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Conserved domains on  [gi|136503|sp|P03978|]
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RecName: Full=T-cell receptor gamma chain V region V108B; Flags: Precursor

Protein Classification

immunoglobulin domain-containing family protein( domain architecture ID 34076)

immunoglobulin (Ig) domain-containing family protein is a member of a large superfamily containing cell surface antigen receptors, co-receptors and co-stimulatory molecules of the immune system, molecules involved in antigen presentation to lymphocytes, cell adhesion molecules, certain cytokine receptors and intracellular muscle proteins; immunoglobulin domains are typically divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 20-114 7.18e-43

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd04982:

Pssm-ID: 472250  Cd Length: 117  Bit Score: 136.34  E-value: 7.18e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 136503    20 LEQTELSVTRETDESAQISCIVSLPYFSNTAIHWYRQKA-KKFEYLIYVSTNYNQRPLGGKNK-KIEASKDFQTSTSTLK 97
Cdd:cd04982   1 LEQPQLSITREESKSVTISCKVSGIDFSTTYIHWYRQKPgQALERLLYVSSTSAVRKDSGKTKnKFEARKDVGKSTSTLT 80

                        90
                ....*....|....*..
gi 136503    98 INYLKKEDEATYYCAVW 114
Cdd:cd04982  81 ITNLEKEDSATYYCAYW 97
 
Name Accession Description Interval E-value
IgV_TCR_gamma cd04982
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here ...
 20-114 7.18e-43

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigens as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain the standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409371  Cd Length: 117  Bit Score: 136.34  E-value: 7.18e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 136503    20 LEQTELSVTRETDESAQISCIVSLPYFSNTAIHWYRQKA-KKFEYLIYVSTNYNQRPLGGKNK-KIEASKDFQTSTSTLK 97
Cdd:cd04982   1 LEQPQLSITREESKSVTISCKVSGIDFSTTYIHWYRQKPgQALERLLYVSSTSAVRKDSGKTKnKFEARKDVGKSTSTLT 80

                        90
                ....*....|....*..
gi 136503    98 INYLKKEDEATYYCAVW 114
Cdd:cd04982  81 ITNLEKEDSATYYCAYW 97
IGv smart00406
Immunoglobulin V-Type;
34-113 2.41e-13

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 60.09  E-value: 2.41e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 136503       34 SAQISCIVSLPYFSNTAIHWYRQK-AKKFEYLIYVSTNYNQRPLGGKNKKIEASKDFQTSTSTLKINYLKKEDEATYYCA 112
Cdd:smart00406   1 SVTLSCKFSGSTFSSYYVSWVRQPpGKGLEWLGYIGSNGSSYYQESYKGRFTISKDTSKNDVSLTISNLRVEDTGTYYCA 80


                   .
gi 136503      113 V 113
Cdd:smart00406  81 V 81
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 22-114 3.17e-11

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 55.54  E-value: 3.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 136503      22 QTELSVTRETDESAQISCIVSLPYFS-NTAIHWYRQKA-KKFEYLIYVSTNYNQRPLGGKnkKIEASKDFQTSTSTLKIN 99
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSMSEaSTSVYWYRQPPgKGPTFLIAYYSNGSEEGVKKG--RFSGRGDPSNGDGSLTIQ 78

                          90
                  ....*....|....*
gi 136503     100 YLKKEDEATYYCAVW 114
Cdd:pfam07686  79 NLTLSDSGTYTCAVI 93
 
Name Accession Description Interval E-value
IgV_TCR_gamma cd04982
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here ...
 20-114 7.18e-43

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigens as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain the standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409371  Cd Length: 117  Bit Score: 136.34  E-value: 7.18e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 136503    20 LEQTELSVTRETDESAQISCIVSLPYFSNTAIHWYRQKA-KKFEYLIYVSTNYNQRPLGGKNK-KIEASKDFQTSTSTLK 97
Cdd:cd04982   1 LEQPQLSITREESKSVTISCKVSGIDFSTTYIHWYRQKPgQALERLLYVSSTSAVRKDSGKTKnKFEARKDVGKSTSTLT 80

                        90
                ....*....|....*..
gi 136503    98 INYLKKEDEATYYCAVW 114
Cdd:cd04982  81 ITNLEKEDSATYYCAYW 97
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 20-114 1.04e-25

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 92.78  E-value: 1.04e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 136503    20 LEQTELSVTRETDESAQISCIVSLPyFSNTAIHWYRQK-AKKFEYLIYVSTNYNQRPlGGKNKKIEASKDfQTSTSTLKI 98
Cdd:cd00099   1 VTQSPRSLSVQEGESVTLSCEVSSS-FSSTYIYWYRQKpGQGPEFLIYLSSSKGKTK-GGVPGRFSGSRD-GTSSFSLTI 77

                        90
                ....*....|....*.
gi 136503    99 NYLKKEDEATYYCAVW 114
Cdd:cd00099  78 SNLQPEDSGTYYCAVS 93
IGv smart00406
Immunoglobulin V-Type;
34-113 2.41e-13

