NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|408359967|sp|P09813|]
View 

RecName: Full=Apolipoprotein A-II; Short=Apo-AII; Short=ApoA-II; AltName: Full=Apolipoprotein A2; Contains: RecName: Full=Proapolipoprotein A-II; Short=ProapoA-II; Flags: Precursor

Protein Classification

ApoA-II domain-containing protein( domain architecture ID 10520240)

ApoA-II domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ApoA-II pfam04711
Apolipoprotein A-II (ApoA-II); Apolipoprotein A-II (ApoA-II) is the second major ...
 1-100 1.23e-54

Apolipoprotein A-II (ApoA-II); Apolipoprotein A-II (ApoA-II) is the second major apolipoprotein of high density lipoprotein in human plasma. Mature ApoA-II is present as a dimer of two 77-amino acid chains joined by a disulphide bridge. ApoA-II regulates many steps in HDL metabolism, and its role in coronary heart disease is unclear. In bovine serum, the ApoA-II homolog is present in almost free form. Bovine ApoA-II shows antimicrobial activity against Escherichia coli and yeasts in phosphate buffered saline (PBS).


:

Pssm-ID: 461404  Cd Length: 99  Bit Score: 164.94  E-value: 1.23e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 408359967    1 MKLLAMVALLVTICSLEGALVKRQADGPDMQSLFTQYFQSMTDYGKDLMEKAKTSEIQSQAKAYFEKTHEQLTPLVRSAG 80
Cdd:pfam04711   1 MKLLAMTVLLLTICSLEGALVRRQAEEPDLQSLFSQYFQTLTDYGKDLVEKAKGPELQAQAKAYFEKTQEQLTPLVKKAG 80

                          90       100
                  ....*....|....*....|
gi 408359967   81 TSLVNFFSSLMNLeEKPAPA 100
Cdd:pfam04711  81 TDLMNFFSNFVDL-KKPQPA 99
 
Name Accession Description Interval E-value
ApoA-II pfam04711
Apolipoprotein A-II (ApoA-II); Apolipoprotein A-II (ApoA-II) is the second major ...
 1-100 1.23e-54

Apolipoprotein A-II (ApoA-II); Apolipoprotein A-II (ApoA-II) is the second major apolipoprotein of high density lipoprotein in human plasma. Mature ApoA-II is present as a dimer of two 77-amino acid chains joined by a disulphide bridge. ApoA-II regulates many steps in HDL metabolism, and its role in coronary heart disease is unclear. In bovine serum, the ApoA-II homolog is present in almost free form. Bovine ApoA-II shows antimicrobial activity against Escherichia coli and yeasts in phosphate buffered saline (PBS).


Pssm-ID: 461404  Cd Length: 99  Bit Score: 164.94  E-value: 1.23e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 408359967    1 MKLLAMVALLVTICSLEGALVKRQADGPDMQSLFTQYFQSMTDYGKDLMEKAKTSEIQSQAKAYFEKTHEQLTPLVRSAG 80
Cdd:pfam04711   1 MKLLAMTVLLLTICSLEGALVRRQAEEPDLQSLFSQYFQTLTDYGKDLVEKAKGPELQAQAKAYFEKTQEQLTPLVKKAG 80

                          90       100
                  ....*....|....*....|
gi 408359967   81 TSLVNFFSSLMNLeEKPAPA 100
Cdd:pfam04711  81 TDLMNFFSNFVDL-KKPQPA 99
 
Name Accession Description Interval E-value
ApoA-II pfam04711
Apolipoprotein A-II (ApoA-II); Apolipoprotein A-II (ApoA-II) is the second major ...
 1-100 1.23e-54

Apolipoprotein A-II (ApoA-II); Apolipoprotein A-II (ApoA-II) is the second major apolipoprotein of high density lipoprotein in human plasma. Mature ApoA-II is present as a dimer of two 77-amino acid chains joined by a disulphide bridge. ApoA-II regulates many steps in HDL metabolism, and its role in coronary heart disease is unclear. In bovine serum, the ApoA-II homolog is present in almost free form. Bovine ApoA-II shows antimicrobial activity against Escherichia coli and yeasts in phosphate buffered saline (PBS).


Pssm-ID: 461404  Cd Length: 99  Bit Score: 164.94  E-value: 1.23e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 408359967    1 MKLLAMVALLVTICSLEGALVKRQADGPDMQSLFTQYFQSMTDYGKDLMEKAKTSEIQSQAKAYFEKTHEQLTPLVRSAG 80
Cdd:pfam04711   1 MKLLAMTVLLLTICSLEGALVRRQAEEPDLQSLFSQYFQTLTDYGKDLVEKAKGPELQAQAKAYFEKTQEQLTPLVKKAG 80

                          90       100
                  ....*....|....*....|
gi 408359967   81 TSLVNFFSSLMNLeEKPAPA 100
Cdd:pfam04711  81 TDLMNFFSNFVDL-KKPQPA 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH