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Conserved domains on  [gi|47117802|sp|P98159|]
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RecName: Full=Serine protease nudel; Flags: Precursor

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 1145-1379 9.59e-74

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


:

Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 246.03  E-value: 9.59e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117802 1145 IVGGSYTSALQWPFVVAIYRN-GKFHCGGTIYSDRWIISAAHCVINYGKYFYEVRAGLLRRSSYSPATQIQPVSHVVVHQ 1223
Cdd:cd00190    1 IVGGSEAKIGSFPWQVSLQYTgGRHFCGGSLISPRWVLTAAHCVYSSAPSNYTVRLGSHDLSSNEGGGQVIKVKKVIVHP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117802 1224 AYERRSMRNDLSLLRLLNPLQFNRWVKPICLPDKGRTtvgddwiwgPVEHTLCTVVGWGAIREKGPSSDPMRQVIVPI-- 1301
Cdd:cd00190   81 NYNPSTYDNDIALLKLKRPVTLSDNVRPICLPSSGYN---------LPAGTTCTVSGWGRTSEGGPLPDVLQEVNVPIvs 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117802 1302 RKKCTDPEDQASED----ICAGDPDGGRDACQGDSGGPLFCRsvsNPDEFYLAGVVSHGNGCARPQEFGVYTRVTLYLDW 1377
Cdd:cd00190  152 NAECKRAYSYGGTItdnmLCAGGLEGGKDACQGDSGGPLVCN---DNGRGVLVGIVSWGSGCARPNYPGVYTRVSSYLDW 228


                 ..
gi 47117802 1378 LE 1379
Cdd:cd00190  229 IQ 230
DUF1986 pfam09342
Domain of unknown function (DUF1986); This domain is found in serine proteases and is ...
 2041-2158 2.42e-63

Domain of unknown function (DUF1986); This domain is found in serine proteases and is predicted to contain disulphide bonds.


:

Pssm-ID: 286432  Cd Length: 116  Bit Score: 211.64  E-value: 2.42e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117802   2041 WPWLADVYMNGDLWCIGVLIDKHWVMVHESCLSGIDLETHYVSVLLGGGKTKRSAhRSNHEQIRRVDCFEGVPKSNVLLL 2120
Cdd:pfam09342    1 WPWIAKVYLDGNMICSGVLIDASWVIVSGSCLRDTNLRHQYISVVLGGAKTLKSI-EGPYEQIVRVDCRHDIPESEISLL 79

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 47117802   2121 HLERPVRFTHHVLPTFLPDSSHQNQSHArQCISVLHDD 2158
Cdd:pfam09342   80 HLASPASFSNHVLPTFVPETRNENEKDN-ECLAVGQDD 116
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2421-2457 1.74e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.91  E-value: 1.74e-09
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 47117802 2421 CTADHFQCSSSpeDCIPRDFVCDKEKDCPNGEDERYC 2457
Cdd:cd00112    1 CPPNEFRCANG--RCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 891-927 2.09e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.82  E-value: 2.09e-08
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 47117802  891 CPePDQFSCfGQQECIPAARWCDNVVDCSDGSDESAC 927
Cdd:cd00112    1 CP-PNEFRC-ANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1776-1811 2.23e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.13  E-value: 2.23e-07
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 47117802 1776 CQSNEFRCPlSKTCLPLSSRCDNKVDCKFKEDEKDC 1811
Cdd:cd00112    1 CPPNEFRCA-NGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2350-2383 8.06e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 47.24  E-value: 8.06e-07
                            10        20        30
                    ....*....|....*....|....*....|....
gi 47117802    2350 QCAPGEMKCRTSfKCVPKSKFCDHVPDCEDMTDE 2383
Cdd:smart00192    1 TCPPGEFQCDNG-RCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2309-2339 1.84e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 46.47  E-value: 1.84e-06
                            10        20        30
                    ....*....|....*....|....*....|.
gi 47117802    2309 DCSTHRCPLGTCLPQAAMCNGRSDCHDGSDE 2339
Cdd:smart00192    3 PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1399-1430 2.28e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 43.35  E-value: 2.28e-05
                         10        20        30
                 ....*....|....*....|....*....|..
gi 47117802 1399 FICVWGgkRCIAKRQRCDRNVDCLGGEDEVGC 1430
Cdd:cd00112    6 FRCANG--RCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1710-1743 2.47e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 43.35  E-value: 2.47e-05
                         10        20        30
                 ....*....|....*....|....*....|....
gi 47117802 1710 PNKFVCKKMSQIvDIMMRCDRKVDCEDGTDELDC 1743
Cdd:cd00112    3 PNEFRCANGRCI-PSSWVCDGEDDCGDGSDEENC 35
 
Name Accession Description Interval E-value
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 1145-1379 9.59e-74

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 246.03  E-value: 9.59e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117802 1145 IVGGSYTSALQWPFVVAIYRN-GKFHCGGTIYSDRWIISAAHCVINYGKYFYEVRAGLLRRSSYSPATQIQPVSHVVVHQ 1223
Cdd:cd00190    1 IVGGSEAKIGSFPWQVSLQYTgGRHFCGGSLISPRWVLTAAHCVYSSAPSNYTVRLGSHDLSSNEGGGQVIKVKKVIVHP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117802 1224 AYERRSMRNDLSLLRLLNPLQFNRWVKPICLPDKGRTtvgddwiwgPVEHTLCTVVGWGAIREKGPSSDPMRQVIVPI-- 1301
Cdd:cd00190   81 NYNPSTYDNDIALLKLKRPVTLSDNVRPICLPSSGYN---------LPAGTTCTVSGWGRTSEGGPLPDVLQEVNVPIvs 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117802 1302 RKKCTDPEDQASED----ICAGDPDGGRDACQGDSGGPLFCRsvsNPDEFYLAGVVSHGNGCARPQEFGVYTRVTLYLDW 1377
Cdd:cd00190  152 NAECKRAYSYGGTItdnmLCAGGLEGGKDACQGDSGGPLVCN---DNGRGVLVGIVSWGSGCARPNYPGVYTRVSSYLDW 228


                 ..
gi 47117802 1378 LE 1379
Cdd:cd00190  229 IQ 230
Tryp_SPc smart00020
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ...
 1144-1377 1.35e-70

Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.


Pssm-ID: 214473  Cd Length: 229  Bit Score: 236.81  E-value: 1.35e-70
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117802    1144 RIVGGSYTSALQWPFVVAIYRNGKFH-CGGTIYSDRWIISAAHCVINYGKYFYEVRAGLLRRSSYSPATQIQpVSHVVVH 1222
Cdd:smart00020    1 RIVGGSEANIGSFPWQVSLQYGGGRHfCGGSLISPRWVLTAAHCVRGSDPSNIRVRLGSHDLSSGEEGQVIK-VSKVIIH 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117802    1223 QAYERRSMRNDLSLLRLLNPLQFNRWVKPICLPDKGRTtvgddwiwgPVEHTLCTVVGWGAIRE-KGPSSDPMRQVIVPI 1301
Cdd:smart00020   80 PNYNPSTYDNDIALLKLKEPVTLSDNVRPICLPSSNYN---------VPAGTTCTVSGWGRTSEgAGSLPDTLQEVNVPI 150

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117802    1302 --RKKCTD----PEDQASEDICAGDPDGGRDACQGDSGGPLFCRSvsnpDEFYLAGVVSHGNGCARPQEFGVYTRVTLYL 1375
Cdd:smart00020  151 vsNATCRRaysgGGAITDNMLCAGGLEGGKDACQGDSGGPLVCND----GRWVLVGIVSWGSGCARPGKPGVYTRVSSYL 226


                    ..
gi 47117802    1376 DW 1377
Cdd:smart00020  227 DW 228
DUF1986 pfam09342
Domain of unknown function (DUF1986); This domain is found in serine proteases and is ...
 2041-2158 2.42e-63

Domain of unknown function (DUF1986); This domain is found in serine proteases and is predicted to contain disulphide bonds.