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 60.09  E-value: 2.41e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 136503       34 SAQISCIVSLPYFSNTAIHWYRQK-AKKFEYLIYVSTNYNQRPLGGKNKKIEASKDFQTSTSTLKINYLKKEDEATYYCA 112
Cdd:smart00406   1 SVTLSCKFSGSTFSSYYVSWVRQPpGKGLEWLGYIGSNGSSYYQESYKGRFTISKDTSKNDVSLTISNLRVEDTGTYYCA 80


                   .
gi 136503      113 V 113
Cdd:smart00406  81 V 81
IgV_L_lambda cd04984
Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of ...
 26-114 4.69e-13

Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, lambda type, variable (V) domain. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409373  Cd Length: 105  Bit Score: 60.17  E-value: 4.69e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 136503    26 SVTRETDESAQISCIVSLPYFSNTAIHWYRQKA-KKFEYLIYVStnyNQRPlGGKNKKIEASKDfqTSTSTLKINYLKKE 104
Cdd:cd04984   7 SLSVSPGETVTITCTGSSGNISGNYVNWYQQKPgSAPRYLIYED---KHRP-SGIPDRFSGSKS--GNTASLTISGAQTE 80

                        90
                ....*....|
gi 136503   105 DEATYYCAVW 114
Cdd:cd04984  81 DEADYYCQVW 90
IgV_H cd04981
Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the ...
 19-112 2.87e-12

Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the immunoglobulin (Ig) heavy chain (H), variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains.


Pssm-ID: 409370 [Multi-domain]  Cd Length: 118  Bit Score: 58.48  E-value: 2.87e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 136503    19 QLEQTElSVTRETDESAQISCIVSLPYFSNTAIHWYRQKAKK------FEYLIYVSTNYNQRPLGgknkKIEASKDFQTS 92
Cdd:cd04981   1 QLQESG-PGLVKPGQSLKLSCKASGFTFTSYGMGWVRQAPGKglewigLIYPGGGDTYYADSFKG----RFTITRDTSKS 75

                        90       100
                ....*....|....*....|
gi 136503    93 TSTLKINYLKKEDEATYYCA 112
Cdd:cd04981  76 TAYLQLNSLTSEDTAVYYCA 95
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 22-114 3.17e-11

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 55.54  E-value: 3.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 136503      22 QTELSVTRETDESAQISCIVSLPYFS-NTAIHWYRQKA-KKFEYLIYVSTNYNQRPLGGKnkKIEASKDFQTSTSTLKIN 99
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSMSEaSTSVYWYRQPPgKGPTFLIAYYSNGSEEGVKKG--RFSGRGDPSNGDGSLTIQ 78

                          90
                  ....*....|....*
gi 136503     100 YLKKEDEATYYCAVW 114
Cdd:pfam07686  79 NLTLSDSGTYTCAVI 93
IgV_CD8_beta cd07700
Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The ...
 20-112 8.96e-11

Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The members here are composed of the immunoglobulin (Ig)-like domain in Cluster of Differentiation (CD) 8 beta. The CD8 glycoprotein plays an essential role in the control of T-cell selection, maturation, and the T-cell receptor (TCR)-mediated response to peptide antigen. CD8 is comprised of alpha and beta subunits and is expressed as either an alpha/alpha or alpha/beta dimer. Both dimeric isoforms can serve as a coreceptor for T cell activation and differentiation, however they have distinct physiological roles, different cellular distributions, unique binding partners, etc. Each CD8 subunit is comprised of an extracellular domain containing a V-type Ig-like domain, a single pass transmembrane portion, and a short intracellular domain. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409497  Cd Length: 116  Bit Score: 54.38  E-value: 8.96e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 136503    20 LEQTELSVTRETDESAQISCIVSLpYFSNTAIHWYRQ-----KAKKFEYLiyVSTNYNQRPLGGKNKKIEASKDFQTSTS 94
Cdd:cd07700   1 LLQTPGSLLVQTNQTVKMSCEAKT-SPKNTRIYWLRQrqapsKDSHFEFL--ASWDPSKGIVYGEGVDQEKLIILSDSDS 77

                        90       100
                ....*....|....*....|.
gi 136503    95 ---TLKINYLKKEDEATYYCA 112
Cdd:cd07700  78 sryILSLMSVKPEDSGTYFCM 98
IgV_TCR_alpha cd04983
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar ...
 21-113 3.86e-10

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins; The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409372 [Multi-domain]  Cd Length: 109  Bit Score: 52.66  E-value: 3.86e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 136503    21 EQTELSVTRETDESAQISCivSLPYFSNTAIHWYRQK-AKKFEYLIYVSTNynqrplGGKNKKIEASKDFQTST--STLK 97
Cdd:cd04983   2 TQSPQSLSVQEGENVTLNC--NYSTSTFYYLFWYRQYpGQGPQFLIYISSD------SGNKKKGRFSATLDKSRksSSLH 73

