGFEFLTDQ----SYIDV--LPEFRDS-YPIKYVHAFESNNFVYFLTVQREsLDSQT--FHTRIIRFC 258

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  261 LDDSHYYSYVELPLLC---------QSKANTYSLLQAAYVTRPGKELAQGQ-LDTEGEVLFAAFSAWQASSGKLSEESAL 330
Cdd:cd11278    259 SIDSELRSYMEMPLECiftekrrkrSTKKEVFNILQAAYVSKPGAQLAREMgASLNDDILFGVFAQSKPDSAEPMNRSAV 338

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  331 CVYTMEEVDRLTNWTRDVCYMRDGKSEEGTEVAY-IEYDVSSNcvqlpadtlyAYPCGSDHTPSPMASRVPLEAAPLL-- 407
Cdd:cd11278    339 CAVSIKTINEFFNKIVDKQNVKCLQHFYGKNHEHcFNRTFLRN----------ASYCEARRDEYRVEVTTALQRVDLFmg 408

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  408 EKTEARLTAVAVNVEDGHTIAFLGDSRGRLHKVYLGAQGEahTYASVSIQVNSM-VSGDLLFDQLQE---HLFVMTQSMV 483
Cdd:cd11278    409 QFSNVLLTSISVFTKGDLTIANLGTSEGRFMQVVVSRSGP--STPHVNFLLDSHpVSPEVIVEHTLNqngYTLVITGKKI 486


                   ....*
gi 1208037337  484 VKVPI 488
Cdd:cd11278    487 TKIPL 491
TIG_plexin pfam17960
TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and ...
 549-636 7.40e-27

TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and Transcription factors) found in plexins.


Pssm-ID: 465588  Cd Length: 89  Bit Score: 105.81  E-value: 7.40e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  549 TPANISREEKRNIFLAISDLPSLreEEFYSCYFEDY-ESPAVLTESGIMCPSPDPSQAPALPTGTDHVTIKLVVRF--HD 625
Cdd:pfam17960    1 TPDNISRTTATQLTLTVPNLPAL--SEGYSCVFGDLtESPATVHDNGVKCATPPPSQLPPIPTGQDHVTVKLSLRSseTG 78

                           90
                   ....*....|.
gi 1208037337  626 IFIASVDFSFY 636
Cdd:pfam17960   79 VDFASTNFTFY 89
Sema pfam01403
Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and ...
 286-469 1.26e-25

Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and Swiss:P51805


Pssm-ID: 460197 [Multi-domain]  Cd Length: 180  Bit Score: 105.82  E-value: 1.26e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  286 LQAAYVTRPGKELAQGqldtegEVLFAAFSAWQASSgklSEESALCVYTMEEVDRLTNwTRDVCYMRDGkSEEGTEVAYI 365
Cdd:pfam01403    1 LQDVFVLKPGAGDALD------TVLYGVFTTQWSNS---IGGSAVCAFSLSDINAVFE-GPFKEQEKSD-SKWLPYTGKV 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  366 EYDVSSNCV------QLPADTLyaypCGSDHTPSPMASRVPLEAAPLLEKTEARLTAVAVN---VEDG-HTIAFLGDSRG 435
Cdd:pfam01403   70 PYPRPGTCIndplrlDLPDSVL----NFVKDHPLMDEAVQPVGGRPLLVRTGVRLTSIAVDrvqALDGnYTVLFLGTDDG 145

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 1208037337  436 RLHKVYLGAQGEAHTYASVSI-QVNSMVSGDLLFD 469
Cdd:pfam01403  146 RLHKVVLVGSEESHIIEEIQVfPEPQPVLNLLLSS 180
TIG_2 pfam18020
TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG ...
 992-1091 2.95e-23

TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG domains have an Ig-like fold.


Pssm-ID: 465619  Cd Length: 94  Bit Score: 95.81  E-value: 2.95e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  992 GSSLFPVNVARKITLLGKNFHLYQDQQWDYECVLNLEGRTVVMEAYVEGEETnkslcyITCQMNQYSYAAPQLEFSAMVF 1071
Cdd:pfam18020    1 GSILVPVGVEREITLKARNLPLFQSGQLGYECVFEIEGATHVVPASRESSDS------ITCQEHQFSYSGSSGELPATFY 74

                           90       100
                   ....*....|....*....|
gi 1208037337 1072 VQRRRHLRVDSAADLHVTFY 1091
Cdd:pfam18020   75 VTWNGGHRLDNPANLQVVLY 94
IPT_plexin_repeat3 cd01181
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1321-1443 2.12e-19

Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238586  Cd Length: 99  Bit Score: 85.16  E-value: 2.12e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1321 PNITFAEPPKSFLSGGRVLRVHGYNLDVVQKPKIRVTVspserrrrgvgrwrriipdsecpedslcsIQQFEEPCLINSS 1400
Cdd:cd01181      1 PTITRIEPEWSFLSGGTPITVTGTNLNTVQEPRIRVKY-----------------------------GGVEKTSCKVRNS 51

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1208037337 1401 YLILCKTPAINLLLRS---VRIKLEFILDNLSF-DFNSLHPMPFSYE 1443
Cdd:cd01181     52 TLMTCPAPSLALLNRSpepGERPVEFGLDGDNVqSLLILNRTSFSYY 98
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1231-1318 5.76e-17

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 77.65  E-value: 5.76e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1231 PELKSIVPTQGPKAGGTCLTLLGSKLLTGhpNEISVLLGDLPCQILSEmTEDQLACQTSPSNVSTELPVTIKYGeQERRL 1310
Cdd:cd01179      1 PSITSLSPSYGPQSGGTRLTITGKHLNAG--SSVRVTVGGQPCKILSV-SSSQIVCLTPPSASPGEAPVKVLID-GARRL 76


                   ....*...
gi 1208037337 1311 EGSLFRYT 1318
Cdd:cd01179     77 APLVFTYT 84
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1139-1229 1.57e-15

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 73.64  E-value: 1.57e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1139 PLIHSVYPLSGPVEGGTRITITGSNLGQkhQDIAETVTVAGIPCAVdaqEYEISSSIVCITGGSWTERFGHIVVEV---P 1215
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGS--GSPRVRVTVGGVPCKV---LNVSSTEIVCRTPAAATPGEGPVEVTVdgaN 75

                           90
                   ....*....|....
gi 1208037337 1216 GGGRGVSGHVFTYQ 1229
Cdd:cd00603     76 VSARVLSNTTFTYV 89
Sema_RON cd11279
The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase; RON receptor ...
 42-488 6.86e-15

The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase; RON receptor tyrosine kinase is a Macrophage-stimulating protein (MSP) receptor. Upon binding of MSP, RON is activated via autophosphorylation within its kinase catalytic domain, resulting in a wide range of effects, including proliferation, tubular morphogenesis, angiogenesis, cellular motility and invasiveness. By interacting with downstream signaling molecules, it regulates macrophage migration, phagocytosis, and nitric oxide production. RON has been implicated in cancers of the breast, colon, pancreas and ovaries because both splice variants and receptor overexpression have been identified in these tumors. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as ligand recognition and binding model. RON is composed of an alpha-beta heterodimer. The extracellular alpha chain is disulfide linked to the beta chain, which contains an extracellular ligand-binding region with a Sema domain, a PSI domain and four IPT repeats, a transmembrane segment, and an intracellular catalytic tyrosine kinase domain. The Sema domain of RON may be necessary for receptor dimerization and activation.


Pssm-ID: 200540 [Multi-domain]  Cd Length: 493  Bit Score: 79.82  E-value: 6.86e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337   42 ESGTIYLGATNFLFQLTSDL-LLENMVqTGPVlDSKDClppVSKLECPQAHH----TDNHNKLLLVNTVQKELIVCGSVH 116
Cdd:cd11279     37 DASAVFVATRNHLHVLNPELkLLQNLV-TGPT-GSPGC---QICALCPPGPPgpspEDTDNKVLVLDPEEPWLYSCGSSL 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  117 QGICEKRSLA---SIDHV-----LFRPE--SPGD-TQYVAAndPNITTVGLIAYSKdeVPLLFVGRGYTSRgVGGGIPP- 184
Cdd:cd11279    112 HGRCFLHELEsrgSAVHIastacLFSANanKPSDcPDCVAS--PLGTRVTVVEQSH--TSYFYVASTLNSS-VAASYSPr 186

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  185 -ITTRNLRahgGDVQATDS--HSIFSYEEtaklavgRLSEYNHHFIKSFTYHSSVYFLFYRRDlKSQSREYKTYISRICL 261
Cdd:cd11279    187 sVSIRRLK---SDQDGFAPgfHSLTVLPK-------YLDSYPIHYVHSFTSGDFVYFLTVQPE-SPDSSAYHTRLVRLSA 255

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  262 DDSHYYSYVELPLLCQ------------SKANTYSLLQAAYVTRPGKELAqGQLDTEG--EVLFAAFSAWQASSGKLSEE 327
Cdd:cd11279    256 KEPELRDYRELVLDCRfepkrrrrrrpaEREVPYNVLQAAHAAPVGSKLA-VELGISEgqEVLFGVFAESQPGSPVPQKN 334

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  328 SALCVYTMEEVDRLTNWTRDVCYmrDGKSEEGTEVAYIEYDVSSNCVQLPAdtlyaypcGSDHTPSPMASRVPLEAAPLL 407
Cdd:cd11279    335 SAVCAFPISLLNEAIDEGMEKCC--SSSNSDRLFRGLDFFQPQSYCPHPPN--------LSAAVSNTSCWNFPTLVSTSS 404

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  408 EKTE--------ARLTAVAVNVEDGHTIAFLGDSRGRLHKVYLGAQGEAHTYAS-VSIQVNSMVSGDllFDQLQEHLFVM 478
Cdd:cd11279    405 FRVDlfnghlsgVLLTSIYVTVLDNVTVAHLGTSDGRILQVVLQRSLNYLLYVSnFSLGDGQPVQRD--VSRLGDSLLFA 482

                          490
                   ....*....|
gi 1208037337  479 TQSMVVKVPI 488
Cdd:cd11279    483 SGNQVFKVNI 492
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1139-1228 4.89e-14

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 69.40  E-value: 4.89e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1139 PLIHSVYPLSGPVEGGTRITITGSNLGQKHQDIaeTVTVAGIPCAVDAQeyeISSSIVCITGGSWTERFGhIVVEVPGGG 1218
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDL--KVTIGGTPCTVISV---SSTTIVCTTPPGTSGLVN-VSVTVGGGG 74

                           90
                   ....*....|
gi 1208037337 1219 RGVSGHVFTY 1228
Cdd:pfam01833   75 ISSSPLTFTY 84
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 491-540 4.90e-14

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 68.12  E-value: 4.90e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1208037337  491 CSLYLDCESCLALKDPYCGWCVLQGRCSRRSECLRSRlSEQWLWSFNSTQ 540
Cdd:pfam01437    2 CSQYTSCSSCLAARDPYCGWCSSEGRCVRRSACGAPE-GNCEEWEQASSK 50
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1139-1228 3.32e-13

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 67.10  E-value: 3.32e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1139 PLIHSVYPLSGPVEGGTRITITGSNLGqKHQDIaeTVTV-AGIPCAVdaqEYEISSSIVCITGGSWTERFG--HIVVEVP 1215
Cdd:cd00102      1 PVITSISPSSGPVSGGTEVTITGSNFG-SGSNL--RVTFgGGVPCSV---LSVSSTAIVCTTPPYANPGPGpvEVTVDRG 74

                           90
                   ....*....|...
gi 1208037337 1216 GGGRGVSGHVFTY 1228
Cdd:cd00102     75 NGGITSSPLTFTY 87
IPT smart00429
ig-like, plexins, transcription factors;
1139-1228 9.14e-13

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 65.90  E-value: 9.14e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  1139 PLIHSVYPLSGPVEGGTRITITGSNLGqKHQDIAETVTVAGIPCAVDAQEyeiSSSIVCITGGSWTERFGHIVVEVPGGG 1218
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLK-SISVVFVEVGVGEAPCTFSPSS---STAIVCKTPPYHNIPGSVPVRTVGLRN 77

                            90
                    ....*....|..
gi 1208037337  1219 RGVSG--HVFTY 1228
Cdd:smart00429   78 GGVPSspQPFTY 89
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 686-1005 1.21e-12

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 73.07  E-value: 1.21e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  686 AQIPTSivyPSSAAPLTKSSTTaPTTAPKPVTTPVHVGPSTVPHTEAiHVTPSAAPEPTTEPT--QSPGYTHLTLSTEAA 763
Cdd:pfam17823  112 SRALAA---AASSSPSSAAQSL-PAAIAALPSEAFSAPRAAACRANA-SAAPRAAIAAASAPHaaSPAPRTAASSTTAAS 186

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  764 SLQAATEAPLPPPADKPAVTVPET-TSPAASVLSSPSKNMDHIALPTEGPA--TAQDAWHTDPPTTLGGSPLHTSPVAAV 840
Cdd:pfam17823  187 STTAASSAPTTAASSAPATLTPARgISTAATATGHPAAGTALAAVGNSSPAagTVTAAVGTVTPAALATLAAAAGTVASA 266

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  841 -----TPSPQVTsfkwSPSPFPTTEALTSAIS-SPQMASQVPGSPV-VSDDAPGLPGTElpvsrLPTSAPPQWLLEKGTE 913
Cdd:pfam17823  267 agtinMGDPHAR----RLSPAKHMPSDTMARNpAAPMGAQAQGPIIqVSTDQPVHNTAG-----EPTPSPSNTTLEPNTP 337

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  914 lqdtedwmdllQAENDTSLFSASTLLSGDGDSSERDVPDFPRILHPDLdyqydapefweESEEPSWGPNACPCVEGIQGS 993
Cdd:pfam17823  338 -----------KSVASTNLAVVTTTKAQAKEPSASPVPVLHTSMIPEV-----------EATSPTTQPSPLLPTQGAAGP 395

                          330
                   ....*....|....
gi 1208037337  994 S--LFPVNVARKIT 1005
Cdd:pfam17823  396 GilLAPEQVATEAT 409
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
490-527 4.55e-12

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 62.56  E-value: 4.55e-12
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1208037337   490 ECSLYLDCESCLALKDPYCGWCVLQGRCSRRSECLRSR 527
Cdd:smart00423    1 RCSKYTSCSECLLARDPYCAWCSSQGRCTSGERCDSRR 38
Sema_semaphorin cd11235
The Sema domain, a protein interacting module, of semaphorins; Semaphorins are regulator ...
 32-487 7.61e-12

The Sema domain, a protein interacting module, of semaphorins; Semaphorins are regulator molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. They can be divided into 7 classes. Vertebrates have members in classes 3-7, whereas classes 1 and 2 are known only in invertebrates. Class 2 and 3 semaphorins are secreted proteins; classes 1 and 4 through 6 are transmembrane proteins; and class 7 is membrane associated via glycosylphosphatidylinositol (GPI) linkage. The semaphorins exert their function through their receptors, the neuropilin and plexin families. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200496 [Multi-domain]  Cd Length: 437  Bit Score: 70.13  E-value: 7.61e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337   32 TKFLHLSMDSESGTIYLGATN--FLFQLTSDL-LLENMVQTGPvlDSKD-C-LPPVSKLECpqahhtDNHNKLLLVNTvQ 106
Cdd:cd11235      1 LKYHTKLLHEDRSTLYVGARDrvYLVDLDSLYtEQKVAWPSSP--DDVDtCyLKGKSKDDC------RNFIKVLEKNS-D 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  107 KELIVCGS-VHQGICEKRSLASIDHVlfrpESPGDTQYVAANDPNITTVGLiaYSKDEvplLFVGrgyTSRGVGGGIPPI 185
Cdd:cd11235     72 DSLLVCGTnAFNPSCRNYNVETFELV----GKEESGRGKCPYDPDHNSTAL--FADGE---LYSG---TSADFLGTDPVI 139

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  186 TtRNLRAHGGdvQATDSHSIFSYEETaklavgrlseynhHFIKSFTYHSSVYFlFYRRDlksqSREYKTY-------ISR 258
Cdd:cd11235    140 Y-RTLGHNPP--LRTEYHDSKWLNEP-------------QFVGAFDIGDYVYF-FFREI----AVEYINCgkavysrVAR 198

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  259 ICLDD--------SHYYSYVELPLLCQSKANT---YSLLQAAYVTrPGKELAQGqldtegeVLFAAFS-AWQASSGklse 326
Cdd:cd11235    199 VCKNDqggsrsleKKWTTFLKARLNCSVPGEFpfyFNELQDVFDL-PSPSNKEK-------IFYAVFTtPYNSIPG---- 266

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  327 eSALCVYTMEEVDR------------LTNWTRDVCYMRDGKSEEGTevayieYDVSSNcvqLPADTLyayPCGSDHTpsP 394
Cdd:cd11235    267 -SAVCAYSLSDIEAvfngpfkeqhssNSAWLPVPDERVPEPRPGTC------VDDSSP---LPDDTL---NFIKSHP--L 331

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  395 MASRV-PLEAAPLLEKTEA--RLTAVAVNVEDG-----HTIAFLGDSRGRLHKVYlgAQGEAHTYASVSIQV------NS 460
Cdd:cd11235    332 MDEAVtPILNRPLFIKTDVnyRFTKIAVDRVQAklgqtYDVLFVGTDRGIILKVV--SLPEQGLQASNILEEmpvgppPE 409

                          490       500
                   ....*....|....*....|....*..
gi 1208037337  461 MVSGdLLFDQLQEHLFVMTQSMVVKVP 487
Cdd:cd11235    410 PIQT-MQLSRKRRSLYVGSETGVLQVP 435
PHA03247 PHA03247
large tegument protein UL36; Provisional
 687-905 1.47e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 70.35  E-value: 1.47e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  687 QIPTSIVYPSSAAPLTKSST-----TAPTTAPKPVTTPVHVGPSTVPHTEAIHVTPSA-APEPTTEPTQSPGYthltlST 760
Cdd:PHA03247  2681 QRPRRRAARPTVGSLTSLADpppppPTPEPAPHALVSATPLPPGPAAARQASPALPAApAPPAVPAGPATPGG-----PA 2755

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  761 EAASLQAATEAPLP-PPADKPAVTVPETTSPAASVLSSPSKNMDHIALPTEGPATAQDAWHTDPPTTLGGSPLHTSPVAA 839
Cdd:PHA03247  2756 RPARPPTTAGPPAPaPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQ 2835

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1208037337  840 VTPSPQvtsfkwSPSPFPTTEALTSAIsspqmasqVPGSPVV----SDDAPGLPGT--ELPVSRLPTSAPPQ 905
Cdd:PHA03247  2836 PTAPPP------PPGPPPPSLPLGGSV--------APGGDVRrrppSRSPAAKPAApaRPPVRRLARPAVSR 2893
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1231-1318 4.95e-11

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 60.93  E-value: 4.95e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1231 PELKSIVPTQGPKAGGTCLTLLGSKLLTGHPNeISVLLGDLPCQILSEmTEDQLACQTSPSNVSTELPVTIKYGE---QE 1307
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPR-VRVTVGGVPCKVLNV-SSTEIVCRTPAAATPGEGPVEVTVDGanvSA 78

                           90
                   ....*....|.
gi 1208037337 1308 RRLEGSLFRYT 1318
Cdd:cd00603     79 RVLSNTTFTYV 89
PHA03247 PHA03247
large tegument protein UL36; Provisional
 683-985 6.18e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 68.43  E-value: 6.18e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  683 NERAQIPTSIVYPSSAAPLTKSSTTAPTTAPKPVTTPVHVGPST-VPHTEAIHVTPSAAPEPTTEPTQSPGYTHLTLSTE 761
Cdd:PHA03247  2755 ARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLpSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSA 2834

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  762 AASLQAATEAPLPP-----------------PADKPAVTVPETTS-PAASVLSSP--SKNMDHIALPTEGPATAQDAWHT 821
Cdd:PHA03247  2835 QPTAPPPPPGPPPPslplggsvapggdvrrrPPSRSPAAKPAAPArPPVRRLARPavSRSTESFALPPDQPERPPQPQAP 2914

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  822 DPPTTLGGSPLHTSPVAAVTPSPQVTSfkwSPSPFPTTEAL---TSAISSPQMASQVPGS-PVVSDDAPG-LPGTELPVS 896
Cdd:PHA03247  2915 PPPQPQPQPPPPPQPQPPPPPPPRPQP---PLAPTTDPAGAgepSGAVPQPWLGALVPGRvAVPRFRVPQpAPSREAPAS 2991

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  897 ------RLPTSAPPQWLLEKGTELQDTEDWMDLLQA---ENDTSLFSASTLLSGDGDSSERDVPDfprilhPDLDYQYDA 967
Cdd:PHA03247  2992 stppltGHSLSRVSSWASSLALHEETDPPPVSLKQTlwpPDDTEDSDADSLFDSDSERSDLEALD------PLPPEPHDP 3065

                          330
                   ....*....|....*...
gi 1208037337  968 PEFWEESEEPSWGPNACP 985
Cdd:PHA03247  3066 FAHEPDPATPEAGARESP 3083
PHA03247 PHA03247
large tegument protein UL36; Provisional
 685-905 2.07e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 66.89  E-value: 2.07e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  685 RAQIPTsiVYPSSAAPLTK-------SSTTAPTTAPKPVTTPVHVGPSTVPH-TEAIHVTPSAAPEPtTEPTQSPGYTHL 756
Cdd:PHA03247  2585 RARRPD--APPQSARPRAPvddrgdpRGPAPPSPLPPDTHAPDPPPPSPSPAaNEPDPHPPPTVPPP-ERPRDDPAPGRV 2661

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  757 TLSTEAASLQAATEAPLPP-----PADKPAV-------------------------TVPETTSPAASVLSSPSKNMDHIA 806
Cdd:PHA03247  2662 SRPRRARRLGRAAQASSPPqrprrRAARPTVgsltsladpppppptpepaphalvsATPLPPGPAAARQASPALPAAPAP 2741

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  807 LPT-EGPAT-AQDAWHTDPPTTlGGSPLHTSPVAAVTPSPQVTSFKWSPSPFPTTEALTSAISSPQMASQVPGS----PV 880
Cdd:PHA03247  2742 PAVpAGPATpGGPARPARPPTT-AGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPaaalPP 2820

                          250       260
                   ....*....|....*....|....*..
gi 1208037337  881 VSDDAPGL--PGTELPVSRLPTSAPPQ 905
Cdd:PHA03247  2821 AASPAGPLppPTSAQPTAPPPPPGPPP 2847
PHA03247 PHA03247
large tegument protein UL36; Provisional
 695-905 1.35e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 64.19  E-value: 1.35e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  695 PSSAAPLTKSSTTAPTTAPKPVTTPVHVGPSTVPHTEAIHVTPSAAPEPTTEP---TQSPGYTHLTLSTEAASLQAATEA 771
Cdd:PHA03247  2734 ALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPavaSLSESRESLPSPWDPADPPAAVLA 2813

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  772 PLP--PPADKPAVTVPETTSPAASVLSSPSKNMDHiALPTEGPATAQDAWHTDPPTtlgGSPlhtSPVAAVTPSPQVTSF 849
Cdd:PHA03247  2814 PAAalPPAASPAGPLPPPTSAQPTAPPPPPGPPPP-SLPLGGSVAPGGDVRRRPPS---RSP---AAKPAAPARPPVRRL 2886

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1208037337  850 KwSPSPFPTTEALTSAISSPQMASQvPGSPvvsddAPGLPGTELPVSRLPTSAPPQ 905
Cdd:PHA03247  2887 A-RPAVSRSTESFALPPDQPERPPQ-PQAP-----PPPQPQPQPPPPPQPQPPPPP 2935
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 683-873 3.77e-09

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 62.24  E-value: 3.77e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  683 NERAQIPTSIVYPSSaapLTKSSTTAPTTAPKPVTTPVHVGPStvphTEAIHVTPSAAPEPTTEPTQSPGYTHLTlstea 762
Cdd:pfam05109  443 NTTTGLPSSTHVPTN---LTAPASTGPTVSTADVTSPTPAGTT----SGASPVTPSPSPRDNGTESKAPDMTSPT----- 510

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  763 aslqAATEAPLP-PPADKPAVT--VPETTSPAASVLSSPSKnmdhIALPTEGPATAQDAWHTDPPTTLGGSPLHTSPVAA 839
Cdd:pfam05109  511 ----SAVTTPTPnATSPTPAVTtpTPNATSPTLGKTSPTSA----VTTPTPNATSPTPAVTTPTPNATIPTLGKTSPTSA 582

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 1208037337  840 V-TPSPQVTS---FKWSPSPFPTTEALTSAISSPQMAS 873
Cdd:pfam05109  583 VtTPTPNATSptvGETSPQANTTNHTLGGTSSTPVVTS 620
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 676-904 3.90e-09

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 62.09  E-value: 3.90e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  676 EEGVIIYNERAQIPTSIVYPSSAAPLTKSSTTAPTTAP------KPVTTPVHVGPSTVPH---TEAIHVTPSAAPE--PT 744
Cdd:pfam03154  232 QQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPslhgqmPPMPHSLQTGPSHMQHpvpPQPFPLTPQSSQSqvPP 311

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  745 TEPTQSPGYTHLTLST-----EAASLQAATEAPLPP-----PADKPAVTVPETTSPAASVLSSPSknmdHIAlpteGPAT 814
Cdd:pfam03154  312 GPSPAAPGQSQQRIHTppsqsQLQSQQPPREQPLPPaplsmPHIKPPPTTPIPQLPNPQSHKHPP----HLS----GPSP 383

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  815 AQDAWHTDPPTT---LGGSPLHTSPVAAVTPSPQVTSFKWSPSPFPTTEALTSAISSPQMASQVPGS----PVVSDD--- 884
Cdd:pfam03154  384 FQMNSNLPPPPAlkpLSSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTsglhQVPSQSpfp 463

                          250       260
                   ....*....|....*....|....
gi 1208037337  885 ----APGLPGTELPVSRLPTSAPP 904
Cdd:pfam03154  464 qhpfVPGGPPPITPPSGPPTSTSS 487
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
704-923 6.57e-09

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 61.05  E-value: 6.57e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  704 SSTTAPTTAPKPVTTPVHVGPSTVPHTEAIHVTPSAAPEPTTEPTQSPGYTHLTLSTEAASLQAATEAPL-------PPP 776
Cdd:PRK12323   372 AGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASArgpggapAPA 451

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  777 ADKPAVTVPETTSPAASVLSSPskNMDHIALPTEGPATAQDAWHTDPPttlggsPLHTSPVAAVTPSPQVTSFKWSPSPF 856
Cdd:PRK12323   452 PAPAAAPAAAARPAAAGPRPVA--AAAAAAPARAAPAAAPAPADDDPP------PWEELPPEFASPAPAQPDAAPAGWVA 523

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1208037337  857 PTTEALTSAISSPQMASQVPGSPvvsddAPGLPGTELPVSRLPTSAPPQwLLEKGTELQDTEDWMDL 923
Cdd:PRK12323   524 ESIPDPATADPDDAFETLAPAPA-----AAPAPRAAAATEPVVAPRPPR-ASASGLPDMFDGDWPAL 584
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1139-1228 6.92e-09

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 54.54  E-value: 6.92e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1139 PLIHSVYPLSGPVEGGTRITITGSNLgqkhqDIAET--VTVAGIPCAVDAQEyeiSSSIVCITGGSWTERFGHIVVEVpG 1216
Cdd:cd01179      1 PSITSLSPSYGPQSGGTRLTITGKHL-----NAGSSvrVTVGGQPCKILSVS---SSQIVCLTPPSASPGEAPVKVLI-D 71

                           90
                   ....*....|..
gi 1208037337 1217 GGRGVSGHVFTY 1228
Cdd:cd01179     72 GARRLAPLVFTY 83
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1231-1318 7.58e-09

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 54.77  E-value: 7.58e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1231 PELKSIVPTQGPKAGGTCLTLLGSKLLTGhpNEISVLL-GDLPCQILSEmTEDQLACQTSPSNVSTELPV--TIKYGEQE 1307
Cdd:cd00102      1 PVITSISPSSGPVSGGTEVTITGSNFGSG--SNLRVTFgGGVPCSVLSV-SSTAIVCTTPPYANPGPGPVevTVDRGNGG 77

                           90
                   ....*....|.
gi 1208037337 1308 RRLEGSLFRYT 1318
Cdd:cd00102     78 ITSSPLTFTYV 88
RasGAP cd04519
Ras GTPase Activating Domain; RasGAP functions as an enhancer of the hydrolysis of GTP that is ...
 1985-2127 9.56e-09