Pssm-ID: 286432  Cd Length: 116  Bit Score: 211.64  E-value: 2.42e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117802   2041 WPWLADVYMNGDLWCIGVLIDKHWVMVHESCLSGIDLETHYVSVLLGGGKTKRSAhRSNHEQIRRVDCFEGVPKSNVLLL 2120
Cdd:pfam09342    1 WPWIAKVYLDGNMICSGVLIDASWVIVSGSCLRDTNLRHQYISVVLGGAKTLKSI-EGPYEQIVRVDCRHDIPESEISLL 79

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 47117802   2121 HLERPVRFTHHVLPTFLPDSSHQNQSHArQCISVLHDD 2158
Cdd:pfam09342   80 HLASPASFSNHVLPTFVPETRNENEKDN-ECLAVGQDD 116
Trypsin pfam00089
Trypsin;
1145-1378 1.31e-52

Trypsin;


Pssm-ID: 459667 [Multi-domain]  Cd Length: 219  Bit Score: 184.95  E-value: 1.31e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117802   1145 IVGGSYTSALQWPFVVAIYRNGKFH-CGGTIYSDRWIISAAHCVinYGKYFYEVRAGLLRRSSYSPATQIQPVSHVVVHQ 1223
Cdd:pfam00089    1 IVGGDEAQPGSFPWQVSLQLSSGKHfCGGSLISENWVLTAAHCV--SGASDVKVVLGAHNIVLREGGEQKFDVEKIIVHP 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117802   1224 AYERRSMRNDLSLLRLLNPLQFNRWVKPICLPDKGRTtvgddwiwgPVEHTLCTVVGWGAIREKGPsSDPMRQVIVPI-- 1301
Cdd:pfam00089   79 NYNPDTLDNDIALLKLESPVTLGDTVRPICLPDASSD---------LPVGTTCTVSGWGNTKTLGP-SDTLQEVTVPVvs 148

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 47117802   1302 RKKCTDPEDQA--SEDICAGdpDGGRDACQGDSGGPLFCRSVsnpdefYLAGVVSHGNGCARPQEFGVYTRVTLYLDWL 1378
Cdd:pfam00089  149 RETCRSAYGGTvtDTMICAG--AGGKDACQGDSGGPLVCSDG------ELIGIVSWGYGCASGNYPGVYTPVSSYLDWI 219
COG5640 COG5640
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, ...
 1144-1379 9.96e-51

Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444365 [Multi-domain]  Cd Length: 262  Bit Score: 181.00  E-value: 9.96e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117802 1144 RIVGGSYTSALQWPFVVAIYRNG---KFHCGGTIYSDRWIISAAHCVINYGKYFYEVRAGLLRRSSySPATQIqPVSHVV 1220
Cdd:COG5640   30 AIVGGTPATVGEYPWMVALQSSNgpsGQFCGGTLIAPRWVLTAAHCVDGDGPSDLRVVIGSTDLST-SGGTVV-KVARIV 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117802 1221 VHQAYERRSMRNDlsllrllnplqfnrW-----------VKPICLPDKGRTTVGDDWIwgpvehtlcTVVGWGAIRE-KG 1288
Cdd:COG5640  108 VHPDYDPATPGND--------------IallklatpvpgVAPAPLATSADAAAPGTPA---------TVAGWGRTSEgPG 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117802 1289 PSSDPMRQVIVPI--RKKCTDPED-QASEDICAGDPDGGRDACQGDSGGPLFcrsVSNPDEFYLAGVVSHGNGCARPQEF 1365
Cdd:COG5640  165 SQSGTLRKADVPVvsDATCAAYGGfDGGTMLCAGYPEGGKDACQGDSGGPLV---VKDGGGWVLVGVVSWGGGPCAAGYP 241