                        90
                ....*....|....*.
gi 136503    98 INYLKKEDEATYYCAV 113
Cdd:cd04983  74 ISAAQLSDSAVYFCAL 89
IgV_TCR_beta cd05899
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here ...
 20-113 1.32e-09

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here are composed of the immunoglobulin (Ig) variable domain of the beta chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. This group includes the variable domain of the alpha chain of alpha/beta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409480  Cd Length: 110  Bit Score: 51.51  E-value: 1.32e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 136503    20 LEQTELSVTRETDESAQISCIVSLPYfsnTAIHWYRQKAKKFEYLIYVSTNYNQRPLGG-KNKKIEASKdFQTSTSTLKI 98
Cdd:cd05899   1 VTQSPRYLIKRRGQSVTLRCSQKSGH---DNMYWYRQDPGKGLQLLFYSYGGGLNEEGDlPGDRFSASR-PSLTRSSLTI 76

                        90
                ....*....|....*
gi 136503    99 NYLKKEDEATYYCAV 113
Cdd:cd05899  77 KSAEPEDSAVYLCAS 91
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 26-114 3.74e-08

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 47.11  E-value: 3.74e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 136503       26 SVTRETDESAQISCIVSlpYFSNTAIHWYRQKAKKFEYliyvstnynqrplggkNKKIEASKDfqTSTSTLKINYLKKED 105
Cdd:smart00410   3 SVTVKEGESVTLSCEAS--GSPPPEVTWYKQGGKLLAE----------------SGRFSVSRS--GSTSTLTISNVTPED 62


                   ....*....
gi 136503      106 EATYYCAVW 114
Cdd:smart00410  63 SGTYTCAAT 71
IgV_L_kappa cd04980
Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are ...
 19-111 1.91e-06

Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, kappa type, variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains.


Pssm-ID: 409369  Cd Length: 106  Bit Score: 43.15  E-value: 1.91e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 136503    19 QLEQTELSVTRETDESAQISCIVSLPyFSNTAIHWYRQK---AKKFeyLIYvstnynqrplGGKNKKIEASKDFQTSTS- 94
Cdd:cd04980   2 VMTQSPASLSVSPGERVTISCKASQS-ISSNYLAWYQQKpgqAPKL--LIY----------YASTLHSGVPSRFSGSGSg 68

                        90       100
                ....*....|....*....|
gi 136503    95 ---TLKINYLKKEDEATYYC 111
Cdd:cd04980  69 tdfTLTISSVEPEDAAVYYC 88
IgV_CD8_alpha cd05720
Immunoglobulin (Ig)-like variable (V) domain of Cluster of Differentiation (CD) 8 alpha chain; ...
 39-113 2.73e-04

Immunoglobulin (Ig)-like variable (V) domain of Cluster of Differentiation (CD) 8 alpha chain; The members here are composed of the immunoglobulin (Ig)-like variable domain of the Cluster of Differentiation (CD) 8 alpha. The CD8 glycoprotein plays an essential role in the control of T-cell selection, maturation, and the T-cell receptor (TCR)-mediated response to peptide antigen. CD8 is comprised of alpha and beta subunits and is expressed as either an alpha/alpha or alpha/beta dimer. Both dimeric isoforms can serve as a coreceptor for T cell activation and differentiation, however they have distinct physiological roles, different cellular distributions, unique binding partners, etc. Each CD8 subunit is comprised of an extracellular domain containing a V-type Ig-like domain, a single pass transmembrane portion, and a short intracellular domain. The Ig domain of CD8 alpha binds to antibodies. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409385  Cd Length: 110  Bit Score: 37.46  E-value: 2.73e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 136503    39 CIVSLPyfSNTAIHWYRQ---KAKKFEYLIYVS-TNYNQRPLGGKNKKIEASKdfQTSTSTLKINYLKKEDEATYYCAV 113
Cdd:cd05720  20 CEVLNS--VPQGCSWLFQprgSAPQPTFLLYLSsSNKTKWAEGLDSKRFSGSR--SGSSYVLTLKDFRKEDEGYYFCSV 94
IgV_TCR_delta cd07706
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here ...
 19-112 3.14e-04

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the delta chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing, and MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409503  Cd Length: 112  Bit Score: 37.11  E-value: 3.14e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 136503    19 QLEQTELSVTRETDESAQISCIVSLPYfSNTAIHWYRQK-AKKFEYLIYvstnynQRPLGGKNKKIEASKDFQTSTST-- 95
Cdd:cd07706   1 KVTQAQPDVSVQVGEEVTLNCRYETSW-TNYYLFWYKQLpSGEMTFLIR------QDSSEQNAKSGRYSVNFQKAQKSis 73

                        90
                ....*....|....*..
gi 136503    96 LKINYLKKEDEATYYCA 112
Cdd:cd07706  74 LTISALQLEDSAKYFCA 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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