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Conserved domains on  [gi|416578|sp|P32463|]
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RecName: Full=Acyl carrier protein, mitochondrial; Short=ACP; AltName: Full=NADH-ubiquinone oxidoreductase 9.6 kDa subunit; Flags: Precursor

Protein Classification

acyl carrier protein( domain architecture ID 10015675)

acyl carrier protein functions as the carrier of the growing fatty acid chain in fatty acid biosynthesis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
acyl_carrier TIGR00517
acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser ...
 46-122 7.07e-35

acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser residue. It acts as a carrier of the growing fatty acid chain, which is bound to the prosthetic group, during fatty acid biosynthesis. Homologous phosphopantetheine-binding domains are found in longer proteins. Acyl carrier proteins scoring above the noise cutoff but below the trusted cutoff may be specialized versions. These include those involved in mycolic acid biosynthesis in the Mycobacteria, lipid A biosynthesis in Rhizobium, actinorhodin polyketide synthesis in Streptomyces coelicolor, etc. This protein is not found in the Archaea.Gene name acpP.S (Ser) at position 37 in the seed alignment, in the motif DSLD, is the phosphopantetheine attachment site. [Fatty acid and phospholipid metabolism, Biosynthesis]


:

Pssm-ID: 213536 [Multi-domain]  Cd Length: 77  Bit Score: 115.19  E-value: 7.07e-35
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 416578      46 SQRVIDVIKAFDKNSPNIANKQISSDTQFHKDLGLDSLDTVELLVAIEEEFDIEIPDKVADELRSVGETVDYIASNP 122
Cdd:TIGR00517   1 MQEIFEKVKAIIKEQLNVDEDQITTDARFVEDLGADSLDTVELVMALEEEFDIEIPDEEAEKIATVGDAVNYIEENQ 77
 
Name Accession Description Interval E-value
acyl_carrier TIGR00517
acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser ...
 46-122 7.07e-35

acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser residue. It acts as a carrier of the growing fatty acid chain, which is bound to the prosthetic group, during fatty acid biosynthesis. Homologous phosphopantetheine-binding domains are found in longer proteins. Acyl carrier proteins scoring above the noise cutoff but below the trusted cutoff may be specialized versions. These include those involved in mycolic acid biosynthesis in the Mycobacteria, lipid A biosynthesis in Rhizobium, actinorhodin polyketide synthesis in Streptomyces coelicolor, etc. This protein is not found in the Archaea.Gene name acpP.S (Ser) at position 37 in the seed alignment, in the motif DSLD, is the phosphopantetheine attachment site. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 213536 [Multi-domain]  Cd Length: 77  Bit Score: 115.19  E-value: 7.07e-35
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 416578      46 SQRVIDVIKAFDKNSPNIANKQISSDTQFHKDLGLDSLDTVELLVAIEEEFDIEIPDKVADELRSVGETVDYIASNP 122
Cdd:TIGR00517   1 MQEIFEKVKAIIKEQLNVDEDQITTDARFVEDLGADSLDTVELVMALEEEFDIEIPDEEAEKIATVGDAVNYIEENQ 77
PTZ00171 PTZ00171
acyl carrier protein; Provisional
 40-122 3.13e-20

acyl carrier protein; Provisional


Pssm-ID: 240304  Cd Length: 148  Bit Score: 80.13  E-value: 3.13e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 416578     40 LSKDQVSQRVIDVIKAFDKnspnIANKQISSDTQFHKDLGLDSLDTVELLVAIEEEFDIEIPDKVADELRSVGETVDYIA 119
Cdd:PTZ00171  66 LSKEDVLTRVKKVVKNFEK----VDASKITPESNFVKDLGADSLDVVELLIAIEQEFNLTIPDHDAEKIKTVQDAIDYIE 141


                 ...
gi 416578    120 SNP 122
Cdd:PTZ00171 142 QNN 144
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 62-121 7.78e-17

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 69.50  E-value: 7.78e-17
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 416578    62 NIANKQISSDTQFHKDLGLDSLDTVELLVAIEEEFDIEIPDKVADELRSVGETVDYIASN 121
Cdd:COG0236  19 GVDPEEITPDDSFFEDLGLDSLDAVELIAALEEEFGIELPDTELFEYPTVADLADYLEEK 78
PP-binding pfam00550
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 62-113 1.37e-09