                        250
                 ....*....|....
gi 47117802 1366 GVYTRVTLYLDWLE 1379
Cdd:COG5640  242 GVYTRVSAYRDWIK 255
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2421-2457 1.74e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.91  E-value: 1.74e-09
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 47117802 2421 CTADHFQCSSSpeDCIPRDFVCDKEKDCPNGEDERYC 2457
Cdd:cd00112    1 CPPNEFRCANG--RCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 891-927 2.09e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.82  E-value: 2.09e-08
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 47117802  891 CPePDQFSCfGQQECIPAARWCDNVVDCSDGSDESAC 927
Cdd:cd00112    1 CP-PNEFRC-ANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2421-2454 4.57e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.09  E-value: 4.57e-08
                            10        20        30
                    ....*....|....*....|....*....|....
gi 47117802    2421 CTADHFQCSSSpeDCIPRDFVCDKEKDCPNGEDE 2454
Cdd:smart00192    2 CPPGEFQCDNG--RCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 890-924 1.16e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.94  E-value: 1.16e-07
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 47117802     890 RCPePDQFSCFGQQeCIPAARWCDNVVDCSDGSDE 924
Cdd:smart00192    1 TCP-PGEFQCDNGR-CIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1776-1811 2.23e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.13  E-value: 2.23e-07
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 47117802 1776 CQSNEFRCPlSKTCLPLSSRCDNKVDCKFKEDEKDC 1811
Cdd:cd00112    1 CPPNEFRCA-NGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2421-2457 4.44e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.40  E-value: 4.44e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 47117802   2421 CTADHFQCSSSpeDCIPRDFVCDKEKDCPNGEDERYC 2457
Cdd:pfam00057    3 CSPNEFQCGSG--ECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2350-2383 8.06e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 47.24  E-value: 8.06e-07
                            10        20        30
                    ....*....|....*....|....*....|....
gi 47117802    2350 QCAPGEMKCRTSfKCVPKSKFCDHVPDCEDMTDE 2383
Cdd:smart00192    1 TCPPGEFQCDNG-RCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2309-2339 1.84e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 46.47  E-value: 1.84e-06
                            10        20        30
                    ....*....|....*....|....*....|.
gi 47117802    2309 DCSTHRCPLGTCLPQAAMCNGRSDCHDGSDE 2339
Cdd:smart00192    3 PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2351-2383 3.90e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 45.66  E-value: 3.90e-06
                         10        20        30
                 ....*....|....*....|....*....|...
gi 47117802 2351 CAPGEMKCRtSFKCVPKSKFCDHVPDCEDMTDE 2383
Cdd:cd00112    1 CPPNEFRCA-NGRCIPSSWVCDGEDDCGDGSDE 32
Tryp_SPc smart00020
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ...
 2041-2141 6.04e-06

Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.


Pssm-ID: 214473  Cd Length: 229  Bit Score: 49.98  E-value: 6.04e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117802    2041 WPWLADVYMNGD-LWCIGVLIDKHWVM--VHesCLSGIDLETHYVSVllggGKTKRSahRSNHEQIRRVD------CFEG 2111
Cdd:smart00020   13 FPWQVSLQYGGGrHFCGGSLISPRWVLtaAH--CVRGSDPSNIRVRL----GSHDLS--SGEEGQVIKVSkviihpNYNP 84

                            90       100       110
                    ....*....|....*....|....*....|.
gi 47117802    2112 VPKSN-VLLLHLERPVRFTHHVLPTFLPDSS 2141
Cdd:smart00020   85 STYDNdIALLKLKEPVTLSDNVRPICLPSSN 115
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2311-2340 1.36e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 44.12  E-value: 1.36e-05
                         10        20        30
                 ....*....|....*....|....*....|
gi 47117802 2311 STHRCPLGTCLPQAAMCNGRSDCHDGSDEE 2340
Cdd:cd00112    4 NEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1399-1430 2.28e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 43.35  E-value: 2.28e-05
                         10        20        30
                 ....*....|....*....|....*....|..
gi 47117802 1399 FICVWGgkRCIAKRQRCDRNVDCLGGEDEVGC 1430
Cdd:cd00112    6 FRCANG--RCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1710-1743 2.47e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 43.35  E-value: 2.47e-05
                         10        20        30
                 ....*....|....*....|....*....|....
gi 47117802 1710 PNKFVCKKMSQIvDIMMRCDRKVDCEDGTDELDC 1743
Cdd:cd00112    3 PNEFRCANGRCI-PSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1775-1808 2.47e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 43.01  E-value: 2.47e-05
                            10        20        30
                    ....*....|....*....|....*....|....
gi 47117802    1775 ECQSNEFRCPlSKTCLPLSSRCDNKVDCKFKEDE 1808
Cdd:smart00192    1 TCPPGEFQCD-NGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
889-927 4.46e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 42.62  E-value: 4.46e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 47117802    889 SRCpEPDQFSCfGQQECIPAARWCDNVVDCSDGSDESAC 927
Cdd:pfam00057    1 STC-SPNEFQC-GSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1776-1811 6.35e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 42.24  E-value: 6.35e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 47117802   1776 CQSNEFRCpLSKTCLPLSSRCDNKVDCKFKEDEKDC 1811
Cdd:pfam00057    3 CSPNEFQC-GSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2350-2385 5.05e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 39.54  E-value: 5.05e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 47117802   2350 QCAPGEMKCRTSfKCVPKSKFCDHVPDCEDMTDEPT 2385
Cdd:pfam00057    2 TCSPNEFQCGSG-ECIPRSWVCDGDPDCGDGSDEEN 36
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1710-1740 2.07e-03