Ras GTPase Activating Domain; RasGAP functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Proteins having a RasGAP domain include p120GAP, IQGAP, Rab5-activating protein 6, and Neurofibromin, among others. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP exhibit no similarity at their amino acid sequence level. RasGTPases function as molecular switches in a large number of signaling pathways. They are in the on state when bound to GTP, and in the off state when bound to GDP. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213328  Cd Length: 256  Bit Score: 58.66  E-value: 9.56e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1985 EIYLTRLLSMKGTLQKFVDDLFQVILSTNRPVPLAVKYFFDLLDEQAIHYGIADPETIHIWKTNSLPLRFWINIIKNPQ- 2063
Cdd:cd04519    115 LPVGEDLEENLENLLELVNKLVDRILSSLDRLPPELRYVFKILREFLAERFPEEPDEAYQAVSGFLFLRFICPAIVSPEl 194

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1208037337 2064 -FVFDVQTSDNVDAVLLVIAQTFMDSCTiadhklgRDSPINKLLYARD----IPRYKQMVERYYADIRQ 2127
Cdd:cd04519    195 fGLVPDEPSEQARRNLTLISKVLQSLAN-------GVEFGDKEPFMKPlndfIKSNKPKLKQFLDELSS 256
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1231-1317 1.76e-08

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 53.60  E-value: 1.76e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1231 PELKSIVPTQGPKAGGTCLTLLGSKLLTGHPNeISVLLGDLPCQILSeMTEDQLACQTsPSNVSTELPVTIKYGEQERRL 1310
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSD-LKVTIGGTPCTVIS-VSSTTIVCTT-PPGTSGLVNVSVTVGGGGISS 77


                   ....*..
gi 1208037337 1311 EGSLFRY 1317
Cdd:pfam01833   78 SPLTFTY 84
Sema_4 cd11240
The Sema domain, a protein interacting module, of class 4 semaphorins (Sema4); Class 4 ...
 236-488 2.35e-08

The Sema domain, a protein interacting module, of class 4 semaphorins (Sema4); Class 4 semaphorins (Sema4s) are transmembrane regulator molecules involved in the development of the nervous system, immune response, cytoskeletal organization, angiogenesis, and cell-cell interactions. There are 7 distinct subfamilies in class 4 semaphorins, named 4A to 4G. Several class 4 subfamilies play important roles in the immune system and are called "immune semaphorins". Sema4A plays critical roles in T cell-DC interactions in the immune response. Sema4D/CD100, expressed by lymphocytes, promotes the aggregation and survival of B lymphocytes and inhibits cytokine-induced migration of immune cells in vitro. It is required for normal activation of B and T lymphocytes. Sema4B negatively regulates basophil functions through T cell-basophil contacts and significantly inhibits IL-4 and IL-6 production from basophils in response to various stimuli, including IL-3 and papain. Sema4s not only influence the activation state of cells but also modulate their migration and survival. The effects of Sema4s on nonlymphoid cells are mediated by plexin D1 and plexin Bs. The Sema4G and Sema4C genes are expressed in the developing cerebellar cortex and are involved in neural tube closure and development of cerebellar granules cells through receptor plexin B2. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200501 [Multi-domain]  Cd Length: 456  Bit Score: 58.96  E-value: 2.35e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  236 VYFLFYRRdlksqSREYKTY-------ISRICLDD--------SHYYSYVELPLLCQSKANT--YSLLQAAYVTRPGkel 298
Cdd:cd11240    193 IYFFFTET-----AVEYDFYekvtvsrVARVCKGDlggqrtlqKKWTTFLKAQLVCSQPDSGlpFNVLRDVFVLSPD--- 264

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  299 aqgqlDTEGEVLFAAFSA-WQASSGklseeSALCVYTMEEVDRL------------TNWTR---DVCYMRDGKSeeGTEV 362
Cdd:cd11240    265 -----SWDATIFYGVFTSqWNVSGL-----SAVCAYSLEDIKKVfsgkykefnretSKWSRytgPVPDPRPGAC--ITNS 332

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  363 AYIEYDVSSncVQLPADTLYAYpcgSDHtpsP-MASRVPLEAAPLLEKTEARLTAVAVNVEDG-----HTIAFLGDSRGR 436
Cdd:cd11240    333 ARSQGITSS--LNLPDNVLTFV---KDH---PlMDEQVHPINRPLLVKSGVNYTRIAVHRVQAldgqtYTVLFLGTEDGF 404

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1208037337  437 LHKVYLGAqGEAHTYASVSIQVNSMVSGDLLFDQLQEHLFVMTQSMVVKVPI 488
Cdd:cd11240    405 LHKAVSLD-GGMHIIEEIQLFDQPQPVKNLLLSSSKGVLYVGSSSGVVQVPL 455
IPT smart00429
ig-like, plexins, transcription factors;
1320-1442 6.99e-08

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 52.04  E-value: 6.99e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  1320 DPNITFAEPPKSFLSGGRVLRVHGYNLDVVQKPKIRVTVSPSErrrrgvgrwrriipdsecpedslCSIQQfeepcliNS 1399
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGEAP-----------------------CTFSP-------SS 50

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....
gi 1208037337  1400 SYLILCKTPAINLLLRSVRI-KLEFILDNLSFDfnslhPMPFSY 1442
Cdd:smart00429   51 STAIVCKTPPYHNIPGSVPVrTVGLRNGGVPSS-----PQPFTY 89
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 685-905 7.53e-08

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 57.66  E-value: 7.53e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  685 RAQIPTSIVYPSSAAPLTKSSTT-----APTTAPKPVTTPVHVGPSTVPHTEAIHVTPSAAPEPTTEPTQSPGYTHLTLS 759
Cdd:pfam17823  146 RAAACRANASAAPRAAIAAASAPhaaspAPRTAASSTTAASSTTAASSAPTTAASSAPATLTPARGISTAATATGHPAAG 225

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  760 TEAASLQAATEAPLPPPADKPAVT---VPETTSPAASVLSS-PSKNMDHIALPTEGPATaqdawHTdPPTTLGGSPLHTS 835
Cdd:pfam17823  226 TALAAVGNSSPAAGTVTAAVGTVTpaaLATLAAAAGTVASAaGTINMGDPHARRLSPAK-----HM-PSDTMARNPAAPM 299

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1208037337  836 PVAAVTPSPQVTS----FKWSPSPFPTTEALTSAISSPQMASQVPGSPVVSDDAPGLPGTELPVSRLPTSAPPQ 905
Cdd:pfam17823  300 GAQAQGPIIQVSTdqpvHNTAGEPTPSPSNTTLEPNTPKSVASTNLAVVTTTKAQAKEPSASPVPVLHTSMIPE 373
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 687-915 1.11e-07

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 57.47  E-value: 1.11e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  687 QIPTSIVYPSSAAPltKSSTTAPTTAPKPVTTPVHVGPStvPHTEAIHVTPSAAPEPTTEPTQSPGYTHLTLSTEAASLQ 766
Cdd:pfam03154  175 QAQSGAASPPSPPP--PGTTQAATAGPTPSAPSVPPQGS--PATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQ 250

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  767 AATeaPLPPPADKPAVTVPETT-----SPAASVLSSPSKNMDHIALPTEGPATAQDAWHTDPPTTLGGSP------LHTS 835
Cdd:pfam03154  251 PMT--QPPPPSQVSPQPLPQPSlhgqmPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPgqsqqrIHTP 328

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  836 PVAAVTPSPQ-------------VTSFKWSPS------PFPTTEALTSAISSP---QMASQVPGSPVVSddapglPGTEL 893
Cdd:pfam03154  329 PSQSQLQSQQppreqplppaplsMPHIKPPPTtpipqlPNPQSHKHPPHLSGPspfQMNSNLPPPPALK------PLSSL 402

                          250       260
                   ....*....|....*....|...
gi 1208037337  894 PVSRLPTSAPPQW-LLEKGTELQ 915
Cdd:pfam03154  403 STHHPPSAHPPPLqLMPQSQQLP 425
IPT smart00429
ig-like, plexins, transcription factors;
1230-1318 1.91e-07

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 50.88  E-value: 1.91e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  1230 NPELKSIVPTQGPKAGGTCLTLLGSKLLTGHPNEISVLLGDLPCQILSEmTEDQLACQTSPSNVST-ELPV-TIKYGEQE 1307
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGEAPCTFSPS-SSTAIVCKTPPYHNIPgSVPVrTVGLRNGG 79

                            90
                    ....*....|.
gi 1208037337  1308 RRLEGSLFRYT 1318
Cdd:smart00429   80 VPSSPQPFTYV 90
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 701-903 6.21e-07

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 54.92  E-value: 6.21e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  701 LTKSSTTAPTTAPKPVTTPvhvGPSTVPHTEAIHVTPSAAPEPTTeptQSPGYTHLTLSTEAAslqaATEAPLPPPADKP 780
Cdd:pfam05109  405 ITRTATNATTTTHKVIFSK---APESTTTSPTLNTTGFAAPNTTT---GLPSSTHVPTNLTAP----ASTGPTVSTADVT 474

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  781 AVTVPETTSPAASVLSSPSknmdhialPTEGPATAQdawhtdppttlggSPLHTSPVAAVT-PSPQVTSfkwsPSPFPTT 859
Cdd:pfam05109  475 SPTPAGTTSGASPVTPSPS--------PRDNGTESK-------------APDMTSPTSAVTtPTPNATS----PTPAVTT 529

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 1208037337  860 EalTSAISSPQMASQVPGSPVVSDDapglPGTELPVSRLPTSAP 903
Cdd:pfam05109  530 P--TPNATSPTLGKTSPTSAVTTPT----PNATSPTPAVTTPTP 567
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 693-904 6.24e-07

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 54.55  E-value: 6.24e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  693 VYPSSAAPLTKSSTTAPTTAPKPvtTPVHVGPSTVPHTEAIhvtpSAAPEPTTEPtqSPGYTHLTLSTEAASLQAATEAP 772
Cdd:PLN03209   366 VVPRPLSPYTAYEDLKPPTSPIP--TPPSSSPASSKSVDAV----AKPAEPDVVP--SPGSASNVPEVEPAQVEAKKTRP 437