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


Pssm-ID: 425746 [Multi-domain]  Cd Length: 62  Bit Score: 50.25  E-value: 1.37e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 416578      62 NIANKQISSDTQFHkDLGLDSLDTVELLVAIEEEFDIEIPDKVADELRSVGE 113
Cdd:pfam00550  12 GVPAEEIDPDTDLF-DLGLDSLLAVELIARLEEEFGVEIPPSDLFEHPTLAE 62
PKS_PP smart00823
Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the ...
 68-120 1.76e-04

Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the prosthetic group of acyl carrier proteins (ACP) in some multienzyme complexes where it serves as a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups.


Pssm-ID: 214834 [Multi-domain]  Cd Length: 86  Bit Score: 37.61  E-value: 1.76e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 416578       68 ISSDTQFhKDLGLDSLDTVELLVAIEEEFDIEIPDKVADELRSVGETVDYIAS 120
Cdd:smart00823  33 IDPDRPF-RDLGLDSLMAVELRNRLEAATGLRLPATLVFDHPTPAALAEHLAA 84
 
Name Accession Description Interval E-value
acyl_carrier TIGR00517
acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser ...
 46-122 7.07e-35

acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser residue. It acts as a carrier of the growing fatty acid chain, which is bound to the prosthetic group, during fatty acid biosynthesis. Homologous phosphopantetheine-binding domains are found in longer proteins. Acyl carrier proteins scoring above the noise cutoff but below the trusted cutoff may be specialized versions. These include those involved in mycolic acid biosynthesis in the Mycobacteria, lipid A biosynthesis in Rhizobium, actinorhodin polyketide synthesis in Streptomyces coelicolor, etc. This protein is not found in the Archaea.Gene name acpP.S (Ser) at position 37 in the seed alignment, in the motif DSLD, is the phosphopantetheine attachment site. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 213536 [Multi-domain]  Cd Length: 77  Bit Score: 115.19  E-value: 7.07e-35
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 416578      46 SQRVIDVIKAFDKNSPNIANKQISSDTQFHKDLGLDSLDTVELLVAIEEEFDIEIPDKVADELRSVGETVDYIASNP 122
Cdd:TIGR00517   1 MQEIFEKVKAIIKEQLNVDEDQITTDARFVEDLGADSLDTVELVMALEEEFDIEIPDEEAEKIATVGDAVNYIEENQ 77
PTZ00171 PTZ00171
acyl carrier protein; Provisional
 40-122 3.13e-20

acyl carrier protein; Provisional


Pssm-ID: 240304  Cd Length: 148  Bit Score: 80.13  E-value: 3.13e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 416578     40 LSKDQVSQRVIDVIKAFDKnspnIANKQISSDTQFHKDLGLDSLDTVELLVAIEEEFDIEIPDKVADELRSVGETVDYIA 119
Cdd:PTZ00171  66 LSKEDVLTRVKKVVKNFEK----VDASKITPESNFVKDLGADSLDVVELLIAIEQEFNLTIPDHDAEKIKTVQDAIDYIE 141


                 ...
gi 416578    120 SNP 122
Cdd:PTZ00171 142 QNN 144
acpP PRK00982
acyl carrier protein; Provisional
 67-121 1.50e-18

acyl carrier protein; Provisional


Pssm-ID: 179197 [Multi-domain]  Cd Length: 78  Bit Score: 73.67  E-value: 1.50e-18
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 416578     67 QISSDTQFHKDLGLDSLDTVELLVAIEEEFDIEIPDKVADELRSVGETVDYIASN 121
Cdd:PRK00982  22 EVTPEASFVDDLGADSLDTVELVMALEEEFGIEIPDEDAEKIKTVGDAVDYIEKH 76
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 62-121 7.78e-17