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 37.61  E-value: 2.07e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 47117802    1710 PNKFVCKkMSQIVDIMMRCDRKVDCEDGTDE 1740
Cdd:smart00192    4 PGEFQCD-NGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2313-2341 3.47e-03

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 37.23  E-value: 3.47e-03
                           10        20
                   ....*....|....*....|....*....
gi 47117802   2313 HRCPLGTCLPQAAMCNGRSDCHDGSDEEE 2341
Cdd:pfam00057    8 FQCGSGECIPRSWVCDGDPDCGDGSDEEN 36
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1396-1427 3.52e-03

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 37.23  E-value: 3.52e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 47117802    1396 CPG--FICvwGGKRCIAKRQRCDRNVDCLGGEDE 1427
Cdd:smart00192    2 CPPgeFQC--DNGRCIPSSWVCDGVDDCGDGSDE 33
 
Name Accession Description Interval E-value
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 1145-1379 9.59e-74

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 246.03  E-value: 9.59e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117802 1145 IVGGSYTSALQWPFVVAIYRN-GKFHCGGTIYSDRWIISAAHCVINYGKYFYEVRAGLLRRSSYSPATQIQPVSHVVVHQ 1223
Cdd:cd00190    1 IVGGSEAKIGSFPWQVSLQYTgGRHFCGGSLISPRWVLTAAHCVYSSAPSNYTVRLGSHDLSSNEGGGQVIKVKKVIVHP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117802 1224 AYERRSMRNDLSLLRLLNPLQFNRWVKPICLPDKGRTtvgddwiwgPVEHTLCTVVGWGAIREKGPSSDPMRQVIVPI-- 1301
Cdd:cd00190   81 NYNPSTYDNDIALLKLKRPVTLSDNVRPICLPSSGYN---------LPAGTTCTVSGWGRTSEGGPLPDVLQEVNVPIvs 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117802 1302 RKKCTDPEDQASED----ICAGDPDGGRDACQGDSGGPLFCRsvsNPDEFYLAGVVSHGNGCARPQEFGVYTRVTLYLDW 1377
Cdd:cd00190  152 NAECKRAYSYGGTItdnmLCAGGLEGGKDACQGDSGGPLVCN---DNGRGVLVGIVSWGSGCARPNYPGVYTRVSSYLDW 228


                 ..
gi 47117802 1378 LE 1379
Cdd:cd00190  229 IQ 230
Tryp_SPc smart00020
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ...
 1144-1377 1.35e-70

Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.


Pssm-ID: 214473  Cd Length: 229  Bit Score: 236.81  E-value: 1.35e-70
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117802    1144 RIVGGSYTSALQWPFVVAIYRNGKFH-CGGTIYSDRWIISAAHCVINYGKYFYEVRAGLLRRSSYSPATQIQpVSHVVVH 1222
Cdd:smart00020    1 RIVGGSEANIGSFPWQVSLQYGGGRHfCGGSLISPRWVLTAAHCVRGSDPSNIRVRLGSHDLSSGEEGQVIK-VSKVIIH 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117802    1223 QAYERRSMRNDLSLLRLLNPLQFNRWVKPICLPDKGRTtvgddwiwgPVEHTLCTVVGWGAIRE-KGPSSDPMRQVIVPI 1301
Cdd:smart00020   80 PNYNPSTYDNDIALLKLKEPVTLSDNVRPICLPSSNYN---------VPAGTTCTVSGWGRTSEgAGSLPDTLQEVNVPI 150