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  773 LPPPADKPAVTVPETTSPAASVLSSPSKNMDHIALPTEGPATAQDAWHTDPPTTLGGSPLHTSPVAA---VTPSPQVTSF 849
Cdd:PLN03209   438 LSPYARYEDLKPPTSPSPTAPTGVSPSVSSTSSVPAVPDTAPATAATDAAAPPPANMRPLSPYAVYDdlkPPTSPSPAAP 517

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1208037337  850 KWSPSPFPTTEALTSAISSPQMASQVPGSPVVSDDAPGLPGTELPVSRLPTSAPP 904
Cdd:PLN03209   518 VGKVAPSSTNEVVKVGNSAPPTALADEQHHAQPKPRPLSPYTMYEDLKPPTSPTP 572
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
696-904 1.03e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 54.09  E-value: 1.03e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  696 SSAAPLTKSSTTAPTTAPKPvtTPVHVGPSTVPHTEAIHVTPSAAPEPTTEPTQSPGYTHLTLSTEAASLQAATEAPLPP 775
Cdd:PRK07003   393 ASAVPAVTAVTGAAGAALAP--KAAAAAAATRAEAPPAAPAPPATADRGDDAADGDAPVPAKANARASADSRCDERDAQP 470

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  776 PADKPAVTVPETTSPAAsVLSSPSknmdhialPTEGPATAQDAWHTDPPTTLGGSPLHTSPVAAVTPSPQvtsfkwSPSP 855
Cdd:PRK07003   471 PADSGSASAPASDAPPD-AAFEPA--------PRAAAPSAATPAAVPDARAPAAASREDAPAAAAPPAPE------ARPP 535

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1208037337  856 FPTTEALTSAISSPQMASQV---PGSPVVSDDAPGLPGTELPVSRLPTSAPP 904
Cdd:PRK07003   536 TPAAAAPAARAGGAAAALDVlrnAGMRVSSDRGARAAAAAKPAAAPAAAPKP 587
PHA03269 PHA03269
envelope glycoprotein C; Provisional
 680-806 1.29e-06

envelope glycoprotein C; Provisional


Pssm-ID: 165527 [Multi-domain]  Cd Length: 566  Bit Score: 53.58  E-value: 1.29e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  680 IIYNERAQIPTSIVYPSSAAPLTK---SSTTAPTTAPKPVTTPVHVG-----PSTVPhTEAIHVTPSAAPEPTTEPTQSP 751
Cdd:PHA03269    18 IIANLNTNIPIPELHTSAATQKPDpapAPHQAASRAPDPAVAPTSAAsrkpdLAQAP-TPAASEKFDPAPAPHQAASRAP 96

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1208037337  752 GYTHLTLSTEAASLQAA---TEAPL--PPPADKPAVTVPETTSPAASVLSSP-----SKNMDHIA 806
Cdd:PHA03269    97 DPAVAPQLAAAPKPDAAeafTSAAQahEAPADAGTSAASKKPDPAAHTQHSPppfayTRSMEHIA 161
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
689-906 1.35e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 53.70  E-value: 1.35e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  689 PTSIVYPSSAAPLTKSSTTAPTTAPKPVT-----TPVHVGPSTVPHTEAIHVTPSAAP-EPTTEPTQSPgythltlstea 762
Cdd:PRK07003   406 AGAALAPKAAAAAAATRAEAPPAAPAPPAtadrgDDAADGDAPVPAKANARASADSRCdERDAQPPADS----------- 474

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  763 aSLQAATEAPLPPPADK----PAVTVPETTSPAASVLSSPSKnmdhIALPTEGPATAQDAWHTDPPTTLGGSPLHTSPVA 838
Cdd:PRK07003   475 -GSASAPASDAPPDAAFepapRAAAPSAATPAAVPDARAPAA----ASREDAPAAAAPPAPEARPPTPAAAAPAARAGGA 549

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  839 AV------TPSPQVTSFKWSPSPFPTTEALTSAISSPQMASQV------PGSPVVSDDAPGLPGTELPVSRLPTSAPPQW 906
Cdd:PRK07003   550 AAaldvlrNAGMRVSSDRGARAAAAAKPAAAPAAAPKPAAPRVavqvptPRARAATGDAPPNGAARAEQAAESRGAPPPW 629
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 687-904 1.83e-06

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 53.38  E-value: 1.83e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  687 QIPTSIVYPSSAAPL---------TKSSTTA------PTTAPKPVTTPVHVGPSTVPHTEAIHVTPSA-APEP-TTEPTq 749
Cdd:pfam05109  453 HVPTNLTAPASTGPTvstadvtspTPAGTTSgaspvtPSPSPRDNGTESKAPDMTSPTSAVTTPTPNAtSPTPaVTTPT- 531

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  750 sPGYTHLTLSTEAASLQAATEAP---LPPPA---DKPAVTVPE--TTSPAASVlSSPSKNMDHialPTEGPATAQdAWHT 821
Cdd:pfam05109  532 -PNATSPTLGKTSPTSAVTTPTPnatSPTPAvttPTPNATIPTlgKTSPTSAV-TTPTPNATS---PTVGETSPQ-ANTT 605

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  822 DppTTLGGsplhTSPVAAVTPSPQVTSFKWSPSPFPTTEALTSAIS-SPQMASQVPgSPVVSDDAPglpgTELPvsrLPT 900
Cdd:pfam05109  606 N--HTLGG----TSSTPVVTSPPKNATSAVTTGQHNITSSSTSSMSlRPSSISETL-SPSTSDNST----SHMP---LLT 671


                   ....
gi 1208037337  901 SAPP 904
Cdd:pfam05109  672 SAHP 675
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
689-894 2.33e-06

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 52.83  E-value: 2.33e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  689 PTSIVYPSSAAPLTKSSTTAPTTAPKPVTTPVHVGPSTVPHTEAiHVTPSAAPEPTTEPTQSPGYTHLTLSTEAASLQAA 768
Cdd:COG3469     17 ATAVTLLGAAATAASVTLTAATATTVVSTTGSVVVAASGSAGSG-TGTTAASSTAATSSTTSTTATATAAAAAATSTSAT 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  769 TEAPLPP-PADKPAVTVPETTSPAASVLSSPSknmdhialPTEGPATAQDAWHTDPPTTLGGSPLHTSPVAAVTPSPQVT 847
Cdd:COG3469     96 LVATSTAsGANTGTSTVTTTSTGAGSVTSTTS--------STAGSTTTSGASATSSAGSTTTTTTVSGTETATGGTTTTS 167

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 1208037337  848 SFKWSPSPfPTTEALTSAISSPQMASQVPGSPVVSDDAPGLPGTELP 894
Cdd:COG3469    168 TTTTTTSA-STTPSATTTATATTASGATTPSATTTATTTGPPTPGLP 213
PRK08691 PRK08691
DNA polymerase III subunits gamma and tau; Validated
 673-876 4.41e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236333 [Multi-domain]  Cd Length: 709  Bit Score: 52.02  E-value: 4.41e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  673 AACEEGVIIYNERAQIPTSIVYPSSAAPLTKSSTTAPTTAPKPVTTPVHVGPST-------VPHTEAIHVTP-SAAPEPT 744
Cdd:PRK08691   364 ASCDANAVIENTELQSPSAQTAEKETAAKKPQPRPEAETAQTPVQTASAAAMPSegktagpVSNQENNDVPPwEDAPDEA 443

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  745 TEPTQspgythlTLSTEAASLQAATEAPLPPP--ADKPAVTVPETTSPAASVlssPSKNmDHIALPTEGPATAQDAWHTD 822
Cdd:PRK08691   444 QTAAG-------TAQTSAKSIQTASEAETPPEnqVSKNKAADNETDAPLSEV---PSEN-PIQATPNDEAVETETFAHEA 512

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  823 P--PTTLGGSPLHTSPV---AAVTPSPQVTSFKWSPSPFPT-TEALTSAISSPQMASQVP 876
Cdd:PRK08691   513 PaePFYGYGFPDNDCPPedgAEIPPPDWEHAAPADTAGGGAdEEAEAGGIGGNNTPSAPP 572
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
735-904 6.18e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 51.77  E-value: 6.18e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  735 VTPSAAPEPTTEPTQSPGythltlSTEAASLQAATEAPLPPPADKPAVTVPETTSPAASVLSSPSKNMDHIALPTEGPAT 814
Cdd:PRK07003   375 RVAGAVPAPGARAAAAVG------ASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDAP 448

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  815 AQDAWHTDPPTTLGGSPLHTSPVAAvtpsPQVTSFKWSPSPFPTT-EALTSAISSPQMASQVPGSPVVSDDAPGLPGTEL 893
Cdd:PRK07003   449 VPAKANARASADSRCDERDAQPPAD----SGSASAPASDAPPDAAfEPAPRAAAPSAATPAAVPDARAPAAASREDAPAA 524

                          170
                   ....*....|.
gi 1208037337  894 PVSRLPTSAPP 904
Cdd:PRK07003   525 AAPPAPEARPP 535
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
698-897 6.50e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 51.39  E-value: 6.50e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  698 AAPLTKSSTTAPTTAPKP-VTTPVHVGPSTVPHTEAIHVTPSAAPEPtteptqspgythltlsteAASLQAATEAPLPPP 776
Cdd:PRK07003   366 GAPGGGVPARVAGAVPAPgARAAAAVGASAVPAVTAVTGAAGAALAP------------------KAAAAAAATRAEAPP 427

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  777 A-DKPAVTVPETTSPAASVLSSPSKNMDHIAlPTEGPATAQDAWHTDPPTTLGGSPLHTSPVAAVTPSPQVTSFKWSPSP 855
Cdd:PRK07003   428 AaPAPPATADRGDDAADGDAPVPAKANARAS-ADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAA 506