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 69.50  E-value: 7.78e-17
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 416578    62 NIANKQISSDTQFHKDLGLDSLDTVELLVAIEEEFDIEIPDKVADELRSVGETVDYIASN 121
Cdd:COG0236  19 GVDPEEITPDDSFFEDLGLDSLDAVELIAALEEEFGIELPDTELFEYPTVADLADYLEEK 78
acpP CHL00124
acyl carrier protein; Validated
 63-121 2.95e-15

acyl carrier protein; Validated


Pssm-ID: 177047 [Multi-domain]  Cd Length: 82  Bit Score: 65.43  E-value: 2.95e-15
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 416578     63 IANKQISSDTQFHKDLGLDSLDTVELLVAIEEEFDIEIPDKVADELRSVGETVDYIASN 121
Cdd:CHL00124  20 IEKSEVTLDANFTRDLGADSLDVVELVMAIEEKFDIEIPDEDAEKISTLQEAVDFISQK 78
PRK12449 PRK12449
acyl carrier protein; Provisional
 40-118 1.17e-11

acyl carrier protein; Provisional


Pssm-ID: 183533 [Multi-domain]  Cd Length: 80  Bit Score: 56.25  E-value: 1.17e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 416578     40 LSKDQVSQRVIDVIKAFDKNsPNIAnkqISSDTQFHKDLGLDSLDTVELLVAIEEEFDIEIPDKVADELRSVGETVDYI 118
Cdd:PRK12449   1 MTREEIFERLINLIQKQRSY-LSLA---ITEQTHLKDDLAVDSIELVEFIINVEDEFHIAIPDEDVEDMVSMGDLLDYL 75
PP-binding pfam00550
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 62-113 1.37e-09

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


Pssm-ID: 425746 [Multi-domain]  Cd Length: 62  Bit Score: 50.25  E-value: 1.37e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 416578      62 NIANKQISSDTQFHkDLGLDSLDTVELLVAIEEEFDIEIPDKVADELRSVGE 113
Cdd:pfam00550  12 GVPAEEIDPDTDLF-DLGLDSLLAVELIARLEEEFGVEIPPSDLFEHPTLAE 62
PRK07081 PRK07081
acyl carrier protein; Provisional
 77-102 4.21e-07

acyl carrier protein; Provisional


Pssm-ID: 180828  Cd Length: 83  Bit Score: 44.56  E-value: 4.21e-07
                         10        20
                 ....*....|....*....|....*.
gi 416578     77 DLGLDSLDTVELLVAIEEEFDIEIPD 102
Cdd:PRK07081  30 EAGLSSLATVQLMLAIEDAFDIEIPD 55
PKS_PP smart00823
Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the ...
 68-120 1.76e-04

Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the prosthetic group of acyl carrier proteins (ACP) in some multienzyme complexes where it serves as a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups.


Pssm-ID: 214834 [Multi-domain]  Cd Length: 86  Bit Score: 37.61  E-value: 1.76e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 416578       68 ISSDTQFhKDLGLDSLDTVELLVAIEEEFDIEIPDKVADELRSVGETVDYIAS 120
Cdd:smart00823  33 IDPDRPF-RDLGLDSLMAVELRNRLEAATGLRLPATLVFDHPTPAALAEHLAA 84
PRK05087 PRK05087
D-alanine--poly(phosphoribitol) ligase subunit DltC;
80-101 2.40e-04

D-alanine--poly(phosphoribitol) ligase subunit DltC;


Pssm-ID: 179929  Cd Length: 78  Bit Score: 37.25  E-value: 2.40e-04
                         10        20
                 ....*....|....*....|..
gi 416578     80 LDSLDTVELLVAIEEEFDIEIP 101
Cdd:PRK05087  34 LDSMGTVELLVELENRFDIEVP 55
PRK05828 PRK05828
acyl carrier protein; Validated
 76-118 1.02e-03

acyl carrier protein; Validated


Pssm-ID: 180278  Cd Length: 84  Bit Score: 35.61  E-value: 1.02e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 416578     76 KDLGLDSLDTVELLVAIEEEFDIEIPDKVADELRSVGETVDYI 118
Cdd:PRK05828  33 RELKIDSLDMFSIIVSLESEFNIEFSDEKLMKLKNLADLILEV 75
PRK06508 PRK06508
acyl carrier protein; Provisional
 48-101 1.96e-03

acyl carrier protein; Provisional


Pssm-ID: 180597  Cd Length: 93  Bit Score: 35.18  E-value: 1.96e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 416578     48 RVIDVIKafdkNSPNIANKQISSDTQFHKDLGLDSLDTVELLVAIEEEFDIEIP 101
Cdd:PRK06508   7 KVADIIA----ETSDIPRDTITPESHTIDDLGIDSLDFLDIVFAIDKAFGIKLP 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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