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117802    1302 --RKKCTD----PEDQASEDICAGDPDGGRDACQGDSGGPLFCRSvsnpDEFYLAGVVSHGNGCARPQEFGVYTRVTLYL 1375
Cdd:smart00020  151 vsNATCRRaysgGGAITDNMLCAGGLEGGKDACQGDSGGPLVCND----GRWVLVGIVSWGSGCARPGKPGVYTRVSSYL 226


                    ..
gi 47117802    1376 DW 1377
Cdd:smart00020  227 DW 228
DUF1986 pfam09342
Domain of unknown function (DUF1986); This domain is found in serine proteases and is ...
 2041-2158 2.42e-63

Domain of unknown function (DUF1986); This domain is found in serine proteases and is predicted to contain disulphide bonds.


Pssm-ID: 286432  Cd Length: 116  Bit Score: 211.64  E-value: 2.42e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117802   2041 WPWLADVYMNGDLWCIGVLIDKHWVMVHESCLSGIDLETHYVSVLLGGGKTKRSAhRSNHEQIRRVDCFEGVPKSNVLLL 2120
Cdd:pfam09342    1 WPWIAKVYLDGNMICSGVLIDASWVIVSGSCLRDTNLRHQYISVVLGGAKTLKSI-EGPYEQIVRVDCRHDIPESEISLL 79

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 47117802   2121 HLERPVRFTHHVLPTFLPDSSHQNQSHArQCISVLHDD 2158
Cdd:pfam09342   80 HLASPASFSNHVLPTFVPETRNENEKDN-ECLAVGQDD 116
Trypsin pfam00089
Trypsin;
1145-1378 1.31e-52

Trypsin;


Pssm-ID: 459667 [Multi-domain]  Cd Length: 219  Bit Score: 184.95  E-value: 1.31e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117802   1145 IVGGSYTSALQWPFVVAIYRNGKFH-CGGTIYSDRWIISAAHCVinYGKYFYEVRAGLLRRSSYSPATQIQPVSHVVVHQ 1223
Cdd:pfam00089    1 IVGGDEAQPGSFPWQVSLQLSSGKHfCGGSLISENWVLTAAHCV--SGASDVKVVLGAHNIVLREGGEQKFDVEKIIVHP 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117802   1224 AYERRSMRNDLSLLRLLNPLQFNRWVKPICLPDKGRTtvgddwiwgPVEHTLCTVVGWGAIREKGPsSDPMRQVIVPI-- 1301
Cdd:pfam00089   79 NYNPDTLDNDIALLKLESPVTLGDTVRPICLPDASSD---------LPVGTTCTVSGWGNTKTLGP-SDTLQEVTVPVvs 148

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 47117802   1302 RKKCTDPEDQA--SEDICAGdpDGGRDACQGDSGGPLFCRSVsnpdefYLAGVVSHGNGCARPQEFGVYTRVTLYLDWL 1378
Cdd:pfam00089  149 RETCRSAYGGTvtDTMICAG--AGGKDACQGDSGGPLVCSDG------ELIGIVSWGYGCASGNYPGVYTPVSSYLDWI 219
COG5640 COG5640
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, ...
 1144-1379 9.96e-51

Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444365 [Multi-domain]  Cd Length: 262  Bit Score: 181.00  E-value: 9.96e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117802 1144 RIVGGSYTSALQWPFVVAIYRNG---KFHCGGTIYSDRWIISAAHCVINYGKYFYEVRAGLLRRSSySPATQIqPVSHVV 1220
Cdd:COG5640   30 AIVGGTPATVGEYPWMVALQSSNgpsGQFCGGTLIAPRWVLTAAHCVDGDGPSDLRVVIGSTDLST-SGGTVV-KVARIV 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117802 1221 VHQAYERRSMRNDlsllrllnplqfnrW-----------VKPICLPDKGRTTVGDDWIwgpvehtlcTVVGWGAIRE-KG 1288
Cdd:COG5640  108 VHPDYDPATPGND--------------IallklatpvpgVAPAPLATSADAAAPGTPA---------TVAGWGRTSEgPG 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117802 1289 PSSDPMRQVIVPI--RKKCTDPED-QASEDICAGDPDGGRDACQGDSGGPLFcrsVSNPDEFYLAGVVSHGNGCARPQEF 1365
Cdd:COG5640  165 SQSGTLRKADVPVvsDATCAAYGGfDGGTMLCAGYPEGGKDACQGDSGGPLV---VKDGGGWVLVGVVSWGGGPCAAGYP 241

                        250
                 ....*....|....
gi 47117802 1366 GVYTRVTLYLDWLE 1379
Cdd:COG5640  242 GVYTRVSAYRDWIK 255
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2421-2457 1.74e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.91  E-value: 1.74e-09
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 47117802 2421 CTADHFQCSSSpeDCIPRDFVCDKEKDCPNGEDERYC 2457
Cdd:cd00112    1 CPPNEFRCANG--RCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 891-927 2.09e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.82  E-value: 2.09e-08
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 47117802  891 CPePDQFSCfGQQECIPAARWCDNVVDCSDGSDESAC 927
Cdd:cd00112    1 CP-PNEFRC-ANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2421-2454 4.57e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.09  E-value: 4.57e-08
                            10        20        30
                    ....*....|....*....|....*....|....
gi 47117802    2421 CTADHFQCSSSpeDCIPRDFVCDKEKDCPNGEDE 2454
Cdd:smart00192    2 CPPGEFQCDNG--RCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 890-924 1.16e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.94  E-value: 1.16e-07
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 47117802     890 RCPePDQFSCFGQQeCIPAARWCDNVVDCSDGSDE 924
Cdd:smart00192    1 TCP-PGEFQCDNGR-CIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1776-1811 2.23e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.13  E-value: 2.23e-07
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 47117802 1776 CQSNEFRCPlSKTCLPLSSRCDNKVDCKFKEDEKDC 1811
Cdd:cd00112    1 CPPNEFRCA-NGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2421-2457 4.44e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.40  E-value: 4.44e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 47117802   2421 CTADHFQCSSSpeDCIPRDFVCDKEKDCPNGEDERYC 2457
Cdd:pfam00057    3 CSPNEFQCGSG--ECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2350-2383 8.06e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 47.24  E-value: 8.06e-07
                            10        20        30
                    ....*....|....*....|....*....|....
gi 47117802    2350 QCAPGEMKCRTSfKCVPKSKFCDHVPDCEDMTDE 2383
Cdd:smart00192    1 TCPPGEFQCDNG-RCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2309-2339 1.84e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 46.47  E-value: 1.84e-06
                            10        20        30
                    ....*....|....*....|....*....|.
gi 47117802    2309 DCSTHRCPLGTCLPQAAMCNGRSDCHDGSDE 2339
Cdd:smart00192    3 PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2351-2383 3.90e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 45.66  E-value: 3.90e-06
                         10        20        30
                 ....*....|....*....|....*....|...
gi 47117802 2351 CAPGEMKCRtSFKCVPKSKFCDHVPDCEDMTDE 2383
Cdd:cd00112    1 CPPNEFRCA-NGRCIPSSWVCDGEDDCGDGSDE 32
Tryp_SPc smart00020
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ...
 2041-2141 6.04e-06

Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.