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1208037337  856 FPTTEALTSAISSPQMASQVPGSPVVsddAPGLPGTELPVSR 897
Cdd:PRK07003   507 VPDARAPAAASREDAPAAAAPPAPEA---RPPTPAAAAPAAR 545
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
695-919 7.86e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 51.03  E-value: 7.86e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  695 PSSAAPLTKSSTTAPTTAPKPVTTPVHVGPSTV-PHTEAIHVT---PSAAPEPTTEPTQSPgythltLSTEAASLQAATE 770
Cdd:PRK12323   394 AAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRsPAPEALAAArqaSARGPGGAPAPAPAP------AAAPAAAARPAAA 467

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  771 APLPPPAdkPAVTVPETTSPAASVLSSPSKNMDHIALPTEGPATAQDAWHTDPP------TTLGGSPLHTSPVAAVTPSP 844
Cdd:PRK12323   468 GPRPVAA--AAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAgwvaesIPDPATADPDDAFETLAPAP 545

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1208037337  845 qvtsfkwSPSPFPTTEALTSAISSPQMASQ-VPGSPVVSD-DAPGLpgtelpVSRLPTSAPPQWLLEKgTELQDTED 919
Cdd:PRK12323   546 -------AAAPAPRAAAATEPVVAPRPPRAsASGLPDMFDgDWPAL------AARLPVRGLAQQLARQ-SELAGVEG 608
PHA03378 PHA03378
EBNA-3B; Provisional
 678-904 8.76e-06

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 51.22  E-value: 8.76e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  678 GVIIYNERAQIPTSIVYPSSAAPLTKSSTTAPTTAPKPVTTPVHVGPstvphteaihvtPSAAPEPTTEPTQSPGythlt 757
Cdd:PHA03378   670 GHIPYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQR------------PAAATGRARPPAAAPG----- 732

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  758 lsteAASLQAATEAPLPPPADKPAVTVPETTSPAASVLSSPSKNMDHIALPTEGPATAQDAWHTDPPTTlggsPLHTSPV 837
Cdd:PHA03378   733 ----RARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAPQQRPRGAPTPQ----PPPQAGP 804

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1208037337  838 AAVTPSPQVTSFKWSPSPFPTTEALTSAISSPQMASQVPG-----SPVVSDDAPGlPGTELPVSRLPTSAPP 904
Cdd:PHA03378   805 TSMQLMPRAAPGQQGPTKQILRQLLTGGVKRGRPSLKKPAalerqAAAGPTPSPG-SGTSDKIVQAPVFYPP 875
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 728-905 1.14e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 50.92  E-value: 1.14e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  728 PHTEAIHVTPSAAPEPTTEPTQspgythltLSTEAASLQAATEAPLP-PPADKPAVTVPETTSPAASVLSSPSKNMDHIA 806
Cdd:pfam03154  172 PVLQAQSGAASPPSPPPPGTTQ--------AATAGPTPSAPSVPPQGsPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLP 243

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  807 LP-------TEGPATAQDAWHTDPPTTL------GGSPLHTSPVAAVTPSPqvtsfkwsPSPFPTTealtsaissPQMA- 872
Cdd:pfam03154  244 SPhpplqpmTQPPPPSQVSPQPLPQPSLhgqmppMPHSLQTGPSHMQHPVP--------PQPFPLT---------PQSSq 306

                          170       180       190
                   ....*....|....*....|....*....|...
gi 1208037337  873 SQVPGSPvvsddAPGLPGtelPVSRLPTSAPPQ 905
Cdd:pfam03154  307 SQVPPGP-----SPAAPG---QSQQRIHTPPSQ 331
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 695-820 1.17e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 50.48  E-value: 1.17e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  695 PSSAAPLTKSSTTAPTTAPKPVTTPVHVGPSTVPHTEAIHVTPSAAPEPTTEPTQSPGYTHLTlSTEAASLQAATEAPLP 774
Cdd:PRK14951   373 AAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPA-AAPAAAPAAVALAPAP 451

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1208037337  775 PPADKP-AVTVPETTSPAASVLSSPSKNMDHIALPTEGPATAQDAWH 820
Cdd:PRK14951   452 PAQAAPeTVAIPVRVAPEPAVASAAPAPAAAPAAARLTPTEEGDVWH 498
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 758-905 1.27e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 50.54  E-value: 1.27e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  758 LSTEAASLQAATEAPLPPPADKPAVTVPETTSPAASVLSSPsknmdhialPTEGPATAQDAWHTDPPttlggSPLHTSPV 837
Cdd:pfam03154  167 LQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVP---------PQGSPATSQPPNQTQST-----AAPHTLIQ 232

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1208037337  838 AAVTPSPQVTsfkwsPSPFPTTEALTSAISSPQMASQVPGSPVVSDDAPGLPGT-ELPVSRLPTSAPPQ 905
Cdd:pfam03154  233 QTPTLHPQRL-----PSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSlQTGPSHMQHPVPPQ 296
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 673-905 1.72e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 50.17  E-value: 1.72e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  673 AACEEGVIIYNERAQIPTSIVYPSSAAPLTKSSTTAPTTA-------PKPVTTPVHVGPSTVP-----------HTEAIH 734
Cdd:PHA03307    70 GPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPgpsspdpPPPTPPPASPPPSPAPdlsemlrpvgsPGPPPA 149

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  735 VTPSAAPEPTTEPtQSPGYTHLTLSTEAASLQAATEAPLPPPADKPAVTVPETTSPAASVLSSP--SKNMDHIALPTEGP 812
Cdd:PHA03307   150 ASPPAAGASPAAV-ASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPisASASSPAPAPGRSA 228

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  813 A-----TAQDAWHTDPPTTlGGSPLHTSPVAAVTPSPQVTSfKWSPSPFPTTEALTSAISSPqmASQVPGSPVVSDDAPG 887
Cdd:PHA03307   229 AddagaSSSDSSSSESSGC-GWGPENECPLPRPAPITLPTR-IWEASGWNGPSSRPGPASSS--SSPRERSPSPSPSSPG 304

                          250
                   ....*....|....*...
gi 1208037337  888 LPGTELPVSRLPTSAPPQ 905
Cdd:PHA03307   305 SGPAPSSPRASSSSSSSR 322
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 722-906 1.72e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 49.98  E-value: 1.72e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  722 VGPSTVPH--TEAIHVTPSAAPEPTTEPTQSPGYThltlSTEAASLQAATEAPLPPPADKPAVTVPETTSPAASVLSSPS 799
Cdd:PRK07764   588 VGPAPGAAggEGPPAPASSGPPEEAARPAAPAAPA----APAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDAS 663

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  800 KNMDHIALPTEGPATAQDAWHTDPPTTLGGSPlHTSPVAAVTPSPQVTSFKW-SPSPFPTTEALTSAISSPQMASQVPGS 878
Cdd:PRK07764   664 DGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAG-AAPAQPAPAPAATPPAGQAdDPAAQPPQAAQGASAPSPAADDPVPLP 742

                          170       180
                   ....*....|....*....|....*...
gi 1208037337  879 PVVSDDAPGLPGTELPVSRLPTSAPPQW 906
Cdd:PRK07764   743 PEPDDPPDPAGAPAQPPPPPAPAPAAAP 770
Sema_6 cd11242
The Sema domain, a protein interacting module, of class 6 semaphorins (Sema6); Class 6 ...
 225-488 4.28e-05

The Sema domain, a protein interacting module, of class 6 semaphorins (Sema6); Class 6 semaphorins (Sema6s) are membrane associated semaphorins. There are 6 subfamilies named 6A to 6D. Sema6s bind to plexin As in a neuropilin independent fashion. Sema6-plexin A signaling plays important roles in lamina-specific axon projections. Interactions between plexin A2, plexin A4, and Sema6A control lamina-restricted projection of hippocampal mossy fibers. Interactions between Sema6C, Sema6D and plexin A1 shape the stereotypic trajectories of sensory axons in the spinal cord. In addition to axon targeting, Sema6D-plexin A1 interactions influence a wide range of other biological processes. During cardiac development, Sema6D attracts or repels endothelial cells in the cardiac tube depending on the expression patterns of specific coreceptors in addition to plexin A1. Furthermore, Sema6D binds a receptor complex comprising of plexin A1, Trem2 (triggering receptor expressed on myeloid cells 2), and DAP12 on dendritic cells and osteoclasts to mediate T-cell-DC interactions and to control bone development, respectively. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200503 [Multi-domain]  Cd Length: 465  Bit Score: 48.67  E-value: 4.28e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  225 HFIKSFTYHSSVYFLFyrRDLksqSREYKTY-------ISRICLDD---------SHYYSYVELPLLCQSKANT---YSL 285
Cdd:cd11242    174 HFVHAVEYGDYVYFFF--REI---AVEYNTLgkvvfsrVARVCKNDmggsprvleKQWTSFLKARLNCSVPGDShfyFDV 248

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  286 LQAayVTRPgkelaqgqLDTEG-EVLFAAFSAwQASSgklSEESALCVYTMEEVDRLTN------------WT------- 345
Cdd:cd11242    249 LQA--VTDV--------IRINGrPVVLGVFTT-QYNS---IPGSAVCAFDMDDIEKVFEgrfkeqkspdsaWTpvpedrv 314

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  346 ---RDVCYMRDGKSEegtevayiEYDVSSNcvqLPADTL---YAYPCgsdhtpspMASRVP-LEAAPLLEKT--EARLTA 416
Cdd:cd11242    315 pkpRPGCCAGSGSAE--------KYKTSND---FPDDTLnfiKTHPL--------MDEAVPsIINRPWFTRTmvRYRLTQ 375