Pssm-ID: 214473  Cd Length: 229  Bit Score: 49.98  E-value: 6.04e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117802    2041 WPWLADVYMNGD-LWCIGVLIDKHWVM--VHesCLSGIDLETHYVSVllggGKTKRSahRSNHEQIRRVD------CFEG 2111
Cdd:smart00020   13 FPWQVSLQYGGGrHFCGGSLISPRWVLtaAH--CVRGSDPSNIRVRL----GSHDLS--SGEEGQVIKVSkviihpNYNP 84

                            90       100       110
                    ....*....|....*....|....*....|.
gi 47117802    2112 VPKSN-VLLLHLERPVRFTHHVLPTFLPDSS 2141
Cdd:smart00020   85 STYDNdIALLKLKEPVTLSDNVRPICLPSSN 115
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2311-2340 1.36e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 44.12  E-value: 1.36e-05
                         10        20        30
                 ....*....|....*....|....*....|
gi 47117802 2311 STHRCPLGTCLPQAAMCNGRSDCHDGSDEE 2340
Cdd:cd00112    4 NEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1399-1430 2.28e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 43.35  E-value: 2.28e-05
                         10        20        30
                 ....*....|....*....|....*....|..
gi 47117802 1399 FICVWGgkRCIAKRQRCDRNVDCLGGEDEVGC 1430
Cdd:cd00112    6 FRCANG--RCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1710-1743 2.47e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 43.35  E-value: 2.47e-05
                         10        20        30
                 ....*....|....*....|....*....|....
gi 47117802 1710 PNKFVCKKMSQIvDIMMRCDRKVDCEDGTDELDC 1743
Cdd:cd00112    3 PNEFRCANGRCI-PSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1775-1808 2.47e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 43.01  E-value: 2.47e-05
                            10        20        30
                    ....*....|....*....|....*....|....
gi 47117802    1775 ECQSNEFRCPlSKTCLPLSSRCDNKVDCKFKEDE 1808
Cdd:smart00192    1 TCPPGEFQCD-NGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
889-927 4.46e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 42.62  E-value: 4.46e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 47117802    889 SRCpEPDQFSCfGQQECIPAARWCDNVVDCSDGSDESAC 927
Cdd:pfam00057    1 STC-SPNEFQC-GSGECIPRSWVCDGDPDCGDGSDEENC 37
Trypsin pfam00089
Trypsin;
2040-2154 4.82e-05

Trypsin;


Pssm-ID: 459667 [Multi-domain]  Cd Length: 219  Bit Score: 47.05  E-value: 4.82e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47117802   2040 HWPWLADVYMNGD-LWCIGVLIDKHWVMVHESCLSGidleTHYVSVLLGGGKTKRSAHRSNHEQIRRVDCFEGVPKSNVL 2118
Cdd:pfam00089   11 SFPWQVSLQLSSGkHFCGGSLISENWVLTAAHCVSG----ASDVKVVLGAHNIVLREGGEQKFDVEKIIVHPNYNPDTLD 86

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 47117802   2119 ----LLHLERPVRFTHHVLPTFLPDSShqNQSHARQCISV 2154
Cdd:pfam00089   87 ndiaLLKLESPVTLGDTVRPICLPDAS--SDLPVGTTCTV 124
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1776-1811 6.35e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 42.24  E-value: 6.35e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 47117802   1776 CQSNEFRCpLSKTCLPLSSRCDNKVDCKFKEDEKDC 1811
Cdd:pfam00057    3 CSPNEFQC-GSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2350-2385 5.05e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 39.54  E-value: 5.05e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 47117802   2350 QCAPGEMKCRTSfKCVPKSKFCDHVPDCEDMTDEPT 2385
Cdd:pfam00057    2 TCSPNEFQCGSG-ECIPRSWVCDGDPDCGDGSDEEN 36
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1710-1740 2.07e-03

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 37.61  E-value: 2.07e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 47117802    1710 PNKFVCKkMSQIVDIMMRCDRKVDCEDGTDE 1740
Cdd:smart00192    4 PGEFQCD-NGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2313-2341 3.47e-03

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 37.23  E-value: 3.47e-03
                           10        20
                   ....*....|....*....|....*....
gi 47117802   2313 HRCPLGTCLPQAAMCNGRSDCHDGSDEEE 2341
Cdd:pfam00057    8 FQCGSGECIPRSWVCDGDPDCGDGSDEEN 36
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1396-1427 3.52e-03

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 37.23  E-value: 3.52e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 47117802    1396 CPG--FICvwGGKRCIAKRQRCDRNVDCLGGEDE 1427
Cdd:smart00192    2 CPPgeFQC--DNGRCIPSSWVCDGVDDCGDGSDE 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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