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  417 VAVNVEDG----HTIAFLGDSRGRLHKVyLGAQGEAHTYASVSIQVNSMVSGD--------------LLFDQLQEHLFVM 478
Cdd:cd11242    376 IAVDNAAGpyqnYTVVFLGSEAGTVLKF-LARIGPSGSNGSVFLEEIDVYNPAkcsydgeedrriigLELDRASHALFVA 454

                          330
                   ....*....|
gi 1208037337  479 TQSMVVKVPI 488
Cdd:cd11242    455 FSGCVIRVPL 464
PRK12727 PRK12727
flagellar biosynthesis protein FlhF;
697-870 4.29e-05

flagellar biosynthesis protein FlhF;


Pssm-ID: 237182 [Multi-domain]  Cd Length: 559  Bit Score: 48.45  E-value: 4.29e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  697 SAAPLTKSSTTApttAPKPVTTPVHVGPSTVPHTEAihvtpsAAPEPTTEPTQSPgyTHLtLSTEAASLQAA--TEAPLP 774
Cdd:PRK12727   110 AAMALRQPVSVP---RQAPAAAPVRAASIPSPAAQA------LAHAAAVRTAPRQ--EHA-LSAVPEQLFADflTTAPVP 177

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  775 PPADKPAVTVPETTSPAAsvlsspsknmdhialPTEGPATAQDAWHTDPPTTLGGSPLHTSPVAAVTPSPQVTSFKWSPS 854
Cdd:PRK12727   178 RAPVQAPVVAAPAPVPAI---------------AAALAAHAAYAQDDDEQLDDDGFDLDDALPQILPPAALPPIVVAPAA 242

                          170
                   ....*....|....*.
gi 1208037337  855 PfPTTEALTSAISSPQ 870
Cdd:PRK12727   243 P-AALAAVAAAAPAPQ 257
PHA03378 PHA03378
EBNA-3B; Provisional
 686-905 5.08e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 48.52  E-value: 5.08e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  686 AQIPTSIVYPSSAA-PLTKSSTTAPTTAPKPVTTPVHVGPSTVPHTEAIHVTPSAAPEPTTEPTQSPGY----------- 753
Cdd:PHA03378   593 AQTPWPVPHPSQTPePPTTQSHIPETSAPRQWPMPLRPIPMRPLRMQPITFNVLVFPTPHQPPQVEITPykptwtqighi 672

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  754 ----------THLTLSTEAASLQ--AATEAPLPPPADKPAVTVP--ETTSPAASVLSSPSKNMDHIALPTEGPATAQDAW 819
Cdd:PHA03378   673 pyqpsptganTMLPIQWAPGTMQppPRAPTPMRPPAAPPGRAQRpaAATGRARPPAAAPGRARPPAAAPGRARPPAAAPG 752

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  820 HTDPPTTLGGS---PLHTSPVAAVTPSPQVTSF-----KWSPSPFPTTEAL-TSAISSPQMAS--QVPGSPVVSDDAPGL 888
Cdd:PHA03378   753 RARPPAAAPGRarpPAAAPGAPTPQPPPQAPPApqqrpRGAPTPQPPPQAGpTSMQLMPRAAPgqQGPTKQILRQLLTGG 832

                          250
                   ....*....|....*..
gi 1208037337  889 PGTELPVSRLPTSAPPQ 905
Cdd:PHA03378   833 VKRGRPSLKKPAALERQ 849
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 695-904 5.27e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 48.63  E-value: 5.27e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  695 PSSAAPLTKSSTTAPTTAPKPVTTPVHVGPSTVPHTeaihVTPSAAPEPTTEPTQSPGYTHLTLSTEAASLQAATEAPLP 774
Cdd:PHA03307   151 SPPAAGASPAAVASDAASSRQAALPLSSPEETARAP----SSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGR 226

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  775 PPADKPAVTVP----------------ETTSPAASVLSSPSKNMDHIAlPTEGPATAQDAWHTDPPTTLGGSPLHTSPVA 838
Cdd:PHA03307   227 SAADDAGASSSdssssessgcgwgpenECPLPRPAPITLPTRIWEASG-WNGPSSRPGPASSSSSPRERSPSPSPSSPGS 305

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1208037337  839 AVTPSPQVTSFKWSPSPFPTTEALTSAISSPQMASQVPGSPVVSDDAPGLPGTELPVSRLPTSAPP 904
Cdd:PHA03307   306 GPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRP 371
DamX COG3266
Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell ...
 692-792 6.19e-05

Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442497 [Multi-domain]  Cd Length: 455  Bit Score: 47.92  E-value: 6.19e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  692 IVYPSSAAPLTKSSTTAPTTAPKPVTTPVHVGPSTVPHTEAihvTPSAAPEPTTEPTQSPGYTHLTLSTEAASLQAATEA 771
Cdd:COG3266    250 IIGSALKAPSQASSASAPATTSLGEQQEVSLPPAVAAQPAA---AAAAQPSAVALPAAPAAAAAAAAPAEAAAPQPTAAK 326

                           90       100
                   ....*....|....*....|.
gi 1208037337  772 PLPPPADKPAVTVPETTSPAA 792
Cdd:COG3266    327 PVVTETAAPAAPAPEAAAAAA 347
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 684-887 6.84e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 48.06  E-value: 6.84e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  684 ERAQIPTSIVYPSSAAPLTKSSTTAPTTAPKPVTTPVHVGP-STVPHTEAIHVTPSAAPEPTTEPTQSPGYTHLTLSTEA 762
Cdd:PRK07764   598 EGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEaSAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAA 677

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  763 ASLQAATEAPLPPPADKPAVTVPETTSPAASVLSSPSknmdhIALPTEGPATAQDAWhTDPPTTLGGSPLHTSPVAAVTP 842
Cdd:PRK07764   678 PAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQA-----DDPAAQPPQAAQGAS-APSPAADDPVPLPPEPDDPPDP 751

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1208037337  843 SPQvtsfKWSPSPFPTTEALTSAISSPQMASQVPGSPVVSDDAPG 887
Cdd:PRK07764   752 AGA----PAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAPS 792
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 1092-1131 8.93e-05

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 41.92  E-value: 8.93e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1208037337 1092 NCSvGHTDCSRCQTADSkYNCVWCGGDNpSCIFRGSCKEE 1131
Cdd:pfam01437    1 RCS-QYTSCSSCLAARD-PYCGWCSSEG-RCVRRSACGAP 37
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
1092-1137 9.26e-05

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 41.76  E-value: 9.26e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 1208037337  1092 NCSVgHTDCSRCQTADSKYnCVWCGGDNpSCIFRGSCKEEVEDL----CP 1137
Cdd:smart00423    1 RCSK-YTSCSECLLARDPY-CAWCSSQG-RCTSGERCDSRRQNWlsggCP 47
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 700-814 1.29e-04

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 47.58  E-value: 1.29e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  700 PLTKSSTTAPTTAPKPVTTPVHVGPSTVPHTEaihvtPSAAPEPTTEPTQSPgythltlsTEAASLQAATEAPLPPPADK 779
Cdd:PRK12270    38 PGSTAAPTAAAAAAAAAASAPAAAPAAKAPAA-----PAPAPPAAAAPAAPP--------KPAAAAAAAAAPAAPPAAAA 104

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1208037337  780 PAVTVPETTSPAASVLSSPS----KNMD-HIALPTegpAT 814
Cdd:PRK12270   105 AAAPAAAAVEDEVTPLRGAAaavaKNMDaSLEVPT---AT 141
PRK10856 PRK10856
cytoskeleton protein RodZ;
698-793 1.51e-04

cytoskeleton protein RodZ;


Pssm-ID: 236776 [Multi-domain]  Cd Length: 331  Bit Score: 46.17  E-value: 1.51e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  698 AAPLTKSSTTAPTTAPKPVTTPvhvgPSTVPHTEAIHVTPSAAPEPT------TEPTQSPgythltlSTEAASLQAATEA 771
Cdd:PRK10856   161 SVPLDTSTTTDPATTPAPAAPV----DTTPTNSQTPAVATAPAPAVDpqqnavVAPSQAN-------VDTAATPAPAAPA 229

                           90       100
                   ....*....|....*....|..
gi 1208037337  772 PLPPPADKPAVTVPETTSPAAS 793
Cdd:PRK10856   230 TPDGAAPLPTDQAGVSTPAADP 251
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1231-1309 2.28e-04

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 42.30  E-value: 2.28e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1231 PELKSIVPTQGPKAGGTCLTLLGSKLltG-HPNEI--SVLLGDLPCQIL--SEMTEDQLACQTSPS-NVSTELPVTIKYG 1304
Cdd:cd01180      1 PVITEFFPLSGPLEGGTRLTICGSNL--GlRKNDVrhGVRVGGVPCNPEppEYSSSEKIVCTTGPAgNPVFNGPVEVTVG 78


                   ....*
gi 1208037337 1305 EQERR 1309
Cdd:cd01180     79 HGSFR 83
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 689-776 2.41e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 46.34  E-value: 2.41e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  689 PTSIVYPSSAAPLTKSSTTAPTTAPKPvttPVHVGPSTVPHTEAIHVTPSAAPEPTTEPTQSPGYTHLTLSTEAASLQAA 768
Cdd:PRK14950   365 APQPAKPTAAAPSPVRPTPAPSTRPKA---AAAANIPPKEPVRETATPPPVPPRPVAPPVPHTPESAPKLTRAAIPVDEK 441


                   ....*...
gi 1208037337  769 TEAPLPPP 776
Cdd:PRK14950   442 PKYTPPAP 449
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 762-900 2.94e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 46.13  E-value: 2.94e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  762 AASLQAATEAPLPPPADKPAVTVPETTSPAAsvlsspsknmdhiALPTEGPATAQDawhtdPPTTLGGSPLHTSPVAAVT 841
Cdd:PRK07764   398 APSAAAAAPAAAPAPAAAAPAAAAAPAPAAA-------------PQPAPAPAPAPA-----PPSPAGNAPAGGAPSPPPA 459

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1208037337  842 PSPqvtsfkwSPSPFPTTEALTSAISSPQMASQVPGSPVVSDDAPGLPGTELPVSRLPT 900
Cdd:PRK07764   460 AAP-------SAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAAT 511
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 695-870 3.45e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 45.75  E-value: 3.45e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  695 PSSAAPLTKSSTTAPTTAPKPVTTPVHVgPSTVPHTEAIHVTPSAAPEPTTEPTQSPGYTHLTLSTEAASLQAATEAPLP 774
Cdd:PRK07764   630 AGAAAAPAEASAAPAPGVAAPEHHPKHV-AVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAAT 708

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  775 PPADKPAVTVPETTSPAASVLSSPSKNMDHIALPTEGPATAQDAWHTDPPTtlggSPLHTSPVAAVTPSPQVtsfkwsPS 854
Cdd:PRK07764   709 PPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPP----PPPAPAPAAAPAAAPPP------SP 778

                          170
                   ....*....|....*.
gi 1208037337  855 PFPTTEALTSAISSPQ 870
Cdd:PRK07764   779 PSEEEEMAEDDAPSMD 794
RasGAP cd04519
Ras GTPase Activating Domain; RasGAP functions as an enhancer of the hydrolysis of GTP that is ...
 1682-1792 3.62e-04

Ras GTPase Activating Domain; RasGAP functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Proteins having a RasGAP domain include p120GAP, IQGAP, Rab5-activating protein 6, and Neurofibromin, among others. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP exhibit no similarity at their amino acid sequence level. RasGTPases function as molecular switches in a large number of signaling pathways. They are in the on state when bound to GTP, and in the off state when bound to GDP. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213328  Cd Length: 256  Bit Score: 44.79  E-value: 3.62e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1682 LFLTKFIHTL--EIQRTFSPRDRAYVASLLTVSLHGKlEYFTDILKTLLNDLVEQyvAKNPKLMLRRTeTVVEKLLTNWM 1759
Cdd:cd04519      8 LLLTESPLALlrELSQVLPVKDKEEVATALLRIFESR-GLALEFLRYLVRSEVKN--TKNPNTLFRGN-SLATKLLDQYM 83

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1208037337 1760 SICLYAFVRDSVGEPLYMLFRGIKHQVDKGPVD 1792
Cdd:cd04519     84 KLVGQEYLKETLSPLIREILESKESCEIDTKLP 116
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 695-880 4.66e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 45.24  E-value: 4.66e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  695 PSSAAPLTKSSTTAPTTAPKPVTTPVHVGPSTVPHTEAihVTPSAAPEPTTEPTQSPGYTHLTLSTEAASLQAATEAPLP 774
Cdd:PRK07994   361 PAAPLPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPA--VPPPPASAPQQAPAVPLPETTSQLLAARQQLQRAQGATKA 438

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  775 PPADKPAVTVPETTSPAASVLSSPSknmdHIALPTEGPATAQDAWHTDPPTtlggsPLHTSPVAAVTPSPQVTSFKWSPS 854
Cdd:PRK07994   439 KKSEPAAASRARPVNSALERLASVR----PAPSALEKAPAKKEAYRWKATN-----PVEVKKEPVATPKALKKALEHEKT 509

                          170       180
                   ....*....|....*....|....*.
gi 1208037337  855 PFPTTEALTSAISSPQMASQVPGSPV 880
Cdd:PRK07994   510 PELAAKLAAEAIERDPWAALVSQLGL 535
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 689-905 4.67e-04

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 45.41  E-value: 4.67e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  689 PTSIVYPSSAAPLTKSSTTAPTTAPKPVTT---------PV---HVGPST--VPHTEAIHvtPSAAPEPTTEPTQSPGYT 754
Cdd:pfam09770  113 QSSAQPPASSLPQYQYASQQSQQPSKPVRTgyekykepePIpdlQVDASLwgVAPKKAAA--PAPAPQPAAQPASLPAPS 190

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  755 HLTLSTEA--ASLQAATEAPLPPPADKPAVT-VPETTSPAASVLSSPSKNMDHIALPTEGPATAQDAWHTDPPTTLGGSP 831
Cdd:pfam09770  191 RKMMSLEEveAAMRAQAKKPAQQPAPAPAQPpAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVTILQRPQ 270

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1208037337  832 LHTSPVAAVTPSPQVTSFKWSPSPFPTTEalTSAISSPQM--ASQVPGSPVVSDDAPGLPGTelPVSRLPTSAPPQ 905
Cdd:pfam09770  271 SPQPDPAQPSIQPQAQQFHQQPPPVPVQP--TQILQNPNRlsAARVGYPQNPQPGVQPAPAH--QAHRQQGSFGRQ 342
PRK10118 PRK10118
flagellar hook length control protein FliK;
715-836 8.98e-04

flagellar hook length control protein FliK;


Pssm-ID: 236652 [Multi-domain]  Cd Length: 408  Bit Score: 44.09  E-value: 8.98e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  715 PVTTPVHVGPSTVPHTEAIHVTPSAAPEPTTEPTQSPGYTHLTLSTEAASLQAATEAPLPPPADKPAVTVPETTSPAASV 794
Cdd:PRK10118   154 DNTTPVADAPSTVLPAEKPTLLTKDMPSAPQDETHTLSSDEHEKGLTSAQLTTAQPDDAPGTPAQPLTPLAAEAQAKAEV 233

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1208037337  795 LSSPSkNMDHIALPTEGPATAQdawhtdpPTTLGGSPLHTSP 836
Cdd:PRK10118   234 ISTPS-PVTAAASPTITPHQTQ-------PLPTAAAPVLSAP 267
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1321-1443 1.30e-03

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 39.75  E-value: 1.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337 1321 PNITFAEPPKSFLSGGRVLRVHGYNLDVVQKPkIRVTVspserrrrgvgrwrriipdsecpedslcsiqqFEEPCLIN-- 1398
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPR-VRVTV--------------------------------GGVPCKVLnv 47

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1208037337 1399 SSYLILCKTPAINlLLRSVRIKLEFILDNLSFDFNSlhPMPFSYE 1443
Cdd:cd00603     48 SSTEIVCRTPAAA-TPGEGPVEVTVDGANVSARVLS--NTTFTYV 89
PHA03369 PHA03369
capsid maturational protease; Provisional
 670-801 1.46e-03

capsid maturational protease; Provisional


Pssm-ID: 223061 [Multi-domain]  Cd Length: 663  Bit Score: 43.83  E-value: 1.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  670 THKAACEEGVIIYNERAQIPTSIVYPSSAAPLT-----KSSTTAPTTAPKPVT----TPVHVGPSTVPHTEAIHVTPSAA 740
Cdd:PHA03369   518 NAGAKTAAANIEPNCSADAAAPATKRARPETKTeleavVRFPYQIRNMESPAFvhsfTSTTLAAAAGQGSDTAEALAGAI 597

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1208037337  741 PEPTTEPTQSPGYTHLTLSteAASLQAATEAPLPPPADKPAVTVPETTSPAASVlSSPSKN 801
Cdd:PHA03369   598 ETLLTQASAQPAGLSLPAP--AVPVNASTPASTPPPLAPQEPPQPGTSAPSLET-SLPQQK 655
PHA03291 PHA03291
envelope glycoprotein I; Provisional
 695-808 2.49e-03

envelope glycoprotein I; Provisional


Pssm-ID: 223033 [Multi-domain]  Cd Length: 401  Bit Score: 42.63  E-value: 2.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  695 PSSAAPLTKSSTTAPTTAPKPVTTPvhvgpsTVPHTEAihvTPSAAPEPTTEPTQSPGYTHLTlsTEAASLQAATEAPLP 774
Cdd:PHA03291   191 PLSAPRLGPADVFVPATPRPTPRTT------ASPETTP---TPSTTTSPPSTTIPAPSTTIAA--PQAGTTPEAEGTPAP 259

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1208037337  775 P-PADKPAVTVPETTSPAASVLSSPSKNMDHIALP 808
Cdd:PHA03291   260 PtPGGGEAPPANATPAPEASRYELTVTQIIQIAIP 294
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
650-679 4.65e-03

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 37.14  E-value: 4.65e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1208037337   650 CQKCVSSLWG-CNWCIQQHLCTHKAACEEGV 679
Cdd:smart00423    8 CSECLLARDPyCAWCSSQGRCTSGERCDSRR 38
PRK10856 PRK10856
cytoskeleton protein RodZ;
671-778 4.68e-03

cytoskeleton protein RodZ;


Pssm-ID: 236776 [Multi-domain]  Cd Length: 331  Bit Score: 41.55  E-value: 4.68e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208037337  671 HKAACEE---------GVIIYNERAQIPTSIVYPSSAAPLTKSSTTAPTTAPKPVTTPVHVGPSTVPHTEAIHVTPSAAP 741
Cdd:PRK10856   136 HKAQQEEittmadqssAELSQNSGQSVPLDTSTTTDPATTPAPAAPVDTTPTNSQTPAVATAPAPAVDPQQNAVVAPSQA 215

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1208037337  742 EPTTEPTQSPGYThlTLSTEAASLQAATEAPLPPPAD 778
Cdd:PRK10856   216 NVDTAATPAPAAP--ATPDGAAPLPTDQAGVSTPAAD 250
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 650-675 8.19e-03

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 36.53  E-value: 8.19e-03
                           10        20
                   ....*....|....*....|....*..
gi 1208037337  650 CQKCVSSL-WGCNWCIQQHLCTHKAAC 675
Cdd:pfam01437    8 CSSCLAARdPYCGWCSSEGRCVRRSAC 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH